peroxisomas. page 721 molecular biology of the cell (© garland science 2008)

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Page 1: Peroxisomas. Page 721 Molecular Biology of the Cell (© Garland Science 2008)

Peroxisomas

Page 2: Peroxisomas. Page 721 Molecular Biology of the Cell (© Garland Science 2008)

Page 721 Molecular Biology of the Cell (© Garland Science 2008)

Page 3: Peroxisomas. Page 721 Molecular Biology of the Cell (© Garland Science 2008)
Page 4: Peroxisomas. Page 721 Molecular Biology of the Cell (© Garland Science 2008)

RH2 + O2 → R + H2O2

R’H2 + H2O2 → R’+2H20

2 H2O2→2 H2O+ O2

Generan H2O2 (oxidación) y

destruyen el exceso (catalasa)

Page 5: Peroxisomas. Page 721 Molecular Biology of the Cell (© Garland Science 2008)

Beta oxidación

CH3- CH- CH2- CH2- CH2- CH2- CH2- CH2- CH2-C~SCoA

CH3-C~SCoA

Page 6: Peroxisomas. Page 721 Molecular Biology of the Cell (© Garland Science 2008)

Figure 12-31 Molecular Biology of the Cell (© Garland Science 2008)

Plasmalógeno

Page 7: Peroxisomas. Page 721 Molecular Biology of the Cell (© Garland Science 2008)

Secuencia de importación: Ser-Lys-Leu (C-term)

Peroxinas

Page 8: Peroxisomas. Page 721 Molecular Biology of the Cell (© Garland Science 2008)

Figure 12-33 Molecular Biology of the Cell (© Garland Science 2008)

Page 9: Peroxisomas. Page 721 Molecular Biology of the Cell (© Garland Science 2008)

Retículo Endoplasmático

Page 10: Peroxisomas. Page 721 Molecular Biology of the Cell (© Garland Science 2008)

Figure 12-4a Molecular Biology of the Cell (© Garland Science 2008)

Page 11: Peroxisomas. Page 721 Molecular Biology of the Cell (© Garland Science 2008)
Page 12: Peroxisomas. Page 721 Molecular Biology of the Cell (© Garland Science 2008)

Figure 12-36c Molecular Biology of the Cell (© Garland Science 2008)

Page 13: Peroxisomas. Page 721 Molecular Biology of the Cell (© Garland Science 2008)
Page 14: Peroxisomas. Page 721 Molecular Biology of the Cell (© Garland Science 2008)

Figure 12-35 Molecular Biology of the Cell (© Garland Science 2008)

Page 15: Peroxisomas. Page 721 Molecular Biology of the Cell (© Garland Science 2008)

Figure 12-36b Molecular Biology of the Cell (© Garland Science 2008)

Page 16: Peroxisomas. Page 721 Molecular Biology of the Cell (© Garland Science 2008)

Figure 16-77a Molecular Biology of the Cell (© Garland Science 2008)

Page 17: Peroxisomas. Page 721 Molecular Biology of the Cell (© Garland Science 2008)
Page 18: Peroxisomas. Page 721 Molecular Biology of the Cell (© Garland Science 2008)

Figure 12-37b Molecular Biology of the Cell (© Garland Science 2008)

Page 19: Peroxisomas. Page 721 Molecular Biology of the Cell (© Garland Science 2008)

Péptido señal

Receptor de translocación

Page 20: Peroxisomas. Page 721 Molecular Biology of the Cell (© Garland Science 2008)

Figure 12-38 Molecular Biology of the Cell (© Garland Science 2008)

Page 21: Peroxisomas. Page 721 Molecular Biology of the Cell (© Garland Science 2008)

Figure 12-39b Molecular Biology of the Cell (© Garland Science 2008)

Page 22: Peroxisomas. Page 721 Molecular Biology of the Cell (© Garland Science 2008)

Figure 12-40 Molecular Biology of the Cell (© Garland Science 2008)

Page 23: Peroxisomas. Page 721 Molecular Biology of the Cell (© Garland Science 2008)

Figure 12-41a Molecular Biology of the Cell (© Garland Science 2008)

Page 24: Peroxisomas. Page 721 Molecular Biology of the Cell (© Garland Science 2008)

Figure 12-46 Molecular Biology of the Cell (© Garland Science 2008)

Soluble Transmembrana

Page 25: Peroxisomas. Page 721 Molecular Biology of the Cell (© Garland Science 2008)

Figure 12-45 Molecular Biology of the Cell (© Garland Science 2008)

Page 26: Peroxisomas. Page 721 Molecular Biology of the Cell (© Garland Science 2008)

Figure 12-46 Molecular Biology of the Cell (© Garland Science 2008)

Paso único

Page 27: Peroxisomas. Page 721 Molecular Biology of the Cell (© Garland Science 2008)

Figure 12-47 (part 1 of 2) Molecular Biology of the Cell (© Garland Science 2008)

Page 28: Peroxisomas. Page 721 Molecular Biology of the Cell (© Garland Science 2008)

Figure 12-47 (part 2 of 2) Molecular Biology of the Cell (© Garland Science 2008)

Page 29: Peroxisomas. Page 721 Molecular Biology of the Cell (© Garland Science 2008)

Figure 12-48 Molecular Biology of the Cell (© Garland Science 2008)

Doble paso

Page 30: Peroxisomas. Page 721 Molecular Biology of the Cell (© Garland Science 2008)

Figure 12-44 Molecular Biology of the Cell (© Garland Science 2008)

Proteínas residentes en el RE

• Poseen señal de retención

• Proteína disulfuro isomerasa, Chaperona BIP

Page 31: Peroxisomas. Page 721 Molecular Biology of the Cell (© Garland Science 2008)

Figure 12-56 Molecular Biology of the Cell (© Garland Science 2008)

Anclaje glicosilfosfatidilinositol (GPI)

Page 32: Peroxisomas. Page 721 Molecular Biology of the Cell (© Garland Science 2008)

Figure 12-50 Molecular Biology of the Cell (© Garland Science 2008)

Glucosilación (N-oligosacárido)

Page 33: Peroxisomas. Page 721 Molecular Biology of the Cell (© Garland Science 2008)

Figure 12-51 Molecular Biology of the Cell (© Garland Science 2008)

Page 34: Peroxisomas. Page 721 Molecular Biology of the Cell (© Garland Science 2008)

Figure 12-53 Molecular Biology of the Cell (© Garland Science 2008)

Calnexina

Calreticulina

Page 35: Peroxisomas. Page 721 Molecular Biology of the Cell (© Garland Science 2008)

Figure 12-50 Molecular Biology of the Cell (© Garland Science 2008)

Glucosilación (N-oligosacárido)

Page 36: Peroxisomas. Page 721 Molecular Biology of the Cell (© Garland Science 2008)

Figure 12-54 Molecular Biology of the Cell (© Garland Science 2008)

Exportación de proteínas mal plegadas

Page 37: Peroxisomas. Page 721 Molecular Biology of the Cell (© Garland Science 2008)

Figure 12-55a Molecular Biology of the Cell (© Garland Science 2008)

Page 38: Peroxisomas. Page 721 Molecular Biology of the Cell (© Garland Science 2008)

Figure 12-55b Molecular Biology of the Cell (© Garland Science 2008)

Page 39: Peroxisomas. Page 721 Molecular Biology of the Cell (© Garland Science 2008)

Figure 10-2 Molecular Biology of the Cell (© Garland Science 2008)

Síntesis de membrana en RE

Page 40: Peroxisomas. Page 721 Molecular Biology of the Cell (© Garland Science 2008)

Figure 12-57 Molecular Biology of the Cell (© Garland Science 2008)

Síntesis de fosfatidilcolina en el RE (cara citosólica)

Page 41: Peroxisomas. Page 721 Molecular Biology of the Cell (© Garland Science 2008)

Figure 12-58 Molecular Biology of the Cell (© Garland Science 2008)