pharma processing mpt sls - scalable lab … all...all product 2016 with quadro® products, you can...
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All Product 2016
With Quadro® products, you can rely on superior engineering and manufacturing quality for maximum uptime and yield. Our products are backed by the highest level of application and technical support, based on more than 40 years of experience.
613 Colby Drive Waterloo, ON, CA N2V [email protected]
SCALABLE LAB SYSTEM (SLS)
• Ability to alternate between five milling solutions in seconds• Utilizes Smart-Detect, a unique lab equipment feature that automatically
ensures the appropriate scalable speed range is fixed by recognizing the head being installed
• PSD and capacity scalable with simple operating parameters transfer from small sample R&D tests, to full-scale production machines
• Suitable for dry milling and/or wet material conditioning, as stand-alone or to complement lab-scale wet granulation systems
• Process samples as small as 5 grams with minimal loss or product retention, or as large as +100 kg/hr for certain products & models
• 95%+ product recovery
QUADRO® – world’s leader in uniform size reduction, sieving and deagglomeration
• Knowledge and problem-solving experience gained through more than 20,000 applications
• Optimized designs for maximized return-on-investment• Engineered and customized equipment to improve
process requirements• Serving primarily the Pharmaceutical and Food
industries• Continuous innovation ensures market has best
and most competitive solutions
Quadro Engineering Headquarters, Waterloo, Ontario, Canada
QUADRO® COMIL® U5 AND U5 HIGH-EFFICIENCY
• In-line, spacerless design• Tight particle granulometry• Wide range of scalable screens/impellers• Low heat, fines, dust and overs
FITZMILL L1A
• Same process advantages of larger scale FitzMill comminutors – fully scalable
• Available metered feed system (VFS) for complete process repeatability
QUADRO® FLEXSIFT S5
• In-line security screener• High capacity (typical 500 kg/hr)• Standard deagglomeration spoiler arm
QUADRO® H5 HIGH ENERGY COMIL®
• Primarily APIs, fine chemical and cosmetic applications• Narrow PSDs with 30-70% more on-target• Integrated feed system for optimized containment
and predictability
SPECIFICATIONS COMIL® U5
CAPACITIES 50 g to 150+ kg/hr
RPM up to 6500
MOTOR ¾ HP (0.5kW)
PSDsd50 150-300 µm
d90 300-2000+ µm
SPECIFICATIONS FITZMILL L1A
CAPACITIES 5 g to 50+ kg/hr
RPM up to 15000
MOTOR ¾ HP (0.5kW)
PSDsd50 20-300 µm
d90 60-2000 µm
SPECIFICATIONS FLEXSIFT S5
CAPACITIES <125-2500+ kg/hr
RPM up to 3500
MOTOR ¾ HP (0.5kW)
MESH SIZEmin 150 µm (100 mesh)
max 6.4 mm (0.25")
SPECIFICATIONS COMIL® H5
CAPACITIES <1 kg to 100 kg/hr
RPM up to 12800
MOTOR ¾ HP (0.5kW)
PSDsd50 20-150 µm
d90 60-300 µm
Waterloo, ON, Canada
Westwood, MA, USA
Evesham, UK
Shanghai, China
Elmhurst, IL, USA
World Headquarters
Division Headquarters
Centers of Excellence
MPT GLOBAL LOCATIONS:
MPT PHARMA PROCESSING
Leading Process Equipment Innovation
MPT PHARMA PROCESSING
Who We AreMPT PHARMA PROCESSING
SLS - Scalable Lab System
Dry/Wet Oral Solid Dosage Material Processing
APIs, Fine Chemical, Cosmetic Fine Grinding
SLS - Scalable Lab System
Food, Industrial Material Processing
On-site Training
Bundled Packages
Customizations Engineered
Systems
Proof of Concept
Spare Parts Kits
In-house Seminars
Process Development Optimization
CUSTOMER
BEFORE
AFTER
Model G98 with optional casters
Quadro® Flexsift Model GS20
FLEXSIFT SECURITY SCREENING
• High capacity security screening
• Ideal for in-line installations – bulk bag unloading or vacuum conveying
• Available deagglomeration option
• OEB 5 (<1 µg/m3) containment
QUADRO® H20 HIGH ENERGY COMIL®
• Ideal for APIs, fine chemicals and cosmetics
• Narrow PSDs with 30-70% more on-target
• Optimum performance and containment when integrated with feed system
• OEB 5 (<1 µg/m3) containment
• No need for air handling systems
• Easy parameter controls for added PSD consistency
OVERDRIVEN G SERIES LINE
• 50% more throughput than conventional mills due to bulk feeding capability
• Well-suited for heat-sensitive products
• Ideal for high volume, bulk density fine-tuning and deagglomeration
• Reduced cost of ownership
UNDERDRIVEN COMIL® SERIES
• Compact in-line high capacity
• OEB 5 (<1 µg/m3) containment
• Narrow PSDs (wide range of screens/impellers and RPM control)
• Ideal for heat-sensitive products
• WIP/CIP/SIP capable
F10 FINE GRIND
• APIs and fine chemicals
• Product recovery of +99%
• Narrow API PSDs (very tight spans)
• Unmatched particle size controllability
• Product collector filter efficiency of 99.997% over 50 hr period
• OEB 5 (<1 µg/m3) containment
COSMETICS • Optimized pigment dispersion• More effective blush finish with
less color ingredient
FLEXSIFT SECURITY SCREENING
UNDERDRIVEN G SERIES LINE
• Compact, in-line, high capacity
• Tri-clamp design eliminates dust generation
• Minimal contact surface area for cleaning in minutes
• Often best-suited for bulk-feeding
OVERDRIVEN COMIL® SERIES
• Original platform offers wide capacity range
• Ideal for hand feeding and delumping applications
• Reduced cost of ownership
• Widest range of tooling
UNDERDRIVEN AVAILABLE OPTIONS:
• Isolator integration
• Autoclaves
• WIP/CIP/SIP
• Through-the-wall
• Inert applications
• Wet granulation integrated
• Vacuum conveying adaptors
• ATEX/XP
AVAILABLE DESIGNS:AVAILABLE OPTIONS:
• Isolator integration
• Vacuum conveying adaptors
• WIP (H20 also SIP)
• Inert applications
• ATEX/XP
• In-line analysis ready
COMMON APPLICATIONS:
Heat-sensitive, sticky and difficult materials can be size reduced continuously at a high capacity without excessive heat build-up or screen blockage. The Comil® can:
• Produce free-flowing particles, chunky paste, fine paste or syrup
• Disperse fat homogeneously in baking and flavor mixes to reduce finishing time (doughnuts, pancakes, muffins, cakes, flavor ingredients and soup mixes)
• Size reduce for reclaim of snack foods (candies, cream-filled wafers, chocolate bars, cookies, granola bars, chewing gum)
• Deagglomerate/delump sticky, hot cooked cereal to uniform pieces prior to flaker and dryer, and powders such as sugar, starch, flour, gelatin and cocoa
• Deagglomerate spray-dried products such as cheese or milk products, dairy and non-dairy creamers
• Fine-tune bulk density of various powders
SPECIFICATIONS UNDERDRIVEN COMIL®
MODEL U5 U10 U20 U30
SCALE-UP FACTOR 1 2 10 20
Wet 375Q (9.5 mm) kg/hr Lab-Scale 450 2250 4500
Dry 094R (2.4 mm) kg/hr 200 400 2000 4000
Dry 040G (1.0 mm) kg/hr 50 100 500 1000
MOTOR 0.5 HP (.375kW)
2 HP (1.5kW)
5 HP (4kW)
10 HP (7.5kW)
COMIL® H20 PSDs
INITIAL POST H20
PRODUCT d90 d10 d50 d90
API "A" 258 6 23 91
API "B" 201 9 43 122
API "C" 135 12 32 74
API "D" 285 1.5 33 97
API "E" 76 7 21 57
F10 FINE GRIND PSDs
PRODUCT d10 d50 d90 Kg/hr
API "A" 2 12 49 170
API "B" 2 10 33 90
API "C" 1 7 20 43
API "D" 3 19 63 108
API "E" 6 22 68 50
Budesonide 1 5 11 40
Creatine 1 6 21 10
SPECIFICATIONS COMIL® H20
CAPACITIES 100-500 kg/hr
RPM 3000-7200
MOTOR 7.5 HP (5kW)
PSDsd50 20-150 µm
d90 60-300 µm
SPECIFICATIONS F10 FINE GRIND
CAPACITIES 10-200 kg/hr
RPM 3600-8400
MOTOR 10 HP (7.5kW)
PSDsd50 5-45 µm
d90 11-60 µm
SPECIFICATIONS OVERDRIVEN G SERIES
MODEL G96 G98FOOD/INDUSTRIAL 125R (3 mm)
kg/hr 15400 27000
MOTOR 10 HP (7.5kW)
20 HP (15kW)
SPECIFICATIONS UNDERDRIVEN G SERIES
MODEL G20 G30 GS20FOOD/INDUSTRIAL 125R (3 mm)
kg/hr 6800 13600 17500
MOTOR 5 HP (4kW)
10 HP (7.5kW)
5 HP (4kW)
S20 CAPACITIES/APPLICATIONS
PRODUCT SCREEN DIAMETER Kg/hr
Acetaminophen 0.039" (1.0 mm) 3550
Lactose 0.045" (1.1 mm) 17500
API 0.009" (200 µm) 750
Glucosamine 0.075" (1.9 mm) 1600
MODEL S5 S10 S20
SCALE-UP FACTOR 1 2 4
SPECIFICATIONS OVERDRIVEN COMIL®
MODEL 197 194 196 198
SCALE-UP FACTOR 1 5 10 20
Wet 375Q (9.5 mm) kg/hr 220 1100 2200 N/A
Dry 094R (2.4 mm) kg/hr 360 1750 3500 7000
Dry 040G (1.0 mm) kg/hr 80 400 800 1600
MOTOR 2 HP (1.5kW)
5 HP (4kW)
10 HP (7.5kW)
20 HP (15kW)
• High capacity security screening• Ideal for in-line installations – bulk bag unloading
or vacuum conveying• Deagglomeration option available
Model U21 shown
S20 in-line purged, weighing system
U20 wet granulation integration
U5 integrated with flexible isolator
S20 in-line dispensing
F10 ATEX-rated with inertion
Before milling Mean : 353.22 µm
After F10 milling Mean : 19.35 µm
H20 with dosing valve F10 with WIP option
High Efficiency Model U21 with up to 40% more capacity than U20.
UNDERDRIVEN AVAILABLE DESIGNS:
Draw-down test
MPT PHARMA PROCESSING
Dry/Wet Oral Solid Dosage Processing
MPT PHARMA PROCESSING
APIs, Fine Chemical & Cosmetic Fine Grinding
MPT PHARMA PROCESSING
Food, Industrial Material Processing
U20 through-the-wall