partnering to identify a new public health threat: evali...partnering to identify a new public...
TRANSCRIPT
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Partnering to Identify a New Public Health Threat: EVALI
WCLN Webinar 1/22/20
Dr. Ian PrayCenters for Disease Control and PreventionWisconsin Department of Health ServicesEpidemic Intelligence Service
Noel StantonWisconsin State Laboratory of HygieneChemical Response [email protected]
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Vaping-Associated Lung
Injury
Wisconsin, 2019
Ian Pray, PhD MPH
Epidemic Intelligence Service
Centers for Disease Control and Prevention
Wisconsin Department of Health Services
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1 in 5 high school students reports vapingin past 30 days*
Vaping
*2018, CDC
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Use in past 30 days among 12th graders*
Vaping
*National adolescent drug trends, NEJM
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Use in past 30 days among 12th graders*
Vaping
*National adolescent drug trends, NEJM
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Vaping
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Marijuana
30% of youth who vape report vaping marijuana products1
7% of college student vape non-nicotine products2
1JAMA Pediatrics, 20182Kenna et al, 2017
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Marijuana
Legal in 33 states (11 recreational)
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THC Cartridges
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THC Cartridges
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• Five teenagers hospitalized with severe respiratory illnesses
• 2 of 5 in ICU with severe respiratory failure requiring mechanical ventilation
• All reported recent vaping
July 10 – Children's Hospital of Wisconsin
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• Young and otherwise healthy (16-17 years old)
• Symptoms: Shortness of breath, fever, weakness, nausea, vomiting for 3-6 days prior to admission
• On admission: Hypoxic, acute respiratory distress, abnormal chest x-ray and CT scans
July 10 – Children's Hospital of Wisconsin
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July 10 – Children's Hospital of Wisconsin
• Diffuse bilateral infiltrates
• “Ground-glass” opacities
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July 10 – Children's Hospital of Wisconsin
• Extensive negative work-up for possible causes
– Respiratory viruses
– Bacterial (Legionella, M. pneumoniae, S. pneumoniae)
– Fungal infections
– Neoplasm, cardiac, rheumatoid
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Initial Investigation
1. Develop a case definition Vaping in past 3 months
Infiltrates on chest imaging
Rule out other possible causes
2. Determine the extent of the outbreak Memo to clinicians to report cases Develop reporting criteria Alert local public health
3. Interview cases to find common exposure
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Timeline
7/10: Initial report
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Timeline
7/25: Memo to providers
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Timeline
7/31: Illinois reports first case
8/2: Alert CDC
8/2: Press release: “we strongly urge people to avoid vaping”
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Timeline
8/7: My first day of work!
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Timeline
8/7: My first day of work!
8/8: National alert (“Epi-X”)
8/8: Press release #2: “patients have reported a variety of substances including nicotine and THC, and we don’t yet know the cause”
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Timeline
8/20: Receive field support from CDC
8/23: First death reported in IL resident
8/25: CDC: 215 cases reported from 25 states
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Timeline
8/29: 32 confirmed cases in Wisconsin
8/29: Press release #3:
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Timeline
9/6: NEJM: Case series of first 53 cases from IL and WI
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Timeline
9/11: Massive drug bust in Kenosha, WI
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Timeline
9/11: 380 cases in 36 states
9/16: 505 cases in 38 states
9/24: 805 cases in 46 states, 12 deaths
9/17: CDC activates emergency operation center
CDC Recommends: Don’t use any e-cigarette, or vaping, products. Cause of outbreak still unknown.
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Timeline
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Results
86 patient interviews complete
79% male
Median age: 21 years old(15-53)
87% used THC cartridges
89% of cartridges purchased from “informal sources”
66% used Dank Vapes
13% used only nicotine
CDC Recommends: Don’t use any e-cigarette, or vaping, products, particularly those containing THC.Cause of the outbreak still unknown.
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Timeline
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Timeline10/8: 1,299 cases in 49 states
10/22: 1,604 cases in 49 states, 26 deaths• 86% used THC cartridges• 11% used only nicotine
CDC Recommends: Don’t use any e-cigarette, or vaping, products, particularly those containing THC.Cause of the outbreak still unknown.
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Timeline
October: states start received product testing results from FDA
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Timeline
November: CDC releases results from BAL fluid testing
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Finding the cause: Laboratory
evidence
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So Where is WSLH in the EVALI RESPONSE?
Finding the cause: Laboratory evidence
WISCONSIN STATE LABORATORY OF HYGIENE - UNIVERSITY OF WISCONSIN
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WSLH Activities• Initial screening of BAL
specimens
• QTOF testing
• Analytical Library focused on drugs, pesticides
• Early findings of THC metabolites, treatment drugs, pthalates
• Pthalates likely an artifact of plastics used for BAL
• Drugs included steroids, antibiotics, benzos, anti-nausea drugs
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WSLH Activities• FACILITATION
• Worked closely with WDPH to coordinate
• Submissions from LPH, LE, clinical labs, and pathologists
• Provided proper collection, packaging, and shipment information
• Directed samples to FDA, CDC (two branches)
• Assisted with result interpretation
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Vaping in WI• Samples received:
• ~170 vaping pods, devices, cartridges
• One package edibles, two dabs
• One white grape flavored white owl cigar
• Many examples of packaging
• 12 BAL specimens
• Many more not retained
• 8 FFPE blocks
• 2 frozen lung tissue samples
• 1 hunk of brain tissue
• 1 each blood, plasma, sputum, nasal swab
• 2 LIMS, a BIG spreadsheet, DHS Redcap database
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WISCONSIN STATE LABORATORY OF HYGIENE - UNIVERSITY OF WISCONSIN
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Vitamin E Acetate Testing• Developed and verified method (GCMS)
• 22 tested, quantified
• Additional 30 pending
• Qualitative, due to limited sample volume
• None detected in nicotine-based products
• None detected in 2018 products
• Detected in 2019 products
• Concentration range 25.6-37.2% w/v
• Nationally, range~2-82%
• Consistent with national observations
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Finding the cause: Laboratory
evidenceFDA Product Analysis
810 vaping products analyzed
51% of THC products (n=501) contained vitamin E acetate
~20-60% VEA by volume
77% of cases had product with vitamin E acetate
No significant levels of other toxicants, pesticides, metals, etc in THC or nicotine-containing products
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Finding the cause: Laboratory
evidence
?
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Finding the cause: Laboratory
evidence
100% (29 of 29) of case-associated BAL fluids contained Vitamin E acetate
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Finding the cause: Laboratory
evidence
Vitamin E acetate• Added as diluent to THC oils in late 2018*
*Leafly.com - https://www.leafly.com/news/health/toxic-vaping-vapi-evali-lung-injury-rise-and-fall-of-vitamin-e-oil-honey-cut
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Finding the cause: Laboratory
evidence
*Leafly.com - https://www.leafly.com/news/health/toxic-vaping-vapi-evali-lung-injury-rise-and-fall-of-vitamin-e-oil-honey-cut
ED visits, nationwide
Vitamin E acetate• Added as diluent to THC oils in late 2018*
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Finding the cause: Laboratory
evidence
Law enforcement seizures (WI / MN*)
• 2019: VEA detected • 2018: VEA not detected
ED visits, nationwide
*MMWR: https://www.cdc.gov/mmwr/volumes/68/wr/mm6847e1.htm?s_cid=mm6847e1_w
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Winding down...Wisconsin
As of 1/22:
104 confirmed or probable cases
No deaths
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Winding down...
In the U.S.
As of 1/22:
2,668 cases
60 deaths CDC Recommends (12/13/2019): -The specific cause of EVALI is unknown-VEA has been detected, but more than one compound could be causing EVALI-Continue to refrain from use of all e-cigarette or vaping products
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Winding down...
UPDATE – January 17th, 2020-Do not use THC-containing vaping products-Do not add VEA to vaping products
In the U.S.
As of 1/22:
2,668 cases
60 deaths
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Role of clinical labs
Detection of vitamin E acetate in BAL fluid was the key to solving the outbreak
Identify case-associated samples
Retain samples
Ship to WSLH
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Challenges for clinical labs
Short retention time for clinical specimens (~7 days for BAL)
Communication between clinical team and lab
EVALI was not standardized with a test or “flag”
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Continuing work...
Animal studies to understand pathophysiology of VEA inhalation
What about the 10% of cases reporting only nicotine use?
Pathology studies to understand mechanism of lung injury
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Continuing work...
Marijuana legalization
Flavor ban
Tobacco 21
FDA testing
Harm reduction
Lots of questions about policy and regulation of vaping industry...
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Acknowledgements
Wisconsin Department of Health ServicesWisconsin State Lab of HygieneU.S. Centers for Disease Control and PreventionU.S. Food and Drug AdministrationChildren’s Hospital of Wisconsin
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LRN-C – The Laboratory Response Network for Chemical Events
• Chemical Threat Response
• Responder support, unknown substances
• Clinical testing for exposure to WMD &
threat agents
• E.g. nerve agents, vesicants, CN, metals,
volatiles, amanitin, ricin & abrin, others
• Labs classified by level
• WSLH is a level 1 response lab
• CDC surge capacity lab
• ASAP testing of 1000 patients
• Development of tests to address
chemical exposures, e.g.
brodifacoum
WISCONSIN STATE LABORATORY OF HYGIENE - UNIVERSITY OF WISCONSIN
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Thanks!
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Novel Coronavirus (2019-nCoV) from Wuhan China
• 2019 – nCoV is a newly emerging respiratory virus with >300 new infections and 6 deaths. Cases have been identified in 5 countries, including the US.
• If you have a suspect patient, contact our State Epidemiologists at the Division of Public Health (DPH) for information, testing approval, and for a PUI form. Tom Haupt or Anna Kocharian
608-267-9003 main line608-258-0099 after hours
• Testing is available at the CDC.Check their website for the most
up to date guidance.Samples for testing must:
Have DPH approval Have PUI formBe sent through WSLH
• If you have questions about how to submit samples for testing, contact WSLH Customer Service.1-800-862-1013