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Patterns of Inheritance

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Page 1: Patterns of Inheritance. Gregor Mendel “Father” of genetics Mid 1800s Austrian monk Studied math and science in Vienna Taught high school Tended to the

Patterns of Inheritance

Page 2: Patterns of Inheritance. Gregor Mendel “Father” of genetics Mid 1800s Austrian monk Studied math and science in Vienna Taught high school Tended to the

Gregor Mendel“Father” of geneticsMid 1800sAustrian monkStudied math and science in

ViennaTaught high schoolTended to the monastery gardenConducted his genetic studies in

pea plants

Page 3: Patterns of Inheritance. Gregor Mendel “Father” of genetics Mid 1800s Austrian monk Studied math and science in Vienna Taught high school Tended to the

Anatomy of a Flower

Page 4: Patterns of Inheritance. Gregor Mendel “Father” of genetics Mid 1800s Austrian monk Studied math and science in Vienna Taught high school Tended to the

True-breeding StrainsMendel used “self-pollination” to

obtain true breeders

Page 5: Patterns of Inheritance. Gregor Mendel “Father” of genetics Mid 1800s Austrian monk Studied math and science in Vienna Taught high school Tended to the

Cross-Pollination

Page 6: Patterns of Inheritance. Gregor Mendel “Father” of genetics Mid 1800s Austrian monk Studied math and science in Vienna Taught high school Tended to the

Characteristics vs. Traits

CharacteristicPlant height

Pea color

Flower color

Pea shape

Flower position

TraitTall, short

Yellow, green

Purple, white

Wrinkled, smooth

Axial, terminal

Page 7: Patterns of Inheritance. Gregor Mendel “Father” of genetics Mid 1800s Austrian monk Studied math and science in Vienna Taught high school Tended to the
Page 8: Patterns of Inheritance. Gregor Mendel “Father” of genetics Mid 1800s Austrian monk Studied math and science in Vienna Taught high school Tended to the

Mendel’s 4 Hypotheses1. There are alternative versions

of genes that account for variations in characteristics.

Page 9: Patterns of Inheritance. Gregor Mendel “Father” of genetics Mid 1800s Austrian monk Studied math and science in Vienna Taught high school Tended to the

Mendel’s 4 Hypotheses2. For each characteristic, an

organism inherits 2 alleles—one from each parent.

Page 10: Patterns of Inheritance. Gregor Mendel “Father” of genetics Mid 1800s Austrian monk Studied math and science in Vienna Taught high school Tended to the

Mendel’s 4 Hypotheses3. If the 2 alleles of an inherited

pair differ, then one determines the organism’s appearance.

Page 11: Patterns of Inheritance. Gregor Mendel “Father” of genetics Mid 1800s Austrian monk Studied math and science in Vienna Taught high school Tended to the

Mendel’s 4 Hypotheses4. A sperm or egg carries only 1

allele for each characteristic because the 2 alleles segregate (separate) during meiosis.

Law of

Segregatio

n

Page 12: Patterns of Inheritance. Gregor Mendel “Father” of genetics Mid 1800s Austrian monk Studied math and science in Vienna Taught high school Tended to the

Dihybrid Crosses: Mendel’s Law of Independent Assortment

Page 13: Patterns of Inheritance. Gregor Mendel “Father” of genetics Mid 1800s Austrian monk Studied math and science in Vienna Taught high school Tended to the

Dihybrid Crosses: Mendel’s Law of Independent Assortment

X

Page 14: Patterns of Inheritance. Gregor Mendel “Father” of genetics Mid 1800s Austrian monk Studied math and science in Vienna Taught high school Tended to the

In Dihybrid Crosses, Why Don’t We See This….?

Page 15: Patterns of Inheritance. Gregor Mendel “Father” of genetics Mid 1800s Austrian monk Studied math and science in Vienna Taught high school Tended to the

The Rules of Probability

Page 16: Patterns of Inheritance. Gregor Mendel “Father” of genetics Mid 1800s Austrian monk Studied math and science in Vienna Taught high school Tended to the

Traits Thought to be Controlled by a Single Gene

Page 17: Patterns of Inheritance. Gregor Mendel “Father” of genetics Mid 1800s Austrian monk Studied math and science in Vienna Taught high school Tended to the

Family Pedigrees

Page 18: Patterns of Inheritance. Gregor Mendel “Father” of genetics Mid 1800s Austrian monk Studied math and science in Vienna Taught high school Tended to the

Autosomal Recessive Pedigree

Page 19: Patterns of Inheritance. Gregor Mendel “Father” of genetics Mid 1800s Austrian monk Studied math and science in Vienna Taught high school Tended to the

Why We Have Laws Against Marrying Your First Cousin!

Page 20: Patterns of Inheritance. Gregor Mendel “Father” of genetics Mid 1800s Austrian monk Studied math and science in Vienna Taught high school Tended to the

Single-Gene Autosomal Disorders

Page 21: Patterns of Inheritance. Gregor Mendel “Father” of genetics Mid 1800s Austrian monk Studied math and science in Vienna Taught high school Tended to the

WELCOME TO NON-MENDELIAN GENETICS

(WHICH IS MOST OF HUMAN GENETICS!)

Page 22: Patterns of Inheritance. Gregor Mendel “Father” of genetics Mid 1800s Austrian monk Studied math and science in Vienna Taught high school Tended to the

Incomplete Dominance

Page 23: Patterns of Inheritance. Gregor Mendel “Father” of genetics Mid 1800s Austrian monk Studied math and science in Vienna Taught high school Tended to the

Incomplete Dominance

Page 25: Patterns of Inheritance. Gregor Mendel “Father” of genetics Mid 1800s Austrian monk Studied math and science in Vienna Taught high school Tended to the

Codominance: ABO Blood Groups

Page 26: Patterns of Inheritance. Gregor Mendel “Father” of genetics Mid 1800s Austrian monk Studied math and science in Vienna Taught high school Tended to the

Codominance: ABO Blood Groups

Page 27: Patterns of Inheritance. Gregor Mendel “Father” of genetics Mid 1800s Austrian monk Studied math and science in Vienna Taught high school Tended to the

Codominance: ABO Blood Groups

Page 28: Patterns of Inheritance. Gregor Mendel “Father” of genetics Mid 1800s Austrian monk Studied math and science in Vienna Taught high school Tended to the

Why is it so important to give a patient the correct blood type?

Page 29: Patterns of Inheritance. Gregor Mendel “Father” of genetics Mid 1800s Austrian monk Studied math and science in Vienna Taught high school Tended to the

PleiotropyOne gene has the ability to

influence several characteristics

Page 30: Patterns of Inheritance. Gregor Mendel “Father” of genetics Mid 1800s Austrian monk Studied math and science in Vienna Taught high school Tended to the

Polygenic InheritanceThe additive effects of 2 or more

genes on a single phenotypic characteristic.

Page 31: Patterns of Inheritance. Gregor Mendel “Father” of genetics Mid 1800s Austrian monk Studied math and science in Vienna Taught high school Tended to the

Polygenic Inheritance

Page 32: Patterns of Inheritance. Gregor Mendel “Father” of genetics Mid 1800s Austrian monk Studied math and science in Vienna Taught high school Tended to the

Polygenic Inheritance

Page 33: Patterns of Inheritance. Gregor Mendel “Father” of genetics Mid 1800s Austrian monk Studied math and science in Vienna Taught high school Tended to the

Don’t Forget About the Influence of the Environment!

Page 34: Patterns of Inheritance. Gregor Mendel “Father” of genetics Mid 1800s Austrian monk Studied math and science in Vienna Taught high school Tended to the

SEX CHROMOSOMES AND SEX-LINKED GENES

Page 35: Patterns of Inheritance. Gregor Mendel “Father” of genetics Mid 1800s Austrian monk Studied math and science in Vienna Taught high school Tended to the

Sex Determination in Humans

Page 36: Patterns of Inheritance. Gregor Mendel “Father” of genetics Mid 1800s Austrian monk Studied math and science in Vienna Taught high school Tended to the

Sex Determination in Humans

Page 37: Patterns of Inheritance. Gregor Mendel “Father” of genetics Mid 1800s Austrian monk Studied math and science in Vienna Taught high school Tended to the

Red-Green Colorblindness: A Sex-Linked Recessive Trait

Page 38: Patterns of Inheritance. Gregor Mendel “Father” of genetics Mid 1800s Austrian monk Studied math and science in Vienna Taught high school Tended to the

Red-Green Colorblindness: A Sex-Linked Recessive Trait

Page 39: Patterns of Inheritance. Gregor Mendel “Father” of genetics Mid 1800s Austrian monk Studied math and science in Vienna Taught high school Tended to the

Red-Green Colorblindness: A Sex-Linked Recessive Trait

Page 40: Patterns of Inheritance. Gregor Mendel “Father” of genetics Mid 1800s Austrian monk Studied math and science in Vienna Taught high school Tended to the

Hemophilia in the Russian Royal Family

Page 42: Patterns of Inheritance. Gregor Mendel “Father” of genetics Mid 1800s Austrian monk Studied math and science in Vienna Taught high school Tended to the

The Genetics of Calico Cats: Why they are always female!