[Pancreatic hyperenzymemia: new advances in the field of clinical-diagnostic approach, with particular attention about Gullo's syndrome.] - ResearchGate

http://www.researchgate.net/...80_Pancreatic_hyperenzymemia_new_advances_in_the_field_of_clinical-diagnostic_approach_with_particular_attention_about_Gullo%27s_syndrome[09-Jan-15 1:17:36 PM]

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Article[Pancreatic hyperenzymemia: new advances in the field ofclinical-diagnostic approach, with particular attention aboutGullo's syndrome.]

Unità Operativa Complessa di Medicina Interna "A. Francaviglia", Dipartimento di MedicinaInterna e Patologie Sistemiche, Azienda Ospedaliero-Universitaria, "Policlinico-VittorioEmanuele", Catania, Italia - .Minerva medica (Impact Factor: 1.2). 10/2012; 103(5):393-412.Source: PubMed

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ABSTRACT An increase in serum levels of pancreatic enzymes is a well-knownmanifestation of pancreatic disease, especially of inflammatory or neoplastic nature, even ifseveral extrapancreatic diseases can equally cause that increase. In addition to thispathological type of hyperenzymemia, different "non-pathological" forms have also beenidentified, including macroamylasemia, salivary, and mixed salivary and pancreatichyperamylasemia, in all of which only amylase elevations are seen. Nevertheless, in 1996a new syndrome characterized by an abnormal, chronic, benign increase in levels of serumamylase, pancreatic isoamylase, lipase and trypsin, asymptomatic and usually discoveredincidentally, was described for the first time by Lucio Gullo et al.Hyperamylasemia/hyperlipasemia's observation is nowadays on the increase becausegeneral practitioners tend to include more frequently amylase and lipase in routine bloodtests and, moreover, because the constant evaluation of this biochemical alteration in theEmergency Unit: for this reason, this syndrome was clearly identified only recently.Therefore, it's characterized by serum elevation of all pancreatic enzymes in the absenceof underlying diseases; it occurs in either sporadic or familial form and it persists over timewith considerable fluctuation in serum enzyme concentrations, including frequentnormalizations. Proper diagnosis of this form of hyperenzymemia is important because itreassures the subjects having this anomaly that the syndrome is benign, and because itcan prevent multiple and expensive diagnostic tests or useless hospitalizations ortherapies. [less]

Article: A 5-Year Experience of Benign PancreaticHyperenzymemia.Eleonora Galassi, Chiara Birtolo, Marina Migliori, LucianaBastagli, Veronica Gabusi, Vincenzo Stanghellini, Roberto DeGiorgio

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Pancreas 04/2014; · 3.01 Impact Factor

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[Pancreatic hyperenzymemia: new advances in the field of clinical-diagnostic approach, with particular attention about Gullo's syndrome.] - ResearchGate

http://www.researchgate.net/...80_Pancreatic_hyperenzymemia_new_advances_in_the_field_of_clinical-diagnostic_approach_with_particular_attention_about_Gullo%27s_syndrome[09-Jan-15 1:17:36 PM]

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