PANCREASPANCREAS

ANATOMYANATOMY

DELICATE LOOSE C.T CAPSULEDELICATE LOOSE C.T CAPSULESOFT LOBULATEDSOFT LOBULATEDHEAD NECK & TAILHEAD NECK & TAILPANCREATIC DUCT PANCREATIC DUCT HEPATO PANCREATIC AMPULLAHEPATO PANCREATIC AMPULLA

PANCREAS PANCREAS

PARENCHYMA PARENCHYMA ENDOCRINE ENDOCRINE EXOCRINE EXOCRINE

STROMA STROMA LOOSE C.T. WITH LOOSE C.T. WITH NUMEROUS B.V. MAST CELLSNUMEROUS B.V. MAST CELLS

EXOCRINE PANCREASEXOCRINE PANCREAS

PANCREATIC ENZYMES PANCREATIC ENZYMES SEROUS GLANDSEROUS GLANDBRANCHED ACINARBRANCHED ACINARSPHERICAL CLUSTER OF PYRAMIDAL SPHERICAL CLUSTER OF PYRAMIDAL

CELLSCELLSCENTROACINAR CELLSCENTROACINAR CELLS

INTRAACINAR PART OF INTERCALATED DUCTINTRAACINAR PART OF INTERCALATED DUCT

SEROUS MUCOUSSEROUS MUCOUS PYRAMIDALPYRAMIDAL PURPLISH RED WITH PURPLISH RED WITH

BASAL BASOPHILIABASAL BASOPHILIA ROUND BASAL NUCLEUSROUND BASAL NUCLEUS

CELL OUTLINES NOT CELL OUTLINES NOT CLEARCLEAR

LUMEN INDISTINCTLUMEN INDISTINCT ZYMOGEN GRANULESZYMOGEN GRANULES MYOEPITHELIAL CELLS are MYOEPITHELIAL CELLS are

PROMINENTPROMINENT

COLUMNARCOLUMNAR LIGHTLY EOSINOPHILICLIGHTLY EOSINOPHILIC

FLATTENED PERIPHERAL FLATTENED PERIPHERAL NUCLEUSNUCLEUS

CLEARCLEAR

DISTINCTDISTINCT MUCINOGEN VESICLESMUCINOGEN VESICLES NOT PROMINENTNOT PROMINENT

SEROUS MUCOUSSEROUS MUCOUS

SEROUS MUCOUSSEROUS MUCOUS

Apical microvilliApical microvilliLaterally Laterally intercellur intercellur

canaliculi, junctional canaliculi, junctional complexes & complexes & infoldingsinfoldings

Golgi complex, RerGolgi complex, Rer Small discrete Small discrete

granules secretion granules secretion < AGAGS< AGAGS

Apical plasma Apical plasma membrane smoothmembrane smooth

Intercellular Intercellular canaliculi rarecanaliculi rare

Dense large closely Dense large closely packed & ill packed & ill defineddefined

> AGAGS> AGAGS

SEROUS MUCOUSSEROUS MUCOUS

DUCT SYSTEMDUCT SYSTEM

INTERCALATED INTERCALATED SIMPLE CUBOIDA;SIMPLE CUBOIDA;

INTRALOBULAR NO STRIATED DUCTINTRALOBULAR NO STRIATED DUCT INTERLOBULARINTERLOBULAR LOW COLUMNAR ENTERO ENDOCRINE GOBLETLOW COLUMNAR ENTERO ENDOCRINE GOBLET

MAIN PANCREATIC DUCT MAIN PANCREATIC DUCT

CONTROL OF EXOCRINE CONTROL OF EXOCRINE SECRETIONSECRETION

HORMONALHORMONALSECRETIN,CCKSECRETIN,CCK

NEURONAL NEURONAL SYMPATHETIC REGULATION OF PANCREATIC BLOOD FLOWSYMPATHETIC REGULATION OF PANCREATIC BLOOD FLOW

PARASYMPATHETIC --- ACINAR & CENTROACINAR CELLSPARASYMPATHETIC --- ACINAR & CENTROACINAR CELLS

HCOHCO33 & H & H22OO DUCTAL & CENTROACINAR CELLS DUCTAL & CENTROACINAR CELLS VAGAL CHOLINERGIC HORMONAL SECRETINVAGAL CHOLINERGIC HORMONAL SECRETIN

ENZYMES ACINAR CELLS ENZYMES ACINAR CELLS VAGAL VAGAL CHOLINERGICCHOLINERGIC HORMONAL HORMONAL CCKCCK

ENDOCRINE PANCREASENDOCRINE PANCREAS ISLETS OF LANGERHANSISLETS OF LANGERHANS CLUSTERS OF PALE STAINING POLYHEDRAL CELLS CLUSTERS OF PALE STAINING POLYHEDRAL CELLS > TAIL > TAIL FENESTRATED CAPILLARIES AUTONOMIC FENESTRATED CAPILLARIES AUTONOMIC

INNERVATIONINNERVATION ALPHA BETA & DELTA ALPHA BETA & DELTA ( MALLORY AZAN)( MALLORY AZAN) BETA 70% CENTRE INSULINBETA 70% CENTRE INSULIN ALPHA 10-15% PERIPHERY GLUCAGON,. GIP, CCK, ACTHALPHA 10-15% PERIPHERY GLUCAGON,. GIP, CCK, ACTH DELTA 10-15% PERIPHERY SOMATOSTATIN GASTRINDELTA 10-15% PERIPHERY SOMATOSTATIN GASTRIN CONTROL OF ENDOCRINE PANCREAS CONTROL OF ENDOCRINE PANCREAS PARASYMPATHETIC INCREASES SECRETION OF INSULIN & PARASYMPATHETIC INCREASES SECRETION OF INSULIN &

GLUCAGONGLUCAGON SYMPATHETIC INCREASES GLUCAGON BUT INHIBITS INSULINSYMPATHETIC INCREASES GLUCAGON BUT INHIBITS INSULIN

GALL BLADDERGALL BLADDER

HISTOLOGY HISTOLOGY

MUCOSAL FOLDS (EMPTY) MUCOSAL FOLDS (EMPTY) COLUMNAR EPITHELIUM COLUMNAR EPITHELIUM WITH MICROVILLI APICAL WITH MICROVILLI APICAL

JUNCTIONAL COMPLEX & MITOCHONDRIA Na K ATPaseJUNCTIONAL COMPLEX & MITOCHONDRIA Na K ATPase

LAMINA PROPRIA LAMINA PROPRIA VASCULAR VASCULAR FENESTRATEDCAPILLARIESFENESTRATEDCAPILLARIES & CELLULAR & CELLULAR (PLASMA CELLS & (PLASMA CELLS & LYMPHOCYTES)LYMPHOCYTES)

MUSCULARIS EXTERNA MUSCULARIS EXTERNA RANDOMLY ORIENTED SMOOTH MUSCLES WITH BUNDLES OF RANDOMLY ORIENTED SMOOTH MUSCLES WITH BUNDLES OF

COLLAGEN & ELASTIC FIBERCOLLAGEN & ELASTIC FIBER

SEROSA / ADVENTITIASEROSA / ADVENTITIA THICK DENSE C.T. BLOOD & LYMPH VESSELS & NERVESTHICK DENSE C.T. BLOOD & LYMPH VESSELS & NERVES

ABSORPTION OF HABSORPTION OF H22O & ELECTROLYTEO & ELECTROLYTE

BILIARY TREE BILIARY TREE

BILE CANALI CULIBILE CANALI CULICANALS OF HERRINGCANALS OF HERRING INTER LOBULAR BILE DUCTSINTER LOBULAR BILE DUCTSRIGHT & LEFT HEPATIC DUCTSRIGHT & LEFT HEPATIC DUCTSCYSTIC DUCT BILE DUCTCYSTIC DUCT BILE DUCT

HISTOLOGYHISTOLOGY

GROOVES B/W ADJACENT GROOVES B/W ADJACENT HEPATOCYTES JUNCTIONAL COMPLEXHEPATOCYTES JUNCTIONAL COMPLEX

SIMPLE CUBOIDAL EPITHELIUM WITH SIMPLE CUBOIDAL EPITHELIUM WITH BASAL LAMINA MICROVILLIBASAL LAMINA MICROVILLI

CUBOIDAL TO COLUMNAR DENSE CUBOIDAL TO COLUMNAR DENSE CONNECTIVE INVESTMENT WITH CONNECTIVE INVESTMENT WITH SMOOTH MUSCLE SMOOTH MUSCLE