patient-derived xenograft (pdx) tumor...
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Patient-Derived Xenograft (PDX) Tumor Models
• One of thelargestcollectionofAsiaprevalent tumortypesintheworld» Liver-284» Lung-196» Colorectal-105» Gastric-93» Esophageal-90» Cholangiocarinoma-41
• DrugresistantPDX• Recurrent/metastasisPDX
• 400PDXsin-lifeforrapidstudyonset• End-userfriendlydatabase• Effectiveprojectmanagement• AAALACaccreditedSPFfacility
• Clinicalinformation» Clinicalclassification» Pathology» Treatmenthistory
• PDXgrowthcharacteristics» Growthcurves» SoCtreatment
• >500PDXgenomicprofiled» Affymetrixmicroarray» Whole-exomesequencing» SNP6.0array» RNAseq
> 1000 PDX Panel
Unique Com
positi
on
Quality Service
Well Annotated
The largest collection of Asia prevalent tumor types with genomic profiling
Clinical diagnosis ProfiledPancreatic cancer 54 57
Kidney cancer 8 9Head & Neck cancer 14 27
Breast cancer 16 17Melanoma 11 14
Liposarcoma 3 10GIST 7 13
Nasopharyngeal carcinoma 2 4Ovarian cancer 1 2
Gallbladder cancer 7 9Glioma 4 4
Lymphoma 19 20Endometrial cancer 4 4
• > 1000 PDX models• The largest collection of Asia prevalent PDX models• > 500 PDX models with genetic profiling• Searchable online database with mobile APP
Clinical diagnosis Profiled Established
Lung cancerNSCLC
ACD 34 38
SCC 108 117
Large cell 3 3
SCLC 4 4
Others 20 34
Gastric cancer 77 93
HCC 139 284
Colorectal cancer (105) 105 7
Esophageal cancer 63 90
Cholangiocarcinoma 36 41
Oncology & Immunology
Cervical cancer 2 4 Sarcoma 1 2
Established
CH CO ES GIST HCC LP LC ME PanC GC Total AMP 1 2 1 9 6 1 16 36ERBB2 2 1 9 12FGFR1 4 4FGFR2 1 1KIT 1 1KRAS 1 6 7MET 1 8 1 1 11Fusion 6 6ALK 4 4FGFR2 1 1ROS1 1 1Mutation 2 62 3 3 5 1 31 8 48 13 176AKT1 1 1BRAF 3 1 3 1 8EGFR 1 4 1 6ERBB2 1 1FGFR3 1 4 5HRAS 1 1JAK1 1 1KIT 3 4 7KRAS 2 41 2 12 42 9 108NRAS 1 1 2PIK3CA* 14 3 1 1 10 4 3 36Total 3 64 4 3 14 1 43 8 49 29 218
PDX with oncogene amplification, mutation & Fusions
NOTE: 1) Gene amplification was defined as average CNV>5 from SNP6.0 array data2) Only reported oncogenic/hotspot mutations were counted . PIK3CA mutation usually co-occur with other events (KRAS mutation et al.)
Integrated online database for PDX, CDX & Syngeneic tumor models with mobile App
http://onco.wuxiapptec.com
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Oncology & Immunology