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Pericardial Effusions and Cardiac Tamponade August 2014

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Page 1: Pericardial Effusions and Cardiac Tamponade...Pulsus paradoxus is helpful, but is often non-specific, especially in intermediate volume effusions Diastolic equalization = tamponade

Pericardial Effusions and Cardiac Tamponade

August 2014

Page 2: Pericardial Effusions and Cardiac Tamponade...Pulsus paradoxus is helpful, but is often non-specific, especially in intermediate volume effusions Diastolic equalization = tamponade

What is your comfort level with making the diagnosis of cardiac tamponade in a patient with a pericardial effusion?

A. Low B. Medium C. High

Page 3: Pericardial Effusions and Cardiac Tamponade...Pulsus paradoxus is helpful, but is often non-specific, especially in intermediate volume effusions Diastolic equalization = tamponade

Which part of pericardial effusion/cardiac tamponade evaluation do you find to be most challenging? A. Recognizing pertinent

symptoms B. Recognizing pertinent

physical exam findings C. Reviewing imaging

studies (echo) D. Reviewing

hemodynamics (cath) E. Deciding whether to

perform pericardiocentesis

Page 4: Pericardial Effusions and Cardiac Tamponade...Pulsus paradoxus is helpful, but is often non-specific, especially in intermediate volume effusions Diastolic equalization = tamponade

What is the most sensitive physical exam sign in the diagnosis of cardiac tamponade?

A. Diminished heart sounds

B. Pulsus paradoxus >10 mm Hg

C. Hypotension D. Elevated JVP E. Tachycardia

Page 5: Pericardial Effusions and Cardiac Tamponade...Pulsus paradoxus is helpful, but is often non-specific, especially in intermediate volume effusions Diastolic equalization = tamponade

What is the hemodynamic hallmark of cardiac tamponade when measured in the cath lab?

A. Elevated LVEDP B. Aortic hypotension C. Dip and plateau or

“square root” sign D. Diastolic equalization

of chamber pressures

Page 6: Pericardial Effusions and Cardiac Tamponade...Pulsus paradoxus is helpful, but is often non-specific, especially in intermediate volume effusions Diastolic equalization = tamponade

Which method of pericardiocentesis is preferable in terms of risk/benefits?

A. Subxiphoid B. Parasternal C. Apical D. It depends…

Page 7: Pericardial Effusions and Cardiac Tamponade...Pulsus paradoxus is helpful, but is often non-specific, especially in intermediate volume effusions Diastolic equalization = tamponade

Objectives

Briefly review pericardial structure and function Describe hemodynamic pathophysiology Discuss physical examination data Outline a method to approach echocardiographic

evaluation of effusion Decide between options for therapy in tamponade

Page 8: Pericardial Effusions and Cardiac Tamponade...Pulsus paradoxus is helpful, but is often non-specific, especially in intermediate volume effusions Diastolic equalization = tamponade

Pericardial Anatomy - Layers

Fibrosa Adherent to parietal

serosal layer Not a true sac

Serosa Reflects to form

visceral (epicardium) and parietal pericardium

Page 9: Pericardial Effusions and Cardiac Tamponade...Pulsus paradoxus is helpful, but is often non-specific, especially in intermediate volume effusions Diastolic equalization = tamponade

Pericardial Anatomy - Histology

Serosal layer (both visceral and parietal pericardium) Monocellular layer Lined with

mesothelial cells – microvilli Bear friction,

facilitate fluid/ion exchange Actin filaments Cytoskeletal

filaments

Shabetai R. In: The Pericardium. New York: Grune & Stratton, 1981: 22.

Page 10: Pericardial Effusions and Cardiac Tamponade...Pulsus paradoxus is helpful, but is often non-specific, especially in intermediate volume effusions Diastolic equalization = tamponade

Serosal Layers of the Pericardium

J Am Soc Echocardiogr 2013;26:965-1012.

A. Full thickness parietal pericardium

B. Blood vessels within parietal pericardium

C. Visceral pericardium with microvilli and epicardial adipose

D. Visceral pericardium with thin layer of mesothelial cells separating myocardium

Page 11: Pericardial Effusions and Cardiac Tamponade...Pulsus paradoxus is helpful, but is often non-specific, especially in intermediate volume effusions Diastolic equalization = tamponade

Pericardial Anatomy - Histology

Fibrosal layer Fibrocollagenous

tissue Elastin Approximately 1-

3 mm thick

Spodick DH. In: The Pericardium. New York: Marcel Dekker, 1997: 12.

Page 12: Pericardial Effusions and Cardiac Tamponade...Pulsus paradoxus is helpful, but is often non-specific, especially in intermediate volume effusions Diastolic equalization = tamponade

Pericardial Anatomy – Parietal Sac

J Am Soc Echocardiogr 2013;26:965-1012.

Page 13: Pericardial Effusions and Cardiac Tamponade...Pulsus paradoxus is helpful, but is often non-specific, especially in intermediate volume effusions Diastolic equalization = tamponade

Pericardial Anatomy – Reflections/Sinuses

J Am Soc Echocardiogr 2013;26:965-1012.

Page 14: Pericardial Effusions and Cardiac Tamponade...Pulsus paradoxus is helpful, but is often non-specific, especially in intermediate volume effusions Diastolic equalization = tamponade
Page 15: Pericardial Effusions and Cardiac Tamponade...Pulsus paradoxus is helpful, but is often non-specific, especially in intermediate volume effusions Diastolic equalization = tamponade

Etiologies of Pericardial Effusions

Idiopathic Infectious Viral Bacterial

Inflammatory/CTD Post MI Acute after STEMI Delayed – Dressler’s

Systemic disease Uremia Hypothyroidism

Malignancy Miscellaneous Trauma Surgery Pacemaker placement

Page 16: Pericardial Effusions and Cardiac Tamponade...Pulsus paradoxus is helpful, but is often non-specific, especially in intermediate volume effusions Diastolic equalization = tamponade

Objectives

Briefly review pericardial structure and function Describe hemodynamic pathophysiology Discuss physical examination data Outline a method to approach echocardiographic

evaluation of effusion Decide between options for therapy in tamponade

Page 17: Pericardial Effusions and Cardiac Tamponade...Pulsus paradoxus is helpful, but is often non-specific, especially in intermediate volume effusions Diastolic equalization = tamponade

Cardiac Tamponade Hemodynamics

Intrapericardial

pressures

Atrial pressure

Impedance of venous return

Systemic venous

congestion

Reduced cardiac output

Page 18: Pericardial Effusions and Cardiac Tamponade...Pulsus paradoxus is helpful, but is often non-specific, especially in intermediate volume effusions Diastolic equalization = tamponade

JAMA. 2007;297:1810-1818

Page 19: Pericardial Effusions and Cardiac Tamponade...Pulsus paradoxus is helpful, but is often non-specific, especially in intermediate volume effusions Diastolic equalization = tamponade

JAMA. 2007;297:1810-1818

Normal IVS Interdependence “Pulsus Normalus”

Page 20: Pericardial Effusions and Cardiac Tamponade...Pulsus paradoxus is helpful, but is often non-specific, especially in intermediate volume effusions Diastolic equalization = tamponade

JAMA. 2007;297:1810-1818

Exaggerated IVS Interdependence Pulsus Paradoxus

Page 21: Pericardial Effusions and Cardiac Tamponade...Pulsus paradoxus is helpful, but is often non-specific, especially in intermediate volume effusions Diastolic equalization = tamponade

I feel comfortable assessing for pulsus paradoxus

A. True B. False

Page 22: Pericardial Effusions and Cardiac Tamponade...Pulsus paradoxus is helpful, but is often non-specific, especially in intermediate volume effusions Diastolic equalization = tamponade

Measurement of Pulsus Paradoxus

JAMA. 2007;297:1810-1818

Page 23: Pericardial Effusions and Cardiac Tamponade...Pulsus paradoxus is helpful, but is often non-specific, especially in intermediate volume effusions Diastolic equalization = tamponade

Objectives

Briefly review pericardial structure and function Describe hemodynamic pathophysiology Discuss physical examination data Outline a method to approach echocardiographic

evaluation of effusion Decide between options for therapy in tamponade

Page 24: Pericardial Effusions and Cardiac Tamponade...Pulsus paradoxus is helpful, but is often non-specific, especially in intermediate volume effusions Diastolic equalization = tamponade
Page 25: Pericardial Effusions and Cardiac Tamponade...Pulsus paradoxus is helpful, but is often non-specific, especially in intermediate volume effusions Diastolic equalization = tamponade
Page 26: Pericardial Effusions and Cardiac Tamponade...Pulsus paradoxus is helpful, but is often non-specific, especially in intermediate volume effusions Diastolic equalization = tamponade
Page 27: Pericardial Effusions and Cardiac Tamponade...Pulsus paradoxus is helpful, but is often non-specific, especially in intermediate volume effusions Diastolic equalization = tamponade

Despite its sensitivity, exercise appropriate skepticism of PP

Presence may be masked by:

Hypotension Pericardial adhesions AI ASDs RVH

Can result from other conditions:

COPD CHF MS Massive PE Severe hypovolemic

shock Obesity Tense ascites

Page 28: Pericardial Effusions and Cardiac Tamponade...Pulsus paradoxus is helpful, but is often non-specific, especially in intermediate volume effusions Diastolic equalization = tamponade

Objectives

Briefly review pericardial structure and function Describe hemodynamic pathophysiology Discuss physical examination data Outline a method to approach echocardiographic

evaluation of effusion Decide between options for therapy in tamponade

Page 29: Pericardial Effusions and Cardiac Tamponade...Pulsus paradoxus is helpful, but is often non-specific, especially in intermediate volume effusions Diastolic equalization = tamponade

1. Is There a Pericardial Effusion?

Page 30: Pericardial Effusions and Cardiac Tamponade...Pulsus paradoxus is helpful, but is often non-specific, especially in intermediate volume effusions Diastolic equalization = tamponade

2. How Big is the Effusion?

Parasternal Long Axis

Parasternal Short Axis

Page 31: Pericardial Effusions and Cardiac Tamponade...Pulsus paradoxus is helpful, but is often non-specific, especially in intermediate volume effusions Diastolic equalization = tamponade

2. How Big is the Effusion?

Parasternal Long Axis

Apical 4 Chamber

Page 32: Pericardial Effusions and Cardiac Tamponade...Pulsus paradoxus is helpful, but is often non-specific, especially in intermediate volume effusions Diastolic equalization = tamponade

2. How Big is the Effusion?

Parasternal Long Axis

Parasternal Short Axis

Subcostal 4 Chamber

Page 33: Pericardial Effusions and Cardiac Tamponade...Pulsus paradoxus is helpful, but is often non-specific, especially in intermediate volume effusions Diastolic equalization = tamponade

3. Is it Circumferential? Localized?

Apical 4 Chamber Parasternal Short Axis

Page 34: Pericardial Effusions and Cardiac Tamponade...Pulsus paradoxus is helpful, but is often non-specific, especially in intermediate volume effusions Diastolic equalization = tamponade

4. What Are the Characteristics of the Effusion?

Apical 4 Chamber Parasternal Long Axis

Page 35: Pericardial Effusions and Cardiac Tamponade...Pulsus paradoxus is helpful, but is often non-specific, especially in intermediate volume effusions Diastolic equalization = tamponade

5. How is the Right Heart Doing? Right Atrium

Apical 4 chamber

Page 36: Pericardial Effusions and Cardiac Tamponade...Pulsus paradoxus is helpful, but is often non-specific, especially in intermediate volume effusions Diastolic equalization = tamponade

5. How is the Right Heart Doing? RVOT

M-mode of the Parasternal Long Axis

Page 37: Pericardial Effusions and Cardiac Tamponade...Pulsus paradoxus is helpful, but is often non-specific, especially in intermediate volume effusions Diastolic equalization = tamponade

5. How is the Right Heart Doing? Right Ventricle

M-mode of Parasternal Short Axis

Page 38: Pericardial Effusions and Cardiac Tamponade...Pulsus paradoxus is helpful, but is often non-specific, especially in intermediate volume effusions Diastolic equalization = tamponade

6. Is There Evidence of Venous Congestion?

Subcostal View of IVC

Page 39: Pericardial Effusions and Cardiac Tamponade...Pulsus paradoxus is helpful, but is often non-specific, especially in intermediate volume effusions Diastolic equalization = tamponade

7. What Are the Hemodynamic Consequences of the Effusion?

Pulsed doppler – tricuspid valve inflow varies with respiration by ≥ 25%

Insp Insp Exp Exp

Pulsed doppler – mitral valve inflow varies with respiration

by ≥ 15%

Page 40: Pericardial Effusions and Cardiac Tamponade...Pulsus paradoxus is helpful, but is often non-specific, especially in intermediate volume effusions Diastolic equalization = tamponade

7. What Are the Hemodynamic Consequences of the Effusion?

Insp Insp Exp Exp

Pulsed doppler – pulmonic valve inflow varies with

respiration

Pulsed doppler – aortic valve inflow varies with

respiration

Page 41: Pericardial Effusions and Cardiac Tamponade...Pulsus paradoxus is helpful, but is often non-specific, especially in intermediate volume effusions Diastolic equalization = tamponade

Echo Evaluation of Effusion

1. Is there a pericardial effusion? 2. How big is the effusion? 3. Is it localized? Circumferential? 4. What are the characteristics of the effusion? 5. How is the right heart doing? 6. Is there evidence of venous congestion? 7. What are the hemodynamic consequences of the

effusion?

Page 42: Pericardial Effusions and Cardiac Tamponade...Pulsus paradoxus is helpful, but is often non-specific, especially in intermediate volume effusions Diastolic equalization = tamponade

Objectives

Briefly review pericardial structure and function Describe hemodynamic pathophysiology Discuss physical examination data Outline a method to approach echocardiographic

evaluation of effusion Decide between options for therapy in tamponade

Page 43: Pericardial Effusions and Cardiac Tamponade...Pulsus paradoxus is helpful, but is often non-specific, especially in intermediate volume effusions Diastolic equalization = tamponade
Page 44: Pericardial Effusions and Cardiac Tamponade...Pulsus paradoxus is helpful, but is often non-specific, especially in intermediate volume effusions Diastolic equalization = tamponade

Which type of pericardiocentesis approach have you done the most?

A. Subxiphoid B. Parasternal C. Apical

Page 45: Pericardial Effusions and Cardiac Tamponade...Pulsus paradoxus is helpful, but is often non-specific, especially in intermediate volume effusions Diastolic equalization = tamponade
Page 46: Pericardial Effusions and Cardiac Tamponade...Pulsus paradoxus is helpful, but is often non-specific, especially in intermediate volume effusions Diastolic equalization = tamponade

Approaches to Pericardiocentesis Subxiphoid

Clin Anat. 2012; 25: 872-881c

Page 47: Pericardial Effusions and Cardiac Tamponade...Pulsus paradoxus is helpful, but is often non-specific, especially in intermediate volume effusions Diastolic equalization = tamponade

Clin Anat. 2012; 25: 872-881c

Approaches to Pericardiocentesis Subxiphoid

Page 48: Pericardial Effusions and Cardiac Tamponade...Pulsus paradoxus is helpful, but is often non-specific, especially in intermediate volume effusions Diastolic equalization = tamponade

Approaches to Pericardiocentesis “Echo-Guided” – Parasternal and Apical

Korean Circ J 2012; 42:725-734

Page 49: Pericardial Effusions and Cardiac Tamponade...Pulsus paradoxus is helpful, but is often non-specific, especially in intermediate volume effusions Diastolic equalization = tamponade

Korean Circ J 2012; 42:725-734

Page 50: Pericardial Effusions and Cardiac Tamponade...Pulsus paradoxus is helpful, but is often non-specific, especially in intermediate volume effusions Diastolic equalization = tamponade

Korean Circ J 2012; 42:725-734

Page 51: Pericardial Effusions and Cardiac Tamponade...Pulsus paradoxus is helpful, but is often non-specific, especially in intermediate volume effusions Diastolic equalization = tamponade

Approaches to Pericardiocentesis Risks/Benefits

Technique Pros Cons Subxiphoid Safest approach in emergent

situation Needle in direct contact with

diaphragm, with less risk of injuring the pleura

Highest rates of morbidity and mortality

Irritation to diaphragm and phrenic nerve.

Highest risk of liver injury Possibility of colon or stomach

perforation Parasternal Cardiac notch of left lung leaves

pericardium exposed

Possible higher risk of pneumothorax than with subxiphoid

Internal thoracic vessels lie close to sternal margin

Apical Smaller sized vessels near the

apex L lateral position allows pericardial

fluid to accumulate around the apex

Bare area over apex where pleura usually absent

Piercing wall of left ventricle results in higher rate of ven- tricular fibrillation

Page 52: Pericardial Effusions and Cardiac Tamponade...Pulsus paradoxus is helpful, but is often non-specific, especially in intermediate volume effusions Diastolic equalization = tamponade

Take Home Points

The pericardium is more than just a sac Pulsus paradoxus is helpful, but is often non-

specific, especially in intermediate volume effusions Diastolic equalization = tamponade Cardiac tamponade is a clinical diagnosis Consider the anatomy when planning your

intervention


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