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Innovation · Advancement · Development Performance Simplicity Elegancy The new TProfessional Thermocycler Family

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Innovation · Advancement · Development

PerformanceSimplicity Elegancy

The newTProfessional Thermocycler Family

TProfessional TProfessional BasicBlock High Speed Silver Block Gold anodized 96 well block

Max Heating 5.0 °C/sec* 3 °C/sec

Max Cooling 3.5 °C/sec* 2 °C/sec

Temp Uniformity +/- 0.15 °C within 15 sec at 55 °C+/- 0.25 °C within 15 sec at 70 °C+/- 0.40 °C within 15 sec at 95 °C

+/- 0.20 °C within 15 sec at 55 °C+/- 0.30 °C within 15 sec at 70 °C+/- 0.60 °C within 15 sec at 95 °C

Temp Gradient** 40 °C 26 °C

Temp Range 3 °C to 99 °C 3 °C to 99 °C

Control Accuracy +/- 0.1 °C +/- 0.1 °C

Block Formats 60 well / 96 well / 384 well*** 96 well

Block exchange Within 10 seconds -

Programming modes Spread sheet plus graphical Spread sheet

Software options

Quickstart of the last five programs, program preview prior to start, toggle between spreadsheet and graphical mode, gradient temperature graph,

adjustable ramp rates, extended self test, service files, automatic block recognition, PC control

Quickstart of the last five programs, program preview prior to start, gradient temperature graph, adjustable ramp rates, extended self test, service files, PC control

Display ¼ VGA screen, 320 x 240 pixel

Memory 350 typical programs in up to 30 user directories (optionally password protected)

Auto restart after power failure Yes

Heated Lid High Performance Smart Lid (HPSL)

Lid Temperature Range 30 °C to 99 °C

Power consumption max. 480 Watt

Power Supply 100, 115, 230 Volt / 50-60 Hz

Noise emission Very low

Interface RS232 serial port

Dimensions (WxDxH) 28 cm x 38 cm x 24 cm

Weight 13.0 kg

Order numbers070 -601 TProfessional Basic Gradient 96 well 0.2 ml tubes, plates, strips

070 -701 TProfessional Basic 96 well 0.2 ml tubes, plates, strips

070 -800 TProfessional Gradient 60*** 60 well 0.5 ml tubes

070 -801 TProfessional Gradient 96*** 96 well 0.2 ml tubes, plates, strips

070 -900 TProfessional 60*** 60 well 0.5 ml tubes

070 -901 TProfessional 96*** 96 well 0.2 ml tubes, plates, strips

* Depending on block type ** TProfessional Gradient and TProfessional Basic Gradient *** For alternative block modules see page 3

Te c h n i c a l S p e c i f i c a t i o n a n d O r d e r i n g I n f o r m a t i o n

Innovation · Advancement · Development

P.O.S

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Biometra GmbH Rudolf-Wissell-Str. 30 · D-37079 Göttingen · GermanyTel. +49 551-50686-0 · Fax +49 [email protected] · www.biometra.com · www.tprofessional.com

Design

Lid

TProfessional Design

The elegant TProfessional housing is designed for heavy use. Due to an optimised air stream design even higher efficiency and better temperature uniformity is achieved. The instrument works quietly and consumes little power which in turn leads to low heat emission. The compact footprint saves valuable bench space. Keypad and display have been set to an angle that ensures reflection-free viewing and ergonomic programming.

TProfessional Lid

The TProfessional Lid has been optimised to achieve two essential requirements: prevention of condensation and reliable contact between samples and thermoblock. The lid is powered by Biometra‘s well know smart lid technology which automatically limits lid pressure to save tubes from damage. In addition, the new design of the High Performance Lid ensures an even temperature distribution between samples thus significantly improving temperatureuniformity. With one press on the front button, the lid gently swings open and arrests in its end position.

Innovation · Advancement · Development

T P r o f e s s i o n a l

Gold Anodized96 Well Block

Innovation · Advancement · Development

T P r o f e s s i o n a l B a s i c

Professional Technology for Routine Applications

Gold Anodized 96 Well Block

The TProfessional Basic Thermocycler provides almost all the features of the TProfessional Thermocycler.However, the instrument is available at a budget price, that makes top technology also available for routine applications. The instrument features a gold anodized 96 well block with excellent temperature uniformity. A 96 well Gradient version for quick optimization of new protocols is also available.

The TProfessional Basic provides full functionality of easy spreadsheet programming and quick start of the last five programs.

FeaturesLarge graphical display

Easy spreadsheet programming

Quick start of the last five programs

Gold anodized 96 well block

Gradient or non-gradient version

High performance smart lid

Silent operation

High SpeedSilber Block

T P r o f e s s i o n a l

High Speed Silver Block

To achieve ultimate performance the 96 well and 60 well mo-dules are made of silver. Due to its excellent heat conductivity silver equilibrates extremely quickly, thus providing maximum speed and temperature uniformity. To protect the valuable silver blocks against corrosion, the block surfaces are covered with a thin gold layer.

Top Performance for the Highest Demands

Graphical mode

FeaturesLarge graphical display

Spreadsheet plus graphical programming

Quick start of the last five programs

High speed silver block

Five different block modules

Block exchange in less than 10 seconds

High performance smart lid

Silent operation

Innovation · Advancement · Development

TProfessional exchangeable block modulesOrder number Block format Suitable plastic ware Heating/cooling rate

070 -810 60 well Gradient 0.5 ml tubes 5.0 / 3.5 °C per sec

070 -910 60 well 0.5 ml tubes 5.0 / 3.5 °C per sec

070 -811 96 well Gradient 0.2 ml tubes, plates, strips 5.0 / 3.5 °C per sec

070 -911 96 well 0.2 ml tubes, plates, strips 5.0 / 3.5 °C per sec

070 -912 384 well plates 1.7 / 1.0 °C per sec

... or graphical editing.

In addition to spreadheet programming, the TProfessional allows editing in the graphical mode. Using this option an existing program is quickly modified and can be saved under a new name.

Exchangeable Block Modules

The TProfessional offers five different block modules that can be exchanged in less than 10 seconds. The 96 well and 60 well modules are available with gradient option for quick optimization of new protocols.

UserInterface

www.biometra.comw w w. t p r o f e s s i o n a l . c o m

TProfessional Family

TProfessional User Interface

The TProfessional User Interface incorporates Biometra‘s proven spreadsheet programming philosophy. Avoiding endless serial program windows, all steps of a program are entered in asingle screen. This makes the creation of newor editing existing programs fast and easy. One touch leads from the spreadsheet to an alternative gra phical programmingmode. The TProfessional manages up to 30 individual users (optionally password protected) and features larger memory for increased program capacity.

Innovation · Advancement · Development

Spread sheet mode

The Biometra TProfessional Thermocycler is inspired by the wish to simplify molecular biology research. To reach this goal the instrument housing, lid and block were totally redesigned, providing so far unrealised speed and temperature uniformity. Innovative user software was developed, driven by Biometra‘s 15-year experience in interface design. The result is an easy to use Thermocycler with excellent technical specifications.

Convenient set up of temperature gradients

Gradient steps are defined in a graphical screen, showing the individual temperature for each row. Alternatively, the temperature gradient can be entered directly in the programming spread sheet.

Quick start of the last five programs

The TProfessional displays the five most recently used programs for quick start. Thus, commonly used programs can be started without searching the user directory. The last programs are saved for each user individually.

Easy spreadsheet progamming ...

All program steps are entered in a single screen, thus avoiding endless serial program windows.

I n n o v a t i o n · A d v a n c e m e n t · D e v e l o p m e n t

T3000 Technical Specifi cation / Order information

Order number 050-720 050-723 050-724

T3000 Thermocycler 20 T3000 Thermocycler 48 T3000 Thermocycler combi

Capacity 3 blocks for 20 x 0.5 ml tubes each

3 blocks for 48 x 0.2 ml tubes

or 48 well microplates

or 6 x 8er strips each

3 combi blocks for 18 x

0.5 ml tubes

or 48 x 0.2 ml tubes,

or 48 well microplates

or 6 x 8er strips

Heating rate* 2.1 °C/sec 2.2 °C/sec 1.4 °C/sec

Cooling rate* 1.7 °C/sec 2.0 °C/sec 1.2 °C/sec

Temperature uniformity* +/- 0.5 °C

Temperature range -3 °C to 99.9 °C

Control accuracy +/- 0.1 °C

Blocks Aluminium

Software Program steps are easily entered in a spread sheet

Options: time increment, temperature increment, set ramping rate, direct mode

Program memory 10 individual subdirectories, total capacity of 1.500 program steps

Display High brightness CFL backlight graphical LC Display,viewing area 124 mm x 34 mm, resolution 256 x 64 dots

Auto restart after power failure Yes

Cool samples at 4 °C Yes

Smart lid technology Yes

Lid temperature range 30 °C - 110 °C

Power consumption Max. 380 Watt

Noise emission Very low

Interfaces Serial RS232 port

Dimensions (W x D x H) 30 cm x 38 cm x 19 cm

Weight 11.9 kg

Working conditions 5 °C - 35 °C, 70 % relative humidity

* According to Biometra standard procedure. Technical specifi cations are subject to change.

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Yes

Yes

Yes

30.0 - 99.0 °C

Max. 380 Watt

T 3000 neu 04.04.2006 14:05 Uhr Seite 1

biometrabiomedizinische Analytik GmbHRudolf-Wissell-Straße 30D-37079 GöttingenPhone: + 49 (0) 551/50 686-0Fax: + 49 (0) 551/50 686-66E-mail: [email protected]: www.biometra.com

Three independent Thermocyclers in one instrumentThe T3000 Thermocycler offers three indepen-dent blocks in one housing, thus different pro-tocols can be run at the same time. This makes the T3000 Thermocycler the perfect instrument for laboratories where high fl exibility is needed. With a maximum capacity of 3 x 48 wells the T3000 also offers high throughput in parallel operation. The T3000 Thermocycler is available in three different block versions for 0.2 ml tubes, 0.5 ml tubes or both in the combi block.

Higher speedThe T3000 Thermocycler has been equipped with the latest in Peltier technology. In addi-tion, the heat sink and ventilation system have been completely revised. Thanks to these

features

Three independent Thermocyclers in one housing

Runs three different programs at same time

combi block

Intuitive programming

Context sensitive soft keys

(Smart Lid Technology)

Program storage in individual

Small, strong and hot!

improvements the T3000 achieves faster hea-ting and cooling performance. High ramping rates provide both short experimental times and increased specifi city.

Smart lid technologyLike all Biometra Thermocyclers the T3000 provides heated lids with automatic pressure control. The temperature can be set for each lid individually between 30 °C and 110 °C. The unique design ensures the tubes are not dama-ged in any way by allowing the heated lid to be lowered until the optimum pressure is achieved. This enables close contact between lid and tubes, and reliably prevents excessive pressure.

Like chilli pepper, the new T3000 Thermocycler offers sizzling hot performance in a condensed space.

The T3000 Thermocycler represents the technological upgrade of one of the most successful Thermocyclers in Biometra’s history. Utilising the popular triple block concept, the T3000 has been equipped with the latest in Peltier technology to achieve excellent heating and cooling rates. In addition the software has been completely revised for improved ease of use.

High performance on a small footprint combined with unlimited fl exibility, this is what makes the new T3000 Thermocycler small, strong and very spicy. Sizzling hot performance in every sense!

Easy programmingThe T3000 Thermocycler offers intuitive programming and a new memory structure. New programs are easily created using the spread sheet layout that shows all important parameters on one screen. Four softkeys directly below the display offer quick access to all functions needed in the individual context. For easy retrieval, programs can be stored in individual subdirectories. Software options include both incremental and decremental temperature and time, automatic restart after power failure and extended incubation at sub-ambient temperatures.

Like all Biometra Thermocyclers the T3000provides heated lids with automatic pressurecontrol. The temperature can be set for eachlid individually between 30.0 °C and 99.0 °C.The unique design ensures the tubes are notdamaged in any way by allowing the heatedlid to be lowered until the optimum pressureis achieved. This enables close contact bet-ween lid and tubes, and reliably preventsexcessive pressure.

T 3000 neu 04.04.2006 14:05 Uhr Seite 2

Legal Disclaimer:Purchase of a Biometra Thermocycler conveys a limited non-transferable immunity from suit for the purchaser’s own internal research and development and applied fields other than human in vitro diagnostics under one or more of US Patents Nos. 5,038,852, 5,656,493, 5,333,675, 5,475,610, and 6,703,236, or corresponding claims in their non-US counterparts, owned by Applera Corporation.No right is conveyed expressly, by implication or by estoppel under any patent claim, reagents, kits, or methods such as 5´ nuclease methods, or under any other apparatus or system claim, including but not limited to US PatentNo. 6,814,934 and its non-US counterparts, which describe and claim thermal cyclers capable of real-time detection.Further information on purchasing licenses may be obtained by contacting the Director of Licensing, AppliedBiosystems, 850 Lincoln Centre Drive, Foster City, California 94404, USA.

Three independent Thermocyclers in one instrumentThe T3000 Thermocycler offers three indepen-dent blocks in one housing, thus different pro-tocols can be run at the same time. This makes the T3000 Thermocycler the perfect instrument for laboratories where high fl exibility is needed. With a maximum capacity of 3 x 48 wells the T3000 also offers high throughput in parallel operation. The T3000 Thermocycler is available in three different block versions for 0.2 ml tubes, 0.5 ml tubes or both in the combi block.

Higher speedThe T3000 Thermocycler has been equipped with the latest in Peltier technology. In addi-tion, the heat sink and ventilation system have been completely revised. Thanks to these

features

Three independent Thermocyclers in one housing

Runs three different programs at same time

combi block

Intuitive programming

Context sensitive soft keys

(Smart Lid Technology)

Program storage in individual

Small, strong and hot!

improvements the T3000 achieves faster hea-ting and cooling performance. High ramping rates provide both short experimental times and increased specifi city.

Smart lid technologyLike all Biometra Thermocyclers the T3000 provides heated lids with automatic pressure control. The temperature can be set for each lid individually between 30 °C and 110 °C. The unique design ensures the tubes are not dama-ged in any way by allowing the heated lid to be lowered until the optimum pressure is achieved. This enables close contact between lid and tubes, and reliably prevents excessive pressure.

Like chilli pepper, the new T3000 Thermocycler offers sizzling hot performance in a condensed space.

The T3000 Thermocycler represents the technological upgrade of one of the most successful Thermocyclers in Biometra’s history. Utilising the popular triple block concept, the T3000 has been equipped with the latest in Peltier technology to achieve excellent heating and cooling rates. In addition the software has been completely revised for improved ease of use.

High performance on a small footprint combined with unlimited fl exibility, this is what makes the new T3000 Thermocycler small, strong and very spicy. Sizzling hot performance in every sense!

Easy programmingThe T3000 Thermocycler offers intuitive programming and a new memory structure. New programs are easily created using the spread sheet layout that shows all important parameters on one screen. Four softkeys directly below the display offer quick access to all functions needed in the individual context. For easy retrieval, programs can be stored in individual subdirectories. Software options include both incremental and decremental temperature and time, automatic restart after power failure and extended incubation at sub-ambient temperatures.

Like all Biometra Thermocyclers the T3000provides heated lids with automatic pressurecontrol. The temperature can be set for eachlid individually between 30.0 °C and 99.0 °C.The unique design ensures the tubes are notdamaged in any way by allowing the heatedlid to be lowered until the optimum pressureis achieved. This enables close contact bet-ween lid and tubes, and reliably preventsexcessive pressure.

T 3000 neu 04.04.2006 14:05 Uhr Seite 2

Legal Disclaimer:Purchase of a Biometra Thermocycler conveys a limited non-transferable immunity from suit for the purchaser’s own internal research and development and applied fields other than human in vitro diagnostics under one or more of US Patents Nos. 5,038,852, 5,656,493, 5,333,675, 5,475,610, and 6,703,236, or corresponding claims in their non-US counterparts, owned by Applera Corporation.No right is conveyed expressly, by implication or by estoppel under any patent claim, reagents, kits, or methods such as 5´ nuclease methods, or under any other apparatus or system claim, including but not limited to US PatentNo. 6,814,934 and its non-US counterparts, which describe and claim thermal cyclers capable of real-time detection.Further information on purchasing licenses may be obtained by contacting the Director of Licensing, AppliedBiosystems, 850 Lincoln Centre Drive, Foster City, California 94404, USA.

I n n o v a t i o n · A d v a n c e m e n t · D e v e l o p m e n t

T3000 Technical Specifi cation / Order information

Order number 050-720 050-723 050-724

T3000 Thermocycler 20 T3000 Thermocycler 48 T3000 Thermocycler combi

Capacity 3 blocks for 20 x 0.5 ml tubes each

3 blocks for 48 x 0.2 ml tubes

or 48 well microplates

or 6 x 8er strips each

3 combi blocks for 18 x

0.5 ml tubes

or 48 x 0.2 ml tubes,

or 48 well microplates

or 6 x 8er strips

Heating rate* 2.1 °C/sec 2.2 °C/sec 1.4 °C/sec

Cooling rate* 1.7 °C/sec 2.0 °C/sec 1.2 °C/sec

Temperature uniformity* +/- 0.5 °C

Temperature range -3 °C to 99.9 °C

Control accuracy +/- 0.1 °C

Blocks Aluminium

Software Program steps are easily entered in a spread sheet

Options: time increment, temperature increment, set ramping rate, direct mode

Program memory 10 individual subdirectories, total capacity of 1.500 program steps

Display High brightness CFL backlight graphical LC Display,viewing area 124 mm x 34 mm, resolution 256 x 64 dots

Auto restart after power failure Yes

Cool samples at 4 °C Yes

Smart lid technology Yes

Lid temperature range 30 °C - 110 °C

Power consumption Max. 380 Watt

Noise emission Very low

Interfaces Serial RS232 port

Dimensions (W x D x H) 30 cm x 38 cm x 19 cm

Weight 11.9 kg

Working conditions 5 °C - 35 °C, 70 % relative humidity

* According to Biometra standard procedure. Technical specifi cations are subject to change.

GO

09/

07 5

00-0

54

Yes

Yes

Yes

30.0 - 99.0 °C

Max. 380 Watt

T 3000 neu 04.04.2006 14:05 Uhr Seite 1

biometrabiomedizinische Analytik GmbHRudolf-Wissell-Straße 30D-37079 GöttingenPhone: + 49 (0) 551/50 686-0Fax: + 49 (0) 551/50 686-66E-mail: [email protected]: www.biometra.com