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LPS Flagellin NF-κB TIRAP MyD88 TLR4 TLR1 TLR2 TLR6 TLR5 TIRAP MyD88 CD14 Nucleus Caspase-1 Activation Caspase-1 (Caspase-5) pro-IL-1β IL-18 (secreted) IL-1β (secreted) pro-IL-18 Inflammasomes NLRP1, NLRP3, NLRP6, NLRC4, RIG-I, AIM2 Asc DNA Sensors RNA poly III DAI MRE11 LRRFIP1 DDX41 IFI16 AIM2 DHX9/36 Toll-like Receptors RIG-I-like Receptors CARD9 Bcl-10 MALT1 NOD-like Receptors Cytosolic DNA Sensors RNA poly III dsDNA (Viral Infection, Bacteria) Inflammatory Response PAMPs / DAMPs IRF3 IRF7 AP1 Inflammation, Immune Regulation, Autophagy, Survival, Proliferation, Apoptosis, Necrosis/Necroptosis Transcription MD2 Bacterial Cell Wall Compounds Lipopeptides Lipoglycans Peptidoglycans STING β-Catenin Type I IFNs Pro-inflammatory Cytokines & Chemokines Cytoplasm RAGE Heparan sulfate HMGB1 TRAM TRIF MyD88 TRIF IRF3 IRF7 NF-κB AP1 RIP1 TRADD MAPK p38 Ras cGAS cGAMP PKR eIF-2α P Protein Synthesis MAVS Bcl-10 CARD9 Mitochondria ER Viral dsRNA ATP + GTP TLR10 MyD88 TLR11 TLR12 Profilin NIK TIRAP MyD88 TRIF MAPK Raf-1 Horseshoe-shaped solenoid N-terminal extracellular leucine-rich repeat (LRR) motifs Compact and globular C-terminal intracellular Toll/interleukin-1 receptor (TIR) domain Activation Translocation TLRs Inhibition TLR11/TLR12: Expressed in mice only ? RIP2 CARD9 Nod2 MDP Nod1 iE-DAP MAPK p38 JNK S100A8/A9 C-type Lectin Receptors Syk Dectin-1 Dectin-2 Mincle Syk FcRγ SAP130 α-Mannose Cord Factor Fungal Hyphae N-linked Mannan DC-SIGN N-linked Mannan Viruses Mycobacteria Zymosan β-Glucan PKCδ RNA Sensors RIG-I MDA5 LGP2 LSm14A Viral RNA Viral Infection + Translocation TLR4 TLR3 TLR7/8 TLR9 Endosome dsRNA ssRNA CpG DNA ODNs CD14 ( ) 4 Pattern Recognition Receptors (PRRs) Signaling Pathways www.adipogen.com Adipogen International Schützenstrasse 12 • CH-4410 Liestal • Switzerland TEL: +41-61-926-60-40 • FAX: +41-61-926-60-49 E-Mail: [email protected] • www.adipogen.com NOV 2013

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Page 1: Pattern Recognition Receptors (PRRs) Signaling Pathways

LPS

Flagellin

NF-κB

TIRAPMyD88

TLR4

TLR1 TLR2 TLR6 TLR5

TIRAPMyD88

CD14

Nucleus

Caspase-1 Activation

Caspase-1(Caspase-5)

pro-IL-1β

IL-18 (secreted)

IL-1β (secreted)

pro-IL-18

InflammasomesNLRP1, NLRP3, NLRP6,

NLRC4, RIG-I, AIM2

Asc

DNA Sensors

RNA poly IIIDAI

MRE11LRRFIP1DDX41IFI16AIM2

DHX9/36

Toll-like Receptors

RIG

-I-lik

e R

ecep

tors

CARD9Bcl-10MALT1

NO

D-li

ke R

ecep

tors

Cyt

osol

ic D

NA

Sens

ors

RNA poly III

dsDNA (Viral Infection,

Bacteria)

Inflammatory Response

PAMPs / DAMPs

IRF3IRF7

AP1

Inflammation, Immune Regulation, Autophagy, Survival, Proliferation, Apoptosis, Necrosis/Necroptosis

Transcription

MD2

Bacterial Cell Wall Compounds

Lipopeptides LipoglycansPeptidoglycans

STING

β-Catenin

Type I IFNsPro-inflammatory Cytokines & Chemokines

Cytoplasm

RAGEHeparansulfate

HMGB1

TRAMTRIF

MyD88 TRIF

IRF3 IRF7NF-κBAP1

RIP1

TRADD

MAPKp38

Ras

cGAS

cGAMPPKR

eIF-2αP

Protein Synthesis

MAVSBcl-10CARD9

MitochondriaER

Viral dsRNA

ATP +

GTP

TLR10

MyD88

TLR11TLR12

Profilin

NIK

TIRAPMyD88

TRIF

MAPK

Raf-1

Horseshoe-shaped solenoid N-terminal extracellular leucine-rich repeat (LRR) motifs

Compact and globular C-terminal intracellular Toll/interleukin-1 receptor (TIR) domain

ActivationTranslocation TLRs

Inhibition

TLR11/TLR12: Expressed in mice only

?

RIP2CARD9

Nod2MDP

Nod1iE-D

AP

MAPKp38JNK

S100A8/A9C-type Lectin Receptors

Syk

Dectin-1 Dectin-2 Mincle

Syk

FcRγ

SAP130α-MannoseCord Factor

Fungal HyphaeN-linked Mannan

DC-SIGN

N-linked MannanViruses

MycobacteriaZymosanβ-Glucan

PKCδ

RNA Sensors

RIG-IMDA5LGP2

LSm14A

Viral RNA

Viral Infection

+

Tran

sloc

atio

n

TLR4

TLR3TLR7/8 TLR9

EndosomedsRNAssRNA

CpG DNAODNs

CD14

( )4

Pattern Recognition Receptors (PRRs) Signaling Pathways

www.adipogen.com

Adipogen InternationalSchützenstrasse 12 • CH-4410 Liestal • Switzerland TEL: +41-61-926-60-40 • FAX: +41-61-926-60-49E-Mail: [email protected] • www.adipogen.com

NO

V 20

13

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