patheon dosage capabilities
DESCRIPTION
Patheon Operational CapabilitiesTRANSCRIPT
For more information on our services or products, contact your Patheon Representative or email us at [email protected]
Solid and SterileFinished Dose Forms
All the Choices and Expertise You Need to Succeed
Solid Dose Forms – Specialized and Conventional With the experience of thousands of projects, Patheon provides access to a wide range of conventional solid dose form as well as specialized combinations and controlled-release technologies. All solid dose form choices are carried out with the expansive scientific resources and expertise to build high-quality formulations for even the most complex drug products.
Softgels Bolstered by the acquisition of Banner Pharmacaps, Patheon is your new highly capable ally in the development and manufacture of softgel products. We give you access to a host of patent-protected specialized technologies to meet the specific needs of your molecules and markets. This includes advanced solutions for enhancing solubility and bioavailability, as well as unique controlled-release and oral delivery technologies.
Sterile Products Patheon offers extensive sterile product development and manufacturing capabilities in Europe and North America, including world-class expertise in lyophilization and ready-to-use dose formats. We have developed more than 100 large molecules for customers that include eight of the top ten biotech companies. Because the challenges you face are ones we’ve likely overcome before, you can be confident of your success. That plus our exceptional regulatory track record, Right First Time and On-Time performance, and three consecutive years of European Outsourcing Awards.
Develop and Launch Products Anywhere in the World
Published 9/14 PATH0340R1
Americas Europe
Cincinnati USA
High Point USA
Greenville USA
Toronto Canada
Whitby Canada
Manati Puerto Rico
Mexico City Mexico
Bourgoin France
Monza Italy
Ferentino Italy
Milton Park UK
Swindon UK
Tilburg Netherlands
Solid Dose Forms
Spec
ializ
ed
Trilayer Tablets l l l l lMicrotablets l l
Beads in Capsules l l lCoated Beads l l l
Tablets in Capsules l l lFast Dispersible Tablets l l l l l
Laser-Drilled Controled-Release Tablets l l l l l lLiquid-Filled Capsules l
Biphasic Liquid-Filled Capsules l l lBilayer Chewable Tablets l l
Beads in Liquid-Filled Capsules l l l lHydrophilic Gel Matrix l
Polymer Matrix l l l l l l lWax Matrix l l l
Pulsatile Release l l lPolymer Coating l l l l
Sublingual Tablets l l l l l
Con
vent
iona
l Uncoated l l l l l l l lCoated l l l l l l l l
Powder-Filled Capsules l l l l l l l lPowders and Granules l l l l l l l l
Coated Beads l l lMultiparticulates l l l
Softg
els
Softgel Capsules l l lTwist-Off Softgels l l l
EnteriCare® Enteric Softgels l l lLiquiSoft™ Chewable Liquid-Filled Softgels l l l
Versatrol™ Controlled-Release Softgels l lSolvatrol™ Enhanced Solubility Softgels l l
Soflet® Gelcaps l lChewels® Chewable Gels l l
Sterile Products
Vials l l l lLyophilized Vials l l l l
Prefilled Syringes lCartridges l
US HeadquartersPatheon Inc. 4721 Emperor Blvd, Suite 200 Durham, NC 27703-8580 USA P: +1 919 226 3200 F: +1 919 474 2269 www.patheon.com
European Headquarters Patheon UK Ltd. Kingfisher Drive Covingham, Swindon Wiltshire SN3 5BZ UK P: +44 1793 524411 F: +44 1793 487053 www.patheon.com
Japan Office Patheon K.K. 7F Wakamatsu Building, 3-3-6 Nihonbashi Hon-cho, Chuo-ku, Tokyo 103-0023 Japan P: +81 3 6202 7666 F: +81 3 6202 7676 www.patheon.com/home-japan.aspx
Liquid-Filled Vials— Aseptic filling, terminal sterilization when required— Solutions, suspensions or emulsions— Extensive range of sizes and stopper/cap combinations— Clear or amber glass vials
Lyophilized Vials— World-class scientific and technical expertise— Wide selection of vial sizes, including ISO standard— Small- and large-scale manufacturing
Prefilled Syringes— Broad range of sizes and configurations with handles— Glass or polymeric — Fill range from 0.1 ml to 20 ml
Cartridges — Range of cartridge configurations— Glass or plastic
Bilayer Tablets 2 IRs or IR+CR/SR fixed-dose combination
Trilayer Tablets 3 IRs or IR+placebo+CR/SR fixed-dose combination
Microtablets IR or CR/SR; low-dose tablets; via device, capsule or sachet
Tablets in Capsules IR or CR/SR, over-encapsulation for blinded clinical supply
Chewable Tablets IR or CR/SR single or bilayer fixed-dose combinations; ideal for pediatrics and high-dose compounds
Fast Dispersible Tablets IR, disintegrates/disperses as suspension in water, divisible into 4 parts for titration, ideal for pediatrics
Sublingual Tablets IR, single layer tablets for sublingual administration.
Beads in Hard-Shell Capsules IRs and/or CRs/SRs fixed-dose combination, uncoated or polymer coated; extrusion, spheronization or drug layering
Beads in Liquid-Filled Capsules IRs and/or CRs/SRs fixed-dose combination, hard shell, coated beads in liquid vehicle
Liquid-Filled Capsules IR or CR/SR; hard shell; options to improve solubility, bioavailability and absorption; ideal for Phase I and beyond
Biphasic Liquid-Filled Capsules IR or CR/SR; hard shell; biohasic vehicle to improve solubility, bioavailability and absorption; ideal for Phase I and beyond
Laser-Drilled Controlled-Release Tablets
CR/SR; hard shell; osmotic, zero-order, controlled-release over a defined time period
Hydrophilic Gel Matrix Controlled-release technology
Polymer Matrix Controlled-release technology
Wax Matrix Controlled-release technology
Pulsatile Release Controlled-release technology
Polymer Coating Controlled-release technology
Tablets IR or CR/SR, single-layer tablets, coated or uncoated, with or without break line or embossing, range of shapes and sizes
Powder-Filled Capsules IR, two-piece gelatin or HPMC capsules in a range of sizes and multiple color combinations
Powders, Granules, Coated Beads Multiparticulates
IR, bottles and sachets, packaged in bottles and sachets of varying dimensions and fill weights
Softgel Capsules— Immediate-release soft gelatin capsules— Clinical development scale production— 13.7B capsule commercial manufacturing capacity— Extensive range of sizes, colors and imprinting options
Twist-Off Softgels— Precise unit dosing for oral liquid and topical products— Hermetic seal helps preserve API— Portable convenience improves patient compliance— Consistent dosing for reliable results in clinical trials
EnteriCare® Enteric Softgels— Enteric properties are integrated into the gelatin shell— Eliminates risk of reflux and gastric irritation— Protects acid-labile compounds— Compatible with SMEDDS, hydrophilic and viscous fills
Versatrol™ Controlled-Release Softgels
— Unique matrix system to fine-tune release— Controlled-release capabilities integrated into fill— Lipophilic and hydrophilic formulations— Suitable for compounds with low solubility
Solvatrol™ Enhanced Solubility Softgels
— Enhances the solubility and bioavailability — Lipophilic and hydrophilic formulations— Provides a stable solvent delivery system— Reduces plasma level variability
LiquiSoft™ Chewable Liquid-Filled Softgels
— Solid dose for oral liquid formulations— Soft, chewable shell with a pleasant burst of liquid Enhances
performance of poorly soluble compounds— Flavors and aromas mask unpleasant tastes and odors
Soflet® Gelcaps— Patented technology enrobes tablets— Traditional gelatin or non-animal gelatin— Safely encases highly potent compounds— Perfect for clinical trial blinding
Chewels® Chewable Gels— Chewable for patient comfort and convenience— Rapid onset of action and relief of symptoms— Pursue pediatric and geriatric markets— Patented technology
Conventional Solid Dose Forms
Specialized Solid Dose Forms Softgels
Liqu
id-F
illed
Via
l
Sterile Doses Commercial DevelopmentVial Size* (ml) Stopper Size (mm) Greenville, USA Monza, Italy Ferentino, Italy Ferentino, Italy Greenville, USA
2 13 l l l l l4 13 l l5 20 l l6 20 l l7 20 l8 20 l l
10 20 l l l l l12 20 l13 1315 20 l20 20/13 l l l l l25 20 l l30 20 l l l l50 20/32 l l60 28 l
100 20/28/32 l200 28/32 l250 32 l300 28 l500 28/32 l
Lyop
hiliz
ed V
ial
2 13/20 l l l l l3 13 l4 13 l5 13/20 l l l l l6 20 l l l l7 20 l8 20 l l l
10 20 l l l l l12 20 l l15 20 l17 20 l20 20 l l l l l25 20 l l30 20 l l50 20 l l
100 20 l
Capsules Required Container Size (cc) by Fill Count
Size Fill Volume Range (CC) 60 Count 100 Count 250 Count 500 Count
Ova
l
2 0.089-0.111 60 60 75 150
3 0.182-0.228 60 75 120 200
4 0.209-0.261 60 100 150 250
5 0.312-0.389 75 100 150 300
6 0.318-0.397 75 100 150 400
7.5 0.386-0.482 75 100 225 400
9 0.469-0.586 100 120 300 600
10 0.567-0.709 100 120 300 600
Obl
ong
3 0.181-0.227 75 75 200 350
4 0.243-0.304 100 120 250 400
5 0.285-0.356 100 120 300 750
6 0.338-0.422 100 120 400 750
8 0.452-0.564 120 200 500 950
14 0.863-1.079 200 300 750 1250
16 0.975-1.218 250 400 950 1500
Rou
nd
2 0.073-0.123 60 60 75 150
3 0.138-0.183 60 75 120 200
4 0.173-0.244 60 100 150 250
5 0.195-0.305 75 100 150 300
6 0.279-0.367 75 100 150 400
7 0.305-0.428 75 100 225 400
15 0.737-0.922 150 225 500 750
Vial SizeMonza, Italy Ferentino, Italy Greenville, USA
Sterile Area 1
Sterile Area 2
Sterile Area 3
Sterile Area 1
Sterile Area 2 Sterile
Area 2Development Sterile Unit
Line 1 Line 2 Line 3Cytotoxic CTM
External OD (mm)
Example Fill2 Twin Lyo
Units2 Twin Lyo
Units2 Twin Lyo
UnitsLyo Unit 1 Lyo Unit 2 3 Lyo Units 3 Lyo Units 3 Lyo Units
16 2, 4 138,000 111,000 127,000 120,000 153,000 37,000 24,000 490,000 318,000 329,000 43,000 8,600
21 5 81,000 65,000 74,000 69,000 89,000 19,000 14,000 295,000 200,000 206,000 27,000 5,400
22 6 73,000 58,000 67,000 67,000 86,000 18,000 12,500 265,000 179,000 185,000 24,000 4,800
24 10, 15 61,000 49,000 55,000 55,000 69,000 14,000 10,000 174,000 117,000 121,000 16,000 3,200
30 20, 25, 30 37,000 30,000 35,000 35,000 45,000 9,500 6,400 142,000 95,000 98,000 13,000 2,600
42 15 17,000 13,000 15,000 17,000 22,000 4,700 3,500 65,000 42,000 44,000 5,000 1,000
Lyo Batch Sizes for the Most Readily Available Vial Sizes
* ISO standard and non-standard vials can be accommodated.
Sterile Products
Softgels Shapes and Sizes
Other shapes and sizes available. Formulation can effect options.
Liquid-Filled Vials— Aseptic filling, terminal sterilization when required— Solutions, suspensions or emulsions— Extensive range of sizes and stopper/cap combinations— Clear or amber glass vials
Lyophilized Vials— World-class scientific and technical expertise— Wide selection of vial sizes, including ISO standard— Small- and large-scale manufacturing
Prefilled Syringes— Broad range of sizes and configurations with handles— Glass or polymeric — Fill range from 0.1 ml to 20 ml
Cartridges — Range of cartridge configurations— Glass or plastic
Bilayer Tablets 2 IRs or IR+CR/SR fixed-dose combination
Trilayer Tablets 3 IRs or IR+placebo+CR/SR fixed-dose combination
Microtablets IR or CR/SR; low-dose tablets; via device, capsule or sachet
Tablets in Capsules IR or CR/SR, over-encapsulation for blinded clinical supply
Chewable Tablets IR or CR/SR single or bilayer fixed-dose combinations; ideal for pediatrics and high-dose compounds
Fast Dispersible Tablets IR, disintegrates/disperses as suspension in water, divisible into 4 parts for titration, ideal for pediatrics
Sublingual Tablets IR, single layer tablets for sublingual administration.
Beads in Hard-Shell Capsules IRs and/or CRs/SRs fixed-dose combination, uncoated or polymer coated; extrusion, spheronization or drug layering
Beads in Liquid-Filled Capsules IRs and/or CRs/SRs fixed-dose combination, hard shell, coated beads in liquid vehicle
Liquid-Filled Capsules IR or CR/SR; hard shell; options to improve solubility, bioavailability and absorption; ideal for Phase I and beyond
Biphasic Liquid-Filled Capsules IR or CR/SR; hard shell; biohasic vehicle to improve solubility, bioavailability and absorption; ideal for Phase I and beyond
Laser-Drilled Controlled-Release Tablets
CR/SR; hard shell; osmotic, zero-order, controlled-release over a defined time period
Hydrophilic Gel Matrix Controlled-release technology
Polymer Matrix Controlled-release technology
Wax Matrix Controlled-release technology
Pulsatile Release Controlled-release technology
Polymer Coating Controlled-release technology
Tablets IR or CR/SR, single-layer tablets, coated or uncoated, with or without break line or embossing, range of shapes and sizes
Powder-Filled Capsules IR, two-piece gelatin or HPMC capsules in a range of sizes and multiple color combinations
Powders, Granules, Coated Beads Multiparticulates
IR, bottles and sachets, packaged in bottles and sachets of varying dimensions and fill weights
Softgel Capsules— Immediate-release soft gelatin capsules— Clinical development scale production— 13.7B capsule commercial manufacturing capacity— Extensive range of sizes, colors and imprinting options
Twist-Off Softgels— Precise unit dosing for oral liquid and topical products— Hermetic seal helps preserve API— Portable convenience improves patient compliance— Consistent dosing for reliable results in clinical trials
EnteriCare® Enteric Softgels— Enteric properties are integrated into the gelatin shell— Eliminates risk of reflux and gastric irritation— Protects acid-labile compounds— Compatible with SMEDDS, hydrophilic and viscous fills
Versatrol™ Controlled-Release Softgels
— Unique matrix system to fine-tune release— Controlled-release capabilities integrated into fill— Lipophilic and hydrophilic formulations— Suitable for compounds with low solubility
Solvatrol™ Enhanced Solubility Softgels
— Enhances the solubility and bioavailability — Lipophilic and hydrophilic formulations— Provides a stable solvent delivery system— Reduces plasma level variability
LiquiSoft™ Chewable Liquid-Filled Softgels
— Solid dose for oral liquid formulations— Soft, chewable shell with a pleasant burst of liquid Enhances
performance of poorly soluble compounds— Flavors and aromas mask unpleasant tastes and odors
Soflet® Gelcaps— Patented technology enrobes tablets— Traditional gelatin or non-animal gelatin— Safely encases highly potent compounds— Perfect for clinical trial blinding
Chewels® Chewable Gels— Chewable for patient comfort and convenience— Rapid onset of action and relief of symptoms— Pursue pediatric and geriatric markets— Patented technology
Conventional Solid Dose Forms
Specialized Solid Dose Forms Softgels
Liqu
id-F
illed
Via
l
Sterile Doses Commercial DevelopmentVial Size* (ml) Stopper Size (mm) Greenville, USA Monza, Italy Ferentino, Italy Ferentino, Italy Greenville, USA
2 13 l l l l l4 13 l l5 20 l l6 20 l l7 20 l8 20 l l
10 20 l l l l l12 20 l13 1315 20 l20 20/13 l l l l l25 20 l l30 20 l l l l50 20/32 l l60 28 l
100 20/28/32 l200 28/32 l250 32 l300 28 l500 28/32 l
Lyop
hiliz
ed V
ial
2 13/20 l l l l l3 13 l4 13 l5 13/20 l l l l l6 20 l l l l7 20 l8 20 l l l
10 20 l l l l l12 20 l l15 20 l17 20 l20 20 l l l l l25 20 l l30 20 l l50 20 l l
100 20 l
Capsules Required Container Size (cc) by Fill Count
Size Fill Volume Range (CC) 60 Count 100 Count 250 Count 500 Count
Ova
l
2 0.089-0.111 60 60 75 150
3 0.182-0.228 60 75 120 200
4 0.209-0.261 60 100 150 250
5 0.312-0.389 75 100 150 300
6 0.318-0.397 75 100 150 400
7.5 0.386-0.482 75 100 225 400
9 0.469-0.586 100 120 300 600
10 0.567-0.709 100 120 300 600
Obl
ong
3 0.181-0.227 75 75 200 350
4 0.243-0.304 100 120 250 400
5 0.285-0.356 100 120 300 750
6 0.338-0.422 100 120 400 750
8 0.452-0.564 120 200 500 950
14 0.863-1.079 200 300 750 1250
16 0.975-1.218 250 400 950 1500
Rou
nd
2 0.073-0.123 60 60 75 150
3 0.138-0.183 60 75 120 200
4 0.173-0.244 60 100 150 250
5 0.195-0.305 75 100 150 300
6 0.279-0.367 75 100 150 400
7 0.305-0.428 75 100 225 400
15 0.737-0.922 150 225 500 750
Vial SizeMonza, Italy Ferentino, Italy Greenville, USA
Sterile Area 1
Sterile Area 2
Sterile Area 3
Sterile Area 1
Sterile Area 2 Sterile
Area 2Development Sterile Unit
Line 1 Line 2 Line 3Cytotoxic CTM
External OD (mm)
Example Fill2 Twin Lyo
Units2 Twin Lyo
Units2 Twin Lyo
UnitsLyo Unit 1 Lyo Unit 2 3 Lyo Units 3 Lyo Units 3 Lyo Units
16 2, 4 138,000 111,000 127,000 120,000 153,000 37,000 24,000 490,000 318,000 329,000 43,000 8,600
21 5 81,000 65,000 74,000 69,000 89,000 19,000 14,000 295,000 200,000 206,000 27,000 5,400
22 6 73,000 58,000 67,000 67,000 86,000 18,000 12,500 265,000 179,000 185,000 24,000 4,800
24 10, 15 61,000 49,000 55,000 55,000 69,000 14,000 10,000 174,000 117,000 121,000 16,000 3,200
30 20, 25, 30 37,000 30,000 35,000 35,000 45,000 9,500 6,400 142,000 95,000 98,000 13,000 2,600
42 15 17,000 13,000 15,000 17,000 22,000 4,700 3,500 65,000 42,000 44,000 5,000 1,000
Lyo Batch Sizes for the Most Readily Available Vial Sizes
* ISO standard and non-standard vials can be accommodated.
Sterile Products
Softgels Shapes and Sizes
Other shapes and sizes available. Formulation can effect options.
Liquid-Filled Vials— Aseptic filling, terminal sterilization when required— Solutions, suspensions or emulsions— Extensive range of sizes and stopper/cap combinations— Clear or amber glass vials
Lyophilized Vials— World-class scientific and technical expertise— Wide selection of vial sizes, including ISO standard— Small- and large-scale manufacturing
Prefilled Syringes— Broad range of sizes and configurations with handles— Glass or polymeric — Fill range from 0.1 ml to 20 ml
Cartridges — Range of cartridge configurations— Glass or plastic
Bilayer Tablets 2 IRs or IR+CR/SR fixed-dose combination
Trilayer Tablets 3 IRs or IR+placebo+CR/SR fixed-dose combination
Microtablets IR or CR/SR; low-dose tablets; via device, capsule or sachet
Tablets in Capsules IR or CR/SR, over-encapsulation for blinded clinical supply
Chewable Tablets IR or CR/SR single or bilayer fixed-dose combinations; ideal for pediatrics and high-dose compounds
Fast Dispersible Tablets IR, disintegrates/disperses as suspension in water, divisible into 4 parts for titration, ideal for pediatrics
Sublingual Tablets IR, single layer tablets for sublingual administration.
Beads in Hard-Shell Capsules IRs and/or CRs/SRs fixed-dose combination, uncoated or polymer coated; extrusion, spheronization or drug layering
Beads in Liquid-Filled Capsules IRs and/or CRs/SRs fixed-dose combination, hard shell, coated beads in liquid vehicle
Liquid-Filled Capsules IR or CR/SR; hard shell; options to improve solubility, bioavailability and absorption; ideal for Phase I and beyond
Biphasic Liquid-Filled Capsules IR or CR/SR; hard shell; biohasic vehicle to improve solubility, bioavailability and absorption; ideal for Phase I and beyond
Laser-Drilled Controlled-Release Tablets
CR/SR; hard shell; osmotic, zero-order, controlled-release over a defined time period
Hydrophilic Gel Matrix Controlled-release technology
Polymer Matrix Controlled-release technology
Wax Matrix Controlled-release technology
Pulsatile Release Controlled-release technology
Polymer Coating Controlled-release technology
Tablets IR or CR/SR, single-layer tablets, coated or uncoated, with or without break line or embossing, range of shapes and sizes
Powder-Filled Capsules IR, two-piece gelatin or HPMC capsules in a range of sizes and multiple color combinations
Powders, Granules, Coated Beads Multiparticulates
IR, bottles and sachets, packaged in bottles and sachets of varying dimensions and fill weights
Softgel Capsules— Immediate-release soft gelatin capsules— Clinical development scale production— 13.7B capsule commercial manufacturing capacity— Extensive range of sizes, colors and imprinting options
Twist-Off Softgels— Precise unit dosing for oral liquid and topical products— Hermetic seal helps preserve API— Portable convenience improves patient compliance— Consistent dosing for reliable results in clinical trials
EnteriCare® Enteric Softgels— Enteric properties are integrated into the gelatin shell— Eliminates risk of reflux and gastric irritation— Protects acid-labile compounds— Compatible with SMEDDS, hydrophilic and viscous fills
Versatrol™ Controlled-Release Softgels
— Unique matrix system to fine-tune release— Controlled-release capabilities integrated into fill— Lipophilic and hydrophilic formulations— Suitable for compounds with low solubility
Solvatrol™ Enhanced Solubility Softgels
— Enhances the solubility and bioavailability — Lipophilic and hydrophilic formulations— Provides a stable solvent delivery system— Reduces plasma level variability
LiquiSoft™ Chewable Liquid-Filled Softgels
— Solid dose for oral liquid formulations— Soft, chewable shell with a pleasant burst of liquid Enhances
performance of poorly soluble compounds— Flavors and aromas mask unpleasant tastes and odors
Soflet® Gelcaps— Patented technology enrobes tablets— Traditional gelatin or non-animal gelatin— Safely encases highly potent compounds— Perfect for clinical trial blinding
Chewels® Chewable Gels— Chewable for patient comfort and convenience— Rapid onset of action and relief of symptoms— Pursue pediatric and geriatric markets— Patented technology
Conventional Solid Dose Forms
Specialized Solid Dose Forms SoftgelsLi
quid
-Fill
ed V
ial
Sterile Doses Commercial DevelopmentVial Size* (ml) Stopper Size (mm) Greenville, USA Monza, Italy Ferentino, Italy Ferentino, Italy Greenville, USA
2 13 l l l l l4 13 l l5 20 l l6 20 l l7 20 l8 20 l l
10 20 l l l l l12 20 l13 1315 20 l20 20/13 l l l l l25 20 l l30 20 l l l l50 20/32 l l60 28 l
100 20/28/32 l200 28/32 l250 32 l300 28 l500 28/32 l
Lyop
hiliz
ed V
ial
2 13/20 l l l l l3 13 l4 13 l5 13/20 l l l l l6 20 l l l l7 20 l8 20 l l l
10 20 l l l l l12 20 l l15 20 l17 20 l20 20 l l l l l25 20 l l30 20 l l50 20 l l
100 20 l
Capsules Required Container Size (cc) by Fill Count
Size Fill Volume Range (CC) 60 Count 100 Count 250 Count 500 Count
Ova
l
2 0.089-0.111 60 60 75 150
3 0.182-0.228 60 75 120 200
4 0.209-0.261 60 100 150 250
5 0.312-0.389 75 100 150 300
6 0.318-0.397 75 100 150 400
7.5 0.386-0.482 75 100 225 400
9 0.469-0.586 100 120 300 600
10 0.567-0.709 100 120 300 600
Obl
ong
3 0.181-0.227 75 75 200 350
4 0.243-0.304 100 120 250 400
5 0.285-0.356 100 120 300 750
6 0.338-0.422 100 120 400 750
8 0.452-0.564 120 200 500 950
14 0.863-1.079 200 300 750 1250
16 0.975-1.218 250 400 950 1500
Rou
nd
2 0.073-0.123 60 60 75 150
3 0.138-0.183 60 75 120 200
4 0.173-0.244 60 100 150 250
5 0.195-0.305 75 100 150 300
6 0.279-0.367 75 100 150 400
7 0.305-0.428 75 100 225 400
15 0.737-0.922 150 225 500 750
Vial SizeMonza, Italy Ferentino, Italy Greenville, USA
Sterile Area 1
Sterile Area 2
Sterile Area 3
Sterile Area 1
Sterile Area 2 Sterile
Area 2Development Sterile Unit
Line 1 Line 2 Line 3Cytotoxic CTM
External OD (mm)
Example Fill2 Twin Lyo
Units2 Twin Lyo
Units2 Twin Lyo
UnitsLyo Unit 1 Lyo Unit 2 3 Lyo Units 3 Lyo Units 3 Lyo Units
16 2, 4 138,000 111,000 127,000 120,000 153,000 37,000 24,000 490,000 318,000 329,000 43,000 8,600
21 5 81,000 65,000 74,000 69,000 89,000 19,000 14,000 295,000 200,000 206,000 27,000 5,400
22 6 73,000 58,000 67,000 67,000 86,000 18,000 12,500 265,000 179,000 185,000 24,000 4,800
24 10, 15 61,000 49,000 55,000 55,000 69,000 14,000 10,000 174,000 117,000 121,000 16,000 3,200
30 20, 25, 30 37,000 30,000 35,000 35,000 45,000 9,500 6,400 142,000 95,000 98,000 13,000 2,600
42 15 17,000 13,000 15,000 17,000 22,000 4,700 3,500 65,000 42,000 44,000 5,000 1,000
Lyo Batch Sizes for the Most Readily Available Vial Sizes
* ISO standard and non-standard vials can be accommodated.
Sterile Products
Softgels Shapes and Sizes
Other shapes and sizes available. Formulation can effect options.
For more information on our services or products, contact your Patheon Representative or email us at [email protected]
Solid and SterileFinished Dose Forms
All the Choices and Expertise You Need to Succeed
Solid Dose Forms – Specialized and Conventional With the experience of thousands of projects, Patheon provides access to a wide range of conventional solid dose form as well as specialized combinations and controlled-release technologies. All solid dose form choices are carried out with the expansive scientific resources and expertise to build high-quality formulations for even the most complex drug products.
Softgels Bolstered by the acquisition of Banner Pharmacaps, Patheon is your new highly capable ally in the development and manufacture of softgel products. We give you access to a host of patent-protected specialized technologies to meet the specific needs of your molecules and markets. This includes advanced solutions for enhancing solubility and bioavailability, as well as unique controlled-release and oral delivery technologies.
Sterile Products Patheon offers extensive sterile product development and manufacturing capabilities in Europe and North America, including world-class expertise in lyophilization and ready-to-use dose formats. We have developed more than 100 large molecules for customers that include eight of the top ten biotech companies. Because the challenges you face are ones we’ve likely overcome before, you can be confident of your success. That plus our exceptional regulatory track record, Right First Time and On-Time performance, and three consecutive years of European Outsourcing Awards.
Develop and Launch Products Anywhere in the World
Published 9/14 PATH0340R1
Americas Europe
Cincinnati USA
High Point USA
Greenville USA
Toronto Canada
Whitby Canada
Manati Puerto Rico
Mexico City Mexico
Bourgoin France
Monza Italy
Ferentino Italy
Milton Park UK
Swindon UK
Tilburg Netherlands
Solid Dose Forms
Spec
ializ
ed
Trilayer Tablets l l l l lMicrotablets l l
Beads in Capsules l l lCoated Beads l l l
Tablets in Capsules l l lFast Dispersible Tablets l l l l l
Laser-Drilled Controled-Release Tablets l l l l l lLiquid-Filled Capsules l
Biphasic Liquid-Filled Capsules l l lBilayer Chewable Tablets l l
Beads in Liquid-Filled Capsules l l l lHydrophilic Gel Matrix l
Polymer Matrix l l l l l l lWax Matrix l l l
Pulsatile Release l l lPolymer Coating l l l l
Sublingual Tablets l l l l l
Con
vent
iona
l Uncoated l l l l l l l lCoated l l l l l l l l
Powder-Filled Capsules l l l l l l l lPowders and Granules l l l l l l l l
Coated Beads l l lMultiparticulates l l l
Softg
els
Softgel Capsules l l lTwist-Off Softgels l l l
EnteriCare® Enteric Softgels l l lLiquiSoft™ Chewable Liquid-Filled Softgels l l l
Versatrol™ Controlled-Release Softgels l lSolvatrol™ Enhanced Solubility Softgels l l
Soflet® Gelcaps l lChewels® Chewable Gels l l
Sterile Products
Vials l l l lLyophilized Vials l l l l
Prefilled Syringes lCartridges l
US HeadquartersPatheon Inc. 4721 Emperor Blvd, Suite 200 Durham, NC 27703-8580 USA P: +1 919 226 3200 F: +1 919 474 2269 www.patheon.com
European Headquarters Patheon UK Ltd. Kingfisher Drive Covingham, Swindon Wiltshire SN3 5BZ UK P: +44 1793 524411 F: +44 1793 487053 www.patheon.com
Japan Office Patheon K.K. 7F Wakamatsu Building, 3-3-6 Nihonbashi Hon-cho, Chuo-ku, Tokyo 103-0023 Japan P: +81 3 6202 7666 F: +81 3 6202 7676 www.patheon.com/home-japan.aspx
For more information on our services or products, contact your Patheon Representative or email us at [email protected]
Solid and SterileFinished Dose Forms
All the Choices and Expertise You Need to Succeed
Solid Dose Forms – Specialized and Conventional With the experience of thousands of projects, Patheon provides access to a wide range of conventional solid dose form as well as specialized combinations and controlled-release technologies. All solid dose form choices are carried out with the expansive scientific resources and expertise to build high-quality formulations for even the most complex drug products.
Softgels Bolstered by the acquisition of Banner Pharmacaps, Patheon is your new highly capable ally in the development and manufacture of softgel products. We give you access to a host of patent-protected specialized technologies to meet the specific needs of your molecules and markets. This includes advanced solutions for enhancing solubility and bioavailability, as well as unique controlled-release and oral delivery technologies.
Sterile Products Patheon offers extensive sterile product development and manufacturing capabilities in Europe and North America, including world-class expertise in lyophilization and ready-to-use dose formats. We have developed more than 100 large molecules for customers that include eight of the top ten biotech companies. Because the challenges you face are ones we’ve likely overcome before, you can be confident of your success. That plus our exceptional regulatory track record, Right First Time and On-Time performance, and three consecutive years of European Outsourcing Awards.
Develop and Launch Products Anywhere in the World
Published 9/14 PATH0340R1
Americas Europe
Cincinnati USA
High Point USA
Greenville USA
Toronto Canada
Whitby Canada
Manati Puerto Rico
Mexico City Mexico
Bourgoin France
Monza Italy
Ferentino Italy
Milton Park UK
Swindon UK
Tilburg Netherlands
Solid Dose Forms
Spec
ializ
ed
Trilayer Tablets l l l l lMicrotablets l l
Beads in Capsules l l lCoated Beads l l l
Tablets in Capsules l l lFast Dispersible Tablets l l l l l
Laser-Drilled Controled-Release Tablets l l l l l lLiquid-Filled Capsules l
Biphasic Liquid-Filled Capsules l l lBilayer Chewable Tablets l l
Beads in Liquid-Filled Capsules l l l lHydrophilic Gel Matrix l
Polymer Matrix l l l l l l lWax Matrix l l l
Pulsatile Release l l lPolymer Coating l l l l
Sublingual Tablets l l l l l
Con
vent
iona
l Uncoated l l l l l l l lCoated l l l l l l l l
Powder-Filled Capsules l l l l l l l lPowders and Granules l l l l l l l l
Coated Beads l l lMultiparticulates l l l
Softg
els
Softgel Capsules l l lTwist-Off Softgels l l l
EnteriCare® Enteric Softgels l l lLiquiSoft™ Chewable Liquid-Filled Softgels l l l
Versatrol™ Controlled-Release Softgels l lSolvatrol™ Enhanced Solubility Softgels l l
Soflet® Gelcaps l lChewels® Chewable Gels l l
Sterile Products
Vials l l l lLyophilized Vials l l l l
Prefilled Syringes lCartridges l
US HeadquartersPatheon Inc. 4721 Emperor Blvd, Suite 200 Durham, NC 27703-8580 USA P: +1 919 226 3200 F: +1 919 474 2269 www.patheon.com
European Headquarters Patheon UK Ltd. Kingfisher Drive Covingham, Swindon Wiltshire SN3 5BZ UK P: +44 1793 524411 F: +44 1793 487053 www.patheon.com
Japan Office Patheon K.K. 7F Wakamatsu Building, 3-3-6 Nihonbashi Hon-cho, Chuo-ku, Tokyo 103-0023 Japan P: +81 3 6202 7666 F: +81 3 6202 7676 www.patheon.com/home-japan.aspx