pathological calcification
TRANSCRIPT
Deposition of calcium salts in tissues
Calcium is usually deposited as calcium phosphate & calcium carbonate
May occur in the form Hydroxyapatite similar to that of normal bone
Is the decomposition of calcium salts in dead or degenerated tissue (injured tissues)
Seen in areas of necrosis, large arteries & damaged heart valves
Often visible to the naked eye & ranges from gritty sand like grains to firm rock hard material
Trauma
Parasitic or T.B infections
Prolonged immobility can give rise to blood clots, which can eventually calcify
Metastatic calcification can occur in normal tissues whenever there is Hypercalcemia
High calcium levels in the blood and all tissues due to systematic mineral imbalance
Any disorder that increases the serum calcium level can lead to calcification in inappropriate locations
Increased secretion of parathyroid hormone
Destruction of bone tissue as in tumors of bone marrow
Vitamin D intoxication
Renal failure