pancreatic cancer - national cancer institute · pancreatic cancer is relatively rare (121/ 100,000...
TRANSCRIPT
![Page 1: Pancreatic cancer - National Cancer Institute · Pancreatic Cancer is relatively rare (121/ 100,000 persons) Test with 100% sensitivity' and 99% specificity => 83 talse positive tor](https://reader034.vdocuments.us/reader034/viewer/2022042521/5f57aa964fe39322e825f394/html5/thumbnails/1.jpg)
Pancreatic cancer
![Page 2: Pancreatic cancer - National Cancer Institute · Pancreatic Cancer is relatively rare (121/ 100,000 persons) Test with 100% sensitivity' and 99% specificity => 83 talse positive tor](https://reader034.vdocuments.us/reader034/viewer/2022042521/5f57aa964fe39322e825f394/html5/thumbnails/2.jpg)
Incidence and mortality
![Page 3: Pancreatic cancer - National Cancer Institute · Pancreatic Cancer is relatively rare (121/ 100,000 persons) Test with 100% sensitivity' and 99% specificity => 83 talse positive tor](https://reader034.vdocuments.us/reader034/viewer/2022042521/5f57aa964fe39322e825f394/html5/thumbnails/3.jpg)
Deaths annually increasing
![Page 4: Pancreatic cancer - National Cancer Institute · Pancreatic Cancer is relatively rare (121/ 100,000 persons) Test with 100% sensitivity' and 99% specificity => 83 talse positive tor](https://reader034.vdocuments.us/reader034/viewer/2022042521/5f57aa964fe39322e825f394/html5/thumbnails/4.jpg)
Risk factors
![Page 5: Pancreatic cancer - National Cancer Institute · Pancreatic Cancer is relatively rare (121/ 100,000 persons) Test with 100% sensitivity' and 99% specificity => 83 talse positive tor](https://reader034.vdocuments.us/reader034/viewer/2022042521/5f57aa964fe39322e825f394/html5/thumbnails/5.jpg)
Types and stage
![Page 6: Pancreatic cancer - National Cancer Institute · Pancreatic Cancer is relatively rare (121/ 100,000 persons) Test with 100% sensitivity' and 99% specificity => 83 talse positive tor](https://reader034.vdocuments.us/reader034/viewer/2022042521/5f57aa964fe39322e825f394/html5/thumbnails/6.jpg)
Early detection
![Page 7: Pancreatic cancer - National Cancer Institute · Pancreatic Cancer is relatively rare (121/ 100,000 persons) Test with 100% sensitivity' and 99% specificity => 83 talse positive tor](https://reader034.vdocuments.us/reader034/viewer/2022042521/5f57aa964fe39322e825f394/html5/thumbnails/7.jpg)
Carbohydrate antigen 19-9
![Page 8: Pancreatic cancer - National Cancer Institute · Pancreatic Cancer is relatively rare (121/ 100,000 persons) Test with 100% sensitivity' and 99% specificity => 83 talse positive tor](https://reader034.vdocuments.us/reader034/viewer/2022042521/5f57aa964fe39322e825f394/html5/thumbnails/8.jpg)
Glypican-1 positive exosomes
![Page 9: Pancreatic cancer - National Cancer Institute · Pancreatic Cancer is relatively rare (121/ 100,000 persons) Test with 100% sensitivity' and 99% specificity => 83 talse positive tor](https://reader034.vdocuments.us/reader034/viewer/2022042521/5f57aa964fe39322e825f394/html5/thumbnails/9.jpg)
Carcinogenesis
![Page 10: Pancreatic cancer - National Cancer Institute · Pancreatic Cancer is relatively rare (121/ 100,000 persons) Test with 100% sensitivity' and 99% specificity => 83 talse positive tor](https://reader034.vdocuments.us/reader034/viewer/2022042521/5f57aa964fe39322e825f394/html5/thumbnails/10.jpg)
Early stage disease
![Page 11: Pancreatic cancer - National Cancer Institute · Pancreatic Cancer is relatively rare (121/ 100,000 persons) Test with 100% sensitivity' and 99% specificity => 83 talse positive tor](https://reader034.vdocuments.us/reader034/viewer/2022042521/5f57aa964fe39322e825f394/html5/thumbnails/11.jpg)
Neoantigen qualities
![Page 12: Pancreatic cancer - National Cancer Institute · Pancreatic Cancer is relatively rare (121/ 100,000 persons) Test with 100% sensitivity' and 99% specificity => 83 talse positive tor](https://reader034.vdocuments.us/reader034/viewer/2022042521/5f57aa964fe39322e825f394/html5/thumbnails/12.jpg)
Cancer treatment
![Page 13: Pancreatic cancer - National Cancer Institute · Pancreatic Cancer is relatively rare (121/ 100,000 persons) Test with 100% sensitivity' and 99% specificity => 83 talse positive tor](https://reader034.vdocuments.us/reader034/viewer/2022042521/5f57aa964fe39322e825f394/html5/thumbnails/13.jpg)
Immune checkpoint blockade
![Page 14: Pancreatic cancer - National Cancer Institute · Pancreatic Cancer is relatively rare (121/ 100,000 persons) Test with 100% sensitivity' and 99% specificity => 83 talse positive tor](https://reader034.vdocuments.us/reader034/viewer/2022042521/5f57aa964fe39322e825f394/html5/thumbnails/14.jpg)
Novel immune therapies
![Page 15: Pancreatic cancer - National Cancer Institute · Pancreatic Cancer is relatively rare (121/ 100,000 persons) Test with 100% sensitivity' and 99% specificity => 83 talse positive tor](https://reader034.vdocuments.us/reader034/viewer/2022042521/5f57aa964fe39322e825f394/html5/thumbnails/15.jpg)
Genetic alterations
![Page 16: Pancreatic cancer - National Cancer Institute · Pancreatic Cancer is relatively rare (121/ 100,000 persons) Test with 100% sensitivity' and 99% specificity => 83 talse positive tor](https://reader034.vdocuments.us/reader034/viewer/2022042521/5f57aa964fe39322e825f394/html5/thumbnails/16.jpg)
Precision medicine
![Page 17: Pancreatic cancer - National Cancer Institute · Pancreatic Cancer is relatively rare (121/ 100,000 persons) Test with 100% sensitivity' and 99% specificity => 83 talse positive tor](https://reader034.vdocuments.us/reader034/viewer/2022042521/5f57aa964fe39322e825f394/html5/thumbnails/17.jpg)
iExosomes
![Page 18: Pancreatic cancer - National Cancer Institute · Pancreatic Cancer is relatively rare (121/ 100,000 persons) Test with 100% sensitivity' and 99% specificity => 83 talse positive tor](https://reader034.vdocuments.us/reader034/viewer/2022042521/5f57aa964fe39322e825f394/html5/thumbnails/18.jpg)
Complex microenvironment
![Page 19: Pancreatic cancer - National Cancer Institute · Pancreatic Cancer is relatively rare (121/ 100,000 persons) Test with 100% sensitivity' and 99% specificity => 83 talse positive tor](https://reader034.vdocuments.us/reader034/viewer/2022042521/5f57aa964fe39322e825f394/html5/thumbnails/19.jpg)
Desmoplastic stroma
![Page 20: Pancreatic cancer - National Cancer Institute · Pancreatic Cancer is relatively rare (121/ 100,000 persons) Test with 100% sensitivity' and 99% specificity => 83 talse positive tor](https://reader034.vdocuments.us/reader034/viewer/2022042521/5f57aa964fe39322e825f394/html5/thumbnails/20.jpg)
Cancer associated fibroblasts
![Page 21: Pancreatic cancer - National Cancer Institute · Pancreatic Cancer is relatively rare (121/ 100,000 persons) Test with 100% sensitivity' and 99% specificity => 83 talse positive tor](https://reader034.vdocuments.us/reader034/viewer/2022042521/5f57aa964fe39322e825f394/html5/thumbnails/21.jpg)
Tumor heterogeneity
![Page 22: Pancreatic cancer - National Cancer Institute · Pancreatic Cancer is relatively rare (121/ 100,000 persons) Test with 100% sensitivity' and 99% specificity => 83 talse positive tor](https://reader034.vdocuments.us/reader034/viewer/2022042521/5f57aa964fe39322e825f394/html5/thumbnails/22.jpg)
PDAC subtypes
![Page 23: Pancreatic cancer - National Cancer Institute · Pancreatic Cancer is relatively rare (121/ 100,000 persons) Test with 100% sensitivity' and 99% specificity => 83 talse positive tor](https://reader034.vdocuments.us/reader034/viewer/2022042521/5f57aa964fe39322e825f394/html5/thumbnails/23.jpg)
Classical subtype
![Page 24: Pancreatic cancer - National Cancer Institute · Pancreatic Cancer is relatively rare (121/ 100,000 persons) Test with 100% sensitivity' and 99% specificity => 83 talse positive tor](https://reader034.vdocuments.us/reader034/viewer/2022042521/5f57aa964fe39322e825f394/html5/thumbnails/24.jpg)
Chromosome structure
![Page 25: Pancreatic cancer - National Cancer Institute · Pancreatic Cancer is relatively rare (121/ 100,000 persons) Test with 100% sensitivity' and 99% specificity => 83 talse positive tor](https://reader034.vdocuments.us/reader034/viewer/2022042521/5f57aa964fe39322e825f394/html5/thumbnails/25.jpg)
Stroma specific subtypes
![Page 26: Pancreatic cancer - National Cancer Institute · Pancreatic Cancer is relatively rare (121/ 100,000 persons) Test with 100% sensitivity' and 99% specificity => 83 talse positive tor](https://reader034.vdocuments.us/reader034/viewer/2022042521/5f57aa964fe39322e825f394/html5/thumbnails/26.jpg)
Metabolic reprogramming
![Page 27: Pancreatic cancer - National Cancer Institute · Pancreatic Cancer is relatively rare (121/ 100,000 persons) Test with 100% sensitivity' and 99% specificity => 83 talse positive tor](https://reader034.vdocuments.us/reader034/viewer/2022042521/5f57aa964fe39322e825f394/html5/thumbnails/27.jpg)
Stellate cells
![Page 28: Pancreatic cancer - National Cancer Institute · Pancreatic Cancer is relatively rare (121/ 100,000 persons) Test with 100% sensitivity' and 99% specificity => 83 talse positive tor](https://reader034.vdocuments.us/reader034/viewer/2022042521/5f57aa964fe39322e825f394/html5/thumbnails/28.jpg)
RAS/MAPK
![Page 29: Pancreatic cancer - National Cancer Institute · Pancreatic Cancer is relatively rare (121/ 100,000 persons) Test with 100% sensitivity' and 99% specificity => 83 talse positive tor](https://reader034.vdocuments.us/reader034/viewer/2022042521/5f57aa964fe39322e825f394/html5/thumbnails/29.jpg)
Trametinib plus HCQ
![Page 30: Pancreatic cancer - National Cancer Institute · Pancreatic Cancer is relatively rare (121/ 100,000 persons) Test with 100% sensitivity' and 99% specificity => 83 talse positive tor](https://reader034.vdocuments.us/reader034/viewer/2022042521/5f57aa964fe39322e825f394/html5/thumbnails/30.jpg)
Drug delivery
![Page 31: Pancreatic cancer - National Cancer Institute · Pancreatic Cancer is relatively rare (121/ 100,000 persons) Test with 100% sensitivity' and 99% specificity => 83 talse positive tor](https://reader034.vdocuments.us/reader034/viewer/2022042521/5f57aa964fe39322e825f394/html5/thumbnails/31.jpg)
Mouse model
![Page 32: Pancreatic cancer - National Cancer Institute · Pancreatic Cancer is relatively rare (121/ 100,000 persons) Test with 100% sensitivity' and 99% specificity => 83 talse positive tor](https://reader034.vdocuments.us/reader034/viewer/2022042521/5f57aa964fe39322e825f394/html5/thumbnails/32.jpg)
Stroma targeting
![Page 33: Pancreatic cancer - National Cancer Institute · Pancreatic Cancer is relatively rare (121/ 100,000 persons) Test with 100% sensitivity' and 99% specificity => 83 talse positive tor](https://reader034.vdocuments.us/reader034/viewer/2022042521/5f57aa964fe39322e825f394/html5/thumbnails/33.jpg)
Therapeutic response
![Page 34: Pancreatic cancer - National Cancer Institute · Pancreatic Cancer is relatively rare (121/ 100,000 persons) Test with 100% sensitivity' and 99% specificity => 83 talse positive tor](https://reader034.vdocuments.us/reader034/viewer/2022042521/5f57aa964fe39322e825f394/html5/thumbnails/34.jpg)
Phase II trial
![Page 35: Pancreatic cancer - National Cancer Institute · Pancreatic Cancer is relatively rare (121/ 100,000 persons) Test with 100% sensitivity' and 99% specificity => 83 talse positive tor](https://reader034.vdocuments.us/reader034/viewer/2022042521/5f57aa964fe39322e825f394/html5/thumbnails/35.jpg)
Hedgehog signaling
![Page 36: Pancreatic cancer - National Cancer Institute · Pancreatic Cancer is relatively rare (121/ 100,000 persons) Test with 100% sensitivity' and 99% specificity => 83 talse positive tor](https://reader034.vdocuments.us/reader034/viewer/2022042521/5f57aa964fe39322e825f394/html5/thumbnails/36.jpg)
Tumor suppressor
![Page 37: Pancreatic cancer - National Cancer Institute · Pancreatic Cancer is relatively rare (121/ 100,000 persons) Test with 100% sensitivity' and 99% specificity => 83 talse positive tor](https://reader034.vdocuments.us/reader034/viewer/2022042521/5f57aa964fe39322e825f394/html5/thumbnails/37.jpg)
Myoblast depletion
![Page 38: Pancreatic cancer - National Cancer Institute · Pancreatic Cancer is relatively rare (121/ 100,000 persons) Test with 100% sensitivity' and 99% specificity => 83 talse positive tor](https://reader034.vdocuments.us/reader034/viewer/2022042521/5f57aa964fe39322e825f394/html5/thumbnails/38.jpg)
Overall survival
![Page 39: Pancreatic cancer - National Cancer Institute · Pancreatic Cancer is relatively rare (121/ 100,000 persons) Test with 100% sensitivity' and 99% specificity => 83 talse positive tor](https://reader034.vdocuments.us/reader034/viewer/2022042521/5f57aa964fe39322e825f394/html5/thumbnails/39.jpg)
Anti-stromal therapy
![Page 40: Pancreatic cancer - National Cancer Institute · Pancreatic Cancer is relatively rare (121/ 100,000 persons) Test with 100% sensitivity' and 99% specificity => 83 talse positive tor](https://reader034.vdocuments.us/reader034/viewer/2022042521/5f57aa964fe39322e825f394/html5/thumbnails/40.jpg)
Mesothelin
![Page 41: Pancreatic cancer - National Cancer Institute · Pancreatic Cancer is relatively rare (121/ 100,000 persons) Test with 100% sensitivity' and 99% specificity => 83 talse positive tor](https://reader034.vdocuments.us/reader034/viewer/2022042521/5f57aa964fe39322e825f394/html5/thumbnails/41.jpg)
MSLN expression
![Page 42: Pancreatic cancer - National Cancer Institute · Pancreatic Cancer is relatively rare (121/ 100,000 persons) Test with 100% sensitivity' and 99% specificity => 83 talse positive tor](https://reader034.vdocuments.us/reader034/viewer/2022042521/5f57aa964fe39322e825f394/html5/thumbnails/42.jpg)
MSLN threapeutics
![Page 43: Pancreatic cancer - National Cancer Institute · Pancreatic Cancer is relatively rare (121/ 100,000 persons) Test with 100% sensitivity' and 99% specificity => 83 talse positive tor](https://reader034.vdocuments.us/reader034/viewer/2022042521/5f57aa964fe39322e825f394/html5/thumbnails/43.jpg)
Recombinant immunotoxin
![Page 44: Pancreatic cancer - National Cancer Institute · Pancreatic Cancer is relatively rare (121/ 100,000 persons) Test with 100% sensitivity' and 99% specificity => 83 talse positive tor](https://reader034.vdocuments.us/reader034/viewer/2022042521/5f57aa964fe39322e825f394/html5/thumbnails/44.jpg)
Mechanism of action
![Page 45: Pancreatic cancer - National Cancer Institute · Pancreatic Cancer is relatively rare (121/ 100,000 persons) Test with 100% sensitivity' and 99% specificity => 83 talse positive tor](https://reader034.vdocuments.us/reader034/viewer/2022042521/5f57aa964fe39322e825f394/html5/thumbnails/45.jpg)
LMB-100 plus paclitaxel
![Page 46: Pancreatic cancer - National Cancer Institute · Pancreatic Cancer is relatively rare (121/ 100,000 persons) Test with 100% sensitivity' and 99% specificity => 83 talse positive tor](https://reader034.vdocuments.us/reader034/viewer/2022042521/5f57aa964fe39322e825f394/html5/thumbnails/46.jpg)
Active regimen
![Page 47: Pancreatic cancer - National Cancer Institute · Pancreatic Cancer is relatively rare (121/ 100,000 persons) Test with 100% sensitivity' and 99% specificity => 83 talse positive tor](https://reader034.vdocuments.us/reader034/viewer/2022042521/5f57aa964fe39322e825f394/html5/thumbnails/47.jpg)
Anti-drug antibody
![Page 48: Pancreatic cancer - National Cancer Institute · Pancreatic Cancer is relatively rare (121/ 100,000 persons) Test with 100% sensitivity' and 99% specificity => 83 talse positive tor](https://reader034.vdocuments.us/reader034/viewer/2022042521/5f57aa964fe39322e825f394/html5/thumbnails/48.jpg)
Decreasing ADA
![Page 49: Pancreatic cancer - National Cancer Institute · Pancreatic Cancer is relatively rare (121/ 100,000 persons) Test with 100% sensitivity' and 99% specificity => 83 talse positive tor](https://reader034.vdocuments.us/reader034/viewer/2022042521/5f57aa964fe39322e825f394/html5/thumbnails/49.jpg)
Tofacitinib
![Page 50: Pancreatic cancer - National Cancer Institute · Pancreatic Cancer is relatively rare (121/ 100,000 persons) Test with 100% sensitivity' and 99% specificity => 83 talse positive tor](https://reader034.vdocuments.us/reader034/viewer/2022042521/5f57aa964fe39322e825f394/html5/thumbnails/50.jpg)
Tocacitinib + LMB-100
![Page 51: Pancreatic cancer - National Cancer Institute · Pancreatic Cancer is relatively rare (121/ 100,000 persons) Test with 100% sensitivity' and 99% specificity => 83 talse positive tor](https://reader034.vdocuments.us/reader034/viewer/2022042521/5f57aa964fe39322e825f394/html5/thumbnails/51.jpg)
Questions?