pet imaging of glutaminolysis in tumors by 18 f-(2s,4r)4-fluoroglutamine
DESCRIPTION
PET Imaging of Glutaminolysis in Tumors by 18 F-(2S,4R)4-Fluoroglutamine. Reporter: Fei Liu Supervisor: Prof. Zhi Yang 31 March 2014 Mentor: Nan Li and Hua Zhu. Kung HF, et al, J Nucl Med, 2011, 52(12):1947-55. PET Imaging of Glutaminolysis in Tumors by 18F-(2S,4R)4-Fluoroglutamine. - PowerPoint PPT PresentationTRANSCRIPT
![Page 1: PET Imaging of Glutaminolysis in Tumors by 18 F-(2S,4R)4-Fluoroglutamine](https://reader036.vdocuments.us/reader036/viewer/2022062409/568150af550346895dbecac0/html5/thumbnails/1.jpg)
PET Imaging of Glutaminolysis in Tumors by18F-(2S,4R)4-Fluoroglutamine
Reporter: Fei Liu
Supervisor: Prof. Zhi Yang
31 March 2014
Mentor: Nan Li and Hua Zhu
Kung HF, et al, J Nucl Med, 2011, 52(12):1947-55.
![Page 2: PET Imaging of Glutaminolysis in Tumors by 18 F-(2S,4R)4-Fluoroglutamine](https://reader036.vdocuments.us/reader036/viewer/2022062409/568150af550346895dbecac0/html5/thumbnails/2.jpg)
Contents:
PET Imaging of Glutaminolysis in Tumors by18F-(2S,4R)4-Fluoroglutamine
Reporter: Fei Liu
Supervisor: Prof. Zhi Yang
31 March 2014
Mentor: Nan Li and Hua Zhu
![Page 3: PET Imaging of Glutaminolysis in Tumors by 18 F-(2S,4R)4-Fluoroglutamine](https://reader036.vdocuments.us/reader036/viewer/2022062409/568150af550346895dbecac0/html5/thumbnails/3.jpg)
Contents:PET Imaging of Glutaminolysis in Tumors by
18F-(2S,4R)4-Fluoroglutamine
Reporter: Fei Liu
Supervisor: Prof. Zhi Yang
31 March 2014
Mentor: Nan Li and Hua Zhu
Contents:
Conten
ts:
![Page 4: PET Imaging of Glutaminolysis in Tumors by 18 F-(2S,4R)4-Fluoroglutamine](https://reader036.vdocuments.us/reader036/viewer/2022062409/568150af550346895dbecac0/html5/thumbnails/4.jpg)
Conten
ts:
1 Background 2 Research3 Summary 4Development
![Page 5: PET Imaging of Glutaminolysis in Tumors by 18 F-(2S,4R)4-Fluoroglutamine](https://reader036.vdocuments.us/reader036/viewer/2022062409/568150af550346895dbecac0/html5/thumbnails/5.jpg)
Conten
ts:
1 Background 2 Research3 Summary 4Development
![Page 6: PET Imaging of Glutaminolysis in Tumors by 18 F-(2S,4R)4-Fluoroglutamine](https://reader036.vdocuments.us/reader036/viewer/2022062409/568150af550346895dbecac0/html5/thumbnails/6.jpg)
1Background
![Page 7: PET Imaging of Glutaminolysis in Tumors by 18 F-(2S,4R)4-Fluoroglutamine](https://reader036.vdocuments.us/reader036/viewer/2022062409/568150af550346895dbecac0/html5/thumbnails/7.jpg)
Conten
ts:
1 Background 2 Research3 Summary 4Development
![Page 8: PET Imaging of Glutaminolysis in Tumors by 18 F-(2S,4R)4-Fluoroglutamine](https://reader036.vdocuments.us/reader036/viewer/2022062409/568150af550346895dbecac0/html5/thumbnails/8.jpg)
2Research
Kung HF, et al, J Nucl Med, 2011, 52(12):1947-55.
![Page 9: PET Imaging of Glutaminolysis in Tumors by 18 F-(2S,4R)4-Fluoroglutamine](https://reader036.vdocuments.us/reader036/viewer/2022062409/568150af550346895dbecac0/html5/thumbnails/9.jpg)
2Research
Kung HF, et al, J Nucl Med, 2011, 52(12):1947-55.
![Page 10: PET Imaging of Glutaminolysis in Tumors by 18 F-(2S,4R)4-Fluoroglutamine](https://reader036.vdocuments.us/reader036/viewer/2022062409/568150af550346895dbecac0/html5/thumbnails/10.jpg)
2Research
Kung HF, et al, J Nucl Med, 2011, 52(12):1947-55.
![Page 11: PET Imaging of Glutaminolysis in Tumors by 18 F-(2S,4R)4-Fluoroglutamine](https://reader036.vdocuments.us/reader036/viewer/2022062409/568150af550346895dbecac0/html5/thumbnails/11.jpg)
2Research
Kung HF, et al, J Nucl Med, 2011, 52(12):1947-55.
![Page 12: PET Imaging of Glutaminolysis in Tumors by 18 F-(2S,4R)4-Fluoroglutamine](https://reader036.vdocuments.us/reader036/viewer/2022062409/568150af550346895dbecac0/html5/thumbnails/12.jpg)
2Research
Kung HF, et al, J Nucl Med, 2011, 52(12):1947-55.
![Page 13: PET Imaging of Glutaminolysis in Tumors by 18 F-(2S,4R)4-Fluoroglutamine](https://reader036.vdocuments.us/reader036/viewer/2022062409/568150af550346895dbecac0/html5/thumbnails/13.jpg)
2Research
Kung HF, et al, J Nucl Med, 2011, 52(12):1947-55.
![Page 14: PET Imaging of Glutaminolysis in Tumors by 18 F-(2S,4R)4-Fluoroglutamine](https://reader036.vdocuments.us/reader036/viewer/2022062409/568150af550346895dbecac0/html5/thumbnails/14.jpg)
2Research
Kung HF, et al, J Nucl Med, 2011, 52(12):1947-55.
![Page 15: PET Imaging of Glutaminolysis in Tumors by 18 F-(2S,4R)4-Fluoroglutamine](https://reader036.vdocuments.us/reader036/viewer/2022062409/568150af550346895dbecac0/html5/thumbnails/15.jpg)
Conten
ts:
1 Background 2 Research3 Summary 4Development
![Page 16: PET Imaging of Glutaminolysis in Tumors by 18 F-(2S,4R)4-Fluoroglutamine](https://reader036.vdocuments.us/reader036/viewer/2022062409/568150af550346895dbecac0/html5/thumbnails/16.jpg)
3Summary
The results support the feasibility of PET for the study of a fundamental change in tumor metabolism---high-rate glutaminolysis.
1 In vitro tumor cell uptake of 18F-(2S,4R)4-Fluoroglutamine is higer than uptake of 18F-FDG.
2In vivo PET studies showed significant tumor uptake adnd trapping inside tumor tissue in 2 different tuor models.
3
![Page 17: PET Imaging of Glutaminolysis in Tumors by 18 F-(2S,4R)4-Fluoroglutamine](https://reader036.vdocuments.us/reader036/viewer/2022062409/568150af550346895dbecac0/html5/thumbnails/17.jpg)
Conten
ts:
1 Background 2 Research3 Summary 4Development
![Page 18: PET Imaging of Glutaminolysis in Tumors by 18 F-(2S,4R)4-Fluoroglutamine](https://reader036.vdocuments.us/reader036/viewer/2022062409/568150af550346895dbecac0/html5/thumbnails/18.jpg)
4Development
Kung HF , et al, Chemistry. Science, 2013 , 342(6157):429-30.
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4Development
![Page 20: PET Imaging of Glutaminolysis in Tumors by 18 F-(2S,4R)4-Fluoroglutamine](https://reader036.vdocuments.us/reader036/viewer/2022062409/568150af550346895dbecac0/html5/thumbnails/20.jpg)
THANK THANK YOUYOU
TT
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Q&A