pharma processing mpt sls - scalable lab … all...all product 2016 with quadro® products, you can...

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All Product 2016 With Quadro® products, you can rely on superior engineering and manufacturing quality for maximum uptime and yield. Our products are backed by the highest level of application and technical support, based on more than 40 years of experience. 613 Colby Drive Waterloo, ON, CA N2V 1A1 [email protected] www.quadro.com SCALABLE LAB SYSTEM (SLS) Ability to alternate between five milling solutions in seconds Utilizes Smart-Detect, a unique lab equipment feature that automatically ensures the appropriate scalable speed range is fixed by recognizing the head being installed PSD and capacity scalable with simple operating parameters transfer from small sample R&D tests, to full-scale production machines Suitable for dry milling and/or wet material conditioning, as stand-alone or to complement lab-scale wet granulation systems Process samples as small as 5 grams with minimal loss or product retention, or as large as +100 kg/hr for certain products & models 95%+ product recovery QUADRO ® – world’s leader in uniform size reduction, sieving and deagglomeration Knowledge and problem-solving experience gained through more than 20,000 applications Optimized designs for maximized return-on-investment Engineered and customized equipment to improve process requirements Serving primarily the Pharmaceutical and Food industries Continuous innovation ensures market has best and most competitive solutions Quadro Engineering Headquarters, Waterloo, Ontario, Canada QUADRO ® COMIL ® U5 AND U5 HIGH-EFFICIENCY In-line, spacerless design Tight particle granulometry Wide range of scalable screens/impellers Low heat, fines, dust and overs FITZMILL L1A Same process advantages of larger scale FitzMill comminutors – fully scalable Available metered feed system (VFS) for complete process repeatability QUADRO ® FLEXSIFT S5 In-line security screener High capacity (typical 500 kg/hr) Standard deagglomeration spoiler arm QUADRO ® H 5 HIGH ENERGY COMIL ® Primarily APIs, fine chemical and cosmetic applications Narrow PSDs with 30-70% more on-target Integrated feed system for optimized containment and predictability SPECIFICATIONS COMIL ® U5 CAPACITIES 50 g to 150+ kg/hr RPM up to 6500 MOTOR ¾ HP (0.5kW) PSDs d50 150-300 µm d90 300-2000+ µm SPECIFICATIONS FITZMILL L1A CAPACITIES 5 g to 50+ kg/hr RPM up to 15000 MOTOR ¾ HP (0.5kW) PSDs d50 20-300 µm d90 60-2000 µm SPECIFICATIONS FLEXSIFT S5 CAPACITIES <125-2500+ kg/hr RPM up to 3500 MOTOR ¾ HP (0.5kW) MESH SIZE min 150 µm (100 mesh) max 6.4 mm (0.25") SPECIFICATIONS COMIL ® H 5 CAPACITIES <1 kg to 100 kg/hr RPM up to 12800 MOTOR ¾ HP (0.5kW) PSDs d50 20-150 µm d90 60-300 µm Waterloo, ON, Canada Westwood, MA, USA Evesham, UK Shanghai, China Elmhurst, IL, USA World Headquarters Division Headquarters Centers of Excellence MPT GLOBAL LOCATIONS: MPT PHARMA PROCESSING Leading Process Equipment Innovation MPT PHARMA PROCESSING Who We Are MPT PHARMA PROCESSING SLS - Scalable Lab System Dry/Wet Oral Solid Dosage Material Processing APIs, Fine Chemical, Cosmetic Fine Grinding SLS - Scalable Lab System Food, Industrial Material Processing On-site Training Bundled Packages Customizations Engineered Systems Proof of Concept Spare Parts Kits In-house Seminars Process Development Optimization CUSTOMER

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Page 1: PHARMA PROCESSING MPT SLS - Scalable Lab … All...All Product 2016 With Quadro® products, you can rely on superior engineering and manufacturing quality for maximum uptime and yield

All Product 2016

With Quadro® products, you can rely on superior engineering and manufacturing quality for maximum uptime and yield. Our products are backed by the highest level of application and technical support, based on more than 40 years of experience.

613 Colby Drive Waterloo, ON, CA N2V [email protected]

SCALABLE LAB SYSTEM (SLS)

• Ability to alternate between five milling solutions in seconds• Utilizes Smart-Detect, a unique lab equipment feature that automatically

ensures the appropriate scalable speed range is fixed by recognizing the head being installed

• PSD and capacity scalable with simple operating parameters transfer from small sample R&D tests, to full-scale production machines

• Suitable for dry milling and/or wet material conditioning, as stand-alone or to complement lab-scale wet granulation systems

• Process samples as small as 5 grams with minimal loss or product retention, or as large as +100 kg/hr for certain products & models

• 95%+ product recovery

QUADRO® – world’s leader in uniform size reduction, sieving and deagglomeration

• Knowledge and problem-solving experience gained through more than 20,000 applications

• Optimized designs for maximized return-on-investment• Engineered and customized equipment to improve

process requirements• Serving primarily the Pharmaceutical and Food

industries• Continuous innovation ensures market has best

and most competitive solutions

Quadro Engineering Headquarters, Waterloo, Ontario, Canada

QUADRO® COMIL® U5 AND U5 HIGH-EFFICIENCY

• In-line, spacerless design• Tight particle granulometry• Wide range of scalable screens/impellers• Low heat, fines, dust and overs

FITZMILL L1A

• Same process advantages of larger scale FitzMill comminutors – fully scalable

• Available metered feed system (VFS) for complete process repeatability

QUADRO® FLEXSIFT S5

• In-line security screener• High capacity (typical 500 kg/hr)• Standard deagglomeration spoiler arm

QUADRO® H5 HIGH ENERGY COMIL®

• Primarily APIs, fine chemical and cosmetic applications• Narrow PSDs with 30-70% more on-target• Integrated feed system for optimized containment

and predictability

SPECIFICATIONS COMIL® U5

CAPACITIES 50 g to 150+ kg/hr

RPM up to 6500

MOTOR ¾ HP (0.5kW)

PSDsd50 150-300 µm

d90 300-2000+ µm

SPECIFICATIONS FITZMILL L1A

CAPACITIES 5 g to 50+ kg/hr

RPM up to 15000

MOTOR ¾ HP (0.5kW)

PSDsd50 20-300 µm

d90 60-2000 µm

SPECIFICATIONS FLEXSIFT S5

CAPACITIES <125-2500+ kg/hr

RPM up to 3500

MOTOR ¾ HP (0.5kW)

MESH SIZEmin 150 µm (100 mesh)

max 6.4 mm (0.25")

SPECIFICATIONS COMIL® H5

CAPACITIES <1 kg to 100 kg/hr

RPM up to 12800

MOTOR ¾ HP (0.5kW)

PSDsd50 20-150 µm

d90 60-300 µm

Waterloo, ON, Canada

Westwood, MA, USA

Evesham, UK

Shanghai, China

Elmhurst, IL, USA

World Headquarters

Division Headquarters

Centers of Excellence

MPT GLOBAL LOCATIONS:

MPT PHARMA PROCESSING

Leading Process Equipment Innovation

MPT PHARMA PROCESSING

Who We AreMPT PHARMA PROCESSING

SLS - Scalable Lab System

Dry/Wet Oral Solid Dosage Material Processing

APIs, Fine Chemical, Cosmetic Fine Grinding

SLS - Scalable Lab System

Food, Industrial Material Processing

On-site Training

Bundled Packages

Customizations Engineered

Systems

Proof of Concept

Spare Parts Kits

In-house Seminars

Process Development Optimization

CUSTOMER

Page 2: PHARMA PROCESSING MPT SLS - Scalable Lab … All...All Product 2016 With Quadro® products, you can rely on superior engineering and manufacturing quality for maximum uptime and yield

BEFORE

AFTER

Model G98 with optional casters

Quadro® Flexsift Model GS20

FLEXSIFT SECURITY SCREENING

• High capacity security screening

• Ideal for in-line installations – bulk bag unloading or vacuum conveying

• Available deagglomeration option

• OEB 5 (<1 µg/m3) containment

QUADRO® H20 HIGH ENERGY COMIL®

• Ideal for APIs, fine chemicals and cosmetics

• Narrow PSDs with 30-70% more on-target

• Optimum performance and containment when integrated with feed system

• OEB 5 (<1 µg/m3) containment

• No need for air handling systems

• Easy parameter controls for added PSD consistency

OVERDRIVEN G SERIES LINE

• 50% more throughput than conventional mills due to bulk feeding capability

• Well-suited for heat-sensitive products

• Ideal for high volume, bulk density fine-tuning and deagglomeration

• Reduced cost of ownership

UNDERDRIVEN COMIL® SERIES

• Compact in-line high capacity

• OEB 5 (<1 µg/m3) containment

• Narrow PSDs (wide range of screens/impellers and RPM control)

• Ideal for heat-sensitive products

• WIP/CIP/SIP capable

F10 FINE GRIND

• APIs and fine chemicals

• Product recovery of +99%

• Narrow API PSDs (very tight spans)

• Unmatched particle size controllability

• Product collector filter efficiency of 99.997% over 50 hr period

• OEB 5 (<1 µg/m3) containment

COSMETICS • Optimized pigment dispersion• More effective blush finish with

less color ingredient

FLEXSIFT SECURITY SCREENING

UNDERDRIVEN G SERIES LINE

• Compact, in-line, high capacity

• Tri-clamp design eliminates dust generation

• Minimal contact surface area for cleaning in minutes

• Often best-suited for bulk-feeding

OVERDRIVEN COMIL® SERIES

• Original platform offers wide capacity range

• Ideal for hand feeding and delumping applications

• Reduced cost of ownership

• Widest range of tooling

UNDERDRIVEN AVAILABLE OPTIONS:

• Isolator integration

• Autoclaves

• WIP/CIP/SIP

• Through-the-wall

• Inert applications

• Wet granulation integrated

• Vacuum conveying adaptors

• ATEX/XP

AVAILABLE DESIGNS:AVAILABLE OPTIONS:

• Isolator integration

• Vacuum conveying adaptors

• WIP (H20 also SIP)

• Inert applications

• ATEX/XP

• In-line analysis ready

COMMON APPLICATIONS:

Heat-sensitive, sticky and difficult materials can be size reduced continuously at a high capacity without excessive heat build-up or screen blockage. The Comil® can:

• Produce free-flowing particles, chunky paste, fine paste or syrup

• Disperse fat homogeneously in baking and flavor mixes to reduce finishing time (doughnuts, pancakes, muffins, cakes, flavor ingredients and soup mixes)

• Size reduce for reclaim of snack foods (candies, cream-filled wafers, chocolate bars, cookies, granola bars, chewing gum)

• Deagglomerate/delump sticky, hot cooked cereal to uniform pieces prior to flaker and dryer, and powders such as sugar, starch, flour, gelatin and cocoa

• Deagglomerate spray-dried products such as cheese or milk products, dairy and non-dairy creamers

• Fine-tune bulk density of various powders

SPECIFICATIONS UNDERDRIVEN COMIL®

MODEL U5 U10 U20 U30

SCALE-UP FACTOR 1 2 10 20

Wet 375Q (9.5 mm) kg/hr Lab-Scale 450 2250 4500

Dry 094R (2.4 mm) kg/hr 200 400 2000 4000

Dry 040G (1.0 mm) kg/hr 50 100 500 1000

MOTOR 0.5 HP (.375kW)

2 HP (1.5kW)

5 HP (4kW)

10 HP (7.5kW)

COMIL® H20 PSDs

INITIAL POST H20

PRODUCT d90 d10 d50 d90

API "A" 258 6 23 91

API "B" 201 9 43 122

API "C" 135 12 32 74

API "D" 285 1.5 33 97

API "E" 76 7 21 57

F10 FINE GRIND PSDs

PRODUCT d10 d50 d90 Kg/hr

API "A" 2 12 49 170

API "B" 2 10 33 90

API "C" 1 7 20 43

API "D" 3 19 63 108

API "E" 6 22 68 50

Budesonide 1 5 11 40

Creatine 1 6 21 10

SPECIFICATIONS COMIL® H20

CAPACITIES 100-500 kg/hr

RPM 3000-7200

MOTOR 7.5 HP (5kW)

PSDsd50 20-150 µm

d90 60-300 µm

SPECIFICATIONS F10 FINE GRIND

CAPACITIES 10-200 kg/hr

RPM 3600-8400

MOTOR 10 HP (7.5kW)

PSDsd50 5-45 µm

d90 11-60 µm

SPECIFICATIONS OVERDRIVEN G SERIES

MODEL G96 G98FOOD/INDUSTRIAL 125R (3 mm)

kg/hr 15400 27000

MOTOR 10 HP (7.5kW)

20 HP (15kW)

SPECIFICATIONS UNDERDRIVEN G SERIES

MODEL G20 G30 GS20FOOD/INDUSTRIAL 125R (3 mm)

kg/hr 6800 13600 17500

MOTOR 5 HP (4kW)

10 HP (7.5kW)

5 HP (4kW)

S20 CAPACITIES/APPLICATIONS

PRODUCT SCREEN DIAMETER Kg/hr

Acetaminophen 0.039" (1.0 mm) 3550

Lactose 0.045" (1.1 mm) 17500

API 0.009" (200 µm) 750

Glucosamine 0.075" (1.9 mm) 1600

MODEL S5 S10 S20

SCALE-UP FACTOR 1 2 4

SPECIFICATIONS OVERDRIVEN COMIL®

MODEL 197 194 196 198

SCALE-UP FACTOR 1 5 10 20

Wet 375Q (9.5 mm) kg/hr 220 1100 2200 N/A

Dry 094R (2.4 mm) kg/hr 360 1750 3500 7000

Dry 040G (1.0 mm) kg/hr 80 400 800 1600

MOTOR 2 HP (1.5kW)

5 HP (4kW)

10 HP (7.5kW)

20 HP (15kW)

• High capacity security screening• Ideal for in-line installations – bulk bag unloading

or vacuum conveying• Deagglomeration option available

Model U21 shown

S20 in-line purged, weighing system

U20 wet granulation integration

U5 integrated with flexible isolator

S20 in-line dispensing

F10 ATEX-rated with inertion

Before milling Mean : 353.22 µm

After F10 milling Mean : 19.35 µm

H20 with dosing valve F10 with WIP option

High Efficiency Model U21 with up to 40% more capacity than U20.

UNDERDRIVEN AVAILABLE DESIGNS:

Draw-down test

MPT PHARMA PROCESSING

Dry/Wet Oral Solid Dosage Processing

MPT PHARMA PROCESSING

APIs, Fine Chemical & Cosmetic Fine Grinding

MPT PHARMA PROCESSING

Food, Industrial Material Processing

U20 through-the-wall