XI. Pathophysiology

Bite of Aedes Aegypti

Virus penetration to skin

Virus infects and replicate inside the Langerhans cell (immunity of the skin)

Langerhans cell release interferon (to limit the spread of infection)

Infected Langerhans cells go to the lymphatic (alert the immune system)

Then goes to the circulation

Results in viremia (high level of virus in bloodstream)

Activation of immune response Lymphocytes

Neutrophils and White blood cells

Release of pyrogen

Reset of hypothalamus

FEVER Increase blood pressure in vessel

Modifiable

• Environment uncovered

stock water

Non- Modifiable

• Gender

11RASH