Cysts

Pathology Lab

Amin Abusallamh

Dentigerous cyst

1. Stratified squamous epithelium with goblet & mucous cells .2. C.T. conatining numerous fibroblasts & collagen fibers

stratified squamous epithelium

Cystic cavity

B M

C T

goblet

Keratocyst:

- stratified squamous epithelium .- corregated epithelial lining .- polarized basal cell with tomb stone pattern .

stratified squamous epithelium

Cystic cavity fill with keratin

Junction between epith. And CT is flat

Calcifying Epithelial Odontogenic Cyst

- tall columnar epithelium .- hyperchromatic nucleous away from the basal cells .- stellate reticulum containig ameloblastic-like cells between the inner and outer enamel epithelium ,

Cyst cavity

tall columnar epithelium

CT

B M

keratinized epithelium (ghost cell)

stratified squamous epithelium

Radicular cyst:

- thick stratified squamous epithelium because of chronic inflammation .- C.T containing lymphocytes + inflammatory cells .- characteristis feature is >>> eosinophilic bodies ( rashtom's )

Cyst cavity

stratified squamous epithelium

Basement membrane C.T containing lymphocytes + inflammatory cells

eosinophilic bodies

Aneurysmal bone cyst

- pseudocyst .- neumerous blood sinusoids with RBCs .- multinucleated giant cells in C.T. stroma .- reactive osteoid tissue .

Cyst cavity

reactive osteoid tissue

giant cells

RBC

Mucocele (Mucous extravasation Phenomenon

- mucous secretion located in the center .- it has a granulation tissue .- numerous minro salivary glands .

mucous secretion

granulation tissue

minro salivary glands

Odontogenic tumors

Ameloblastoma

Picture 1 : Follicular ameloblastoma .- epithelial follicles in C.T stroma .

- in the follicle : * pripheral columnar cells ( ameloblast like cells ) .* central cells ( stellate reticulum like cells ) .

Picture 2 : Plyxiform ameloblastoma .- pripheral tall columnar cells ( ameloblast like cells ) .- central cells ( stellate reticulum like cells ) .- C.T. stroma in between .

C.T

central cells

pripheral columnar

follicle epithelium

Adenomatoid Odontogenic Tumors (AOT)

-sheets of polyhidral odontogenic epithelium .

-- duct like structures lined by one or two layers of columnar cells ( ameloblast like cells ) with band of eosinophilic material in between .

Cannulated tubule Tall columnar

Basal cell

Cementoifying fibroma

-mesenchymal odontogenic tumor ,

-fibrous proliferating delicate C.T. ( fibers + fibroblasts ) scattered with numerous calcification which either cementum or bone trabeculae .

cementum or bone trabeculae

Cementoblastoma

-proliferating cementume-like structures .

--masses of cementum formed by cementoblasts in priphery with fibroblast in the center .

cementume

Fibrous stroma

Ameloblastic Fibroma

rosets/islands of epithelial tissue in proliferating neoplastic delicated fibrous C.T .- in the priphery : columnar cells ( ameloblast-like cells ) .- in the center : stellate reticulum-like cells .

islands of epithelial

C.T

columnar cells

stellate reticulum-like cells

Bone Diseases

Osteogenesis Imperfecta (OI)

1. Replacing of bone with irregular ammature woven bone 2. Incearse number of oteocyte and osteoblast3. Osteoid non mineralization

Osteoid non mineralization

woven bone

Incearse number of oteocyte and osteoblast

Osteopetrosis

1. dense thick bone trabeculae with numerous inactive multinucleated osteoclast

2. Decease the bone marrow and its fiber

multinucleated osteoclast

Cherubism

1. Replacing of bone by fibrous tissue2. (Highly fibroblast + blood vessels + collagen fiber + multinucleated giant

cells + ossteoed tissue)

multinucleated giant ossteoed tissue)blood vessels

fibrous tissue

Fibrous dysplasia of bone (FD

1. Thin slender irregular bone trabeculae in fibrous tissue stroma take the shape of Chinese letter.

2. Replacing of bone with fibrous tissue.

Thin slender irregular bone trabeculae

fibrous tissue

Brown node of hyperparathyroidism

Replacing of bone with highly cellular connective tissue with numerous multinucleated giant cell + BV + pigment hemosiderin

hemosiderin

BV

giant cell

connective tissue

Paget’s disease of bone

1. High dense thick irregular bone trabeculae with numerous multinucleated giant cell + BV + prominent reversal line + prominent osteoblast and osteoclast

2. The marrow has been replaced by fibrous tissue

reversal line

prominent osteoblast and osteoclast

giant cell

Chronic focal sclerosing osteomyelitis

1. thick irregular bone trabeculae with multinucleated giant cell + BV + reversal line + empty lacuna of death osteocyte

2. Fibrotic Bone marrow with chronic inflammatory cells

chronic inflammatory cells

giant cell

BV

empty lacuna of death osteocyte

reversal line