pendine, a dihydropyridine calcium channel blocker (ccb)
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PENDINE, a dihydropyridine calcium channel blocker (CCB)1,2
Effectively lowers mild to moderately elevated blood pressure2
Relieves symptoms of angina pectoris2
Antihypertensive efficacy is similar to other established agents such as b-blockers, diuretics, ACE inhibitors and other CCB (including the dihydropyridines)2
References: 1. Pendine 5 & 10 package insert (August 2006). 2. Haria M, Wagstaff AJ. Amlodipine: A Reappraisal of its Pharmacological Properties and Therapeutic Use in Cardiovascular Disease. Drugs 1995; 50(3):560-586.For full prescribing information refer to the respective package insert approved by the Medicines Regulatory Authority.S3 PENDINE 5 tablets. Each tablet contains amlodipine besylate equivalent to 5 mg amlodipine. Reg. No.: A40/7.1/0057.S3 PENDINE 10 tablets. Each tablet contains amlodipine besylate equivalent to 10 mg amlodipine. Reg. No.: A40/7.1/0058.Applicant: Unichem S.A. (Pty) Ltd., 1st Floor, Pinewood Park, Lonsdale Road, Pinelands, Cape Town 7405.Marketed by: Activo Health (Pty) Ltd. Co. Reg. No.: 2009/009541/07. Block B, Arena Office Park, 272 West Avenue, Centurion, 0157, South Africa.PO Box 11911, Zwartkop, 0051, South Africa. Tel: 0800 (ACTIVO) 228486 | Fax: 086 619 5833 | [email protected] | www.activo.co.za
INDICATIONS:1
Treatment of mild to moderate hypertension, alone or in combination with other antihypertensives.
Treatment of angina pectoris.
DOSAGE AND DIRECTIONS FOR USE:1
Hypertensionand angina
pectoris:Adults:
An initial dose of 5 mg PENDINE once daily is recommended which may be increased to 10 mg once a day after 10 - 14 days of therapy if there is no improvement.
No dose reduction is required when adding PENDINE to thiazide diuretics, beta-blockers, or angiotensin-converting enzyme inhibitors.
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