periodontology chi-cheng tsai, d.d.s., ph.d. professor of periodontology and oral pathology college...
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Periodontology
Chi-Cheng Tsai, D.D.S., Ph.D.
Professor of Periodontology
and Oral Pathology
College of Dental Medicine
Kaohsiung Medical University
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Periodontal Pathogenesis
• General Objective: To correlate the clinical characteristics of inflammatory periodontal disease with the underlying histopathological changes.
• Specific Objectives: 1. To acquire basic terminology dealing with periodontal pathology. 2. To list in a step-wise fashion the clinical and histopathological changes occuring during inflammatory periodontal disease. 3. Differentiate between a sulcus and a pocket. 4. Discuss the pathology of inflammatory responses.
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Periodontal Pathogenesis (contd.)
5. To recognize those factors which can alter
the pathogenesis of periodontal disease.
a. To identify the local environmental
factors which may enhance or inhibit
the expression of bacterial pathogenicity.
b. To list the central factors governing
metabolism of host tissues which may
condition the response to bacterial products.
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Healthy Periodontium
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Healthy Periodontium
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Healthy Periodontium
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Healthy Periodontium
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Periodontium
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Periodontal structure(ref.2, page 1)
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Periodontal structureref.1-1
• Facial interdental papilla• Junctional epithelium• Slucus• Free gingiva• Attached gingiva• Mucogingival line• Alveolar mucosa• PDL• Alveolar bone/Cribriform plate• Lingual plate of bone• Trabeculae (Cancellous bone)
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Variability of gingival width(ref.2, page3)
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Iodine test (Schiller 0r Lugol solution)
( oral mucosa: brown color (glycogen +), attached gingiva : unstained)
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Top: Attachment loss (recession), toothbrush injury. Bottom: Roll testref.1-
120
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Col(ref. 1, page 3)
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Periodontiumref.4-227
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Gingival and periodontal bundles, cementum, alveolar bone (ref. 1, page 6)
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Bony support apparatus(ref. 1, page 8)
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Bony support apparatus
• 1. alveolar bone: cribriform plate, alveolar
wall, lamina dura (radiograph).
2. trabecular bone.
3. compact bone.
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Periodontal blood: from 1(periodontal ligament0, 2(alveolar process, 3(supraperiosteal & mucogingival tissues).(ref.1, page10)
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Periodontal Probesref.1-118
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Probes for diagnosis of furcations and root irregularitiesref.1-118
• CH 3: fine and pointed, paired left and right, curved. For surfaces and narrow grooves.• Nabers 2: Blunt, paired left and right, curved. For probing furcations.• CP 12: Periodontal probe for horizontal measurement of furcation involvement (Hu-Friedy).
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Healthy Crevice
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Inflamed Gum with Normal PPD
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Normal PPD and CAL
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Periodontal Disease
1. Periodontal disease usually means the destructive inflammatory process affecting one or more of the four components of the periodontium.
a). Alveolar bone
b). Cementum
c). Periodontal ligament proper
d). Gingiva
2. Periodontal diseases are among the most common affections of mankind
3. Epidemiological surveys suggest that essentially all the world’s populations have experienced some forms of periodontal disease.
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Stage Four Periodontal Disease
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Classification of pockets ref.1:77
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Pocket Depth/Recession
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PPD and CALref.1-117
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PPD and CAL
• A. a 6-mm probing depth results from
3 mm of attachment loss and 3 mm of
hyperplastic tissue.
• B. a 6-mm pocket results from 6 mm of
attachment loss.
• C. a 6-mm pocket with 9 mm of
attachment loss.
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Pocket Depth:Recession
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Pocket Depth and Recession
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Infrabony Pocketsref.2-58
• 3-wall bony pockets: one tooth surface and three osseous surfaces.• 2-wall bony pockets (interdental crater): two tooth surfac
es and two osseous (one facial & one oral).• 1-wall bony pockets: two tooth surfaces, one osseous su
rface (facial or lingual), a soft tissue border.• Crater (Cup) defects: a combined form of pocket, defect surrounds the tooth.
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Infrabony Pocketsref.1,page 78
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Small 3-wall Pocketref.1-78
(3mm)
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Deep 3-wall Bony Pocketref.1-78
(6 mm from the crest)
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2-wall Bony Pocketref.1-79
(interdental crater, apical 3-wall defects)
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1-wall Bony Defectref.1-79
(lingual plate remains)
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Combined Pocketref.1-79
( crater defect, a cup)
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Buccal Furcation-bref.1-119
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Mesial Furcation-mref.1-119
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Distal Furcation-dref.1-119
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Classification of furcation involvementref.2-60
• F0: pocket, but without furcation involvement• F1: furcation can be probed 3 mm in horizontal direction• F2: furcation can be probed deeper than 3 mm• F3: through-and through furcation involvement
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Classification of furcation ref. 1,80
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F0: No Furcationref.1-80
(could have ca. 5 mm suprabony pocket)
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F0: No Furcationref.1-80
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F1 : Furcation 1ref.1-80
(< 3mm, performed from both lingual and buccal aspects)
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F1: Furcation 1ref.1-80
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F2: Furcation 2ref.1-81
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F2: Furcation 2ref.1-81
(can probe more than 3 mm but not yet through-and through)
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F3: Severe Furcationref.1-81
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F3: Furcationref.1-81
(wide through-and-through, vertical bone loss >6mm)
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Furcation Involvement
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Degrees of Tooth Mobility
(500 g labio-lingual force)
0 = normal (physiologic mobility).
1 = detectably increased mobility.
2 = visible mobility up to 0.5 mm.
3 = severe mobility up to 1 mm.
4 = extreme mobility, vertical mobility, no
longer functional.
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Bacteria: Periodontal Diseases
Bacteria as primary etiologic agents in periodontal disease.
experimental and epidemiologic studies: bacteria are required for initiation and perpetuation of inflammatory and destructive periodontal disease.
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Bacteria: Dental Disease
1. Germ-free (gnotobiotic) animals do not have periodontitis or caries.
2. Animals and man in whom the oral flora has been mechanically and chemotherapeutically removed or suppressed, show disease remission.
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Gnotobiotic Rat: Experimental Periodontitisref.7-378
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Gnotobiotic Rat: Experimental Periodontitisref.7-378
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Normal Histology
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Histology: Experimental Periodontitis (Rat)
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Experimental Gingivitis
Initial gingivitisLöe et al. (1965): Experimental gingivitis• Bacterial etiology of gingivitis (a) Plaque free stage (b) Oral hygiene ceased stage Gram-positive cocci and rods filamentous organisms spirochetes—mild gingivitis (GI=1)
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Experimental Gingivitis
• Free from plaque remain periodontally healthy
• Established periodontal disease can be arrested by meticulous scaling and root planing, proper oral hygiene
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Prophylaxis
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Scalingref.4-135
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Chronic Periodontitis
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After Scaling and Root Planing
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Scaling and Root Planing
• Combined effect of subgingival scaling and controlled oral hygiene definitely reduced the incidence of gingivitis
• How gingivitis develops?: experimental gingivitis (Löe, 1965)
Bacterial plaque—main aetiological factors
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Microorganisms and Periodontal Disease
3) Microorganisms in various stages of
periodontal disease
4) Microorganisms in various types of
periodontal disease
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Microbiota in different stages of periodontal disease
1. Healthy gingiva:
• Supragingival plaque: relatively few cells
• predominate by G(+) mainly streptococci and Actinomyces species
• Spirochetes and vibriolike are low number
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Microbiota in different stages of periodontal disease
2. Initial-early gingivitis:
• Decreased Streptococci
• Increased Actinomyces and rods
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Microbiota in different stages of periodontal disease
3. Established gingivitis:
subgingival plaque
• G(+): Actinomyces
• G() increased: Rods and spirochetes
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Microbiota in different stages of periodontal disease
4. Destructive periodontitis:
(gingivitis with loss of attachment)
• Microbiota are as in established stage
(may be greater increase in G() bacteria)
• Microbial invasion of connective tissue including bone and periodontal ligament has been reported.
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Normal Dental Plaqueref.8-170
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Chronic Gingivitis from Dr. Listgarten,1976
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Periodontitis: test tube brush, and of spirochetes (from Dr. Listgarten,1976; ref.5-97)
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RPP: Test tube brush, sea of spirochetesref.8-154,ref.5-132
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Prominent Cultivable Microorganisms Associated with Various Periodontal Conditions
• Periodontal condition A B C D E F• Healthy periodontium 7 12.7 n.d. 9.5 35.1 39.8• Gingivitis 9 25.0 14.8 9.2 16.9 26.5• Advanced periodontitis 8 74.3 n.d. 15.1 2.9 6.2• Juvenile periodontitis• Deep pockets 8 59.3 4.5 15.3 3.1 10.2• Normal pockets 8 27.4 8.4 7.3 11.8 37.2
• A: Number of samples; B: % G(-) anaerobic flora; C:% G(-) facultative anaerobic flora; D:% G(+) anaerobic flora; E: % G(+) facultative anaerobic flora; F: % G(+) facultative anaerobic cocci.
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Characterization of Subgingival Plaque
• Clinical health: G(+), Streptococci
• G(-) facultative-anaerobic rods 40% in chronic gingivitis
65-75% in chronic periodontitis
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Oral Microfloraref.1-19
• Gram(+) Gram(-)• Facultative anaerobes Anaerobes Facultative anaerobes Anaerobes• Streptococcus Peptostreptococcus Neisseria Veillonella• S. mutans Peptococcus Branhamella V. alcalescens• S. sanguis Streptococcus V.atypica• S. salivarius V. paruvula• S. milleri• S. mitis• Micrococcus• Actinomyces Actimyces Actinobacillus Bacteroides• A. naeslundii A. israelii A. actimycetem- B. gingivitis• A. viscosus A. odontolyticus comitans B. intermedius• Bacterionema Arachinia Capnocytophaga B. forthythus R
othia Eubactrium C. gingivalis B. melanino.
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Oral Microfloraref.1-19
• Gram(+) Gram(-)Facultative Anerobes Facultative anerobes Anerobesanaerobes
Nocardia Propionibacterium C. ochracea B. loescheii
Lactobacillus Bifidobacterium C. sputigena B. denticola L. acidophilus Eikenella B. corporis L. casei E. corrodens Fusobacterium L. fermentum Haemophilus Leptotrichia• H. segnis Campylobacter• Selenomonas• Wolinella
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Spirochetes and Other Microorganisms
• Treponema– T. vincentii– T. denticola– T. socranskii
• Mycoplsasma• Candida
– C. albicans
• Entamoeba• Trichomonas
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Bacteria: Pathogenic Theory
1. Sufficient numbers of a pathogenic species
2. Access to the target tissues
3. Organisms are able to survive and multiply
4. No or in low number of inhibiting organisms
5. Susceptible host
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Relative number of publications suggesting the role of additional species possible etiologic agents of destructive periodontitis
• Species Association Elimination Host Virulence Animal• Response Factors Studies• P. intermedia +++ ++ ++ +++ +++• F. nucleatum +++ + +++ ++ +• B forsythus +++ + + --- +• C. rectus +++ ++ --- --- ---• E. corrodens +++ + --- + ++• P. microbs +++ + + --- ---• Selenomonas sp. +++ --- --- --- ---• Eubacteriun sp. ++ --- ++ --- ---• Spirochetes +++ +++ +++ +++ +• ___________________________________________________________________• Modified from Socrasky and Haffajee (1990, 1991, 1992).
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Microbial Composition of Subgingival Plaque in Healthy
Gingiva• Sparse• G(+) saccharolytic• Gingival crevice has a low redox potential, a pH
of around (or just below) neutrality• Obligatory anaerobic species• Recovered on occasions: spirochetes, some bla
ck-pigmented anaerobes• Isolated infrequently and in relatively low number
s: A.a. and P.g.
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Subgingival Plaque: Gingivitis
• An increase in mass• A shift from a Streptococcus-predominated micr
oflora to one with higher proportions of Actinomyces
• Increased proportions of F. nucleatum and P. intermedia
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Gingivitis: Subgingival Plaque
• A. actinomycetemcomitans in low number, P. gingivalis rarely isolated.
• Gingivitis may favor the growth of species implicated in periodontitis.
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Bacteria: ANUG
• Fuso-spirochetal pattern of bacteria
• A heterogeneous collection of cultivable organisms– P. intermedia was isolated commonly– F. nucleatum was only a minor component
• Organisms appear invade host tissue
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Subgingival Plaqueand
Periodontal Disease
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Bacteria: Destructive Periodontal Diseaseref.9-”371-376”
• Dzink et al. 1985: active sites– P. intermedia, B. forsythus, A.a., Wolinella recta– F. nucleatum, P. gingivalis and E. corrodens
• Tanner et al. 1987: – W. recta, B. gracilis and E. corrodens– Proportions of all three species were less than 5%– Viable count at sites (active/inactive) overlapped
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Bacteria: LJP
• Microflora is sparse with relatively few species
• A. actinomycetemcomitans (A.a.) (most produces a leukotoxin)
• Elevated antibody level to A.a.
• Some LJP sites had no A.a. been isolated
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LJP: active pocket
• Mandell, 1984– E. corrodens and A.a. elevated– P. intermedia, F. nucleatum, Capnocytophaga
decreased slightly, or not significantly increased
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Adult (Chronic) Periodontitis
• Microflora is difficult to define
• Diverse collections of microorganisms
• A progressive change in the composition of the microflora
• Burst of disease activity
• Microflora from “active” and “inactive” periodontitis sites
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Chronic Periodontitis
• Haffajee et al. 1988– Predominant species in active lesions: F. nucl
eatum, Bacteroides spp., G(+) rods and Streptococci in other cases
– Many microbiologically distinct forms of periodontal disease
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A.a.,P.g., P.i.
• Slots et al. 1986– A.a. P.g. P.i. as being of particular
significance in the etiology– One or more of the above species were
isolated from 99% of progressive (active) sites, only about 40% of untreated non-progressive sites
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Bacteria and Periodontitis
• Wennström et al. 1987– Sites with one or more of the three (A.a. P.g.
P.i.) species– All three organisms were absent– The absence of these three “indicator” bacteri
a appears to be a better predictor of no further loss of attachment than the presence of them is for disease progression.
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Active vs. Inactive Lesion
• Progression of periodontal breakdown
• A limited number of true “pathogens”
• Proposed organisms as being associated with “active” lesions
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Bacteria associated with ”active” periodontal lesions in humans
Destructive periodontal disease
W. recta
B. fracilis
E. corrodens
Tanner et al. (1987)
Recurrent periodontitis
B. forsythus Lai et al. (1987)
Localized and generalized destructive periodontal disease
F. nucleatum (miscellaneous spp.)
Haffajee et al. (1988c)
The nomenclature is that of the original investigator(s).ref. 9-372
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Pathways of Tissue Alteration
1. Displacement of the JE from tooth surface: enzymatic activity
2. Leukotoxins: hamper the functioning normal defense mechanisms
3. Activation of acute inflammation and immunopathologic processes
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Bacteria reported to be associated with various types of periodontitis
• I. Frequently reported:• Porphylomonas gingivalis• Actinobacillus actinomycetemcomitans• Spirochetes (Treponema spp.)
• II. Occasionally reported:• Prevotella intemedia, P. denticola, P. oralis, P meloninogenica.• Bactereroides forsythus, B, gracillis.• Fusobacterium nucleatum, F. alocis, F. periodoticum.• Eikenella corrodens, Wolinella recta, Selenomonas spp., Capno-• cytophga spp., Treponema denticola, • F. brachy, F. nodatium, F. tinidum
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Complexes of Periodontal Pathogens
• Yellow complex: S, mitis, S. oralis, S. sanguis; S. gordonii, S. intermedius.
• Purple complex: V. parvula, A. odontolyticus.• Green complex: E. corrodens, Capnocytophaga
spp.,A. actinomycetemcomitans.• Orange complex: P. intermedia, P. nigrescens, P.
micros, F. nucleatum; C. rectus, E. nodatum, C. showae.
• Red complex: P. gingivalis, B. forsythus, T. denticola.(more often in POB sites).
(adapted from Carranza’s Clinical Periodontology, 9th ed., page104)
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Periodontopathogens
• 牙周炎相關菌種 (I) 非常強烈 /強烈相關者 (Very strongly/strongly associate
d)– Actinobacillus actinomycetemcomitans– Porphyromonas gingivalis– Bacteroides forsythus (Tanerella forsythensis)– Prevotella intermedia– Campylobactor rectus– Eubacterium nodatum– Treponema species
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Periodontopathogens
• 牙周炎相關菌種 (II)中等度相關者 (Moderately associated)
– Streptococcus intermedius– Prevotella nigrescens– Peptostreptococcus micros– Fusobacterium nucleatum– Eubacterium species– Eikenella corrodens
2
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Periodontopathogens
• 牙周炎相關菌種 (III)– Species are essential for initiation– Consequences of a sequential infection (multi
ple species)– Consequences of overgrowth of commensal p
eriodontal microflora or exogenous infections– Microbial transmission among family member
s
3
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Periodontopathogens
4
• 牙周炎相關菌種 (IV)– Presence of a “pathogenic” flora and disease
status– Threshold for disease activity
• Combination or not with other strains• Virulent or avirulent• Environmental and ecology
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Environmental Modification of the Virulence Potential of Subgingival Plaque
• Microflora is a dynamic balance with the host• The origin of the suspected periodontopathogens• Plaque accumulates and causes an inflammatory
response• Enrichment of species (associated with periodontal
disease)• Numbers (infectious dose) of a pathogen(s)• The pocket environment
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Pathogenic Synergy in the Etiology of Periodontal Diseasesref.9-380
• Bacteria capable of causing tissue damage directly (e.g. X,Y & Z) may be dependent on the presence of other cells (C or D) for essential nutrients or attachment, so that they can grow and resist the removal of GCF.
• Similarly, both groups of bacteria may be reliant for their survival on other organisms (Z,A or B) to modulate the host defenses.
• Individual bacteria may have more than one role (e.g.organism Z) in the etiology of disease, while different species could have similar role in different sites or subjects.
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Pathogenic synergy in the etiology of periodontal diseasesref.9-380
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Microbial Succession in Periodontal Diseaseref.9-382
• Periodontal pathogens (closed symbols) in low number at healthy sites, but too low to cause disease; some pathogens may be acquired exogenously.
• Changes to the site ( altered nutrient availability; pH, reduced host resistance, etc.) may provide the opportunity for the outgrowth of some pathogens; this may further alter the environment and favor other organisms so that waves of microbial succession may occur.
• Depending on the original microflora of the pocket and on the sequence of environmental changes, then a range of microflora with disease potential could develop.
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Microbial succession in periodontal diseaseref.9-382
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Microflora of pockets before and after successful treatment, and of the refractory disease
• Sites that lost attachment after therapy– A.a., B. forsythus, P. gingivalis, P. intermedia,
P. melaninogenica, Peptostreptococcus micros, S. intermedius and W. recta
– Spirochetes and P. gingivalis showed a strong correlation with the continued loss of attachment
– Decreased proportion of P. gingivalis is positively correlated with the reduction of pocket depth
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Mechanisms
• Bacterial products act directly on bone to cause resorption
• Bacteria and endotoxins
cemental surface
inhibit reattachment potential
continuous pathologic tissue change
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Bacterial Factors (I)
• Function Specific Factors• Adherence Adhesins (fimbriae, fibrils)• Evasion of host defense Capsules, Slime layers,• mechanisms Leukotoxin, Immunoglobulin proteases, • Complement proteases,• Supression of T-cells.
• Direct tissue damage Enzymes: trypsin-like protease, • chymotrypsin, collagenase, hyaluronidase, • chondroitin sulphatase, heparinase.• • Metabolic products(Cytotoxins):• volatile fatty acid (butyric acid & • propionic acid), indole, ammonia, amines, • volatile sulphur compounds.•
•
•
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Bacterial Factors (II)
Induction of bone resorption Lipoteichoic acid
Lipopoysaccharide
Capsules
Indirect tissue damage Antigenic stimulation leading to
immune responses and
inflammation
Interleukin productin and proteinase
synthesis in response to plaque
antigens
Activation of alternative complement
pathway
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Bone Resorptionref.1-30
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Clinical and Histopathological Features of Periodontal Diseas
e
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Developmental Stages of Periodontal Disease
• Clinically healthy gingival tissue:– Very small areas of less dense collagen tissu
e adjacent to JE– Light infiltration with lymphocytes and monocy
tes– Less than 10% are PMNs and plasma cells
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Healthy Gingivaref.1-22
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Stages of Periodontal Disease
• Initial lesions: 2-4 days after plaque accumulation
– Swelling of vascular plexus with leakage of PMNs into tissues
– Dilated intercellular spaces are observed– Collagen destruction begins perivascularly
Page and Schroeder
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Stages of Periodontal Disease
• Early lesion (occurs 4-7 days after plaque accumulation)– Connective tissue adjacent to JE becomes
infiltrated by lymphocytes (primarily)– Loss of collagen fibers occurs in infiltrated
areas– JE becomes disrupted due to underlying
infiltration and begins to desquamate more rapidly into sulcus
Page and Schroeder
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Initial / Early Gingivitisref.1-22
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Stages of Periodontal Disease
• Established Stage(I week after plaque accumulation)
– Extension of infiltrated collagen-poor connective tissue
– Cellular component of infiltrate: • decrease in lymphocytes (B>T)• increase in plasma cells and immunologically differe
ntiating blast cells
– Ulceration and extensive rete peg proliferations, thinning of sulcular epithelium
– Can persist for years without progressing
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Established Gingivitisref.1-23
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Advanced stage: periodontitisref.2-19
• Adherent gram +, non-adherent gram – (pocket) bacteria• Apical proliferation of pocket epithelium, true pocket form
ation; ulceration of pocket epithelium• Acute inflammatory responses as in gingivitis; predomina
nce of plasma cells; exudate often suppurative; expansion of inflammatory and immunopathologic reactions
• Further collagen loss in the infiltrated tissues,• Loss of alveolar bone (attachment loss)• Periods of quiescence and exacerbation• Progression: chronic (slow), aggressive (rapid, RPP,JP)
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Advanced Stage: Periodontitisref.1-23
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Advanced Stage: Periodontitisref.1-24
(blue arrows: exudate, PMNs; red: sloughing JE cells)
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Periodontitisref.1-24
• Proliferation and apical expansion of bacterial plaque
• Formation of a true periodontal pocket
• A change in the direction of flow of the exudate from the infiltrate perpendicularly toward the plaque-covered tooth surface
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Periodontitis
• Proliferation and apical expansion of bacterial plaque: periodontal pocket
• Change in the direction of flow of exudate: from the infiltrate perpendicularly toward the plaque-covered tooth surface (blue arrows: exudate,PMNs; red arrows: sloughing JE cells).
• Epithelial attachment has been forced apically.
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Cyclic Nature of Periodontitis
• Acute episodes of tissue destruction– G(-) anaerobic motile bacteria– Direct invasion of microorganisms– Tissue response: formation of mininecrosis or absces
ses– Loss of attachment
• Periods of relative dormancy : host response can eliminate bacterial insult and lead to stagnation of the acute exacerbation. A certain degree of regeneration may occur.
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Initial gingivitis ref.2, page 10
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Cyclic Nature
• Increased in pathogenic bacteria in subgingival plaque: tissue evasion: acute inflammation within the periodontium(red arrows): attachment loss and bone resorption.
• An enhanced host response can eliminate the bacterial insult: stagnation of the acute exacerbation: tissue regeneration may occur.
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Gingivitis
• The most prevalent and mildest manifestation of periodontal disease
• Associated with bacterial plaque• Limited to inflammation of the marginal
gingiva, no loss of attachment of the periodontal tissues
• Gingival enlargement-increased sulcus depth, reversible if properly treated
• Can remain stable for many years
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Dental Plaque: Gingivitis
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Stained Plaque: Gingivitisref.1-47
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Subgingival Calculusref.1-14
(lt. formerly subg. calculus is now supg., reflecting the gingiva reveals the subg. Calculus)
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Necrotizing Gingivitis
• Manifest initially as necrosis of gingiva (apex of the pyramidal interdental papilla)
• Ulcerated craters, overlying necrotic tissues
• Tender, low-grade fever, general malaise, halitosis
• Spirochetes superimposed by other microorganisms
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ANUG
• Thought of as “fuso-spirochetal” in origin
• High levels of Treponema (32%) and Selenomonas (6%)
• Viable count: significant levels of Bacteroides (Prevotella) intermedia (24%) and Fusobacterium spp. (3%)
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Four Zones of ANUG
• Zone 1: bacterial zone, the most superficial
• Zone 2: neutrophil-rich zone
• Zone 3: nccrotic zone, disintegrated tissue cells
• Zone 4: zone of spirichetal infiltration, intermediate-sized and large types of spirochetes
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Severe ANUGref.1-53
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ANUGref.1-51
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ANUGref.1-51
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Herpetic Gingivostomatitis
• Children and young adults
• Fever, painful swelling of lymph nodes
• Acute, painful gingivitis with blister-like aphthae
• Predisposing factors
• Spontaneous healing within 1-2 weeks
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Herpetic Gingivostomatitisref.1-69
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Severe Herpetic Gingivostomatitis
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Chronic Gingivitis
• A balance is established between the organisms in the gingival sulcus and local inflammatory defense systems
• Upset of equilibrium:– Allow disease to advance in an apical
direction
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Periodontitis
• Apical down growth of plaque
• Expansion of the zone of collagen loss of periodontal fiber attachment
• Deepening of the gingival sulcus periodontal pocket
• Proliferation of the dentogingival epithelium
• Pocket epithelium
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Periodontitis (contd.)
• Continuous traffic of PMNs
• Continuous outpouring of plasma proteins
• Extension of inflammatory cell infiltrate
• Activation of osteoclasts
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Symptoms of Periodontitis
• Further symptoms of periodontitis• Gingival swelling• Pocket activity: bleeding, exudate and pus• Pocket abscess; furcation abscess• Fistula• Gingival shrinkage (recession)• Tooth migration, tipping, extrusion• Tooth mobility• Tooth loss
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Chronic Periodontitisref.4-112
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Chronic Periodontitis
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Rapidly Progressive Periodontitis (RPP)
• 20-30 years of age, females more often • All teeth may be involved• Some authors called postjuvenile periodon
titis• Mainly vertical bone loss in advanced case
s• Acute stages with specific anaerobes (inva
sion): A.a., P.g.• PMN and monocyte defects
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RPP
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RPP
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X-ray Films: RPP
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Juvenile Periodontitis
• Begins around age of puberty
• Bilaterally symmetric semilunar bone loss– LJP: permanent incisors and first molars– GJP: disseminated LJP?
• Tooth mobility, pathologic migration
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JP: Calculus, Plaque, Severe Gingivitisref.1-96
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JP: 9mm Probing Depthref.2-68
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Radiographs: JP
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LJP: Maxillary Molarsref.1-96
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Classification
• Classification of Periodontal Diseases and Conditions
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Classification System:1989ref.3-1
• Shortcomings– Considerable overlap in disease categories– Absence of a gingival diseases component– Inappropriate emphasis on age of onset of
disease and rates of progression– Inadequate or unclear classification criteria
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Changes in the Classification System for Periodontal Diseasesref.3-1
• Addition of a Section on “Gingival Diseases”.• Replacement of “Adult Periodontitis” with “Chronic
Periodontitis”.• Replacement of “Early-Onset Periodontitis” with
“Aggressive Periodontitis”.• (Contd.)
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Changes in the Classification System for Periodontal Disease ref.3-4
*Clarification of the designation periodontitis as a menifestation of systemic disease.
*Replacement of necrotizing ulcerative periodontitis with necrotizing periodontal diseases.*Addition of a category on periodontal absces
s.*Addition of a category on developmental or a
cquired deformities and conditions.
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Classification System for Periodontal Diseases and Conditionsref.3-2
I. Gingival Diseases
A. Dental plaque-induced gingival diseases
1. Gingivitis associated with dental plaque only.
a. without other local contributing factors.
b. with local contributing factors
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Classification (II)ref.3-2
2. Gingival diseases modified by systemic factors a. associated with the endocrine system 1) puberty-associated gingivitis 2) menstrual cycle-associated gingivitis 3) pregnancy-associated gingivitis a) gingivitis b) pyogenic granuloma 4) diabetes mellitus-associated gingivitis
b. associated with blood dyscrasias 1) Leukemia-associated gingivitis 2) Other
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Classification (III)ref.3-2
3. Gingival diseases modified by medications a. drug-influenced gingival diseases 1) drug-influenced gingival enlargements 2) drug-influenced gingivitis a) oral contraceptive-associated gingivitis b) other4. Gingival diseases modified by malnutrition a. ascorbic acid-deficiency gingivitis b. other
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Classification (IV)ref.3-2
B. Non-plaque-induced gingival lesions
1. Gingival diseases of specific bacterial origin
a. Nesseria gonorrhea-associated lesions
b. Treponema pallidum-associated lesions
c. streptococcal species-associated lesions
d. other
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Classification (V)ref.3-2
2. Gingival diseases of viral origin
a. herpesvirus infections
1) primary herpetic gingivostomatitis
2) recurrent oral herpes
3) varicella-zoster infections
b. other
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Classification (VI)ref.3-2
3. Gingival diseases of fungal origin a. Candida-species infections 1) generalized gingival candidosis b. linear gingival erythema c. histoplasmosis d. other4. Gingival lesions of genetic origin a. hereditary gingival fibromatosis b. other
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Classification (VII)ref.3-2
5. Gingival manifestations of systemic conditions a. mucocutaneous disorders 1) lichen planus 2) pemphigoid 3) pemphigus vulgaris 4) erythema multiforme 5) lupus erythematosus 6) drug-induced 7) other
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Classification (VIII)ref.3-2
b. allergic reactions
1) dental restorative materials
a) mercury
b) nickel
c) acrylic
d) other
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Classification (IX)ref.3-2
2) reactions attributable to
a) toothpastes/dentifrices
b) mouthrinses/mouthwashes
c) chewing gum additives
d) food and additives
3) other
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Classification (X)ref.3-2
6. Traumatic lesions (factitious, iatrogenic, accidental)
a. chemical injury
b. physical injury
c. thermal injury
7. Foreign body reactions
8. Not otherwise specified (NOS)
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Classification (XI)ref.3-3
II. Chronic Periodontitis A. Localized B. GeneralizedIII. Aggressive Periodontitis A. Localize B. GeneralizedIV. Periodontitis as a Manifestation of Systemic Diseases
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Periodontitis as a Manifestation of Systemic Diseases (1)ref.3-3
A. Associated with hematological disorders 1. Acquired neutropenia 2. Leukemia 3. OtherB. Associated with genetic disorders 1. Familial and cyclic neutropenia 2. Down syndrome 3. Leukocyte adhesion deficiency syndrome 4. Papillon-Lefèvre syndrome 5. Chediak-Higashi syndrome
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Periodontitis: Systemic Diseases (2)ref.3-3
6. Histiocytosis syndrome
7. Glycogen storage disease
8. Infantile genetic agranulocytosis
9. Cohen syndrome
10. Ehlers-Danlos syndrome (Types IV & VIII)
11. Hypophosphatasia
12. Others
C. Not otherwise specified (NOS)
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Classification (XI)ref.3-3
V. Necrotizing Periodontal Diseases A. Necrotizing ulcerative gingivitis (NUG) B. Necrotizing ulcerative periodontitis (NUP)VI. Abscess of the Periodontium A. Gingival abscess B. Periodontal abscess C. Pericoronal abscess
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Classification (XII)ref.3-3
VII. Periodontitis Assoc. with Endodontic Lesions A. Combined periodontic-endodontic lesionsVIII. Developmental or Acquired Deformities and Conditions A. Localized tooth-related factors that modify or predispose to plaque-induced gingival diseases/periodontitis
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Classification (XIII)ref.3-3
A. Localized tooth-related factors that modify or predispose to plaque-induced gingival diseases/periodontitis
1. Tooth anatomic factors
2. Dental restoration/appliances
3. Root fractures
4. Cervical root resorption and cemental tears
B. Mucogingival deformities and conditions around teeth
1. Gingival/soft tissue recession
a. facial or lingual surfaces
b. interproximal (papillary)
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Mucogingival Deformities and Conditions (contd.)ref.3-3
2. Lack of keratinized gingiva3. Decreased vestibular depth4. Aberrant frenum/muscle position5. Gingival excess a. pseudopocket b. inconsistent gingival margin c. excessive gingival display d. gingival enlargement (I.A.3. I.B.4.)6. Abnormal color
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Mucogingival Deformities and Conditions/Occlusal Traumaref.3-3
C. Mucogingival deformities and conditions on edentulous ridges
1. Vertical and/or horizontal ridge deficiency 2. Lack of gingival/keratinized tissue 3. Gingival/soft tissue enlargement 4. Aberrant frenum/muscle position 5. Decreased vestibular depth 6. Abnormal color
D. Occlusal trauma 1. Primary occlusal trauma 2. Secondary occlusal trauma
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Characteristics Common to All Gingival Diseasesref.3-8
• Signs and symptoms that are confined to the gingiva• Dental plaque: initiates and/or exacerbates the severity• Clinical signs of inflammation• With no loss of attachment or on a stable but reduced pe
riodontium• Reversibility of the disease by removing the etiology(ies)• Possible role as a precursor to attachment loss around t
eeth
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Characteristics of Plaque-induced Gingivitisref.3-9
• Plaque present at gingival margin• Disease begins at the gingival margin• Change in gingival color• Change in gingival contour• Sulcular temperature change• Increased gingival exudate• Bleeding upon provocation• Absence of attachment loss• Absence of bone loss• Histological changes• Reversible with plaque removal
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Plaque-induced Gingivitis on a Reduced Periodontiumref.3-9
• Plaque present at gingival margin• Disease begins at the gingival margin• Change in gingival color• Change in gingival contour• Sulcular temperature change• Increased gingival exudate• Bleeding upon provocation• Histological changes• Reversible with plaque removal
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Plaque disclosureref.2-72
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Stained plaqueref.2-40
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Histology: Gingivitis
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Gingival Disease Modified by Systemic Factorsref.3-2
A. association with the endocrine system1. Puberty-associated gingivitis
2. Menstrual cycle-associated gingivitis
3. Pregnancy-associated gingivitis• Pyogenic granuloma
4. Diabetes mellitus-associated gingivitis
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Systemic Factorsref.3-2
B. Associated with blood dyscrasia
1) leukemia-associated gingivitis
2) other
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Characteristics of Drug-influenced Gingival Enlargementref.3-11
• Variation in interpatient and intrapatient pattern• predilection for anterior gingiva• Higher prevalence in children• Onset within 3 months• Enlargements first observed at the interdental
papilla• Reduction in dental plaque can limit the severit
y of lesion• Must be using phenytoin, cyclosporine A, or ce
rtain calcium channel blockers
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Gingival Diseases: Medicationref.3-11
A. Drug-influenced gingival enlargements– Anticonvulsant– Immunosuppressant– Calcium channel blocker
B. Drug-influenced gingivitis– Oral contraceptive gingivitis
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Pill Gingivitisref.3-12
• Long term, regular use
• Hemorrhage (bleeding upon provocation)
• Mild erythema and edema (change in gingival color)
• Increased gingival exudate
• Duration of drug therapy
• Reversible following discontinuation of pills
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Characteristics of Oral Contraceptive-associated Gingivitisref.3-12
• Plaque present at gingival margin
• Reversible following discontinuation of oral contraceptives
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Pregnancy Gingivitisref.3-10
• Plaque present at gingival margin
• Onset is in pregnant women(2nd or 3rd trimester)
• Reversible at parturition
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Pregnancy Gingivitis
• Frequency: 30-100%
• 2nd month (begin)
8th month (maximum)
• Increased progesterone altering tissue metabolism
• Pregnancy tumor (epulis)
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Mild Pregnancy Gingivitis
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Severe Pregnancy Gingivitis
• Histologic section of gingiva: normal epithelium, a relatively mild inflammatory infiltrate and widely dilated vessels.
• Radiograph of Gravid epulis: some horizontal loss of the crestal compact bone of the interdental septa.
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Severe Pregnancy Gingivitisref.1-56
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Gravid epulis: Severe Pregnancy Gingivitisref.1-56
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Gravid epulisref.1-56
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Gingivitis: (3 months after gingivoplasty;2 months Post-partum)ref.1-56
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Characteristics of Pregnancy-associated Pyogenic granuloma
• Plaque present at gingival margin
• Can occur anytime during pregnancy
• More common in maxilla
• More common interproximally
• Sessile or pedunculated protuberant mass
• Regresses following parturition (ref.3-11)
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Pregnancy-induced Pyogenic granuloma(epulis)ref.6-350
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Pyogenic granuloma
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Characteristics of Leukemia-associated Gingivitisref.3-13
• Gingival lesions are primarily found in acute leukemias
• Enlargement first observed at the interdental papilla
• Reductions in dental plaque can limit the severity of lesion
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Acute Myelocytic Leukemia
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Acute Myelocytic Leukemia
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Acute Myelocytic Leukemia
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Gingival Over-growth Elicited by Drugs
Overgrowth elicited by drugs• Phenytoin
– seizure disorders• Nifedipine
– hypertension, post-myocardial syndrome• Cyclosporine-A:
– immunosuppressive drugs– solid organ and bone marrow transplants
• Others: – Sodium valproate (antiepileptic)– Bleomycin (anticarcinogen)
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Gingival Hyperplasia
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Drug-induced Gingival Enlargementref.6-34
7(dilantin : epilepsy)
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Cyclosporine-induced Gingival Enlargementref.6-348(immunosuppresant)
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Mild Phenytoin-induced Gingival Enlargementref.1-58
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Severe Phenytoin-induced Gingival Overgrowthref.1-58
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Mild to Moderate Nifedipine-induced Gingival Overgrowthref.1-59
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Severe Cyclosporine-A-induced Overgrowthref.1-60
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Nutritional Deficiency
• Severe scorbutics, severe protein/caloric deficiency
• Necrotizing periodontitis and stomatitis
• A weak association– Ascorbic deficiency and periodontal condition
s
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Non-plaque-induced Gingival Lesionsref.3-2
1. Infectious gingivitis
. Viral infections– Herpes simplex virus types 1 and 2– Varicella-zoster virus
. Fungal infections– Candidosis; histoplasmosis
• Bacterial infection– Neisseria gonorrhea
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Herpetic Gingivostomatitisref.2-54
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Candida
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Candidiasis
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Candidiasis
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Gingival lesion of genetic originref.3-2
• Hereditary gingival fibromatosis
• Other
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Hereditary Gingival Hyperplasia
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Idiopathic Gingival and Bone Thickening
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Hypertrichosis: Gingival Fibromatosis
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Hypertrichosis(10 years old boy)
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Non-plaque-induced Gingival Lesionsref.3-2
• Gingival manifestations of systemic conditions
a. Mucocutaneous Disorders– Pemphigoid– Pemphigus vulgaris– Erythema multiforme– Lupus erythematosus– Lichen planus
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Lichen Planusref.1-67
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Reticular Lichen Planus: Wickham’s Striaeref.1-67
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Pemphigoid
• Women beyond middle age
• Oral mucosa, gingiva, conjunctiva, pharynx, skin
• Subepithelial blister
• IgG and C3 deposits on basement membrane
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Pemphigoidref.1-66
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Pemphigus Vulgaris
• Elderly females more often• Mucosal surfaces through the body, skin, oral m
ucosa and gingiva• Intraepithelial vesicles
Rupture
Painful erosions
Epithelial desquamation• Therapy: immunosuppresants and systemic corti
costeroids
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Bullous Pemphigus Lesion
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Erythma multiforme: Crustsref.6-345
(ulceration and crusts of the vermilion part of the lip)
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Primary herpes: palatal gingiva with confluency of the punctiform lesions of a childref.6-336
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Erythema multiformeref.6-345
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Erythema multiforme
• Precipitating factors: herpes simplex infection (the most common) and other infections, drugs.
• In young adults, males• Sloughing of the mucosa, diffuse redness• From small red macules-bullae-rupture-slo
ughing mucosal surface• Stevens-Johnson: severe EM (mucosa, co
njunctiva, and skin are involved)
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Non-plaque-induced Gingival Lesions
• Gingival manifestation of systemic conditions
b. Allergic reactions (ref.3-2)
- Dental restorative materials
- Toothpaste and mouthwashes
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Characteristics of Chronic Periodontitisref.3-38
• May be prevalent in adults, but can occur in children and adolescents
• Amount of destruction is consistent with the presence of local factors
• Subgingival calculus is a frequent finding
• Associated with a variable microbial pattern
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Characteristics of Chronic Periodontitisref.3-38
• Slow to moderate rate of progression, but may have periods of rapid progression
• Can be further classified on the basis of extent and severity: a. slight or early periodontitis (CAL of 1-2 mm, PPD of 3-4mm), b. moderate periodontitis (CAL up to 4 mm, PPD of 5-7 mm, tooth mobility, moderate bone loss,< than class I furcation involvement), c. severe or advanced periodontitis (CAL>5 mm, usually >/= 7 mm); a. localized (<30% of sites involved), b. generalized (>30% of sites involved).
• Possibly modified by or associated with: systemic diseases (diabetes mellitus, HIV infection), local factors predisposing to periodontitis, environmental factors (cigarette smoking, emotional stress)
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Characteristics of Aggressive Periodontitis
• Prior to age 35• Rapid attachment loss and bone destruction• Familial aggregation?• Subgingival flora:elevated proportions of Actinob
acillus actinomycetemcomitans• Host defense defect (Phagocyte abnormalities)• Hyper-responsive macrophage phenotype, inclu
ding elevated levels of PGE2 and IL-1• Subclassifications: prepubertal (localized: usually not a
ssociated with a systemic disease; generalized: usually accompanied by alteration of PMN functioning), juvenile (LJP, GJP)
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Periodontitis as a Manifestation of Systemic Diseasesref.3-64
Associated with genetic disorders Familial and cyclic neutropenia Down syndrome Leukocyte adhesion deficiency syndrome Papillon-Lefèvre syndrome Chediak-Higashi syndrome Histocytosis syndrome Glycogen storage disease Cohen syndrome Hypophosphatasis Other
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Cyclic Neutropenia
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Cyclic Neutropenia
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Cyclic Neutropenia
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Periodontitis as a Manifestation of Systemic Diseasesref.3-64
• Associated with hematological disorders– Acquired neutropenia– Leukemias– other
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Blood Dyscrasias
• Acute/chronic myeloid leukemia
• Acute/chronic lymphatic leukemia
• Sub- or aleukemic leukemia
• Aplastic anemia
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Hypoplastic Anemia
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Acute Lymphatic Leukemia (AIDS)ref.1-64
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Lymphatic Leukemia
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Down Syndrome
• Poor oral hygiene
• Plaque flora
• Multiple immune dysfunction anatomical/structural dysplasia
• Tissues:– Exaggerated immuno-inflammatory response
with high T4/T8 ratio
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Down Syndromeref.1-104
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Down Syndrome: Post-treatment of Periodontitisref.1-104
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Trisomy 21:Karyotyperef.1-105
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Mongoloid Symptom: Scrotal Tongueref.1-105
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Papillon-Lefèvre syndrome (Hyperkeratosis palmo-plantaris)
• Structural abnormalities
• PMN dysfunctions
• Plaque flora: A.a., Cap. spp.
• Accurate diagnosis– Children with periodontitis
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PLSref.1-106
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PLSref.1-106
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Hyperkeratosis: PLSref.1-107
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Hyperkeratosis: Elbowsref.1-107
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Hyperkeratosis: PLS: Sole Border of Footref.1-107
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Ehlers-Danlos Syndrome
• Type VIII– Type III collagen defect more severe periodon
tal destruction
• Type I– Severe hard tissue dysplasia
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Hypophosphatasia
• Inherited (autosomal recessive trait) deficiency– Alkaline phosphatase
• Defective structure– Bone, cementum, PDL, dentin?/enamel– Early exfoliation: deciduous teeth
• P. gingivalis– Serological evidence
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Necrotizing Ulcerative Gingivitis
• Fusiform-spirochete bacteria flora
• Four zones of NUG: bacterial zone, neutrophil rich zone, necrotic zone, spirochetal infiltration zone
• Constant cultivable flora: P. intermedia, Fusobacterium sp., Treponema, Selenomonas sp.
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NUG
Predisposing Factors* psychological stress
* immunosuppression(HIV-G, HIV-P)
* malnutrition
(protein intake/secondary viral infection: measles)
* other predisposing factors: smoking, pre-existing gingivitis, trauma
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Acute Necrotizing Gingivitis: Homo. With ARC.
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Tooth-Related Issues
• Tooth anatomic factors– cervical enamel projections and enamel
pearls– furcation anatomy and location
• Tooth position
• Root proximity
• Open contact
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Tooth-Related Factors
• Root abnormalities– grooves
• Tooth restorations– restorative marginal discrepancies– effects of restorative materials
• Endodontic considerations
• Tooth fractures
• External root resorption
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Palatogingival Groove
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Enamel Projection: Furcation Involvement
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Enamel Projection
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Enamel Projection: FI3
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Position of Teeth
• Teeth in malocclusion does predispose patients to disease.
• Malocclusion + teeth protrude buccally – Occlusal trauma– Dehiscence– Gingival recession
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Crowding: Plaque Retentionref.2-134
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Iatrogenic Factors Favoring Plaque Accumulation (Restorative
Dentistry)
• Clinically acceptable proximal restoration
• Amalgam restoration with overhang
• Crown margin overhang and open margins
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Overhanging Amalgamref.2-126
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Sanitary Pontic
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Crown Contour
• Respect to periodontitis
• Under contour, over contour
• Over bulky crowns– Plaque stagnation
• Periodontal lesions– Improper crown contours
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Crown Margins
• Four factors: fit, location, smoothness and material
• Place crown margins subgingivally– Periodontal lesions
• Crown placed supragingivally– Tissue health
• Rough margins: hard to keep clean• Zinc phosphate cement
– Irritation and plaque accumulation
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Overhanging Crown Marginsref.2-128
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Over-hanging Restoration
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Poor Restoration
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Pontics, Materials
• Placed under the tissue– Great area of plaque irritation
• Leave a slight clearance– Patient can get under it to clean
• Materials– Glazed porcelain: best tissue response– More important how the prosthesis is
constructed rather than what material it is made of
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Improper Bridge Pontic Form
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Convex Sanitary Pontic Design
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Removable Partial Dentures
• No increased periodontal problems
• Causes abutment teeth to loosen
• The rocking motion of the RPD
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Partial Dentures
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Frenulae, Vestibular Depth and Inadequate Gingiva
• The minimal width of keratinized gingival tissue and gingival health
• Narrow zone of keratinized tissue and frenum pull and/or shallow vestibular depth
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Pocket: High Frenum
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Trauma from occlusion
Glickman’s concept: • 1. zone of irritation: marginal and interdental gingiva– not affected by force of occlusion [transseptal (interdental) and the dentoalveolar collagen bundles]• 2. zone of codestruction: PDL, root cementum, alveolar bone
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Periodontal Inflammation with OTref.5-222 (inflammatory infiltrate spreads directly into the PDL)
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Occlusal Trauma (OT)
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Normal periodontal tissues and OTref.5-225
• 1. normal periodontal tissues exposed to jiggling forces: signs acute inflammation including resorptions of collagen, bone and cementum – PDL space gradually increases • 2. after compensation, PDL shows no sign of inflammation• 3. the supraalveolar connective tissue is not affected by the jiggling forces and no apical down growth of dentogingival epithelium
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Healthy periodontium with reduced height + OT( jiggling forces)ref.5-228
• Alterations occurs in the PDL tissues:
• 1. a widened PDL space
• 2. an increases tooth mobility but do not
lead to further loss of connective
attachmant
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Inflammation + jiggling forcsref.5-230
• 1. pathological and adaptive alterations
occur within the PDL space
• 2. tissue alterations including:
collagen, bone, and cementum
resorptions, widened PDL space and
increased tooth mobility but no further
loss of connective tissue attachment
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Inflammation with infrabony pocket+ jiggling forcesref.5-232
• 1. pathological alterations occur within a zone of the periodontium which is also occupied by inflammatory cell infiltrate• 2. increasing tooth mobility may also associated with an enhanced loss of connective tissue attachment and further downgrowth of dentogingival epithelium
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Pathways of inflammation in periodontitis
• A. interproximally: • 1. from gingiva into the bone• 2. from the bone into the PDL• 3. from the gingiva into the PDL• B. Facially and lingually • 1. from the gingiva along the outer• periosteum• 2. from the periosteum into the bone• 3. from the gingiva into the PDL
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Pathway: Inflammation without OT( inflammatory lesion propagates into the alveolar bone)
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Pathway: Inflammation without OTref.5-222
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Periodontology (2006)
Kaohsiung Medical UniversityCollege of Dental Medicine
Professor Chi-Cheng Tsai, D.D.S., Ph.D.
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Reference• Ref. 1: Color Atlas of Dental Medicine 1, Periodontology, K.H. Rateitschak ed., Thiem
e, 1987.• Ref. 2: Color Atlas of Periodontology, Rateitschak/Wolf/Hassell eds., Thieme,1985.• Ref.3: Annals of Periodontology, volume 4, No. 1, Dec. 1999; 1999 International Work
shop for a Classification of Periodontal Diseases and Conditions.• Ref.4: Advances in Periodontics, Wilson/Kornman/Newman eds., Quintessence Publi
shing Co. Inc., 1992.• Ref. 5: Textbook of Clinical Periodontology, Jan Lindhe ed., Munksgaard,1983.• Ref.6: Textbook of Clinical Periodontology, Jan Lindhe ed., Munksgaard,1997.• Ref.7: Glickman’s Clinical Periodontology, 6th edition, 1984.• Ref. 8: Grant/Stern/Listgarten, Periodontics, 6th edition, Mosby, 1988.• Ref.9: Risk markers for oral diseases, vol. 3, Periodontal diseases, markers of diseas
e susceptibility and activity, N.W. Johnson ed., Cambridge Univ. Press, 1991.