ORAL AND MAXILLOFACIAL PATHOLOGY OOOO

e130 Abstracts February 2014

AO-49 - OSTEOSARCOMAS: CLINICOPATHOLOGICALCHARACTERISTICS OF FIVE CASES WITH EMPHASISON DIAGNOSTIC FEATURES. ÁGUIDA MARIAMENEZES AGUIAR MIRANDA, FÁBIO RAMÔA PIRES,JULIANA DE NORONHA SANTOS NETTO, SIMONEMACEDO AMARAL. UNIVERSIDADE ESTÁCIO DE SÁ EUNIVERSIDADE DO ESTADO DO RIO DE JANEIRO.

Osteosarcomas are aggressive malignancies that can affectgnathic bones. Successful management depends on early diagnosisand adequate treatment. The aim of this report is to show clini-copathological and diagnostic features from five gnathic osteosar-comas. Three maxillary (woman, 63; woman, 49; man, 37) and twomandibular (woman, 49; man, 45) osteosarcomas were included. Inall five cases there was swelling of the affected area; three werepainful. All cases demonstrated ill-defined radiological images, andthree had irregular widening of the periodontal ligament. Histo-logical diagnosis revealed chondroblastic osteosarcoma in threecases and osteoblastic osteosarcoma in two. Adequate interpreta-tion of clinical signs and symptoms and correct diagnosis areessential for the prompt treatment of gnathic osteosarcomas.

AO-50 - PAPILLARY THYROID CARCINOMA ANDPARATHYROID ADENOMA IN PATIENT WITH ORALLESIONS OF BROWN TUMOR OF HYPERPARATHY-ROIDISM: A MULTIDISCIPLINARY APPROACH. THAÍSBORGUEZAN NUNES, SHEYLA BATISTA BOLOGNA,TATHYANE HARUMI NAKAJIMA TESHIMA, ANDRÉALUSVARGHI WITZEL, MARCELLO MENTA SIMONSENNICO, SILVIA VANESSA LOURENÇO. DEPARTMENT OFSTOMATOLOGY, SCHOOL OF DENTISTRY, USP ANDCLINICS HOSPITAL, SCHOOL OF MEDICINE, USP.

The brown tumor of hyperparathyroidism is a metabolic dis-order that affects the skeleton but is rarely found in the mandible.Woman, 37, came to the CDO-FOUSP complaining of oral pain.Examination showed swelling in the neck and bleeding intraorallesions. The patient had cachexia and was referred to HCFMUSPfor investigation and management. Incisional biopsy of the orallesion was performed, with histopathological results supporting adiagnosis of central giant cell lesion. Blood tests showed highlevels of parathyroid hormone (PTH). Computed tomographyrevealed the presence of lytic lesions in bones and a solid-cysticlesion near the thyroid, which was surgically removed. In this case,the evaluation of the oral lesions allowed clinicians to diagnosebrown tumor of hyperparathyroidism, parathyroid adenoma, andpapillary thyroid carcinoma. Surgical removal of the cause andnormalization of the patient’s metabolism are fundamental toachieving regression of the oral lesions.

AO-51 - PAROTID LARGE CELL ANAPLASTIC LYM-PHOMA ALK NEGATIVE: CASE REPORT. ANDRELEONARDO DE CASTRO COSTA, MARCUS ANTONIO DEMELLO BORBA, RYUICHI HOSHI, EDVAN DE QUEIROZCRUSOE, EDUARDO MOREIRA DE QUEIROGA, CARLOSEDUARDO BACCHI. ESCOLA BAHIANA DE MEDICINA ESAUDE PUBLICA/ HOSPITAL PORTUGUES.

Lymphoma of the salivary gland accounts for 5% of cases ofextranodal lymphoma and 10% of malignant salivary gland tu-mors. Most primary salivary gland lymphomas are B marginalzone lymphomas arising on a background of sialadenitis associ-ated with autoimmune disorders such as Sjogren’s syndrome.Primary T cell lymphoma of the salivary gland is rare. A previ-ously healthy teenage girl had a case of right parotid progressive

swelling. After an inconclusive fine needle aspiration (FNA) bi-opsy and rapid growth of the lesion involving the skin, she wasunderwent a superficial parotidectomy. Final histology resultsrevealed large cell anaplastic lymphoma ALK negative. Afterthis, computed tomography�positron electron tomography (CT-PET) scan showed no other site of disease and the patient wasstaged as IE. She underwent successive chemotherapy, radio-therapy, and bone marrow transplantation. After 2 years of followup she still alive with no evidence of disease.

AO-52 - PERINEURAL SPREAD OF HEAD AND NECKCANCER RESULTING IN ORBITAL APEX SYNDROME:REPORT OF FOUR CASES. ANA CAROLINA PRADORIBEIRO, ADRIELE FERREIRA GOUVÊA, MARCOAURELIO PETRONI MONTEZUMA, ALAN ROGERSANTOS-SILVA, ICARO CARVALHO, CRISTIANE MARIAALMEIDA, THAÍS BIANCA BRANDÃO. INSTITUTO DOCÂNCER DO ESTADO DE SÃO PAULO (ICESP).

Perineural invasion is an uncommon type of tumor dissemi-nation that occurs when malignant cells gain access to the peri-neural space and spread along the nerves to distant locations. This,in turn, may result in orbital apex syndrome (OAS). Although rare,OAS typically damages the oculomotor nerve (III), trochlear nerve(IV), abducens nerve (VI), and trigeminal nerve (V) in associationwith optic nerve dysfunction. The authors report four cases of OASdiagnosed in patients undergoing treatment for squamous cellcarcinoma of the nasopharynx (2), larynx (1) and tongue (1). Ptosisand diplopia were detected, leading to the diagnosis of OAS.Clinicopathological data, tomographic and magnetic resonanceimage findings, and follow-up information of all patients is dis-cussed. Early diagnosis is crucial for patients with OAS becausethis disorder carries a poor prognosis. This case series highlightsthe importance of multidisciplinary teams in cancer treatment.

AO-53 - PHENOTYPIC DIFFERENCES IN THREE FAM-ILIES WITH HEREDITARY GINGIVAL FIBROMATOSIS.SABINA PENA BORGES PÊGO, LÍVIA MÁRIS RIBEIROPARANAÍBA, MÁRIO RODRIGUES DE MELO FILHO,RICARDO DELLA COLETTA, SIBELE NASCIMENTOAQUINO, LUCAS RODRIGUES ALVES, HERCÍLIOMARTELLI JÚNIOR. UNIVERSIDADE ESTADUAL DEMONTES CLAROSeUNIMONTES.

Hereditary gingival fibromatosis (HGF) is a rare geneticcondition (1:750.000). Its expression may vary from mild to se-vere. Clinically, there is slow and continuous gingival overgrowththat may lead to partial or full coverage dental clinic crowns. Thisstudy presents clinical, radiographic, and histological comparisonsbetween members of three distinct families. Two conditions areobserved: individuals who have an exuberant growth with partialcoverage of dental crowns and individuals who have only discreetgrowth. Radiographically, there are no changes, and the trans-mission pattern is autosomal dominant in three families. Histo-logically, the epithelium has long, slender ridges that protrude intothe underlying connective tissue, which is characterized by dense,thick collagen fiber bundles. Because HGF may present a varietyof clinical aspects, it is important to associate all aspectsdclinical,radiographic, and histologicaldso that tenuous HGF cases do notremain undiagnosed. Acknowledgement: FAPEMIG.

AO-54 - PHOTODYNAMIC THERAPY: A NEWAPPROACH FOR ACTINIC CHEILITIS? KARLA BIANCAFERNANDES DA COSTA FONTES, REBECA DE SOUZA