pgs infographic copy

1
3 4 1 2 A small sample of cells are removed from the outside layer of a blastocyst embryo. The cells that have been removed from each embryo are loaded into a small tube and sent to the reference laboratory for Next Generation Sequenc- The cells are analyzed to verify that all 23 sets of chromosome pairs are identified to confirm the embryo is genetically normal. Based on the genetic results, you and your medical team will select which embryo will be transferred. How PGS/NGS Works % NORMAL EMBRYO BY AGE GROUP AGE <35 years 35-37 years 38-40 years 41-42 years > 42 years Egg Donors % Normal Blastocyst 48% 44% 33% 17% 11% 61% 2 Weeks Monitoring Day 3 Menstrual Cycle Begin Monitoring ER Retrieval Insemination Day Fertilization Day 2 2-4 Cells Day 3 6-8 Cells Biopsy Preparation Begins (Assisted Hatching) Biopsy Process & Blastocyst Freezing Occurs D0 D1 D2 D3 D4 D5 D6 D7 Confirmation of sending biopsy samples out for testing Completion of IVF Cycle 7-10 days PGS Test Results Next Cycle Day 3 Frozen Embryo Transfer (FET) Cycle preparation IVF TIMELINE FOR PGS/NGS <35 35-37 38-40 41-42 >42 MATERNAL AGE PREGNANCY RATES WITHOUT PGS* WITH PGS* 66% 68% 69% 76% 66% 4.5% 10.2% 19% 30% 39.5% PGD (Preimplantation Genetic Diagnosis) diagnoses embryos for known genetic disorders that both the patient and partner are carriers of including: Sickle cell, Cystic Fibrosis, SMA1, Tay Sachs, Fragile X, etc. PGS (Preimplantation Genetic Screening) screens embryos to ensure 23 pairs of chromosomes (22 autosomes and the sex chromosomes X and Y) are present and there is no aneuploidy. PGS VS PGD Next Generation Sequencing or NGS is a form of preimplantation genetic screening that can be performed on embryos. -Ensures 23 pairs of genetic chromosomes are present -Ensure no aneuploidy* is occurring -Detect mosaicism (fragmented chromosomes) *ANEUPLOIDY IS THE MAIN CAUSE OF FAILED IMPLANTATION AND RECURRING PREGNANCY LOSS. WHAT IS NGS? Reduce chance of miscarriage Reduce # of IVF cycles Reduce risk of multiple pregnancy Increased live birth rates Increased ongoing pregancy rates NGSBENEFITS GENETIC SCREENING 101 For more informaon please contact us: Email: [email protected] Phone: (212) 969-7430 4 Columbus Circle Floor 4 New York City, NY 10012 www.newhopeferlity.com *Provided stascs reflect naonal averages and not guaranteed clinic results

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Page 1: PGS INfographic copy

3

4

1

2

A small sample of cells are removed from the outside layer of a blastocyst embryo.

The cells that have been removed from each embryo are loaded into a small tube and sent to the reference laboratory for Next Generation Sequenc-

The cells are analyzed to verify that all 23 sets of chromosome pairs are identified to confirm the embryo is genetically normal.

Based on the genetic results, you and your medical team will select which embryo will be transferred.

How

PG

S/N

GS

Wor

ks

% NORMAL EMBRYOBY AGE GROUP

AGE

<35 years

35-37 years

38-40 years

41-42 years

> 42 years

Egg Donors

% Normal Blastocyst

48%

44%

33%

17%

11%

61%

2 Weeks Monitoring

Day 3Menstrual CycleBegin Monitoring

ER RetrievalInsemination

Day

Fertilization Day 22-4 Cells

Day 36-8 CellsBiopsy

Preparation Begins(Assisted Hatching)

Biopsy Process & Blastocyst

Freezing Occurs

D0 D1 D2 D3 D4 D5 D6 D7

Confirmation of sending biopsy samples out for

testing

Completion of IVF Cycle 7-10 days

PGS Test Results

Next Cycle Day 3

Frozen Embryo Transfer (FET)

Cycle preparation

IVF TIMELINE FOR PGS/NGS

<35 35-37 38-40 41-42 >42

MATERNAL AGE

PREG

NA

NC

Y R

ATE

S

WITHOUTPGS*

WITH PGS*

66%68% 69%

76%

66%

4.5%

10.2%

19%

30%

39.5%

PGD (Preimplantation Genetic Diagnosis) diagnoses embryos for known genetic disorders that

both the patient and partner are carriers of including: Sickle cell,

Cystic Fibrosis, SMA1, Tay Sachs, Fragile X, etc.

PGS (Preimplantation Genetic Screening) screens embryos to

ensure 23 pairs of chromosomes (22 autosomes and the sex chromosomes X and Y) are

present and there is no aneuploidy.

PGSVS

PGDNext Generation Sequencing or NGS

is a form of preimplantation genetic screening that can be performed on embryos. -Ensures 23 pairs of genetic chromosomes are present

-Ensure no aneuploidy* is occurring-Detect mosaicism (fragmented

chromosomes)

*ANEUPLOIDY IS THE MAIN CAUSE OF FAILED IMPLANTATION AND RECURRING PREGNANCY LOSS.

WHAT IS NGS?

Reduce chance of miscarriageReduce # of IVF cycles

Reduce risk of multiple pregnancyIncreased live birth rates

Increased ongoing pregancy rates

NGSBENEFITS

GENETIC SCREENING 101

For more information please contact us:Email: [email protected]: (212) 969-7430

4 Columbus CircleFloor 4

New York City, NY 10012www.newhopefertility.com

*Pro

vide

d st

atisti

cs re

flect

nati

onal

ave

rage

s an

d no

t gu

aran

teed

clin

ic re

sults