pan- and core- genomes in bacteria - dtu …€¦ · comparative microbial genomics group center...

Comparative Microbial Genomics group Center for B

iological Sequence analysis D

epartment of S

ystems B

iology, Technical University of D

enmark

Pan- and Core-Genomes in Bacteria

Dave Ussery

Workshop on Comparative GenomicsKing Mongkut's University of Technology ThonburiBangkok, Thailand

1rst Talk for Wednesday10 March, 2010

1 : Escherichia coli 0157:H7 str. EC4196 2 : Escherichia coli 0157:H7 str. EC4113 3 : Escherichia coli 0157:H7 str. EC508 4 : Escherichia coli 0157:H7 str. EC4501 5 : Escherichia coli 0157:H7 str. EC4076 6 : Escherichia coli 0157:H7 str. EC4115 7 : Escherichia coli 0157:H7 str. EC4042 8 : Escherichia coli 0157:H7 str. EC4486 9 : Escherichia coli 0157:H7 str. EC86910 : Escherichia coli 0157:H7 str. EC420611 : Escherichia coli 0157:H7 str. EC440112 : Escherichia coli 0157:H7 str. EDL93313 : Escherichia coli 0157:H7 str. TW1458814 : Escherichia coli 0157:H7 str. Sakai15 : Escherichia coli 0157:H7 EC404516 : Escherichia coli 0157:H7 str. LANL ECF17 : Escherichia coli 0157:H7 str. LANL ECA18 : Escherichia coli K12 str. DH10B19 : Escherichia coli K12 str. MG165520 : Escherichia coli K12 str. W311021 : Escherichia coli K12 str. DH122 : Escherichia coli BW295223 : Escherichia coli ATCC873924 : Escherichia coli B REL60625 : Escherichia coli BL21 (DE3 Korea)26 : Escherichia coli BL21 (DE3 AU)27 : Escherichia coli BL21 (DE3 DOE)28 : Escherichia coli HS29 : Escherichia coli SE1130 : Escherichia coli IAI131 : Escherichia coli 5598932 : Escherichia coli E24377A33 : Escherichia coli O26:H11 str. 1136834 : Escherichia coli 0127:H6 str. E2348/6935 : Escherichia coli O103:H2 str. 1200936 : Escherichia coli O111:H- str. 1112837 : Escherichia coli 0103 Oslo

39 : Escherichia coli UMN02640 : Escherichia coli 5363841 : Escherichia coli IAI3942 : Escherichia coli UTI8943 : Escherichia coli S8844 : Escherichia coli CFT07345 : Escherichia coli SE1546 : Escherichia coli 53647 : Escherichia coli ED1a48 : Escherichia coli F1149 : Escherichia coli APECO150 : Escherichia coli E11001951 : Escherichia coli E2252 : Escherichia coli B7A

54 : Shigella flexneri 2a 2457T55 : Shigella flexneri 2a 30156 : Shigella flexneri 5 8401

58 : Shigella boydii Sb22759 : Shigella sonnei Ss04660 : Escherichia fergusonii ATCC 3546961 : Escherichia albertii TW0762762 : Salmonella enterica Typhimurium LT263 : Shigella dysenteriae Sd19764 : Shigella dysenteriae 1012

New gene families

Core genome

Pan genome

5000

10000

15000

1 3 5 7 9 11 13 15 17 19 21 23 61 6325 27 33 3729 31 35 39 41 43 45 47 53 5749 51 55 59

Numberof genefamilies



epartment of S

ystems B


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Outline • Diversity within E. coli genomes• Pan- and core-genome plots• A look at diversity within other bacteria• Pan-genome Family Trees



epartment of S

ystems B


enmark

Escherichia coli, strain K-12, isolate W3110

4,641,433 bp 4390 genes

E. coli O157

5,528,445 bp

5,231,428 bpE. coli CFT073

4,227,846 bp

E. coli E2348



epartment of S

ystems B


enmark



epartment of S

ystems B


enmark

LOCUS CP001846 5386352 bp DNA circular BCT 08-MAR-2010DEFINITION Escherichia coli O55:H7 str. CB9615, complete genome.ACCESSION CP001846VERSION CP001846.1 GI:290760697DBLINK Project:42729KEYWORDS .SOURCE Escherichia coli O55:H7 str. CB9615 ORGANISM Escherichia coli O55:H7 str. CB9615 Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales; Enterobacteriaceae; Escherichia.REFERENCE 1 (bases 1 to 5386352) AUTHORS Zhou,Z., Li,X., Liu,B., Beutin,L., Xu,J., Ren,Y., Feng,L., Lan,R., Reeves,P.R. and Wang,L. TITLE Derivation of Escherichia coli O157:H7 from its O55:H7 precursor JOURNAL PLoS ONE 5 (1), E8700 (2010) PUBMED 20090843 REMARK Publication Status: Online-OnlyREFERENCE 2 (bases 1 to 5386352) AUTHORS Wang,L., Zhou,Z., Li,X., Liu,B., Beutin,L., Xu,J., Ren,Y., Feng,L., Lan,R. and Reeves,P.R. TITLE Direct Submission JOURNAL Submitted (22-DEC-2009) TEDA School of Biological Sciences and Biotechnology, Nankai University, No. 23, Hongda Street, TEDA, Tianjin, Tianjin 300457, The People's Republic of ChinaFEATURES Location/Qualifiers source 1..5386352 /organism="Escherichia coli O55:H7 str. CB9615" /mol_type="genomic DNA" /strain="CB9615" /serotype="O55:H7" /isolation_source="infant with diarrhea"

4.7 %180 / 3,817

90.6 %3,635 / 4,010

92.2 %3,748 / 4,064

95.2 %3,784 / 3,974

61.5 %3,387 / 5,503

6.4 %242 / 3,797

93.1 %3,742 / 4,020

91.5 %3,685 / 4,027

57.7 %3,306 / 5,733

4.3 %170 / 3,965

95.3 %3,843 / 4,034

59.6 %3,440 / 5,774

4.3 %167 / 3,912

59.7 %3,427 / 5,736

7.4 %348 / 4,686

Escherichia coli

strain BW2952

4,084 proteins, 3,817 families

Escherichia coli

strain K-12, substrain D

H10B


Escherichia coli

strain K-12, substrain W

3110


Escherichia coli

strain K-12, substrain M

G1655


Escherichia coli

serotype O157:H

7 strain EC4115


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W29

52

4,08

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subst

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4,12

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W31

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4,22

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1655

4,15

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type

O15

7:H

7 st

rain

EC41

15

5,47

7 pro

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686

fam

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5 E. coli genomes

4.7 %180 / 3,817

80.8 %3,461 / 4,283

83.3 %3,537 / 4,247

83.7 %3,555 / 4,249

82.3 %3,534 / 4,293

82.8 %3,562 / 4,301

90.6 %3,635 / 4,010

92.2 %3,748 / 4,064

95.2 %3,784 / 3,974

78.3 %3,541 / 4,521

74.8 %3,458 / 4,620

67.6 %3,360 / 4,967

68.6 %3,392 / 4,947

73.5 %3,540 / 4,817

68.3 %3,428 / 5,021

60.8 %3,213 / 5,287

68.3 %3,440 / 5,039

64.3 %3,340 / 5,191

67.7 %3,481 / 5,144

72.0 %3,597 / 4,999

69.1 %3,517 / 5,088

63.1 %3,412 / 5,407

60.3 %3,374 / 5,595

66.9 %3,347 / 5,002

64.0 %3,461 / 5,408

63.2 %3,452 / 5,458

63.5 %3,484 / 5,487

61.5 %3,387 / 5,503

62.6 %3,109 / 4,963

67.1 %3,027 / 4,511

63.7 %3,065 / 4,814

67.0 %3,079 / 4,595

62.6 %3,015 / 4,818

56.8 %2,912 / 5,130

54.3 %2,797 / 5,155

67.2 %3,191 / 4,749

4.0 %154 / 3,833

93.6 %3,742 / 4,000

89.1 %3,686 / 4,138

90.2 %3,691 / 4,093

79.5 %3,491 / 4,393

79.3 %3,403 / 4,294

82.3 %3,550 / 4,313

81.0 %3,493 / 4,310

75.4 %3,472 / 4,606

73.8 %3,403 / 4,614

66.2 %3,326 / 5,023

68.3 %3,372 / 4,934

71.0 %3,461 / 4,878

66.9 %3,387 / 5,066

59.7 %3,174 / 5,314

66.2 %3,409 / 5,153

63.6 %3,305 / 5,196

65.8 %3,429 / 5,209

69.6 %3,529 / 5,070

66.7 %3,439 / 5,159

61.8 %3,366 / 5,446

58.8 %3,332 / 5,667

65.2 %3,293 / 5,054

62.2 %3,388 / 5,445

61.6 %3,380 / 5,491

61.5 %3,412 / 5,551

58.2 %3,311 / 5,689

59.6 %3,003 / 5,040

64.8 %2,939 / 4,537

61.6 %2,973 / 4,830

64.4 %2,984 / 4,633

61.4 %2,966 / 4,834

55.3 %2,843 / 5,138

53.4 %2,727 / 5,105

66.0 %3,115 / 4,723

3.9 %154 / 3,900

91.9 %3,774 / 4,108

95.6 %3,832 / 4,007

81.5 %3,566 / 4,373

81.2 %3,470 / 4,271

84.3 %3,616 / 4,287

83.6 %3,573 / 4,274

77.3 %3,543 / 4,584

75.4 %3,470 / 4,603

67.6 %3,387 / 5,009

69.9 %3,440 / 4,919

73.0 %3,536 / 4,847

68.6 %3,461 / 5,045

61.2 %3,243 / 5,296

67.9 %3,481 / 5,124

65.2 %3,372 / 5,174

67.3 %3,493 / 5,188

71.4 %3,602 / 5,048

68.5 %3,517 / 5,137

63.2 %3,432 / 5,431

60.2 %3,398 / 5,641

66.8 %3,364 / 5,033

64.1 %3,465 / 5,409

63.1 %3,446 / 5,464

63.1 %3,486 / 5,522

59.8 %3,381 / 5,658

60.9 %3,067 / 5,033

66.6 %2,998 / 4,504

63.1 %3,025 / 4,797

66.1 %3,040 / 4,598

62.9 %3,020 / 4,804

56.5 %2,887 / 5,113

54.5 %2,771 / 5,087

67.7 %3,173 / 4,684

4.3 %168 / 3,946

88.4 %3,717 / 4,203

81.4 %3,598 / 4,422

80.4 %3,484 / 4,334

83.3 %3,628 / 4,353

83.7 %3,610 / 4,312

77.5 %3,584 / 4,623

76.1 %3,520 / 4,628

67.5 %3,416 / 5,062

69.6 %3,467 / 4,979

73.0 %3,570 / 4,890

68.2 %3,485 / 5,108

60.8 %3,261 / 5,363

69.3 %3,530 / 5,091

65.0 %3,398 / 5,231

68.1 %3,552 / 5,217

71.6 %3,645 / 5,091

68.5 %3,549 / 5,179

63.6 %3,478 / 5,467

60.7 %3,447 / 5,680

66.6 %3,388 / 5,087

63.6 %3,489 / 5,484

63.4 %3,494 / 5,514

62.8 %3,509 / 5,591

61.9 %3,454 / 5,578

61.1 %3,101 / 5,078

65.0 %3,004 / 4,620

62.5 %3,052 / 4,884

65.7 %3,077 / 4,682

61.4 %3,037 / 4,943

56.7 %2,939 / 5,186

53.4 %2,782 / 5,211

66.9 %3,201 / 4,782

4.2 %165 / 3,936

81.5 %3,580 / 4,393

81.3 %3,490 / 4,291

84.7 %3,644 / 4,304

84.0 %3,602 / 4,288

76.5 %3,548 / 4,639

75.7 %3,495 / 4,617

67.4 %3,394 / 5,033

69.2 %3,442 / 4,976

72.1 %3,538 / 4,909

68.2 %3,472 / 5,093

61.1 %3,258 / 5,334

68.7 %3,516 / 5,115

65.2 %3,389 / 5,201

67.9 %3,522 / 5,190

70.4 %3,605 / 5,124

67.7 %3,529 / 5,209

62.6 %3,433 / 5,488

60.2 %3,412 / 5,668

66.5 %3,375 / 5,076

62.6 %3,462 / 5,530

62.1 %3,456 / 5,567

62.0 %3,485 / 5,619

58.8 %3,392 / 5,773

60.6 %3,074 / 5,073

66.4 %3,014 / 4,536

62.9 %3,041 / 4,834

65.5 %3,045 / 4,647

62.7 %3,034 / 4,836

55.8 %2,891 / 5,178

54.5 %2,786 / 5,114

67.1 %3,175 / 4,731

3.9 %156 / 3,977

80.9 %3,497 / 4,322

83.3 %3,629 / 4,359

83.5 %3,606 / 4,320

79.4 %3,618 / 4,559

77.6 %3,572 / 4,606

67.5 %3,404 / 5,043

68.9 %3,469 / 5,034

74.7 %3,622 / 4,851

68.0 %3,477 / 5,116

60.4 %3,261 / 5,400

69.9 %3,575 / 5,111

64.7 %3,398 / 5,252

68.6 %3,564 / 5,197

72.2 %3,662 / 5,073

69.2 %3,582 / 5,177

62.5 %3,444 / 5,512

60.8 %3,446 / 5,665

67.4 %3,408 / 5,054

64.8 %3,534 / 5,451

64.3 %3,531 / 5,492

64.3 %3,556 / 5,534

61.5 %3,474 / 5,651

62.0 %3,126 / 5,045

63.8 %3,038 / 4,761

61.3 %3,088 / 5,034

65.1 %3,088 / 4,740

62.5 %3,070 / 4,910

55.9 %2,946 / 5,267

51.8 %2,803 / 5,413

66.4 %3,228 / 4,862

6.4 %242 / 3,797

93.1 %3,742 / 4,020

91.5 %3,685 / 4,027

76.0 %3,467 / 4,564

72.7 %3,385 / 4,653

65.5 %3,277 / 5,004

66.3 %3,317 / 5,006

71.7 %3,479 / 4,855

65.2 %3,337 / 5,116

58.2 %3,126 / 5,375

66.0 %3,383 / 5,128

61.9 %3,257 / 5,258

66.5 %3,428 / 5,157

70.0 %3,535 / 5,050

66.6 %3,435 / 5,157

60.4 %3,318 / 5,496

57.9 %3,288 / 5,681

64.2 %3,254 / 5,069

61.8 %3,390 / 5,488

60.8 %3,378 / 5,552

61.5 %3,416 / 5,557

57.7 %3,306 / 5,733

60.4 %3,026 / 5,007

65.0 %2,945 / 4,532

61.6 %2,984 / 4,841

64.4 %2,991 / 4,645

60.5 %2,934 / 4,847

54.6 %2,827 / 5,176

53.0 %2,740 / 5,167

65.1 %3,116 / 4,787

4.3 %170 / 3,965

95.3 %3,843 / 4,034

78.3 %3,604 / 4,605

75.7 %3,531 / 4,664

67.3 %3,401 / 5,050

68.9 %3,455 / 5,017

74.0 %3,618 / 4,889

67.7 %3,476 / 5,131

60.6 %3,262 / 5,380

68.7 %3,526 / 5,136

63.8 %3,375 / 5,293

68.9 %3,566 / 5,174

72.6 %3,680 / 5,068

69.3 %3,588 / 5,176

62.7 %3,455 / 5,514

59.6 %3,408 / 5,716

66.1 %3,376 / 5,111

64.1 %3,537 / 5,521

63.1 %3,519 / 5,581

63.7 %3,559 / 5,587

59.6 %3,440 / 5,774

62.0 %3,139 / 5,062

66.3 %3,046 / 4,593

63.0 %3,086 / 4,900

66.0 %3,098 / 4,691

62.1 %3,047 / 4,909

55.9 %2,923 / 5,231

53.8 %2,818 / 5,234

66.5 %3,224 / 4,849

4.3 %167 / 3,912

78.5 %3,580 / 4,560

75.8 %3,508 / 4,628

67.8 %3,389 / 5,000

68.7 %3,435 / 4,997

73.6 %3,584 / 4,867

67.9 %3,460 / 5,093

60.7 %3,245 / 5,348

68.9 %3,513 / 5,099

64.0 %3,361 / 5,254

68.8 %3,542 / 5,149

72.0 %3,643 / 5,057

68.9 %3,556 / 5,162

63.0 %3,443 / 5,463

60.0 %3,399 / 5,669

66.9 %3,375 / 5,046

63.4 %3,494 / 5,512

62.7 %3,489 / 5,564

63.1 %3,519 / 5,577

59.7 %3,427 / 5,736

62.6 %3,129 / 5,000

66.1 %3,025 / 4,576

62.7 %3,065 / 4,885

66.0 %3,078 / 4,664

62.0 %3,026 / 4,880

55.8 %2,912 / 5,221

53.7 %2,801 / 5,213

66.6 %3,204 / 4,812

4.0 %165 / 4,142

74.6 %3,578 / 4,799

67.2 %3,460 / 5,151

68.2 %3,515 / 5,157

79.5 %3,828 / 4,816

67.1 %3,521 / 5,250

59.0 %3,273 / 5,544

67.4 %3,583 / 5,313

64.0 %3,453 / 5,398

71.2 %3,718 / 5,225

75.8 %3,821 / 5,040

70.6 %3,690 / 5,227

62.4 %3,500 / 5,610

58.8 %3,437 / 5,842

66.4 %3,437 / 5,175

64.5 %3,578 / 5,546

64.4 %3,590 / 5,577

64.2 %3,612 / 5,623

61.7 %3,532 / 5,720

61.5 %3,179 / 5,170

60.7 %3,062 / 5,047

58.2 %3,107 / 5,342

62.3 %3,126 / 5,020

58.1 %3,069 / 5,283

53.4 %2,983 / 5,588

48.7 %2,825 / 5,795

63.2 %3,285 / 5,198

3.3 %138 / 4,121

64.0 %3,378 / 5,275

64.4 %3,399 / 5,281

70.4 %3,581 / 5,087

64.9 %3,462 / 5,334

57.7 %3,232 / 5,601

65.8 %3,527 / 5,361

60.9 %3,347 / 5,499

70.8 %3,682 / 5,201

69.9 %3,671 / 5,250

63.1 %3,475 / 5,504

61.5 %3,484 / 5,661

58.5 %3,439 / 5,876

62.4 %3,336 / 5,344

59.1 %3,425 / 5,796

60.0 %3,475 / 5,788

58.9 %3,458 / 5,867

57.2 %3,417 / 5,977

58.5 %3,086 / 5,276

61.1 %2,987 / 4,891

58.3 %3,030 / 5,200

61.2 %3,044 / 4,977

58.4 %3,014 / 5,163

54.3 %2,928 / 5,389

49.8 %2,766 / 5,554

61.4 %3,169 / 5,164

4.4 %191 / 4,327

68.1 %3,518 / 5,165

65.7 %3,518 / 5,356

73.3 %3,776 / 5,148

66.4 %3,592 / 5,406

65.4 %3,568 / 5,458

67.3 %3,633 / 5,396

61.3 %3,468 / 5,656

62.4 %3,518 / 5,638

63.5 %3,532 / 5,563

74.1 %3,939 / 5,313

71.0 %3,869 / 5,448

67.1 %3,527 / 5,259

57.7 %3,416 / 5,921

57.6 %3,426 / 5,951

57.5 %3,440 / 5,982

55.1 %3,372 / 6,121

56.9 %3,124 / 5,488

55.9 %2,964 / 5,299

54.3 %3,009 / 5,538

56.2 %3,002 / 5,345

54.6 %2,969 / 5,433

50.7 %2,898 / 5,716

47.2 %2,796 / 5,919

56.1 %3,126 / 5,572

5.6 %236 / 4,244

67.7 %3,578 / 5,285

68.9 %3,617 / 5,251

62.7 %3,428 / 5,471

69.8 %3,695 / 5,291

65.0 %3,515 / 5,409

61.0 %3,470 / 5,685

63.2 %3,547 / 5,611

68.3 %3,677 / 5,385

64.4 %3,613 / 5,608

61.9 %3,558 / 5,749

64.3 %3,449 / 5,364

60.6 %3,518 / 5,809

60.2 %3,515 / 5,838

60.2 %3,542 / 5,887

57.8 %3,462 / 5,991

57.0 %3,136 / 5,500

61.1 %2,994 / 4,898

59.5 %3,045 / 5,121

61.5 %3,060 / 4,973

59.0 %3,020 / 5,122

52.9 %2,911 / 5,500

50.4 %2,803 / 5,556

62.0 %3,160 / 5,098

5.3 %230 / 4,376

67.9 %3,635 / 5,352

59.5 %3,386 / 5,687

65.2 %3,605 / 5,527

65.7 %3,574 / 5,444

69.5 %3,741 / 5,385

72.2 %3,839 / 5,319

69.2 %3,734 / 5,393

63.2 %3,618 / 5,728

59.3 %3,530 / 5,951

64.2 %3,476 / 5,418

64.9 %3,656 / 5,635

64.9 %3,659 / 5,640

64.4 %3,682 / 5,720

61.8 %3,593 / 5,814

58.0 %3,184 / 5,488

61.0 %3,077 / 5,044

59.6 %3,137 / 5,266

61.1 %3,143 / 5,140

58.0 %3,092 / 5,333

54.7 %3,001 / 5,491

52.1 %2,838 / 5,444

62.4 %3,284 / 5,263

5.2 %233 / 4,485

76.6 %3,926 / 5,127

67.0 %3,695 / 5,511

72.4 %3,812 / 5,265

61.3 %3,532 / 5,764

62.4 %3,573 / 5,724

68.6 %3,759 / 5,480

77.2 %4,088 / 5,295

69.7 %3,888 / 5,582

68.9 %3,650 / 5,299

59.5 %3,512 / 5,901

60.3 %3,545 / 5,880

58.9 %3,527 / 5,990

57.7 %3,487 / 6,041

58.7 %3,238 / 5,518

57.8 %2,997 / 5,183

56.1 %3,043 / 5,426

57.7 %3,053 / 5,293

57.3 %3,051 / 5,329

53.2 %2,966 / 5,571

51.3 %2,826 / 5,513

58.6 %3,193 / 5,446

5.3 %238 / 4,526

61.5 %3,510 / 5,706

62.8 %3,537 / 5,629

55.3 %3,328 / 6,013

57.0 %3,396 / 5,954

59.7 %3,483 / 5,830

70.8 %3,920 / 5,540

62.9 %3,685 / 5,862

62.5 %3,468 / 5,552

54.4 %3,337 / 6,130

54.7 %3,351 / 6,123

54.2 %3,358 / 6,194

52.3 %3,291 / 6,294

52.9 %3,045 / 5,752

52.8 %2,843 / 5,382

51.3 %2,891 / 5,633

53.1 %2,901 / 5,459

51.6 %2,868 / 5,562

48.2 %2,785 / 5,784

45.8 %2,650 / 5,781

53.0 %3,008 / 5,672

5.1 %232 / 4,551

62.0 %3,540 / 5,714

64.3 %3,654 / 5,679

64.6 %3,694 / 5,717

67.6 %3,794 / 5,609

63.9 %3,729 / 5,835

61.0 %3,660 / 6,000

63.9 %3,558 / 5,564

61.0 %3,635 / 5,960

62.0 %3,686 / 5,943

61.0 %3,657 / 5,998

63.0 %3,722 / 5,905

55.4 %3,163 / 5,710

58.5 %3,049 / 5,208

57.2 %3,111 / 5,435

59.0 %3,122 / 5,291

57.2 %3,081 / 5,389

53.8 %3,025 / 5,623

49.3 %2,870 / 5,818

59.3 %3,234 / 5,452

6.0 %268 / 4,451

58.1 %3,429 / 5,898

59.7 %3,493 / 5,854

63.4 %3,600 / 5,678

65.2 %3,741 / 5,742

64.0 %3,732 / 5,835

65.0 %3,548 / 5,458

60.0 %3,496 / 5,822

59.7 %3,496 / 5,853

59.2 %3,507 / 5,924

57.0 %3,439 / 6,035

54.7 %3,124 / 5,707

56.6 %2,973 / 5,254

54.6 %3,015 / 5,518

55.3 %2,991 / 5,407

55.4 %3,019 / 5,449

52.3 %2,936 / 5,609

50.1 %2,789 / 5,563

57.2 %3,140 / 5,493

5.0 %232 / 4,605

71.1 %3,902 / 5,490

62.6 %3,630 / 5,803

59.5 %3,585 / 6,024

56.7 %3,535 / 6,231

59.4 %3,425 / 5,763

59.0 %3,579 / 6,067

60.0 %3,624 / 6,039

58.9 %3,605 / 6,124

58.3 %3,599 / 6,176

53.7 %3,131 / 5,827

57.8 %3,038 / 5,257

56.7 %3,106 / 5,474

58.0 %3,109 / 5,356

55.3 %3,044 / 5,509

53.0 %3,019 / 5,698

51.0 %2,836 / 5,566

60.7 %3,275 / 5,392

5.2 %241 / 4,663

64.9 %3,714 / 5,725

61.3 %3,665 / 5,975

56.8 %3,549 / 6,249

62.0 %3,511 / 5,662

63.6 %3,729 / 5,861

63.0 %3,715 / 5,900

62.6 %3,733 / 5,959

60.4 %3,657 / 6,058

55.7 %3,201 / 5,745

59.5 %3,115 / 5,238

58.5 %3,190 / 5,455

59.8 %3,180 / 5,315

58.1 %3,140 / 5,407

54.1 %3,070 / 5,678

50.8 %2,865 / 5,642

61.1 %3,332 / 5,451

5.0 %236 / 4,676

63.8 %3,746 / 5,875

59.1 %3,608 / 6,107

62.4 %3,521 / 5,647

62.9 %3,706 / 5,889

62.8 %3,708 / 5,902

62.8 %3,739 / 5,958

60.2 %3,651 / 6,061

58.0 %3,281 / 5,653

59.2 %3,081 / 5,205

58.4 %3,158 / 5,408

59.5 %3,144 / 5,286

56.0 %3,073 / 5,486

53.1 %3,014 / 5,679

49.6 %2,886 / 5,817

62.2 %3,308 / 5,316

4.8 %232 / 4,866

73.7 %4,167 / 5,651

65.7 %3,686 / 5,607

57.6 %3,574 / 6,200

57.5 %3,579 / 6,224

57.1 %3,588 / 6,283

55.5 %3,534 / 6,367

55.2 %3,237 / 5,869

54.0 %3,014 / 5,577

52.6 %3,068 / 5,835

53.7 %3,055 / 5,686

53.6 %3,066 / 5,716

50.8 %3,008 / 5,922

48.3 %2,844 / 5,894

55.3 %3,202 / 5,789

5.3 %261 / 4,913

61.1 %3,578 / 5,853

53.8 %3,468 / 6,443

54.1 %3,491 / 6,452

53.7 %3,488 / 6,497

53.0 %3,481 / 6,567

51.1 %3,145 / 6,154

52.2 %2,982 / 5,710

51.4 %3,042 / 5,915

52.4 %3,012 / 5,749

52.2 %3,027 / 5,800

49.0 %2,970 / 6,061

45.2 %2,793 / 6,182

53.6 %3,134 / 5,850

5.0 %218 / 4,327

62.5 %3,541 / 5,668

62.6 %3,542 / 5,659

61.9 %3,550 / 5,736

59.4 %3,476 / 5,850

57.0 %3,124 / 5,485

55.8 %2,980 / 5,336

54.1 %3,022 / 5,583

56.0 %3,001 / 5,357

55.6 %3,036 / 5,464

51.2 %2,933 / 5,728

49.0 %2,804 / 5,723

55.5 %3,127 / 5,639

6.5 %307 / 4,692

85.4 %4,339 / 5,078

87.3 %4,416 / 5,061

78.2 %4,178 / 5,341

51.8 %3,134 / 6,054

56.6 %3,075 / 5,430

55.7 %3,147 / 5,652

56.5 %3,128 / 5,535

55.1 %3,089 / 5,606

51.0 %2,977 / 5,839

51.1 %2,938 / 5,747

58.3 %3,258 / 5,585

6.8 %320 / 4,711

86.6 %4,398 / 5,077

84.5 %4,359 / 5,158

51.6 %3,139 / 6,084

55.2 %3,038 / 5,508

54.6 %3,121 / 5,713

55.5 %3,107 / 5,595

54.5 %3,081 / 5,650

51.1 %2,993 / 5,860

50.5 %2,917 / 5,779

57.7 %3,247 / 5,632

7.8 %371 / 4,729

77.1 %4,173 / 5,409

51.2 %3,146 / 6,142

55.3 %3,098 / 5,599

54.6 %3,168 / 5,797

56.0 %3,142 / 5,614

54.7 %3,103 / 5,671

50.3 %2,985 / 5,934

49.5 %2,951 / 5,956

58.1 %3,286 / 5,652

7.4 %348 / 4,686

50.0 %3,105 / 6,216

51.9 %2,991 / 5,767

51.5 %3,068 / 5,962

53.7 %3,076 / 5,729

52.2 %3,036 / 5,812

51.1 %3,027 / 5,918

44.8 %2,865 / 6,398

55.0 %3,192 / 5,801

3.7 %151 / 4,136

53.8 %2,755 / 5,124

51.7 %2,797 / 5,408

54.4 %2,822 / 5,187

51.6 %2,768 / 5,364

47.5 %2,702 / 5,686

46.2 %2,618 / 5,672

54.3 %2,915 / 5,371

4.0 %138 / 3,449

84.5 %3,283 / 3,886

81.1 %3,153 / 3,890

63.8 %2,813 / 4,411

58.4 %2,733 / 4,677

59.9 %2,635 / 4,396

66.0 %2,921 / 4,428

5.1 %187 / 3,663

80.1 %3,211 / 4,009

65.0 %2,884 / 4,434

60.8 %2,856 / 4,696

61.1 %2,758 / 4,512

67.7 %3,051 / 4,508

4.6 %160 / 3,501

67.0 %2,837 / 4,237

60.4 %2,778 / 4,597

59.0 %2,667 / 4,524

66.8 %2,993 / 4,481

3.6 %126 / 3,472

68.5 %2,981 / 4,350

57.9 %2,698 / 4,656

68.0 %3,011 / 4,427

4.5 %168 / 3,700

53.8 %2,692 / 5,007

61.6 %2,951 / 4,791

3.4 %115 / 3,371

61.9 %2,837 / 4,581

4.6 %171 / 3,727

Escherichia coli

strain BW2952


Escherichia colistrain BL21


Escherichia coli

strain BL21(DE3) - Korea Res IBB


Escherichia coli

strain BL21(DE3) - JG

I


Escherichia coli

B strain REL606


Escherichia coli

strain ATCC 8739


Escherichia coli

strain K-12, substrain DH

10B


Escherichia coli

strain K-12, substrain W3110


Escherichia coli

strain K-12, substrain MG

1655


Escherichia colistrain IA

I1


Escherichia colistrain H

S


Escherichia colistrain 536



I39




Escherichia colistrain S88


Escherichia coli

strain APEC O

1


Escherichia coli

strain SMS-3-5


Escherichia colistrain ED

1a


Escherichia coli

strain E24377A


Escherichia colistrain SE11


Escherichia coli

strain UM

N026


Escherichia coli

strain UTI89


Escherichia coli

strain CFT073


Escherichia coli

serotype O127:H

6 strain E2348/69


Escherichia coli

serotype O157:H

7 strain Sakai


Escherichia coli

serotype O157:H

7 strain TW14359


Escherichia coli

serotype O157:H

7 strain EDL933


Escherichia coli

serotype O157:H

7 strain EC4115


Escherichia fergusonii

strain ATCC 35469


Shigella flexneri

2a strain 2457T


Shigella flexneri

2a strain 301


Shigella flexneri

5 strain 8401


Shigella boydiistrain Sb227


Shigella boydii

strain CDC 3083-94


Shigella dysenteriaestrain Sd197


Shigella sonneistrain Ss046


Esche

richi

a coli

stra

in B

W29

52

4,08

4 pro

tein

s, 3,

817

fam

ilies

Esche

richi

a coli

stra

in B

L21

4,08

7 pro

tein

s, 3,

833

fam

ilies

Esche

richi

a coli

stra

in B

L21(D

E3) -

Korea

Res IB

B

4,15

3 pro

tein

s, 3,

900

fam

ilies

Esche

richi

a coli

stra

in B

L21(D

E3) -

JGI

4,22

8 pro

tein

s, 3,

946

fam

ilies

Esche

richi

a coli

B stra

in R

EL606

4,20

5 pro

tein

s, 3,

936

fam

ilies

Esche

richi

a coli

stra

in A

TCC 873

9

4,20

0 pro

tein

s, 3,

977

fam

ilies

Esche

richi

a coli

stra

in K

-12,

subst

rain

DH

10B

4,12

6 pro

tein

s, 3,

797

fam

ilies

Esche

richi

a coli

stra

in K

-12,

subst

rain

W31

10

4,22

6 pro

tein

s, 3,

965

fam

ilies

Esche

richi

a coli

stra

in K

-12,

subst

rain

MG

1655

4,15

0 pro

tein

s, 3,

912

fam

ilies

Esche

richi

a coli

stra

in IA

I1

4,35

3 pro

tein

s, 4,

142

fam

ilies

Esche

richi

a coli

stra

in H

S

4,37

8 pro

tein

s, 4,

121

fam

ilies

Esche

richi

a coli

stra

in 5

36

4,62

0 pro

tein

s, 4,

327

fam

ilies

Esche

richi

a coli

stra

in IA

I39

4,73

2 pro

tein

s, 4,

244

fam

ilies

Esche

richi

a coli

stra

in 5

5989

4,76

3 pro

tein

s, 4,

376

fam

ilies

Esche

richi

a coli

stra

in S

88

4,83

2 pro

tein

s, 4,

485

fam

ilies

Esche

richi

a coli

stra

in A

PEC O1

4,85

1 pro

tein

s, 4,

526

fam

ilies

Esche

richi

a coli

stra

in S

MS-

3-5

4,91

3 pro

tein

s, 4,

551

fam

ilies

Esche

richi

a coli

stra

in E

D1a

4,91

5 pro

tein

s, 4,

451

fam

ilies

Esche

richi

a coli

stra

in E

2437

7A

4,99

1 pro

tein

s, 4,

605

fam

ilies

Esche

richi

a coli

stra

in S

E11

5,00

2 pro

tein

s, 4,

663

fam

ilies

Esche

richi

a coli

stra

in U

MN

026

5,01

7 pro

tein

s, 4,

676

fam

ilies

Esche

richi

a coli

stra

in U

TI89

5,16

6 pro

tein

s, 4,

866

fam

ilies

Esche

richi

a coli

stra

in C

FT073

5,33

9 pro

tein

s, 4,

913

fam

ilies

Esche

richi

a coli

sero

type O

127:

H6

stra

in E

2348

/69

4,65

3 pro

tein

s, 4,

327

fam

ilies

Esche

richi

a coli

sero

type O

157:

H7

stra

in S

akai

5,31

8 pro

tein

s, 4,

692

fam

ilies

Esche

richi

a coli

sero

type O

157:

H7

stra

in T

W14

359

5,37

2 pro

tein

s, 4,

711

fam

ilies

Esche

richi

a coli

sero

type O

157:

H7

stra

in E

DL93

3

5,41

1 pro

tein

s, 4,

729

fam

ilies

Esche

richi

a coli

sero

type O

157:

H7

stra

in E

C4115

5,47

7 pro

tein

s, 4,

686

fam

ilies

Esche

richi

a fer

guso

nii

stra

in A

TCC 354

69

4,32

1 pro

tein

s, 4,

136

fam

ilies

Shige

lla fl

exner

i

2a st

rain

245

7T

4,06

1 pro

tein

s, 3,

449

fam

ilies

Shige

lla fl

exner

i

2a st

rain

301

4,44

0 pro

tein

s, 3,

663

fam

ilies

Shige

lla fl

exner

i

5 st

rain

840

1

4,11

5 pro

tein

s, 3,

501

fam

ilies

Shige

lla bo

ydii

stra

in S

b227

4,28

2 pro

tein

s, 3,

472

fam

ilies

Shige

lla bo

ydii

stra

in C

DC 3

083-

94

4,55

7 pro

tein

s, 3,

700

fam

ilies

Shige

lla d

ysen

teriae

stra

in S

d197

4,50

2 pro

tein

s, 3,

371

fam

ilies

Shige

lla so

nnei

stra

in S

s046

4,47

1 pro

tein

s, 3,

727

fam

ilies

4.7 %180 / 3,817

80.8 %3,461 / 4,283

83.3 %3,537 / 4,247

83.7 %3,555 / 4,249

82.3 %3,534 / 4,293

82.8 %3,562 / 4,301

90.6 %3,635 / 4,010

92.2 %3,748 / 4,064

95.2 %3,784 / 3,974

78.3 %3,541 / 4,521

74.8 %3,458 / 4,620

67.6 %3,360 / 4,967

68.6 %3,392 / 4,947

73.5 %3,540 / 4,817

68.3 %3,428 / 5,021

60.8 %3,213 / 5,287

68.3 %3,440 / 5,039

64.3 %3,340 / 5,191

67.7 %3,481 / 5,144

72.0 %3,597 / 4,999

69.1 %3,517 / 5,088

63.1 %3,412 / 5,407

60.3 %3,374 / 5,595

66.9 %3,347 / 5,002

64.0 %3,461 / 5,408

63.2 %3,452 / 5,458

63.5 %3,484 / 5,487

61.5 %3,387 / 5,503

62.6 %3,109 / 4,963

67.1 %3,027 / 4,511

63.7 %3,065 / 4,814

67.0 %3,079 / 4,595

62.6 %3,015 / 4,818

56.8 %2,912 / 5,130

54.3 %2,797 / 5,155

67.2 %3,191 / 4,749

4.0 %154 / 3,833

93.6 %3,742 / 4,000

89.1 %3,686 / 4,138

90.2 %3,691 / 4,093

79.5 %3,491 / 4,393

79.3 %3,403 / 4,294

82.3 %3,550 / 4,313

81.0 %3,493 / 4,310

75.4 %3,472 / 4,606

73.8 %3,403 / 4,614

66.2 %3,326 / 5,023

68.3 %3,372 / 4,934

71.0 %3,461 / 4,878

66.9 %3,387 / 5,066

59.7 %3,174 / 5,314

66.2 %3,409 / 5,153

63.6 %3,305 / 5,196

65.8 %3,429 / 5,209

69.6 %3,529 / 5,070

66.7 %3,439 / 5,159

61.8 %3,366 / 5,446

58.8 %3,332 / 5,667

65.2 %3,293 / 5,054

62.2 %3,388 / 5,445

61.6 %3,380 / 5,491

61.5 %3,412 / 5,551

58.2 %3,311 / 5,689

59.6 %3,003 / 5,040

64.8 %2,939 / 4,537

61.6 %2,973 / 4,830

64.4 %2,984 / 4,633

61.4 %2,966 / 4,834

55.3 %2,843 / 5,138

53.4 %2,727 / 5,105

66.0 %3,115 / 4,723

3.9 %154 / 3,900

91.9 %3,774 / 4,108

95.6 %3,832 / 4,007

81.5 %3,566 / 4,373

81.2 %3,470 / 4,271

84.3 %3,616 / 4,287

83.6 %3,573 / 4,274

77.3 %3,543 / 4,584

75.4 %3,470 / 4,603

67.6 %3,387 / 5,009

69.9 %3,440 / 4,919

73.0 %3,536 / 4,847

68.6 %3,461 / 5,045

61.2 %3,243 / 5,296

67.9 %3,481 / 5,124

65.2 %3,372 / 5,174

67.3 %3,493 / 5,188

71.4 %3,602 / 5,048

68.5 %3,517 / 5,137

63.2 %3,432 / 5,431

60.2 %3,398 / 5,641

66.8 %3,364 / 5,033

64.1 %3,465 / 5,409

63.1 %3,446 / 5,464

63.1 %3,486 / 5,522

59.8 %3,381 / 5,658

60.9 %3,067 / 5,033

66.6 %2,998 / 4,504

63.1 %3,025 / 4,797

66.1 %3,040 / 4,598

62.9 %3,020 / 4,804

56.5 %2,887 / 5,113

54.5 %2,771 / 5,087

67.7 %3,173 / 4,684

4.3 %168 / 3,946

88.4 %3,717 / 4,203

81.4 %3,598 / 4,422

80.4 %3,484 / 4,334

83.3 %3,628 / 4,353

83.7 %3,610 / 4,312

77.5 %3,584 / 4,623

76.1 %3,520 / 4,628

67.5 %3,416 / 5,062

69.6 %3,467 / 4,979

73.0 %3,570 / 4,890

68.2 %3,485 / 5,108

60.8 %3,261 / 5,363

69.3 %3,530 / 5,091

65.0 %3,398 / 5,231

68.1 %3,552 / 5,217

71.6 %3,645 / 5,091

68.5 %3,549 / 5,179

63.6 %3,478 / 5,467

60.7 %3,447 / 5,680

66.6 %3,388 / 5,087

63.6 %3,489 / 5,484

63.4 %3,494 / 5,514

62.8 %3,509 / 5,591

61.9 %3,454 / 5,578

61.1 %3,101 / 5,078

65.0 %3,004 / 4,620

62.5 %3,052 / 4,884

65.7 %3,077 / 4,682

61.4 %3,037 / 4,943

56.7 %2,939 / 5,186

53.4 %2,782 / 5,211

66.9 %3,201 / 4,782

4.2 %165 / 3,936

81.5 %3,580 / 4,393

81.3 %3,490 / 4,291

84.7 %3,644 / 4,304

84.0 %3,602 / 4,288

76.5 %3,548 / 4,639

75.7 %3,495 / 4,617

67.4 %3,394 / 5,033

69.2 %3,442 / 4,976

72.1 %3,538 / 4,909

68.2 %3,472 / 5,093

61.1 %3,258 / 5,334

68.7 %3,516 / 5,115

65.2 %3,389 / 5,201

67.9 %3,522 / 5,190

70.4 %3,605 / 5,124

67.7 %3,529 / 5,209

62.6 %3,433 / 5,488

60.2 %3,412 / 5,668

66.5 %3,375 / 5,076

62.6 %3,462 / 5,530

62.1 %3,456 / 5,567

62.0 %3,485 / 5,619

58.8 %3,392 / 5,773

60.6 %3,074 / 5,073

66.4 %3,014 / 4,536

62.9 %3,041 / 4,834

65.5 %3,045 / 4,647

62.7 %3,034 / 4,836

55.8 %2,891 / 5,178

54.5 %2,786 / 5,114

67.1 %3,175 / 4,731

3.9 %156 / 3,977

80.9 %3,497 / 4,322

83.3 %3,629 / 4,359

83.5 %3,606 / 4,320

79.4 %3,618 / 4,559

77.6 %3,572 / 4,606

67.5 %3,404 / 5,043

68.9 %3,469 / 5,034

74.7 %3,622 / 4,851

68.0 %3,477 / 5,116

60.4 %3,261 / 5,400

69.9 %3,575 / 5,111

64.7 %3,398 / 5,252

68.6 %3,564 / 5,197

72.2 %3,662 / 5,073

69.2 %3,582 / 5,177

62.5 %3,444 / 5,512

60.8 %3,446 / 5,665

67.4 %3,408 / 5,054

64.8 %3,534 / 5,451

64.3 %3,531 / 5,492

64.3 %3,556 / 5,534

61.5 %3,474 / 5,651

62.0 %3,126 / 5,045

63.8 %3,038 / 4,761

61.3 %3,088 / 5,034

65.1 %3,088 / 4,740

62.5 %3,070 / 4,910

55.9 %2,946 / 5,267

51.8 %2,803 / 5,413

66.4 %3,228 / 4,862

6.4 %242 / 3,797

93.1 %3,742 / 4,020

91.5 %3,685 / 4,027

76.0 %3,467 / 4,564

72.7 %3,385 / 4,653

65.5 %3,277 / 5,004

66.3 %3,317 / 5,006

71.7 %3,479 / 4,855

65.2 %3,337 / 5,116

58.2 %3,126 / 5,375

66.0 %3,383 / 5,128

61.9 %3,257 / 5,258

66.5 %3,428 / 5,157

70.0 %3,535 / 5,050

66.6 %3,435 / 5,157

60.4 %3,318 / 5,496

57.9 %3,288 / 5,681

64.2 %3,254 / 5,069

61.8 %3,390 / 5,488

60.8 %3,378 / 5,552

61.5 %3,416 / 5,557

57.7 %3,306 / 5,733

60.4 %3,026 / 5,007

65.0 %2,945 / 4,532

61.6 %2,984 / 4,841

64.4 %2,991 / 4,645

60.5 %2,934 / 4,847

54.6 %2,827 / 5,176

53.0 %2,740 / 5,167

65.1 %3,116 / 4,787

4.3 %170 / 3,965

95.3 %3,843 / 4,034

78.3 %3,604 / 4,605

75.7 %3,531 / 4,664

67.3 %3,401 / 5,050

68.9 %3,455 / 5,017

74.0 %3,618 / 4,889

67.7 %3,476 / 5,131

60.6 %3,262 / 5,380

68.7 %3,526 / 5,136

63.8 %3,375 / 5,293

68.9 %3,566 / 5,174

72.6 %3,680 / 5,068

69.3 %3,588 / 5,176

62.7 %3,455 / 5,514

59.6 %3,408 / 5,716

66.1 %3,376 / 5,111

64.1 %3,537 / 5,521

63.1 %3,519 / 5,581

63.7 %3,559 / 5,587

59.6 %3,440 / 5,774

62.0 %3,139 / 5,062

66.3 %3,046 / 4,593

63.0 %3,086 / 4,900

66.0 %3,098 / 4,691

62.1 %3,047 / 4,909

55.9 %2,923 / 5,231

53.8 %2,818 / 5,234

66.5 %3,224 / 4,849

4.3 %167 / 3,912

78.5 %3,580 / 4,560

75.8 %3,508 / 4,628

67.8 %3,389 / 5,000

68.7 %3,435 / 4,997

73.6 %3,584 / 4,867

67.9 %3,460 / 5,093

60.7 %3,245 / 5,348

68.9 %3,513 / 5,099

64.0 %3,361 / 5,254

68.8 %3,542 / 5,149

72.0 %3,643 / 5,057

68.9 %3,556 / 5,162

63.0 %3,443 / 5,463

60.0 %3,399 / 5,669

66.9 %3,375 / 5,046

63.4 %3,494 / 5,512

62.7 %3,489 / 5,564

63.1 %3,519 / 5,577

59.7 %3,427 / 5,736

62.6 %3,129 / 5,000

66.1 %3,025 / 4,576

62.7 %3,065 / 4,885

66.0 %3,078 / 4,664

62.0 %3,026 / 4,880

55.8 %2,912 / 5,221

53.7 %2,801 / 5,213

66.6 %3,204 / 4,812

4.0 %165 / 4,142

74.6 %3,578 / 4,799

67.2 %3,460 / 5,151

68.2 %3,515 / 5,157

79.5 %3,828 / 4,816

67.1 %3,521 / 5,250

59.0 %3,273 / 5,544

67.4 %3,583 / 5,313

64.0 %3,453 / 5,398

71.2 %3,718 / 5,225

75.8 %3,821 / 5,040

70.6 %3,690 / 5,227

62.4 %3,500 / 5,610

58.8 %3,437 / 5,842

66.4 %3,437 / 5,175

64.5 %3,578 / 5,546

64.4 %3,590 / 5,577

64.2 %3,612 / 5,623

61.7 %3,532 / 5,720

61.5 %3,179 / 5,170

60.7 %3,062 / 5,047

58.2 %3,107 / 5,342

62.3 %3,126 / 5,020

58.1 %3,069 / 5,283

53.4 %2,983 / 5,588

48.7 %2,825 / 5,795

63.2 %3,285 / 5,198

3.3 %138 / 4,121

64.0 %3,378 / 5,275

64.4 %3,399 / 5,281

70.4 %3,581 / 5,087

64.9 %3,462 / 5,334

57.7 %3,232 / 5,601

65.8 %3,527 / 5,361

60.9 %3,347 / 5,499

70.8 %3,682 / 5,201

69.9 %3,671 / 5,250

63.1 %3,475 / 5,504

61.5 %3,484 / 5,661

58.5 %3,439 / 5,876

62.4 %3,336 / 5,344

59.1 %3,425 / 5,796

60.0 %3,475 / 5,788

58.9 %3,458 / 5,867

57.2 %3,417 / 5,977

58.5 %3,086 / 5,276

61.1 %2,987 / 4,891

58.3 %3,030 / 5,200

61.2 %3,044 / 4,977

58.4 %3,014 / 5,163

54.3 %2,928 / 5,389

49.8 %2,766 / 5,554

61.4 %3,169 / 5,164

4.4 %191 / 4,327

68.1 %3,518 / 5,165

65.7 %3,518 / 5,356

73.3 %3,776 / 5,148

66.4 %3,592 / 5,406

65.4 %3,568 / 5,458

67.3 %3,633 / 5,396

61.3 %3,468 / 5,656

62.4 %3,518 / 5,638

63.5 %3,532 / 5,563

74.1 %3,939 / 5,313

71.0 %3,869 / 5,448

67.1 %3,527 / 5,259

57.7 %3,416 / 5,921

57.6 %3,426 / 5,951

57.5 %3,440 / 5,982

55.1 %3,372 / 6,121

56.9 %3,124 / 5,488

55.9 %2,964 / 5,299

54.3 %3,009 / 5,538

56.2 %3,002 / 5,345

54.6 %2,969 / 5,433

50.7 %2,898 / 5,716

47.2 %2,796 / 5,919

56.1 %3,126 / 5,572

5.6 %236 / 4,244

67.7 %3,578 / 5,285

68.9 %3,617 / 5,251

62.7 %3,428 / 5,471

69.8 %3,695 / 5,291

65.0 %3,515 / 5,409

61.0 %3,470 / 5,685

63.2 %3,547 / 5,611

68.3 %3,677 / 5,385

64.4 %3,613 / 5,608

61.9 %3,558 / 5,749

64.3 %3,449 / 5,364

60.6 %3,518 / 5,809

60.2 %3,515 / 5,838

60.2 %3,542 / 5,887

57.8 %3,462 / 5,991

57.0 %3,136 / 5,500

61.1 %2,994 / 4,898

59.5 %3,045 / 5,121

61.5 %3,060 / 4,973

59.0 %3,020 / 5,122

52.9 %2,911 / 5,500

50.4 %2,803 / 5,556

62.0 %3,160 / 5,098

5.3 %230 / 4,376

67.9 %3,635 / 5,352

59.5 %3,386 / 5,687

65.2 %3,605 / 5,527

65.7 %3,574 / 5,444

69.5 %3,741 / 5,385

72.2 %3,839 / 5,319

69.2 %3,734 / 5,393

63.2 %3,618 / 5,728

59.3 %3,530 / 5,951

64.2 %3,476 / 5,418

64.9 %3,656 / 5,635

64.9 %3,659 / 5,640

64.4 %3,682 / 5,720

61.8 %3,593 / 5,814

58.0 %3,184 / 5,488

61.0 %3,077 / 5,044

59.6 %3,137 / 5,266

61.1 %3,143 / 5,140

58.0 %3,092 / 5,333

54.7 %3,001 / 5,491

52.1 %2,838 / 5,444

62.4 %3,284 / 5,263

5.2 %233 / 4,485

76.6 %3,926 / 5,127

67.0 %3,695 / 5,511

72.4 %3,812 / 5,265

61.3 %3,532 / 5,764

62.4 %3,573 / 5,724

68.6 %3,759 / 5,480

77.2 %4,088 / 5,295

69.7 %3,888 / 5,582

68.9 %3,650 / 5,299

59.5 %3,512 / 5,901

60.3 %3,545 / 5,880

58.9 %3,527 / 5,990

57.7 %3,487 / 6,041

58.7 %3,238 / 5,518

57.8 %2,997 / 5,183

56.1 %3,043 / 5,426

57.7 %3,053 / 5,293

57.3 %3,051 / 5,329

53.2 %2,966 / 5,571

51.3 %2,826 / 5,513

58.6 %3,193 / 5,446

5.3 %238 / 4,526

61.5 %3,510 / 5,706

62.8 %3,537 / 5,629

55.3 %3,328 / 6,013

57.0 %3,396 / 5,954

59.7 %3,483 / 5,830

70.8 %3,920 / 5,540

62.9 %3,685 / 5,862

62.5 %3,468 / 5,552

54.4 %3,337 / 6,130

54.7 %3,351 / 6,123

54.2 %3,358 / 6,194

52.3 %3,291 / 6,294

52.9 %3,045 / 5,752

52.8 %2,843 / 5,382

51.3 %2,891 / 5,633

53.1 %2,901 / 5,459

51.6 %2,868 / 5,562

48.2 %2,785 / 5,784

45.8 %2,650 / 5,781

53.0 %3,008 / 5,672

5.1 %232 / 4,551

62.0 %3,540 / 5,714

64.3 %3,654 / 5,679

64.6 %3,694 / 5,717

67.6 %3,794 / 5,609

63.9 %3,729 / 5,835

61.0 %3,660 / 6,000

63.9 %3,558 / 5,564

61.0 %3,635 / 5,960

62.0 %3,686 / 5,943

61.0 %3,657 / 5,998

63.0 %3,722 / 5,905

55.4 %3,163 / 5,710

58.5 %3,049 / 5,208

57.2 %3,111 / 5,435

59.0 %3,122 / 5,291

57.2 %3,081 / 5,389

53.8 %3,025 / 5,623

49.3 %2,870 / 5,818

59.3 %3,234 / 5,452

6.0 %268 / 4,451

58.1 %3,429 / 5,898

59.7 %3,493 / 5,854

63.4 %3,600 / 5,678

65.2 %3,741 / 5,742

64.0 %3,732 / 5,835

65.0 %3,548 / 5,458

60.0 %3,496 / 5,822

59.7 %3,496 / 5,853

59.2 %3,507 / 5,924

57.0 %3,439 / 6,035

54.7 %3,124 / 5,707

56.6 %2,973 / 5,254

54.6 %3,015 / 5,518

55.3 %2,991 / 5,407

55.4 %3,019 / 5,449

52.3 %2,936 / 5,609

50.1 %2,789 / 5,563

57.2 %3,140 / 5,493

5.0 %232 / 4,605

71.1 %3,902 / 5,490

62.6 %3,630 / 5,803

59.5 %3,585 / 6,024

56.7 %3,535 / 6,231

59.4 %3,425 / 5,763

59.0 %3,579 / 6,067

60.0 %3,624 / 6,039

58.9 %3,605 / 6,124

58.3 %3,599 / 6,176

53.7 %3,131 / 5,827

57.8 %3,038 / 5,257

56.7 %3,106 / 5,474

58.0 %3,109 / 5,356

55.3 %3,044 / 5,509

53.0 %3,019 / 5,698

51.0 %2,836 / 5,566

60.7 %3,275 / 5,392

5.2 %241 / 4,663

64.9 %3,714 / 5,725

61.3 %3,665 / 5,975

56.8 %3,549 / 6,249

62.0 %3,511 / 5,662

63.6 %3,729 / 5,861

63.0 %3,715 / 5,900

62.6 %3,733 / 5,959

60.4 %3,657 / 6,058

55.7 %3,201 / 5,745

59.5 %3,115 / 5,238

58.5 %3,190 / 5,455

59.8 %3,180 / 5,315

58.1 %3,140 / 5,407

54.1 %3,070 / 5,678

50.8 %2,865 / 5,642

61.1 %3,332 / 5,451

5.0 %236 / 4,676

63.8 %3,746 / 5,875

59.1 %3,608 / 6,107

62.4 %3,521 / 5,647

62.9 %3,706 / 5,889

62.8 %3,708 / 5,902

62.8 %3,739 / 5,958

60.2 %3,651 / 6,061

58.0 %3,281 / 5,653

59.2 %3,081 / 5,205

58.4 %3,158 / 5,408

59.5 %3,144 / 5,286

56.0 %3,073 / 5,486

53.1 %3,014 / 5,679

49.6 %2,886 / 5,817

62.2 %3,308 / 5,316

4.8 %232 / 4,866

73.7 %4,167 / 5,651

65.7 %3,686 / 5,607

57.6 %3,574 / 6,200

57.5 %3,579 / 6,224

57.1 %3,588 / 6,283

55.5 %3,534 / 6,367

55.2 %3,237 / 5,869

54.0 %3,014 / 5,577

52.6 %3,068 / 5,835

53.7 %3,055 / 5,686

53.6 %3,066 / 5,716

50.8 %3,008 / 5,922

48.3 %2,844 / 5,894

55.3 %3,202 / 5,789

5.3 %261 / 4,913

61.1 %3,578 / 5,853

53.8 %3,468 / 6,443

54.1 %3,491 / 6,452

53.7 %3,488 / 6,497

53.0 %3,481 / 6,567

51.1 %3,145 / 6,154

52.2 %2,982 / 5,710

51.4 %3,042 / 5,915

52.4 %3,012 / 5,749

52.2 %3,027 / 5,800

49.0 %2,970 / 6,061

45.2 %2,793 / 6,182

53.6 %3,134 / 5,850

5.0 %218 / 4,327

62.5 %3,541 / 5,668

62.6 %3,542 / 5,659

61.9 %3,550 / 5,736

59.4 %3,476 / 5,850

57.0 %3,124 / 5,485

55.8 %2,980 / 5,336

54.1 %3,022 / 5,583

56.0 %3,001 / 5,357

55.6 %3,036 / 5,464

51.2 %2,933 / 5,728

49.0 %2,804 / 5,723

55.5 %3,127 / 5,639

6.5 %307 / 4,692

85.4 %4,339 / 5,078

87.3 %4,416 / 5,061

78.2 %4,178 / 5,341

51.8 %3,134 / 6,054

56.6 %3,075 / 5,430

55.7 %3,147 / 5,652

56.5 %3,128 / 5,535

55.1 %3,089 / 5,606

51.0 %2,977 / 5,839

51.1 %2,938 / 5,747

58.3 %3,258 / 5,585

6.8 %320 / 4,711

86.6 %4,398 / 5,077

84.5 %4,359 / 5,158

51.6 %3,139 / 6,084

55.2 %3,038 / 5,508

54.6 %3,121 / 5,713

55.5 %3,107 / 5,595

54.5 %3,081 / 5,650

51.1 %2,993 / 5,860

50.5 %2,917 / 5,779

57.7 %3,247 / 5,632

7.8 %371 / 4,729

77.1 %4,173 / 5,409

51.2 %3,146 / 6,142

55.3 %3,098 / 5,599

54.6 %3,168 / 5,797

56.0 %3,142 / 5,614

54.7 %3,103 / 5,671

50.3 %2,985 / 5,934

49.5 %2,951 / 5,956

58.1 %3,286 / 5,652

7.4 %348 / 4,686

50.0 %3,105 / 6,216

51.9 %2,991 / 5,767

51.5 %3,068 / 5,962

53.7 %3,076 / 5,729

52.2 %3,036 / 5,812

51.1 %3,027 / 5,918

44.8 %2,865 / 6,398

55.0 %3,192 / 5,801

3.7 %151 / 4,136

53.8 %2,755 / 5,124

51.7 %2,797 / 5,408

54.4 %2,822 / 5,187

51.6 %2,768 / 5,364

47.5 %2,702 / 5,686

46.2 %2,618 / 5,672

54.3 %2,915 / 5,371

4.0 %138 / 3,449

84.5 %3,283 / 3,886

81.1 %3,153 / 3,890

63.8 %2,813 / 4,411

58.4 %2,733 / 4,677

59.9 %2,635 / 4,396

66.0 %2,921 / 4,428

5.1 %187 / 3,663

80.1 %3,211 / 4,009

65.0 %2,884 / 4,434

60.8 %2,856 / 4,696

61.1 %2,758 / 4,512

67.7 %3,051 / 4,508

4.6 %160 / 3,501

67.0 %2,837 / 4,237

60.4 %2,778 / 4,597

59.0 %2,667 / 4,524

66.8 %2,993 / 4,481

3.6 %126 / 3,472

68.5 %2,981 / 4,350

57.9 %2,698 / 4,656

68.0 %3,011 / 4,427

4.5 %168 / 3,700

53.8 %2,692 / 5,007

61.6 %2,951 / 4,791

3.4 %115 / 3,371

61.9 %2,837 / 4,581

4.6 %171 / 3,727

Escherichia coli

strain BW2952




Escherichia coli



Escherichia coli


I


Escherichia coli

B strain REL606


Escherichia coli

strain ATCC 8739


Escherichia coli


10B


Escherichia coli



Escherichia coli


1655



I1



S





I39






Escherichia coli

strain APEC O

1


Escherichia coli

strain SMS-3-5



1a


Escherichia coli

strain E24377A




Escherichia coli

strain UM

N026


Escherichia coli

strain UTI89


Escherichia coli

strain CFT073


Escherichia coli

serotype O127:H

6 strain E2348/69


Escherichia coli

serotype O157:H

7 strain Sakai


Escherichia coli

serotype O157:H

7 strain TW14359


Escherichia coli

serotype O157:H

7 strain EDL933


Escherichia coli

serotype O157:H

7 strain EC4115



strain ATCC 35469


Shigella flexneri

2a strain 2457T


Shigella flexneri

2a strain 301


Shigella flexneri

5 strain 8401




Shigella boydii

strain CDC 3083-94






Esche

richi

a coli

stra

in B

W29

52

4,08

4 pro

tein

s, 3,

817

fam

ilies

Esche

richi

a coli

stra

in B

L21

4,08

7 pro

tein

s, 3,

833

fam

ilies

Esche

richi

a coli

stra

in B

L21(D

E3) -

Korea

Res IB

B

4,15

3 pro

tein

s, 3,

900

fam

ilies

Esche

richi

a coli

stra

in B

L21(D

E3) -

JGI

4,22

8 pro

tein

s, 3,

946

fam

ilies

Esche

richi

a coli

B stra

in R

EL606

4,20

5 pro

tein

s, 3,

936

fam

ilies

Esche

richi

a coli

stra

in A

TCC 873

9

4,20

0 pro

tein

s, 3,

977

fam

ilies

Esche

richi

a coli

stra

in K

-12,

subst

rain

DH

10B

4,12

6 pro

tein

s, 3,

797

fam

ilies

Esche

richi

a coli

stra

in K

-12,

subst

rain

W31

10

4,22

6 pro

tein

s, 3,

965

fam

ilies

Esche

richi

a coli

stra

in K

-12,

subst

rain

MG

1655

4,15

0 pro

tein

s, 3,

912

fam

ilies

Esche

richi

a coli

stra

in IA

I1

4,35

3 pro

tein

s, 4,

142

fam

ilies

Esche

richi

a coli

stra

in H

S

4,37

8 pro

tein

s, 4,

121

fam

ilies

Esche

richi

a coli

stra

in 5

36

4,62

0 pro

tein

s, 4,

327

fam

ilies

Esche

richi

a coli

stra

in IA

I39

4,73

2 pro

tein

s, 4,

244

fam

ilies

Esche

richi

a coli

stra

in 5

5989

4,76

3 pro

tein

s, 4,

376

fam

ilies

Esche

richi

a coli

stra

in S

88

4,83

2 pro

tein

s, 4,

485

fam

ilies

Esche

richi

a coli

stra

in A

PEC O1

4,85

1 pro

tein

s, 4,

526

fam

ilies

Esche

richi

a coli

stra

in S

MS-

3-5

4,91

3 pro

tein

s, 4,

551

fam

ilies

Esche

richi

a coli

stra

in E

D1a

4,91

5 pro

tein

s, 4,

451

fam

ilies

Esche

richi

a coli

stra

in E

2437

7A

4,99

1 pro

tein

s, 4,

605

fam

ilies

Esche

richi

a coli

stra

in S

E11

5,00

2 pro

tein

s, 4,

663

fam

ilies

Esche

richi

a coli

stra

in U

MN

026

5,01

7 pro

tein

s, 4,

676

fam

ilies

Esche

richi

a coli

stra

in U

TI89

5,16

6 pro

tein

s, 4,

866

fam

ilies

Esche

richi

a coli

stra

in C

FT073

5,33

9 pro

tein

s, 4,

913

fam

ilies

Esche

richi

a coli

sero

type O

127:

H6

stra

in E

2348

/69

4,65

3 pro

tein

s, 4,

327

fam

ilies

Esche

richi

a coli

sero

type O

157:

H7

stra

in S

akai

5,31

8 pro

tein

s, 4,

692

fam

ilies

Esche

richi

a coli

sero

type O

157:

H7

stra

in T

W14

359

5,37

2 pro

tein

s, 4,

711

fam

ilies

Esche

richi

a coli

sero

type O

157:

H7

stra

in E

DL93

3

5,41

1 pro

tein

s, 4,

729

fam

ilies

Esche

richi

a coli

sero

type O

157:

H7

stra

in E

C4115

5,47

7 pro

tein

s, 4,

686

fam

ilies

Esche

richi

a fer

guso

nii

stra

in A

TCC 354

69

4,32

1 pro

tein

s, 4,

136

fam

ilies

Shige

lla fl

exner

i

2a st

rain

245

7T

4,06

1 pro

tein

s, 3,

449

fam

ilies

Shige

lla fl

exner

i

2a st

rain

301

4,44

0 pro

tein

s, 3,

663

fam

ilies

Shige

lla fl

exner

i

5 st

rain

840

1

4,11

5 pro

tein

s, 3,

501

fam

ilies

Shige

lla bo

ydii

stra

in S

b227

4,28

2 pro

tein

s, 3,

472

fam

ilies

Shige

lla bo

ydii

stra

in C

DC 3

083-

94

4,55

7 pro

tein

s, 3,

700

fam

ilies

Shige

lla d

ysen

teriae

stra

in S

d197

4,50

2 pro

tein

s, 3,

371

fam

ilies

Shige

lla so

nnei

stra

in S

s046

4,47

1 pro

tein

s, 3,

727

fam

ilies

Homology within proteomes

20.0 %0.0 %

Homology between proteomes

100.0 %40.0 %

4.7 %180 / 3,817

80.8 %3,461 / 4,283

83.3 %3,537 / 4,247

83.7 %3,555 / 4,249

82.3 %3,534 / 4,293

82.8 %3,562 / 4,301

90.6 %3,635 / 4,010

92.2 %3,748 / 4,064

95.2 %3,784 / 3,974

78.3 %3,541 / 4,521

74.8 %3,458 / 4,620

67.6 %3,360 / 4,967

68.6 %3,392 / 4,947

73.5 %3,540 / 4,817

68.3 %3,428 / 5,021

60.8 %3,213 / 5,287

68.3 %3,440 / 5,039

64.3 %3,340 / 5,191

67.7 %3,481 / 5,144

72.0 %3,597 / 4,999

69.1 %3,517 / 5,088

63.1 %3,412 / 5,407

60.3 %3,374 / 5,595

66.9 %3,347 / 5,002

64.0 %3,461 / 5,408

63.2 %3,452 / 5,458

63.5 %3,484 / 5,487

61.5 %3,387 / 5,503

62.6 %3,109 / 4,963

67.1 %3,027 / 4,511

63.7 %3,065 / 4,814

67.0 %3,079 / 4,595

62.6 %3,015 / 4,818

56.8 %2,912 / 5,130

54.3 %2,797 / 5,155

67.2 %3,191 / 4,749

4.0 %154 / 3,833

93.6 %3,742 / 4,000

89.1 %3,686 / 4,138

90.2 %3,691 / 4,093

79.5 %3,491 / 4,393

79.3 %3,403 / 4,294

82.3 %3,550 / 4,313

81.0 %3,493 / 4,310

75.4 %3,472 / 4,606

73.8 %3,403 / 4,614

66.2 %3,326 / 5,023

68.3 %3,372 / 4,934

71.0 %3,461 / 4,878

66.9 %3,387 / 5,066

59.7 %3,174 / 5,314

66.2 %3,409 / 5,153

63.6 %3,305 / 5,196

65.8 %3,429 / 5,209

69.6 %3,529 / 5,070

66.7 %3,439 / 5,159

61.8 %3,366 / 5,446

58.8 %3,332 / 5,667

65.2 %3,293 / 5,054

62.2 %3,388 / 5,445

61.6 %3,380 / 5,491

61.5 %3,412 / 5,551

58.2 %3,311 / 5,689

59.6 %3,003 / 5,040

64.8 %2,939 / 4,537

61.6 %2,973 / 4,830

64.4 %2,984 / 4,633

61.4 %2,966 / 4,834

55.3 %2,843 / 5,138

53.4 %2,727 / 5,105

66.0 %3,115 / 4,723

3.9 %154 / 3,900

91.9 %3,774 / 4,108

95.6 %3,832 / 4,007

81.5 %3,566 / 4,373

81.2 %3,470 / 4,271

84.3 %3,616 / 4,287

83.6 %3,573 / 4,274

77.3 %3,543 / 4,584

75.4 %3,470 / 4,603

67.6 %3,387 / 5,009

69.9 %3,440 / 4,919

73.0 %3,536 / 4,847

68.6 %3,461 / 5,045

61.2 %3,243 / 5,296

67.9 %3,481 / 5,124

65.2 %3,372 / 5,174

67.3 %3,493 / 5,188

71.4 %3,602 / 5,048

68.5 %3,517 / 5,137

63.2 %3,432 / 5,431

60.2 %3,398 / 5,641

66.8 %3,364 / 5,033

64.1 %3,465 / 5,409

63.1 %3,446 / 5,464

63.1 %3,486 / 5,522

59.8 %3,381 / 5,658

60.9 %3,067 / 5,033

66.6 %2,998 / 4,504

63.1 %3,025 / 4,797

66.1 %3,040 / 4,598

62.9 %3,020 / 4,804

56.5 %2,887 / 5,113

54.5 %2,771 / 5,087

67.7 %3,173 / 4,684

4.3 %168 / 3,946

88.4 %3,717 / 4,203

81.4 %3,598 / 4,422

80.4 %3,484 / 4,334

83.3 %3,628 / 4,353

83.7 %3,610 / 4,312

77.5 %3,584 / 4,623

76.1 %3,520 / 4,628

67.5 %3,416 / 5,062

69.6 %3,467 / 4,979

73.0 %3,570 / 4,890

68.2 %3,485 / 5,108

60.8 %3,261 / 5,363

69.3 %3,530 / 5,091

65.0 %3,398 / 5,231

68.1 %3,552 / 5,217

71.6 %3,645 / 5,091

68.5 %3,549 / 5,179

63.6 %3,478 / 5,467

60.7 %3,447 / 5,680

66.6 %3,388 / 5,087

63.6 %3,489 / 5,484

63.4 %3,494 / 5,514

62.8 %3,509 / 5,591

61.9 %3,454 / 5,578

61.1 %3,101 / 5,078

65.0 %3,004 / 4,620

62.5 %3,052 / 4,884

65.7 %3,077 / 4,682

61.4 %3,037 / 4,943

56.7 %2,939 / 5,186

53.4 %2,782 / 5,211

66.9 %3,201 / 4,782

4.2 %165 / 3,936

81.5 %3,580 / 4,393

81.3 %3,490 / 4,291

84.7 %3,644 / 4,304

84.0 %3,602 / 4,288

76.5 %3,548 / 4,639

75.7 %3,495 / 4,617

67.4 %3,394 / 5,033

69.2 %3,442 / 4,976

72.1 %3,538 / 4,909

68.2 %3,472 / 5,093

61.1 %3,258 / 5,334

68.7 %3,516 / 5,115

65.2 %3,389 / 5,201

67.9 %3,522 / 5,190

70.4 %3,605 / 5,124

67.7 %3,529 / 5,209

62.6 %3,433 / 5,488

60.2 %3,412 / 5,668

66.5 %3,375 / 5,076

62.6 %3,462 / 5,530

62.1 %3,456 / 5,567

62.0 %3,485 / 5,619

58.8 %3,392 / 5,773

60.6 %3,074 / 5,073

66.4 %3,014 / 4,536

62.9 %3,041 / 4,834

65.5 %3,045 / 4,647

62.7 %3,034 / 4,836

55.8 %2,891 / 5,178

54.5 %2,786 / 5,114

67.1 %3,175 / 4,731

3.9 %156 / 3,977

80.9 %3,497 / 4,322

83.3 %3,629 / 4,359

83.5 %3,606 / 4,320

79.4 %3,618 / 4,559

77.6 %3,572 / 4,606

67.5 %3,404 / 5,043

68.9 %3,469 / 5,034

74.7 %3,622 / 4,851

68.0 %3,477 / 5,116

60.4 %3,261 / 5,400

69.9 %3,575 / 5,111

64.7 %3,398 / 5,252

68.6 %3,564 / 5,197

72.2 %3,662 / 5,073

69.2 %3,582 / 5,177

62.5 %3,444 / 5,512

60.8 %3,446 / 5,665

67.4 %3,408 / 5,054

64.8 %3,534 / 5,451

64.3 %3,531 / 5,492

64.3 %3,556 / 5,534

61.5 %3,474 / 5,651

62.0 %3,126 / 5,045

63.8 %3,038 / 4,761

61.3 %3,088 / 5,034

65.1 %3,088 / 4,740

62.5 %3,070 / 4,910

55.9 %2,946 / 5,267

51.8 %2,803 / 5,413

66.4 %3,228 / 4,862

6.4 %242 / 3,797

93.1 %3,742 / 4,020

91.5 %3,685 / 4,027

76.0 %3,467 / 4,564

72.7 %3,385 / 4,653

65.5 %3,277 / 5,004

66.3 %3,317 / 5,006

71.7 %3,479 / 4,855

65.2 %3,337 / 5,116

58.2 %3,126 / 5,375

66.0 %3,383 / 5,128

61.9 %3,257 / 5,258

66.5 %3,428 / 5,157

70.0 %3,535 / 5,050

66.6 %3,435 / 5,157

60.4 %3,318 / 5,496

57.9 %3,288 / 5,681

64.2 %3,254 / 5,069

61.8 %3,390 / 5,488

60.8 %3,378 / 5,552

61.5 %3,416 / 5,557

57.7 %3,306 / 5,733

60.4 %3,026 / 5,007

65.0 %2,945 / 4,532

61.6 %2,984 / 4,841

64.4 %2,991 / 4,645

60.5 %2,934 / 4,847

54.6 %2,827 / 5,176

53.0 %2,740 / 5,167

65.1 %3,116 / 4,787

4.3 %170 / 3,965

95.3 %3,843 / 4,034

78.3 %3,604 / 4,605

75.7 %3,531 / 4,664

67.3 %3,401 / 5,050

68.9 %3,455 / 5,017

74.0 %3,618 / 4,889

67.7 %3,476 / 5,131

60.6 %3,262 / 5,380

68.7 %3,526 / 5,136

63.8 %3,375 / 5,293

68.9 %3,566 / 5,174

72.6 %3,680 / 5,068

69.3 %3,588 / 5,176

62.7 %3,455 / 5,514

59.6 %3,408 / 5,716

66.1 %3,376 / 5,111

64.1 %3,537 / 5,521

63.1 %3,519 / 5,581

63.7 %3,559 / 5,587

59.6 %3,440 / 5,774

62.0 %3,139 / 5,062

66.3 %3,046 / 4,593

63.0 %3,086 / 4,900

66.0 %3,098 / 4,691

62.1 %3,047 / 4,909

55.9 %2,923 / 5,231

53.8 %2,818 / 5,234

66.5 %3,224 / 4,849

4.3 %167 / 3,912

78.5 %3,580 / 4,560

75.8 %3,508 / 4,628

67.8 %3,389 / 5,000

68.7 %3,435 / 4,997

73.6 %3,584 / 4,867

67.9 %3,460 / 5,093

60.7 %3,245 / 5,348

68.9 %3,513 / 5,099

64.0 %3,361 / 5,254

68.8 %3,542 / 5,149

72.0 %3,643 / 5,057

68.9 %3,556 / 5,162

63.0 %3,443 / 5,463

60.0 %3,399 / 5,669

66.9 %3,375 / 5,046

63.4 %3,494 / 5,512

62.7 %3,489 / 5,564

63.1 %3,519 / 5,577

59.7 %3,427 / 5,736

62.6 %3,129 / 5,000

66.1 %3,025 / 4,576

62.7 %3,065 / 4,885

66.0 %3,078 / 4,664

62.0 %3,026 / 4,880

55.8 %2,912 / 5,221

53.7 %2,801 / 5,213

66.6 %3,204 / 4,812

4.0 %165 / 4,142

74.6 %3,578 / 4,799

67.2 %3,460 / 5,151

68.2 %3,515 / 5,157

79.5 %3,828 / 4,816

67.1 %3,521 / 5,250

59.0 %3,273 / 5,544

67.4 %3,583 / 5,313

64.0 %3,453 / 5,398

71.2 %3,718 / 5,225

75.8 %3,821 / 5,040

70.6 %3,690 / 5,227

62.4 %3,500 / 5,610

58.8 %3,437 / 5,842

66.4 %3,437 / 5,175

64.5 %3,578 / 5,546

64.4 %3,590 / 5,577

64.2 %3,612 / 5,623

61.7 %3,532 / 5,720

61.5 %3,179 / 5,170

60.7 %3,062 / 5,047

58.2 %3,107 / 5,342

62.3 %3,126 / 5,020

58.1 %3,069 / 5,283

53.4 %2,983 / 5,588

48.7 %2,825 / 5,795

63.2 %3,285 / 5,198

3.3 %138 / 4,121

64.0 %3,378 / 5,275

64.4 %3,399 / 5,281

70.4 %3,581 / 5,087

64.9 %3,462 / 5,334

57.7 %3,232 / 5,601

65.8 %3,527 / 5,361

60.9 %3,347 / 5,499

70.8 %3,682 / 5,201

69.9 %3,671 / 5,250

63.1 %3,475 / 5,504

61.5 %3,484 / 5,661

58.5 %3,439 / 5,876

62.4 %3,336 / 5,344

59.1 %3,425 / 5,796

60.0 %3,475 / 5,788

58.9 %3,458 / 5,867

57.2 %3,417 / 5,977

58.5 %3,086 / 5,276

61.1 %2,987 / 4,891

58.3 %3,030 / 5,200

61.2 %3,044 / 4,977

58.4 %3,014 / 5,163

54.3 %2,928 / 5,389

49.8 %2,766 / 5,554

61.4 %3,169 / 5,164

4.4 %191 / 4,327

68.1 %3,518 / 5,165

65.7 %3,518 / 5,356

73.3 %3,776 / 5,148

66.4 %3,592 / 5,406

65.4 %3,568 / 5,458

67.3 %3,633 / 5,396

61.3 %3,468 / 5,656

62.4 %3,518 / 5,638

63.5 %3,532 / 5,563

74.1 %3,939 / 5,313

71.0 %3,869 / 5,448

67.1 %3,527 / 5,259

57.7 %3,416 / 5,921

57.6 %3,426 / 5,951

57.5 %3,440 / 5,982

55.1 %3,372 / 6,121

56.9 %3,124 / 5,488

55.9 %2,964 / 5,299

54.3 %3,009 / 5,538

56.2 %3,002 / 5,345

54.6 %2,969 / 5,433

50.7 %2,898 / 5,716

47.2 %2,796 / 5,919

56.1 %3,126 / 5,572

5.6 %236 / 4,244

67.7 %3,578 / 5,285

68.9 %3,617 / 5,251

62.7 %3,428 / 5,471

69.8 %3,695 / 5,291

65.0 %3,515 / 5,409

61.0 %3,470 / 5,685

63.2 %3,547 / 5,611

68.3 %3,677 / 5,385

64.4 %3,613 / 5,608

61.9 %3,558 / 5,749

64.3 %3,449 / 5,364

60.6 %3,518 / 5,809

60.2 %3,515 / 5,838

60.2 %3,542 / 5,887

57.8 %3,462 / 5,991

57.0 %3,136 / 5,500

61.1 %2,994 / 4,898

59.5 %3,045 / 5,121

61.5 %3,060 / 4,973

59.0 %3,020 / 5,122

52.9 %2,911 / 5,500

50.4 %2,803 / 5,556

62.0 %3,160 / 5,098

5.3 %230 / 4,376

67.9 %3,635 / 5,352

59.5 %3,386 / 5,687

65.2 %3,605 / 5,527

65.7 %3,574 / 5,444

69.5 %3,741 / 5,385

72.2 %3,839 / 5,319

69.2 %3,734 / 5,393

63.2 %3,618 / 5,728

59.3 %3,530 / 5,951

64.2 %3,476 / 5,418

64.9 %3,656 / 5,635

64.9 %3,659 / 5,640

64.4 %3,682 / 5,720

61.8 %3,593 / 5,814

58.0 %3,184 / 5,488

61.0 %3,077 / 5,044

59.6 %3,137 / 5,266

61.1 %3,143 / 5,140

58.0 %3,092 / 5,333

54.7 %3,001 / 5,491

52.1 %2,838 / 5,444

62.4 %3,284 / 5,263

5.2 %233 / 4,485

76.6 %3,926 / 5,127

67.0 %3,695 / 5,511

72.4 %3,812 / 5,265

61.3 %3,532 / 5,764

62.4 %3,573 / 5,724

68.6 %3,759 / 5,480

77.2 %4,088 / 5,295

69.7 %3,888 / 5,582

68.9 %3,650 / 5,299

59.5 %3,512 / 5,901

60.3 %3,545 / 5,880

58.9 %3,527 / 5,990

57.7 %3,487 / 6,041

58.7 %3,238 / 5,518

57.8 %2,997 / 5,183

56.1 %3,043 / 5,426

57.7 %3,053 / 5,293

57.3 %3,051 / 5,329

53.2 %2,966 / 5,571

51.3 %2,826 / 5,513

58.6 %3,193 / 5,446

5.3 %238 / 4,526

61.5 %3,510 / 5,706

62.8 %3,537 / 5,629

55.3 %3,328 / 6,013

57.0 %3,396 / 5,954

59.7 %3,483 / 5,830

70.8 %3,920 / 5,540

62.9 %3,685 / 5,862

62.5 %3,468 / 5,552

54.4 %3,337 / 6,130

54.7 %3,351 / 6,123

54.2 %3,358 / 6,194

52.3 %3,291 / 6,294

52.9 %3,045 / 5,752

52.8 %2,843 / 5,382

51.3 %2,891 / 5,633

53.1 %2,901 / 5,459

51.6 %2,868 / 5,562

48.2 %2,785 / 5,784

45.8 %2,650 / 5,781

53.0 %3,008 / 5,672

5.1 %232 / 4,551

62.0 %3,540 / 5,714

64.3 %3,654 / 5,679

64.6 %3,694 / 5,717

67.6 %3,794 / 5,609

63.9 %3,729 / 5,835

61.0 %3,660 / 6,000

63.9 %3,558 / 5,564

61.0 %3,635 / 5,960

62.0 %3,686 / 5,943

61.0 %3,657 / 5,998

63.0 %3,722 / 5,905

55.4 %3,163 / 5,710

58.5 %3,049 / 5,208

57.2 %3,111 / 5,435

59.0 %3,122 / 5,291

57.2 %3,081 / 5,389

53.8 %3,025 / 5,623

49.3 %2,870 / 5,818

59.3 %3,234 / 5,452

6.0 %268 / 4,451

58.1 %3,429 / 5,898

59.7 %3,493 / 5,854

63.4 %3,600 / 5,678

65.2 %3,741 / 5,742

64.0 %3,732 / 5,835

65.0 %3,548 / 5,458

60.0 %3,496 / 5,822

59.7 %3,496 / 5,853

59.2 %3,507 / 5,924

57.0 %3,439 / 6,035

54.7 %3,124 / 5,707

56.6 %2,973 / 5,254

54.6 %3,015 / 5,518

55.3 %2,991 / 5,407

55.4 %3,019 / 5,449

52.3 %2,936 / 5,609

50.1 %2,789 / 5,563

57.2 %3,140 / 5,493

5.0 %232 / 4,605

71.1 %3,902 / 5,490

62.6 %3,630 / 5,803

59.5 %3,585 / 6,024

56.7 %3,535 / 6,231

59.4 %3,425 / 5,763

59.0 %3,579 / 6,067

60.0 %3,624 / 6,039

58.9 %3,605 / 6,124

58.3 %3,599 / 6,176

53.7 %3,131 / 5,827

57.8 %3,038 / 5,257

56.7 %3,106 / 5,474

58.0 %3,109 / 5,356

55.3 %3,044 / 5,509

53.0 %3,019 / 5,698

51.0 %2,836 / 5,566

60.7 %3,275 / 5,392

5.2 %241 / 4,663

64.9 %3,714 / 5,725

61.3 %3,665 / 5,975

56.8 %3,549 / 6,249

62.0 %3,511 / 5,662

63.6 %3,729 / 5,861

63.0 %3,715 / 5,900

62.6 %3,733 / 5,959

60.4 %3,657 / 6,058

55.7 %3,201 / 5,745

59.5 %3,115 / 5,238

58.5 %3,190 / 5,455

59.8 %3,180 / 5,315

58.1 %3,140 / 5,407

54.1 %3,070 / 5,678

50.8 %2,865 / 5,642

61.1 %3,332 / 5,451

5.0 %236 / 4,676

63.8 %3,746 / 5,875

59.1 %3,608 / 6,107

62.4 %3,521 / 5,647

62.9 %3,706 / 5,889

62.8 %3,708 / 5,902

62.8 %3,739 / 5,958

60.2 %3,651 / 6,061

58.0 %3,281 / 5,653

59.2 %3,081 / 5,205

58.4 %3,158 / 5,408

59.5 %3,144 / 5,286

56.0 %3,073 / 5,486

53.1 %3,014 / 5,679

49.6 %2,886 / 5,817

62.2 %3,308 / 5,316

4.8 %232 / 4,866

73.7 %4,167 / 5,651

65.7 %3,686 / 5,607

57.6 %3,574 / 6,200

57.5 %3,579 / 6,224

57.1 %3,588 / 6,283

55.5 %3,534 / 6,367

55.2 %3,237 / 5,869

54.0 %3,014 / 5,577

52.6 %3,068 / 5,835

53.7 %3,055 / 5,686

53.6 %3,066 / 5,716

50.8 %3,008 / 5,922

48.3 %2,844 / 5,894

55.3 %3,202 / 5,789

5.3 %261 / 4,913

61.1 %3,578 / 5,853

53.8 %3,468 / 6,443

54.1 %3,491 / 6,452

53.7 %3,488 / 6,497

53.0 %3,481 / 6,567

51.1 %3,145 / 6,154

52.2 %2,982 / 5,710

51.4 %3,042 / 5,915

52.4 %3,012 / 5,749

52.2 %3,027 / 5,800

49.0 %2,970 / 6,061

45.2 %2,793 / 6,182

53.6 %3,134 / 5,850

5.0 %218 / 4,327

62.5 %3,541 / 5,668

62.6 %3,542 / 5,659

61.9 %3,550 / 5,736

59.4 %3,476 / 5,850

57.0 %3,124 / 5,485

55.8 %2,980 / 5,336

54.1 %3,022 / 5,583

56.0 %3,001 / 5,357

55.6 %3,036 / 5,464

51.2 %2,933 / 5,728

49.0 %2,804 / 5,723

55.5 %3,127 / 5,639

6.5 %307 / 4,692

85.4 %4,339 / 5,078

87.3 %4,416 / 5,061

78.2 %4,178 / 5,341

51.8 %3,134 / 6,054

56.6 %3,075 / 5,430

55.7 %3,147 / 5,652

56.5 %3,128 / 5,535

55.1 %3,089 / 5,606

51.0 %2,977 / 5,839

51.1 %2,938 / 5,747

58.3 %3,258 / 5,585

6.8 %320 / 4,711

86.6 %4,398 / 5,077

84.5 %4,359 / 5,158

51.6 %3,139 / 6,084

55.2 %3,038 / 5,508

54.6 %3,121 / 5,713

55.5 %3,107 / 5,595

54.5 %3,081 / 5,650

51.1 %2,993 / 5,860

50.5 %2,917 / 5,779

57.7 %3,247 / 5,632

7.8 %371 / 4,729

77.1 %4,173 / 5,409

51.2 %3,146 / 6,142

55.3 %3,098 / 5,599

54.6 %3,168 / 5,797

56.0 %3,142 / 5,614

54.7 %3,103 / 5,671

50.3 %2,985 / 5,934

49.5 %2,951 / 5,956

58.1 %3,286 / 5,652

7.4 %348 / 4,686

50.0 %3,105 / 6,216

51.9 %2,991 / 5,767

51.5 %3,068 / 5,962

53.7 %3,076 / 5,729

52.2 %3,036 / 5,812

51.1 %3,027 / 5,918

44.8 %2,865 / 6,398

55.0 %3,192 / 5,801

3.7 %151 / 4,136

53.8 %2,755 / 5,124

51.7 %2,797 / 5,408

54.4 %2,822 / 5,187

51.6 %2,768 / 5,364

47.5 %2,702 / 5,686

46.2 %2,618 / 5,672

54.3 %2,915 / 5,371

4.0 %138 / 3,449

84.5 %3,283 / 3,886

81.1 %3,153 / 3,890

63.8 %2,813 / 4,411

58.4 %2,733 / 4,677

59.9 %2,635 / 4,396

66.0 %2,921 / 4,428

5.1 %187 / 3,663

80.1 %3,211 / 4,009

65.0 %2,884 / 4,434

60.8 %2,856 / 4,696

61.1 %2,758 / 4,512

67.7 %3,051 / 4,508

4.6 %160 / 3,501

67.0 %2,837 / 4,237

60.4 %2,778 / 4,597

59.0 %2,667 / 4,524

66.8 %2,993 / 4,481

3.6 %126 / 3,472

68.5 %2,981 / 4,350

57.9 %2,698 / 4,656

68.0 %3,011 / 4,427

4.5 %168 / 3,700

53.8 %2,692 / 5,007

61.6 %2,951 / 4,791

3.4 %115 / 3,371

61.9 %2,837 / 4,581

4.6 %171 / 3,727

Escherichia coli

strain BW2952




Escherichia coli



Escherichia coli


I


Escherichia coli

B strain REL606


Escherichia coli

strain ATCC 8739


Escherichia coli


10B


Escherichia coli



Escherichia coli


1655



I1



S





I39






Escherichia coli

strain APEC O

1


Escherichia coli

strain SMS-3-5



1a


Escherichia coli

strain E24377A




Escherichia coli

strain UM

N026


Escherichia coli

strain UTI89


Escherichia coli

strain CFT073


Escherichia coli

serotype O127:H

6 strain E2348/69


Escherichia coli

serotype O157:H

7 strain Sakai


Escherichia coli

serotype O157:H

7 strain TW14359


Escherichia coli

serotype O157:H

7 strain EDL933


Escherichia coli

serotype O157:H

7 strain EC4115



strain ATCC 35469


Shigella flexneri

2a strain 2457T


Shigella flexneri

2a strain 301


Shigella flexneri

5 strain 8401




Shigella boydii

strain CDC 3083-94






Esche

richi

a coli

stra

in B

W29

52

4,08

4 pro

tein

s, 3,

817

fam

ilies

Esche

richi

a coli

stra

in B

L21

4,08

7 pro

tein

s, 3,

833

fam

ilies

Esche

richi

a coli

stra

in B

L21(D

E3) -

Korea

Res IB

B

4,15

3 pro

tein

s, 3,

900

fam

ilies

Esche

richi

a coli

stra

in B

L21(D

E3) -

JGI

4,22

8 pro

tein

s, 3,

946

fam

ilies

Esche

richi

a coli

B stra

in R

EL606

4,20

5 pro

tein

s, 3,

936

fam

ilies

Esche

richi

a coli

stra

in A

TCC 873

9

4,20

0 pro

tein

s, 3,

977

fam

ilies

Esche

richi

a coli

stra

in K

-12,

subst

rain

DH

10B

4,12

6 pro

tein

s, 3,

797

fam

ilies

Esche

richi

a coli

stra

in K

-12,

subst

rain

W31

10

4,22

6 pro

tein

s, 3,

965

fam

ilies

Esche

richi

a coli

stra

in K

-12,

subst

rain

MG

1655

4,15

0 pro

tein

s, 3,

912

fam

ilies

Esche

richi

a coli

stra

in IA

I1

4,35

3 pro

tein

s, 4,

142

fam

ilies

Esche

richi

a coli

stra

in H

S

4,37

8 pro

tein

s, 4,

121

fam

ilies

Esche

richi

a coli

stra

in 5

36

4,62

0 pro

tein

s, 4,

327

fam

ilies

Esche

richi

a coli

stra

in IA

I39

4,73

2 pro

tein

s, 4,

244

fam

ilies

Esche

richi

a coli

stra

in 5

5989

4,76

3 pro

tein

s, 4,

376

fam

ilies

Esche

richi

a coli

stra

in S

88

4,83

2 pro

tein

s, 4,

485

fam

ilies

Esche

richi

a coli

stra

in A

PEC O1

4,85

1 pro

tein

s, 4,

526

fam

ilies

Esche

richi

a coli

stra

in S

MS-

3-5

4,91

3 pro

tein

s, 4,

551

fam

ilies

Esche

richi

a coli

stra

in E

D1a

4,91

5 pro

tein

s, 4,

451

fam

ilies

Esche

richi

a coli

stra

in E

2437

7A

4,99

1 pro

tein

s, 4,

605

fam

ilies

Esche

richi

a coli

stra

in S

E11

5,00

2 pro

tein

s, 4,

663

fam

ilies

Esche

richi

a coli

stra

in U

MN

026

5,01

7 pro

tein

s, 4,

676

fam

ilies

Esche

richi

a coli

stra

in U

TI89

5,16

6 pro

tein

s, 4,

866

fam

ilies

Esche

richi

a coli

stra

in C

FT073

5,33

9 pro

tein

s, 4,

913

fam

ilies

Esche

richi

a coli

sero

type O

127:

H6

stra

in E

2348

/69

4,65

3 pro

tein

s, 4,

327

fam

ilies

Esche

richi

a coli

sero

type O

157:

H7

stra

in S

akai

5,31

8 pro

tein

s, 4,

692

fam

ilies

Esche

richi

a coli

sero

type O

157:

H7

stra

in T

W14

359

5,37

2 pro

tein

s, 4,

711

fam

ilies

Esche

richi

a coli

sero

type O

157:

H7

stra

in E

DL93

3

5,41

1 pro

tein

s, 4,

729

fam

ilies

Esche

richi

a coli

sero

type O

157:

H7

stra

in E

C4115

5,47

7 pro

tein

s, 4,

686

fam

ilies

Esche

richi

a fer

guso

nii

stra

in A

TCC 354

69

4,32

1 pro

tein

s, 4,

136

fam

ilies

Shige

lla fl

exner

i

2a st

rain

245

7T

4,06

1 pro

tein

s, 3,

449

fam

ilies

Shige

lla fl

exner

i

2a st

rain

301

4,44

0 pro

tein

s, 3,

663

fam

ilies

Shige

lla fl

exner

i

5 st

rain

840

1

4,11

5 pro

tein

s, 3,

501

fam

ilies

Shige

lla bo

ydii

stra

in S

b227

4,28

2 pro

tein

s, 3,

472

fam

ilies

Shige

lla bo

ydii

stra

in C

DC 3

083-

94

4,55

7 pro

tein

s, 3,

700

fam

ilies

Shige

lla d

ysen

teriae

stra

in S

d197

4,50

2 pro

tein

s, 3,

371

fam

ilies

Shige

lla so

nnei

stra

in S

s046

4,47

1 pro

tein

s, 3,

727

fam

ilies


20.0 %0.0 %


100.0 %40.0 %

K-12

B

HS

O157:H7

Shigella

APEC01

28 E. coli genomes[all so far, as of 27 Aug 2009!]

3.4 %115 / 3,374

58.0 %2,701 / 4,658

61.8 %2,839 / 4,591

49.7 %2,766 / 5,563

50.9 %2,836 / 5,575

45.7 %2,612 / 5,711

43.6 %2,693 / 6,173

40.9 %2,701 / 6,596

44.2 %2,690 / 6,088

45.5 %2,668 / 5,870

53.7 %2,692 / 5,010

51.5 %2,845 / 5,526

46.3 %2,700 / 5,832

49.5 %2,575 / 5,203

47.1 %2,796 / 5,931

47.9 %2,844 / 5,942

53.8 %2,818 / 5,236

58.9 %2,667 / 4,528

45.5 %2,650 / 5,823

50.7 %2,865 / 5,655

51.8 %2,803 / 5,416

49.3 %2,869 / 5,821

53.0 %2,740 / 5,169

53.9 %2,801 / 5,197

50.5 %2,947 / 5,837

49.2 %2,952 / 5,995

42.7 %2,581 / 6,049

43.9 %2,748 / 6,260

44.8 %2,794 / 6,243

44.8 %2,865 / 6,401

43.1 %2,682 / 6,216

42.7 %2,642 / 6,190

45.0 %2,810 / 6,240

42.7 %2,740 / 6,411

43.4 %2,792 / 6,438

41.9 %2,638 / 6,301

42.0 %2,629 / 6,257

44.6 %2,787 / 6,252

47.1 %2,930 / 6,218

61.1 %2,759 / 4,518

44.9 %2,794 / 6,224

49.0 %2,804 / 5,726

48.7 %2,825 / 5,799

51.4 %2,812 / 5,471

50.1 %2,789 / 5,565

50.4 %2,803 / 5,558

52.0 %2,838 / 5,456

50.0 %2,886 / 5,771

59.8 %2,636 / 4,405

52.8 %2,752 / 5,215

48.8 %2,776 / 5,685

48.8 %2,791 / 5,714

47.5 %2,762 / 5,813

47.7 %2,778 / 5,828

48.0 %2,791 / 5,816

50.4 %2,861 / 5,681

47.1 %2,768 / 5,876

49.8 %2,800 / 5,622

50.9 %2,831 / 5,559

3.6 %126 / 3,474

68.1 %3,014 / 4,429

58.3 %3,014 / 5,171

55.2 %3,044 / 5,517

54.0 %2,880 / 5,335

51.1 %2,879 / 5,631

49.7 %2,975 / 5,991

55.2 %2,960 / 5,363

51.6 %2,905 / 5,632

68.5 %2,981 / 4,352

57.7 %3,104 / 5,379

56.6 %2,955 / 5,225

55.7 %2,736 / 4,913

54.5 %2,969 / 5,444

53.2 %3,066 / 5,763

62.1 %3,047 / 4,910

66.9 %2,838 / 4,239

51.2 %2,868 / 5,603

58.1 %3,140 / 5,409

62.5 %3,070 / 4,912

57.1 %3,080 / 5,391

60.5 %2,934 / 4,848

62.2 %3,024 / 4,865

54.3 %3,101 / 5,710

54.3 %3,103 / 5,710

49.7 %2,734 / 5,497

51.4 %2,922 / 5,682

52.3 %2,964 / 5,664

52.2 %3,036 / 5,814

50.8 %2,861 / 5,634

50.1 %2,816 / 5,617

52.6 %2,980 / 5,661

49.0 %2,890 / 5,902

50.4 %2,963 / 5,878

48.7 %2,796 / 5,742

49.2 %2,799 / 5,688

52.9 %2,984 / 5,644

50.4 %3,073 / 6,099

65.0 %2,884 / 4,440

51.8 %3,027 / 5,842

55.5 %3,036 / 5,466

58.1 %3,069 / 5,286

57.4 %3,035 / 5,290

55.4 %3,019 / 5,450

58.9 %3,019 / 5,124

58.0 %3,092 / 5,334

56.5 %3,073 / 5,440

63.6 %2,813 / 4,420

63.0 %2,998 / 4,757

56.1 %3,012 / 5,369

59.0 %3,037 / 5,144

55.3 %2,910 / 5,262

55.8 %2,939 / 5,264

57.6 %3,079 / 5,342

58.6 %3,072 / 5,246

55.1 %2,992 / 5,429

56.4 %3,054 / 5,416

54.7 %3,020 / 5,520

4.6 %172 / 3,730

61.3 %3,171 / 5,172

60.7 %3,276 / 5,401

56.0 %3,053 / 5,452

53.2 %3,040 / 5,711

53.0 %3,163 / 5,963

57.4 %3,122 / 5,439

55.1 %3,091 / 5,614

61.5 %2,951 / 4,795

62.1 %3,267 / 5,264

59.2 %3,119 / 5,270

58.4 %2,880 / 4,929

56.0 %3,126 / 5,585

54.9 %3,204 / 5,836

66.4 %3,223 / 4,852

66.8 %2,994 / 4,485

52.7 %3,009 / 5,714

61.1 %3,332 / 5,455

66.3 %3,228 / 4,866

59.2 %3,232 / 5,456

65.0 %3,115 / 4,790

66.8 %3,205 / 4,795

57.6 %3,277 / 5,690

57.7 %3,286 / 5,691

52.0 %2,874 / 5,529

54.1 %3,073 / 5,678

54.8 %3,113 / 5,677

55.0 %3,192 / 5,805

53.3 %3,003 / 5,629

52.5 %2,959 / 5,635

55.3 %3,130 / 5,662

51.7 %3,057 / 5,908

52.9 %3,117 / 5,891

51.2 %2,942 / 5,750

51.7 %2,943 / 5,691

54.8 %3,121 / 5,700

53.8 %3,258 / 6,053

67.6 %3,052 / 4,514

53.2 %3,136 / 5,892

55.4 %3,127 / 5,643

63.1 %3,285 / 5,203

58.5 %3,168 / 5,412

57.1 %3,139 / 5,496

61.9 %3,159 / 5,101

62.3 %3,283 / 5,266

62.7 %3,307 / 5,272

66.0 %2,925 / 4,435

66.7 %3,132 / 4,695

55.6 %3,103 / 5,580

62.1 %3,204 / 5,158

58.3 %3,073 / 5,272

58.3 %3,085 / 5,289

61.3 %3,228 / 5,266

60.2 %3,206 / 5,330

60.1 %3,190 / 5,312

58.8 %3,230 / 5,496

56.2 %3,149 / 5,603

3.3 %137 / 4,125

70.8 %3,686 / 5,208

63.7 %3,360 / 5,277

60.3 %3,283 / 5,443

62.1 %3,485 / 5,611

62.9 %3,420 / 5,435

60.2 %3,366 / 5,596

54.3 %2,929 / 5,394

63.7 %3,533 / 5,545

65.6 %3,395 / 5,173

53.2 %2,943 / 5,537

63.9 %3,379 / 5,288

61.1 %3,488 / 5,708

75.6 %3,531 / 4,670

61.1 %3,045 / 4,983

57.3 %3,234 / 5,644

69.9 %3,671 / 5,255

77.5 %3,572 / 4,612

65.7 %3,528 / 5,366

72.7 %3,385 / 4,659

75.8 %3,503 / 4,621

57.7 %3,421 / 5,929

58.6 %3,460 / 5,907

53.7 %3,063 / 5,702

56.3 %3,297 / 5,853

57.1 %3,337 / 5,842

57.1 %3,418 / 5,981

55.7 %3,231 / 5,798

54.8 %3,177 / 5,795

57.6 %3,357 / 5,832

55.6 %3,278 / 5,891

55.4 %3,338 / 6,029

53.2 %3,157 / 5,930

54.6 %3,176 / 5,820

57.2 %3,336 / 5,828

56.4 %3,496 / 6,197

58.2 %3,031 / 5,209

58.3 %3,444 / 5,906

62.4 %3,336 / 5,350

74.5 %3,579 / 4,805

66.4 %3,462 / 5,212

60.8 %3,347 / 5,505

64.3 %3,399 / 5,287

70.3 %3,582 / 5,092

63.7 %3,476 / 5,461

61.0 %2,989 / 4,902

75.3 %3,460 / 4,597

61.8 %3,300 / 5,337

69.6 %3,517 / 5,054

59.2 %3,241 / 5,477

59.1 %3,256 / 5,513

68.2 %3,498 / 5,131

67.8 %3,528 / 5,202

69.6 %3,501 / 5,029

68.7 %3,555 / 5,173

62.1 %3,453 / 5,563

5.0 %232 / 4,611

65.7 %3,604 / 5,483

59.4 %3,413 / 5,747

63.1 %3,686 / 5,846

63.4 %3,601 / 5,676

62.9 %3,604 / 5,732

53.0 %3,020 / 5,703

62.4 %3,636 / 5,830

65.3 %3,568 / 5,468

52.9 %3,070 / 5,807

61.2 %3,469 / 5,670

59.1 %3,588 / 6,072

68.8 %3,566 / 5,180

58.0 %3,110 / 5,362

55.0 %3,330 / 6,056

71.0 %3,903 / 5,495

68.5 %3,564 / 5,203

64.3 %3,655 / 5,684

66.4 %3,428 / 5,163

68.8 %3,536 / 5,142

57.6 %3,574 / 6,205

58.5 %3,607 / 6,164

54.6 %3,244 / 5,945

57.4 %3,483 / 6,066

58.1 %3,522 / 6,060

58.3 %3,600 / 6,180

56.5 %3,414 / 6,041

55.7 %3,358 / 6,034

58.4 %3,544 / 6,069

56.7 %3,467 / 6,113

56.9 %3,541 / 6,221

54.1 %3,337 / 6,173

55.0 %3,348 / 6,086

57.7 %3,518 / 6,096

57.2 %3,682 / 6,435

56.7 %3,107 / 5,484

56.5 %3,541 / 6,264

59.4 %3,425 / 5,769

71.2 %3,721 / 5,229

61.7 %3,511 / 5,690

58.1 %3,431 / 5,902

61.0 %3,471 / 5,690

69.5 %3,744 / 5,388

63.1 %3,632 / 5,759

57.7 %3,039 / 5,269

68.0 %3,501 / 5,146

59.3 %3,400 / 5,733

65.7 %3,588 / 5,465

58.7 %3,391 / 5,772

58.8 %3,412 / 5,805

65.7 %3,622 / 5,509

65.2 %3,629 / 5,570

65.3 %3,575 / 5,475

65.0 %3,631 / 5,588

59.3 %3,543 / 5,977

5.2 %226 / 4,340

60.1 %3,329 / 5,541

69.5 %3,766 / 5,416

67.6 %3,599 / 5,324

65.7 %3,564 / 5,427

50.9 %2,844 / 5,588

61.4 %3,509 / 5,713

68.2 %3,538 / 5,185

53.4 %3,003 / 5,625

57.5 %3,223 / 5,606

58.2 %3,441 / 5,908

65.6 %3,339 / 5,090

55.3 %2,913 / 5,267

54.1 %3,177 / 5,873

68.5 %3,691 / 5,386

65.4 %3,337 / 5,101

62.7 %3,488 / 5,563

63.6 %3,216 / 5,060

65.9 %3,321 / 5,036

55.4 %3,362 / 6,067

56.2 %3,391 / 6,039

54.7 %3,115 / 5,694

58.6 %3,381 / 5,769

58.9 %3,406 / 5,785

58.2 %3,455 / 5,939

59.4 %3,366 / 5,671

58.6 %3,322 / 5,673

59.1 %3,416 / 5,778

58.2 %3,384 / 5,811

58.1 %3,437 / 5,913

56.7 %3,301 / 5,824

58.5 %3,324 / 5,682

60.0 %3,446 / 5,748

56.3 %3,518 / 6,247

52.3 %2,894 / 5,536

52.8 %3,279 / 6,212

58.3 %3,260 / 5,590

67.9 %3,477 / 5,120

60.1 %3,320 / 5,528

55.5 %3,223 / 5,811

59.9 %3,302 / 5,517

66.0 %3,525 / 5,339

61.3 %3,457 / 5,640

53.5 %2,837 / 5,304

64.8 %3,268 / 5,044

58.2 %3,237 / 5,564

63.8 %3,394 / 5,321

57.0 %3,201 / 5,614

56.7 %3,208 / 5,653

64.2 %3,437 / 5,356

62.7 %3,436 / 5,476

63.0 %3,376 / 5,359

61.4 %3,391 / 5,525

56.0 %3,307 / 5,902

5.3 %232 / 4,393

58.8 %3,430 / 5,838

59.9 %3,392 / 5,661

58.0 %3,351 / 5,776

48.5 %2,857 / 5,890

58.6 %3,447 / 5,883

63.0 %3,426 / 5,438

51.2 %2,943 / 5,744

77.2 %3,823 / 4,952

71.9 %3,919 / 5,447

62.7 %3,282 / 5,237

52.7 %2,908 / 5,513

62.4 %3,499 / 5,606

59.2 %3,425 / 5,787

63.1 %3,290 / 5,214

65.2 %3,597 / 5,519

60.7 %3,158 / 5,205

63.4 %3,274 / 5,163

53.7 %3,329 / 6,202

54.3 %3,354 / 6,174

51.9 %3,048 / 5,868

55.2 %3,298 / 5,980

55.9 %3,340 / 5,973

55.4 %3,397 / 6,132

55.5 %3,264 / 5,884

54.5 %3,214 / 5,895

56.3 %3,353 / 5,957

55.1 %3,298 / 5,989

54.8 %3,356 / 6,120

53.3 %3,208 / 6,022

54.7 %3,219 / 5,885

56.2 %3,349 / 5,961

54.1 %3,467 / 6,414

50.9 %2,922 / 5,736

66.9 %3,786 / 5,656

64.2 %3,477 / 5,412

63.5 %3,365 / 5,296

69.5 %3,636 / 5,232

62.6 %3,508 / 5,603

63.9 %3,419 / 5,354

61.1 %3,392 / 5,552

62.1 %3,499 / 5,633

52.1 %2,866 / 5,505

63.4 %3,248 / 5,127

64.7 %3,466 / 5,361

61.9 %3,360 / 5,426

55.5 %3,178 / 5,730

55.5 %3,195 / 5,759

60.2 %3,327 / 5,526

65.5 %3,549 / 5,416

61.9 %3,347 / 5,406

58.2 %3,305 / 5,682

69.3 %3,767 / 5,435

5.3 %246 / 4,684

69.0 %3,777 / 5,471

70.4 %3,843 / 5,459

48.8 %2,978 / 6,105

60.7 %3,651 / 6,018

65.3 %3,625 / 5,548

52.4 %3,100 / 5,912

57.4 %3,359 / 5,850

57.6 %3,559 / 6,181

64.0 %3,461 / 5,407

52.5 %3,025 / 5,761

54.0 %3,309 / 6,129

68.3 %3,848 / 5,632

63.9 %3,449 / 5,401

61.1 %3,608 / 5,906

62.1 %3,334 / 5,369

64.1 %3,436 / 5,357

58.5 %3,575 / 6,107

59.2 %3,606 / 6,091

57.6 %3,321 / 5,767

61.6 %3,591 / 5,831

61.8 %3,613 / 5,845

61.8 %3,675 / 5,951

61.8 %3,562 / 5,762

61.0 %3,520 / 5,766

61.8 %3,614 / 5,852

60.9 %3,588 / 5,894

60.7 %3,646 / 6,010

59.7 %3,510 / 5,882

60.7 %3,512 / 5,784

62.9 %3,663 / 5,822

60.1 %3,755 / 6,246

49.7 %3,003 / 6,042

53.2 %3,427 / 6,438

60.3 %3,450 / 5,726

67.0 %3,605 / 5,380

60.0 %3,452 / 5,749

56.0 %3,361 / 5,997

58.8 %3,428 / 5,826

65.2 %3,647 / 5,592

60.5 %3,572 / 5,904

50.8 %2,937 / 5,787

62.7 %3,372 / 5,382

59.6 %3,411 / 5,720

63.3 %3,523 / 5,564

59.4 %3,396 / 5,717

58.5 %3,387 / 5,790

65.6 %3,637 / 5,547

61.9 %3,574 / 5,777

61.3 %3,467 / 5,653

60.3 %3,502 / 5,803

55.7 %3,441 / 6,183

6.9 %303 / 4,419

67.4 %3,656 / 5,423

53.9 %2,969 / 5,507

61.4 %3,553 / 5,787

66.1 %3,544 / 5,363

55.7 %3,127 / 5,611

57.8 %3,297 / 5,703

57.5 %3,472 / 6,039

63.1 %3,362 / 5,328

56.0 %2,985 / 5,328

54.0 %3,227 / 5,977

66.0 %3,676 / 5,567

64.7 %3,397 / 5,249

63.1 %3,563 / 5,644

61.4 %3,243 / 5,283

63.2 %3,340 / 5,282

61.3 %3,555 / 5,798

62.5 %3,583 / 5,736

60.6 %3,315 / 5,474

65.4 %3,602 / 5,508

65.5 %3,621 / 5,528

65.3 %3,685 / 5,639

65.6 %3,570 / 5,443

64.9 %3,528 / 5,438

65.7 %3,624 / 5,517

63.4 %3,557 / 5,610

62.9 %3,615 / 5,750

63.4 %3,518 / 5,547

63.9 %3,505 / 5,487

65.4 %3,626 / 5,542

63.4 %3,753 / 5,924

53.3 %2,974 / 5,580

54.2 %3,376 / 6,224

60.6 %3,369 / 5,560

66.0 %3,496 / 5,295

60.1 %3,376 / 5,615

58.4 %3,331 / 5,707

59.2 %3,342 / 5,649

66.6 %3,599 / 5,402

60.6 %3,489 / 5,759

54.6 %2,918 / 5,344

62.4 %3,291 / 5,271

60.2 %3,341 / 5,546

62.6 %3,424 / 5,468

62.0 %3,374 / 5,440

61.5 %3,380 / 5,497

67.3 %3,606 / 5,356

63.3 %3,515 / 5,556

61.4 %3,406 / 5,547

60.2 %3,415 / 5,672

56.8 %3,396 / 5,976

6.8 %305 / 4,482

50.8 %2,909 / 5,729

60.1 %3,541 / 5,896

64.7 %3,525 / 5,448

52.7 %3,047 / 5,787

55.5 %3,250 / 5,858

55.9 %3,428 / 6,130

62.1 %3,361 / 5,408

53.5 %2,946 / 5,502

51.6 %3,164 / 6,136

65.0 %3,679 / 5,656

62.5 %3,363 / 5,380

59.0 %3,474 / 5,887

60.0 %3,228 / 5,378

62.4 %3,341 / 5,356

57.4 %3,493 / 6,089

57.8 %3,514 / 6,084

55.9 %3,231 / 5,779

60.0 %3,497 / 5,824

60.4 %3,528 / 5,837

60.3 %3,592 / 5,958

60.2 %3,469 / 5,762

59.5 %3,427 / 5,761

60.0 %3,524 / 5,872

58.6 %3,475 / 5,928

57.9 %3,513 / 6,072

58.3 %3,425 / 5,870

59.1 %3,413 / 5,777

60.8 %3,549 / 5,838

58.6 %3,664 / 6,252

51.8 %2,954 / 5,701

52.1 %3,332 / 6,394

59.5 %3,370 / 5,665

65.1 %3,506 / 5,383

58.2 %3,337 / 5,735

54.2 %3,255 / 6,011

57.3 %3,328 / 5,807

64.3 %3,545 / 5,514

58.0 %3,427 / 5,905

52.2 %2,881 / 5,516

60.8 %3,266 / 5,376

59.1 %3,334 / 5,643

62.8 %3,444 / 5,481

58.2 %3,315 / 5,699

57.3 %3,300 / 5,762

63.2 %3,503 / 5,541

59.6 %3,443 / 5,776

58.8 %3,345 / 5,693

58.5 %3,396 / 5,804

54.3 %3,334 / 6,141

4.5 %168 / 3,700

56.0 %3,109 / 5,555

53.7 %2,939 / 5,474

54.5 %2,777 / 5,100

50.6 %2,899 / 5,724

50.4 %3,009 / 5,966

55.9 %2,923 / 5,231

60.4 %2,778 / 4,598

47.8 %2,785 / 5,823

54.1 %3,070 / 5,678

55.9 %2,946 / 5,267

53.8 %3,025 / 5,623

54.6 %2,827 / 5,176

55.9 %2,910 / 5,205

49.7 %2,968 / 5,971

50.0 %2,984 / 5,973

48.1 %2,717 / 5,651

50.0 %2,904 / 5,812

50.8 %2,946 / 5,800

51.1 %3,027 / 5,918

49.1 %2,833 / 5,775

48.2 %2,787 / 5,777

51.0 %2,954 / 5,793

47.3 %2,878 / 6,081

48.9 %2,951 / 6,039

47.3 %2,781 / 5,878

47.7 %2,784 / 5,831

51.1 %2,968 / 5,806

49.3 %3,066 / 6,218

60.7 %2,855 / 4,700

48.7 %2,972 / 6,098

51.2 %2,933 / 5,728

53.4 %2,983 / 5,589

53.5 %2,950 / 5,509

52.3 %2,936 / 5,609

52.9 %2,911 / 5,500

54.7 %3,001 / 5,491

52.9 %2,992 / 5,656

58.3 %2,733 / 4,684

56.3 %2,877 / 5,112

51.2 %2,911 / 5,691

54.3 %2,950 / 5,429

51.1 %2,826 / 5,527

51.3 %2,848 / 5,553

53.0 %2,967 / 5,596

54.9 %3,014 / 5,486

50.8 %2,917 / 5,747

52.4 %2,989 / 5,701

51.5 %2,972 / 5,770

6.6 %302 / 4,610

64.7 %3,584 / 5,536

57.4 %3,175 / 5,530

57.1 %3,391 / 5,934

56.4 %3,528 / 6,258

64.9 %3,504 / 5,401

58.1 %3,101 / 5,336

53.5 %3,293 / 6,154

64.0 %3,716 / 5,810

67.3 %3,587 / 5,330

63.5 %3,679 / 5,791

63.1 %3,381 / 5,355

65.1 %3,483 / 5,347

54.4 %3,480 / 6,393

54.5 %3,486 / 6,394

51.9 %3,176 / 6,118

55.2 %3,428 / 6,210

55.8 %3,466 / 6,207

56.0 %3,545 / 6,328

54.3 %3,351 / 6,170

53.6 %3,307 / 6,172

56.3 %3,485 / 6,195

53.8 %3,390 / 6,304

54.1 %3,460 / 6,390

52.2 %3,288 / 6,297

52.9 %3,291 / 6,219

55.9 %3,471 / 6,207

54.9 %3,621 / 6,590

58.5 %3,149 / 5,379

53.2 %3,445 / 6,481

57.0 %3,387 / 5,945

63.7 %3,557 / 5,582

58.7 %3,450 / 5,875

56.0 %3,396 / 6,062

59.6 %3,443 / 5,774

61.7 %3,564 / 5,778

60.0 %3,565 / 5,941

58.0 %3,053 / 5,267

64.4 %3,437 / 5,333

57.1 %3,364 / 5,890

64.0 %3,567 / 5,571

55.1 %3,288 / 5,968

55.0 %3,297 / 5,999

61.5 %3,528 / 5,739

63.5 %3,633 / 5,719

62.3 %3,534 / 5,672

61.3 %3,567 / 5,820

55.5 %3,451 / 6,219

5.2 %224 / 4,299

55.6 %3,053 / 5,491

60.7 %3,332 / 5,487

60.8 %3,522 / 5,793

70.0 %3,451 / 4,932

57.5 %2,967 / 5,161

57.2 %3,282 / 5,738

66.1 %3,610 / 5,462

69.7 %3,440 / 4,935

65.7 %3,580 / 5,450

67.7 %3,321 / 4,904

70.2 %3,425 / 4,882

57.2 %3,413 / 5,962

57.8 %3,438 / 5,943

54.8 %3,111 / 5,682

59.2 %3,395 / 5,733

59.6 %3,422 / 5,742

59.3 %3,487 / 5,880

60.0 %3,380 / 5,634

59.3 %3,336 / 5,628

59.5 %3,426 / 5,760

57.6 %3,365 / 5,843

57.5 %3,421 / 5,953

57.8 %3,326 / 5,752

58.7 %3,321 / 5,659

60.9 %3,469 / 5,700

58.0 %3,566 / 6,149

54.7 %2,959 / 5,414

56.8 %3,435 / 6,044

61.1 %3,345 / 5,478

67.0 %3,446 / 5,141

63.5 %3,423 / 5,390

59.2 %3,348 / 5,659

62.0 %3,354 / 5,407

65.4 %3,492 / 5,339

63.4 %3,514 / 5,542

55.7 %2,896 / 5,199

71.8 %3,444 / 4,796

61.0 %3,320 / 5,447

67.5 %3,491 / 5,170

58.6 %3,243 / 5,535

58.1 %3,243 / 5,584

64.3 %3,441 / 5,348

65.6 %3,523 / 5,371

65.4 %3,436 / 5,256

63.2 %3,449 / 5,458

59.2 %3,422 / 5,777

4.1 %159 / 3,895

51.0 %2,905 / 5,697

49.1 %3,015 / 6,146

57.2 %2,983 / 5,216

55.6 %2,767 / 4,979

46.4 %2,802 / 6,033

53.3 %3,114 / 5,840

57.0 %2,999 / 5,261

55.5 %3,114 / 5,615

56.4 %2,900 / 5,146

57.8 %2,976 / 5,146

49.2 %3,029 / 6,154

49.7 %3,043 / 6,119

46.8 %2,766 / 5,910

49.9 %3,011 / 6,037

50.0 %3,024 / 6,054

49.9 %3,090 / 6,195

50.3 %2,988 / 5,946

49.6 %2,941 / 5,924

49.9 %3,024 / 6,055

48.5 %2,962 / 6,110

48.5 %3,024 / 6,237

48.8 %2,939 / 6,027

49.5 %2,948 / 5,951

50.7 %3,047 / 6,011

49.2 %3,140 / 6,376

57.9 %2,844 / 4,909

47.8 %2,960 / 6,193

50.6 %2,929 / 5,785

54.9 %3,009 / 5,476

51.1 %2,932 / 5,734

49.4 %2,931 / 5,930

52.2 %2,942 / 5,631

54.7 %3,084 / 5,635

52.2 %3,039 / 5,824

54.9 %2,728 / 4,972

56.6 %2,914 / 5,146

52.0 %2,922 / 5,621

54.3 %3,005 / 5,531

51.0 %2,884 / 5,653

51.2 %2,901 / 5,667

54.9 %3,013 / 5,486

55.8 %3,076 / 5,516

53.6 %2,977 / 5,551

54.4 %3,046 / 5,604

50.7 %2,979 / 5,873

4.4 %192 / 4,335

73.5 %3,943 / 5,363

67.2 %3,401 / 5,059

56.1 %3,002 / 5,355

65.9 %3,594 / 5,452

62.4 %3,520 / 5,645

67.4 %3,404 / 5,052

65.3 %3,568 / 5,466

65.4 %3,277 / 5,013

67.9 %3,389 / 4,991

56.3 %3,413 / 6,059

57.1 %3,440 / 6,028

51.6 %3,026 / 5,863

54.2 %3,250 / 5,994

54.9 %3,290 / 5,990

55.0 %3,372 / 6,130

53.7 %3,183 / 5,924

52.7 %3,133 / 5,942

55.5 %3,312 / 5,971

53.6 %3,230 / 6,028

53.4 %3,296 / 6,176

51.7 %3,130 / 6,058

52.7 %3,130 / 5,939

54.7 %3,286 / 6,002

54.0 %3,449 / 6,387

54.2 %3,009 / 5,551

70.6 %3,875 / 5,491

67.0 %3,527 / 5,268

67.1 %3,461 / 5,160

74.8 %3,771 / 5,039

67.2 %3,634 / 5,404

68.0 %3,518 / 5,175

65.6 %3,519 / 5,363

64.0 %3,533 / 5,523

55.8 %2,964 / 5,315

68.5 %3,375 / 4,930

67.7 %3,521 / 5,200

64.8 %3,438 / 5,302

58.2 %3,254 / 5,593

58.1 %3,272 / 5,631

62.9 %3,397 / 5,404

67.2 %3,567 / 5,309

64.8 %3,418 / 5,276

60.7 %3,370 / 5,552

74.3 %3,886 / 5,228

4.8 %236 / 4,894

62.2 %3,456 / 5,558

53.3 %3,056 / 5,731

70.5 %3,940 / 5,592

60.9 %3,665 / 6,020

62.0 %3,444 / 5,557

63.4 %3,730 / 5,880

59.9 %3,319 / 5,540

62.7 %3,442 / 5,491

56.0 %3,569 / 6,377

56.4 %3,591 / 6,362

50.8 %3,159 / 6,220

54.2 %3,416 / 6,300

54.7 %3,448 / 6,304

55.1 %3,534 / 6,412

53.2 %3,336 / 6,265

52.3 %3,284 / 6,281

54.8 %3,451 / 6,302

52.9 %3,373 / 6,380

53.0 %3,445 / 6,502

51.2 %3,279 / 6,401

52.4 %3,289 / 6,280

55.4 %3,484 / 6,289

53.9 %3,612 / 6,698

52.2 %3,070 / 5,882

73.2 %4,184 / 5,719

65.2 %3,686 / 5,652

61.9 %3,502 / 5,654

76.4 %4,034 / 5,278

64.7 %3,742 / 5,786

63.9 %3,613 / 5,653

62.7 %3,619 / 5,771

63.8 %3,747 / 5,872

53.6 %3,017 / 5,626

61.8 %3,392 / 5,485

64.3 %3,635 / 5,654

61.8 %3,531 / 5,717

55.6 %3,347 / 6,016

55.2 %3,353 / 6,069

60.1 %3,509 / 5,834

63.4 %3,674 / 5,796

61.4 %3,520 / 5,737

57.3 %3,457 / 6,034

73.2 %4,101 / 5,603

4.3 %170 / 3,965

66.0 %3,098 / 4,692

60.2 %3,262 / 5,419

72.6 %3,680 / 5,068

83.3 %3,629 / 4,359

68.7 %3,526 / 5,136

93.1 %3,742 / 4,020

95.9 %3,848 / 4,011

63.0 %3,544 / 5,628

63.3 %3,559 / 5,622

55.9 %3,079 / 5,512

58.6 %3,314 / 5,660

59.4 %3,355 / 5,648

59.6 %3,440 / 5,774

58.0 %3,250 / 5,604

57.1 %3,196 / 5,593

59.9 %3,378 / 5,636

57.7 %3,288 / 5,695

57.5 %3,358 / 5,841

56.1 %3,199 / 5,706

56.6 %3,188 / 5,635

59.5 %3,359 / 5,644

58.8 %3,531 / 6,005

62.9 %3,086 / 4,905

59.2 %3,409 / 5,755

66.1 %3,376 / 5,111

78.2 %3,604 / 4,606

69.1 %3,474 / 5,030

63.8 %3,375 / 5,293

68.9 %3,455 / 5,017

74.0 %3,618 / 4,889

70.0 %3,588 / 5,128

66.3 %3,048 / 4,598

82.5 %3,562 / 4,316

65.3 %3,333 / 5,105

76.7 %3,631 / 4,733

63.9 %3,330 / 5,208

63.8 %3,344 / 5,241

71.6 %3,512 / 4,905

70.8 %3,524 / 4,979

77.1 %3,623 / 4,702

71.3 %3,541 / 4,966

64.4 %3,459 / 5,373

4.6 %160 / 3,502

52.8 %2,902 / 5,498

59.8 %3,180 / 5,316

65.1 %3,088 / 4,741

59.0 %3,122 / 5,292

64.4 %2,991 / 4,646

66.3 %3,079 / 4,646

55.5 %3,132 / 5,647

55.6 %3,143 / 5,652

51.3 %2,775 / 5,411

52.8 %2,958 / 5,597

53.7 %2,999 / 5,589

53.7 %3,076 / 5,730

52.3 %2,896 / 5,535

51.3 %2,846 / 5,544

54.1 %3,016 / 5,575

51.0 %2,931 / 5,746

51.8 %2,999 / 5,793

50.2 %2,839 / 5,651

50.9 %2,843 / 5,585

53.8 %3,008 / 5,590

52.8 %3,151 / 5,969

80.1 %3,212 / 4,012

52.0 %3,013 / 5,789

56.0 %3,001 / 5,358

62.2 %3,126 / 5,022

58.0 %3,044 / 5,244

55.3 %2,991 / 5,408

61.5 %3,060 / 4,974

61.1 %3,143 / 5,141

60.0 %3,144 / 5,238

81.0 %3,155 / 3,897

66.3 %3,033 / 4,576

56.6 %2,999 / 5,300

62.0 %3,097 / 4,993

58.0 %2,987 / 5,153

57.9 %2,994 / 5,174

60.7 %3,095 / 5,103

60.8 %3,122 / 5,138

59.8 %3,068 / 5,129

59.6 %3,129 / 5,250

55.0 %3,021 / 5,496

5.3 %240 / 4,559

56.7 %3,396 / 5,993

60.0 %3,261 / 5,439

61.1 %3,511 / 5,746

57.7 %3,126 / 5,414

60.4 %3,245 / 5,369

53.5 %3,353 / 6,271

53.6 %3,358 / 6,270

49.0 %2,973 / 6,072

51.1 %3,178 / 6,217

51.5 %3,205 / 6,219

52.0 %3,291 / 6,333

50.3 %3,111 / 6,180

49.6 %3,064 / 6,177

52.0 %3,225 / 6,203

50.1 %3,149 / 6,290

50.0 %3,213 / 6,432

48.2 %3,046 / 6,320

49.5 %3,065 / 6,190

51.8 %3,229 / 6,231

50.4 %3,346 / 6,637

51.0 %2,892 / 5,674

62.5 %3,703 / 5,923

62.0 %3,468 / 5,591

58.6 %3,274 / 5,583

74.6 %3,841 / 5,146

62.4 %3,537 / 5,668

62.2 %3,428 / 5,510

59.1 %3,386 / 5,726

59.8 %3,483 / 5,820

52.4 %2,844 / 5,427

62.0 %3,268 / 5,273

63.6 %3,498 / 5,497

61.4 %3,402 / 5,537

54.9 %3,195 / 5,815

54.5 %3,199 / 5,871

60.2 %3,390 / 5,631

60.6 %3,442 / 5,677

60.4 %3,368 / 5,579

54.9 %3,254 / 5,925

62.7 %3,630 / 5,794

5.2 %241 / 4,663

72.2 %3,662 / 5,073

64.6 %3,694 / 5,717

70.0 %3,535 / 5,050

72.3 %3,642 / 5,038

61.9 %3,714 / 6,001

62.2 %3,731 / 5,997

55.8 %3,276 / 5,870

59.3 %3,531 / 5,954

59.9 %3,568 / 5,956

60.4 %3,657 / 6,058

58.6 %3,462 / 5,904

57.5 %3,407 / 5,921

60.3 %3,583 / 5,945

59.6 %3,552 / 5,958

60.0 %3,628 / 6,044

57.1 %3,431 / 6,008

57.3 %3,401 / 5,935

60.2 %3,587 / 5,955

60.2 %3,781 / 6,283

58.4 %3,190 / 5,460

56.5 %3,553 / 6,284

62.0 %3,511 / 5,662

75.8 %3,821 / 5,041

62.9 %3,545 / 5,639

59.7 %3,493 / 5,854

63.2 %3,547 / 5,611

72.2 %3,839 / 5,319

65.4 %3,714 / 5,677

59.4 %3,115 / 5,245

69.8 %3,555 / 5,091

61.4 %3,471 / 5,651

68.8 %3,692 / 5,367

62.2 %3,495 / 5,622

61.4 %3,489 / 5,680

69.3 %3,731 / 5,387

65.0 %3,656 / 5,622

68.2 %3,659 / 5,364

66.2 %3,673 / 5,549

60.0 %3,582 / 5,973

3.9 %156 / 3,977

69.9 %3,575 / 5,111

80.9 %3,497 / 4,322

83.9 %3,608 / 4,300

63.4 %3,534 / 5,572

63.8 %3,555 / 5,571

57.7 %3,114 / 5,400

60.4 %3,345 / 5,539

61.1 %3,382 / 5,536

61.5 %3,474 / 5,651

60.1 %3,282 / 5,463

58.8 %3,227 / 5,486

61.9 %3,406 / 5,505

59.5 %3,324 / 5,589

59.1 %3,386 / 5,731

57.0 %3,203 / 5,623

58.7 %3,222 / 5,490

61.4 %3,385 / 5,513

59.7 %3,541 / 5,933

61.3 %3,088 / 5,037

60.4 %3,447 / 5,704

67.4 %3,408 / 5,054

79.3 %3,618 / 4,560

69.7 %3,476 / 4,988

64.7 %3,398 / 5,252

68.9 %3,469 / 5,034

74.7 %3,622 / 4,851

69.8 %3,582 / 5,129

63.7 %3,038 / 4,768

81.7 %3,538 / 4,330

66.8 %3,370 / 5,043

76.4 %3,622 / 4,739

64.6 %3,337 / 5,169

64.4 %3,356 / 5,212

73.7 %3,568 / 4,838

72.2 %3,574 / 4,950

74.8 %3,556 / 4,752

73.1 %3,598 / 4,919

63.4 %3,434 / 5,415

4.5 %207 / 4,602

66.0 %3,383 / 5,128

69.0 %3,510 / 5,084

59.6 %3,628 / 6,091

60.5 %3,654 / 6,037

57.4 %3,337 / 5,815

60.7 %3,596 / 5,920

61.8 %3,642 / 5,897

62.0 %3,724 / 6,008

59.9 %3,528 / 5,885

58.8 %3,461 / 5,885

62.0 %3,654 / 5,896

59.9 %3,574 / 5,962

59.7 %3,642 / 6,096

57.2 %3,436 / 6,012

58.7 %3,466 / 5,906

62.1 %3,652 / 5,877

60.9 %3,802 / 6,248

57.2 %3,110 / 5,439

60.6 %3,662 / 6,039

63.9 %3,558 / 5,564

67.4 %3,583 / 5,314

66.3 %3,627 / 5,473

62.0 %3,540 / 5,714

69.8 %3,695 / 5,291

65.2 %3,605 / 5,527

68.2 %3,794 / 5,562

58.4 %3,048 / 5,216

69.3 %3,496 / 5,045

64.0 %3,537 / 5,525

64.2 %3,521 / 5,482

61.1 %3,443 / 5,636

61.1 %3,466 / 5,669

65.3 %3,582 / 5,487

96.9 %4,465 / 4,610

65.4 %3,548 / 5,425

63.2 %3,548 / 5,612

63.2 %3,650 / 5,771

6.4 %242 / 3,797

92.2 %3,690 / 4,004

60.7 %3,396 / 5,599

61.1 %3,415 / 5,593

54.1 %2,956 / 5,463

56.7 %3,184 / 5,613

57.5 %3,222 / 5,606

57.7 %3,306 / 5,733

56.3 %3,123 / 5,544

55.2 %3,068 / 5,558

58.1 %3,245 / 5,587

56.0 %3,158 / 5,644

55.7 %3,229 / 5,795

54.3 %3,074 / 5,661

55.0 %3,065 / 5,572

57.6 %3,227 / 5,600

56.9 %3,394 / 5,965

61.6 %2,984 / 4,846

57.5 %3,289 / 5,720

64.2 %3,254 / 5,069

75.9 %3,467 / 4,565

66.6 %3,335 / 5,006

61.9 %3,257 / 5,258

66.3 %3,317 / 5,006

71.7 %3,479 / 4,855

67.2 %3,435 / 5,109

65.0 %2,947 / 4,536

79.5 %3,415 / 4,295

63.4 %3,210 / 5,062

73.6 %3,479 / 4,730

61.4 %3,194 / 5,200

61.4 %3,211 / 5,228

69.3 %3,381 / 4,879

68.0 %3,381 / 4,973

74.1 %3,469 / 4,681

69.3 %3,418 / 4,934

62.1 %3,325 / 5,353

4.3 %166 / 3,894

62.4 %3,499 / 5,604

62.9 %3,520 / 5,594

56.1 %3,063 / 5,458

58.8 %3,297 / 5,608

59.6 %3,338 / 5,596

59.8 %3,422 / 5,726

58.2 %3,232 / 5,554

57.4 %3,179 / 5,540

60.2 %3,360 / 5,585

58.0 %3,271 / 5,639

57.8 %3,342 / 5,786

56.2 %3,179 / 5,656

56.9 %3,173 / 5,572

59.8 %3,342 / 5,587

58.8 %3,504 / 5,963

62.9 %3,065 / 4,872

59.7 %3,398 / 5,692

67.1 %3,374 / 5,029

78.9 %3,582 / 4,541

69.6 %3,457 / 4,965

64.2 %3,362 / 5,235

69.0 %3,434 / 4,980

74.0 %3,586 / 4,845

69.9 %3,559 / 5,092

66.3 %3,027 / 4,563

82.9 %3,536 / 4,266

65.9 %3,320 / 5,038

76.7 %3,598 / 4,693

63.9 %3,302 / 5,167

63.8 %3,317 / 5,200

71.7 %3,485 / 4,860

71.2 %3,508 / 4,926

77.0 %3,586 / 4,655

71.6 %3,521 / 4,916

64.7 %3,443 / 5,321

6.5 %314 / 4,795

87.0 %4,480 / 5,147

70.6 %3,774 / 5,345

74.6 %4,032 / 5,406

75.3 %4,067 / 5,401

76.1 %4,163 / 5,474

73.3 %3,954 / 5,396

72.2 %3,895 / 5,398

75.2 %4,069 / 5,408

72.1 %3,981 / 5,524

72.1 %4,059 / 5,632

74.1 %4,000 / 5,396

71.1 %3,878 / 5,458

72.9 %4,020 / 5,512

81.0 %4,466 / 5,512

54.7 %3,154 / 5,763

52.4 %3,465 / 6,612

61.6 %3,541 / 5,753

63.2 %3,583 / 5,665

58.9 %3,491 / 5,926

58.7 %3,491 / 5,949

59.2 %3,513 / 5,933

63.6 %3,659 / 5,750

62.3 %3,710 / 5,954

55.8 %3,092 / 5,539

60.5 %3,409 / 5,639

60.0 %3,481 / 5,798

60.9 %3,545 / 5,821

84.2 %4,183 / 4,965

80.0 %4,093 / 5,119

65.3 %3,708 / 5,677

60.5 %3,605 / 5,956

59.2 %3,492 / 5,894

57.3 %3,471 / 6,059

54.2 %3,465 / 6,390

7.8 %372 / 4,765

71.4 %3,788 / 5,302

75.0 %4,037 / 5,383

76.1 %4,083 / 5,363

76.7 %4,173 / 5,444

74.0 %3,966 / 5,358

73.1 %3,912 / 5,353

76.1 %4,083 / 5,364

72.9 %3,996 / 5,484

72.6 %4,067 / 5,600

73.1 %3,955 / 5,410

71.7 %3,888 / 5,422

73.9 %4,039 / 5,462

80.4 %4,429 / 5,511

54.3 %3,169 / 5,836

53.1 %3,489 / 6,573

61.4 %3,548 / 5,775

63.8 %3,610 / 5,662

59.2 %3,508 / 5,924

58.8 %3,507 / 5,960

59.7 %3,540 / 5,925

64.0 %3,681 / 5,756

62.9 %3,740 / 5,945

55.0 %3,102 / 5,640

61.2 %3,432 / 5,609

60.5 %3,501 / 5,789

61.5 %3,564 / 5,795

83.7 %4,146 / 4,953

81.0 %4,106 / 5,071

66.3 %3,729 / 5,627

61.6 %3,635 / 5,900

59.7 %3,512 / 5,882

57.8 %3,498 / 6,053

54.9 %3,490 / 6,358

6.5 %275 / 4,255

85.8 %4,083 / 4,758

87.9 %4,148 / 4,719

87.3 %4,210 / 4,821

84.3 %4,000 / 4,745

83.2 %3,951 / 4,746

87.2 %4,129 / 4,735

83.0 %4,039 / 4,866

82.1 %4,091 / 4,983

76.5 %3,812 / 4,986

80.1 %3,883 / 4,849

80.9 %3,994 / 4,935

76.9 %4,082 / 5,311

48.8 %2,769 / 5,670

48.9 %3,123 / 6,387

55.2 %3,117 / 5,651

57.8 %3,168 / 5,483

54.4 %3,115 / 5,722

53.0 %3,084 / 5,821

54.1 %3,109 / 5,744

57.2 %3,219 / 5,627

56.4 %3,282 / 5,818

49.4 %2,697 / 5,463

56.7 %3,055 / 5,387

54.9 %3,093 / 5,638

54.9 %3,108 / 5,657

69.8 %3,524 / 5,052

70.1 %3,564 / 5,086

60.2 %3,304 / 5,491

58.3 %3,313 / 5,682

54.1 %3,087 / 5,708

52.8 %3,098 / 5,864

50.5 %3,112 / 6,159

6.5 %297 / 4,585

92.4 %4,420 / 4,782

93.1 %4,510 / 4,846

90.9 %4,321 / 4,752

89.3 %4,258 / 4,766

91.4 %4,391 / 4,802

86.7 %4,286 / 4,946

86.2 %4,354 / 5,052

82.5 %4,123 / 4,999

87.2 %4,217 / 4,835

86.4 %4,284 / 4,956

82.3 %4,384 / 5,324

50.5 %2,949 / 5,843

52.0 %3,369 / 6,481

58.1 %3,351 / 5,768

60.8 %3,408 / 5,604

57.4 %3,344 / 5,830

55.9 %3,316 / 5,935

57.0 %3,342 / 5,868

60.7 %3,469 / 5,718

59.2 %3,512 / 5,930

50.9 %2,875 / 5,643

58.0 %3,242 / 5,586

57.5 %3,317 / 5,768

58.0 %3,347 / 5,771

73.7 %3,780 / 5,130

73.6 %3,809 / 5,175

62.8 %3,533 / 5,624

61.7 %3,572 / 5,787

56.6 %3,311 / 5,848

55.9 %3,339 / 5,968

53.2 %3,345 / 6,285

6.5 %299 / 4,615

93.8 %4,543 / 4,844

90.6 %4,329 / 4,776

89.6 %4,280 / 4,777

92.6 %4,436 / 4,791

87.8 %4,330 / 4,934

87.4 %4,401 / 5,037

82.8 %4,146 / 5,009

86.4 %4,213 / 4,877

87.4 %4,324 / 4,949

83.2 %4,427 / 5,320

51.2 %2,989 / 5,836

52.5 %3,402 / 6,480

59.1 %3,394 / 5,744

61.6 %3,449 / 5,602

58.0 %3,382 / 5,829

56.6 %3,354 / 5,923

57.6 %3,378 / 5,868

61.4 %3,510 / 5,718

60.0 %3,556 / 5,925

51.8 %2,916 / 5,632

58.8 %3,280 / 5,578

58.4 %3,356 / 5,750

58.7 %3,387 / 5,767

74.4 %3,815 / 5,127

74.7 %3,853 / 5,159

63.6 %3,573 / 5,615

62.8 %3,618 / 5,764

57.2 %3,345 / 5,850

56.7 %3,382 / 5,960

53.9 %3,383 / 6,279

6.9 %329 / 4,769

90.2 %4,398 / 4,874

89.1 %4,343 / 4,876

93.4 %4,532 / 4,853

88.5 %4,432 / 5,009

88.3 %4,506 / 5,102

82.4 %4,209 / 5,105

86.2 %4,286 / 4,972

87.8 %4,414 / 5,029

84.4 %4,532 / 5,370

51.4 %3,067 / 5,966

52.8 %3,484 / 6,602

59.4 %3,476 / 5,850

61.7 %3,532 / 5,721

58.4 %3,467 / 5,936

57.0 %3,439 / 6,035

57.8 %3,462 / 5,991

61.8 %3,593 / 5,814

60.5 %3,642 / 6,024

51.8 %2,991 / 5,774

59.0 %3,365 / 5,707

58.6 %3,439 / 5,864

58.9 %3,470 / 5,892

74.7 %3,901 / 5,221

75.7 %3,963 / 5,232

64.0 %3,661 / 5,718

62.9 %3,699 / 5,877

57.4 %3,428 / 5,971

56.9 %3,464 / 6,093

54.1 %3,467 / 6,408

6.6 %296 / 4,483

92.3 %4,283 / 4,642

91.7 %4,353 / 4,745

87.1 %4,254 / 4,883

86.4 %4,318 / 5,000

84.2 %4,126 / 4,901

88.9 %4,216 / 4,742

86.6 %4,246 / 4,901

80.3 %4,290 / 5,341

49.8 %2,883 / 5,784

51.3 %3,294 / 6,424

57.4 %3,282 / 5,722

60.2 %3,340 / 5,544

56.7 %3,276 / 5,782

54.9 %3,242 / 5,901

56.4 %3,275 / 5,807

59.9 %3,400 / 5,674

58.5 %3,444 / 5,890

50.3 %2,810 / 5,581

57.6 %3,184 / 5,523

56.8 %3,247 / 5,715

57.5 %3,283 / 5,714

73.3 %3,727 / 5,084

73.3 %3,757 / 5,127

62.2 %3,468 / 5,578

61.1 %3,509 / 5,747

56.1 %3,247 / 5,789

55.4 %3,272 / 5,910

52.7 %3,279 / 6,221

6.5 %289 / 4,438

90.3 %4,293 / 4,754

86.1 %4,206 / 4,883

85.0 %4,257 / 5,007

83.4 %4,084 / 4,894

87.5 %4,158 / 4,753

84.8 %4,176 / 4,925

79.1 %4,230 / 5,350

48.9 %2,833 / 5,788

50.2 %3,240 / 6,455

56.4 %3,232 / 5,730

59.0 %3,286 / 5,566

55.5 %3,220 / 5,801

53.9 %3,187 / 5,912

55.3 %3,224 / 5,825

58.8 %3,346 / 5,686

57.3 %3,383 / 5,907

49.6 %2,766 / 5,578

56.6 %3,129 / 5,524

55.9 %3,199 / 5,721

56.4 %3,231 / 5,727

72.3 %3,674 / 5,081

72.2 %3,702 / 5,124

61.4 %3,420 / 5,569

59.9 %3,441 / 5,748

55.0 %3,191 / 5,798

54.3 %3,218 / 5,922

51.7 %3,226 / 6,237

6.5 %300 / 4,609

88.9 %4,360 / 4,903

88.8 %4,441 / 5,001

82.8 %4,146 / 5,007

86.8 %4,221 / 4,862

87.6 %4,336 / 4,951

82.7 %4,413 / 5,333

51.6 %3,004 / 5,824

52.9 %3,420 / 6,467

59.4 %3,403 / 5,731

62.3 %3,472 / 5,575

58.5 %3,402 / 5,811

56.9 %3,367 / 5,918

58.1 %3,402 / 5,852

61.4 %3,511 / 5,718

60.5 %3,573 / 5,910

52.2 %2,931 / 5,618

59.4 %3,305 / 5,564

58.8 %3,370 / 5,732

58.8 %3,393 / 5,769

74.7 %3,824 / 5,118

75.1 %3,864 / 5,147

64.2 %3,586 / 5,587

63.1 %3,635 / 5,758

57.7 %3,367 / 5,834

57.1 %3,396 / 5,948

54.4 %3,403 / 6,261

6.6 %304 / 4,640

90.6 %4,482 / 4,947

80.7 %4,103 / 5,084

84.7 %4,182 / 4,938

83.4 %4,237 / 5,083

79.0 %4,320 / 5,466

48.8 %2,927 / 5,994

51.1 %3,340 / 6,537

56.9 %3,320 / 5,838

59.8 %3,382 / 5,656

56.1 %3,315 / 5,904

54.4 %3,282 / 6,038

56.0 %3,322 / 5,937

58.7 %3,423 / 5,834

58.2 %3,492 / 5,998

49.5 %2,860 / 5,774

57.3 %3,219 / 5,621

56.3 %3,286 / 5,832

56.6 %3,310 / 5,844

71.4 %3,736 / 5,233

72.6 %3,800 / 5,231

61.4 %3,497 / 5,698

60.9 %3,552 / 5,828

55.8 %3,286 / 5,893

55.1 %3,315 / 6,017

52.7 %3,329 / 6,321

8.1 %389 / 4,774

79.3 %4,143 / 5,222

82.6 %4,205 / 5,092

83.3 %4,315 / 5,181

78.8 %4,386 / 5,567

49.7 %2,992 / 6,023

51.2 %3,415 / 6,674

56.4 %3,385 / 6,004

59.4 %3,450 / 5,808

55.7 %3,379 / 6,061

54.7 %3,364 / 6,152

55.8 %3,390 / 6,077

58.6 %3,493 / 5,958

58.4 %3,570 / 6,108

50.1 %2,922 / 5,832

57.1 %3,288 / 5,763

55.9 %3,350 / 5,994

56.2 %3,371 / 5,996

71.0 %3,804 / 5,355

72.5 %3,876 / 5,343

61.0 %3,561 / 5,842

60.5 %3,616 / 5,981

55.5 %3,351 / 6,036

54.8 %3,380 / 6,171

52.7 %3,402 / 6,461

7.1 %319 / 4,516

84.8 %4,128 / 4,867

80.4 %4,112 / 5,115

84.0 %4,405 / 5,246

48.3 %2,838 / 5,881

49.2 %3,232 / 6,565

54.8 %3,216 / 5,873

57.5 %3,272 / 5,695

53.5 %3,188 / 5,963

53.2 %3,188 / 5,988

54.4 %3,225 / 5,932

57.2 %3,333 / 5,824

56.1 %3,383 / 6,028

48.6 %2,762 / 5,683

55.0 %3,114 / 5,660

54.3 %3,187 / 5,864

55.1 %3,226 / 5,850

73.5 %3,759 / 5,115

70.4 %3,694 / 5,244

59.2 %3,379 / 5,708

58.1 %3,416 / 5,875

53.8 %3,188 / 5,921

53.1 %3,211 / 6,045

50.9 %3,230 / 6,348

6.4 %286 / 4,461

83.6 %4,156 / 4,971

79.4 %4,249 / 5,349

48.5 %2,829 / 5,829

50.3 %3,247 / 6,451

55.9 %3,221 / 5,759

58.8 %3,276 / 5,569

55.2 %3,213 / 5,816

53.7 %3,188 / 5,932

55.3 %3,223 / 5,828

58.4 %3,335 / 5,707

57.2 %3,383 / 5,918

49.0 %2,758 / 5,625

56.2 %3,121 / 5,550

55.5 %3,190 / 5,746

56.2 %3,225 / 5,743

71.5 %3,664 / 5,124

72.5 %3,717 / 5,126

60.8 %3,403 / 5,599

59.7 %3,446 / 5,768

54.6 %3,182 / 5,824

54.3 %3,216 / 5,926

51.9 %3,231 / 6,231

6.8 %317 / 4,648

79.7 %4,358 / 5,467

51.5 %2,993 / 5,815

52.5 %3,408 / 6,495

59.3 %3,413 / 5,760

61.2 %3,443 / 5,628

58.1 %3,398 / 5,844

56.0 %3,340 / 5,963

57.9 %3,394 / 5,866

61.5 %3,523 / 5,724

60.1 %3,574 / 5,944

51.8 %2,917 / 5,634

58.9 %3,284 / 5,574

58.6 %3,376 / 5,758

60.1 %3,431 / 5,707

72.3 %3,777 / 5,221

72.2 %3,799 / 5,260

63.6 %3,573 / 5,615

63.2 %3,629 / 5,743

57.3 %3,352 / 5,850

57.2 %3,399 / 5,942

53.8 %3,387 / 6,290

7.1 %360 / 5,105

51.6 %3,150 / 6,107

51.7 %3,553 / 6,874

56.9 %3,518 / 6,184

60.1 %3,607 / 6,001

56.0 %3,510 / 6,268

56.2 %3,511 / 6,247

57.0 %3,552 / 6,236

60.2 %3,670 / 6,100

59.2 %3,730 / 6,299

51.6 %3,058 / 5,925

57.5 %3,429 / 5,968

56.5 %3,490 / 6,176

57.9 %3,562 / 6,151

78.8 %4,169 / 5,288

75.9 %4,112 / 5,417

62.4 %3,729 / 5,980

61.7 %3,775 / 6,118

56.6 %3,520 / 6,218

55.8 %3,542 / 6,350

53.1 %3,543 / 6,670

5.1 %188 / 3,667

51.1 %3,044 / 5,957

54.1 %3,022 / 5,587

58.1 %3,107 / 5,347

56.1 %3,027 / 5,398

54.6 %3,014 / 5,522

59.4 %3,045 / 5,125

59.5 %3,137 / 5,270

58.9 %3,158 / 5,363

84.3 %3,284 / 3,896

62.0 %3,017 / 4,864

54.5 %3,006 / 5,516

58.8 %3,075 / 5,231

54.9 %2,969 / 5,412

54.9 %2,979 / 5,422

57.2 %3,076 / 5,378

58.6 %3,101 / 5,296

56.2 %3,061 / 5,445

56.7 %3,096 / 5,457

54.6 %3,041 / 5,572

5.3 %261 / 4,953

60.7 %3,579 / 5,892

58.6 %3,444 / 5,876

70.3 %3,877 / 5,516

63.7 %3,738 / 5,870

61.6 %3,562 / 5,785

59.1 %3,537 / 5,983

59.3 %3,614 / 6,093

51.9 %2,984 / 5,755

60.2 %3,384 / 5,624

60.9 %3,560 / 5,846

58.9 %3,472 / 5,897

53.0 %3,281 / 6,191

53.0 %3,301 / 6,231

55.9 %3,399 / 6,081

62.1 %3,660 / 5,892

57.2 %3,417 / 5,972

54.8 %3,399 / 6,199

84.8 %4,469 / 5,272

5.0 %218 / 4,327

66.4 %3,437 / 5,176

69.3 %3,613 / 5,210

65.0 %3,548 / 5,458

64.3 %3,449 / 5,364

64.2 %3,476 / 5,418

62.9 %3,521 / 5,599

55.8 %2,981 / 5,342

66.3 %3,324 / 5,013

90.5 %4,101 / 4,529

64.4 %3,440 / 5,345

61.3 %3,320 / 5,415

60.9 %3,330 / 5,467

66.8 %3,514 / 5,264

64.5 %3,512 / 5,446

63.7 %3,397 / 5,331

59.9 %3,350 / 5,593

63.4 %3,574 / 5,635

4.0 %165 / 4,143

68.8 %3,521 / 5,119

64.0 %3,453 / 5,399

68.2 %3,516 / 5,157

79.5 %3,829 / 4,816

71.2 %3,690 / 5,180

60.6 %3,062 / 5,055

76.9 %3,505 / 4,558

66.0 %3,404 / 5,157

73.2 %3,615 / 4,941

64.6 %3,387 / 5,240

64.3 %3,402 / 5,288

74.7 %3,658 / 4,895

69.6 %3,583 / 5,148

72.8 %3,563 / 4,893

71.3 %3,605 / 5,058

62.4 %3,471 / 5,559

5.1 %221 / 4,371

73.9 %3,806 / 5,150

70.1 %3,607 / 5,145

69.3 %3,629 / 5,233

68.9 %3,702 / 5,371

58.1 %2,988 / 5,139

69.7 %3,435 / 4,926

68.9 %3,580 / 5,195

67.5 %3,517 / 5,207

59.9 %3,308 / 5,518

59.9 %3,325 / 5,554

65.2 %3,477 / 5,336

68.1 %3,626 / 5,321

66.0 %3,478 / 5,267

62.5 %3,447 / 5,517

71.4 %3,828 / 5,360

6.0 %268 / 4,451

64.9 %3,515 / 5,412

65.7 %3,574 / 5,444

63.9 %3,601 / 5,632

56.5 %2,973 / 5,261

64.7 %3,352 / 5,182

64.7 %3,521 / 5,438

62.0 %3,427 / 5,525

58.5 %3,289 / 5,625

58.0 %3,298 / 5,687

61.8 %3,434 / 5,555

63.6 %3,538 / 5,561

61.2 %3,394 / 5,549

57.6 %3,350 / 5,811

64.8 %3,686 / 5,687

5.6 %236 / 4,244

67.7 %3,578 / 5,285

68.9 %3,677 / 5,337

61.0 %2,994 / 4,905

69.7 %3,424 / 4,912

64.7 %3,433 / 5,308

67.6 %3,519 / 5,205

61.0 %3,341 / 5,479

60.7 %3,356 / 5,526

64.6 %3,484 / 5,390

71.7 %3,693 / 5,152

66.8 %3,500 / 5,241

62.4 %3,415 / 5,472

64.1 %3,552 / 5,544

5.3 %230 / 4,376

69.9 %3,734 / 5,345

60.9 %3,077 / 5,051

71.3 %3,490 / 4,896

63.5 %3,435 / 5,412

71.5 %3,666 / 5,130

64.0 %3,448 / 5,389

64.0 %3,467 / 5,420

71.0 %3,683 / 5,190

67.1 %3,604 / 5,370

69.9 %3,617 / 5,178

66.5 %3,589 / 5,395

62.6 %3,555 / 5,675

5.0 %233 / 4,632

59.7 %3,081 / 5,164

68.1 %3,491 / 5,124

62.6 %3,490 / 5,571

66.8 %3,602 / 5,393

63.0 %3,508 / 5,571

62.8 %3,526 / 5,611

65.0 %3,582 / 5,511

68.1 %3,733 / 5,483

67.3 %3,625 / 5,383

61.8 %3,515 / 5,688

62.5 %3,636 / 5,813

4.0 %138 / 3,456

64.5 %2,971 / 4,604

55.5 %2,945 / 5,304

59.9 %3,016 / 5,032

55.5 %2,893 / 5,215

55.5 %2,904 / 5,230

58.4 %3,008 / 5,147

60.2 %3,047 / 5,065

58.2 %3,005 / 5,166

57.4 %3,041 / 5,298

56.1 %2,996 / 5,336

4.3 %165 / 3,851

68.7 %3,364 / 4,900

77.1 %3,582 / 4,648

64.6 %3,288 / 5,088

64.3 %3,300 / 5,132

73.5 %3,505 / 4,769

71.5 %3,495 / 4,886

78.1 %3,576 / 4,581

70.2 %3,462 / 4,932

64.6 %3,415 / 5,283

4.9 %211 / 4,271

66.6 %3,481 / 5,229

63.3 %3,354 / 5,302

62.9 %3,366 / 5,354

68.8 %3,549 / 5,155

64.6 %3,492 / 5,407

66.0 %3,442 / 5,219

59.9 %3,330 / 5,557

63.8 %3,556 / 5,574

5.7 %243 / 4,240

64.4 %3,419 / 5,309

64.4 %3,438 / 5,336

72.1 %3,650 / 5,061

66.1 %3,521 / 5,323

75.5 %3,719 / 4,929

68.6 %3,593 / 5,240

62.3 %3,502 / 5,625

5.9 %253 / 4,264

91.8 %4,114 / 4,480

69.1 %3,576 / 5,175

62.3 %3,426 / 5,495

63.0 %3,371 / 5,349

58.6 %3,297 / 5,625

55.1 %3,282 / 5,957

6.1 %263 / 4,322

69.7 %3,616 / 5,188

62.4 %3,449 / 5,530

62.8 %3,388 / 5,393

58.7 %3,317 / 5,653

55.1 %3,299 / 5,991

4.2 %183 / 4,350

66.5 %3,557 / 5,349

72.1 %3,625 / 5,025

65.6 %3,517 / 5,360

59.0 %3,411 / 5,784

4.4 %198 / 4,465

66.3 %3,514 / 5,302

64.9 %3,541 / 5,459

64.9 %3,649 / 5,620

3.7 %156 / 4,271

66.5 %3,514 / 5,281

61.4 %3,464 / 5,645

4.5 %201 / 4,458

58.0 %3,422 / 5,900

4.6 %216 / 4,733

Shigella dysenteriae Sd197


Shigella boydii Sb227


Shigella sonnei Ss046


Escherichia coli HS


Escherichia coli E24377A


Escherichia coli B7A


Escherichia coli F11


Escherichia coli E22




Escherichia coli B171


Shigella boydii

CDC 3083-94


Escherichia coli 53638


Escherichia coli 101-1


Shigella dysenteriae 1012




Escherichia coli UTI89


Escherichia coli

K12 W3110


Shigella flexneri 5 str. 8401


Escherichia coli A

PECO1


Escherichia coli SE11


Escherichia coli A

TCC8739


Escherichia coli SM

S3-3-5


Escherichia coli

K12 DH

10B


Escherichia coli

K12 MG

1655


Escherichia coli

0157:H7 str. Sakai


Escherichia coli

0157:H str. ED

L933


Escherichia coli

0157:H str. EC4045


Escherichia coli

0157:H str. EC4206


Escherichia coli

0157:H str. EC4042


Escherichia coli

0157:H str. EC4115


Escherichia coli

0157:H str. EC4196


Escherichia coli

0157:H str. EC4113


Escherichia coli

0157:H str. EC4076


Escherichia coli

0157:H str. EC4401


Escherichia coli

0157:H str. EC4486


Escherichia coli

0157:H str. EC4501


Escherichia coli

0157:H str. EC508


Escherichia coli

0157:H str. EC869


Escherichia coli

0157:H TW

14588


Shigella flexneri 2a str. 301


Escherichia coli CFT073


Escherichia coli

0127:H6 str. E2348/69


Escherichia coli IAI1


Escherichia coli S88


Escherichia coli ED1a






Escherichia coli U

MN

026


Shigella flexneri

2a str. 2457T






Escherichia coli EcH

10407


Escherichia coli

LAN

L ECA


Escherichia coli

LAN

L ECF


Escherichia coli O

103 Oslo


Escherichia coli

SECEC SMS35


Escherichia coli VR50


Escherichia coli

DSM

172521


Escherichia coli

Nissle 1917


Shige

lla d

ysen

teriae

Sd19

7

4,50

5 pro

tein

s, 3,

374

fam

ilies

Shige

lla bo

ydii

Sb22

7

4,28

4 pro

tein

s, 3,

474

fam

ilies

Shige

lla so

nnei

Ss0

46

4,47

5 pro

tein

s, 3,

730

fam

ilies

Esche

richi

a coli

HS

4,38

4 pro

tein

s, 4,

125

fam

ilies

Esche

richi

a coli

E24

377A

4,99

7 pro

tein

s, 4,

611

fam

ilies

Esche

richi

a coli

B7A

4,64

8 pro

tein

s, 4,

340

fam

ilies

Esche

richi

a coli

F11

4,70

4 pro

tein

s, 4,

393

fam

ilies

Esche

richi

a coli

E22

5,10

5 pro

tein

s, 4,

684

fam

ilies

Esche

richi

a coli

E11

0019

4,93

4 pro

tein

s, 4,

419

fam

ilies

Esche

richi

a coli

B17

1

5,01

0 pro

tein

s, 4,

482

fam

ilies

Shige

lla bo

ydii

CD

C 308

3-94

4,55

7 pro

tein

s, 3,

700

fam

ilies

Esche

richi

a coli

536

38

5,17

2 pro

tein

s, 4,

610

fam

ilies

Esche

richi

a coli

101

-1

4,60

7 pro

tein

s, 4,

299

fam

ilies

Shige

lla d

ysen

teriae

101

2

4,41

9 pro

tein

s, 3,

895

fam

ilies

Esche

richi

a coli

536

4,62

9 pro

tein

s, 4,

335

fam

ilies

Esche

richi

a coli

UTI8

9

5,21

1 pro

tein

s, 4,

894

fam

ilies

Esche

richi

a coli

K12

W31

10

4,22

6 pro

tein

s, 3,

965

fam

ilies

Shige

lla fl

exner

i

5 st

r. 84

01

4,11

6 pro

tein

s, 3,

502

fam

ilies

Esche

richi

a coli

APECO

1

4,89

0 pro

tein

s, 4,

559

fam

ilies

Esche

richi

a coli

SE11

5,00

2 pro

tein

s, 4,

663

fam

ilies

Esche

richi

a coli

ATCC87

39

4,20

0 pro

tein

s, 3,

977

fam

ilies

Esche

richi

a coli

SM

S3-3

-5

4,91

3 pro

tein

s, 4,

602

fam

ilies

Esche

richi

a coli

K12

DH

10B

4,12

6 pro

tein

s, 3,

797

fam

ilies

Esche

richi

a coli

K12

MG

1655

4,13

1 pro

tein

s, 3,

894

fam

ilies

Esche

richi

a coli

015

7:H

7 st

r. Sa

kai

5,44

7 pro

tein

s, 4,

795

fam

ilies

Esche

richi

a coli

015

7:H

str.

EDL93

3

5,44

9 pro

tein

s, 4,

765

fam

ilies

Esche

richi

a coli

015

7:H

str.

EC4045

4,78

1 pro

tein

s, 4,

255

fam

ilies

Esche

richi

a coli

015

7:H

str.

EC4206

5,20

2 pro

tein

s, 4,

585

fam

ilies

Esche

richi

a coli

015

7:H

str.

EC4042

5,23

2 pro

tein

s, 4,

615

fam

ilies

Esche

richi

a coli

015

7:H

str.

EC4115

5,47

7 pro

tein

s, 4,

769

fam

ilies

Esche

richi

a coli

015

7:H

str.

EC4196

5,07

2 pro

tein

s, 4,

483

fam

ilies

Esche

richi

a coli

015

7:H

str.

EC4113

5,00

5 pro

tein

s, 4,

438

fam

ilies

Esche

richi

a coli

015

7:H

str.

EC4076

5,24

2 pro

tein

s, 4,

609

fam

ilies

Esche

richi

a coli

015

7:H

str.

EC4401

5,18

5 pro

tein

s, 4,

640

fam

ilies

Esche

richi

a coli

015

7:H

str.

EC4486

5,42

9 pro

tein

s, 4,

774

fam

ilies

Esche

richi

a coli

015

7:H

str.

EC4501

5,12

4 pro

tein

s, 4,

516

fam

ilies

Esche

richi

a coli

015

7:H

str.

EC508

5,01

9 pro

tein

s, 4,

461

fam

ilies

Esche

richi

a coli

015

7:H

str.

EC869

5,22

0 pro

tein

s, 4,

648

fam

ilies

Esche

richi

a coli

015

7:H

TW

1458

8

5,80

3 pro

tein

s, 5,

105

fam

ilies

Shige

lla fl

exner

i

2a

str.

301

4,44

5 pro

tein

s, 3,

667

fam

ilies

Esche

richi

a coli

CFT07

3

5,37

9 pro

tein

s, 4,

953

fam

ilies

Esche

richi

a coli

012

7:H

6 st

r. E23

48/69

4,65

3 pro

tein

s, 4,

327

fam

ilies

Esche

richi

a coli

IAI1

4,35

4 pro

tein

s, 4,

143

fam

ilies

Esche

richi

a coli

S88

4,69

6 pro

tein

s, 4,

371

fam

ilies

Esche

richi

a coli

ED

1a

4,91

5 pro

tein

s, 4,

451

fam

ilies

Esche

richi

a coli

IAI3

9

4,73

2 pro

tein

s, 4,

244

fam

ilies

Esche

richi

a coli

559

89

4,76

3 pro

tein

s, 4,

376

fam

ilies

Esche

richi

a coli

UM

N02

6

4,96

8 pro

tein

s, 4,

632

fam

ilies

Shige

lla fl

exner

i

2a

str.

2457

T

4,06

8 pro

tein

s, 3,

456

fam

ilies

Esche

richi

a coli

B03

4,07

6 pro

tein

s, 3,

851

fam

ilies

Esche

richi

a coli

E23

48

4,59

2 pro

tein

s, 4,

271

fam

ilies

Esche

richi

a coli

EcH

1040

7

4,61

2 pro

tein

s, 4,

240

fam

ilies

Esche

richi

a coli

LA

NL E

CA

4,75

0 pro

tein

s, 4,

264

fam

ilies

Esche

richi

a coli

LA

NL E

CF

4,81

3 pro

tein

s, 4,

322

fam

ilies

Esche

richi

a coli

O10

3 O

slo

4,57

1 pro

tein

s, 4,

350

fam

ilies

Esche

richi

a coli

SECEC S

MS3

5

4,74

3 pro

tein

s, 4,

465

fam

ilies

Esche

richi

a coli

VR50

4,45

3 pro

tein

s, 4,

271

fam

ilies

Esche

richi

a coli

DSM

1725

21

4,71

1 pro

tein

s, 4,

458

fam

ilies

Esche

richi

a coli

Niss

le 1

917

5,05

3 pro

tein

s, 4,

733

fam

ilies

3.4 %115 / 3,374

58.0 %2,701 / 4,658

61.8 %2,839 / 4,591

49.7 %2,766 / 5,563

50.9 %2,836 / 5,575

45.7 %2,612 / 5,711

43.6 %2,693 / 6,173

40.9 %2,701 / 6,596

44.2 %2,690 / 6,088

45.5 %2,668 / 5,870

53.7 %2,692 / 5,010

51.5 %2,845 / 5,526

46.3 %2,700 / 5,832

49.5 %2,575 / 5,203

47.1 %2,796 / 5,931

47.9 %2,844 / 5,942

53.8 %2,818 / 5,236

58.9 %2,667 / 4,528

45.5 %2,650 / 5,823

50.7 %2,865 / 5,655

51.8 %2,803 / 5,416

49.3 %2,869 / 5,821

53.0 %2,740 / 5,169

53.9 %2,801 / 5,197

50.5 %2,947 / 5,837

49.2 %2,952 / 5,995

42.7 %2,581 / 6,049

43.9 %2,748 / 6,260

44.8 %2,794 / 6,243

44.8 %2,865 / 6,401

43.1 %2,682 / 6,216

42.7 %2,642 / 6,190

45.0 %2,810 / 6,240

42.7 %2,740 / 6,411

43.4 %2,792 / 6,438

41.9 %2,638 / 6,301

42.0 %2,629 / 6,257

44.6 %2,787 / 6,252

47.1 %2,930 / 6,218

61.1 %2,759 / 4,518

44.9 %2,794 / 6,224

49.0 %2,804 / 5,726

48.7 %2,825 / 5,799

51.4 %2,812 / 5,471

50.1 %2,789 / 5,565

50.4 %2,803 / 5,558

52.0 %2,838 / 5,456

50.0 %2,886 / 5,771

59.8 %2,636 / 4,405

52.8 %2,752 / 5,215

48.8 %2,776 / 5,685

48.8 %2,791 / 5,714

47.5 %2,762 / 5,813

47.7 %2,778 / 5,828

48.0 %2,791 / 5,816

50.4 %2,861 / 5,681

47.1 %2,768 / 5,876

49.8 %2,800 / 5,622

50.9 %2,831 / 5,559

3.6 %126 / 3,474

68.1 %3,014 / 4,429

58.3 %3,014 / 5,171

55.2 %3,044 / 5,517

54.0 %2,880 / 5,335

51.1 %2,879 / 5,631

49.7 %2,975 / 5,991

55.2 %2,960 / 5,363

51.6 %2,905 / 5,632

68.5 %2,981 / 4,352

57.7 %3,104 / 5,379

56.6 %2,955 / 5,225

55.7 %2,736 / 4,913

54.5 %2,969 / 5,444

53.2 %3,066 / 5,763

62.1 %3,047 / 4,910

66.9 %2,838 / 4,239

51.2 %2,868 / 5,603

58.1 %3,140 / 5,409

62.5 %3,070 / 4,912

57.1 %3,080 / 5,391

60.5 %2,934 / 4,848

62.2 %3,024 / 4,865

54.3 %3,101 / 5,710

54.3 %3,103 / 5,710

49.7 %2,734 / 5,497

51.4 %2,922 / 5,682

52.3 %2,964 / 5,664

52.2 %3,036 / 5,814

50.8 %2,861 / 5,634

50.1 %2,816 / 5,617

52.6 %2,980 / 5,661

49.0 %2,890 / 5,902

50.4 %2,963 / 5,878

48.7 %2,796 / 5,742

49.2 %2,799 / 5,688

52.9 %2,984 / 5,644

50.4 %3,073 / 6,099

65.0 %2,884 / 4,440

51.8 %3,027 / 5,842

55.5 %3,036 / 5,466

58.1 %3,069 / 5,286

57.4 %3,035 / 5,290

55.4 %3,019 / 5,450

58.9 %3,019 / 5,124

58.0 %3,092 / 5,334

56.5 %3,073 / 5,440

63.6 %2,813 / 4,420

63.0 %2,998 / 4,757

56.1 %3,012 / 5,369

59.0 %3,037 / 5,144

55.3 %2,910 / 5,262

55.8 %2,939 / 5,264

57.6 %3,079 / 5,342

58.6 %3,072 / 5,246

55.1 %2,992 / 5,429

56.4 %3,054 / 5,416

54.7 %3,020 / 5,520

4.6 %172 / 3,730

61.3 %3,171 / 5,172

60.7 %3,276 / 5,401

56.0 %3,053 / 5,452

53.2 %3,040 / 5,711

53.0 %3,163 / 5,963

57.4 %3,122 / 5,439

55.1 %3,091 / 5,614

61.5 %2,951 / 4,795

62.1 %3,267 / 5,264

59.2 %3,119 / 5,270

58.4 %2,880 / 4,929

56.0 %3,126 / 5,585

54.9 %3,204 / 5,836

66.4 %3,223 / 4,852

66.8 %2,994 / 4,485

52.7 %3,009 / 5,714

61.1 %3,332 / 5,455

66.3 %3,228 / 4,866

59.2 %3,232 / 5,456

65.0 %3,115 / 4,790

66.8 %3,205 / 4,795

57.6 %3,277 / 5,690

57.7 %3,286 / 5,691

52.0 %2,874 / 5,529

54.1 %3,073 / 5,678

54.8 %3,113 / 5,677

55.0 %3,192 / 5,805

53.3 %3,003 / 5,629

52.5 %2,959 / 5,635

55.3 %3,130 / 5,662

51.7 %3,057 / 5,908

52.9 %3,117 / 5,891

51.2 %2,942 / 5,750

51.7 %2,943 / 5,691

54.8 %3,121 / 5,700

53.8 %3,258 / 6,053

67.6 %3,052 / 4,514

53.2 %3,136 / 5,892

55.4 %3,127 / 5,643

63.1 %3,285 / 5,203

58.5 %3,168 / 5,412

57.1 %3,139 / 5,496

61.9 %3,159 / 5,101

62.3 %3,283 / 5,266

62.7 %3,307 / 5,272

66.0 %2,925 / 4,435

66.7 %3,132 / 4,695

55.6 %3,103 / 5,580

62.1 %3,204 / 5,158

58.3 %3,073 / 5,272

58.3 %3,085 / 5,289

61.3 %3,228 / 5,266

60.2 %3,206 / 5,330

60.1 %3,190 / 5,312

58.8 %3,230 / 5,496

56.2 %3,149 / 5,603

3.3 %137 / 4,125

70.8 %3,686 / 5,208

63.7 %3,360 / 5,277

60.3 %3,283 / 5,443

62.1 %3,485 / 5,611

62.9 %3,420 / 5,435

60.2 %3,366 / 5,596

54.3 %2,929 / 5,394

63.7 %3,533 / 5,545

65.6 %3,395 / 5,173

53.2 %2,943 / 5,537

63.9 %3,379 / 5,288

61.1 %3,488 / 5,708

75.6 %3,531 / 4,670

61.1 %3,045 / 4,983

57.3 %3,234 / 5,644

69.9 %3,671 / 5,255

77.5 %3,572 / 4,612

65.7 %3,528 / 5,366

72.7 %3,385 / 4,659

75.8 %3,503 / 4,621

57.7 %3,421 / 5,929

58.6 %3,460 / 5,907

53.7 %3,063 / 5,702

56.3 %3,297 / 5,853

57.1 %3,337 / 5,842

57.1 %3,418 / 5,981

55.7 %3,231 / 5,798

54.8 %3,177 / 5,795

57.6 %3,357 / 5,832

55.6 %3,278 / 5,891

55.4 %3,338 / 6,029

53.2 %3,157 / 5,930

54.6 %3,176 / 5,820

57.2 %3,336 / 5,828

56.4 %3,496 / 6,197

58.2 %3,031 / 5,209

58.3 %3,444 / 5,906

62.4 %3,336 / 5,350

74.5 %3,579 / 4,805

66.4 %3,462 / 5,212

60.8 %3,347 / 5,505

64.3 %3,399 / 5,287

70.3 %3,582 / 5,092

63.7 %3,476 / 5,461

61.0 %2,989 / 4,902

75.3 %3,460 / 4,597

61.8 %3,300 / 5,337

69.6 %3,517 / 5,054

59.2 %3,241 / 5,477

59.1 %3,256 / 5,513

68.2 %3,498 / 5,131

67.8 %3,528 / 5,202

69.6 %3,501 / 5,029

68.7 %3,555 / 5,173

62.1 %3,453 / 5,563

5.0 %232 / 4,611

65.7 %3,604 / 5,483

59.4 %3,413 / 5,747

63.1 %3,686 / 5,846

63.4 %3,601 / 5,676

62.9 %3,604 / 5,732

53.0 %3,020 / 5,703

62.4 %3,636 / 5,830

65.3 %3,568 / 5,468

52.9 %3,070 / 5,807

61.2 %3,469 / 5,670

59.1 %3,588 / 6,072

68.8 %3,566 / 5,180

58.0 %3,110 / 5,362

55.0 %3,330 / 6,056

71.0 %3,903 / 5,495

68.5 %3,564 / 5,203

64.3 %3,655 / 5,684

66.4 %3,428 / 5,163

68.8 %3,536 / 5,142

57.6 %3,574 / 6,205

58.5 %3,607 / 6,164

54.6 %3,244 / 5,945

57.4 %3,483 / 6,066

58.1 %3,522 / 6,060

58.3 %3,600 / 6,180

56.5 %3,414 / 6,041

55.7 %3,358 / 6,034

58.4 %3,544 / 6,069

56.7 %3,467 / 6,113

56.9 %3,541 / 6,221

54.1 %3,337 / 6,173

55.0 %3,348 / 6,086

57.7 %3,518 / 6,096

57.2 %3,682 / 6,435

56.7 %3,107 / 5,484

56.5 %3,541 / 6,264

59.4 %3,425 / 5,769

71.2 %3,721 / 5,229

61.7 %3,511 / 5,690

58.1 %3,431 / 5,902

61.0 %3,471 / 5,690

69.5 %3,744 / 5,388

63.1 %3,632 / 5,759

57.7 %3,039 / 5,269

68.0 %3,501 / 5,146

59.3 %3,400 / 5,733

65.7 %3,588 / 5,465

58.7 %3,391 / 5,772

58.8 %3,412 / 5,805

65.7 %3,622 / 5,509

65.2 %3,629 / 5,570

65.3 %3,575 / 5,475

65.0 %3,631 / 5,588

59.3 %3,543 / 5,977

5.2 %226 / 4,340

60.1 %3,329 / 5,541

69.5 %3,766 / 5,416

67.6 %3,599 / 5,324

65.7 %3,564 / 5,427

50.9 %2,844 / 5,588

61.4 %3,509 / 5,713

68.2 %3,538 / 5,185

53.4 %3,003 / 5,625

57.5 %3,223 / 5,606

58.2 %3,441 / 5,908

65.6 %3,339 / 5,090

55.3 %2,913 / 5,267

54.1 %3,177 / 5,873

68.5 %3,691 / 5,386

65.4 %3,337 / 5,101

62.7 %3,488 / 5,563

63.6 %3,216 / 5,060

65.9 %3,321 / 5,036

55.4 %3,362 / 6,067

56.2 %3,391 / 6,039

54.7 %3,115 / 5,694

58.6 %3,381 / 5,769

58.9 %3,406 / 5,785

58.2 %3,455 / 5,939

59.4 %3,366 / 5,671

58.6 %3,322 / 5,673

59.1 %3,416 / 5,778

58.2 %3,384 / 5,811

58.1 %3,437 / 5,913

56.7 %3,301 / 5,824

58.5 %3,324 / 5,682

60.0 %3,446 / 5,748

56.3 %3,518 / 6,247

52.3 %2,894 / 5,536

52.8 %3,279 / 6,212

58.3 %3,260 / 5,590

67.9 %3,477 / 5,120

60.1 %3,320 / 5,528

55.5 %3,223 / 5,811

59.9 %3,302 / 5,517

66.0 %3,525 / 5,339

61.3 %3,457 / 5,640

53.5 %2,837 / 5,304

64.8 %3,268 / 5,044

58.2 %3,237 / 5,564

63.8 %3,394 / 5,321

57.0 %3,201 / 5,614

56.7 %3,208 / 5,653

64.2 %3,437 / 5,356

62.7 %3,436 / 5,476

63.0 %3,376 / 5,359

61.4 %3,391 / 5,525

56.0 %3,307 / 5,902

5.3 %232 / 4,393

58.8 %3,430 / 5,838

59.9 %3,392 / 5,661

58.0 %3,351 / 5,776

48.5 %2,857 / 5,890

58.6 %3,447 / 5,883

63.0 %3,426 / 5,438

51.2 %2,943 / 5,744

77.2 %3,823 / 4,952

71.9 %3,919 / 5,447

62.7 %3,282 / 5,237

52.7 %2,908 / 5,513

62.4 %3,499 / 5,606

59.2 %3,425 / 5,787

63.1 %3,290 / 5,214

65.2 %3,597 / 5,519

60.7 %3,158 / 5,205

63.4 %3,274 / 5,163

53.7 %3,329 / 6,202

54.3 %3,354 / 6,174

51.9 %3,048 / 5,868

55.2 %3,298 / 5,980

55.9 %3,340 / 5,973

55.4 %3,397 / 6,132

55.5 %3,264 / 5,884

54.5 %3,214 / 5,895

56.3 %3,353 / 5,957

55.1 %3,298 / 5,989

54.8 %3,356 / 6,120

53.3 %3,208 / 6,022

54.7 %3,219 / 5,885

56.2 %3,349 / 5,961

54.1 %3,467 / 6,414

50.9 %2,922 / 5,736

66.9 %3,786 / 5,656

64.2 %3,477 / 5,412

63.5 %3,365 / 5,296

69.5 %3,636 / 5,232

62.6 %3,508 / 5,603

63.9 %3,419 / 5,354

61.1 %3,392 / 5,552

62.1 %3,499 / 5,633

52.1 %2,866 / 5,505

63.4 %3,248 / 5,127

64.7 %3,466 / 5,361

61.9 %3,360 / 5,426

55.5 %3,178 / 5,730

55.5 %3,195 / 5,759

60.2 %3,327 / 5,526

65.5 %3,549 / 5,416

61.9 %3,347 / 5,406

58.2 %3,305 / 5,682

69.3 %3,767 / 5,435

5.3 %246 / 4,684

69.0 %3,777 / 5,471

70.4 %3,843 / 5,459

48.8 %2,978 / 6,105

60.7 %3,651 / 6,018

65.3 %3,625 / 5,548

52.4 %3,100 / 5,912

57.4 %3,359 / 5,850

57.6 %3,559 / 6,181

64.0 %3,461 / 5,407

52.5 %3,025 / 5,761

54.0 %3,309 / 6,129

68.3 %3,848 / 5,632

63.9 %3,449 / 5,401

61.1 %3,608 / 5,906

62.1 %3,334 / 5,369

64.1 %3,436 / 5,357

58.5 %3,575 / 6,107

59.2 %3,606 / 6,091

57.6 %3,321 / 5,767

61.6 %3,591 / 5,831

61.8 %3,613 / 5,845

61.8 %3,675 / 5,951

61.8 %3,562 / 5,762

61.0 %3,520 / 5,766

61.8 %3,614 / 5,852

60.9 %3,588 / 5,894

60.7 %3,646 / 6,010

59.7 %3,510 / 5,882

60.7 %3,512 / 5,784

62.9 %3,663 / 5,822

60.1 %3,755 / 6,246

49.7 %3,003 / 6,042

53.2 %3,427 / 6,438

60.3 %3,450 / 5,726

67.0 %3,605 / 5,380

60.0 %3,452 / 5,749

56.0 %3,361 / 5,997

58.8 %3,428 / 5,826

65.2 %3,647 / 5,592

60.5 %3,572 / 5,904

50.8 %2,937 / 5,787

62.7 %3,372 / 5,382

59.6 %3,411 / 5,720

63.3 %3,523 / 5,564

59.4 %3,396 / 5,717

58.5 %3,387 / 5,790

65.6 %3,637 / 5,547

61.9 %3,574 / 5,777

61.3 %3,467 / 5,653

60.3 %3,502 / 5,803

55.7 %3,441 / 6,183

6.9 %303 / 4,419

67.4 %3,656 / 5,423

53.9 %2,969 / 5,507

61.4 %3,553 / 5,787

66.1 %3,544 / 5,363

55.7 %3,127 / 5,611

57.8 %3,297 / 5,703

57.5 %3,472 / 6,039

63.1 %3,362 / 5,328

56.0 %2,985 / 5,328

54.0 %3,227 / 5,977

66.0 %3,676 / 5,567

64.7 %3,397 / 5,249

63.1 %3,563 / 5,644

61.4 %3,243 / 5,283

63.2 %3,340 / 5,282

61.3 %3,555 / 5,798

62.5 %3,583 / 5,736

60.6 %3,315 / 5,474

65.4 %3,602 / 5,508

65.5 %3,621 / 5,528

65.3 %3,685 / 5,639

65.6 %3,570 / 5,443

64.9 %3,528 / 5,438

65.7 %3,624 / 5,517

63.4 %3,557 / 5,610

62.9 %3,615 / 5,750

63.4 %3,518 / 5,547

63.9 %3,505 / 5,487

65.4 %3,626 / 5,542

63.4 %3,753 / 5,924

53.3 %2,974 / 5,580

54.2 %3,376 / 6,224

60.6 %3,369 / 5,560

66.0 %3,496 / 5,295

60.1 %3,376 / 5,615

58.4 %3,331 / 5,707

59.2 %3,342 / 5,649

66.6 %3,599 / 5,402

60.6 %3,489 / 5,759

54.6 %2,918 / 5,344

62.4 %3,291 / 5,271

60.2 %3,341 / 5,546

62.6 %3,424 / 5,468

62.0 %3,374 / 5,440

61.5 %3,380 / 5,497

67.3 %3,606 / 5,356

63.3 %3,515 / 5,556

61.4 %3,406 / 5,547

60.2 %3,415 / 5,672

56.8 %3,396 / 5,976

6.8 %305 / 4,482

50.8 %2,909 / 5,729

60.1 %3,541 / 5,896

64.7 %3,525 / 5,448

52.7 %3,047 / 5,787

55.5 %3,250 / 5,858

55.9 %3,428 / 6,130

62.1 %3,361 / 5,408

53.5 %2,946 / 5,502

51.6 %3,164 / 6,136

65.0 %3,679 / 5,656

62.5 %3,363 / 5,380

59.0 %3,474 / 5,887

60.0 %3,228 / 5,378

62.4 %3,341 / 5,356

57.4 %3,493 / 6,089

57.8 %3,514 / 6,084

55.9 %3,231 / 5,779

60.0 %3,497 / 5,824

60.4 %3,528 / 5,837

60.3 %3,592 / 5,958

60.2 %3,469 / 5,762

59.5 %3,427 / 5,761

60.0 %3,524 / 5,872

58.6 %3,475 / 5,928

57.9 %3,513 / 6,072

58.3 %3,425 / 5,870

59.1 %3,413 / 5,777

60.8 %3,549 / 5,838

58.6 %3,664 / 6,252

51.8 %2,954 / 5,701

52.1 %3,332 / 6,394

59.5 %3,370 / 5,665

65.1 %3,506 / 5,383

58.2 %3,337 / 5,735

54.2 %3,255 / 6,011

57.3 %3,328 / 5,807

64.3 %3,545 / 5,514

58.0 %3,427 / 5,905

52.2 %2,881 / 5,516

60.8 %3,266 / 5,376

59.1 %3,334 / 5,643

62.8 %3,444 / 5,481

58.2 %3,315 / 5,699

57.3 %3,300 / 5,762

63.2 %3,503 / 5,541

59.6 %3,443 / 5,776

58.8 %3,345 / 5,693

58.5 %3,396 / 5,804

54.3 %3,334 / 6,141

4.5 %168 / 3,700

56.0 %3,109 / 5,555

53.7 %2,939 / 5,474

54.5 %2,777 / 5,100

50.6 %2,899 / 5,724

50.4 %3,009 / 5,966

55.9 %2,923 / 5,231

60.4 %2,778 / 4,598

47.8 %2,785 / 5,823

54.1 %3,070 / 5,678

55.9 %2,946 / 5,267

53.8 %3,025 / 5,623

54.6 %2,827 / 5,176

55.9 %2,910 / 5,205

49.7 %2,968 / 5,971

50.0 %2,984 / 5,973

48.1 %2,717 / 5,651

50.0 %2,904 / 5,812

50.8 %2,946 / 5,800

51.1 %3,027 / 5,918

49.1 %2,833 / 5,775

48.2 %2,787 / 5,777

51.0 %2,954 / 5,793

47.3 %2,878 / 6,081

48.9 %2,951 / 6,039

47.3 %2,781 / 5,878

47.7 %2,784 / 5,831

51.1 %2,968 / 5,806

49.3 %3,066 / 6,218

60.7 %2,855 / 4,700

48.7 %2,972 / 6,098

51.2 %2,933 / 5,728

53.4 %2,983 / 5,589

53.5 %2,950 / 5,509

52.3 %2,936 / 5,609

52.9 %2,911 / 5,500

54.7 %3,001 / 5,491

52.9 %2,992 / 5,656

58.3 %2,733 / 4,684

56.3 %2,877 / 5,112

51.2 %2,911 / 5,691

54.3 %2,950 / 5,429

51.1 %2,826 / 5,527

51.3 %2,848 / 5,553

53.0 %2,967 / 5,596

54.9 %3,014 / 5,486

50.8 %2,917 / 5,747

52.4 %2,989 / 5,701

51.5 %2,972 / 5,770

6.6 %302 / 4,610

64.7 %3,584 / 5,536

57.4 %3,175 / 5,530

57.1 %3,391 / 5,934

56.4 %3,528 / 6,258

64.9 %3,504 / 5,401

58.1 %3,101 / 5,336

53.5 %3,293 / 6,154

64.0 %3,716 / 5,810

67.3 %3,587 / 5,330

63.5 %3,679 / 5,791

63.1 %3,381 / 5,355

65.1 %3,483 / 5,347

54.4 %3,480 / 6,393

54.5 %3,486 / 6,394

51.9 %3,176 / 6,118

55.2 %3,428 / 6,210

55.8 %3,466 / 6,207

56.0 %3,545 / 6,328

54.3 %3,351 / 6,170

53.6 %3,307 / 6,172

56.3 %3,485 / 6,195

53.8 %3,390 / 6,304

54.1 %3,460 / 6,390

52.2 %3,288 / 6,297

52.9 %3,291 / 6,219

55.9 %3,471 / 6,207

54.9 %3,621 / 6,590

58.5 %3,149 / 5,379

53.2 %3,445 / 6,481

57.0 %3,387 / 5,945

63.7 %3,557 / 5,582

58.7 %3,450 / 5,875

56.0 %3,396 / 6,062

59.6 %3,443 / 5,774

61.7 %3,564 / 5,778

60.0 %3,565 / 5,941

58.0 %3,053 / 5,267

64.4 %3,437 / 5,333

57.1 %3,364 / 5,890

64.0 %3,567 / 5,571

55.1 %3,288 / 5,968

55.0 %3,297 / 5,999

61.5 %3,528 / 5,739

63.5 %3,633 / 5,719

62.3 %3,534 / 5,672

61.3 %3,567 / 5,820

55.5 %3,451 / 6,219

5.2 %224 / 4,299

55.6 %3,053 / 5,491

60.7 %3,332 / 5,487

60.8 %3,522 / 5,793

70.0 %3,451 / 4,932

57.5 %2,967 / 5,161

57.2 %3,282 / 5,738

66.1 %3,610 / 5,462

69.7 %3,440 / 4,935

65.7 %3,580 / 5,450

67.7 %3,321 / 4,904

70.2 %3,425 / 4,882

57.2 %3,413 / 5,962

57.8 %3,438 / 5,943

54.8 %3,111 / 5,682

59.2 %3,395 / 5,733

59.6 %3,422 / 5,742

59.3 %3,487 / 5,880

60.0 %3,380 / 5,634

59.3 %3,336 / 5,628

59.5 %3,426 / 5,760

57.6 %3,365 / 5,843

57.5 %3,421 / 5,953

57.8 %3,326 / 5,752

58.7 %3,321 / 5,659

60.9 %3,469 / 5,700

58.0 %3,566 / 6,149

54.7 %2,959 / 5,414

56.8 %3,435 / 6,044

61.1 %3,345 / 5,478

67.0 %3,446 / 5,141

63.5 %3,423 / 5,390

59.2 %3,348 / 5,659

62.0 %3,354 / 5,407

65.4 %3,492 / 5,339

63.4 %3,514 / 5,542

55.7 %2,896 / 5,199

71.8 %3,444 / 4,796

61.0 %3,320 / 5,447

67.5 %3,491 / 5,170

58.6 %3,243 / 5,535

58.1 %3,243 / 5,584

64.3 %3,441 / 5,348

65.6 %3,523 / 5,371

65.4 %3,436 / 5,256

63.2 %3,449 / 5,458

59.2 %3,422 / 5,777

4.1 %159 / 3,895

51.0 %2,905 / 5,697

49.1 %3,015 / 6,146

57.2 %2,983 / 5,216

55.6 %2,767 / 4,979

46.4 %2,802 / 6,033

53.3 %3,114 / 5,840

57.0 %2,999 / 5,261

55.5 %3,114 / 5,615

56.4 %2,900 / 5,146

57.8 %2,976 / 5,146

49.2 %3,029 / 6,154

49.7 %3,043 / 6,119

46.8 %2,766 / 5,910

49.9 %3,011 / 6,037

50.0 %3,024 / 6,054

49.9 %3,090 / 6,195

50.3 %2,988 / 5,946

49.6 %2,941 / 5,924

49.9 %3,024 / 6,055

48.5 %2,962 / 6,110

48.5 %3,024 / 6,237

48.8 %2,939 / 6,027

49.5 %2,948 / 5,951

50.7 %3,047 / 6,011

49.2 %3,140 / 6,376

57.9 %2,844 / 4,909

47.8 %2,960 / 6,193

50.6 %2,929 / 5,785

54.9 %3,009 / 5,476

51.1 %2,932 / 5,734

49.4 %2,931 / 5,930

52.2 %2,942 / 5,631

54.7 %3,084 / 5,635

52.2 %3,039 / 5,824

54.9 %2,728 / 4,972

56.6 %2,914 / 5,146

52.0 %2,922 / 5,621

54.3 %3,005 / 5,531

51.0 %2,884 / 5,653

51.2 %2,901 / 5,667

54.9 %3,013 / 5,486

55.8 %3,076 / 5,516

53.6 %2,977 / 5,551

54.4 %3,046 / 5,604

50.7 %2,979 / 5,873

4.4 %192 / 4,335

73.5 %3,943 / 5,363

67.2 %3,401 / 5,059

56.1 %3,002 / 5,355

65.9 %3,594 / 5,452

62.4 %3,520 / 5,645

67.4 %3,404 / 5,052

65.3 %3,568 / 5,466

65.4 %3,277 / 5,013

67.9 %3,389 / 4,991

56.3 %3,413 / 6,059

57.1 %3,440 / 6,028

51.6 %3,026 / 5,863

54.2 %3,250 / 5,994

54.9 %3,290 / 5,990

55.0 %3,372 / 6,130

53.7 %3,183 / 5,924

52.7 %3,133 / 5,942

55.5 %3,312 / 5,971

53.6 %3,230 / 6,028

53.4 %3,296 / 6,176

51.7 %3,130 / 6,058

52.7 %3,130 / 5,939

54.7 %3,286 / 6,002

54.0 %3,449 / 6,387

54.2 %3,009 / 5,551

70.6 %3,875 / 5,491

67.0 %3,527 / 5,268

67.1 %3,461 / 5,160

74.8 %3,771 / 5,039

67.2 %3,634 / 5,404

68.0 %3,518 / 5,175

65.6 %3,519 / 5,363

64.0 %3,533 / 5,523

55.8 %2,964 / 5,315

68.5 %3,375 / 4,930

67.7 %3,521 / 5,200

64.8 %3,438 / 5,302

58.2 %3,254 / 5,593

58.1 %3,272 / 5,631

62.9 %3,397 / 5,404

67.2 %3,567 / 5,309

64.8 %3,418 / 5,276

60.7 %3,370 / 5,552

74.3 %3,886 / 5,228

4.8 %236 / 4,894

62.2 %3,456 / 5,558

53.3 %3,056 / 5,731

70.5 %3,940 / 5,592

60.9 %3,665 / 6,020

62.0 %3,444 / 5,557

63.4 %3,730 / 5,880

59.9 %3,319 / 5,540

62.7 %3,442 / 5,491

56.0 %3,569 / 6,377

56.4 %3,591 / 6,362

50.8 %3,159 / 6,220

54.2 %3,416 / 6,300

54.7 %3,448 / 6,304

55.1 %3,534 / 6,412

53.2 %3,336 / 6,265

52.3 %3,284 / 6,281

54.8 %3,451 / 6,302

52.9 %3,373 / 6,380

53.0 %3,445 / 6,502

51.2 %3,279 / 6,401

52.4 %3,289 / 6,280

55.4 %3,484 / 6,289

53.9 %3,612 / 6,698

52.2 %3,070 / 5,882

73.2 %4,184 / 5,719

65.2 %3,686 / 5,652

61.9 %3,502 / 5,654

76.4 %4,034 / 5,278

64.7 %3,742 / 5,786

63.9 %3,613 / 5,653

62.7 %3,619 / 5,771

63.8 %3,747 / 5,872

53.6 %3,017 / 5,626

61.8 %3,392 / 5,485

64.3 %3,635 / 5,654

61.8 %3,531 / 5,717

55.6 %3,347 / 6,016

55.2 %3,353 / 6,069

60.1 %3,509 / 5,834

63.4 %3,674 / 5,796

61.4 %3,520 / 5,737

57.3 %3,457 / 6,034

73.2 %4,101 / 5,603

4.3 %170 / 3,965

66.0 %3,098 / 4,692

60.2 %3,262 / 5,419

72.6 %3,680 / 5,068

83.3 %3,629 / 4,359

68.7 %3,526 / 5,136

93.1 %3,742 / 4,020

95.9 %3,848 / 4,011

63.0 %3,544 / 5,628

63.3 %3,559 / 5,622

55.9 %3,079 / 5,512

58.6 %3,314 / 5,660

59.4 %3,355 / 5,648

59.6 %3,440 / 5,774

58.0 %3,250 / 5,604

57.1 %3,196 / 5,593

59.9 %3,378 / 5,636

57.7 %3,288 / 5,695

57.5 %3,358 / 5,841

56.1 %3,199 / 5,706

56.6 %3,188 / 5,635

59.5 %3,359 / 5,644

58.8 %3,531 / 6,005

62.9 %3,086 / 4,905

59.2 %3,409 / 5,755

66.1 %3,376 / 5,111

78.2 %3,604 / 4,606

69.1 %3,474 / 5,030

63.8 %3,375 / 5,293

68.9 %3,455 / 5,017

74.0 %3,618 / 4,889

70.0 %3,588 / 5,128

66.3 %3,048 / 4,598

82.5 %3,562 / 4,316

65.3 %3,333 / 5,105

76.7 %3,631 / 4,733

63.9 %3,330 / 5,208

63.8 %3,344 / 5,241

71.6 %3,512 / 4,905

70.8 %3,524 / 4,979

77.1 %3,623 / 4,702

71.3 %3,541 / 4,966

64.4 %3,459 / 5,373

4.6 %160 / 3,502

52.8 %2,902 / 5,498

59.8 %3,180 / 5,316

65.1 %3,088 / 4,741

59.0 %3,122 / 5,292

64.4 %2,991 / 4,646

66.3 %3,079 / 4,646

55.5 %3,132 / 5,647

55.6 %3,143 / 5,652

51.3 %2,775 / 5,411

52.8 %2,958 / 5,597

53.7 %2,999 / 5,589

53.7 %3,076 / 5,730

52.3 %2,896 / 5,535

51.3 %2,846 / 5,544

54.1 %3,016 / 5,575

51.0 %2,931 / 5,746

51.8 %2,999 / 5,793

50.2 %2,839 / 5,651

50.9 %2,843 / 5,585

53.8 %3,008 / 5,590

52.8 %3,151 / 5,969

80.1 %3,212 / 4,012

52.0 %3,013 / 5,789

56.0 %3,001 / 5,358

62.2 %3,126 / 5,022

58.0 %3,044 / 5,244

55.3 %2,991 / 5,408

61.5 %3,060 / 4,974

61.1 %3,143 / 5,141

60.0 %3,144 / 5,238

81.0 %3,155 / 3,897

66.3 %3,033 / 4,576

56.6 %2,999 / 5,300

62.0 %3,097 / 4,993

58.0 %2,987 / 5,153

57.9 %2,994 / 5,174

60.7 %3,095 / 5,103

60.8 %3,122 / 5,138

59.8 %3,068 / 5,129

59.6 %3,129 / 5,250

55.0 %3,021 / 5,496

5.3 %240 / 4,559

56.7 %3,396 / 5,993

60.0 %3,261 / 5,439

61.1 %3,511 / 5,746

57.7 %3,126 / 5,414

60.4 %3,245 / 5,369

53.5 %3,353 / 6,271

53.6 %3,358 / 6,270

49.0 %2,973 / 6,072

51.1 %3,178 / 6,217

51.5 %3,205 / 6,219

52.0 %3,291 / 6,333

50.3 %3,111 / 6,180

49.6 %3,064 / 6,177

52.0 %3,225 / 6,203

50.1 %3,149 / 6,290

50.0 %3,213 / 6,432

48.2 %3,046 / 6,320

49.5 %3,065 / 6,190

51.8 %3,229 / 6,231

50.4 %3,346 / 6,637

51.0 %2,892 / 5,674

62.5 %3,703 / 5,923

62.0 %3,468 / 5,591

58.6 %3,274 / 5,583

74.6 %3,841 / 5,146

62.4 %3,537 / 5,668

62.2 %3,428 / 5,510

59.1 %3,386 / 5,726

59.8 %3,483 / 5,820

52.4 %2,844 / 5,427

62.0 %3,268 / 5,273

63.6 %3,498 / 5,497

61.4 %3,402 / 5,537

54.9 %3,195 / 5,815

54.5 %3,199 / 5,871

60.2 %3,390 / 5,631

60.6 %3,442 / 5,677

60.4 %3,368 / 5,579

54.9 %3,254 / 5,925

62.7 %3,630 / 5,794

5.2 %241 / 4,663

72.2 %3,662 / 5,073

64.6 %3,694 / 5,717

70.0 %3,535 / 5,050

72.3 %3,642 / 5,038

61.9 %3,714 / 6,001

62.2 %3,731 / 5,997

55.8 %3,276 / 5,870

59.3 %3,531 / 5,954

59.9 %3,568 / 5,956

60.4 %3,657 / 6,058

58.6 %3,462 / 5,904

57.5 %3,407 / 5,921

60.3 %3,583 / 5,945

59.6 %3,552 / 5,958

60.0 %3,628 / 6,044

57.1 %3,431 / 6,008

57.3 %3,401 / 5,935

60.2 %3,587 / 5,955

60.2 %3,781 / 6,283

58.4 %3,190 / 5,460

56.5 %3,553 / 6,284

62.0 %3,511 / 5,662

75.8 %3,821 / 5,041

62.9 %3,545 / 5,639

59.7 %3,493 / 5,854

63.2 %3,547 / 5,611

72.2 %3,839 / 5,319

65.4 %3,714 / 5,677

59.4 %3,115 / 5,245

69.8 %3,555 / 5,091

61.4 %3,471 / 5,651

68.8 %3,692 / 5,367

62.2 %3,495 / 5,622

61.4 %3,489 / 5,680

69.3 %3,731 / 5,387

65.0 %3,656 / 5,622

68.2 %3,659 / 5,364

66.2 %3,673 / 5,549

60.0 %3,582 / 5,973

3.9 %156 / 3,977

69.9 %3,575 / 5,111

80.9 %3,497 / 4,322

83.9 %3,608 / 4,300

63.4 %3,534 / 5,572

63.8 %3,555 / 5,571

57.7 %3,114 / 5,400

60.4 %3,345 / 5,539

61.1 %3,382 / 5,536

61.5 %3,474 / 5,651

60.1 %3,282 / 5,463

58.8 %3,227 / 5,486

61.9 %3,406 / 5,505

59.5 %3,324 / 5,589

59.1 %3,386 / 5,731

57.0 %3,203 / 5,623

58.7 %3,222 / 5,490

61.4 %3,385 / 5,513

59.7 %3,541 / 5,933

61.3 %3,088 / 5,037

60.4 %3,447 / 5,704

67.4 %3,408 / 5,054

79.3 %3,618 / 4,560

69.7 %3,476 / 4,988

64.7 %3,398 / 5,252

68.9 %3,469 / 5,034

74.7 %3,622 / 4,851

69.8 %3,582 / 5,129

63.7 %3,038 / 4,768

81.7 %3,538 / 4,330

66.8 %3,370 / 5,043

76.4 %3,622 / 4,739

64.6 %3,337 / 5,169

64.4 %3,356 / 5,212

73.7 %3,568 / 4,838

72.2 %3,574 / 4,950

74.8 %3,556 / 4,752

73.1 %3,598 / 4,919

63.4 %3,434 / 5,415

4.5 %207 / 4,602

66.0 %3,383 / 5,128

69.0 %3,510 / 5,084

59.6 %3,628 / 6,091

60.5 %3,654 / 6,037

57.4 %3,337 / 5,815

60.7 %3,596 / 5,920

61.8 %3,642 / 5,897

62.0 %3,724 / 6,008

59.9 %3,528 / 5,885

58.8 %3,461 / 5,885

62.0 %3,654 / 5,896

59.9 %3,574 / 5,962

59.7 %3,642 / 6,096

57.2 %3,436 / 6,012

58.7 %3,466 / 5,906

62.1 %3,652 / 5,877

60.9 %3,802 / 6,248

57.2 %3,110 / 5,439

60.6 %3,662 / 6,039

63.9 %3,558 / 5,564

67.4 %3,583 / 5,314

66.3 %3,627 / 5,473

62.0 %3,540 / 5,714

69.8 %3,695 / 5,291

65.2 %3,605 / 5,527

68.2 %3,794 / 5,562

58.4 %3,048 / 5,216

69.3 %3,496 / 5,045

64.0 %3,537 / 5,525

64.2 %3,521 / 5,482

61.1 %3,443 / 5,636

61.1 %3,466 / 5,669

65.3 %3,582 / 5,487

96.9 %4,465 / 4,610

65.4 %3,548 / 5,425

63.2 %3,548 / 5,612

63.2 %3,650 / 5,771

6.4 %242 / 3,797

92.2 %3,690 / 4,004

60.7 %3,396 / 5,599

61.1 %3,415 / 5,593

54.1 %2,956 / 5,463

56.7 %3,184 / 5,613

57.5 %3,222 / 5,606

57.7 %3,306 / 5,733

56.3 %3,123 / 5,544

55.2 %3,068 / 5,558

58.1 %3,245 / 5,587

56.0 %3,158 / 5,644

55.7 %3,229 / 5,795

54.3 %3,074 / 5,661

55.0 %3,065 / 5,572

57.6 %3,227 / 5,600

56.9 %3,394 / 5,965

61.6 %2,984 / 4,846

57.5 %3,289 / 5,720

64.2 %3,254 / 5,069

75.9 %3,467 / 4,565

66.6 %3,335 / 5,006

61.9 %3,257 / 5,258

66.3 %3,317 / 5,006

71.7 %3,479 / 4,855

67.2 %3,435 / 5,109

65.0 %2,947 / 4,536

79.5 %3,415 / 4,295

63.4 %3,210 / 5,062

73.6 %3,479 / 4,730

61.4 %3,194 / 5,200

61.4 %3,211 / 5,228

69.3 %3,381 / 4,879

68.0 %3,381 / 4,973

74.1 %3,469 / 4,681

69.3 %3,418 / 4,934

62.1 %3,325 / 5,353

4.3 %166 / 3,894

62.4 %3,499 / 5,604

62.9 %3,520 / 5,594

56.1 %3,063 / 5,458

58.8 %3,297 / 5,608

59.6 %3,338 / 5,596

59.8 %3,422 / 5,726

58.2 %3,232 / 5,554

57.4 %3,179 / 5,540

60.2 %3,360 / 5,585

58.0 %3,271 / 5,639

57.8 %3,342 / 5,786

56.2 %3,179 / 5,656

56.9 %3,173 / 5,572

59.8 %3,342 / 5,587

58.8 %3,504 / 5,963

62.9 %3,065 / 4,872

59.7 %3,398 / 5,692

67.1 %3,374 / 5,029

78.9 %3,582 / 4,541

69.6 %3,457 / 4,965

64.2 %3,362 / 5,235

69.0 %3,434 / 4,980

74.0 %3,586 / 4,845

69.9 %3,559 / 5,092

66.3 %3,027 / 4,563

82.9 %3,536 / 4,266

65.9 %3,320 / 5,038

76.7 %3,598 / 4,693

63.9 %3,302 / 5,167

63.8 %3,317 / 5,200

71.7 %3,485 / 4,860

71.2 %3,508 / 4,926

77.0 %3,586 / 4,655

71.6 %3,521 / 4,916

64.7 %3,443 / 5,321

6.5 %314 / 4,795

87.0 %4,480 / 5,147

70.6 %3,774 / 5,345

74.6 %4,032 / 5,406

75.3 %4,067 / 5,401

76.1 %4,163 / 5,474

73.3 %3,954 / 5,396

72.2 %3,895 / 5,398

75.2 %4,069 / 5,408

72.1 %3,981 / 5,524

72.1 %4,059 / 5,632

74.1 %4,000 / 5,396

71.1 %3,878 / 5,458

72.9 %4,020 / 5,512

81.0 %4,466 / 5,512

54.7 %3,154 / 5,763

52.4 %3,465 / 6,612

61.6 %3,541 / 5,753

63.2 %3,583 / 5,665

58.9 %3,491 / 5,926

58.7 %3,491 / 5,949

59.2 %3,513 / 5,933

63.6 %3,659 / 5,750

62.3 %3,710 / 5,954

55.8 %3,092 / 5,539

60.5 %3,409 / 5,639

60.0 %3,481 / 5,798

60.9 %3,545 / 5,821

84.2 %4,183 / 4,965

80.0 %4,093 / 5,119

65.3 %3,708 / 5,677

60.5 %3,605 / 5,956

59.2 %3,492 / 5,894

57.3 %3,471 / 6,059

54.2 %3,465 / 6,390

7.8 %372 / 4,765

71.4 %3,788 / 5,302

75.0 %4,037 / 5,383

76.1 %4,083 / 5,363

76.7 %4,173 / 5,444

74.0 %3,966 / 5,358

73.1 %3,912 / 5,353

76.1 %4,083 / 5,364

72.9 %3,996 / 5,484

72.6 %4,067 / 5,600

73.1 %3,955 / 5,410

71.7 %3,888 / 5,422

73.9 %4,039 / 5,462

80.4 %4,429 / 5,511

54.3 %3,169 / 5,836

53.1 %3,489 / 6,573

61.4 %3,548 / 5,775

63.8 %3,610 / 5,662

59.2 %3,508 / 5,924

58.8 %3,507 / 5,960

59.7 %3,540 / 5,925

64.0 %3,681 / 5,756

62.9 %3,740 / 5,945

55.0 %3,102 / 5,640

61.2 %3,432 / 5,609

60.5 %3,501 / 5,789

61.5 %3,564 / 5,795

83.7 %4,146 / 4,953

81.0 %4,106 / 5,071

66.3 %3,729 / 5,627

61.6 %3,635 / 5,900

59.7 %3,512 / 5,882

57.8 %3,498 / 6,053

54.9 %3,490 / 6,358

6.5 %275 / 4,255

85.8 %4,083 / 4,758

87.9 %4,148 / 4,719

87.3 %4,210 / 4,821

84.3 %4,000 / 4,745

83.2 %3,951 / 4,746

87.2 %4,129 / 4,735

83.0 %4,039 / 4,866

82.1 %4,091 / 4,983

76.5 %3,812 / 4,986

80.1 %3,883 / 4,849

80.9 %3,994 / 4,935

76.9 %4,082 / 5,311

48.8 %2,769 / 5,670

48.9 %3,123 / 6,387

55.2 %3,117 / 5,651

57.8 %3,168 / 5,483

54.4 %3,115 / 5,722

53.0 %3,084 / 5,821

54.1 %3,109 / 5,744

57.2 %3,219 / 5,627

56.4 %3,282 / 5,818

49.4 %2,697 / 5,463

56.7 %3,055 / 5,387

54.9 %3,093 / 5,638

54.9 %3,108 / 5,657

69.8 %3,524 / 5,052

70.1 %3,564 / 5,086

60.2 %3,304 / 5,491

58.3 %3,313 / 5,682

54.1 %3,087 / 5,708

52.8 %3,098 / 5,864

50.5 %3,112 / 6,159

6.5 %297 / 4,585

92.4 %4,420 / 4,782

93.1 %4,510 / 4,846

90.9 %4,321 / 4,752

89.3 %4,258 / 4,766

91.4 %4,391 / 4,802

86.7 %4,286 / 4,946

86.2 %4,354 / 5,052

82.5 %4,123 / 4,999

87.2 %4,217 / 4,835

86.4 %4,284 / 4,956

82.3 %4,384 / 5,324

50.5 %2,949 / 5,843

52.0 %3,369 / 6,481

58.1 %3,351 / 5,768

60.8 %3,408 / 5,604

57.4 %3,344 / 5,830

55.9 %3,316 / 5,935

57.0 %3,342 / 5,868

60.7 %3,469 / 5,718

59.2 %3,512 / 5,930

50.9 %2,875 / 5,643

58.0 %3,242 / 5,586

57.5 %3,317 / 5,768

58.0 %3,347 / 5,771

73.7 %3,780 / 5,130

73.6 %3,809 / 5,175

62.8 %3,533 / 5,624

61.7 %3,572 / 5,787

56.6 %3,311 / 5,848

55.9 %3,339 / 5,968

53.2 %3,345 / 6,285

6.5 %299 / 4,615

93.8 %4,543 / 4,844

90.6 %4,329 / 4,776

89.6 %4,280 / 4,777

92.6 %4,436 / 4,791

87.8 %4,330 / 4,934

87.4 %4,401 / 5,037

82.8 %4,146 / 5,009

86.4 %4,213 / 4,877

87.4 %4,324 / 4,949

83.2 %4,427 / 5,320

51.2 %2,989 / 5,836

52.5 %3,402 / 6,480

59.1 %3,394 / 5,744

61.6 %3,449 / 5,602

58.0 %3,382 / 5,829

56.6 %3,354 / 5,923

57.6 %3,378 / 5,868

61.4 %3,510 / 5,718

60.0 %3,556 / 5,925

51.8 %2,916 / 5,632

58.8 %3,280 / 5,578

58.4 %3,356 / 5,750

58.7 %3,387 / 5,767

74.4 %3,815 / 5,127

74.7 %3,853 / 5,159

63.6 %3,573 / 5,615

62.8 %3,618 / 5,764

57.2 %3,345 / 5,850

56.7 %3,382 / 5,960

53.9 %3,383 / 6,279

6.9 %329 / 4,769

90.2 %4,398 / 4,874

89.1 %4,343 / 4,876

93.4 %4,532 / 4,853

88.5 %4,432 / 5,009

88.3 %4,506 / 5,102

82.4 %4,209 / 5,105

86.2 %4,286 / 4,972

87.8 %4,414 / 5,029

84.4 %4,532 / 5,370

51.4 %3,067 / 5,966

52.8 %3,484 / 6,602

59.4 %3,476 / 5,850

61.7 %3,532 / 5,721

58.4 %3,467 / 5,936

57.0 %3,439 / 6,035

57.8 %3,462 / 5,991

61.8 %3,593 / 5,814

60.5 %3,642 / 6,024

51.8 %2,991 / 5,774

59.0 %3,365 / 5,707

58.6 %3,439 / 5,864

58.9 %3,470 / 5,892

74.7 %3,901 / 5,221

75.7 %3,963 / 5,232

64.0 %3,661 / 5,718

62.9 %3,699 / 5,877

57.4 %3,428 / 5,971

56.9 %3,464 / 6,093

54.1 %3,467 / 6,408

6.6 %296 / 4,483

92.3 %4,283 / 4,642

91.7 %4,353 / 4,745

87.1 %4,254 / 4,883

86.4 %4,318 / 5,000

84.2 %4,126 / 4,901

88.9 %4,216 / 4,742

86.6 %4,246 / 4,901

80.3 %4,290 / 5,341

49.8 %2,883 / 5,784

51.3 %3,294 / 6,424

57.4 %3,282 / 5,722

60.2 %3,340 / 5,544

56.7 %3,276 / 5,782

54.9 %3,242 / 5,901

56.4 %3,275 / 5,807

59.9 %3,400 / 5,674

58.5 %3,444 / 5,890

50.3 %2,810 / 5,581

57.6 %3,184 / 5,523

56.8 %3,247 / 5,715

57.5 %3,283 / 5,714

73.3 %3,727 / 5,084

73.3 %3,757 / 5,127

62.2 %3,468 / 5,578

61.1 %3,509 / 5,747

56.1 %3,247 / 5,789

55.4 %3,272 / 5,910

52.7 %3,279 / 6,221

6.5 %289 / 4,438

90.3 %4,293 / 4,754

86.1 %4,206 / 4,883

85.0 %4,257 / 5,007

83.4 %4,084 / 4,894

87.5 %4,158 / 4,753

84.8 %4,176 / 4,925

79.1 %4,230 / 5,350

48.9 %2,833 / 5,788

50.2 %3,240 / 6,455

56.4 %3,232 / 5,730

59.0 %3,286 / 5,566

55.5 %3,220 / 5,801

53.9 %3,187 / 5,912

55.3 %3,224 / 5,825

58.8 %3,346 / 5,686

57.3 %3,383 / 5,907

49.6 %2,766 / 5,578

56.6 %3,129 / 5,524

55.9 %3,199 / 5,721

56.4 %3,231 / 5,727

72.3 %3,674 / 5,081

72.2 %3,702 / 5,124

61.4 %3,420 / 5,569

59.9 %3,441 / 5,748

55.0 %3,191 / 5,798

54.3 %3,218 / 5,922

51.7 %3,226 / 6,237

6.5 %300 / 4,609

88.9 %4,360 / 4,903

88.8 %4,441 / 5,001

82.8 %4,146 / 5,007

86.8 %4,221 / 4,862

87.6 %4,336 / 4,951

82.7 %4,413 / 5,333

51.6 %3,004 / 5,824

52.9 %3,420 / 6,467

59.4 %3,403 / 5,731

62.3 %3,472 / 5,575

58.5 %3,402 / 5,811

56.9 %3,367 / 5,918

58.1 %3,402 / 5,852

61.4 %3,511 / 5,718

60.5 %3,573 / 5,910

52.2 %2,931 / 5,618

59.4 %3,305 / 5,564

58.8 %3,370 / 5,732

58.8 %3,393 / 5,769

74.7 %3,824 / 5,118

75.1 %3,864 / 5,147

64.2 %3,586 / 5,587

63.1 %3,635 / 5,758

57.7 %3,367 / 5,834

57.1 %3,396 / 5,948

54.4 %3,403 / 6,261

6.6 %304 / 4,640

90.6 %4,482 / 4,947

80.7 %4,103 / 5,084

84.7 %4,182 / 4,938

83.4 %4,237 / 5,083

79.0 %4,320 / 5,466

48.8 %2,927 / 5,994

51.1 %3,340 / 6,537

56.9 %3,320 / 5,838

59.8 %3,382 / 5,656

56.1 %3,315 / 5,904

54.4 %3,282 / 6,038

56.0 %3,322 / 5,937

58.7 %3,423 / 5,834

58.2 %3,492 / 5,998

49.5 %2,860 / 5,774

57.3 %3,219 / 5,621

56.3 %3,286 / 5,832

56.6 %3,310 / 5,844

71.4 %3,736 / 5,233

72.6 %3,800 / 5,231

61.4 %3,497 / 5,698

60.9 %3,552 / 5,828

55.8 %3,286 / 5,893

55.1 %3,315 / 6,017

52.7 %3,329 / 6,321

8.1 %389 / 4,774

79.3 %4,143 / 5,222

82.6 %4,205 / 5,092

83.3 %4,315 / 5,181

78.8 %4,386 / 5,567

49.7 %2,992 / 6,023

51.2 %3,415 / 6,674

56.4 %3,385 / 6,004

59.4 %3,450 / 5,808

55.7 %3,379 / 6,061

54.7 %3,364 / 6,152

55.8 %3,390 / 6,077

58.6 %3,493 / 5,958

58.4 %3,570 / 6,108

50.1 %2,922 / 5,832

57.1 %3,288 / 5,763

55.9 %3,350 / 5,994

56.2 %3,371 / 5,996

71.0 %3,804 / 5,355

72.5 %3,876 / 5,343

61.0 %3,561 / 5,842

60.5 %3,616 / 5,981

55.5 %3,351 / 6,036

54.8 %3,380 / 6,171

52.7 %3,402 / 6,461

7.1 %319 / 4,516

84.8 %4,128 / 4,867

80.4 %4,112 / 5,115

84.0 %4,405 / 5,246

48.3 %2,838 / 5,881

49.2 %3,232 / 6,565

54.8 %3,216 / 5,873

57.5 %3,272 / 5,695

53.5 %3,188 / 5,963

53.2 %3,188 / 5,988

54.4 %3,225 / 5,932

57.2 %3,333 / 5,824

56.1 %3,383 / 6,028

48.6 %2,762 / 5,683

55.0 %3,114 / 5,660

54.3 %3,187 / 5,864

55.1 %3,226 / 5,850

73.5 %3,759 / 5,115

70.4 %3,694 / 5,244

59.2 %3,379 / 5,708

58.1 %3,416 / 5,875

53.8 %3,188 / 5,921

53.1 %3,211 / 6,045

50.9 %3,230 / 6,348

6.4 %286 / 4,461

83.6 %4,156 / 4,971

79.4 %4,249 / 5,349

48.5 %2,829 / 5,829

50.3 %3,247 / 6,451

55.9 %3,221 / 5,759

58.8 %3,276 / 5,569

55.2 %3,213 / 5,816

53.7 %3,188 / 5,932

55.3 %3,223 / 5,828

58.4 %3,335 / 5,707

57.2 %3,383 / 5,918

49.0 %2,758 / 5,625

56.2 %3,121 / 5,550

55.5 %3,190 / 5,746

56.2 %3,225 / 5,743

71.5 %3,664 / 5,124

72.5 %3,717 / 5,126

60.8 %3,403 / 5,599

59.7 %3,446 / 5,768

54.6 %3,182 / 5,824

54.3 %3,216 / 5,926

51.9 %3,231 / 6,231

6.8 %317 / 4,648

79.7 %4,358 / 5,467

51.5 %2,993 / 5,815

52.5 %3,408 / 6,495

59.3 %3,413 / 5,760

61.2 %3,443 / 5,628

58.1 %3,398 / 5,844

56.0 %3,340 / 5,963

57.9 %3,394 / 5,866

61.5 %3,523 / 5,724

60.1 %3,574 / 5,944

51.8 %2,917 / 5,634

58.9 %3,284 / 5,574

58.6 %3,376 / 5,758

60.1 %3,431 / 5,707

72.3 %3,777 / 5,221

72.2 %3,799 / 5,260

63.6 %3,573 / 5,615

63.2 %3,629 / 5,743

57.3 %3,352 / 5,850

57.2 %3,399 / 5,942

53.8 %3,387 / 6,290

7.1 %360 / 5,105

51.6 %3,150 / 6,107

51.7 %3,553 / 6,874

56.9 %3,518 / 6,184

60.1 %3,607 / 6,001

56.0 %3,510 / 6,268

56.2 %3,511 / 6,247

57.0 %3,552 / 6,236

60.2 %3,670 / 6,100

59.2 %3,730 / 6,299

51.6 %3,058 / 5,925

57.5 %3,429 / 5,968

56.5 %3,490 / 6,176

57.9 %3,562 / 6,151

78.8 %4,169 / 5,288

75.9 %4,112 / 5,417

62.4 %3,729 / 5,980

61.7 %3,775 / 6,118

56.6 %3,520 / 6,218

55.8 %3,542 / 6,350

53.1 %3,543 / 6,670

5.1 %188 / 3,667

51.1 %3,044 / 5,957

54.1 %3,022 / 5,587

58.1 %3,107 / 5,347

56.1 %3,027 / 5,398

54.6 %3,014 / 5,522

59.4 %3,045 / 5,125

59.5 %3,137 / 5,270

58.9 %3,158 / 5,363

84.3 %3,284 / 3,896

62.0 %3,017 / 4,864

54.5 %3,006 / 5,516

58.8 %3,075 / 5,231

54.9 %2,969 / 5,412

54.9 %2,979 / 5,422

57.2 %3,076 / 5,378

58.6 %3,101 / 5,296

56.2 %3,061 / 5,445

56.7 %3,096 / 5,457

54.6 %3,041 / 5,572

5.3 %261 / 4,953

60.7 %3,579 / 5,892

58.6 %3,444 / 5,876

70.3 %3,877 / 5,516

63.7 %3,738 / 5,870

61.6 %3,562 / 5,785

59.1 %3,537 / 5,983

59.3 %3,614 / 6,093

51.9 %2,984 / 5,755

60.2 %3,384 / 5,624

60.9 %3,560 / 5,846

58.9 %3,472 / 5,897

53.0 %3,281 / 6,191

53.0 %3,301 / 6,231

55.9 %3,399 / 6,081

62.1 %3,660 / 5,892

57.2 %3,417 / 5,972

54.8 %3,399 / 6,199

84.8 %4,469 / 5,272

5.0 %218 / 4,327

66.4 %3,437 / 5,176

69.3 %3,613 / 5,210

65.0 %3,548 / 5,458

64.3 %3,449 / 5,364

64.2 %3,476 / 5,418

62.9 %3,521 / 5,599

55.8 %2,981 / 5,342

66.3 %3,324 / 5,013

90.5 %4,101 / 4,529

64.4 %3,440 / 5,345

61.3 %3,320 / 5,415

60.9 %3,330 / 5,467

66.8 %3,514 / 5,264

64.5 %3,512 / 5,446

63.7 %3,397 / 5,331

59.9 %3,350 / 5,593

63.4 %3,574 / 5,635

4.0 %165 / 4,143

68.8 %3,521 / 5,119

64.0 %3,453 / 5,399

68.2 %3,516 / 5,157

79.5 %3,829 / 4,816

71.2 %3,690 / 5,180

60.6 %3,062 / 5,055

76.9 %3,505 / 4,558

66.0 %3,404 / 5,157

73.2 %3,615 / 4,941

64.6 %3,387 / 5,240

64.3 %3,402 / 5,288

74.7 %3,658 / 4,895

69.6 %3,583 / 5,148

72.8 %3,563 / 4,893

71.3 %3,605 / 5,058

62.4 %3,471 / 5,559

5.1 %221 / 4,371

73.9 %3,806 / 5,150

70.1 %3,607 / 5,145

69.3 %3,629 / 5,233

68.9 %3,702 / 5,371

58.1 %2,988 / 5,139

69.7 %3,435 / 4,926

68.9 %3,580 / 5,195

67.5 %3,517 / 5,207

59.9 %3,308 / 5,518

59.9 %3,325 / 5,554

65.2 %3,477 / 5,336

68.1 %3,626 / 5,321

66.0 %3,478 / 5,267

62.5 %3,447 / 5,517

71.4 %3,828 / 5,360

6.0 %268 / 4,451

64.9 %3,515 / 5,412

65.7 %3,574 / 5,444

63.9 %3,601 / 5,632

56.5 %2,973 / 5,261

64.7 %3,352 / 5,182

64.7 %3,521 / 5,438

62.0 %3,427 / 5,525

58.5 %3,289 / 5,625

58.0 %3,298 / 5,687

61.8 %3,434 / 5,555

63.6 %3,538 / 5,561

61.2 %3,394 / 5,549

57.6 %3,350 / 5,811

64.8 %3,686 / 5,687

5.6 %236 / 4,244

67.7 %3,578 / 5,285

68.9 %3,677 / 5,337

61.0 %2,994 / 4,905

69.7 %3,424 / 4,912

64.7 %3,433 / 5,308

67.6 %3,519 / 5,205

61.0 %3,341 / 5,479

60.7 %3,356 / 5,526

64.6 %3,484 / 5,390

71.7 %3,693 / 5,152

66.8 %3,500 / 5,241

62.4 %3,415 / 5,472

64.1 %3,552 / 5,544

5.3 %230 / 4,376

69.9 %3,734 / 5,345

60.9 %3,077 / 5,051

71.3 %3,490 / 4,896

63.5 %3,435 / 5,412

71.5 %3,666 / 5,130

64.0 %3,448 / 5,389

64.0 %3,467 / 5,420

71.0 %3,683 / 5,190

67.1 %3,604 / 5,370

69.9 %3,617 / 5,178

66.5 %3,589 / 5,395

62.6 %3,555 / 5,675

5.0 %233 / 4,632

59.7 %3,081 / 5,164

68.1 %3,491 / 5,124

62.6 %3,490 / 5,571

66.8 %3,602 / 5,393

63.0 %3,508 / 5,571

62.8 %3,526 / 5,611

65.0 %3,582 / 5,511

68.1 %3,733 / 5,483

67.3 %3,625 / 5,383

61.8 %3,515 / 5,688

62.5 %3,636 / 5,813

4.0 %138 / 3,456

64.5 %2,971 / 4,604

55.5 %2,945 / 5,304

59.9 %3,016 / 5,032

55.5 %2,893 / 5,215

55.5 %2,904 / 5,230

58.4 %3,008 / 5,147

60.2 %3,047 / 5,065

58.2 %3,005 / 5,166

57.4 %3,041 / 5,298

56.1 %2,996 / 5,336

4.3 %165 / 3,851

68.7 %3,364 / 4,900

77.1 %3,582 / 4,648

64.6 %3,288 / 5,088

64.3 %3,300 / 5,132

73.5 %3,505 / 4,769

71.5 %3,495 / 4,886

78.1 %3,576 / 4,581

70.2 %3,462 / 4,932

64.6 %3,415 / 5,283

4.9 %211 / 4,271

66.6 %3,481 / 5,229

63.3 %3,354 / 5,302

62.9 %3,366 / 5,354

68.8 %3,549 / 5,155

64.6 %3,492 / 5,407

66.0 %3,442 / 5,219

59.9 %3,330 / 5,557

63.8 %3,556 / 5,574

5.7 %243 / 4,240

64.4 %3,419 / 5,309

64.4 %3,438 / 5,336

72.1 %3,650 / 5,061

66.1 %3,521 / 5,323

75.5 %3,719 / 4,929

68.6 %3,593 / 5,240

62.3 %3,502 / 5,625

5.9 %253 / 4,264

91.8 %4,114 / 4,480

69.1 %3,576 / 5,175

62.3 %3,426 / 5,495

63.0 %3,371 / 5,349

58.6 %3,297 / 5,625

55.1 %3,282 / 5,957

6.1 %263 / 4,322

69.7 %3,616 / 5,188

62.4 %3,449 / 5,530

62.8 %3,388 / 5,393

58.7 %3,317 / 5,653

55.1 %3,299 / 5,991

4.2 %183 / 4,350

66.5 %3,557 / 5,349

72.1 %3,625 / 5,025

65.6 %3,517 / 5,360

59.0 %3,411 / 5,784

4.4 %198 / 4,465

66.3 %3,514 / 5,302

64.9 %3,541 / 5,459

64.9 %3,649 / 5,620

3.7 %156 / 4,271

66.5 %3,514 / 5,281

61.4 %3,464 / 5,645

4.5 %201 / 4,458

58.0 %3,422 / 5,900

4.6 %216 / 4,733







Escherichia coli HS














Shigella boydii

CDC 3083-94












Escherichia coli

K12 W3110




Escherichia coli A

PECO1




Escherichia coli A

TCC8739


Escherichia coli SM

S3-3-5


Escherichia coli

K12 DH

10B


Escherichia coli

K12 MG

1655


Escherichia coli

0157:H7 str. Sakai


Escherichia coli

0157:H str. ED

L933


Escherichia coli

0157:H str. EC4045


Escherichia coli

0157:H str. EC4206


Escherichia coli

0157:H str. EC4042


Escherichia coli

0157:H str. EC4115


Escherichia coli

0157:H str. EC4196


Escherichia coli

0157:H str. EC4113


Escherichia coli

0157:H str. EC4076


Escherichia coli

0157:H str. EC4401


Escherichia coli

0157:H str. EC4486


Escherichia coli

0157:H str. EC4501


Escherichia coli

0157:H str. EC508


Escherichia coli

0157:H str. EC869


Escherichia coli

0157:H TW

14588






Escherichia coli

0127:H6 str. E2348/69












Escherichia coli U

MN

026


Shigella flexneri

2a str. 2457T







10407


Escherichia coli

LAN

L ECA


Escherichia coli

LAN

L ECF


Escherichia coli O

103 Oslo


Escherichia coli

SECEC SMS35




Escherichia coli

DSM

172521


Escherichia coli

Nissle 1917


Shige

lla d

ysen

teriae

Sd19

7

4,50

5 pro

tein

s, 3,

374

fam

ilies

Shige

lla bo

ydii

Sb22

7

4,28

4 pro

tein

s, 3,

474

fam

ilies

Shige

lla so

nnei

Ss0

46

4,47

5 pro

tein

s, 3,

730

fam

ilies

Esche

richi

a coli

HS

4,38

4 pro

tein

s, 4,

125

fam

ilies

Esche

richi

a coli

E24

377A

4,99

7 pro

tein

s, 4,

611

fam

ilies

Esche

richi

a coli

B7A

4,64

8 pro

tein

s, 4,

340

fam

ilies

Esche

richi

a coli

F11

4,70

4 pro

tein

s, 4,

393

fam

ilies

Esche

richi

a coli

E22

5,10

5 pro

tein

s, 4,

684

fam

ilies

Esche

richi

a coli

E11

0019

4,93

4 pro

tein

s, 4,

419

fam

ilies

Esche

richi

a coli

B17

1

5,01

0 pro

tein

s, 4,

482

fam

ilies

Shige

lla bo

ydii

CD

C 308

3-94

4,55

7 pro

tein

s, 3,

700

fam

ilies

Esche

richi

a coli

536

38

5,17

2 pro

tein

s, 4,

610

fam

ilies

Esche

richi

a coli

101

-1

4,60

7 pro

tein

s, 4,

299

fam

ilies

Shige

lla d

ysen

teriae

101

2

4,41

9 pro

tein

s, 3,

895

fam

ilies

Esche

richi

a coli

536

4,62

9 pro

tein

s, 4,

335

fam

ilies

Esche

richi

a coli

UTI8

9

5,21

1 pro

tein

s, 4,

894

fam

ilies

Esche

richi

a coli

K12

W31

10

4,22

6 pro

tein

s, 3,

965

fam

ilies

Shige

lla fl

exner

i

5 st

r. 84

01

4,11

6 pro

tein

s, 3,

502

fam

ilies

Esche

richi

a coli

APECO

1

4,89

0 pro

tein

s, 4,

559

fam

ilies

Esche

richi

a coli

SE11

5,00

2 pro

tein

s, 4,

663

fam

ilies

Esche

richi

a coli

ATCC87

39

4,20

0 pro

tein

s, 3,

977

fam

ilies

Esche

richi

a coli

SM

S3-3

-5

4,91

3 pro

tein

s, 4,

602

fam

ilies

Esche

richi

a coli

K12

DH

10B

4,12

6 pro

tein

s, 3,

797

fam

ilies

Esche

richi

a coli

K12

MG

1655

4,13

1 pro

tein

s, 3,

894

fam

ilies

Esche

richi

a coli

015

7:H

7 st

r. Sa

kai

5,44

7 pro

tein

s, 4,

795

fam

ilies

Esche

richi

a coli

015

7:H

str.

EDL93

3

5,44

9 pro

tein

s, 4,

765

fam

ilies

Esche

richi

a coli

015

7:H

str.

EC4045

4,78

1 pro

tein

s, 4,

255

fam

ilies

Esche

richi

a coli

015

7:H

str.

EC4206

5,20

2 pro

tein

s, 4,

585

fam

ilies

Esche

richi

a coli

015

7:H

str.

EC4042

5,23

2 pro

tein

s, 4,

615

fam

ilies

Esche

richi

a coli

015

7:H

str.

EC4115

5,47

7 pro

tein

s, 4,

769

fam

ilies

Esche

richi

a coli

015

7:H

str.

EC4196

5,07

2 pro

tein

s, 4,

483

fam

ilies

Esche

richi

a coli

015

7:H

str.

EC4113

5,00

5 pro

tein

s, 4,

438

fam

ilies

Esche

richi

a coli

015

7:H

str.

EC4076

5,24

2 pro

tein

s, 4,

609

fam

ilies

Esche

richi

a coli

015

7:H

str.

EC4401

5,18

5 pro

tein

s, 4,

640

fam

ilies

Esche

richi

a coli

015

7:H

str.

EC4486

5,42

9 pro

tein

s, 4,

774

fam

ilies

Esche

richi

a coli

015

7:H

str.

EC4501

5,12

4 pro

tein

s, 4,

516

fam

ilies

Esche

richi

a coli

015

7:H

str.

EC508

5,01

9 pro

tein

s, 4,

461

fam

ilies

Esche

richi

a coli

015

7:H

str.

EC869

5,22

0 pro

tein

s, 4,

648

fam

ilies

Esche

richi

a coli

015

7:H

TW

1458

8

5,80

3 pro

tein

s, 5,

105

fam

ilies

Shige

lla fl

exner

i

2a

str.

301

4,44

5 pro

tein

s, 3,

667

fam

ilies

Esche

richi

a coli

CFT07

3

5,37

9 pro

tein

s, 4,

953

fam

ilies

Esche

richi

a coli

012

7:H

6 st

r. E23

48/69

4,65

3 pro

tein

s, 4,

327

fam

ilies

Esche

richi

a coli

IAI1

4,35

4 pro

tein

s, 4,

143

fam

ilies

Esche

richi

a coli

S88

4,69

6 pro

tein

s, 4,

371

fam

ilies

Esche

richi

a coli

ED

1a

4,91

5 pro

tein

s, 4,

451

fam

ilies

Esche

richi

a coli

IAI3

9

4,73

2 pro

tein

s, 4,

244

fam

ilies

Esche

richi

a coli

559

89

4,76

3 pro

tein

s, 4,

376

fam

ilies

Esche

richi

a coli

UM

N02

6

4,96

8 pro

tein

s, 4,

632

fam

ilies

Shige

lla fl

exner

i

2a

str.

2457

T

4,06

8 pro

tein

s, 3,

456

fam

ilies

Esche

richi

a coli

B03

4,07

6 pro

tein

s, 3,

851

fam

ilies

Esche

richi

a coli

E23

48

4,59

2 pro

tein

s, 4,

271

fam

ilies

Esche

richi

a coli

EcH

1040

7

4,61

2 pro

tein

s, 4,

240

fam

ilies

Esche

richi

a coli

LA

NL E

CA

4,75

0 pro

tein

s, 4,

264

fam

ilies

Esche

richi

a coli

LA

NL E

CF

4,81

3 pro

tein

s, 4,

322

fam

ilies

Esche

richi

a coli

O10

3 O

slo

4,57

1 pro

tein

s, 4,

350

fam

ilies

Esche

richi

a coli

SECEC S

MS3

5

4,74

3 pro

tein

s, 4,

465

fam

ilies

Esche

richi

a coli

VR50

4,45

3 pro

tein

s, 4,

271

fam

ilies

Esche

richi

a coli

DSM

1725

21

4,71

1 pro

tein

s, 4,

458

fam

ilies

Esche

richi

a coli

Niss

le 1

917

5,05

3 pro

tein

s, 4,

733

fam

ilies


8.1 %3.3 %


96.9 %40.9 %

3.4 %115 / 3,374

58.0 %2,701 / 4,658

61.8 %2,839 / 4,591

49.7 %2,766 / 5,563

50.9 %2,836 / 5,575

45.7 %2,612 / 5,711

43.6 %2,693 / 6,173

40.9 %2,701 / 6,596

44.2 %2,690 / 6,088

45.5 %2,668 / 5,870

53.7 %2,692 / 5,010

51.5 %2,845 / 5,526

46.3 %2,700 / 5,832

49.5 %2,575 / 5,203

47.1 %2,796 / 5,931

47.9 %2,844 / 5,942

53.8 %2,818 / 5,236

58.9 %2,667 / 4,528

45.5 %2,650 / 5,823

50.7 %2,865 / 5,655

51.8 %2,803 / 5,416

49.3 %2,869 / 5,821

53.0 %2,740 / 5,169

53.9 %2,801 / 5,197

50.5 %2,947 / 5,837

49.2 %2,952 / 5,995

42.7 %2,581 / 6,049

43.9 %2,748 / 6,260

44.8 %2,794 / 6,243

44.8 %2,865 / 6,401

43.1 %2,682 / 6,216

42.7 %2,642 / 6,190

45.0 %2,810 / 6,240

42.7 %2,740 / 6,411

43.4 %2,792 / 6,438

41.9 %2,638 / 6,301

42.0 %2,629 / 6,257

44.6 %2,787 / 6,252

47.1 %2,930 / 6,218

61.1 %2,759 / 4,518

44.9 %2,794 / 6,224

49.0 %2,804 / 5,726

48.7 %2,825 / 5,799

51.4 %2,812 / 5,471

50.1 %2,789 / 5,565

50.4 %2,803 / 5,558

52.0 %2,838 / 5,456

50.0 %2,886 / 5,771

59.8 %2,636 / 4,405

52.8 %2,752 / 5,215

48.8 %2,776 / 5,685

48.8 %2,791 / 5,714

47.5 %2,762 / 5,813

47.7 %2,778 / 5,828

48.0 %2,791 / 5,816

50.4 %2,861 / 5,681

47.1 %2,768 / 5,876

49.8 %2,800 / 5,622

50.9 %2,831 / 5,559

3.6 %126 / 3,474

68.1 %3,014 / 4,429

58.3 %3,014 / 5,171

55.2 %3,044 / 5,517

54.0 %2,880 / 5,335

51.1 %2,879 / 5,631

49.7 %2,975 / 5,991

55.2 %2,960 / 5,363

51.6 %2,905 / 5,632

68.5 %2,981 / 4,352

57.7 %3,104 / 5,379

56.6 %2,955 / 5,225

55.7 %2,736 / 4,913

54.5 %2,969 / 5,444

53.2 %3,066 / 5,763

62.1 %3,047 / 4,910

66.9 %2,838 / 4,239

51.2 %2,868 / 5,603

58.1 %3,140 / 5,409

62.5 %3,070 / 4,912

57.1 %3,080 / 5,391

60.5 %2,934 / 4,848

62.2 %3,024 / 4,865

54.3 %3,101 / 5,710

54.3 %3,103 / 5,710

49.7 %2,734 / 5,497

51.4 %2,922 / 5,682

52.3 %2,964 / 5,664

52.2 %3,036 / 5,814

50.8 %2,861 / 5,634

50.1 %2,816 / 5,617

52.6 %2,980 / 5,661

49.0 %2,890 / 5,902

50.4 %2,963 / 5,878

48.7 %2,796 / 5,742

49.2 %2,799 / 5,688

52.9 %2,984 / 5,644

50.4 %3,073 / 6,099

65.0 %2,884 / 4,440

51.8 %3,027 / 5,842

55.5 %3,036 / 5,466

58.1 %3,069 / 5,286

57.4 %3,035 / 5,290

55.4 %3,019 / 5,450

58.9 %3,019 / 5,124

58.0 %3,092 / 5,334

56.5 %3,073 / 5,440

63.6 %2,813 / 4,420

63.0 %2,998 / 4,757

56.1 %3,012 / 5,369

59.0 %3,037 / 5,144

55.3 %2,910 / 5,262

55.8 %2,939 / 5,264

57.6 %3,079 / 5,342

58.6 %3,072 / 5,246

55.1 %2,992 / 5,429

56.4 %3,054 / 5,416

54.7 %3,020 / 5,520

4.6 %172 / 3,730

61.3 %3,171 / 5,172

60.7 %3,276 / 5,401

56.0 %3,053 / 5,452

53.2 %3,040 / 5,711

53.0 %3,163 / 5,963

57.4 %3,122 / 5,439

55.1 %3,091 / 5,614

61.5 %2,951 / 4,795

62.1 %3,267 / 5,264

59.2 %3,119 / 5,270

58.4 %2,880 / 4,929

56.0 %3,126 / 5,585

54.9 %3,204 / 5,836

66.4 %3,223 / 4,852

66.8 %2,994 / 4,485

52.7 %3,009 / 5,714

61.1 %3,332 / 5,455

66.3 %3,228 / 4,866

59.2 %3,232 / 5,456

65.0 %3,115 / 4,790

66.8 %3,205 / 4,795

57.6 %3,277 / 5,690

57.7 %3,286 / 5,691

52.0 %2,874 / 5,529

54.1 %3,073 / 5,678

54.8 %3,113 / 5,677

55.0 %3,192 / 5,805

53.3 %3,003 / 5,629

52.5 %2,959 / 5,635

55.3 %3,130 / 5,662

51.7 %3,057 / 5,908

52.9 %3,117 / 5,891

51.2 %2,942 / 5,750

51.7 %2,943 / 5,691

54.8 %3,121 / 5,700

53.8 %3,258 / 6,053

67.6 %3,052 / 4,514

53.2 %3,136 / 5,892

55.4 %3,127 / 5,643

63.1 %3,285 / 5,203

58.5 %3,168 / 5,412

57.1 %3,139 / 5,496

61.9 %3,159 / 5,101

62.3 %3,283 / 5,266

62.7 %3,307 / 5,272

66.0 %2,925 / 4,435

66.7 %3,132 / 4,695

55.6 %3,103 / 5,580

62.1 %3,204 / 5,158

58.3 %3,073 / 5,272

58.3 %3,085 / 5,289

61.3 %3,228 / 5,266

60.2 %3,206 / 5,330

60.1 %3,190 / 5,312

58.8 %3,230 / 5,496

56.2 %3,149 / 5,603

3.3 %137 / 4,125

70.8 %3,686 / 5,208

63.7 %3,360 / 5,277

60.3 %3,283 / 5,443

62.1 %3,485 / 5,611

62.9 %3,420 / 5,435

60.2 %3,366 / 5,596

54.3 %2,929 / 5,394

63.7 %3,533 / 5,545

65.6 %3,395 / 5,173

53.2 %2,943 / 5,537

63.9 %3,379 / 5,288

61.1 %3,488 / 5,708

75.6 %3,531 / 4,670

61.1 %3,045 / 4,983

57.3 %3,234 / 5,644

69.9 %3,671 / 5,255

77.5 %3,572 / 4,612

65.7 %3,528 / 5,366

72.7 %3,385 / 4,659

75.8 %3,503 / 4,621

57.7 %3,421 / 5,929

58.6 %3,460 / 5,907

53.7 %3,063 / 5,702

56.3 %3,297 / 5,853

57.1 %3,337 / 5,842

57.1 %3,418 / 5,981

55.7 %3,231 / 5,798

54.8 %3,177 / 5,795

57.6 %3,357 / 5,832

55.6 %3,278 / 5,891

55.4 %3,338 / 6,029

53.2 %3,157 / 5,930

54.6 %3,176 / 5,820

57.2 %3,336 / 5,828

56.4 %3,496 / 6,197

58.2 %3,031 / 5,209

58.3 %3,444 / 5,906

62.4 %3,336 / 5,350

74.5 %3,579 / 4,805

66.4 %3,462 / 5,212

60.8 %3,347 / 5,505

64.3 %3,399 / 5,287

70.3 %3,582 / 5,092

63.7 %3,476 / 5,461

61.0 %2,989 / 4,902

75.3 %3,460 / 4,597

61.8 %3,300 / 5,337

69.6 %3,517 / 5,054

59.2 %3,241 / 5,477

59.1 %3,256 / 5,513

68.2 %3,498 / 5,131

67.8 %3,528 / 5,202

69.6 %3,501 / 5,029

68.7 %3,555 / 5,173

62.1 %3,453 / 5,563

5.0 %232 / 4,611

65.7 %3,604 / 5,483

59.4 %3,413 / 5,747

63.1 %3,686 / 5,846

63.4 %3,601 / 5,676

62.9 %3,604 / 5,732

53.0 %3,020 / 5,703

62.4 %3,636 / 5,830

65.3 %3,568 / 5,468

52.9 %3,070 / 5,807

61.2 %3,469 / 5,670

59.1 %3,588 / 6,072

68.8 %3,566 / 5,180

58.0 %3,110 / 5,362

55.0 %3,330 / 6,056

71.0 %3,903 / 5,495

68.5 %3,564 / 5,203

64.3 %3,655 / 5,684

66.4 %3,428 / 5,163

68.8 %3,536 / 5,142

57.6 %3,574 / 6,205

58.5 %3,607 / 6,164

54.6 %3,244 / 5,945

57.4 %3,483 / 6,066

58.1 %3,522 / 6,060

58.3 %3,600 / 6,180

56.5 %3,414 / 6,041

55.7 %3,358 / 6,034

58.4 %3,544 / 6,069

56.7 %3,467 / 6,113

56.9 %3,541 / 6,221

54.1 %3,337 / 6,173

55.0 %3,348 / 6,086

57.7 %3,518 / 6,096

57.2 %3,682 / 6,435

56.7 %3,107 / 5,484

56.5 %3,541 / 6,264

59.4 %3,425 / 5,769

71.2 %3,721 / 5,229

61.7 %3,511 / 5,690

58.1 %3,431 / 5,902

61.0 %3,471 / 5,690

69.5 %3,744 / 5,388

63.1 %3,632 / 5,759

57.7 %3,039 / 5,269

68.0 %3,501 / 5,146

59.3 %3,400 / 5,733

65.7 %3,588 / 5,465

58.7 %3,391 / 5,772

58.8 %3,412 / 5,805

65.7 %3,622 / 5,509

65.2 %3,629 / 5,570

65.3 %3,575 / 5,475

65.0 %3,631 / 5,588

59.3 %3,543 / 5,977

5.2 %226 / 4,340

60.1 %3,329 / 5,541

69.5 %3,766 / 5,416

67.6 %3,599 / 5,324

65.7 %3,564 / 5,427

50.9 %2,844 / 5,588

61.4 %3,509 / 5,713

68.2 %3,538 / 5,185

53.4 %3,003 / 5,625

57.5 %3,223 / 5,606

58.2 %3,441 / 5,908

65.6 %3,339 / 5,090

55.3 %2,913 / 5,267

54.1 %3,177 / 5,873

68.5 %3,691 / 5,386

65.4 %3,337 / 5,101

62.7 %3,488 / 5,563

63.6 %3,216 / 5,060

65.9 %3,321 / 5,036

55.4 %3,362 / 6,067

56.2 %3,391 / 6,039

54.7 %3,115 / 5,694

58.6 %3,381 / 5,769

58.9 %3,406 / 5,785

58.2 %3,455 / 5,939

59.4 %3,366 / 5,671

58.6 %3,322 / 5,673

59.1 %3,416 / 5,778

58.2 %3,384 / 5,811

58.1 %3,437 / 5,913

56.7 %3,301 / 5,824

58.5 %3,324 / 5,682

60.0 %3,446 / 5,748

56.3 %3,518 / 6,247

52.3 %2,894 / 5,536

52.8 %3,279 / 6,212

58.3 %3,260 / 5,590

67.9 %3,477 / 5,120

60.1 %3,320 / 5,528

55.5 %3,223 / 5,811

59.9 %3,302 / 5,517

66.0 %3,525 / 5,339

61.3 %3,457 / 5,640

53.5 %2,837 / 5,304

64.8 %3,268 / 5,044

58.2 %3,237 / 5,564

63.8 %3,394 / 5,321

57.0 %3,201 / 5,614

56.7 %3,208 / 5,653

64.2 %3,437 / 5,356

62.7 %3,436 / 5,476

63.0 %3,376 / 5,359

61.4 %3,391 / 5,525

56.0 %3,307 / 5,902

5.3 %232 / 4,393

58.8 %3,430 / 5,838

59.9 %3,392 / 5,661

58.0 %3,351 / 5,776

48.5 %2,857 / 5,890

58.6 %3,447 / 5,883

63.0 %3,426 / 5,438

51.2 %2,943 / 5,744

77.2 %3,823 / 4,952

71.9 %3,919 / 5,447

62.7 %3,282 / 5,237

52.7 %2,908 / 5,513

62.4 %3,499 / 5,606

59.2 %3,425 / 5,787

63.1 %3,290 / 5,214

65.2 %3,597 / 5,519

60.7 %3,158 / 5,205

63.4 %3,274 / 5,163

53.7 %3,329 / 6,202

54.3 %3,354 / 6,174

51.9 %3,048 / 5,868

55.2 %3,298 / 5,980

55.9 %3,340 / 5,973

55.4 %3,397 / 6,132

55.5 %3,264 / 5,884

54.5 %3,214 / 5,895

56.3 %3,353 / 5,957

55.1 %3,298 / 5,989

54.8 %3,356 / 6,120

53.3 %3,208 / 6,022

54.7 %3,219 / 5,885

56.2 %3,349 / 5,961

54.1 %3,467 / 6,414

50.9 %2,922 / 5,736

66.9 %3,786 / 5,656

64.2 %3,477 / 5,412

63.5 %3,365 / 5,296

69.5 %3,636 / 5,232

62.6 %3,508 / 5,603

63.9 %3,419 / 5,354

61.1 %3,392 / 5,552

62.1 %3,499 / 5,633

52.1 %2,866 / 5,505

63.4 %3,248 / 5,127

64.7 %3,466 / 5,361

61.9 %3,360 / 5,426

55.5 %3,178 / 5,730

55.5 %3,195 / 5,759

60.2 %3,327 / 5,526

65.5 %3,549 / 5,416

61.9 %3,347 / 5,406

58.2 %3,305 / 5,682

69.3 %3,767 / 5,435

5.3 %246 / 4,684

69.0 %3,777 / 5,471

70.4 %3,843 / 5,459

48.8 %2,978 / 6,105

60.7 %3,651 / 6,018

65.3 %3,625 / 5,548

52.4 %3,100 / 5,912

57.4 %3,359 / 5,850

57.6 %3,559 / 6,181

64.0 %3,461 / 5,407

52.5 %3,025 / 5,761

54.0 %3,309 / 6,129

68.3 %3,848 / 5,632

63.9 %3,449 / 5,401

61.1 %3,608 / 5,906

62.1 %3,334 / 5,369

64.1 %3,436 / 5,357

58.5 %3,575 / 6,107

59.2 %3,606 / 6,091

57.6 %3,321 / 5,767

61.6 %3,591 / 5,831

61.8 %3,613 / 5,845

61.8 %3,675 / 5,951

61.8 %3,562 / 5,762

61.0 %3,520 / 5,766

61.8 %3,614 / 5,852

60.9 %3,588 / 5,894

60.7 %3,646 / 6,010

59.7 %3,510 / 5,882

60.7 %3,512 / 5,784

62.9 %3,663 / 5,822

60.1 %3,755 / 6,246

49.7 %3,003 / 6,042

53.2 %3,427 / 6,438

60.3 %3,450 / 5,726

67.0 %3,605 / 5,380

60.0 %3,452 / 5,749

56.0 %3,361 / 5,997

58.8 %3,428 / 5,826

65.2 %3,647 / 5,592

60.5 %3,572 / 5,904

50.8 %2,937 / 5,787

62.7 %3,372 / 5,382

59.6 %3,411 / 5,720

63.3 %3,523 / 5,564

59.4 %3,396 / 5,717

58.5 %3,387 / 5,790

65.6 %3,637 / 5,547

61.9 %3,574 / 5,777

61.3 %3,467 / 5,653

60.3 %3,502 / 5,803

55.7 %3,441 / 6,183

6.9 %303 / 4,419

67.4 %3,656 / 5,423

53.9 %2,969 / 5,507

61.4 %3,553 / 5,787

66.1 %3,544 / 5,363

55.7 %3,127 / 5,611

57.8 %3,297 / 5,703

57.5 %3,472 / 6,039

63.1 %3,362 / 5,328

56.0 %2,985 / 5,328

54.0 %3,227 / 5,977

66.0 %3,676 / 5,567

64.7 %3,397 / 5,249

63.1 %3,563 / 5,644

61.4 %3,243 / 5,283

63.2 %3,340 / 5,282

61.3 %3,555 / 5,798

62.5 %3,583 / 5,736

60.6 %3,315 / 5,474

65.4 %3,602 / 5,508

65.5 %3,621 / 5,528

65.3 %3,685 / 5,639

65.6 %3,570 / 5,443

64.9 %3,528 / 5,438

65.7 %3,624 / 5,517

63.4 %3,557 / 5,610

62.9 %3,615 / 5,750

63.4 %3,518 / 5,547

63.9 %3,505 / 5,487

65.4 %3,626 / 5,542

63.4 %3,753 / 5,924

53.3 %2,974 / 5,580

54.2 %3,376 / 6,224

60.6 %3,369 / 5,560

66.0 %3,496 / 5,295

60.1 %3,376 / 5,615

58.4 %3,331 / 5,707

59.2 %3,342 / 5,649

66.6 %3,599 / 5,402

60.6 %3,489 / 5,759

54.6 %2,918 / 5,344

62.4 %3,291 / 5,271

60.2 %3,341 / 5,546

62.6 %3,424 / 5,468

62.0 %3,374 / 5,440

61.5 %3,380 / 5,497

67.3 %3,606 / 5,356

63.3 %3,515 / 5,556

61.4 %3,406 / 5,547

60.2 %3,415 / 5,672

56.8 %3,396 / 5,976

6.8 %305 / 4,482

50.8 %2,909 / 5,729

60.1 %3,541 / 5,896

64.7 %3,525 / 5,448

52.7 %3,047 / 5,787

55.5 %3,250 / 5,858

55.9 %3,428 / 6,130

62.1 %3,361 / 5,408

53.5 %2,946 / 5,502

51.6 %3,164 / 6,136

65.0 %3,679 / 5,656

62.5 %3,363 / 5,380

59.0 %3,474 / 5,887

60.0 %3,228 / 5,378

62.4 %3,341 / 5,356

57.4 %3,493 / 6,089

57.8 %3,514 / 6,084

55.9 %3,231 / 5,779

60.0 %3,497 / 5,824

60.4 %3,528 / 5,837

60.3 %3,592 / 5,958

60.2 %3,469 / 5,762

59.5 %3,427 / 5,761

60.0 %3,524 / 5,872

58.6 %3,475 / 5,928

57.9 %3,513 / 6,072

58.3 %3,425 / 5,870

59.1 %3,413 / 5,777

60.8 %3,549 / 5,838

58.6 %3,664 / 6,252

51.8 %2,954 / 5,701

52.1 %3,332 / 6,394

59.5 %3,370 / 5,665

65.1 %3,506 / 5,383

58.2 %3,337 / 5,735

54.2 %3,255 / 6,011

57.3 %3,328 / 5,807

64.3 %3,545 / 5,514

58.0 %3,427 / 5,905

52.2 %2,881 / 5,516

60.8 %3,266 / 5,376

59.1 %3,334 / 5,643

62.8 %3,444 / 5,481

58.2 %3,315 / 5,699

57.3 %3,300 / 5,762

63.2 %3,503 / 5,541

59.6 %3,443 / 5,776

58.8 %3,345 / 5,693

58.5 %3,396 / 5,804

54.3 %3,334 / 6,141

4.5 %168 / 3,700

56.0 %3,109 / 5,555

53.7 %2,939 / 5,474

54.5 %2,777 / 5,100

50.6 %2,899 / 5,724

50.4 %3,009 / 5,966

55.9 %2,923 / 5,231

60.4 %2,778 / 4,598

47.8 %2,785 / 5,823

54.1 %3,070 / 5,678

55.9 %2,946 / 5,267

53.8 %3,025 / 5,623

54.6 %2,827 / 5,176

55.9 %2,910 / 5,205

49.7 %2,968 / 5,971

50.0 %2,984 / 5,973

48.1 %2,717 / 5,651

50.0 %2,904 / 5,812

50.8 %2,946 / 5,800

51.1 %3,027 / 5,918

49.1 %2,833 / 5,775

48.2 %2,787 / 5,777

51.0 %2,954 / 5,793

47.3 %2,878 / 6,081

48.9 %2,951 / 6,039

47.3 %2,781 / 5,878

47.7 %2,784 / 5,831

51.1 %2,968 / 5,806

49.3 %3,066 / 6,218

60.7 %2,855 / 4,700

48.7 %2,972 / 6,098

51.2 %2,933 / 5,728

53.4 %2,983 / 5,589

53.5 %2,950 / 5,509

52.3 %2,936 / 5,609

52.9 %2,911 / 5,500

54.7 %3,001 / 5,491

52.9 %2,992 / 5,656

58.3 %2,733 / 4,684

56.3 %2,877 / 5,112

51.2 %2,911 / 5,691

54.3 %2,950 / 5,429

51.1 %2,826 / 5,527

51.3 %2,848 / 5,553

53.0 %2,967 / 5,596

54.9 %3,014 / 5,486

50.8 %2,917 / 5,747

52.4 %2,989 / 5,701

51.5 %2,972 / 5,770

6.6 %302 / 4,610

64.7 %3,584 / 5,536

57.4 %3,175 / 5,530

57.1 %3,391 / 5,934

56.4 %3,528 / 6,258

64.9 %3,504 / 5,401

58.1 %3,101 / 5,336

53.5 %3,293 / 6,154

64.0 %3,716 / 5,810

67.3 %3,587 / 5,330

63.5 %3,679 / 5,791

63.1 %3,381 / 5,355

65.1 %3,483 / 5,347

54.4 %3,480 / 6,393

54.5 %3,486 / 6,394

51.9 %3,176 / 6,118

55.2 %3,428 / 6,210

55.8 %3,466 / 6,207

56.0 %3,545 / 6,328

54.3 %3,351 / 6,170

53.6 %3,307 / 6,172

56.3 %3,485 / 6,195

53.8 %3,390 / 6,304

54.1 %3,460 / 6,390

52.2 %3,288 / 6,297

52.9 %3,291 / 6,219

55.9 %3,471 / 6,207

54.9 %3,621 / 6,590

58.5 %3,149 / 5,379

53.2 %3,445 / 6,481

57.0 %3,387 / 5,945

63.7 %3,557 / 5,582

58.7 %3,450 / 5,875

56.0 %3,396 / 6,062

59.6 %3,443 / 5,774

61.7 %3,564 / 5,778

60.0 %3,565 / 5,941

58.0 %3,053 / 5,267

64.4 %3,437 / 5,333

57.1 %3,364 / 5,890

64.0 %3,567 / 5,571

55.1 %3,288 / 5,968

55.0 %3,297 / 5,999

61.5 %3,528 / 5,739

63.5 %3,633 / 5,719

62.3 %3,534 / 5,672

61.3 %3,567 / 5,820

55.5 %3,451 / 6,219

5.2 %224 / 4,299

55.6 %3,053 / 5,491

60.7 %3,332 / 5,487

60.8 %3,522 / 5,793

70.0 %3,451 / 4,932

57.5 %2,967 / 5,161

57.2 %3,282 / 5,738

66.1 %3,610 / 5,462

69.7 %3,440 / 4,935

65.7 %3,580 / 5,450

67.7 %3,321 / 4,904

70.2 %3,425 / 4,882

57.2 %3,413 / 5,962

57.8 %3,438 / 5,943

54.8 %3,111 / 5,682

59.2 %3,395 / 5,733

59.6 %3,422 / 5,742

59.3 %3,487 / 5,880

60.0 %3,380 / 5,634

59.3 %3,336 / 5,628

59.5 %3,426 / 5,760

57.6 %3,365 / 5,843

57.5 %3,421 / 5,953

57.8 %3,326 / 5,752

58.7 %3,321 / 5,659

60.9 %3,469 / 5,700

58.0 %3,566 / 6,149

54.7 %2,959 / 5,414

56.8 %3,435 / 6,044

61.1 %3,345 / 5,478

67.0 %3,446 / 5,141

63.5 %3,423 / 5,390

59.2 %3,348 / 5,659

62.0 %3,354 / 5,407

65.4 %3,492 / 5,339

63.4 %3,514 / 5,542

55.7 %2,896 / 5,199

71.8 %3,444 / 4,796

61.0 %3,320 / 5,447

67.5 %3,491 / 5,170

58.6 %3,243 / 5,535

58.1 %3,243 / 5,584

64.3 %3,441 / 5,348

65.6 %3,523 / 5,371

65.4 %3,436 / 5,256

63.2 %3,449 / 5,458

59.2 %3,422 / 5,777

4.1 %159 / 3,895

51.0 %2,905 / 5,697

49.1 %3,015 / 6,146

57.2 %2,983 / 5,216

55.6 %2,767 / 4,979

46.4 %2,802 / 6,033

53.3 %3,114 / 5,840

57.0 %2,999 / 5,261

55.5 %3,114 / 5,615

56.4 %2,900 / 5,146

57.8 %2,976 / 5,146

49.2 %3,029 / 6,154

49.7 %3,043 / 6,119

46.8 %2,766 / 5,910

49.9 %3,011 / 6,037

50.0 %3,024 / 6,054

49.9 %3,090 / 6,195

50.3 %2,988 / 5,946

49.6 %2,941 / 5,924

49.9 %3,024 / 6,055

48.5 %2,962 / 6,110

48.5 %3,024 / 6,237

48.8 %2,939 / 6,027

49.5 %2,948 / 5,951

50.7 %3,047 / 6,011

49.2 %3,140 / 6,376

57.9 %2,844 / 4,909

47.8 %2,960 / 6,193

50.6 %2,929 / 5,785

54.9 %3,009 / 5,476

51.1 %2,932 / 5,734

49.4 %2,931 / 5,930

52.2 %2,942 / 5,631

54.7 %3,084 / 5,635

52.2 %3,039 / 5,824

54.9 %2,728 / 4,972

56.6 %2,914 / 5,146

52.0 %2,922 / 5,621

54.3 %3,005 / 5,531

51.0 %2,884 / 5,653

51.2 %2,901 / 5,667

54.9 %3,013 / 5,486

55.8 %3,076 / 5,516

53.6 %2,977 / 5,551

54.4 %3,046 / 5,604

50.7 %2,979 / 5,873

4.4 %192 / 4,335

73.5 %3,943 / 5,363

67.2 %3,401 / 5,059

56.1 %3,002 / 5,355

65.9 %3,594 / 5,452

62.4 %3,520 / 5,645

67.4 %3,404 / 5,052

65.3 %3,568 / 5,466

65.4 %3,277 / 5,013

67.9 %3,389 / 4,991

56.3 %3,413 / 6,059

57.1 %3,440 / 6,028

51.6 %3,026 / 5,863

54.2 %3,250 / 5,994

54.9 %3,290 / 5,990

55.0 %3,372 / 6,130

53.7 %3,183 / 5,924

52.7 %3,133 / 5,942

55.5 %3,312 / 5,971

53.6 %3,230 / 6,028

53.4 %3,296 / 6,176

51.7 %3,130 / 6,058

52.7 %3,130 / 5,939

54.7 %3,286 / 6,002

54.0 %3,449 / 6,387

54.2 %3,009 / 5,551

70.6 %3,875 / 5,491

67.0 %3,527 / 5,268

67.1 %3,461 / 5,160

74.8 %3,771 / 5,039

67.2 %3,634 / 5,404

68.0 %3,518 / 5,175

65.6 %3,519 / 5,363

64.0 %3,533 / 5,523

55.8 %2,964 / 5,315

68.5 %3,375 / 4,930

67.7 %3,521 / 5,200

64.8 %3,438 / 5,302

58.2 %3,254 / 5,593

58.1 %3,272 / 5,631

62.9 %3,397 / 5,404

67.2 %3,567 / 5,309

64.8 %3,418 / 5,276

60.7 %3,370 / 5,552

74.3 %3,886 / 5,228

4.8 %236 / 4,894

62.2 %3,456 / 5,558

53.3 %3,056 / 5,731

70.5 %3,940 / 5,592

60.9 %3,665 / 6,020

62.0 %3,444 / 5,557

63.4 %3,730 / 5,880

59.9 %3,319 / 5,540

62.7 %3,442 / 5,491

56.0 %3,569 / 6,377

56.4 %3,591 / 6,362

50.8 %3,159 / 6,220

54.2 %3,416 / 6,300

54.7 %3,448 / 6,304

55.1 %3,534 / 6,412

53.2 %3,336 / 6,265

52.3 %3,284 / 6,281

54.8 %3,451 / 6,302

52.9 %3,373 / 6,380

53.0 %3,445 / 6,502

51.2 %3,279 / 6,401

52.4 %3,289 / 6,280

55.4 %3,484 / 6,289

53.9 %3,612 / 6,698

52.2 %3,070 / 5,882

73.2 %4,184 / 5,719

65.2 %3,686 / 5,652

61.9 %3,502 / 5,654

76.4 %4,034 / 5,278

64.7 %3,742 / 5,786

63.9 %3,613 / 5,653

62.7 %3,619 / 5,771

63.8 %3,747 / 5,872

53.6 %3,017 / 5,626

61.8 %3,392 / 5,485

64.3 %3,635 / 5,654

61.8 %3,531 / 5,717

55.6 %3,347 / 6,016

55.2 %3,353 / 6,069

60.1 %3,509 / 5,834

63.4 %3,674 / 5,796

61.4 %3,520 / 5,737

57.3 %3,457 / 6,034

73.2 %4,101 / 5,603

4.3 %170 / 3,965

66.0 %3,098 / 4,692

60.2 %3,262 / 5,419

72.6 %3,680 / 5,068

83.3 %3,629 / 4,359

68.7 %3,526 / 5,136

93.1 %3,742 / 4,020

95.9 %3,848 / 4,011

63.0 %3,544 / 5,628

63.3 %3,559 / 5,622

55.9 %3,079 / 5,512

58.6 %3,314 / 5,660

59.4 %3,355 / 5,648

59.6 %3,440 / 5,774

58.0 %3,250 / 5,604

57.1 %3,196 / 5,593

59.9 %3,378 / 5,636

57.7 %3,288 / 5,695

57.5 %3,358 / 5,841

56.1 %3,199 / 5,706

56.6 %3,188 / 5,635

59.5 %3,359 / 5,644

58.8 %3,531 / 6,005

62.9 %3,086 / 4,905

59.2 %3,409 / 5,755

66.1 %3,376 / 5,111

78.2 %3,604 / 4,606

69.1 %3,474 / 5,030

63.8 %3,375 / 5,293

68.9 %3,455 / 5,017

74.0 %3,618 / 4,889

70.0 %3,588 / 5,128

66.3 %3,048 / 4,598

82.5 %3,562 / 4,316

65.3 %3,333 / 5,105

76.7 %3,631 / 4,733

63.9 %3,330 / 5,208

63.8 %3,344 / 5,241

71.6 %3,512 / 4,905

70.8 %3,524 / 4,979

77.1 %3,623 / 4,702

71.3 %3,541 / 4,966

64.4 %3,459 / 5,373

4.6 %160 / 3,502

52.8 %2,902 / 5,498

59.8 %3,180 / 5,316

65.1 %3,088 / 4,741

59.0 %3,122 / 5,292

64.4 %2,991 / 4,646

66.3 %3,079 / 4,646

55.5 %3,132 / 5,647

55.6 %3,143 / 5,652

51.3 %2,775 / 5,411

52.8 %2,958 / 5,597

53.7 %2,999 / 5,589

53.7 %3,076 / 5,730

52.3 %2,896 / 5,535

51.3 %2,846 / 5,544

54.1 %3,016 / 5,575

51.0 %2,931 / 5,746

51.8 %2,999 / 5,793

50.2 %2,839 / 5,651

50.9 %2,843 / 5,585

53.8 %3,008 / 5,590

52.8 %3,151 / 5,969

80.1 %3,212 / 4,012

52.0 %3,013 / 5,789

56.0 %3,001 / 5,358

62.2 %3,126 / 5,022

58.0 %3,044 / 5,244

55.3 %2,991 / 5,408

61.5 %3,060 / 4,974

61.1 %3,143 / 5,141

60.0 %3,144 / 5,238

81.0 %3,155 / 3,897

66.3 %3,033 / 4,576

56.6 %2,999 / 5,300

62.0 %3,097 / 4,993

58.0 %2,987 / 5,153

57.9 %2,994 / 5,174

60.7 %3,095 / 5,103

60.8 %3,122 / 5,138

59.8 %3,068 / 5,129

59.6 %3,129 / 5,250

55.0 %3,021 / 5,496

5.3 %240 / 4,559

56.7 %3,396 / 5,993

60.0 %3,261 / 5,439

61.1 %3,511 / 5,746

57.7 %3,126 / 5,414

60.4 %3,245 / 5,369

53.5 %3,353 / 6,271

53.6 %3,358 / 6,270

49.0 %2,973 / 6,072

51.1 %3,178 / 6,217

51.5 %3,205 / 6,219

52.0 %3,291 / 6,333

50.3 %3,111 / 6,180

49.6 %3,064 / 6,177

52.0 %3,225 / 6,203

50.1 %3,149 / 6,290

50.0 %3,213 / 6,432

48.2 %3,046 / 6,320

49.5 %3,065 / 6,190

51.8 %3,229 / 6,231

50.4 %3,346 / 6,637

51.0 %2,892 / 5,674

62.5 %3,703 / 5,923

62.0 %3,468 / 5,591

58.6 %3,274 / 5,583

74.6 %3,841 / 5,146

62.4 %3,537 / 5,668

62.2 %3,428 / 5,510

59.1 %3,386 / 5,726

59.8 %3,483 / 5,820

52.4 %2,844 / 5,427

62.0 %3,268 / 5,273

63.6 %3,498 / 5,497

61.4 %3,402 / 5,537

54.9 %3,195 / 5,815

54.5 %3,199 / 5,871

60.2 %3,390 / 5,631

60.6 %3,442 / 5,677

60.4 %3,368 / 5,579

54.9 %3,254 / 5,925

62.7 %3,630 / 5,794

5.2 %241 / 4,663

72.2 %3,662 / 5,073

64.6 %3,694 / 5,717

70.0 %3,535 / 5,050

72.3 %3,642 / 5,038

61.9 %3,714 / 6,001

62.2 %3,731 / 5,997

55.8 %3,276 / 5,870

59.3 %3,531 / 5,954

59.9 %3,568 / 5,956

60.4 %3,657 / 6,058

58.6 %3,462 / 5,904

57.5 %3,407 / 5,921

60.3 %3,583 / 5,945

59.6 %3,552 / 5,958

60.0 %3,628 / 6,044

57.1 %3,431 / 6,008

57.3 %3,401 / 5,935

60.2 %3,587 / 5,955

60.2 %3,781 / 6,283

58.4 %3,190 / 5,460

56.5 %3,553 / 6,284

62.0 %3,511 / 5,662

75.8 %3,821 / 5,041

62.9 %3,545 / 5,639

59.7 %3,493 / 5,854

63.2 %3,547 / 5,611

72.2 %3,839 / 5,319

65.4 %3,714 / 5,677

59.4 %3,115 / 5,245

69.8 %3,555 / 5,091

61.4 %3,471 / 5,651

68.8 %3,692 / 5,367

62.2 %3,495 / 5,622

61.4 %3,489 / 5,680

69.3 %3,731 / 5,387

65.0 %3,656 / 5,622

68.2 %3,659 / 5,364

66.2 %3,673 / 5,549

60.0 %3,582 / 5,973

3.9 %156 / 3,977

69.9 %3,575 / 5,111

80.9 %3,497 / 4,322

83.9 %3,608 / 4,300

63.4 %3,534 / 5,572

63.8 %3,555 / 5,571

57.7 %3,114 / 5,400

60.4 %3,345 / 5,539

61.1 %3,382 / 5,536

61.5 %3,474 / 5,651

60.1 %3,282 / 5,463

58.8 %3,227 / 5,486

61.9 %3,406 / 5,505

59.5 %3,324 / 5,589

59.1 %3,386 / 5,731

57.0 %3,203 / 5,623

58.7 %3,222 / 5,490

61.4 %3,385 / 5,513

59.7 %3,541 / 5,933

61.3 %3,088 / 5,037

60.4 %3,447 / 5,704

67.4 %3,408 / 5,054

79.3 %3,618 / 4,560

69.7 %3,476 / 4,988

64.7 %3,398 / 5,252

68.9 %3,469 / 5,034

74.7 %3,622 / 4,851

69.8 %3,582 / 5,129

63.7 %3,038 / 4,768

81.7 %3,538 / 4,330

66.8 %3,370 / 5,043

76.4 %3,622 / 4,739

64.6 %3,337 / 5,169

64.4 %3,356 / 5,212

73.7 %3,568 / 4,838

72.2 %3,574 / 4,950

74.8 %3,556 / 4,752

73.1 %3,598 / 4,919

63.4 %3,434 / 5,415

4.5 %207 / 4,602

66.0 %3,383 / 5,128

69.0 %3,510 / 5,084

59.6 %3,628 / 6,091

60.5 %3,654 / 6,037

57.4 %3,337 / 5,815

60.7 %3,596 / 5,920

61.8 %3,642 / 5,897

62.0 %3,724 / 6,008

59.9 %3,528 / 5,885

58.8 %3,461 / 5,885

62.0 %3,654 / 5,896

59.9 %3,574 / 5,962

59.7 %3,642 / 6,096

57.2 %3,436 / 6,012

58.7 %3,466 / 5,906

62.1 %3,652 / 5,877

60.9 %3,802 / 6,248

57.2 %3,110 / 5,439

60.6 %3,662 / 6,039

63.9 %3,558 / 5,564

67.4 %3,583 / 5,314

66.3 %3,627 / 5,473

62.0 %3,540 / 5,714

69.8 %3,695 / 5,291

65.2 %3,605 / 5,527

68.2 %3,794 / 5,562

58.4 %3,048 / 5,216

69.3 %3,496 / 5,045

64.0 %3,537 / 5,525

64.2 %3,521 / 5,482

61.1 %3,443 / 5,636

61.1 %3,466 / 5,669

65.3 %3,582 / 5,487

96.9 %4,465 / 4,610

65.4 %3,548 / 5,425

63.2 %3,548 / 5,612

63.2 %3,650 / 5,771

6.4 %242 / 3,797

92.2 %3,690 / 4,004

60.7 %3,396 / 5,599

61.1 %3,415 / 5,593

54.1 %2,956 / 5,463

56.7 %3,184 / 5,613

57.5 %3,222 / 5,606

57.7 %3,306 / 5,733

56.3 %3,123 / 5,544

55.2 %3,068 / 5,558

58.1 %3,245 / 5,587

56.0 %3,158 / 5,644

55.7 %3,229 / 5,795

54.3 %3,074 / 5,661

55.0 %3,065 / 5,572

57.6 %3,227 / 5,600

56.9 %3,394 / 5,965

61.6 %2,984 / 4,846

57.5 %3,289 / 5,720

64.2 %3,254 / 5,069

75.9 %3,467 / 4,565

66.6 %3,335 / 5,006

61.9 %3,257 / 5,258

66.3 %3,317 / 5,006

71.7 %3,479 / 4,855

67.2 %3,435 / 5,109

65.0 %2,947 / 4,536

79.5 %3,415 / 4,295

63.4 %3,210 / 5,062

73.6 %3,479 / 4,730

61.4 %3,194 / 5,200

61.4 %3,211 / 5,228

69.3 %3,381 / 4,879

68.0 %3,381 / 4,973

74.1 %3,469 / 4,681

69.3 %3,418 / 4,934

62.1 %3,325 / 5,353

4.3 %166 / 3,894

62.4 %3,499 / 5,604

62.9 %3,520 / 5,594

56.1 %3,063 / 5,458

58.8 %3,297 / 5,608

59.6 %3,338 / 5,596

59.8 %3,422 / 5,726

58.2 %3,232 / 5,554

57.4 %3,179 / 5,540

60.2 %3,360 / 5,585

58.0 %3,271 / 5,639

57.8 %3,342 / 5,786

56.2 %3,179 / 5,656

56.9 %3,173 / 5,572

59.8 %3,342 / 5,587

58.8 %3,504 / 5,963

62.9 %3,065 / 4,872

59.7 %3,398 / 5,692

67.1 %3,374 / 5,029

78.9 %3,582 / 4,541

69.6 %3,457 / 4,965

64.2 %3,362 / 5,235

69.0 %3,434 / 4,980

74.0 %3,586 / 4,845

69.9 %3,559 / 5,092

66.3 %3,027 / 4,563

82.9 %3,536 / 4,266

65.9 %3,320 / 5,038

76.7 %3,598 / 4,693

63.9 %3,302 / 5,167

63.8 %3,317 / 5,200

71.7 %3,485 / 4,860

71.2 %3,508 / 4,926

77.0 %3,586 / 4,655

71.6 %3,521 / 4,916

64.7 %3,443 / 5,321

6.5 %314 / 4,795

87.0 %4,480 / 5,147

70.6 %3,774 / 5,345

74.6 %4,032 / 5,406

75.3 %4,067 / 5,401

76.1 %4,163 / 5,474

73.3 %3,954 / 5,396

72.2 %3,895 / 5,398

75.2 %4,069 / 5,408

72.1 %3,981 / 5,524

72.1 %4,059 / 5,632

74.1 %4,000 / 5,396

71.1 %3,878 / 5,458

72.9 %4,020 / 5,512

81.0 %4,466 / 5,512

54.7 %3,154 / 5,763

52.4 %3,465 / 6,612

61.6 %3,541 / 5,753

63.2 %3,583 / 5,665

58.9 %3,491 / 5,926

58.7 %3,491 / 5,949

59.2 %3,513 / 5,933

63.6 %3,659 / 5,750

62.3 %3,710 / 5,954

55.8 %3,092 / 5,539

60.5 %3,409 / 5,639

60.0 %3,481 / 5,798

60.9 %3,545 / 5,821

84.2 %4,183 / 4,965

80.0 %4,093 / 5,119

65.3 %3,708 / 5,677

60.5 %3,605 / 5,956

59.2 %3,492 / 5,894

57.3 %3,471 / 6,059

54.2 %3,465 / 6,390

7.8 %372 / 4,765

71.4 %3,788 / 5,302

75.0 %4,037 / 5,383

76.1 %4,083 / 5,363

76.7 %4,173 / 5,444

74.0 %3,966 / 5,358

73.1 %3,912 / 5,353

76.1 %4,083 / 5,364

72.9 %3,996 / 5,484

72.6 %4,067 / 5,600

73.1 %3,955 / 5,410

71.7 %3,888 / 5,422

73.9 %4,039 / 5,462

80.4 %4,429 / 5,511

54.3 %3,169 / 5,836

53.1 %3,489 / 6,573

61.4 %3,548 / 5,775

63.8 %3,610 / 5,662

59.2 %3,508 / 5,924

58.8 %3,507 / 5,960

59.7 %3,540 / 5,925

64.0 %3,681 / 5,756

62.9 %3,740 / 5,945

55.0 %3,102 / 5,640

61.2 %3,432 / 5,609

60.5 %3,501 / 5,789

61.5 %3,564 / 5,795

83.7 %4,146 / 4,953

81.0 %4,106 / 5,071

66.3 %3,729 / 5,627

61.6 %3,635 / 5,900

59.7 %3,512 / 5,882

57.8 %3,498 / 6,053

54.9 %3,490 / 6,358

6.5 %275 / 4,255

85.8 %4,083 / 4,758

87.9 %4,148 / 4,719

87.3 %4,210 / 4,821

84.3 %4,000 / 4,745

83.2 %3,951 / 4,746

87.2 %4,129 / 4,735

83.0 %4,039 / 4,866

82.1 %4,091 / 4,983

76.5 %3,812 / 4,986

80.1 %3,883 / 4,849

80.9 %3,994 / 4,935

76.9 %4,082 / 5,311

48.8 %2,769 / 5,670

48.9 %3,123 / 6,387

55.2 %3,117 / 5,651

57.8 %3,168 / 5,483

54.4 %3,115 / 5,722

53.0 %3,084 / 5,821

54.1 %3,109 / 5,744

57.2 %3,219 / 5,627

56.4 %3,282 / 5,818

49.4 %2,697 / 5,463

56.7 %3,055 / 5,387

54.9 %3,093 / 5,638

54.9 %3,108 / 5,657

69.8 %3,524 / 5,052

70.1 %3,564 / 5,086

60.2 %3,304 / 5,491

58.3 %3,313 / 5,682

54.1 %3,087 / 5,708

52.8 %3,098 / 5,864

50.5 %3,112 / 6,159

6.5 %297 / 4,585

92.4 %4,420 / 4,782

93.1 %4,510 / 4,846

90.9 %4,321 / 4,752

89.3 %4,258 / 4,766

91.4 %4,391 / 4,802

86.7 %4,286 / 4,946

86.2 %4,354 / 5,052

82.5 %4,123 / 4,999

87.2 %4,217 / 4,835

86.4 %4,284 / 4,956

82.3 %4,384 / 5,324

50.5 %2,949 / 5,843

52.0 %3,369 / 6,481

58.1 %3,351 / 5,768

60.8 %3,408 / 5,604

57.4 %3,344 / 5,830

55.9 %3,316 / 5,935

57.0 %3,342 / 5,868

60.7 %3,469 / 5,718

59.2 %3,512 / 5,930

50.9 %2,875 / 5,643

58.0 %3,242 / 5,586

57.5 %3,317 / 5,768

58.0 %3,347 / 5,771

73.7 %3,780 / 5,130

73.6 %3,809 / 5,175

62.8 %3,533 / 5,624

61.7 %3,572 / 5,787

56.6 %3,311 / 5,848

55.9 %3,339 / 5,968

53.2 %3,345 / 6,285

6.5 %299 / 4,615

93.8 %4,543 / 4,844

90.6 %4,329 / 4,776

89.6 %4,280 / 4,777

92.6 %4,436 / 4,791

87.8 %4,330 / 4,934

87.4 %4,401 / 5,037

82.8 %4,146 / 5,009

86.4 %4,213 / 4,877

87.4 %4,324 / 4,949

83.2 %4,427 / 5,320

51.2 %2,989 / 5,836

52.5 %3,402 / 6,480

59.1 %3,394 / 5,744

61.6 %3,449 / 5,602

58.0 %3,382 / 5,829

56.6 %3,354 / 5,923

57.6 %3,378 / 5,868

61.4 %3,510 / 5,718

60.0 %3,556 / 5,925

51.8 %2,916 / 5,632

58.8 %3,280 / 5,578

58.4 %3,356 / 5,750

58.7 %3,387 / 5,767

74.4 %3,815 / 5,127

74.7 %3,853 / 5,159

63.6 %3,573 / 5,615

62.8 %3,618 / 5,764

57.2 %3,345 / 5,850

56.7 %3,382 / 5,960

53.9 %3,383 / 6,279

6.9 %329 / 4,769

90.2 %4,398 / 4,874

89.1 %4,343 / 4,876

93.4 %4,532 / 4,853

88.5 %4,432 / 5,009

88.3 %4,506 / 5,102

82.4 %4,209 / 5,105

86.2 %4,286 / 4,972

87.8 %4,414 / 5,029

84.4 %4,532 / 5,370

51.4 %3,067 / 5,966

52.8 %3,484 / 6,602

59.4 %3,476 / 5,850

61.7 %3,532 / 5,721

58.4 %3,467 / 5,936

57.0 %3,439 / 6,035

57.8 %3,462 / 5,991

61.8 %3,593 / 5,814

60.5 %3,642 / 6,024

51.8 %2,991 / 5,774

59.0 %3,365 / 5,707

58.6 %3,439 / 5,864

58.9 %3,470 / 5,892

74.7 %3,901 / 5,221

75.7 %3,963 / 5,232

64.0 %3,661 / 5,718

62.9 %3,699 / 5,877

57.4 %3,428 / 5,971

56.9 %3,464 / 6,093

54.1 %3,467 / 6,408

6.6 %296 / 4,483

92.3 %4,283 / 4,642

91.7 %4,353 / 4,745

87.1 %4,254 / 4,883

86.4 %4,318 / 5,000

84.2 %4,126 / 4,901

88.9 %4,216 / 4,742

86.6 %4,246 / 4,901

80.3 %4,290 / 5,341

49.8 %2,883 / 5,784

51.3 %3,294 / 6,424

57.4 %3,282 / 5,722

60.2 %3,340 / 5,544

56.7 %3,276 / 5,782

54.9 %3,242 / 5,901

56.4 %3,275 / 5,807

59.9 %3,400 / 5,674

58.5 %3,444 / 5,890

50.3 %2,810 / 5,581

57.6 %3,184 / 5,523

56.8 %3,247 / 5,715

57.5 %3,283 / 5,714

73.3 %3,727 / 5,084

73.3 %3,757 / 5,127

62.2 %3,468 / 5,578

61.1 %3,509 / 5,747

56.1 %3,247 / 5,789

55.4 %3,272 / 5,910

52.7 %3,279 / 6,221

6.5 %289 / 4,438

90.3 %4,293 / 4,754

86.1 %4,206 / 4,883

85.0 %4,257 / 5,007

83.4 %4,084 / 4,894

87.5 %4,158 / 4,753

84.8 %4,176 / 4,925

79.1 %4,230 / 5,350

48.9 %2,833 / 5,788

50.2 %3,240 / 6,455

56.4 %3,232 / 5,730

59.0 %3,286 / 5,566

55.5 %3,220 / 5,801

53.9 %3,187 / 5,912

55.3 %3,224 / 5,825

58.8 %3,346 / 5,686

57.3 %3,383 / 5,907

49.6 %2,766 / 5,578

56.6 %3,129 / 5,524

55.9 %3,199 / 5,721

56.4 %3,231 / 5,727

72.3 %3,674 / 5,081

72.2 %3,702 / 5,124

61.4 %3,420 / 5,569

59.9 %3,441 / 5,748

55.0 %3,191 / 5,798

54.3 %3,218 / 5,922

51.7 %3,226 / 6,237

6.5 %300 / 4,609

88.9 %4,360 / 4,903

88.8 %4,441 / 5,001

82.8 %4,146 / 5,007

86.8 %4,221 / 4,862

87.6 %4,336 / 4,951

82.7 %4,413 / 5,333

51.6 %3,004 / 5,824

52.9 %3,420 / 6,467

59.4 %3,403 / 5,731

62.3 %3,472 / 5,575

58.5 %3,402 / 5,811

56.9 %3,367 / 5,918

58.1 %3,402 / 5,852

61.4 %3,511 / 5,718

60.5 %3,573 / 5,910

52.2 %2,931 / 5,618

59.4 %3,305 / 5,564

58.8 %3,370 / 5,732

58.8 %3,393 / 5,769

74.7 %3,824 / 5,118

75.1 %3,864 / 5,147

64.2 %3,586 / 5,587

63.1 %3,635 / 5,758

57.7 %3,367 / 5,834

57.1 %3,396 / 5,948

54.4 %3,403 / 6,261

6.6 %304 / 4,640

90.6 %4,482 / 4,947

80.7 %4,103 / 5,084

84.7 %4,182 / 4,938

83.4 %4,237 / 5,083

79.0 %4,320 / 5,466

48.8 %2,927 / 5,994

51.1 %3,340 / 6,537

56.9 %3,320 / 5,838

59.8 %3,382 / 5,656

56.1 %3,315 / 5,904

54.4 %3,282 / 6,038

56.0 %3,322 / 5,937

58.7 %3,423 / 5,834

58.2 %3,492 / 5,998

49.5 %2,860 / 5,774

57.3 %3,219 / 5,621

56.3 %3,286 / 5,832

56.6 %3,310 / 5,844

71.4 %3,736 / 5,233

72.6 %3,800 / 5,231

61.4 %3,497 / 5,698

60.9 %3,552 / 5,828

55.8 %3,286 / 5,893

55.1 %3,315 / 6,017

52.7 %3,329 / 6,321

8.1 %389 / 4,774

79.3 %4,143 / 5,222

82.6 %4,205 / 5,092

83.3 %4,315 / 5,181

78.8 %4,386 / 5,567

49.7 %2,992 / 6,023

51.2 %3,415 / 6,674

56.4 %3,385 / 6,004

59.4 %3,450 / 5,808

55.7 %3,379 / 6,061

54.7 %3,364 / 6,152

55.8 %3,390 / 6,077

58.6 %3,493 / 5,958

58.4 %3,570 / 6,108

50.1 %2,922 / 5,832

57.1 %3,288 / 5,763

55.9 %3,350 / 5,994

56.2 %3,371 / 5,996

71.0 %3,804 / 5,355

72.5 %3,876 / 5,343

61.0 %3,561 / 5,842

60.5 %3,616 / 5,981

55.5 %3,351 / 6,036

54.8 %3,380 / 6,171

52.7 %3,402 / 6,461

7.1 %319 / 4,516

84.8 %4,128 / 4,867

80.4 %4,112 / 5,115

84.0 %4,405 / 5,246

48.3 %2,838 / 5,881

49.2 %3,232 / 6,565

54.8 %3,216 / 5,873

57.5 %3,272 / 5,695

53.5 %3,188 / 5,963

53.2 %3,188 / 5,988

54.4 %3,225 / 5,932

57.2 %3,333 / 5,824

56.1 %3,383 / 6,028

48.6 %2,762 / 5,683

55.0 %3,114 / 5,660

54.3 %3,187 / 5,864

55.1 %3,226 / 5,850

73.5 %3,759 / 5,115

70.4 %3,694 / 5,244

59.2 %3,379 / 5,708

58.1 %3,416 / 5,875

53.8 %3,188 / 5,921

53.1 %3,211 / 6,045

50.9 %3,230 / 6,348

6.4 %286 / 4,461

83.6 %4,156 / 4,971

79.4 %4,249 / 5,349

48.5 %2,829 / 5,829

50.3 %3,247 / 6,451

55.9 %3,221 / 5,759

58.8 %3,276 / 5,569

55.2 %3,213 / 5,816

53.7 %3,188 / 5,932

55.3 %3,223 / 5,828

58.4 %3,335 / 5,707

57.2 %3,383 / 5,918

49.0 %2,758 / 5,625

56.2 %3,121 / 5,550

55.5 %3,190 / 5,746

56.2 %3,225 / 5,743

71.5 %3,664 / 5,124

72.5 %3,717 / 5,126

60.8 %3,403 / 5,599

59.7 %3,446 / 5,768

54.6 %3,182 / 5,824

54.3 %3,216 / 5,926

51.9 %3,231 / 6,231

6.8 %317 / 4,648

79.7 %4,358 / 5,467

51.5 %2,993 / 5,815

52.5 %3,408 / 6,495

59.3 %3,413 / 5,760

61.2 %3,443 / 5,628

58.1 %3,398 / 5,844

56.0 %3,340 / 5,963

57.9 %3,394 / 5,866

61.5 %3,523 / 5,724

60.1 %3,574 / 5,944

51.8 %2,917 / 5,634

58.9 %3,284 / 5,574

58.6 %3,376 / 5,758

60.1 %3,431 / 5,707

72.3 %3,777 / 5,221

72.2 %3,799 / 5,260

63.6 %3,573 / 5,615

63.2 %3,629 / 5,743

57.3 %3,352 / 5,850

57.2 %3,399 / 5,942

53.8 %3,387 / 6,290

7.1 %360 / 5,105

51.6 %3,150 / 6,107

51.7 %3,553 / 6,874

56.9 %3,518 / 6,184

60.1 %3,607 / 6,001

56.0 %3,510 / 6,268

56.2 %3,511 / 6,247

57.0 %3,552 / 6,236

60.2 %3,670 / 6,100

59.2 %3,730 / 6,299

51.6 %3,058 / 5,925

57.5 %3,429 / 5,968

56.5 %3,490 / 6,176

57.9 %3,562 / 6,151

78.8 %4,169 / 5,288

75.9 %4,112 / 5,417

62.4 %3,729 / 5,980

61.7 %3,775 / 6,118

56.6 %3,520 / 6,218

55.8 %3,542 / 6,350

53.1 %3,543 / 6,670

5.1 %188 / 3,667

51.1 %3,044 / 5,957

54.1 %3,022 / 5,587

58.1 %3,107 / 5,347

56.1 %3,027 / 5,398

54.6 %3,014 / 5,522

59.4 %3,045 / 5,125

59.5 %3,137 / 5,270

58.9 %3,158 / 5,363

84.3 %3,284 / 3,896

62.0 %3,017 / 4,864

54.5 %3,006 / 5,516

58.8 %3,075 / 5,231

54.9 %2,969 / 5,412

54.9 %2,979 / 5,422

57.2 %3,076 / 5,378

58.6 %3,101 / 5,296

56.2 %3,061 / 5,445

56.7 %3,096 / 5,457

54.6 %3,041 / 5,572

5.3 %261 / 4,953

60.7 %3,579 / 5,892

58.6 %3,444 / 5,876

70.3 %3,877 / 5,516

63.7 %3,738 / 5,870

61.6 %3,562 / 5,785

59.1 %3,537 / 5,983

59.3 %3,614 / 6,093

51.9 %2,984 / 5,755

60.2 %3,384 / 5,624

60.9 %3,560 / 5,846

58.9 %3,472 / 5,897

53.0 %3,281 / 6,191

53.0 %3,301 / 6,231

55.9 %3,399 / 6,081

62.1 %3,660 / 5,892

57.2 %3,417 / 5,972

54.8 %3,399 / 6,199

84.8 %4,469 / 5,272

5.0 %218 / 4,327

66.4 %3,437 / 5,176

69.3 %3,613 / 5,210

65.0 %3,548 / 5,458

64.3 %3,449 / 5,364

64.2 %3,476 / 5,418

62.9 %3,521 / 5,599

55.8 %2,981 / 5,342

66.3 %3,324 / 5,013

90.5 %4,101 / 4,529

64.4 %3,440 / 5,345

61.3 %3,320 / 5,415

60.9 %3,330 / 5,467

66.8 %3,514 / 5,264

64.5 %3,512 / 5,446

63.7 %3,397 / 5,331

59.9 %3,350 / 5,593

63.4 %3,574 / 5,635

4.0 %165 / 4,143

68.8 %3,521 / 5,119

64.0 %3,453 / 5,399

68.2 %3,516 / 5,157

79.5 %3,829 / 4,816

71.2 %3,690 / 5,180

60.6 %3,062 / 5,055

76.9 %3,505 / 4,558

66.0 %3,404 / 5,157

73.2 %3,615 / 4,941

64.6 %3,387 / 5,240

64.3 %3,402 / 5,288

74.7 %3,658 / 4,895

69.6 %3,583 / 5,148

72.8 %3,563 / 4,893

71.3 %3,605 / 5,058

62.4 %3,471 / 5,559

5.1 %221 / 4,371

73.9 %3,806 / 5,150

70.1 %3,607 / 5,145

69.3 %3,629 / 5,233

68.9 %3,702 / 5,371

58.1 %2,988 / 5,139

69.7 %3,435 / 4,926

68.9 %3,580 / 5,195

67.5 %3,517 / 5,207

59.9 %3,308 / 5,518

59.9 %3,325 / 5,554

65.2 %3,477 / 5,336

68.1 %3,626 / 5,321

66.0 %3,478 / 5,267

62.5 %3,447 / 5,517

71.4 %3,828 / 5,360

6.0 %268 / 4,451

64.9 %3,515 / 5,412

65.7 %3,574 / 5,444

63.9 %3,601 / 5,632

56.5 %2,973 / 5,261

64.7 %3,352 / 5,182

64.7 %3,521 / 5,438

62.0 %3,427 / 5,525

58.5 %3,289 / 5,625

58.0 %3,298 / 5,687

61.8 %3,434 / 5,555

63.6 %3,538 / 5,561

61.2 %3,394 / 5,549

57.6 %3,350 / 5,811

64.8 %3,686 / 5,687

5.6 %236 / 4,244

67.7 %3,578 / 5,285

68.9 %3,677 / 5,337

61.0 %2,994 / 4,905

69.7 %3,424 / 4,912

64.7 %3,433 / 5,308

67.6 %3,519 / 5,205

61.0 %3,341 / 5,479

60.7 %3,356 / 5,526

64.6 %3,484 / 5,390

71.7 %3,693 / 5,152

66.8 %3,500 / 5,241

62.4 %3,415 / 5,472

64.1 %3,552 / 5,544

5.3 %230 / 4,376

69.9 %3,734 / 5,345

60.9 %3,077 / 5,051

71.3 %3,490 / 4,896

63.5 %3,435 / 5,412

71.5 %3,666 / 5,130

64.0 %3,448 / 5,389

64.0 %3,467 / 5,420

71.0 %3,683 / 5,190

67.1 %3,604 / 5,370

69.9 %3,617 / 5,178

66.5 %3,589 / 5,395

62.6 %3,555 / 5,675

5.0 %233 / 4,632

59.7 %3,081 / 5,164

68.1 %3,491 / 5,124

62.6 %3,490 / 5,571

66.8 %3,602 / 5,393

63.0 %3,508 / 5,571

62.8 %3,526 / 5,611

65.0 %3,582 / 5,511

68.1 %3,733 / 5,483

67.3 %3,625 / 5,383

61.8 %3,515 / 5,688

62.5 %3,636 / 5,813

4.0 %138 / 3,456

64.5 %2,971 / 4,604

55.5 %2,945 / 5,304

59.9 %3,016 / 5,032

55.5 %2,893 / 5,215

55.5 %2,904 / 5,230

58.4 %3,008 / 5,147

60.2 %3,047 / 5,065

58.2 %3,005 / 5,166

57.4 %3,041 / 5,298

56.1 %2,996 / 5,336

4.3 %165 / 3,851

68.7 %3,364 / 4,900

77.1 %3,582 / 4,648

64.6 %3,288 / 5,088

64.3 %3,300 / 5,132

73.5 %3,505 / 4,769

71.5 %3,495 / 4,886

78.1 %3,576 / 4,581

70.2 %3,462 / 4,932

64.6 %3,415 / 5,283

4.9 %211 / 4,271

66.6 %3,481 / 5,229

63.3 %3,354 / 5,302

62.9 %3,366 / 5,354

68.8 %3,549 / 5,155

64.6 %3,492 / 5,407

66.0 %3,442 / 5,219

59.9 %3,330 / 5,557

63.8 %3,556 / 5,574

5.7 %243 / 4,240

64.4 %3,419 / 5,309

64.4 %3,438 / 5,336

72.1 %3,650 / 5,061

66.1 %3,521 / 5,323

75.5 %3,719 / 4,929

68.6 %3,593 / 5,240

62.3 %3,502 / 5,625

5.9 %253 / 4,264

91.8 %4,114 / 4,480

69.1 %3,576 / 5,175

62.3 %3,426 / 5,495

63.0 %3,371 / 5,349

58.6 %3,297 / 5,625

55.1 %3,282 / 5,957

6.1 %263 / 4,322

69.7 %3,616 / 5,188

62.4 %3,449 / 5,530

62.8 %3,388 / 5,393

58.7 %3,317 / 5,653

55.1 %3,299 / 5,991

4.2 %183 / 4,350

66.5 %3,557 / 5,349

72.1 %3,625 / 5,025

65.6 %3,517 / 5,360

59.0 %3,411 / 5,784

4.4 %198 / 4,465

66.3 %3,514 / 5,302

64.9 %3,541 / 5,459

64.9 %3,649 / 5,620

3.7 %156 / 4,271

66.5 %3,514 / 5,281

61.4 %3,464 / 5,645

4.5 %201 / 4,458

58.0 %3,422 / 5,900

4.6 %216 / 4,733







Escherichia coli HS














Shigella boydii

CDC 3083-94












Escherichia coli

K12 W3110




Escherichia coli A

PECO1




Escherichia coli A

TCC8739


Escherichia coli SM

S3-3-5


Escherichia coli

K12 DH

10B


Escherichia coli

K12 MG

1655


Escherichia coli

0157:H7 str. Sakai


Escherichia coli

0157:H str. ED

L933


Escherichia coli

0157:H str. EC4045


Escherichia coli

0157:H str. EC4206


Escherichia coli

0157:H str. EC4042


Escherichia coli

0157:H str. EC4115


Escherichia coli

0157:H str. EC4196


Escherichia coli

0157:H str. EC4113


Escherichia coli

0157:H str. EC4076


Escherichia coli

0157:H str. EC4401


Escherichia coli

0157:H str. EC4486


Escherichia coli

0157:H str. EC4501


Escherichia coli

0157:H str. EC508


Escherichia coli

0157:H str. EC869


Escherichia coli

0157:H TW

14588






Escherichia coli

0127:H6 str. E2348/69












Escherichia coli U

MN

026


Shigella flexneri

2a str. 2457T







10407


Escherichia coli

LAN

L ECA


Escherichia coli

LAN

L ECF


Escherichia coli O

103 Oslo


Escherichia coli

SECEC SMS35




Escherichia coli

DSM

172521


Escherichia coli

Nissle 1917


Shige

lla d

ysen

teriae

Sd19

7

4,50

5 pro

tein

s, 3,

374

fam

ilies

Shige

lla bo

ydii

Sb22

7

4,28

4 pro

tein

s, 3,

474

fam

ilies

Shige

lla so

nnei

Ss0

46

4,47

5 pro

tein

s, 3,

730

fam

ilies

Esche

richi

a coli

HS

4,38

4 pro

tein

s, 4,

125

fam

ilies

Esche

richi

a coli

E24

377A

4,99

7 pro

tein

s, 4,

611

fam

ilies

Esche

richi

a coli

B7A

4,64

8 pro

tein

s, 4,

340

fam

ilies

Esche

richi

a coli

F11

4,70

4 pro

tein

s, 4,

393

fam

ilies

Esche

richi

a coli

E22

5,10

5 pro

tein

s, 4,

684

fam

ilies

Esche

richi

a coli

E11

0019

4,93

4 pro

tein

s, 4,

419

fam

ilies

Esche

richi

a coli

B17

1

5,01

0 pro

tein

s, 4,

482

fam

ilies

Shige

lla bo

ydii

CD

C 308

3-94

4,55

7 pro

tein

s, 3,

700

fam

ilies

Esche

richi

a coli

536

38

5,17

2 pro

tein

s, 4,

610

fam

ilies

Esche

richi

a coli

101

-1

4,60

7 pro

tein

s, 4,

299

fam

ilies

Shige

lla d

ysen

teriae

101

2

4,41

9 pro

tein

s, 3,

895

fam

ilies

Esche

richi

a coli

536

4,62

9 pro

tein

s, 4,

335

fam

ilies

Esche

richi

a coli

UTI8

9

5,21

1 pro

tein

s, 4,

894

fam

ilies

Esche

richi

a coli

K12

W31

10

4,22

6 pro

tein

s, 3,

965

fam

ilies

Shige

lla fl

exner

i

5 st

r. 84

01

4,11

6 pro

tein

s, 3,

502

fam

ilies

Esche

richi

a coli

APECO

1

4,89

0 pro

tein

s, 4,

559

fam

ilies

Esche

richi

a coli

SE11

5,00

2 pro

tein

s, 4,

663

fam

ilies

Esche

richi

a coli

ATCC87

39

4,20

0 pro

tein

s, 3,

977

fam

ilies

Esche

richi

a coli

SM

S3-3

-5

4,91

3 pro

tein

s, 4,

602

fam

ilies

Esche

richi

a coli

K12

DH

10B

4,12

6 pro

tein

s, 3,

797

fam

ilies

Esche

richi

a coli

K12

MG

1655

4,13

1 pro

tein

s, 3,

894

fam

ilies

Esche

richi

a coli

015

7:H

7 st

r. Sa

kai

5,44

7 pro

tein

s, 4,

795

fam

ilies

Esche

richi

a coli

015

7:H

str.

EDL93

3

5,44

9 pro

tein

s, 4,

765

fam

ilies

Esche

richi

a coli

015

7:H

str.

EC4045

4,78

1 pro

tein

s, 4,

255

fam

ilies

Esche

richi

a coli

015

7:H

str.

EC4206

5,20

2 pro

tein

s, 4,

585

fam

ilies

Esche

richi

a coli

015

7:H

str.

EC4042

5,23

2 pro

tein

s, 4,

615

fam

ilies

Esche

richi

a coli

015

7:H

str.

EC4115

5,47

7 pro

tein

s, 4,

769

fam

ilies

Esche

richi

a coli

015

7:H

str.

EC4196

5,07

2 pro

tein

s, 4,

483

fam

ilies

Esche

richi

a coli

015

7:H

str.

EC4113

5,00

5 pro

tein

s, 4,

438

fam

ilies

Esche

richi

a coli

015

7:H

str.

EC4076

5,24

2 pro

tein

s, 4,

609

fam

ilies

Esche

richi

a coli

015

7:H

str.

EC4401

5,18

5 pro

tein

s, 4,

640

fam

ilies

Esche

richi

a coli

015

7:H

str.

EC4486

5,42

9 pro

tein

s, 4,

774

fam

ilies

Esche

richi

a coli

015

7:H

str.

EC4501

5,12

4 pro

tein

s, 4,

516

fam

ilies

Esche

richi

a coli

015

7:H

str.

EC508

5,01

9 pro

tein

s, 4,

461

fam

ilies

Esche

richi

a coli

015

7:H

str.

EC869

5,22

0 pro

tein

s, 4,

648

fam

ilies

Esche

richi

a coli

015

7:H

TW

1458

8

5,80

3 pro

tein

s, 5,

105

fam

ilies

Shige

lla fl

exner

i

2a

str.

301

4,44

5 pro

tein

s, 3,

667

fam

ilies

Esche

richi

a coli

CFT07

3

5,37

9 pro

tein

s, 4,

953

fam

ilies

Esche

richi

a coli

012

7:H

6 st

r. E23

48/69

4,65

3 pro

tein

s, 4,

327

fam

ilies

Esche

richi

a coli

IAI1

4,35

4 pro

tein

s, 4,

143

fam

ilies

Esche

richi

a coli

S88

4,69

6 pro

tein

s, 4,

371

fam

ilies

Esche

richi

a coli

ED

1a

4,91

5 pro

tein

s, 4,

451

fam

ilies

Esche

richi

a coli

IAI3

9

4,73

2 pro

tein

s, 4,

244

fam

ilies

Esche

richi

a coli

559

89

4,76

3 pro

tein

s, 4,

376

fam

ilies

Esche

richi

a coli

UM

N02

6

4,96

8 pro

tein

s, 4,

632

fam

ilies

Shige

lla fl

exner

i

2a

str.

2457

T

4,06

8 pro

tein

s, 3,

456

fam

ilies

Esche

richi

a coli

B03

4,07

6 pro

tein

s, 3,

851

fam

ilies

Esche

richi

a coli

E23

48

4,59

2 pro

tein

s, 4,

271

fam

ilies

Esche

richi

a coli

EcH

1040

7

4,61

2 pro

tein

s, 4,

240

fam

ilies

Esche

richi

a coli

LA

NL E

CA

4,75

0 pro

tein

s, 4,

264

fam

ilies

Esche

richi

a coli

LA

NL E

CF

4,81

3 pro

tein

s, 4,

322

fam

ilies

Esche

richi

a coli

O10

3 O

slo

4,57

1 pro

tein

s, 4,

350

fam

ilies

Esche

richi

a coli

SECEC S

MS3

5

4,74

3 pro

tein

s, 4,

465

fam

ilies

Esche

richi

a coli

VR50

4,45

3 pro

tein

s, 4,

271

fam

ilies

Esche

richi

a coli

DSM

1725

21

4,71

1 pro

tein

s, 4,

458

fam

ilies

Esche

richi

a coli

Niss

le 1

917

5,05

3 pro

tein

s, 4,

733

fam

ilies


8.1 %3.3 %


96.9 %40.9 %

60 E. coli genomes[June, 2009]

www.cbs.dtu.dk/services/GenomeAtlas/ 87 projects found

as of 5 August, 2009

0.0 %0 / 182

2.3 %12 / 532

2.0 %15 / 733

0.0 %0 / 765

1.5 %12 / 780

2.3 %18 / 781

0.5 %12 / 2,316

0.4 %11 / 2,684

0.0 %0 / 3,804

0.2 %11 / 4,639

0.0 %0 / 3,844

0.3 %11 / 3,949

0.3 %12 / 4,136

0.3 %11 / 4,331

0.2 %11 / 4,489

0.3 %11 / 4,201

0.3 %11 / 4,206

0.2 %11 / 4,528

0.3 %11 / 4,213

0.2 %10 / 4,228

0.0 %0 / 4,622

0.2 %11 / 4,450

0.2 %11 / 4,723

0.2 %11 / 4,637

0.2 %10 / 4,670

0.3 %11 / 4,248

0.2 %10 / 5,644

0.2 %11 / 4,486

0.3 %11 / 4,259

0.2 %10 / 5,759

0.2 %11 / 4,404

0.2 %10 / 4,587

0.2 %11 / 4,413

0.2 %11 / 4,583

0.2 %11 / 5,106

0.0 %0 / 5,174

0.2 %10 / 5,935

0.2 %10 / 5,199

0.0 %0 / 362

32.8 %229 / 699

0.0 %0 / 945

18.0 %148 / 824

17.0 %142 / 837

6.2 %147 / 2,360

5.7 %154 / 2,719

0.0 %0 / 3,984

3.4 %160 / 4,667

4.2 %161 / 3,856

3.9 %154 / 3,986

3.9 %163 / 4,162

3.7 %160 / 4,361

3.5 %159 / 4,519

3.8 %162 / 4,228

3.6 %154 / 4,241

3.5 %161 / 4,556

3.8 %162 / 4,239

3.8 %161 / 4,254

0.0 %0 / 4,802

3.6 %162 / 4,478

3.4 %162 / 4,749

3.5 %164 / 4,661

3.4 %162 / 4,697

3.8 %164 / 4,272

2.9 %163 / 5,667

3.6 %162 / 4,511

3.9 %167 / 4,280

2.8 %164 / 5,781

3.6 %158 / 4,433

3.6 %165 / 4,608

3.6 %161 / 4,440

3.6 %168 / 4,604

3.1 %161 / 5,130

0.0 %0 / 5,354

2.7 %161 / 5,957

3.1 %161 / 5,224

0.4 %2 / 565

27.4 %247 / 901

29.4 %267 / 908

22.6 %218 / 965

12.6 %304 / 2,405

13.1 %356 / 2,717

10.4 %394 / 3,782

8.2 %382 / 4,642

9.6 %371 / 3,846

8.8 %350 / 3,989

9.2 %383 / 4,141

8.9 %385 / 4,336

8.5 %383 / 4,492

9.2 %386 / 4,202

8.8 %370 / 4,222

8.5 %385 / 4,530

9.4 %394 / 4,204

9.2 %387 / 4,229

8.3 %384 / 4,610

8.7 %388 / 4,453

8.1 %383 / 4,729

8.4 %390 / 4,634

8.1 %381 / 4,679

9.3 %395 / 4,239

7.0 %392 / 5,637

8.9 %397 / 4,474

9.2 %390 / 4,256

6.7 %385 / 5,758

8.8 %387 / 4,403

8.3 %381 / 4,590

8.7 %383 / 4,417

8.4 %387 / 4,585

7.6 %386 / 5,101

7.3 %377 / 5,165

6.3 %374 / 5,941

7.3 %381 / 5,201

0.0 %0 / 583

84.7 %547 / 646

21.1 %209 / 991

11.6 %284 / 2,444

15.4 %414 / 2,681

9.5 %365 / 3,832

8.2 %381 / 4,665

9.4 %363 / 3,872

8.8 %351 / 4,010

9.1 %381 / 4,166

8.6 %377 / 4,365

8.6 %388 / 4,510

9.3 %391 / 4,219

8.8 %372 / 4,240

8.6 %389 / 4,548

9.2 %390 / 4,227

8.6 %369 / 4,267

7.9 %365 / 4,649

8.3 %373 / 4,486

7.8 %370 / 4,761

8.1 %376 / 4,668

7.9 %370 / 4,709

8.8 %375 / 4,281

6.7 %378 / 5,671

8.2 %372 / 4,517

8.7 %373 / 4,294

6.3 %368 / 5,796

8.4 %374 / 4,437

7.9 %366 / 4,626

8.7 %386 / 4,433

8.2 %377 / 4,617

7.6 %388 / 5,119

7.3 %376 / 5,185

6.2 %371 / 5,963

7.3 %379 / 5,225

0.0 %0 / 610

24.2 %239 / 988

14.1 %341 / 2,413

19.3 %504 / 2,618

12.0 %454 / 3,768

10.1 %464 / 4,607

11.6 %442 / 3,821

10.8 %427 / 3,957

11.1 %455 / 4,117

10.7 %461 / 4,305

10.5 %468 / 4,454

11.3 %469 / 4,166

10.7 %450 / 4,189

10.4 %467 / 4,496

11.4 %475 / 4,165

10.8 %455 / 4,206

9.8 %449 / 4,589

10.3 %455 / 4,430

9.7 %454 / 4,703

9.9 %456 / 4,614

9.7 %450 / 4,654

10.8 %456 / 4,225

8.2 %459 / 5,615

10.2 %456 / 4,461

10.7 %453 / 4,239

7.8 %449 / 5,739

10.5 %459 / 4,378

9.8 %446 / 4,572

10.6 %465 / 4,381

9.9 %451 / 4,570

9.3 %471 / 5,059

9.0 %463 / 5,123

7.7 %457 / 5,900

8.8 %453 / 5,173

0.0 %0 / 617

10.5 %262 / 2,496

11.2 %314 / 2,810

7.4 %293 / 3,934

6.3 %301 / 4,776

7.2 %288 / 3,981

6.3 %259 / 4,131

6.7 %289 / 4,290

6.5 %293 / 4,479

6.5 %301 / 4,627

7.0 %303 / 4,339

6.7 %290 / 4,358

6.4 %300 / 4,670

6.9 %301 / 4,352

6.6 %290 / 4,379

6.1 %291 / 4,755

6.4 %295 / 4,597

5.9 %288 / 4,873

6.2 %297 / 4,780

6.0 %290 / 4,818

6.9 %302 / 4,385

5.2 %303 / 5,778

6.6 %303 / 4,622

6.7 %295 / 4,403

5.0 %293 / 5,902

6.6 %302 / 4,542

5.9 %280 / 4,747

6.6 %302 / 4,552

6.2 %295 / 4,732

5.6 %295 / 5,248

5.3 %283 / 5,313

4.7 %283 / 6,086

5.6 %298 / 5,335

6.6 %124 / 1,886

21.8 %819 / 3,757

16.7 %819 / 4,911

14.9 %851 / 5,716

16.0 %797 / 4,976

15.5 %792 / 5,100

15.4 %812 / 5,261

15.2 %828 / 5,433

16.6 %911 / 5,495

17.4 %909 / 5,214

16.7 %879 / 5,256

16.3 %903 / 5,554

17.6 %917 / 5,207

14.9 %798 / 5,352

14.0 %802 / 5,716

14.6 %807 / 5,538

13.8 %807 / 5,848

14.2 %814 / 5,746

14.1 %812 / 5,777

15.1 %811 / 5,370

12.2 %824 / 6,738

14.8 %825 / 5,580

15.3 %822 / 5,370

12.1 %827 / 6,853

15.0 %827 / 5,509

13.9 %796 / 5,721

15.3 %844 / 5,499

14.8 %841 / 5,679

14.4 %880 / 6,130

13.0 %816 / 6,266

11.8 %826 / 7,010

12.9 %812 / 6,310

4.7 %110 / 2,318

31.2 %1,439 / 4,609

27.4 %1,476 / 5,392

26.0 %1,260 / 4,846

27.0 %1,318 / 4,887

28.3 %1,410 / 4,975

28.1 %1,444 / 5,130

27.2 %1,442 / 5,311

29.1 %1,457 / 5,001

26.8 %1,371 / 5,109

26.9 %1,436 / 5,340

29.4 %1,464 / 4,979

27.7 %1,401 / 5,057

25.8 %1,398 / 5,418

26.5 %1,393 / 5,254

24.7 %1,376 / 5,572

26.1 %1,420 / 5,447

24.6 %1,368 / 5,556

28.3 %1,430 / 5,061

22.8 %1,449 / 6,362

27.3 %1,437 / 5,255

28.6 %1,446 / 5,053

22.6 %1,474 / 6,511

28.4 %1,470 / 5,180

26.6 %1,436 / 5,401

28.3 %1,465 / 5,184

23.9 %1,316 / 5,513

26.0 %1,513 / 5,809

24.4 %1,447 / 5,921

21.8 %1,453 / 6,664

23.9 %1,436 / 5,997

2.4 %85 / 3,515

34.7 %2,038 / 5,878

28.7 %1,601 / 5,585

29.6 %1,664 / 5,625

34.7 %1,909 / 5,505

35.3 %1,985 / 5,622

33.6 %1,966 / 5,855

35.5 %1,970 / 5,551

32.2 %1,840 / 5,707

32.4 %1,926 / 5,939

37.2 %2,038 / 5,477

33.2 %1,872 / 5,645

31.4 %1,884 / 5,996

32.8 %1,914 / 5,843

31.1 %1,897 / 6,095

32.4 %1,942 / 6,001

30.2 %1,855 / 6,133

35.6 %1,980 / 5,555

29.4 %2,025 / 6,899

33.9 %1,971 / 5,810

35.9 %1,993 / 5,558

28.2 %1,989 / 7,051

39.4 %2,167 / 5,502

36.5 %2,103 / 5,761

36.2 %2,039 / 5,631

26.2 %1,648 / 6,288

37.0 %2,245 / 6,069

34.8 %2,172 / 6,237

30.9 %2,163 / 6,992

32.6 %2,080 / 6,390

3.7 %155 / 4,227

28.5 %1,776 / 6,228

29.1 %1,829 / 6,275

44.4 %2,494 / 5,618

48.3 %2,697 / 5,584

34.8 %2,216 / 6,370

36.4 %2,215 / 6,090

33.4 %2,062 / 6,180

34.1 %2,179 / 6,395

38.8 %2,315 / 5,965

31.9 %2,015 / 6,308

30.4 %2,028 / 6,667

31.4 %2,040 / 6,491

29.6 %2,012 / 6,805

31.6 %2,093 / 6,623

28.9 %1,976 / 6,833

34.4 %2,123 / 6,179

28.7 %2,163 / 7,529

33.8 %2,161 / 6,398

33.2 %2,079 / 6,263

27.7 %2,130 / 7,691

38.5 %2,342 / 6,078

33.9 %2,188 / 6,454

66.5 %3,329 / 5,008

25.3 %1,754 / 6,945

36.4 %2,425 / 6,659

33.6 %2,304 / 6,866

31.3 %2,362 / 7,545

32.9 %2,284 / 6,943

2.4 %85 / 3,522

30.1 %1,694 / 5,619

28.8 %1,675 / 5,823

28.0 %1,681 / 6,008

30.4 %1,838 / 6,039

31.9 %1,831 / 5,748

29.3 %1,726 / 5,881

29.8 %1,818 / 6,100

33.6 %1,907 / 5,677

28.8 %1,697 / 5,884

27.5 %1,710 / 6,227

27.9 %1,706 / 6,111

26.6 %1,688 / 6,354

27.9 %1,743 / 6,238

26.4 %1,676 / 6,344

30.6 %1,779 / 5,809

25.7 %1,831 / 7,111

29.8 %1,793 / 6,020

30.8 %1,787 / 5,802

25.0 %1,817 / 7,282

30.0 %1,790 / 5,970

26.9 %1,688 / 6,275

28.9 %1,742 / 6,032

29.9 %1,834 / 6,129

29.7 %1,922 / 6,470

26.5 %1,781 / 6,719

24.1 %1,796 / 7,455

26.7 %1,794 / 6,727

2.8 %101 / 3,556

30.1 %1,755 / 5,834

29.4 %1,764 / 5,994

31.7 %1,910 / 6,027

33.4 %1,913 / 5,726

30.4 %1,777 / 5,851

31.0 %1,878 / 6,064

34.3 %1,953 / 5,693

32.0 %1,860 / 5,806

30.9 %1,867 / 6,049

31.1 %1,863 / 5,998

29.1 %1,829 / 6,289

31.2 %1,915 / 6,137

30.7 %1,797 / 5,846

33.9 %1,946 / 5,744

28.3 %1,988 / 7,025

31.9 %1,917 / 6,017

34.0 %1,954 / 5,744

27.8 %1,995 / 7,182

31.0 %1,863 / 6,006

28.8 %1,801 / 6,261

29.8 %1,805 / 6,066

25.0 %1,620 / 6,482

31.4 %2,028 / 6,455

28.4 %1,901 / 6,689

25.4 %1,894 / 7,444

29.3 %1,956 / 6,684

3.1 %118 / 3,785

56.8 %2,820 / 4,964

33.3 %2,026 / 6,079

35.2 %2,031 / 5,776

32.2 %1,907 / 5,924

32.5 %2,001 / 6,153

37.3 %2,117 / 5,678

32.5 %1,911 / 5,875

31.0 %1,927 / 6,219

32.0 %1,946 / 6,081

29.9 %1,908 / 6,373

31.8 %1,969 / 6,191

29.5 %1,886 / 6,394

35.0 %2,023 / 5,787

28.5 %2,037 / 7,146

33.1 %2,006 / 6,066

34.0 %1,989 / 5,858

27.4 %2,004 / 7,317

37.4 %2,162 / 5,781

34.0 %2,072 / 6,094

46.9 %2,515 / 5,357

25.1 %1,649 / 6,577

35.4 %2,261 / 6,380

33.7 %2,191 / 6,492

31.3 %2,244 / 7,165

31.4 %2,086 / 6,647

3.7 %146 / 3,904

33.9 %2,099 / 6,190

35.7 %2,102 / 5,885

32.4 %1,955 / 6,034

33.0 %2,063 / 6,244

36.8 %2,147 / 5,842

32.0 %1,944 / 6,080

30.3 %1,948 / 6,431

31.3 %1,970 / 6,296

29.4 %1,937 / 6,591

31.3 %2,006 / 6,406

30.3 %1,908 / 6,300

34.3 %2,049 / 5,973

28.5 %2,084 / 7,313

32.7 %2,041 / 6,233

33.0 %2,002 / 6,063

26.9 %2,025 / 7,517

37.8 %2,234 / 5,903

34.0 %2,124 / 6,250

49.4 %2,665 / 5,394

25.7 %1,710 / 6,664

35.5 %2,310 / 6,501

34.2 %2,269 / 6,636

31.3 %2,294 / 7,331

31.4 %2,140 / 6,814

2.4 %101 / 4,159

73.8 %3,423 / 4,636

66.4 %3,187 / 4,802

69.7 %3,416 / 4,903

50.1 %2,723 / 5,433

32.7 %2,030 / 6,200

31.3 %2,046 / 6,539

31.6 %2,031 / 6,429

29.7 %1,995 / 6,712

31.7 %2,075 / 6,541

29.4 %1,967 / 6,701

34.6 %2,117 / 6,112

29.2 %2,169 / 7,435

33.5 %2,124 / 6,348

34.0 %2,086 / 6,137

28.6 %2,160 / 7,544

35.4 %2,189 / 6,176

32.8 %2,112 / 6,445

35.8 %2,209 / 6,162

28.7 %1,907 / 6,649

38.6 %2,502 / 6,481

32.8 %2,243 / 6,838

29.6 %2,245 / 7,573

31.7 %2,208 / 6,957

3.2 %124 / 3,858

70.3 %3,142 / 4,472

79.1 %3,469 / 4,385

54.1 %2,762 / 5,109

34.2 %2,027 / 5,919

32.7 %2,044 / 6,248

33.6 %2,049 / 6,105

31.2 %2,003 / 6,416

33.5 %2,083 / 6,222

30.8 %1,974 / 6,399

36.4 %2,118 / 5,824

31.0 %2,197 / 7,097

35.2 %2,131 / 6,054

36.5 %2,119 / 5,806

28.9 %2,113 / 7,318

37.5 %2,199 / 5,869

34.5 %2,125 / 6,156

38.3 %2,232 / 5,828

30.0 %1,907 / 6,351

39.6 %2,475 / 6,256

34.6 %2,261 / 6,536

30.9 %2,251 / 7,292

33.4 %2,220 / 6,649

2.3 %86 / 3,699

76.4 %3,330 / 4,358

48.8 %2,559 / 5,244

31.4 %1,901 / 6,059

30.4 %1,923 / 6,323

30.8 %1,913 / 6,206

29.2 %1,884 / 6,456

31.7 %1,956 / 6,164

29.4 %1,860 / 6,337

33.2 %1,982 / 5,976

27.9 %2,029 / 7,279

32.0 %1,988 / 6,216

33.0 %1,952 / 5,910

27.0 %1,986 / 7,360

33.7 %2,045 / 6,068

31.4 %1,982 / 6,311

34.2 %2,065 / 6,046

27.4 %1,786 / 6,512

35.6 %2,296 / 6,446

31.9 %2,117 / 6,628

28.4 %2,116 / 7,448

30.4 %2,072 / 6,808

2.6 %104 / 3,965

50.0 %2,713 / 5,423

32.4 %2,004 / 6,187

31.7 %2,023 / 6,375

32.5 %2,014 / 6,201

30.6 %1,973 / 6,458

32.6 %2,065 / 6,330

31.7 %1,948 / 6,142

33.8 %2,088 / 6,186

28.6 %2,145 / 7,488

32.8 %2,103 / 6,410

33.6 %2,064 / 6,148

27.7 %2,099 / 7,586

34.3 %2,152 / 6,267

32.2 %2,100 / 6,515

34.9 %2,180 / 6,239

28.5 %1,903 / 6,680

37.0 %2,429 / 6,572

32.9 %2,225 / 6,753

29.0 %2,217 / 7,641

31.3 %2,189 / 6,996

3.1 %121 / 3,856

37.1 %2,124 / 5,730

35.1 %2,136 / 6,081

36.0 %2,137 / 5,931

33.3 %2,087 / 6,270

36.5 %2,208 / 6,052

33.0 %2,067 / 6,260

39.6 %2,244 / 5,667

32.8 %2,296 / 6,997

38.6 %2,262 / 5,860

39.6 %2,248 / 5,672

32.5 %2,303 / 7,096

41.7 %2,367 / 5,682

36.4 %2,203 / 6,053

39.6 %2,282 / 5,758

30.0 %1,916 / 6,388

44.6 %2,677 / 6,002

37.9 %2,408 / 6,358

33.7 %2,395 / 7,102

37.1 %2,386 / 6,439

4.0 %138 / 3,449

84.5 %3,283 / 3,886

63.7 %2,813 / 4,413

58.4 %2,733 / 4,677

66.0 %2,921 / 4,428

59.9 %2,635 / 4,396

67.1 %3,027 / 4,511

51.9 %2,991 / 5,767

53.8 %2,755 / 5,124

48.4 %2,578 / 5,326

39.3 %2,646 / 6,740

44.7 %2,487 / 5,567

39.7 %2,350 / 5,916

33.0 %2,005 / 6,077

24.7 %1,647 / 6,676

34.7 %2,251 / 6,482

40.2 %2,516 / 6,260

36.0 %2,520 / 6,998

42.4 %2,626 / 6,200

5.1 %187 / 3,663

65.0 %2,884 / 4,436

60.8 %2,856 / 4,696

67.7 %3,051 / 4,508

61.1 %2,758 / 4,512

63.7 %3,065 / 4,814

51.5 %3,068 / 5,962

51.7 %2,797 / 5,408

46.1 %2,608 / 5,656

38.0 %2,683 / 7,059

42.5 %2,509 / 5,902

37.9 %2,368 / 6,253

31.2 %2,012 / 6,439

23.4 %1,651 / 7,053

33.2 %2,265 / 6,832

38.6 %2,543 / 6,595

34.7 %2,544 / 7,335

40.6 %2,651 / 6,536

3.6 %126 / 3,474

68.5 %2,981 / 4,352

68.0 %3,011 / 4,428

57.9 %2,698 / 4,658

62.6 %3,015 / 4,819

52.2 %3,036 / 5,814

51.6 %2,768 / 5,366

47.2 %2,616 / 5,538

38.1 %2,654 / 6,974

43.3 %2,508 / 5,794

38.0 %2,344 / 6,166

32.9 %2,058 / 6,249

23.9 %1,652 / 6,903

33.9 %2,273 / 6,713

39.3 %2,542 / 6,463

35.2 %2,536 / 7,204

41.6 %2,663 / 6,398

4.5 %168 / 3,700

61.6 %2,951 / 4,791

53.8 %2,692 / 5,007

56.8 %2,912 / 5,130

51.1 %3,027 / 5,918

47.5 %2,702 / 5,686

43.5 %2,550 / 5,868

36.2 %2,626 / 7,264

40.6 %2,470 / 6,089

36.3 %2,335 / 6,435

30.7 %2,011 / 6,554

22.4 %1,619 / 7,213

31.7 %2,226 / 7,026

37.0 %2,507 / 6,767

33.3 %2,502 / 7,512

39.2 %2,625 / 6,702

4.6 %171 / 3,727

61.9 %2,837 / 4,581

67.2 %3,191 / 4,749

55.0 %3,192 / 5,801

54.3 %2,915 / 5,371

47.9 %2,691 / 5,621

39.7 %2,781 / 7,007

44.4 %2,605 / 5,861

39.0 %2,430 / 6,233

32.6 %2,081 / 6,383

24.0 %1,688 / 7,037

34.2 %2,330 / 6,822

40.6 %2,645 / 6,520

36.3 %2,639 / 7,260

43.1 %2,778 / 6,445

3.4 %115 / 3,371

54.3 %2,797 / 5,155

44.8 %2,865 / 6,398

46.2 %2,618 / 5,672

41.7 %2,471 / 5,923

34.8 %2,545 / 7,321

39.4 %2,414 / 6,133

34.6 %2,248 / 6,503

29.9 %1,973 / 6,595

22.1 %1,594 / 7,211

30.7 %2,167 / 7,062

36.4 %2,469 / 6,786

32.6 %2,457 / 7,540

37.7 %2,552 / 6,763

4.7 %180 / 3,817

61.5 %3,387 / 5,503

62.6 %3,109 / 4,963

55.6 %2,819 / 5,067

45.4 %2,921 / 6,431

51.4 %2,725 / 5,300

44.1 %2,528 / 5,731

35.9 %2,136 / 5,944

25.7 %1,707 / 6,646

38.4 %2,420 / 6,304

46.8 %2,789 / 5,955

41.6 %2,781 / 6,690

49.2 %2,903 / 5,902

7.4 %348 / 4,686

50.0 %3,105 / 6,216

43.8 %2,826 / 6,446

37.9 %2,942 / 7,760

42.8 %2,803 / 6,552

36.2 %2,549 / 7,038

29.9 %2,171 / 7,273

21.8 %1,741 / 7,987

31.6 %2,426 / 7,684

38.1 %2,796 / 7,337

35.1 %2,818 / 8,022

40.8 %2,948 / 7,218

3.7 %151 / 4,136

52.0 %2,782 / 5,350

43.1 %2,894 / 6,707

48.6 %2,715 / 5,584

42.4 %2,529 / 5,971

34.3 %2,127 / 6,210

25.0 %1,717 / 6,872

36.1 %2,382 / 6,605

44.3 %2,753 / 6,215

40.3 %2,785 / 6,912

45.4 %2,831 / 6,231

3.1 %123 / 3,936

61.6 %3,565 / 5,787

48.9 %2,651 / 5,425

42.3 %2,463 / 5,817

34.6 %2,081 / 6,017

26.2 %1,740 / 6,640

36.1 %2,325 / 6,449

44.9 %2,715 / 6,045

39.6 %2,688 / 6,791

47.0 %2,829 / 6,014

3.2 %174 / 5,358

40.5 %2,759 / 6,808

35.0 %2,532 / 7,230

28.1 %2,102 / 7,487

21.8 %1,766 / 8,096

30.8 %2,404 / 7,808

38.3 %2,833 / 7,404

34.5 %2,808 / 8,142

40.4 %2,965 / 7,341

3.5 %144 / 4,059

49.9 %2,791 / 5,597

39.7 %2,328 / 5,859

25.6 %1,735 / 6,768

40.3 %2,550 / 6,326

49.9 %2,960 / 5,926

45.3 %2,996 / 6,608

48.7 %2,939 / 6,033

2.7 %117 / 4,263

35.2 %2,189 / 6,225

23.9 %1,681 / 7,023

37.0 %2,450 / 6,629

42.1 %2,699 / 6,415

38.2 %2,719 / 7,123

40.4 %2,643 / 6,540

3.5 %140 / 4,038

26.1 %1,755 / 6,734

37.0 %2,400 / 6,495

35.1 %2,325 / 6,626

32.5 %2,372 / 7,305

33.5 %2,256 / 6,738

6.5 %249 / 3,856

27.2 %1,956 / 7,195

23.5 %1,752 / 7,466

21.5 %1,763 / 8,207

23.4 %1,763 / 7,534

4.6 %214 / 4,637

40.5 %2,752 / 6,800

36.9 %2,768 / 7,507

35.3 %2,521 / 7,141

3.8 %181 / 4,741

68.4 %4,131 / 6,038

44.1 %2,952 / 6,696

5.3 %285 / 5,394

39.5 %2,943 / 7,455

3.5 %171 / 4,818

Carsonella ruddiistrain PV

182 proteins, 182 families

Buchnera aphidicola

endosymbiont of Cinara cedri


Buchnera aphidicola

strain APS (endosym

biont of Acyrthosiphon pisum

)


Blochmannia floridanus

endosymbiont of Cam

ponotus floridanus


Blochmannia pennsylvanicus

strain BPEN endosym

biont of Camponotus pennsylvanicus


Wigglesworthia glossinidia

endosymbiont of G

lossina brevipalpis


Ham

iltonella defensa

strain 5AT (endosym


)


Sodalis glossinidius

strain morsitans


Erwinia tasmaniensis

strain Et1/99


Erwinia carotovora

subspecies atroseptica strain SCRI1043


Proteus mirabilis

strain HI4320


Edwardsiella ictaluri

strain 93-146


Dickeya dadantii

strain Ech703


Dickeya zeae

strain Ech1591


Yersinia pseudotuberculosis

strain IP 31758



strain IP 32953


Yersinia pestis

strain Angola


Yersinia pestis

strain Antiqua


/Yersinia enterocolitica

subsp. enterocolitica 8081


Shigella flexneri

2a strain 2457T


Shigella flexneri

2a strain 301




Shigella boydii

strain CDC 3083-94






Escherichia coli

strain BW2952


Escherichia coli

serotype O157:H

7 strain EC4115



strain ATCC 35469


Salmonella_entericastrain


Salmonella enterica

subsp. enterica serovar Paratyphi B str. SPB7


Enterobacter speciesstrain 638


Enterobacter sakazakii

strain ATCC BA

A-894


Pectobacterium carotovorum

strain PC1


Photorhabdus asymbiotica

strain ATCC 43949 (sym

biont of Heterorhabditis indica)


Serratia proteamaculansstrain 568


Klebsiella pneumoniae

strain NTU

H-K2044



strain 342


Citrobacter koseri

strain ATCC BA

A-895


Carso

nella r

uddii

stra

in P

V

182

prote

ins,

182

fam

ilies

Buchner

a aph

idico

la

endosy

mbio

nt of C

inar

a ce

dri

362

prote

ins,

362

fam

ilies

Buchner

a aph

idico

la

stra

in A

PS (e

ndosym

biont o

f Acy

rthosip

hon pisu

m)

567

prote

ins,

565

fam

ilies

Blochm

annia

florid

anus

endosy

mbio

nt of C

amponotu

s flo

ridan

us

583

prote

ins,

583

fam

ilies

Blochm

annia

pennsy

lvan

icus

stra

in B

PEN en

dosym

biont o

f Cam

ponotus p

ennsy

lvan

icus

610

prote

ins,

610

fam

ilies

Wig

gles

worth

ia gl

ossin

idia

endosy

mbio

nt of G

loss

ina

brevip

alpis

617

prote

ins,

617

fam

ilies

Ham

ilton

ella d

efensa

stra

in 5

AT (e

ndosym

biont o

f Acy

rthosip

hon pisu

m)

2,14

8 pro

tein

s, 1,

886

fam

ilies

Sodali

s glos

sinid

ius

stra

in m

orsita

ns

2,51

6 pro

tein

s, 2,

318

fam

ilies

Erwin

ia ta

sman

iensis

stra

in E

t1/99

3,62

2 pro

tein

s, 3,

515

fam

ilies

Erwin

ia ca

roto

vora

subsp

ecie

s atro

septic

a st

rain

SCRI1

043

4,47

2 pro

tein

s, 4,

227

fam

ilies

Proteu

s mira

bilis

stra

in H

I432

0

3,66

2 pro

tein

s, 3,

522

fam

ilies

Edwar

dsiel

la ict

aluri

stra

in 9

3-14

6

3,78

3 pro

tein

s, 3,

556

fam

ilies

Dick

eya d

adan

tii

stra

in E

ch70

3

3,97

0 pro

tein

s, 3,

785

fam

ilies

Dick

eya z

eae

stra

in E

ch15

91

4,16

4 pro

tein

s, 3,

904

fam

ilies

Yersin

ia ps

eudo

tube

rculos

is

stra

in IP

317

58

4,32

4 pro

tein

s, 4,

159

fam

ilies

Yersin

ia ps

eudo

tube

rculos

is

stra

in IP

329

53

4,03

8 pro

tein

s, 3,

858

fam

ilies

Yersin

ia pe

stis

stra

in A

ngola

4,04

0 pro

tein

s, 3,

699

fam

ilies

Yersin

ia pe

stis

stra

in A

ntiqua

4,36

4 pro

tein

s, 3,

965

fam

ilies

/Yer

sinia

enter

ocoli

tica

subsp

. ente

roco

litica

808

1

4,05

1 pro

tein

s, 3,

856

fam

ilies

Shige

lla fl

exner

i

2a st

rain

245

7T

4,06

1 pro

tein

s, 3,

449

fam

ilies

Shige

lla fl

exner

i

2a st

rain

301

4,44

0 pro

tein

s, 3,

663

fam

ilies

Shige

lla bo

ydii

stra

in S

b227

4,28

4 pro

tein

s, 3,

474

fam

ilies

Shige

lla bo

ydii

stra

in C

DC 3

083-

94

4,55

7 pro

tein

s, 3,

700

fam

ilies

Shige

lla so

nnei

stra

in S

s046

4,47

1 pro

tein

s, 3,

727

fam

ilies

Shige

lla d

ysen

teriae

stra

in S

d197

4,50

2 pro

tein

s, 3,

371

fam

ilies

Esche

richi

a coli

stra

in B

W29

52

4,08

4 pro

tein

s, 3,

817

fam

ilies

Esche

richi

a coli

sero

type O

157:

H7

stra

in E

C4115

5,47

7 pro

tein

s, 4,

686

fam

ilies

Esche

richi

a fer

guso

nii

stra

in A

TCC 354

69

4,32

1 pro

tein

s, 4,

136

fam

ilies

Salmon

ella_

enter

ica

stra

in

4,09

3 pro

tein

s, 3,

936

fam

ilies

Salmon

ella e

nterica

subsp

. ente

rica

sero

var P

arat

yphi B st

r. SP

B7

5,59

2 pro

tein

s, 5,

358

fam

ilies

Enterob

acter

spec

ies

stra

in 6

38

4,24

0 pro

tein

s, 4,

059

fam

ilies

Enterob

acter

saka

zakii

stra

in A

TCC BA

A-8

94

4,42

0 pro

tein

s, 4,

263

fam

ilies

Pecto

bacte

rium

caro

tovo

rum

stra

in P

C1

4,24

6 pro

tein

s, 4,

038

fam

ilies

Photo

rhab

dus a

sym

biotic

a

stra

in A

TCC 439

49 (s

ymbio

nt of H

eter

orhab

ditis i

ndica)

4,41

7 pro

tein

s, 3,

856

fam

ilies

Serra

tia p

rotea

mac

ulans

stra

in 5

68

4,94

2 pro

tein

s, 4,

637

fam

ilies

Klebsie

lla p

neum

oniae

stra

in N

TUH

-K20

44

4,99

2 pro

tein

s, 4,

741

fam

ilies

Klebsie

lla p

neum

oniae

stra

in 3

42

5,76

8 pro

tein

s, 5,

394

fam

ilies

Citrob

acter

kose

ri

stra

in A

TCC BA

A-8

95

5,03

1 pro

tein

s, 4,

818

fam

ilies

40 enteric genomes

E. coli

YersiniaShigella

Shigella

0.0 %0 / 182

2.3 %12 / 532

2.0 %15 / 733

0.0 %0 / 765

1.5 %12 / 780

2.3 %18 / 781

0.5 %12 / 2,316

0.4 %11 / 2,684

0.0 %0 / 3,804

0.2 %11 / 4,639

0.0 %0 / 3,844

0.3 %11 / 3,949

0.3 %12 / 4,136

0.3 %11 / 4,331

0.2 %11 / 4,489

0.3 %11 / 4,201

0.3 %11 / 4,206

0.2 %11 / 4,528

0.3 %11 / 4,213

0.2 %10 / 4,228

0.0 %0 / 4,622

0.2 %11 / 4,450

0.2 %11 / 4,723

0.2 %11 / 4,637

0.2 %10 / 4,670

0.3 %11 / 4,248

0.2 %10 / 5,644

0.2 %11 / 4,486

0.3 %11 / 4,259

0.2 %10 / 5,759

0.2 %11 / 4,404

0.2 %10 / 4,587

0.2 %11 / 4,413

0.2 %11 / 4,583

0.2 %11 / 5,106

0.0 %0 / 5,174

0.2 %10 / 5,935

0.2 %10 / 5,199

0.0 %0 / 362

32.8 %229 / 699

0.0 %0 / 945

18.0 %148 / 824

17.0 %142 / 837

6.2 %147 / 2,360

5.7 %154 / 2,719

0.0 %0 / 3,984

3.4 %160 / 4,667

4.2 %161 / 3,856

3.9 %154 / 3,986

3.9 %163 / 4,162

3.7 %160 / 4,361

3.5 %159 / 4,519

3.8 %162 / 4,228

3.6 %154 / 4,241

3.5 %161 / 4,556

3.8 %162 / 4,239

3.8 %161 / 4,254

0.0 %0 / 4,802

3.6 %162 / 4,478

3.4 %162 / 4,749

3.5 %164 / 4,661

3.4 %162 / 4,697

3.8 %164 / 4,272

2.9 %163 / 5,667

3.6 %162 / 4,511

3.9 %167 / 4,280

2.8 %164 / 5,781

3.6 %158 / 4,433

3.6 %165 / 4,608

3.6 %161 / 4,440

3.6 %168 / 4,604

3.1 %161 / 5,130

0.0 %0 / 5,354

2.7 %161 / 5,957

3.1 %161 / 5,224

0.4 %2 / 565

27.4 %247 / 901

29.4 %267 / 908

22.6 %218 / 965

12.6 %304 / 2,405

13.1 %356 / 2,717

10.4 %394 / 3,782

8.2 %382 / 4,642

9.6 %371 / 3,846

8.8 %350 / 3,989

9.2 %383 / 4,141

8.9 %385 / 4,336

8.5 %383 / 4,492

9.2 %386 / 4,202

8.8 %370 / 4,222

8.5 %385 / 4,530

9.4 %394 / 4,204

9.2 %387 / 4,229

8.3 %384 / 4,610

8.7 %388 / 4,453

8.1 %383 / 4,729

8.4 %390 / 4,634

8.1 %381 / 4,679

9.3 %395 / 4,239

7.0 %392 / 5,637

8.9 %397 / 4,474

9.2 %390 / 4,256

6.7 %385 / 5,758

8.8 %387 / 4,403

8.3 %381 / 4,590

8.7 %383 / 4,417

8.4 %387 / 4,585

7.6 %386 / 5,101

7.3 %377 / 5,165

6.3 %374 / 5,941

7.3 %381 / 5,201

0.0 %0 / 583

84.7 %547 / 646

21.1 %209 / 991

11.6 %284 / 2,444

15.4 %414 / 2,681

9.5 %365 / 3,832

8.2 %381 / 4,665

9.4 %363 / 3,872

8.8 %351 / 4,010

9.1 %381 / 4,166

8.6 %377 / 4,365

8.6 %388 / 4,510

9.3 %391 / 4,219

8.8 %372 / 4,240

8.6 %389 / 4,548

9.2 %390 / 4,227

8.6 %369 / 4,267

7.9 %365 / 4,649

8.3 %373 / 4,486

7.8 %370 / 4,761

8.1 %376 / 4,668

7.9 %370 / 4,709

8.8 %375 / 4,281

6.7 %378 / 5,671

8.2 %372 / 4,517

8.7 %373 / 4,294

6.3 %368 / 5,796

8.4 %374 / 4,437

7.9 %366 / 4,626

8.7 %386 / 4,433

8.2 %377 / 4,617

7.6 %388 / 5,119

7.3 %376 / 5,185

6.2 %371 / 5,963

7.3 %379 / 5,225

0.0 %0 / 610

24.2 %239 / 988

14.1 %341 / 2,413

19.3 %504 / 2,618

12.0 %454 / 3,768

10.1 %464 / 4,607

11.6 %442 / 3,821

10.8 %427 / 3,957

11.1 %455 / 4,117

10.7 %461 / 4,305

10.5 %468 / 4,454

11.3 %469 / 4,166

10.7 %450 / 4,189

10.4 %467 / 4,496

11.4 %475 / 4,165

10.8 %455 / 4,206

9.8 %449 / 4,589

10.3 %455 / 4,430

9.7 %454 / 4,703

9.9 %456 / 4,614

9.7 %450 / 4,654

10.8 %456 / 4,225

8.2 %459 / 5,615

10.2 %456 / 4,461

10.7 %453 / 4,239

7.8 %449 / 5,739

10.5 %459 / 4,378

9.8 %446 / 4,572

10.6 %465 / 4,381

9.9 %451 / 4,570

9.3 %471 / 5,059

9.0 %463 / 5,123

7.7 %457 / 5,900

8.8 %453 / 5,173

0.0 %0 / 617

10.5 %262 / 2,496

11.2 %314 / 2,810

7.4 %293 / 3,934

6.3 %301 / 4,776

7.2 %288 / 3,981

6.3 %259 / 4,131

6.7 %289 / 4,290

6.5 %293 / 4,479

6.5 %301 / 4,627

7.0 %303 / 4,339

6.7 %290 / 4,358

6.4 %300 / 4,670

6.9 %301 / 4,352

6.6 %290 / 4,379

6.1 %291 / 4,755

6.4 %295 / 4,597

5.9 %288 / 4,873

6.2 %297 / 4,780

6.0 %290 / 4,818

6.9 %302 / 4,385

5.2 %303 / 5,778

6.6 %303 / 4,622

6.7 %295 / 4,403

5.0 %293 / 5,902

6.6 %302 / 4,542

5.9 %280 / 4,747

6.6 %302 / 4,552

6.2 %295 / 4,732

5.6 %295 / 5,248

5.3 %283 / 5,313

4.7 %283 / 6,086

5.6 %298 / 5,335

6.6 %124 / 1,886

21.8 %819 / 3,757

16.7 %819 / 4,911

14.9 %851 / 5,716

16.0 %797 / 4,976

15.5 %792 / 5,100

15.4 %812 / 5,261

15.2 %828 / 5,433

16.6 %911 / 5,495

17.4 %909 / 5,214

16.7 %879 / 5,256

16.3 %903 / 5,554

17.6 %917 / 5,207

14.9 %798 / 5,352

14.0 %802 / 5,716

14.6 %807 / 5,538

13.8 %807 / 5,848

14.2 %814 / 5,746

14.1 %812 / 5,777

15.1 %811 / 5,370

12.2 %824 / 6,738

14.8 %825 / 5,580

15.3 %822 / 5,370

12.1 %827 / 6,853

15.0 %827 / 5,509

13.9 %796 / 5,721

15.3 %844 / 5,499

14.8 %841 / 5,679

14.4 %880 / 6,130

13.0 %816 / 6,266

11.8 %826 / 7,010

12.9 %812 / 6,310

4.7 %110 / 2,318

31.2 %1,439 / 4,609

27.4 %1,476 / 5,392

26.0 %1,260 / 4,846

27.0 %1,318 / 4,887

28.3 %1,410 / 4,975

28.1 %1,444 / 5,130

27.2 %1,442 / 5,311

29.1 %1,457 / 5,001

26.8 %1,371 / 5,109

26.9 %1,436 / 5,340

29.4 %1,464 / 4,979

27.7 %1,401 / 5,057

25.8 %1,398 / 5,418

26.5 %1,393 / 5,254

24.7 %1,376 / 5,572

26.1 %1,420 / 5,447

24.6 %1,368 / 5,556

28.3 %1,430 / 5,061

22.8 %1,449 / 6,362

27.3 %1,437 / 5,255

28.6 %1,446 / 5,053

22.6 %1,474 / 6,511

28.4 %1,470 / 5,180

26.6 %1,436 / 5,401

28.3 %1,465 / 5,184

23.9 %1,316 / 5,513

26.0 %1,513 / 5,809

24.4 %1,447 / 5,921

21.8 %1,453 / 6,664

23.9 %1,436 / 5,997

2.4 %85 / 3,515

34.7 %2,038 / 5,878

28.7 %1,601 / 5,585

29.6 %1,664 / 5,625

34.7 %1,909 / 5,505

35.3 %1,985 / 5,622

33.6 %1,966 / 5,855

35.5 %1,970 / 5,551

32.2 %1,840 / 5,707

32.4 %1,926 / 5,939

37.2 %2,038 / 5,477

33.2 %1,872 / 5,645

31.4 %1,884 / 5,996

32.8 %1,914 / 5,843

31.1 %1,897 / 6,095

32.4 %1,942 / 6,001

30.2 %1,855 / 6,133

35.6 %1,980 / 5,555

29.4 %2,025 / 6,899

33.9 %1,971 / 5,810

35.9 %1,993 / 5,558

28.2 %1,989 / 7,051

39.4 %2,167 / 5,502

36.5 %2,103 / 5,761

36.2 %2,039 / 5,631

26.2 %1,648 / 6,288

37.0 %2,245 / 6,069

34.8 %2,172 / 6,237

30.9 %2,163 / 6,992

32.6 %2,080 / 6,390

3.7 %155 / 4,227

28.5 %1,776 / 6,228

29.1 %1,829 / 6,275

44.4 %2,494 / 5,618

48.3 %2,697 / 5,584

34.8 %2,216 / 6,370

36.4 %2,215 / 6,090

33.4 %2,062 / 6,180

34.1 %2,179 / 6,395

38.8 %2,315 / 5,965

31.9 %2,015 / 6,308

30.4 %2,028 / 6,667

31.4 %2,040 / 6,491

29.6 %2,012 / 6,805

31.6 %2,093 / 6,623

28.9 %1,976 / 6,833

34.4 %2,123 / 6,179

28.7 %2,163 / 7,529

33.8 %2,161 / 6,398

33.2 %2,079 / 6,263

27.7 %2,130 / 7,691

38.5 %2,342 / 6,078

33.9 %2,188 / 6,454

66.5 %3,329 / 5,008

25.3 %1,754 / 6,945

36.4 %2,425 / 6,659

33.6 %2,304 / 6,866

31.3 %2,362 / 7,545

32.9 %2,284 / 6,943

2.4 %85 / 3,522

30.1 %1,694 / 5,619

28.8 %1,675 / 5,823

28.0 %1,681 / 6,008

30.4 %1,838 / 6,039

31.9 %1,831 / 5,748

29.3 %1,726 / 5,881

29.8 %1,818 / 6,100

33.6 %1,907 / 5,677

28.8 %1,697 / 5,884

27.5 %1,710 / 6,227

27.9 %1,706 / 6,111

26.6 %1,688 / 6,354

27.9 %1,743 / 6,238

26.4 %1,676 / 6,344

30.6 %1,779 / 5,809

25.7 %1,831 / 7,111

29.8 %1,793 / 6,020

30.8 %1,787 / 5,802

25.0 %1,817 / 7,282

30.0 %1,790 / 5,970

26.9 %1,688 / 6,275

28.9 %1,742 / 6,032

29.9 %1,834 / 6,129

29.7 %1,922 / 6,470

26.5 %1,781 / 6,719

24.1 %1,796 / 7,455

26.7 %1,794 / 6,727

2.8 %101 / 3,556

30.1 %1,755 / 5,834

29.4 %1,764 / 5,994

31.7 %1,910 / 6,027

33.4 %1,913 / 5,726

30.4 %1,777 / 5,851

31.0 %1,878 / 6,064

34.3 %1,953 / 5,693

32.0 %1,860 / 5,806

30.9 %1,867 / 6,049

31.1 %1,863 / 5,998

29.1 %1,829 / 6,289

31.2 %1,915 / 6,137

30.7 %1,797 / 5,846

33.9 %1,946 / 5,744

28.3 %1,988 / 7,025

31.9 %1,917 / 6,017

34.0 %1,954 / 5,744

27.8 %1,995 / 7,182

31.0 %1,863 / 6,006

28.8 %1,801 / 6,261

29.8 %1,805 / 6,066

25.0 %1,620 / 6,482

31.4 %2,028 / 6,455

28.4 %1,901 / 6,689

25.4 %1,894 / 7,444

29.3 %1,956 / 6,684

3.1 %118 / 3,785

56.8 %2,820 / 4,964

33.3 %2,026 / 6,079

35.2 %2,031 / 5,776

32.2 %1,907 / 5,924

32.5 %2,001 / 6,153

37.3 %2,117 / 5,678

32.5 %1,911 / 5,875

31.0 %1,927 / 6,219

32.0 %1,946 / 6,081

29.9 %1,908 / 6,373

31.8 %1,969 / 6,191

29.5 %1,886 / 6,394

35.0 %2,023 / 5,787

28.5 %2,037 / 7,146

33.1 %2,006 / 6,066

34.0 %1,989 / 5,858

27.4 %2,004 / 7,317

37.4 %2,162 / 5,781

34.0 %2,072 / 6,094

46.9 %2,515 / 5,357

25.1 %1,649 / 6,577

35.4 %2,261 / 6,380

33.7 %2,191 / 6,492

31.3 %2,244 / 7,165

31.4 %2,086 / 6,647

3.7 %146 / 3,904

33.9 %2,099 / 6,190

35.7 %2,102 / 5,885

32.4 %1,955 / 6,034

33.0 %2,063 / 6,244

36.8 %2,147 / 5,842

32.0 %1,944 / 6,080

30.3 %1,948 / 6,431

31.3 %1,970 / 6,296

29.4 %1,937 / 6,591

31.3 %2,006 / 6,406

30.3 %1,908 / 6,300

34.3 %2,049 / 5,973

28.5 %2,084 / 7,313

32.7 %2,041 / 6,233

33.0 %2,002 / 6,063

26.9 %2,025 / 7,517

37.8 %2,234 / 5,903

34.0 %2,124 / 6,250

49.4 %2,665 / 5,394

25.7 %1,710 / 6,664

35.5 %2,310 / 6,501

34.2 %2,269 / 6,636

31.3 %2,294 / 7,331

31.4 %2,140 / 6,814

2.4 %101 / 4,159

73.8 %3,423 / 4,636

66.4 %3,187 / 4,802

69.7 %3,416 / 4,903

50.1 %2,723 / 5,433

32.7 %2,030 / 6,200

31.3 %2,046 / 6,539

31.6 %2,031 / 6,429

29.7 %1,995 / 6,712

31.7 %2,075 / 6,541

29.4 %1,967 / 6,701

34.6 %2,117 / 6,112

29.2 %2,169 / 7,435

33.5 %2,124 / 6,348

34.0 %2,086 / 6,137

28.6 %2,160 / 7,544

35.4 %2,189 / 6,176

32.8 %2,112 / 6,445

35.8 %2,209 / 6,162

28.7 %1,907 / 6,649

38.6 %2,502 / 6,481

32.8 %2,243 / 6,838

29.6 %2,245 / 7,573

31.7 %2,208 / 6,957

3.2 %124 / 3,858

70.3 %3,142 / 4,472

79.1 %3,469 / 4,385

54.1 %2,762 / 5,109

34.2 %2,027 / 5,919

32.7 %2,044 / 6,248

33.6 %2,049 / 6,105

31.2 %2,003 / 6,416

33.5 %2,083 / 6,222

30.8 %1,974 / 6,399

36.4 %2,118 / 5,824

31.0 %2,197 / 7,097

35.2 %2,131 / 6,054

36.5 %2,119 / 5,806

28.9 %2,113 / 7,318

37.5 %2,199 / 5,869

34.5 %2,125 / 6,156

38.3 %2,232 / 5,828

30.0 %1,907 / 6,351

39.6 %2,475 / 6,256

34.6 %2,261 / 6,536

30.9 %2,251 / 7,292

33.4 %2,220 / 6,649

2.3 %86 / 3,699

76.4 %3,330 / 4,358

48.8 %2,559 / 5,244

31.4 %1,901 / 6,059

30.4 %1,923 / 6,323

30.8 %1,913 / 6,206

29.2 %1,884 / 6,456

31.7 %1,956 / 6,164

29.4 %1,860 / 6,337

33.2 %1,982 / 5,976

27.9 %2,029 / 7,279

32.0 %1,988 / 6,216

33.0 %1,952 / 5,910

27.0 %1,986 / 7,360

33.7 %2,045 / 6,068

31.4 %1,982 / 6,311

34.2 %2,065 / 6,046

27.4 %1,786 / 6,512

35.6 %2,296 / 6,446

31.9 %2,117 / 6,628

28.4 %2,116 / 7,448

30.4 %2,072 / 6,808

2.6 %104 / 3,965

50.0 %2,713 / 5,423

32.4 %2,004 / 6,187

31.7 %2,023 / 6,375

32.5 %2,014 / 6,201

30.6 %1,973 / 6,458

32.6 %2,065 / 6,330

31.7 %1,948 / 6,142

33.8 %2,088 / 6,186

28.6 %2,145 / 7,488

32.8 %2,103 / 6,410

33.6 %2,064 / 6,148

27.7 %2,099 / 7,586

34.3 %2,152 / 6,267

32.2 %2,100 / 6,515

34.9 %2,180 / 6,239

28.5 %1,903 / 6,680

37.0 %2,429 / 6,572

32.9 %2,225 / 6,753

29.0 %2,217 / 7,641

31.3 %2,189 / 6,996

3.1 %121 / 3,856

37.1 %2,124 / 5,730

35.1 %2,136 / 6,081

36.0 %2,137 / 5,931

33.3 %2,087 / 6,270

36.5 %2,208 / 6,052

33.0 %2,067 / 6,260

39.6 %2,244 / 5,667

32.8 %2,296 / 6,997

38.6 %2,262 / 5,860

39.6 %2,248 / 5,672

32.5 %2,303 / 7,096

41.7 %2,367 / 5,682

36.4 %2,203 / 6,053

39.6 %2,282 / 5,758

30.0 %1,916 / 6,388

44.6 %2,677 / 6,002

37.9 %2,408 / 6,358

33.7 %2,395 / 7,102

37.1 %2,386 / 6,439

4.0 %138 / 3,449

84.5 %3,283 / 3,886

63.7 %2,813 / 4,413

58.4 %2,733 / 4,677

66.0 %2,921 / 4,428

59.9 %2,635 / 4,396

67.1 %3,027 / 4,511

51.9 %2,991 / 5,767

53.8 %2,755 / 5,124

48.4 %2,578 / 5,326

39.3 %2,646 / 6,740

44.7 %2,487 / 5,567

39.7 %2,350 / 5,916

33.0 %2,005 / 6,077

24.7 %1,647 / 6,676

34.7 %2,251 / 6,482

40.2 %2,516 / 6,260

36.0 %2,520 / 6,998

42.4 %2,626 / 6,200

5.1 %187 / 3,663

65.0 %2,884 / 4,436

60.8 %2,856 / 4,696

67.7 %3,051 / 4,508

61.1 %2,758 / 4,512

63.7 %3,065 / 4,814

51.5 %3,068 / 5,962

51.7 %2,797 / 5,408

46.1 %2,608 / 5,656

38.0 %2,683 / 7,059

42.5 %2,509 / 5,902

37.9 %2,368 / 6,253

31.2 %2,012 / 6,439

23.4 %1,651 / 7,053

33.2 %2,265 / 6,832

38.6 %2,543 / 6,595

34.7 %2,544 / 7,335

40.6 %2,651 / 6,536

3.6 %126 / 3,474

68.5 %2,981 / 4,352

68.0 %3,011 / 4,428

57.9 %2,698 / 4,658

62.6 %3,015 / 4,819

52.2 %3,036 / 5,814

51.6 %2,768 / 5,366

47.2 %2,616 / 5,538

38.1 %2,654 / 6,974

43.3 %2,508 / 5,794

38.0 %2,344 / 6,166

32.9 %2,058 / 6,249

23.9 %1,652 / 6,903

33.9 %2,273 / 6,713

39.3 %2,542 / 6,463

35.2 %2,536 / 7,204

41.6 %2,663 / 6,398

4.5 %168 / 3,700

61.6 %2,951 / 4,791

53.8 %2,692 / 5,007

56.8 %2,912 / 5,130

51.1 %3,027 / 5,918

47.5 %2,702 / 5,686

43.5 %2,550 / 5,868

36.2 %2,626 / 7,264

40.6 %2,470 / 6,089

36.3 %2,335 / 6,435

30.7 %2,011 / 6,554

22.4 %1,619 / 7,213

31.7 %2,226 / 7,026

37.0 %2,507 / 6,767

33.3 %2,502 / 7,512

39.2 %2,625 / 6,702

4.6 %171 / 3,727

61.9 %2,837 / 4,581

67.2 %3,191 / 4,749

55.0 %3,192 / 5,801

54.3 %2,915 / 5,371

47.9 %2,691 / 5,621

39.7 %2,781 / 7,007

44.4 %2,605 / 5,861

39.0 %2,430 / 6,233

32.6 %2,081 / 6,383

24.0 %1,688 / 7,037

34.2 %2,330 / 6,822

40.6 %2,645 / 6,520

36.3 %2,639 / 7,260

43.1 %2,778 / 6,445

3.4 %115 / 3,371

54.3 %2,797 / 5,155

44.8 %2,865 / 6,398

46.2 %2,618 / 5,672

41.7 %2,471 / 5,923

34.8 %2,545 / 7,321

39.4 %2,414 / 6,133

34.6 %2,248 / 6,503

29.9 %1,973 / 6,595

22.1 %1,594 / 7,211

30.7 %2,167 / 7,062

36.4 %2,469 / 6,786

32.6 %2,457 / 7,540

37.7 %2,552 / 6,763

4.7 %180 / 3,817

61.5 %3,387 / 5,503

62.6 %3,109 / 4,963

55.6 %2,819 / 5,067

45.4 %2,921 / 6,431

51.4 %2,725 / 5,300

44.1 %2,528 / 5,731

35.9 %2,136 / 5,944

25.7 %1,707 / 6,646

38.4 %2,420 / 6,304

46.8 %2,789 / 5,955

41.6 %2,781 / 6,690

49.2 %2,903 / 5,902

7.4 %348 / 4,686

50.0 %3,105 / 6,216

43.8 %2,826 / 6,446

37.9 %2,942 / 7,760

42.8 %2,803 / 6,552

36.2 %2,549 / 7,038

29.9 %2,171 / 7,273

21.8 %1,741 / 7,987

31.6 %2,426 / 7,684

38.1 %2,796 / 7,337

35.1 %2,818 / 8,022

40.8 %2,948 / 7,218

3.7 %151 / 4,136

52.0 %2,782 / 5,350

43.1 %2,894 / 6,707

48.6 %2,715 / 5,584

42.4 %2,529 / 5,971

34.3 %2,127 / 6,210

25.0 %1,717 / 6,872

36.1 %2,382 / 6,605

44.3 %2,753 / 6,215

40.3 %2,785 / 6,912

45.4 %2,831 / 6,231

3.1 %123 / 3,936

61.6 %3,565 / 5,787

48.9 %2,651 / 5,425

42.3 %2,463 / 5,817

34.6 %2,081 / 6,017

26.2 %1,740 / 6,640

36.1 %2,325 / 6,449

44.9 %2,715 / 6,045

39.6 %2,688 / 6,791

47.0 %2,829 / 6,014

3.2 %174 / 5,358

40.5 %2,759 / 6,808

35.0 %2,532 / 7,230

28.1 %2,102 / 7,487

21.8 %1,766 / 8,096

30.8 %2,404 / 7,808

38.3 %2,833 / 7,404

34.5 %2,808 / 8,142

40.4 %2,965 / 7,341

3.5 %144 / 4,059

49.9 %2,791 / 5,597

39.7 %2,328 / 5,859

25.6 %1,735 / 6,768

40.3 %2,550 / 6,326

49.9 %2,960 / 5,926

45.3 %2,996 / 6,608

48.7 %2,939 / 6,033

2.7 %117 / 4,263

35.2 %2,189 / 6,225

23.9 %1,681 / 7,023

37.0 %2,450 / 6,629

42.1 %2,699 / 6,415

38.2 %2,719 / 7,123

40.4 %2,643 / 6,540

3.5 %140 / 4,038

26.1 %1,755 / 6,734

37.0 %2,400 / 6,495

35.1 %2,325 / 6,626

32.5 %2,372 / 7,305

33.5 %2,256 / 6,738

6.5 %249 / 3,856

27.2 %1,956 / 7,195

23.5 %1,752 / 7,466

21.5 %1,763 / 8,207

23.4 %1,763 / 7,534

4.6 %214 / 4,637

40.5 %2,752 / 6,800

36.9 %2,768 / 7,507

35.3 %2,521 / 7,141

3.8 %181 / 4,741

68.4 %4,131 / 6,038

44.1 %2,952 / 6,696

5.3 %285 / 5,394

39.5 %2,943 / 7,455

3.5 %171 / 4,818



Buchnera aphidicola



Buchnera aphidicola

strain APS (endosym


)



endosymbiont of Cam

ponotus floridanus



strain BPEN endosym




endosymbiont of G

lossina brevipalpis


Ham

iltonella defensa

strain 5AT (endosym


)



strain morsitans



strain Et1/99


Erwinia carotovora



Proteus mirabilis

strain HI4320



strain 93-146


Dickeya dadantii

strain Ech703


Dickeya zeae

strain Ech1591



strain IP 31758



strain IP 32953


Yersinia pestis

strain Angola


Yersinia pestis

strain Antiqua





Shigella flexneri

2a strain 2457T


Shigella flexneri

2a strain 301




Shigella boydii

strain CDC 3083-94






Escherichia coli

strain BW2952


Escherichia coli

serotype O157:H

7 strain EC4115



strain ATCC 35469




Salmonella enterica






strain ATCC BA

A-894



strain PC1









strain NTU

H-K2044



strain 342


Citrobacter koseri

strain ATCC BA

A-895


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endosy

mbio

nt of G

loss

ina

brevip

alpis

617

prote

ins,

617

fam

ilies

Ham

ilton

ella d

efensa

stra

in 5

AT (e

ndosym

biont o

f Acy

rthosip

hon pisu

m)

2,14

8 pro

tein

s, 1,

886

fam

ilies

Sodali

s glos

sinid

ius

stra

in m

orsita

ns

2,51

6 pro

tein

s, 2,

318

fam

ilies

Erwin

ia ta

sman

iensis

stra

in E

t1/99

3,62

2 pro

tein

s, 3,

515

fam

ilies

Erwin

ia ca

roto

vora

subsp

ecie

s atro

septic

a st

rain

SCRI1

043

4,47

2 pro

tein

s, 4,

227

fam

ilies

Proteu

s mira

bilis

stra

in H

I432

0

3,66

2 pro

tein

s, 3,

522

fam

ilies

Edwar

dsiel

la ict

aluri

stra

in 9

3-14

6

3,78

3 pro

tein

s, 3,

556

fam

ilies

Dick

eya d

adan

tii

stra

in E

ch70

3

3,97

0 pro

tein

s, 3,

785

fam

ilies

Dick

eya z

eae

stra

in E

ch15

91

4,16

4 pro

tein

s, 3,

904

fam

ilies

Yersin

ia ps

eudo

tube

rculos

is

stra

in IP

317

58

4,32

4 pro

tein

s, 4,

159

fam

ilies

Yersin

ia ps

eudo

tube

rculos

is

stra

in IP

329

53

4,03

8 pro

tein

s, 3,

858

fam

ilies

Yersin

ia pe

stis

stra

in A

ngola

4,04

0 pro

tein

s, 3,

699

fam

ilies

Yersin

ia pe

stis

stra

in A

ntiqua

4,36

4 pro

tein

s, 3,

965

fam

ilies

/Yer

sinia

enter

ocoli

tica

subsp

. ente

roco

litica

808

1

4,05

1 pro

tein

s, 3,

856

fam

ilies

Shige

lla fl

exner

i

2a st

rain

245

7T

4,06

1 pro

tein

s, 3,

449

fam

ilies

Shige

lla fl

exner

i

2a st

rain

301

4,44

0 pro

tein

s, 3,

663

fam

ilies

Shige

lla bo

ydii

stra

in S

b227

4,28

4 pro

tein

s, 3,

474

fam

ilies

Shige

lla bo

ydii

stra

in C

DC 3

083-

94

4,55

7 pro

tein

s, 3,

700

fam

ilies

Shige

lla so

nnei

stra

in S

s046

4,47

1 pro

tein

s, 3,

727

fam

ilies

Shige

lla d

ysen

teriae

stra

in S

d197

4,50

2 pro

tein

s, 3,

371

fam

ilies

Esche

richi

a coli

stra

in B

W29

52

4,08

4 pro

tein

s, 3,

817

fam

ilies

Esche

richi

a coli

sero

type O

157:

H7

stra

in E

C4115

5,47

7 pro

tein

s, 4,

686

fam

ilies

Esche

richi

a fer

guso

nii

stra

in A

TCC 354

69

4,32

1 pro

tein

s, 4,

136

fam

ilies

Salmon

ella_

enter

ica

stra

in

4,09

3 pro

tein

s, 3,

936

fam

ilies

Salmon

ella e

nterica

subsp

. ente

rica

sero

var P

arat

yphi B st

r. SP

B7

5,59

2 pro

tein

s, 5,

358

fam

ilies

Enterob

acter

spec

ies

stra

in 6

38

4,24

0 pro

tein

s, 4,

059

fam

ilies

Enterob

acter

saka

zakii

stra

in A

TCC BA

A-8

94

4,42

0 pro

tein

s, 4,

263

fam

ilies

Pecto

bacte

rium

caro

tovo

rum

stra

in P

C1

4,24

6 pro

tein

s, 4,

038

fam

ilies

Photo

rhab

dus a

sym

biotic

a

stra

in A

TCC 439

49 (s

ymbio

nt of H

eter

orhab

ditis i

ndica)

4,41

7 pro

tein

s, 3,

856

fam

ilies

Serra

tia p

rotea

mac

ulans

stra

in 5

68

4,94

2 pro

tein

s, 4,

637

fam

ilies

Klebsie

lla p

neum

oniae

stra

in N

TUH

-K20

44

4,99

2 pro

tein

s, 4,

741

fam

ilies

Klebsie

lla p

neum

oniae

stra

in 3

42

5,76

8 pro

tein

s, 5,

394

fam

ilies

Citrob

acter

kose

ri

stra

in A

TCC BA

A-8

95

5,03

1 pro

tein

s, 4,

818

fam

ilies


20.0 %0.0 %


100.0 %0.0 %

0.0 %0 / 182

2.3 %12 / 532

2.0 %15 / 733

0.0 %0 / 765

1.5 %12 / 780

2.3 %18 / 781

0.5 %12 / 2,316

0.4 %11 / 2,684

0.0 %0 / 3,804

0.2 %11 / 4,639

0.0 %0 / 3,844

0.3 %11 / 3,949

0.3 %12 / 4,136

0.3 %11 / 4,331

0.2 %11 / 4,489

0.3 %11 / 4,201

0.3 %11 / 4,206

0.2 %11 / 4,528

0.3 %11 / 4,213

0.2 %10 / 4,228

0.0 %0 / 4,622

0.2 %11 / 4,450

0.2 %11 / 4,723

0.2 %11 / 4,637

0.2 %10 / 4,670

0.3 %11 / 4,248

0.2 %10 / 5,644

0.2 %11 / 4,486

0.3 %11 / 4,259

0.2 %10 / 5,759

0.2 %11 / 4,404

0.2 %10 / 4,587

0.2 %11 / 4,413

0.2 %11 / 4,583

0.2 %11 / 5,106

0.0 %0 / 5,174

0.2 %10 / 5,935

0.2 %10 / 5,199

0.0 %0 / 362

32.8 %229 / 699

0.0 %0 / 945

18.0 %148 / 824

17.0 %142 / 837

6.2 %147 / 2,360

5.7 %154 / 2,719

0.0 %0 / 3,984

3.4 %160 / 4,667

4.2 %161 / 3,856

3.9 %154 / 3,986

3.9 %163 / 4,162

3.7 %160 / 4,361

3.5 %159 / 4,519

3.8 %162 / 4,228

3.6 %154 / 4,241

3.5 %161 / 4,556

3.8 %162 / 4,239

3.8 %161 / 4,254

0.0 %0 / 4,802

3.6 %162 / 4,478

3.4 %162 / 4,749

3.5 %164 / 4,661

3.4 %162 / 4,697

3.8 %164 / 4,272

2.9 %163 / 5,667

3.6 %162 / 4,511

3.9 %167 / 4,280

2.8 %164 / 5,781

3.6 %158 / 4,433

3.6 %165 / 4,608

3.6 %161 / 4,440

3.6 %168 / 4,604

3.1 %161 / 5,130

0.0 %0 / 5,354

2.7 %161 / 5,957

3.1 %161 / 5,224

0.4 %2 / 565

27.4 %247 / 901

29.4 %267 / 908

22.6 %218 / 965

12.6 %304 / 2,405

13.1 %356 / 2,717

10.4 %394 / 3,782

8.2 %382 / 4,642

9.6 %371 / 3,846

8.8 %350 / 3,989

9.2 %383 / 4,141

8.9 %385 / 4,336

8.5 %383 / 4,492

9.2 %386 / 4,202

8.8 %370 / 4,222

8.5 %385 / 4,530

9.4 %394 / 4,204

9.2 %387 / 4,229

8.3 %384 / 4,610

8.7 %388 / 4,453

8.1 %383 / 4,729

8.4 %390 / 4,634

8.1 %381 / 4,679

9.3 %395 / 4,239

7.0 %392 / 5,637

8.9 %397 / 4,474

9.2 %390 / 4,256

6.7 %385 / 5,758

8.8 %387 / 4,403

8.3 %381 / 4,590

8.7 %383 / 4,417

8.4 %387 / 4,585

7.6 %386 / 5,101

7.3 %377 / 5,165

6.3 %374 / 5,941

7.3 %381 / 5,201

0.0 %0 / 583

84.7 %547 / 646

21.1 %209 / 991

11.6 %284 / 2,444

15.4 %414 / 2,681

9.5 %365 / 3,832

8.2 %381 / 4,665

9.4 %363 / 3,872

8.8 %351 / 4,010

9.1 %381 / 4,166

8.6 %377 / 4,365

8.6 %388 / 4,510

9.3 %391 / 4,219

8.8 %372 / 4,240

8.6 %389 / 4,548

9.2 %390 / 4,227

8.6 %369 / 4,267

7.9 %365 / 4,649

8.3 %373 / 4,486

7.8 %370 / 4,761

8.1 %376 / 4,668

7.9 %370 / 4,709

8.8 %375 / 4,281

6.7 %378 / 5,671

8.2 %372 / 4,517

8.7 %373 / 4,294

6.3 %368 / 5,796

8.4 %374 / 4,437

7.9 %366 / 4,626

8.7 %386 / 4,433

8.2 %377 / 4,617

7.6 %388 / 5,119

7.3 %376 / 5,185

6.2 %371 / 5,963

7.3 %379 / 5,225

0.0 %0 / 610

24.2 %239 / 988

14.1 %341 / 2,413

19.3 %504 / 2,618

12.0 %454 / 3,768

10.1 %464 / 4,607

11.6 %442 / 3,821

10.8 %427 / 3,957

11.1 %455 / 4,117

10.7 %461 / 4,305

10.5 %468 / 4,454

11.3 %469 / 4,166

10.7 %450 / 4,189

10.4 %467 / 4,496

11.4 %475 / 4,165

10.8 %455 / 4,206

9.8 %449 / 4,589

10.3 %455 / 4,430

9.7 %454 / 4,703

9.9 %456 / 4,614

9.7 %450 / 4,654

10.8 %456 / 4,225

8.2 %459 / 5,615

10.2 %456 / 4,461

10.7 %453 / 4,239

7.8 %449 / 5,739

10.5 %459 / 4,378

9.8 %446 / 4,572

10.6 %465 / 4,381

9.9 %451 / 4,570

9.3 %471 / 5,059

9.0 %463 / 5,123

7.7 %457 / 5,900

8.8 %453 / 5,173

0.0 %0 / 617

10.5 %262 / 2,496

11.2 %314 / 2,810

7.4 %293 / 3,934

6.3 %301 / 4,776

7.2 %288 / 3,981

6.3 %259 / 4,131

6.7 %289 / 4,290

6.5 %293 / 4,479

6.5 %301 / 4,627

7.0 %303 / 4,339

6.7 %290 / 4,358

6.4 %300 / 4,670

6.9 %301 / 4,352

6.6 %290 / 4,379

6.1 %291 / 4,755

6.4 %295 / 4,597

5.9 %288 / 4,873

6.2 %297 / 4,780

6.0 %290 / 4,818

6.9 %302 / 4,385

5.2 %303 / 5,778

6.6 %303 / 4,622

6.7 %295 / 4,403

5.0 %293 / 5,902

6.6 %302 / 4,542

5.9 %280 / 4,747

6.6 %302 / 4,552

6.2 %295 / 4,732

5.6 %295 / 5,248

5.3 %283 / 5,313

4.7 %283 / 6,086

5.6 %298 / 5,335

6.6 %124 / 1,886

21.8 %819 / 3,757

16.7 %819 / 4,911

14.9 %851 / 5,716

16.0 %797 / 4,976

15.5 %792 / 5,100

15.4 %812 / 5,261

15.2 %828 / 5,433

16.6 %911 / 5,495

17.4 %909 / 5,214

16.7 %879 / 5,256

16.3 %903 / 5,554

17.6 %917 / 5,207

14.9 %798 / 5,352

14.0 %802 / 5,716

14.6 %807 / 5,538

13.8 %807 / 5,848

14.2 %814 / 5,746

14.1 %812 / 5,777

15.1 %811 / 5,370

12.2 %824 / 6,738

14.8 %825 / 5,580

15.3 %822 / 5,370

12.1 %827 / 6,853

15.0 %827 / 5,509

13.9 %796 / 5,721

15.3 %844 / 5,499

14.8 %841 / 5,679

14.4 %880 / 6,130

13.0 %816 / 6,266

11.8 %826 / 7,010

12.9 %812 / 6,310

4.7 %110 / 2,318

31.2 %1,439 / 4,609

27.4 %1,476 / 5,392

26.0 %1,260 / 4,846

27.0 %1,318 / 4,887

28.3 %1,410 / 4,975

28.1 %1,444 / 5,130

27.2 %1,442 / 5,311

29.1 %1,457 / 5,001

26.8 %1,371 / 5,109

26.9 %1,436 / 5,340

29.4 %1,464 / 4,979

27.7 %1,401 / 5,057

25.8 %1,398 / 5,418

26.5 %1,393 / 5,254

24.7 %1,376 / 5,572

26.1 %1,420 / 5,447

24.6 %1,368 / 5,556

28.3 %1,430 / 5,061

22.8 %1,449 / 6,362

27.3 %1,437 / 5,255

28.6 %1,446 / 5,053

22.6 %1,474 / 6,511

28.4 %1,470 / 5,180

26.6 %1,436 / 5,401

28.3 %1,465 / 5,184

23.9 %1,316 / 5,513

26.0 %1,513 / 5,809

24.4 %1,447 / 5,921

21.8 %1,453 / 6,664

23.9 %1,436 / 5,997

2.4 %85 / 3,515

34.7 %2,038 / 5,878

28.7 %1,601 / 5,585

29.6 %1,664 / 5,625

34.7 %1,909 / 5,505

35.3 %1,985 / 5,622

33.6 %1,966 / 5,855

35.5 %1,970 / 5,551

32.2 %1,840 / 5,707

32.4 %1,926 / 5,939

37.2 %2,038 / 5,477

33.2 %1,872 / 5,645

31.4 %1,884 / 5,996

32.8 %1,914 / 5,843

31.1 %1,897 / 6,095

32.4 %1,942 / 6,001

30.2 %1,855 / 6,133

35.6 %1,980 / 5,555

29.4 %2,025 / 6,899

33.9 %1,971 / 5,810

35.9 %1,993 / 5,558

28.2 %1,989 / 7,051

39.4 %2,167 / 5,502

36.5 %2,103 / 5,761

36.2 %2,039 / 5,631

26.2 %1,648 / 6,288

37.0 %2,245 / 6,069

34.8 %2,172 / 6,237

30.9 %2,163 / 6,992

32.6 %2,080 / 6,390

3.7 %155 / 4,227

28.5 %1,776 / 6,228

29.1 %1,829 / 6,275

44.4 %2,494 / 5,618

48.3 %2,697 / 5,584

34.8 %2,216 / 6,370

36.4 %2,215 / 6,090

33.4 %2,062 / 6,180

34.1 %2,179 / 6,395

38.8 %2,315 / 5,965

31.9 %2,015 / 6,308

30.4 %2,028 / 6,667

31.4 %2,040 / 6,491

29.6 %2,012 / 6,805

31.6 %2,093 / 6,623

28.9 %1,976 / 6,833

34.4 %2,123 / 6,179

28.7 %2,163 / 7,529

33.8 %2,161 / 6,398

33.2 %2,079 / 6,263

27.7 %2,130 / 7,691

38.5 %2,342 / 6,078

33.9 %2,188 / 6,454

66.5 %3,329 / 5,008

25.3 %1,754 / 6,945

36.4 %2,425 / 6,659

33.6 %2,304 / 6,866

31.3 %2,362 / 7,545

32.9 %2,284 / 6,943

2.4 %85 / 3,522

30.1 %1,694 / 5,619

28.8 %1,675 / 5,823

28.0 %1,681 / 6,008

30.4 %1,838 / 6,039

31.9 %1,831 / 5,748

29.3 %1,726 / 5,881

29.8 %1,818 / 6,100

33.6 %1,907 / 5,677

28.8 %1,697 / 5,884

27.5 %1,710 / 6,227

27.9 %1,706 / 6,111

26.6 %1,688 / 6,354

27.9 %1,743 / 6,238

26.4 %1,676 / 6,344

30.6 %1,779 / 5,809

25.7 %1,831 / 7,111

29.8 %1,793 / 6,020

30.8 %1,787 / 5,802

25.0 %1,817 / 7,282

30.0 %1,790 / 5,970

26.9 %1,688 / 6,275

28.9 %1,742 / 6,032

29.9 %1,834 / 6,129

29.7 %1,922 / 6,470

26.5 %1,781 / 6,719

24.1 %1,796 / 7,455

26.7 %1,794 / 6,727

2.8 %101 / 3,556

30.1 %1,755 / 5,834

29.4 %1,764 / 5,994

31.7 %1,910 / 6,027

33.4 %1,913 / 5,726

30.4 %1,777 / 5,851

31.0 %1,878 / 6,064

34.3 %1,953 / 5,693

32.0 %1,860 / 5,806

30.9 %1,867 / 6,049

31.1 %1,863 / 5,998

29.1 %1,829 / 6,289

31.2 %1,915 / 6,137

30.7 %1,797 / 5,846

33.9 %1,946 / 5,744

28.3 %1,988 / 7,025

31.9 %1,917 / 6,017

34.0 %1,954 / 5,744

27.8 %1,995 / 7,182

31.0 %1,863 / 6,006

28.8 %1,801 / 6,261

29.8 %1,805 / 6,066

25.0 %1,620 / 6,482

31.4 %2,028 / 6,455

28.4 %1,901 / 6,689

25.4 %1,894 / 7,444

29.3 %1,956 / 6,684

3.1 %118 / 3,785

56.8 %2,820 / 4,964

33.3 %2,026 / 6,079

35.2 %2,031 / 5,776

32.2 %1,907 / 5,924

32.5 %2,001 / 6,153

37.3 %2,117 / 5,678

32.5 %1,911 / 5,875

31.0 %1,927 / 6,219

32.0 %1,946 / 6,081

29.9 %1,908 / 6,373

31.8 %1,969 / 6,191

29.5 %1,886 / 6,394

35.0 %2,023 / 5,787

28.5 %2,037 / 7,146

33.1 %2,006 / 6,066

34.0 %1,989 / 5,858

27.4 %2,004 / 7,317

37.4 %2,162 / 5,781

34.0 %2,072 / 6,094

46.9 %2,515 / 5,357

25.1 %1,649 / 6,577

35.4 %2,261 / 6,380

33.7 %2,191 / 6,492

31.3 %2,244 / 7,165

31.4 %2,086 / 6,647

3.7 %146 / 3,904

33.9 %2,099 / 6,190

35.7 %2,102 / 5,885

32.4 %1,955 / 6,034

33.0 %2,063 / 6,244

36.8 %2,147 / 5,842

32.0 %1,944 / 6,080

30.3 %1,948 / 6,431

31.3 %1,970 / 6,296

29.4 %1,937 / 6,591

31.3 %2,006 / 6,406

30.3 %1,908 / 6,300

34.3 %2,049 / 5,973

28.5 %2,084 / 7,313

32.7 %2,041 / 6,233

33.0 %2,002 / 6,063

26.9 %2,025 / 7,517

37.8 %2,234 / 5,903

34.0 %2,124 / 6,250

49.4 %2,665 / 5,394

25.7 %1,710 / 6,664

35.5 %2,310 / 6,501

34.2 %2,269 / 6,636

31.3 %2,294 / 7,331

31.4 %2,140 / 6,814

2.4 %101 / 4,159

73.8 %3,423 / 4,636

66.4 %3,187 / 4,802

69.7 %3,416 / 4,903

50.1 %2,723 / 5,433

32.7 %2,030 / 6,200

31.3 %2,046 / 6,539

31.6 %2,031 / 6,429

29.7 %1,995 / 6,712

31.7 %2,075 / 6,541

29.4 %1,967 / 6,701

34.6 %2,117 / 6,112

29.2 %2,169 / 7,435

33.5 %2,124 / 6,348

34.0 %2,086 / 6,137

28.6 %2,160 / 7,544

35.4 %2,189 / 6,176

32.8 %2,112 / 6,445

35.8 %2,209 / 6,162

28.7 %1,907 / 6,649

38.6 %2,502 / 6,481

32.8 %2,243 / 6,838

29.6 %2,245 / 7,573

31.7 %2,208 / 6,957

3.2 %124 / 3,858

70.3 %3,142 / 4,472

79.1 %3,469 / 4,385

54.1 %2,762 / 5,109

34.2 %2,027 / 5,919

32.7 %2,044 / 6,248

33.6 %2,049 / 6,105

31.2 %2,003 / 6,416

33.5 %2,083 / 6,222

30.8 %1,974 / 6,399

36.4 %2,118 / 5,824

31.0 %2,197 / 7,097

35.2 %2,131 / 6,054

36.5 %2,119 / 5,806

28.9 %2,113 / 7,318

37.5 %2,199 / 5,869

34.5 %2,125 / 6,156

38.3 %2,232 / 5,828

30.0 %1,907 / 6,351

39.6 %2,475 / 6,256

34.6 %2,261 / 6,536

30.9 %2,251 / 7,292

33.4 %2,220 / 6,649

2.3 %86 / 3,699

76.4 %3,330 / 4,358

48.8 %2,559 / 5,244

31.4 %1,901 / 6,059

30.4 %1,923 / 6,323

30.8 %1,913 / 6,206

29.2 %1,884 / 6,456

31.7 %1,956 / 6,164

29.4 %1,860 / 6,337

33.2 %1,982 / 5,976

27.9 %2,029 / 7,279

32.0 %1,988 / 6,216

33.0 %1,952 / 5,910

27.0 %1,986 / 7,360

33.7 %2,045 / 6,068

31.4 %1,982 / 6,311

34.2 %2,065 / 6,046

27.4 %1,786 / 6,512

35.6 %2,296 / 6,446

31.9 %2,117 / 6,628

28.4 %2,116 / 7,448

30.4 %2,072 / 6,808

2.6 %104 / 3,965

50.0 %2,713 / 5,423

32.4 %2,004 / 6,187

31.7 %2,023 / 6,375

32.5 %2,014 / 6,201

30.6 %1,973 / 6,458

32.6 %2,065 / 6,330

31.7 %1,948 / 6,142

33.8 %2,088 / 6,186

28.6 %2,145 / 7,488

32.8 %2,103 / 6,410

33.6 %2,064 / 6,148

27.7 %2,099 / 7,586

34.3 %2,152 / 6,267

32.2 %2,100 / 6,515

34.9 %2,180 / 6,239

28.5 %1,903 / 6,680

37.0 %2,429 / 6,572

32.9 %2,225 / 6,753

29.0 %2,217 / 7,641

31.3 %2,189 / 6,996

3.1 %121 / 3,856

37.1 %2,124 / 5,730

35.1 %2,136 / 6,081

36.0 %2,137 / 5,931

33.3 %2,087 / 6,270

36.5 %2,208 / 6,052

33.0 %2,067 / 6,260

39.6 %2,244 / 5,667

32.8 %2,296 / 6,997

38.6 %2,262 / 5,860

39.6 %2,248 / 5,672

32.5 %2,303 / 7,096

41.7 %2,367 / 5,682

36.4 %2,203 / 6,053

39.6 %2,282 / 5,758

30.0 %1,916 / 6,388

44.6 %2,677 / 6,002

37.9 %2,408 / 6,358

33.7 %2,395 / 7,102

37.1 %2,386 / 6,439

4.0 %138 / 3,449

84.5 %3,283 / 3,886

63.7 %2,813 / 4,413

58.4 %2,733 / 4,677

66.0 %2,921 / 4,428

59.9 %2,635 / 4,396

67.1 %3,027 / 4,511

51.9 %2,991 / 5,767

53.8 %2,755 / 5,124

48.4 %2,578 / 5,326

39.3 %2,646 / 6,740

44.7 %2,487 / 5,567

39.7 %2,350 / 5,916

33.0 %2,005 / 6,077

24.7 %1,647 / 6,676

34.7 %2,251 / 6,482

40.2 %2,516 / 6,260

36.0 %2,520 / 6,998

42.4 %2,626 / 6,200

5.1 %187 / 3,663

65.0 %2,884 / 4,436

60.8 %2,856 / 4,696

67.7 %3,051 / 4,508

61.1 %2,758 / 4,512

63.7 %3,065 / 4,814

51.5 %3,068 / 5,962

51.7 %2,797 / 5,408

46.1 %2,608 / 5,656

38.0 %2,683 / 7,059

42.5 %2,509 / 5,902

37.9 %2,368 / 6,253

31.2 %2,012 / 6,439

23.4 %1,651 / 7,053

33.2 %2,265 / 6,832

38.6 %2,543 / 6,595

34.7 %2,544 / 7,335

40.6 %2,651 / 6,536

3.6 %126 / 3,474

68.5 %2,981 / 4,352

68.0 %3,011 / 4,428

57.9 %2,698 / 4,658

62.6 %3,015 / 4,819

52.2 %3,036 / 5,814

51.6 %2,768 / 5,366

47.2 %2,616 / 5,538

38.1 %2,654 / 6,974

43.3 %2,508 / 5,794

38.0 %2,344 / 6,166

32.9 %2,058 / 6,249

23.9 %1,652 / 6,903

33.9 %2,273 / 6,713

39.3 %2,542 / 6,463

35.2 %2,536 / 7,204

41.6 %2,663 / 6,398

4.5 %168 / 3,700

61.6 %2,951 / 4,791

53.8 %2,692 / 5,007

56.8 %2,912 / 5,130

51.1 %3,027 / 5,918

47.5 %2,702 / 5,686

43.5 %2,550 / 5,868

36.2 %2,626 / 7,264

40.6 %2,470 / 6,089

36.3 %2,335 / 6,435

30.7 %2,011 / 6,554

22.4 %1,619 / 7,213

31.7 %2,226 / 7,026

37.0 %2,507 / 6,767

33.3 %2,502 / 7,512

39.2 %2,625 / 6,702

4.6 %171 / 3,727

61.9 %2,837 / 4,581

67.2 %3,191 / 4,749

55.0 %3,192 / 5,801

54.3 %2,915 / 5,371

47.9 %2,691 / 5,621

39.7 %2,781 / 7,007

44.4 %2,605 / 5,861

39.0 %2,430 / 6,233

32.6 %2,081 / 6,383

24.0 %1,688 / 7,037

34.2 %2,330 / 6,822

40.6 %2,645 / 6,520

36.3 %2,639 / 7,260

43.1 %2,778 / 6,445

3.4 %115 / 3,371

54.3 %2,797 / 5,155

44.8 %2,865 / 6,398

46.2 %2,618 / 5,672

41.7 %2,471 / 5,923

34.8 %2,545 / 7,321

39.4 %2,414 / 6,133

34.6 %2,248 / 6,503

29.9 %1,973 / 6,595

22.1 %1,594 / 7,211

30.7 %2,167 / 7,062

36.4 %2,469 / 6,786

32.6 %2,457 / 7,540

37.7 %2,552 / 6,763

4.7 %180 / 3,817

61.5 %3,387 / 5,503

62.6 %3,109 / 4,963

55.6 %2,819 / 5,067

45.4 %2,921 / 6,431

51.4 %2,725 / 5,300

44.1 %2,528 / 5,731

35.9 %2,136 / 5,944

25.7 %1,707 / 6,646

38.4 %2,420 / 6,304

46.8 %2,789 / 5,955

41.6 %2,781 / 6,690

49.2 %2,903 / 5,902

7.4 %348 / 4,686

50.0 %3,105 / 6,216

43.8 %2,826 / 6,446

37.9 %2,942 / 7,760

42.8 %2,803 / 6,552

36.2 %2,549 / 7,038

29.9 %2,171 / 7,273

21.8 %1,741 / 7,987

31.6 %2,426 / 7,684

38.1 %2,796 / 7,337

35.1 %2,818 / 8,022

40.8 %2,948 / 7,218

3.7 %151 / 4,136

52.0 %2,782 / 5,350

43.1 %2,894 / 6,707

48.6 %2,715 / 5,584

42.4 %2,529 / 5,971

34.3 %2,127 / 6,210

25.0 %1,717 / 6,872

36.1 %2,382 / 6,605

44.3 %2,753 / 6,215

40.3 %2,785 / 6,912

45.4 %2,831 / 6,231

3.1 %123 / 3,936

61.6 %3,565 / 5,787

48.9 %2,651 / 5,425

42.3 %2,463 / 5,817

34.6 %2,081 / 6,017

26.2 %1,740 / 6,640

36.1 %2,325 / 6,449

44.9 %2,715 / 6,045

39.6 %2,688 / 6,791

47.0 %2,829 / 6,014

3.2 %174 / 5,358

40.5 %2,759 / 6,808

35.0 %2,532 / 7,230

28.1 %2,102 / 7,487

21.8 %1,766 / 8,096

30.8 %2,404 / 7,808

38.3 %2,833 / 7,404

34.5 %2,808 / 8,142

40.4 %2,965 / 7,341

3.5 %144 / 4,059

49.9 %2,791 / 5,597

39.7 %2,328 / 5,859

25.6 %1,735 / 6,768

40.3 %2,550 / 6,326

49.9 %2,960 / 5,926

45.3 %2,996 / 6,608

48.7 %2,939 / 6,033

2.7 %117 / 4,263

35.2 %2,189 / 6,225

23.9 %1,681 / 7,023

37.0 %2,450 / 6,629

42.1 %2,699 / 6,415

38.2 %2,719 / 7,123

40.4 %2,643 / 6,540

3.5 %140 / 4,038

26.1 %1,755 / 6,734

37.0 %2,400 / 6,495

35.1 %2,325 / 6,626

32.5 %2,372 / 7,305

33.5 %2,256 / 6,738

6.5 %249 / 3,856

27.2 %1,956 / 7,195

23.5 %1,752 / 7,466

21.5 %1,763 / 8,207

23.4 %1,763 / 7,534

4.6 %214 / 4,637

40.5 %2,752 / 6,800

36.9 %2,768 / 7,507

35.3 %2,521 / 7,141

3.8 %181 / 4,741

68.4 %4,131 / 6,038

44.1 %2,952 / 6,696

5.3 %285 / 5,394

39.5 %2,943 / 7,455

3.5 %171 / 4,818



Buchnera aphidicola



Buchnera aphidicola

strain APS (endosym


)



endosymbiont of Cam

ponotus floridanus



strain BPEN endosym




endosymbiont of G

lossina brevipalpis


Ham

iltonella defensa

strain 5AT (endosym


)



strain morsitans



strain Et1/99


Erwinia carotovora



Proteus mirabilis

strain HI4320



strain 93-146


Dickeya dadantii

strain Ech703


Dickeya zeae

strain Ech1591



strain IP 31758



strain IP 32953


Yersinia pestis

strain Angola


Yersinia pestis

strain Antiqua





Shigella flexneri

2a strain 2457T


Shigella flexneri

2a strain 301




Shigella boydii

strain CDC 3083-94






Escherichia coli

strain BW2952


Escherichia coli

serotype O157:H

7 strain EC4115



strain ATCC 35469




Salmonella enterica






strain ATCC BA

A-894



strain PC1









strain NTU

H-K2044



strain 342


Citrobacter koseri

strain ATCC BA

A-895


Carso

nella r

uddii

stra

in P

V

182

prote

ins,

182

fam

ilies

Buchner

a aph

idico

la

endosy

mbio

nt of C

inar

a ce

dri

362

prote

ins,

362

fam

ilies

Buchner

a aph

idico

la

stra

in A

PS (e

ndosym

biont o

f Acy

rthosip

hon pisu

m)

567

prote

ins,

565

fam

ilies

Blochm

annia

florid

anus

endosy

mbio

nt of C

amponotu

s flo

ridan

us

583

prote

ins,

583

fam

ilies

Blochm

annia

pennsy

lvan

icus

stra

in B

PEN en

dosym

biont o

f Cam

ponotus p

ennsy

lvan

icus

610

prote

ins,

610

fam

ilies

Wig

gles

worth

ia gl

ossin

idia

endosy

mbio

nt of G

loss

ina

brevip

alpis

617

prote

ins,

617

fam

ilies

Ham

ilton

ella d

efensa

stra

in 5

AT (e

ndosym

biont o

f Acy

rthosip

hon pisu

m)

2,14

8 pro

tein

s, 1,

886

fam

ilies

Sodali

s glos

sinid

ius

stra

in m

orsita

ns

2,51

6 pro

tein

s, 2,

318

fam

ilies

Erwin

ia ta

sman

iensis

stra

in E

t1/99

3,62

2 pro

tein

s, 3,

515

fam

ilies

Erwin

ia ca

roto

vora

subsp

ecie

s atro

septic

a st

rain

SCRI1

043

4,47

2 pro

tein

s, 4,

227

fam

ilies

Proteu

s mira

bilis

stra

in H

I432

0

3,66

2 pro

tein

s, 3,

522

fam

ilies

Edwar

dsiel

la ict

aluri

stra

in 9

3-14

6

3,78

3 pro

tein

s, 3,

556

fam

ilies

Dick

eya d

adan

tii

stra

in E

ch70

3

3,97

0 pro

tein

s, 3,

785

fam

ilies

Dick

eya z

eae

stra

in E

ch15

91

4,16

4 pro

tein

s, 3,

904

fam

ilies

Yersin

ia ps

eudo

tube

rculos

is

stra

in IP

317

58

4,32

4 pro

tein

s, 4,

159

fam

ilies

Yersin

ia ps

eudo

tube

rculos

is

stra

in IP

329

53

4,03

8 pro

tein

s, 3,

858

fam

ilies

Yersin

ia pe

stis

stra

in A

ngola

4,04

0 pro

tein

s, 3,

699

fam

ilies

Yersin

ia pe

stis

stra

in A

ntiqua

4,36

4 pro

tein

s, 3,

965

fam

ilies

/Yer

sinia

enter

ocoli

tica

subsp

. ente

roco

litica

808

1

4,05

1 pro

tein

s, 3,

856

fam

ilies

Shige

lla fl

exner

i

2a st

rain

245

7T

4,06

1 pro

tein

s, 3,

449

fam

ilies

Shige

lla fl

exner

i

2a st

rain

301

4,44

0 pro

tein

s, 3,

663

fam

ilies

Shige

lla bo

ydii

stra

in S

b227

4,28

4 pro

tein

s, 3,

474

fam

ilies

Shige

lla bo

ydii

stra

in C

DC 3

083-

94

4,55

7 pro

tein

s, 3,

700

fam

ilies

Shige

lla so

nnei

stra

in S

s046

4,47

1 pro

tein

s, 3,

727

fam

ilies

Shige

lla d

ysen

teriae

stra

in S

d197

4,50

2 pro

tein

s, 3,

371

fam

ilies

Esche

richi

a coli

stra

in B

W29

52

4,08

4 pro

tein

s, 3,

817

fam

ilies

Esche

richi

a coli

sero

type O

157:

H7

stra

in E

C4115

5,47

7 pro

tein

s, 4,

686

fam

ilies

Esche

richi

a fer

guso

nii

stra

in A

TCC 354

69

4,32

1 pro

tein

s, 4,

136

fam

ilies

Salmon

ella_

enter

ica

stra

in

4,09

3 pro

tein

s, 3,

936

fam

ilies

Salmon

ella e

nterica

subsp

. ente

rica

sero

var P

arat

yphi B st

r. SP

B7

5,59

2 pro

tein

s, 5,

358

fam

ilies

Enterob

acter

spec

ies

stra

in 6

38

4,24

0 pro

tein

s, 4,

059

fam

ilies

Enterob

acter

saka

zakii

stra

in A

TCC BA

A-8

94

4,42

0 pro

tein

s, 4,

263

fam

ilies

Pecto

bacte

rium

caro

tovo

rum

stra

in P

C1

4,24

6 pro

tein

s, 4,

038

fam

ilies

Photo

rhab

dus a

sym

biotic

a

stra

in A

TCC 439

49 (s

ymbio

nt of H

eter

orhab

ditis i

ndica)

4,41

7 pro

tein

s, 3,

856

fam

ilies

Serra

tia p

rotea

mac

ulans

stra

in 5

68

4,94

2 pro

tein

s, 4,

637

fam

ilies

Klebsie

lla p

neum

oniae

stra

in N

TUH

-K20

44

4,99

2 pro

tein

s, 4,

741

fam

ilies

Klebsie

lla p

neum

oniae

stra

in 3

42

5,76

8 pro

tein

s, 5,

394

fam

ilies

Citrob

acter

kose

ri

stra

in A

TCC BA

A-8

95

5,03

1 pro

tein

s, 4,

818

fam

ilies


20.0 %0.0 %


100.0 %0.0 %



epartment of S

ystems B


enmark

3.0 %

110 / 3,665

88.1 %

3,495 / 3,966

80.4 %

3,303 / 4,109

77.1 %

3,186 / 4,134

92.9 %

3,489 / 3,754

79.6 %

3,139 / 3,944

85.8 %

3,291 / 3,837

83.2 %

3,325 / 3,995

82.4 %

3,302 / 4,009

83.4 %

3,315 / 3,973

76.9 %

3,165 / 4,117

64.7 %

2,888 / 4,463

70.4 %

2,922 / 4,153

68.7 %

2,874 / 4,181

75.9 %

3,094 / 4,077

71.6 %

3,010 / 4,205

73.6 %

3,045 / 4,135

70.3 %

2,933 / 4,174

40.0 %

2,421 / 6,055

42.2 %

2,215 / 5,254

44.3 %

2,515 / 5,683

41.7 %

2,552 / 6,116

38.4 %

2,291 / 5,971

40.3 %

2,326 / 5,771

35.0 %

1,949 / 5,561

34.0 %

1,963 / 5,771

32.1 %

1,846 / 5,747

38.7 %

2,143 / 5,536

35.8 %

2,018 / 5,637

32.5 %

2,385 / 7,336

31.2 %

2,143 / 6,862

27.2 %

1,946 / 7,165

4.2 %

155 / 3,729

88.8 %

3,489 / 3,927

74.9 %

3,187 / 4,253

89.7 %

3,485 / 3,884

78.1 %

3,147 / 4,032

82.5 %

3,278 / 3,971

80.7 %

3,321 / 4,117

80.8 %

3,319 / 4,106

81.3 %

3,320 / 4,085

76.7 %

3,195 / 4,167

64.9 %

2,940 / 4,533

70.3 %

2,965 / 4,217

67.2 %

2,880 / 4,288

77.2 %

3,155 / 4,088

72.6 %

3,068 / 4,226

74.9 %

3,101 / 4,142

69.2 %

2,953 / 4,267

39.6 %

2,438 / 6,154

41.6 %

2,225 / 5,354

43.7 %

2,527 / 5,781

41.2 %

2,564 / 6,224

38.0 %

2,307 / 6,067

39.8 %

2,339 / 5,873

34.8 %

1,967 / 5,647

33.7 %

1,977 / 5,865

32.1 %

1,873 / 5,828

38.3 %

2,156 / 5,631

35.9 %

2,049 / 5,713

32.6 %

2,405 / 7,380

31.1 %

2,163 / 6,948

27.1 %

1,964 / 7,245

4.3 %

157 / 3,665

80.2 %

3,271 / 4,079

81.1 %

3,280 / 4,046

80.2 %

3,169 / 3,953

83.4 %

3,267 / 3,919

81.4 %

3,309 / 4,067

81.6 %

3,311 / 4,057

81.9 %

3,311 / 4,041

81.6 %

3,264 / 4,000

67.6 %

2,983 / 4,413

72.2 %

2,986 / 4,136

69.7 %

2,916 / 4,183

78.0 %

3,149 / 4,038

73.5 %

3,065 / 4,172

75.5 %

3,089 / 4,092

69.7 %

2,944 / 4,221

40.0 %

2,440 / 6,094

42.3 %

2,236 / 5,283

44.5 %

2,539 / 5,707

41.9 %

2,575 / 6,151

38.5 %

2,311 / 6,004

40.4 %

2,345 / 5,808

35.3 %

1,972 / 5,581

34.2 %

1,983 / 5,797

32.5 %

1,873 / 5,769

38.8 %

2,162 / 5,566

36.4 %

2,055 / 5,647

33.1 %

2,415 / 7,299

31.5 %

2,169 / 6,884

27.5 %

1,971 / 7,179

3.3 %

120 / 3,599

77.3 %

3,164 / 4,093

75.1 %

3,024 / 4,028

79.4 %

3,143 / 3,956

76.0 %

3,147 / 4,141

75.3 %

3,136 / 4,162

76.3 %

3,142 / 4,120

77.5 %

3,153 / 4,066

65.1 %

2,880 / 4,423

68.5 %

2,869 / 4,191

69.0 %

2,860 / 4,145

71.5 %

2,986 / 4,175

68.5 %

2,914 / 4,256

69.8 %

2,942 / 4,217

66.3 %

2,833 / 4,271

38.4 %

2,348 / 6,120

41.3 %

2,181 / 5,277

42.8 %

2,449 / 5,718

40.0 %

2,473 / 6,185

37.0 %

2,227 / 6,026

38.6 %

2,251 / 5,839

33.6 %

1,884 / 5,612

32.5 %

1,896 / 5,827

30.6 %

1,777 / 5,804

37.9 %

2,110 / 5,560

34.7 %

1,968 / 5,677

31.7 %

2,323 / 7,337

30.4 %

2,098 / 6,893

26.3 %

1,893 / 7,208

2.8 %

99 / 3,560

80.7 %

3,108 / 3,853

87.0 %

3,272 / 3,762

82.9 %

3,277 / 3,954

82.6 %

3,267 / 3,954

83.7 %

3,275 / 3,915

78.4 %

3,157 / 4,029

67.3 %

2,909 / 4,320

73.7 %

2,947 / 4,001

71.8 %

2,896 / 4,036

79.5 %

3,125 / 3,932

74.1 %

3,024 / 4,083

76.0 %

3,059 / 4,025

73.2 %

2,952 / 4,034

41.4 %

2,445 / 5,905

43.8 %

2,234 / 5,101

45.9 %

2,535 / 5,526

42.9 %

2,564 / 5,977

39.7 %

2,312 / 5,825

41.7 %

2,346 / 5,626

36.3 %

1,965 / 5,413

35.3 %

1,981 / 5,619

33.3 %

1,863 / 5,593

40.3 %

2,167 / 5,378

37.3 %

2,045 / 5,477

33.6 %

2,410 / 7,181

32.3 %

2,164 / 6,706

28.0 %

1,962 / 7,016

1.8 %

59 / 3,353

83.0 %

3,126 / 3,768

83.2 %

3,208 / 3,855

85.6 %

3,244 / 3,790

86.6 %

3,253 / 3,757

74.3 %

2,987 / 4,018

67.8 %

2,836 / 4,184

81.0 %

2,989 / 3,688

71.5 %

2,801 / 3,915

77.9 %

3,002 / 3,856

73.0 %

2,908 / 3,986

75.2 %

2,954 / 3,928

73.5 %

2,863 / 3,897

42.4 %

2,408 / 5,683

45.9 %

2,223 / 4,842

47.1 %

2,503 / 5,310

44.1 %

2,533 / 5,743

40.6 %

2,270 / 5,592

42.9 %

2,314 / 5,388

37.7 %

1,947 / 5,165

36.6 %

1,964 / 5,371

34.4 %

1,846 / 5,360

41.6 %

2,140 / 5,139

38.7 %

2,021 / 5,225

34.3 %

2,377 / 6,932

33.0 %

2,137 / 6,467

28.7 %

1,944 / 6,766

2.9 %

100 / 3,429

91.4 %

3,373 / 3,689

90.1 %

3,346 / 3,715

91.2 %

3,355 / 3,679

78.6 %

3,113 / 3,962

68.1 %

2,876 / 4,226

74.9 %

2,944 / 3,932

72.2 %

2,861 / 3,960

83.0 %

3,135 / 3,777

78.5 %

3,061 / 3,901

80.4 %

3,080 / 3,831

76.4 %

2,970 / 3,887

41.8 %

2,434 / 5,818

44.3 %

2,232 / 5,038

46.4 %

2,534 / 5,464

43.3 %

2,559 / 5,916

39.9 %

2,299 / 5,768

41.9 %

2,334 / 5,571

36.6 %

1,961 / 5,354

35.5 %

1,974 / 5,563

33.4 %

1,852 / 5,547

40.6 %

2,159 / 5,323

37.4 %

2,032 / 5,428

33.8 %

2,403 / 7,116

32.4 %

2,155 / 6,649

28.2 %

1,960 / 6,957

2.8 %

102 / 3,619

90.4 %

3,439 / 3,805

91.7 %

3,455 / 3,766

75.5 %

3,125 / 4,141

66.4 %

2,917 / 4,393

73.3 %

2,983 / 4,071

69.0 %

2,868 / 4,158

79.4 %

3,144 / 3,961

75.8 %

3,073 / 4,056

77.3 %

3,098 / 4,009

73.1 %

2,977 / 4,072

40.8 %

2,445 / 5,993

43.0 %

2,240 / 5,212

45.2 %

2,546 / 5,633

42.3 %

2,572 / 6,075

38.9 %

2,309 / 5,932

40.9 %

2,343 / 5,733

35.7 %

1,969 / 5,522

34.6 %

1,982 / 5,732

32.7 %

1,868 / 5,705

39.5 %

2,169 / 5,493

36.7 %

2,048 / 5,585

33.3 %

2,418 / 7,252

31.8 %

2,169 / 6,817

27.6 %

1,965 / 7,122

3.0 %

109 / 3,575

96.0 %

3,531 / 3,678

74.6 %

3,103 / 4,160

66.3 %

2,908 / 4,386

73.6 %

2,979 / 4,045

69.1 %

2,864 / 4,145

79.3 %

3,138 / 3,958

75.1 %

3,061 / 4,077

77.1 %

3,088 / 4,007

73.4 %

2,971 / 4,050

41.1 %

2,450 / 5,957

43.4 %

2,242 / 5,171

45.5 %

2,548 / 5,599

42.7 %

2,578 / 6,032

39.3 %

2,314 / 5,892

41.2 %

2,346 / 5,697

35.9 %

1,971 / 5,485

34.8 %

1,984 / 5,694

33.0 %

1,872 / 5,667

39.7 %

2,168 / 5,459

37.0 %

2,051 / 5,545

33.5 %

2,420 / 7,225

32.1 %

2,173 / 6,778

27.7 %

1,965 / 7,093

2.6 %

92 / 3,593

75.4 %

3,111 / 4,124

67.0 %

2,915 / 4,348

74.3 %

2,982 / 4,014

70.0 %

2,873 / 4,102

80.3 %

3,147 / 3,918

76.3 %

3,076 / 4,029

78.0 %

3,097 / 3,971

73.8 %

2,975 / 4,030

41.3 %

2,449 / 5,936

43.6 %

2,244 / 5,143

45.8 %

2,552 / 5,568

42.9 %

2,579 / 6,005

39.4 %

2,314 / 5,868

41.4 %

2,346 / 5,670

36.1 %

1,971 / 5,458

35.0 %

1,985 / 5,667

33.2 %

1,872 / 5,641

40.0 %

2,171 / 5,428

37.2 %

2,052 / 5,516

33.6 %

2,420 / 7,193

32.2 %

2,173 / 6,752

27.8 %

1,967 / 7,064

3.5 %

125 / 3,567

64.7 %

2,847 / 4,403

68.5 %

2,844 / 4,150

68.3 %

2,820 / 4,126

73.1 %

3,000 / 4,103

69.2 %

2,925 / 4,226

71.3 %

2,953 / 4,142

65.6 %

2,791 / 4,256

37.9 %

2,313 / 6,099

41.1 %

2,153 / 5,242

42.2 %

2,409 / 5,711

39.4 %

2,432 / 6,172

36.9 %

2,208 / 5,989

38.0 %

2,213 / 5,823

32.8 %

1,843 / 5,611

31.9 %

1,857 / 5,817

30.2 %

1,747 / 5,786

38.2 %

2,104 / 5,504

34.4 %

1,944 / 5,645

31.0 %

2,282 / 7,362

30.3 %

2,079 / 6,856

25.7 %

1,850 / 7,198

2.8 %

99 / 3,586

70.6 %

2,886 / 4,087

68.0 %

2,806 / 4,126

69.5 %

2,908 / 4,185

64.3 %

2,805 / 4,365

70.2 %

2,930 / 4,172

65.2 %

2,768 / 4,246

38.2 %

2,320 / 6,080

41.2 %

2,152 / 5,228

41.4 %

2,372 / 5,735

39.1 %

2,413 / 6,176

36.4 %

2,186 / 6,003

38.0 %

2,209 / 5,811

33.1 %

1,848 / 5,585

32.1 %

1,861 / 5,795

30.0 %

1,736 / 5,791

37.3 %

2,064 / 5,537

34.8 %

1,952 / 5,606

30.8 %

2,270 / 7,379

29.7 %

2,044 / 6,887

25.6 %

1,841 / 7,194

2.5 %

84 / 3,305

73.1 %

2,818 / 3,854

76.7 %

2,961 / 3,861

71.6 %

2,868 / 4,006

77.2 %

2,983 / 3,866

71.6 %

2,802 / 3,915

42.3 %

2,399 / 5,675

46.0 %

2,220 / 4,821

46.3 %

2,464 / 5,326

43.0 %

2,483 / 5,781

39.9 %

2,238 / 5,609

41.8 %

2,264 / 5,418

36.7 %

1,906 / 5,192

35.6 %

1,922 / 5,398

33.6 %

1,805 / 5,377

41.6 %

2,134 / 5,135

38.1 %

1,994 / 5,228

33.3 %

2,327 / 6,984

32.4 %

2,098 / 6,481

28.1 %

1,904 / 6,782

2.2 %

73 / 3,311

71.8 %

2,849 / 3,968

67.9 %

2,780 / 4,092

71.8 %

2,855 / 3,974

68.6 %

2,743 / 4,001

39.7 %

2,303 / 5,796

42.7 %

2,113 / 4,953

43.5 %

2,367 / 5,437

40.1 %

2,373 / 5,919

38.0 %

2,171 / 5,707

39.9 %

2,202 / 5,514

34.9 %

1,843 / 5,282

34.2 %

1,872 / 5,473

31.9 %

1,743 / 5,469

39.1 %

2,048 / 5,244

36.4 %

1,935 / 5,317

32.1 %

2,268 / 7,062

31.2 %

2,045 / 6,565

26.9 %

1,851 / 6,869

2.1 %

72 / 3,454

78.6 %

3,059 / 3,894

82.5 %

3,117 / 3,780

77.1 %

2,975 / 3,861

42.9 %

2,463 / 5,745

44.3 %

2,213 / 5,001

45.9 %

2,501 / 5,451

43.5 %

2,550 / 5,859

40.1 %

2,293 / 5,719

42.0 %

2,320 / 5,530

36.8 %

1,951 / 5,307

35.7 %

1,970 / 5,513

33.5 %

1,845 / 5,501

40.4 %

2,139 / 5,293

37.7 %

2,026 / 5,367

34.2 %

2,394 / 7,002

32.6 %

2,153 / 6,600

28.2 %

1,949 / 6,915

2.4 %

83 / 3,442

78.0 %

3,045 / 3,906

73.0 %

2,911 / 3,989

40.8 %

2,400 / 5,876

43.5 %

2,200 / 5,058

46.1 %

2,513 / 5,455

42.2 %

2,506 / 5,941

39.2 %

2,272 / 5,796

41.1 %

2,303 / 5,603

36.1 %

1,940 / 5,373

34.9 %

1,952 / 5,586

32.9 %

1,824 / 5,545

39.4 %

2,118 / 5,370

37.3 %

2,022 / 5,418

33.4 %

2,359 / 7,060

31.8 %

2,123 / 6,682

27.9 %

1,942 / 6,969

2.9 %

99 / 3,427

74.7 %

2,922 / 3,914

42.4 %

2,451 / 5,781

44.9 %

2,242 / 4,998

45.7 %

2,506 / 5,480

42.9 %

2,536 / 5,906

39.8 %

2,292 / 5,756

41.6 %

2,314 / 5,569

36.2 %

1,940 / 5,352

35.2 %

1,954 / 5,558

33.0 %

1,831 / 5,549

40.3 %

2,145 / 5,320

37.3 %

2,019 / 5,407

33.4 %

2,375 / 7,115

32.0 %

2,130 / 6,656

27.9 %

1,941 / 6,954

1.9 %

62 / 3,316

40.9 %

2,360 / 5,769

43.5 %

2,155 / 4,958

45.1 %

2,444 / 5,415

42.3 %

2,475 / 5,845

39.2 %

2,230 / 5,684

41.5 %

2,272 / 5,479

36.3 %

1,906 / 5,250

35.3 %

1,926 / 5,455

33.1 %

1,804 / 5,448

39.8 %

2,086 / 5,245

37.8 %

2,001 / 5,288

33.0 %

2,325 / 7,056

32.0 %

2,097 / 6,549

27.9 %

1,909 / 6,851

3.2 %

147 / 4,662

43.5 %

2,547 / 5,858

48.9 %

2,994 / 6,128

46.4 %

3,042 / 6,550

41.4 %

2,698 / 6,523

43.9 %

2,762 / 6,293

35.9 %

2,233 / 6,219

35.5 %

2,270 / 6,400

31.9 %

2,074 / 6,494

64.9 %

3,384 / 5,214

47.0 %

2,741 / 5,827

46.4 %

3,371 / 7,266

35.2 %

2,581 / 7,333

29.6 %

2,295 / 7,753

2.1 %

79 / 3,683

47.2 %

2,608 / 5,524

43.2 %

2,597 / 6,013

43.7 %

2,492 / 5,705

45.4 %

2,507 / 5,523

36.2 %

1,976 / 5,464

34.5 %

1,965 / 5,696

32.3 %

1,842 / 5,705

45.0 %

2,357 / 5,232

37.8 %

2,081 / 5,503

34.9 %

2,496 / 7,160

34.3 %

2,276 / 6,634

27.9 %

1,972 / 7,061

2.8 %

121 / 4,337

67.5 %

3,741 / 5,540

41.9 %

2,637 / 6,301

43.7 %

2,670 / 6,112

36.3 %

2,179 / 6,005

35.3 %

2,191 / 6,211

32.6 %

2,040 / 6,250

46.1 %

2,626 / 5,697

39.9 %

2,372 / 5,942

38.7 %

2,880 / 7,439

34.4 %

2,472 / 7,184

29.4 %

2,212 / 7,534

3.1 %

150 / 4,773

39.7 %

2,672 / 6,728

40.8 %

2,680 / 6,565

34.2 %

2,205 / 6,448

33.1 %

2,209 / 6,672

30.5 %

2,050 / 6,715

43.2 %

2,655 / 6,143

37.5 %

2,396 / 6,387

37.0 %

2,900 / 7,832

33.0 %

2,516 / 7,615

27.8 %

2,222 / 7,979

2.3 %

103 / 4,463

72.3 %

3,688 / 5,101

36.6 %

2,201 / 6,016

35.7 %

2,219 / 6,213

33.1 %

2,074 / 6,269

40.2 %

2,413 / 5,999

36.9 %

2,259 / 6,124

34.6 %

2,682 / 7,762

36.5 %

2,593 / 7,105

28.1 %

2,155 / 7,667

2.8 %

118 / 4,277

38.7 %

2,246 / 5,808

38.1 %

2,277 / 5,979

34.9 %

2,114 / 6,065

42.3 %

2,451 / 5,795

38.6 %

2,289 / 5,931

36.7 %

2,759 / 7,516

36.7 %

2,562 / 6,982

29.5 %

2,198 / 7,456

2.6 %

96 / 3,691

75.0 %

3,261 / 4,346

55.5 %

2,683 / 4,838

34.5 %

1,963 / 5,692

33.6 %

1,915 / 5,695

29.6 %

2,214 / 7,478

30.4 %

2,085 / 6,866

30.3 %

2,110 / 6,968

2.9 %

112 / 3,894

52.4 %

2,666 / 5,085

33.9 %

1,991 / 5,874

32.5 %

1,919 / 5,903

29.3 %

2,244 / 7,665

29.4 %

2,083 / 7,082

29.7 %

2,127 / 7,169

3.3 %

111 / 3,378

30.5 %

1,813 / 5,939

30.3 %

1,795 / 5,923

28.3 %

2,095 / 7,406

26.7 %

1,916 / 7,168

28.3 %

1,980 / 6,989

2.7 %

103 / 3,886

46.2 %

2,452 / 5,307

43.4 %

2,981 / 6,875

34.5 %

2,335 / 6,762

28.0 %

2,022 / 7,222

2.3 %

88 / 3,822

45.0 %

3,018 / 6,702

30.9 %

2,144 / 6,948

25.5 %

1,872 / 7,339

3.9 %

201 / 5,117

30.1 %

2,581 / 8,574

26.1 %

2,254 / 8,624

3.9 %

200 / 5,078

25.9 %

2,170 / 8,370

5.0 %

243 / 4,897

V.cholerae

N16961

V.cholerae

0395 TEDA

V.cholerae

0395 TIGR

V.cholerae

V52

V.cholerae

M66-2M

O10

V.cholerae

BX330286

V.cholerae

RC9

V.cholerae

MJ1236

V.cholerae

B33V

CE

V.cholerae

2740-80

V.cholerae

V.cholerae

1587

V.cholerae

AM

-19226

V.cholerae

MZO

-2

V.cholerae

12129

V.choleraeTM

11079-80

V.cholerae

TMA21

V.cholerae

VL426

V.parahaem

olyticus2210633

V.parahaem

olyticus16

V.vulnificus

CM

CP6

V.vulnificus

YJ016

V.species

MED222

V.splendidus

LGP32

A.fischeri E

S114

A.fischeri M

J11

A.salm

onicidaLFI1238

V.species

Ex25

V.cam

pbellii AND4

V.harveyi B

AA1116

V.shilonii A

K1

P.profundum

SS9 V

.cho

lera

eN16

961

V.cho

lera

e03

95 T

EDA

V.cho

lera

e03

95 T

IGR

V.cho

lera

eV52

V.cho

lera

eM

66-2

V.cho

lera

eM

O10

V.cho

lera

eBX33

0286

V.cho

lera

eRC9

V.cho

lera

eM

J123

6

V.cho

lera

eB33

VCE

V.cho

lera

e27

40-8

0

V.cho

lera

e15

87

V.cho

lera

eAM

-192

26

V.cho

lera

eM

ZO-2

V.cho

lera

e12

129

V.cho

lera

eTM

1107

9-80

V.cho

lera

eTM

A21

V.cho

lera

eVL4

26

V.p

arah

aem

olyticus

221

0633

V.p

arah

aem

olyticus

16

V.vulnific

usCM

CP6

V.vulnific

usYJ0

16

V.spe

cies

MED22

2

V.splen

didu

sLG

P32

A.fisc

heri

ES11

4

A.fisc

heri

MJ1

1

A.salm

onicida

LFI1

238

V.spe

cies

Ex2

5

V.cam

pbellii

AND4

V.h

arve

yiBAA11

16

V.shilonii A

K1

P.p

rofu

ndum

SS9


6.0 %0.0 %


90.0 %30.0 %

34 Vibrio genomes



epartment of S

ystems B


enmark

4.2 %166 / 3,912

2.6 %235 / 9,140

1.8 %151 / 8,465

1.5 %172 / 11,197

1.4 %114 / 7,928

1.4 %108 / 7,945

1.8 %133 / 7,193

1.8 %135 / 7,379

1.8 %144 / 7,874

2.0 %153 / 7,710

2.1 %140 / 6,772

2.1 %130 / 6,270

1.5 %108 / 7,166

1.5 %96 / 6,495

1.6 %129 / 7,967

1.6 %129 / 7,983

1.4 %115 / 8,247

1.8 %144 / 7,810

2.2 %140 / 6,311

1.8 %119 / 6,583

2.0 %129 / 6,375

1.8 %116 / 6,451

1.5 %156 / 10,360

2.3 %158 / 6,750

2.5 %169 / 6,825

2.5 %168 / 6,680

2.2 %158 / 7,072

2.2 %159 / 7,265

2.0 %149 / 7,324

2.1 %158 / 7,554

2.3 %150 / 6,558

1.9 %148 / 7,660

2.0 %147 / 7,233

2.0 %153 / 7,493

2.2 %196 / 8,907

2.0 %154 / 7,786

2.1 %170 / 8,243

1.6 %125 / 7,910

1.7 %125 / 7,519

1.9 %147 / 7,821

1.9 %145 / 7,632

1.9 %147 / 7,639

1.9 %146 / 7,849

2.0 %146 / 7,377

2.0 %147 / 7,523

1.9 %147 / 7,564

1.9 %146 / 7,740

1.8 %145 / 7,960

1.9 %151 / 8,066

1.9 %147 / 7,781

5.2 %258 / 4,930

4.5 %421 / 9,266

2.6 %312 / 12,129

2.8 %248 / 8,909

2.7 %241 / 8,919

4.3 %343 / 8,065

4.0 %327 / 8,278

3.7 %325 / 8,782

4.8 %405 / 8,517

4.5 %348 / 7,657

4.0 %288 / 7,226

4.1 %327 / 8,054

3.9 %291 / 7,406

3.1 %272 / 8,914

3.2 %289 / 8,921

3.1 %287 / 9,174

5.1 %434 / 8,563

5.3 %377 / 7,164

4.6 %344 / 7,451

4.8 %347 / 7,252

4.6 %338 / 7,312

2.3 %265 / 11,338

5.0 %383 / 7,610

5.2 %396 / 7,682

5.2 %391 / 7,537

4.8 %381 / 7,932

4.6 %378 / 8,131

4.6 %375 / 8,183

4.4 %369 / 8,432

5.0 %373 / 7,415

4.7 %400 / 8,487

5.0 %403 / 8,056

4.8 %400 / 8,315

4.8 %463 / 9,673

4.3 %368 / 8,632

4.4 %400 / 9,064

4.6 %400 / 8,706

4.8 %398 / 8,315

5.3 %453 / 8,561

5.4 %449 / 8,375

5.3 %443 / 8,387

5.2 %449 / 8,600

5.3 %435 / 8,136

5.4 %443 / 8,272

5.3 %441 / 8,313

5.4 %456 / 8,474

5.1 %446 / 8,707

5.0 %445 / 8,815

5.0 %430 / 8,551

4.8 %203 / 4,240

4.1 %462 / 11,188

4.6 %370 / 7,977

4.4 %355 / 8,029

8.3 %583 / 6,995

8.3 %597 / 7,185

7.2 %561 / 7,744

7.4 %561 / 7,573

7.9 %531 / 6,685

6.5 %411 / 6,322

4.4 %323 / 7,270

4.4 %289 / 6,598

5.5 %441 / 7,946

5.6 %447 / 7,961

5.2 %426 / 8,240

15.2 %1,077 / 7,103

14.7 %867 / 5,893

12.3 %769 / 6,243

12.9 %777 / 6,038

11.9 %728 / 6,137

4.0 %414 / 10,403

12.5 %802 / 6,411

12.9 %836 / 6,461

12.8 %814 / 6,335

11.9 %798 / 6,727

11.6 %803 / 6,917

11.1 %775 / 6,979

11.1 %799 / 7,199

12.9 %803 / 6,201

12.7 %905 / 7,150

13.4 %899 / 6,726

13.0 %909 / 6,985

14.5 %1,168 / 8,053

13.2 %951 / 7,215

13.6 %1,035 / 7,586

13.1 %955 / 7,314

13.6 %944 / 6,941

13.3 %965 / 7,233

13.6 %955 / 7,046

13.6 %960 / 7,056

13.4 %969 / 7,254

13.8 %945 / 6,824

13.7 %955 / 6,959

13.6 %952 / 7,001

13.7 %978 / 7,133

13.0 %962 / 7,374

12.7 %952 / 7,500

12.9 %933 / 7,231

4.4 %301 / 6,843

4.9 %511 / 10,515

4.9 %518 / 10,570

4.9 %482 / 9,873

4.8 %486 / 10,047

9.3 %938 / 10,072

5.4 %554 / 10,244

4.9 %462 / 9,500

4.7 %422 / 9,057

4.4 %438 / 9,918

3.9 %360 / 9,289

11.5 %1,138 / 9,883

11.6 %1,145 / 9,859

10.2 %1,036 / 10,204

4.3 %453 / 10,557

4.6 %417 / 9,112

4.0 %380 / 9,414

4.2 %384 / 9,195

3.6 %339 / 9,317

20.2 %2,226 / 11,016

4.3 %415 / 9,567

4.5 %432 / 9,641

4.5 %423 / 9,499

4.2 %414 / 9,862

4.2 %424 / 10,067

4.0 %406 / 10,132

4.0 %410 / 10,375

4.3 %399 / 9,383

4.4 %457 / 10,392

4.6 %461 / 9,967

4.5 %460 / 10,237

4.7 %548 / 11,563

5.1 %534 / 10,439

5.6 %607 / 10,823

4.2 %442 / 10,607

4.2 %431 / 10,237

4.4 %461 / 10,544

4.6 %471 / 10,347

4.5 %463 / 10,362

4.4 %466 / 10,572

4.5 %460 / 10,112

4.5 %460 / 10,255

4.5 %462 / 10,294

4.4 %464 / 10,451

4.3 %456 / 10,693

4.2 %454 / 10,807

4.2 %439 / 10,536

2.8 %105 / 3,737

10.4 %734 / 7,030

6.4 %427 / 6,625

6.2 %421 / 6,801

5.7 %418 / 7,341

5.8 %415 / 7,138

5.7 %360 / 6,290

4.9 %288 / 5,867

4.7 %312 / 6,707

4.7 %281 / 6,043

6.5 %479 / 7,336

6.2 %458 / 7,341

6.2 %471 / 7,540

4.6 %340 / 7,365

5.3 %313 / 5,899

4.8 %297 / 6,166

4.6 %274 / 5,974

4.2 %256 / 6,056

4.5 %440 / 9,802

5.2 %327 / 6,326

5.2 %336 / 6,416

5.3 %331 / 6,258

4.8 %321 / 6,631

4.8 %332 / 6,849

4.6 %316 / 6,889

4.4 %316 / 7,152

5.1 %312 / 6,135

5.0 %360 / 7,183

5.3 %360 / 6,751

5.2 %362 / 6,996

4.6 %389 / 8,445

5.1 %371 / 7,297

5.3 %411 / 7,723

5.1 %375 / 7,378

5.3 %368 / 6,995

4.7 %343 / 7,371

4.8 %344 / 7,172

4.7 %335 / 7,195

4.6 %340 / 7,399

4.8 %334 / 6,938

4.7 %335 / 7,083

4.8 %339 / 7,120

4.7 %342 / 7,280

4.6 %342 / 7,507

4.5 %340 / 7,620

4.5 %327 / 7,345

4.0 %151 / 3,756

6.5 %431 / 6,650

6.3 %432 / 6,829

5.9 %432 / 7,352

5.1 %371 / 7,235

5.2 %330 / 6,346

4.7 %275 / 5,907

4.3 %294 / 6,773

4.5 %276 / 6,094

6.5 %478 / 7,349

6.9 %502 / 7,325

7.0 %522 / 7,483

4.5 %331 / 7,405

5.5 %322 / 5,907

4.7 %293 / 6,190

4.7 %281 / 6,007

4.0 %241 / 6,092

4.7 %458 / 9,806

4.7 %303 / 6,384

4.9 %319 / 6,452

4.9 %311 / 6,314

4.4 %294 / 6,713

4.3 %300 / 6,902

4.2 %290 / 6,957

4.1 %294 / 7,193

4.8 %297 / 6,180

4.9 %356 / 7,217

5.2 %351 / 6,790

4.9 %343 / 7,068

4.5 %381 / 8,478

4.7 %348 / 7,351

4.9 %381 / 7,785

4.4 %330 / 7,462

4.6 %326 / 7,079

4.3 %319 / 7,424

4.4 %316 / 7,235

4.3 %315 / 7,245

4.3 %322 / 7,449

4.5 %314 / 6,987

4.4 %315 / 7,134

4.5 %320 / 7,167

4.5 %330 / 7,329

4.1 %311 / 7,564

4.1 %318 / 7,672

4.1 %302 / 7,402

3.6 %105 / 2,933

18.3 %999 / 5,448

7.9 %517 / 6,522

7.2 %462 / 6,419

8.0 %438 / 5,495

7.2 %365 / 5,065

4.3 %261 / 6,071

4.5 %240 / 5,361

6.6 %442 / 6,674

6.9 %459 / 6,663

6.2 %433 / 6,929

8.2 %526 / 6,439

10.1 %500 / 4,970

8.3 %441 / 5,293

8.8 %446 / 5,088

7.9 %411 / 5,172

4.6 %421 / 9,113

7.8 %428 / 5,520

7.8 %439 / 5,597

8.2 %445 / 5,439

7.4 %427 / 5,782

7.0 %423 / 6,021

6.8 %413 / 6,060

6.6 %418 / 6,325

8.1 %428 / 5,264

7.6 %483 / 6,336

8.2 %482 / 5,913

7.8 %481 / 6,181

7.0 %527 / 7,554

7.1 %459 / 6,481

7.2 %498 / 6,912

9.2 %588 / 6,416

9.7 %586 / 6,032

8.2 %526 / 6,450

8.3 %519 / 6,261

8.3 %518 / 6,273

8.1 %526 / 6,476

8.6 %516 / 6,014

8.4 %519 / 6,157

8.5 %524 / 6,190

8.3 %529 / 6,357

7.9 %521 / 6,591

7.8 %520 / 6,703

7.8 %501 / 6,432

4.3 %136 / 3,146

7.8 %522 / 6,707

6.5 %431 / 6,653

7.2 %409 / 5,720

6.7 %354 / 5,281

4.2 %263 / 6,255

4.3 %239 / 5,582

6.3 %433 / 6,870

6.6 %450 / 6,855

5.9 %423 / 7,143

8.0 %531 / 6,609

9.2 %477 / 5,196

7.6 %419 / 5,508

7.7 %411 / 5,304

7.0 %376 / 5,407

4.4 %409 / 9,331

7.5 %427 / 5,696

7.8 %449 / 5,763

7.8 %440 / 5,619

7.1 %424 / 5,996

6.8 %421 / 6,222

6.5 %409 / 6,270

6.3 %412 / 6,523

7.9 %431 / 5,482

7.6 %495 / 6,509

8.1 %493 / 6,084

7.5 %478 / 6,358

7.2 %555 / 7,723

7.0 %468 / 6,664

7.2 %507 / 7,084

8.7 %575 / 6,627

9.0 %562 / 6,246

7.6 %509 / 6,661

8.0 %517 / 6,455

8.0 %515 / 6,475

7.8 %518 / 6,673

8.1 %502 / 6,223

8.0 %509 / 6,364

8.0 %511 / 6,403

8.1 %530 / 6,554

7.6 %519 / 6,788

7.4 %510 / 6,910

7.6 %501 / 6,633

3.0 %112 / 3,756

6.5 %462 / 7,099

7.0 %432 / 6,198

5.9 %339 / 5,790

5.7 %377 / 6,645

5.5 %330 / 5,986

12.4 %857 / 6,933

12.1 %841 / 6,965

11.8 %848 / 7,207

6.9 %492 / 7,165

7.4 %426 / 5,757

6.5 %393 / 6,044

6.8 %395 / 5,835

6.0 %355 / 5,930

9.5 %886 / 9,283

6.9 %428 / 6,197

7.1 %445 / 6,263

7.1 %435 / 6,124

6.6 %427 / 6,514

6.3 %424 / 6,710

6.1 %410 / 6,755

6.0 %417 / 7,007

6.8 %407 / 6,017

7.2 %507 / 7,009

7.6 %498 / 6,589

7.3 %501 / 6,851

7.1 %578 / 8,181

7.2 %515 / 7,117

7.5 %567 / 7,522

5.7 %420 / 7,327

6.0 %417 / 6,938

7.1 %506 / 7,152

7.4 %514 / 6,951

7.2 %505 / 6,978

7.0 %506 / 7,184

7.4 %496 / 6,728

7.3 %499 / 6,870

7.3 %506 / 6,905

7.2 %510 / 7,068

7.0 %507 / 7,292

6.7 %500 / 7,409

6.9 %490 / 7,134

7.2 %244 / 3,402

24.7 %1,259 / 5,098

21.8 %1,054 / 4,837

5.4 %350 / 6,459

5.0 %291 / 5,865

6.9 %492 / 7,130

7.3 %516 / 7,096

6.9 %500 / 7,271

8.5 %582 / 6,878

10.3 %563 / 5,442

9.4 %536 / 5,700

9.7 %533 / 5,511

8.8 %494 / 5,586

5.0 %481 / 9,537

10.2 %596 / 5,857

10.4 %615 / 5,929

10.5 %607 / 5,777

9.5 %587 / 6,176

9.6 %606 / 6,331

9.1 %582 / 6,414

8.7 %583 / 6,671

10.2 %578 / 5,673

10.1 %669 / 6,651

10.6 %661 / 6,228

10.4 %675 / 6,474

8.8 %692 / 7,862

9.2 %623 / 6,799

9.5 %684 / 7,193

8.6 %599 / 6,929

9.1 %594 / 6,549

10.5 %707 / 6,706

11.0 %717 / 6,498

11.0 %714 / 6,516

10.6 %716 / 6,726

11.1 %698 / 6,281

11.0 %705 / 6,421

11.0 %707 / 6,456

11.2 %738 / 6,570

10.4 %713 / 6,837

10.3 %714 / 6,942

10.3 %692 / 6,687

2.9 %77 / 2,690

19.8 %825 / 4,170

5.6 %314 / 5,585

5.8 %287 / 4,921

6.9 %433 / 6,264

6.9 %434 / 6,278

6.9 %445 / 6,479

8.5 %514 / 6,051

11.6 %527 / 4,532

9.9 %480 / 4,840

10.4 %483 / 4,640

9.0 %428 / 4,735

4.6 %398 / 8,743

11.4 %566 / 4,947

11.4 %573 / 5,034

11.9 %580 / 4,872

10.8 %569 / 5,253

10.4 %566 / 5,456

10.2 %559 / 5,502

9.5 %549 / 5,755

11.9 %566 / 4,742

10.2 %592 / 5,804

10.9 %589 / 5,385

10.2 %577 / 5,662

8.8 %622 / 7,058

10.1 %599 / 5,917

10.5 %664 / 6,302

8.5 %518 / 6,122

9.0 %515 / 5,733

9.3 %557 / 5,999

9.7 %560 / 5,801

9.8 %567 / 5,795

9.4 %564 / 6,013

10.0 %557 / 5,555

9.8 %560 / 5,698

9.8 %564 / 5,735

9.8 %580 / 5,894

9.3 %567 / 6,125

9.2 %574 / 6,226

9.3 %556 / 5,949

2.5 %54 / 2,197

5.9 %302 / 5,112

6.2 %275 / 4,431

6.8 %392 / 5,804

7.3 %421 / 5,794

6.7 %405 / 6,041

7.1 %405 / 5,672

10.8 %445 / 4,127

9.3 %411 / 4,407

9.9 %417 / 4,202

8.8 %377 / 4,286

4.2 %346 / 8,297

9.8 %450 / 4,581

10.0 %467 / 4,652

10.2 %460 / 4,507

9.4 %458 / 4,892

8.8 %447 / 5,100

8.4 %431 / 5,149

8.1 %438 / 5,393

10.3 %451 / 4,370

8.7 %470 / 5,433

9.4 %472 / 5,007

8.8 %464 / 5,281

6.8 %461 / 6,738

7.7 %433 / 5,602

8.0 %483 / 6,013

7.6 %433 / 5,698

8.1 %430 / 5,310

9.1 %505 / 5,549

9.7 %519 / 5,334

10.0 %531 / 5,332

9.3 %518 / 5,553

9.8 %500 / 5,111

9.6 %505 / 5,251

9.6 %508 / 5,288

9.9 %538 / 5,416

9.2 %520 / 5,665

8.8 %508 / 5,792

8.8 %487 / 5,525

3.0 %92 / 3,028

35.6 %1,447 / 4,066

5.9 %394 / 6,685

5.7 %381 / 6,723

5.9 %408 / 6,925

5.0 %330 / 6,593

5.5 %283 / 5,189

4.7 %255 / 5,471

4.6 %243 / 5,273

3.9 %207 / 5,371

4.5 %406 / 9,105

5.6 %313 / 5,602

5.6 %319 / 5,690

5.6 %309 / 5,540

5.3 %312 / 5,905

4.9 %302 / 6,138

4.9 %300 / 6,175

4.7 %304 / 6,419

5.3 %289 / 5,419

5.6 %359 / 6,442

5.9 %356 / 6,011

5.6 %351 / 6,283

5.4 %410 / 7,632

6.1 %396 / 6,488

6.5 %447 / 6,893

4.4 %296 / 6,737

4.6 %295 / 6,348

4.9 %322 / 6,616

5.0 %319 / 6,422

4.9 %318 / 6,437

4.8 %319 / 6,646

5.1 %318 / 6,179

5.0 %317 / 6,327

5.0 %320 / 6,363

5.0 %327 / 6,520

4.8 %324 / 6,760

4.7 %323 / 6,866

4.8 %315 / 6,588

4.2 %93 / 2,224

5.3 %321 / 6,073

5.1 %313 / 6,096

6.0 %372 / 6,237

4.8 %285 / 5,963

5.8 %261 / 4,506

5.0 %238 / 4,784

4.8 %221 / 4,593

3.9 %185 / 4,685

3.7 %315 / 8,506

5.4 %266 / 4,949

5.5 %275 / 5,030

5.7 %276 / 4,876

5.3 %275 / 5,238

4.8 %265 / 5,464

4.7 %261 / 5,499

4.5 %261 / 5,761

5.6 %264 / 4,736

5.4 %313 / 5,795

5.9 %315 / 5,358

5.4 %302 / 5,644

4.8 %338 / 7,067

5.5 %327 / 5,909

5.7 %359 / 6,332

4.3 %261 / 6,066

4.6 %261 / 5,675

4.6 %278 / 5,995

4.8 %279 / 5,802

4.9 %284 / 5,804

4.7 %281 / 6,018

4.9 %274 / 5,554

4.8 %275 / 5,698

4.8 %277 / 5,738

4.7 %279 / 5,906

4.6 %279 / 6,129

4.5 %281 / 6,235

4.6 %274 / 5,955

4.3 %160 / 3,743

29.9 %1,791 / 5,988

17.7 %1,213 / 6,866

5.5 %402 / 7,355

6.5 %384 / 5,877

5.9 %361 / 6,153

6.0 %359 / 5,951

5.0 %301 / 6,070

10.9 %1,007 / 9,235

5.8 %367 / 6,343

6.0 %385 / 6,410

6.0 %374 / 6,277

5.5 %369 / 6,663

5.3 %361 / 6,865

5.1 %353 / 6,914

5.1 %363 / 7,144

5.9 %363 / 6,145

6.1 %433 / 7,144

6.5 %435 / 6,712

6.3 %436 / 6,975

5.6 %470 / 8,386

6.5 %471 / 7,231

6.7 %512 / 7,652

5.3 %396 / 7,426

5.6 %395 / 7,036

6.3 %461 / 7,276

6.6 %464 / 7,082

6.5 %464 / 7,089

6.4 %465 / 7,302

6.7 %457 / 6,841

6.5 %456 / 6,987

6.5 %457 / 7,028

6.6 %472 / 7,172

6.1 %455 / 7,414

6.2 %463 / 7,521

6.1 %446 / 7,253

3.9 %146 / 3,755

19.5 %1,300 / 6,665

5.3 %394 / 7,374

6.6 %390 / 5,895

5.8 %356 / 6,171

6.0 %356 / 5,978

5.2 %313 / 6,075

10.3 %958 / 9,290

6.0 %380 / 6,357

6.1 %395 / 6,431

6.1 %383 / 6,294

5.7 %382 / 6,646

5.4 %374 / 6,878

5.3 %370 / 6,924

5.2 %374 / 7,164

6.0 %371 / 6,165

5.9 %427 / 7,188

6.4 %430 / 6,754

6.0 %421 / 7,026

5.3 %449 / 8,427

6.2 %449 / 7,290

6.4 %492 / 7,711

5.8 %425 / 7,390

5.9 %417 / 7,015

6.2 %450 / 7,302

6.5 %459 / 7,099

6.5 %462 / 7,100

6.4 %467 / 7,312

6.5 %445 / 6,870

6.4 %448 / 7,012

6.4 %451 / 7,050

6.6 %474 / 7,186

6.1 %456 / 7,433

6.1 %462 / 7,540

6.0 %439 / 7,271

7.9 %299 / 3,777

5.5 %416 / 7,605

6.6 %403 / 6,129

5.7 %367 / 6,406

5.9 %369 / 6,210

5.1 %320 / 6,306

9.4 %900 / 9,590

5.9 %387 / 6,598

6.1 %404 / 6,670

6.1 %399 / 6,523

5.7 %395 / 6,885

5.6 %394 / 7,087

5.3 %381 / 7,155

5.1 %380 / 7,409

6.2 %398 / 6,373

5.9 %441 / 7,417

6.4 %445 / 6,982

6.0 %436 / 7,254

5.4 %468 / 8,664

6.1 %461 / 7,513

6.3 %502 / 7,936

5.2 %396 / 7,651

5.4 %391 / 7,278

5.6 %422 / 7,576

5.7 %424 / 7,377

5.7 %424 / 7,386

5.6 %425 / 7,600

5.8 %416 / 7,149

5.7 %417 / 7,292

5.7 %420 / 7,327

5.8 %435 / 7,458

5.4 %414 / 7,720

5.5 %431 / 7,814

5.5 %414 / 7,548

3.8 %140 / 3,654

18.5 %952 / 5,137

15.9 %872 / 5,475

17.0 %892 / 5,253

15.1 %812 / 5,386

4.1 %402 / 9,768

13.7 %789 / 5,764

14.0 %814 / 5,822

14.4 %816 / 5,671

12.9 %780 / 6,070

12.5 %784 / 6,282

12.2 %774 / 6,336

11.9 %782 / 6,565

14.3 %796 / 5,553

13.6 %890 / 6,530

14.7 %897 / 6,094

14.2 %901 / 6,356

16.8 %1,235 / 7,347

14.2 %933 / 6,590

14.7 %1,021 / 6,959

18.1 %1,162 / 6,436

19.2 %1,160 / 6,045

17.2 %1,105 / 6,418

17.7 %1,101 / 6,228

17.6 %1,097 / 6,247

17.2 %1,109 / 6,439

18.1 %1,087 / 5,993

18.0 %1,102 / 6,124

18.0 %1,108 / 6,161

17.9 %1,126 / 6,297

16.9 %1,106 / 6,558

16.7 %1,111 / 6,650

16.7 %1,073 / 6,412

2.1 %48 / 2,238

57.7 %1,755 / 3,039

55.2 %1,637 / 2,968

25.1 %937 / 3,733

4.4 %364 / 8,323

20.0 %841 / 4,198

20.6 %876 / 4,262

21.0 %864 / 4,121

18.9 %851 / 4,499

17.9 %843 / 4,712

17.2 %820 / 4,774

16.4 %824 / 5,016

21.0 %841 / 4,003

19.3 %952 / 4,935

21.0 %953 / 4,528

19.5 %939 / 4,804

14.5 %910 / 6,284

16.5 %857 / 5,189

16.6 %925 / 5,565

19.2 %992 / 5,154

20.7 %987 / 4,767

22.2 %1,104 / 4,977

23.2 %1,111 / 4,781

23.2 %1,109 / 4,784

22.5 %1,121 / 4,979

24.0 %1,092 / 4,546

23.6 %1,106 / 4,677

23.7 %1,115 / 4,708

23.3 %1,130 / 4,855

21.7 %1,107 / 5,111

21.5 %1,119 / 5,204

21.6 %1,072 / 4,953

2.7 %66 / 2,474

47.7 %1,569 / 3,291

21.5 %866 / 4,035

3.8 %329 / 8,627

17.0 %772 / 4,528

17.4 %801 / 4,597

17.9 %796 / 4,448

15.9 %772 / 4,843

15.3 %773 / 5,047

14.7 %750 / 5,113

14.3 %762 / 5,313

17.8 %765 / 4,286

16.8 %880 / 5,248

18.2 %887 / 4,865

17.2 %882 / 5,126

12.6 %836 / 6,612

14.6 %802 / 5,503

14.7 %864 / 5,887

16.3 %896 / 5,510

17.3 %888 / 5,129

19.2 %1,022 / 5,318

20.1 %1,030 / 5,119

20.4 %1,037 / 5,094

19.7 %1,046 / 5,305

20.4 %1,001 / 4,902

20.2 %1,017 / 5,032

20.5 %1,036 / 5,053

20.1 %1,044 / 5,193

18.5 %1,012 / 5,463

18.8 %1,042 / 5,532

18.5 %982 / 5,299

2.7 %61 / 2,253

23.9 %907 / 3,799

4.1 %346 / 8,389

18.9 %810 / 4,287

19.4 %844 / 4,350

20.0 %838 / 4,194

17.8 %813 / 4,564

16.9 %812 / 4,808

16.1 %785 / 4,871

15.7 %802 / 5,101

20.1 %814 / 4,050

18.0 %911 / 5,050

19.5 %906 / 4,637

18.6 %912 / 4,894

13.2 %843 / 6,407

14.5 %773 / 5,342

14.8 %844 / 5,722

17.2 %909 / 5,299

18.4 %903 / 4,912

20.6 %1,047 / 5,093

21.3 %1,045 / 4,905

21.3 %1,047 / 4,911

20.7 %1,057 / 5,109

22.2 %1,036 / 4,663

21.8 %1,046 / 4,799

21.6 %1,044 / 4,841

21.0 %1,052 / 5,000

20.0 %1,048 / 5,231

19.9 %1,057 / 5,319

20.1 %1,021 / 5,072

3.1 %73 / 2,330

3.5 %295 / 8,495

16.4 %725 / 4,423

16.6 %748 / 4,493

17.3 %751 / 4,331

15.5 %730 / 4,722

14.6 %721 / 4,947

13.9 %696 / 5,019

13.8 %723 / 5,228

17.0 %713 / 4,201

15.6 %814 / 5,205

16.7 %801 / 4,810

16.0 %812 / 5,061

12.3 %801 / 6,493

13.1 %712 / 5,440

13.3 %773 / 5,828

17.0 %907 / 5,342

18.3 %906 / 4,958

22.3 %1,122 / 5,042

23.0 %1,117 / 4,851

23.0 %1,119 / 4,856

22.3 %1,126 / 5,057

24.5 %1,125 / 4,596

23.7 %1,125 / 4,742

23.6 %1,129 / 4,779

23.2 %1,141 / 4,919

21.7 %1,121 / 5,174

21.6 %1,137 / 5,265

21.9 %1,096 / 5,014

4.5 %273 / 6,050

4.3 %380 / 8,751

4.4 %391 / 8,826

4.3 %378 / 8,690

4.2 %377 / 9,078

4.0 %371 / 9,276

3.9 %365 / 9,317

3.8 %365 / 9,563

4.2 %360 / 8,570

4.4 %423 / 9,573

4.6 %422 / 9,148

4.5 %427 / 9,411

4.5 %486 / 10,772

4.7 %457 / 9,662

5.1 %510 / 10,071

3.7 %368 / 9,874

3.8 %364 / 9,486

4.5 %439 / 9,715

4.6 %434 / 9,530

4.6 %437 / 9,542

4.5 %441 / 9,748

4.6 %424 / 9,294

4.5 %428 / 9,436

4.6 %432 / 9,472

4.7 %451 / 9,614

4.4 %431 / 9,869

4.4 %437 / 9,964

4.3 %417 / 9,697

1.9 %51 / 2,725

79.7 %2,451 / 3,077

74.3 %2,296 / 3,090

70.2 %2,359 / 3,360

70.0 %2,446 / 3,494

65.1 %2,366 / 3,635

63.6 %2,425 / 3,810

65.8 %2,085 / 3,170

21.2 %1,109 / 5,240

23.2 %1,115 / 4,804

21.6 %1,097 / 5,090

15.7 %1,035 / 6,607

19.0 %1,038 / 5,457

18.9 %1,102 / 5,842

12.4 %732 / 5,894

13.3 %732 / 5,502

15.8 %893 / 5,636

16.3 %888 / 5,453

16.5 %901 / 5,450

15.9 %898 / 5,650

17.0 %885 / 5,206

16.6 %887 / 5,349

16.5 %890 / 5,387

16.2 %898 / 5,539

15.5 %892 / 5,772

15.3 %899 / 5,876

15.8 %884 / 5,605

2.3 %65 / 2,799

75.2 %2,341 / 3,115

67.9 %2,355 / 3,466

70.7 %2,489 / 3,519

63.8 %2,362 / 3,702

61.1 %2,394 / 3,921

67.2 %2,144 / 3,190

21.5 %1,140 / 5,297

23.7 %1,151 / 4,852

22.0 %1,130 / 5,142

16.1 %1,070 / 6,656

19.5 %1,070 / 5,501

19.4 %1,144 / 5,886

12.7 %759 / 5,957

13.6 %757 / 5,565

16.3 %925 / 5,683

16.7 %921 / 5,501

16.9 %930 / 5,510

16.3 %930 / 5,713

17.4 %916 / 5,257

17.0 %920 / 5,397

17.0 %926 / 5,433

16.6 %926 / 5,595

15.9 %927 / 5,822

15.7 %932 / 5,930

16.1 %913 / 5,666

2.1 %56 / 2,656

67.5 %2,273 / 3,366

65.2 %2,310 / 3,542

62.0 %2,250 / 3,631

61.1 %2,325 / 3,804

68.7 %2,099 / 3,055

21.5 %1,111 / 5,170

23.6 %1,117 / 4,735

22.2 %1,113 / 5,008

16.1 %1,051 / 6,521

19.1 %1,031 / 5,392

19.1 %1,103 / 5,781

13.0 %756 / 5,805

14.0 %756 / 5,411

16.4 %910 / 5,550

17.1 %915 / 5,357

17.2 %924 / 5,365

16.5 %921 / 5,574

17.8 %909 / 5,114

17.4 %912 / 5,256

17.3 %914 / 5,294

16.8 %917 / 5,455

16.1 %915 / 5,682

15.8 %917 / 5,791

16.3 %900 / 5,525

4.8 %140 / 2,895

66.5 %2,424 / 3,645

61.1 %2,343 / 3,835

61.5 %2,412 / 3,923

60.7 %2,065 / 3,402

19.4 %1,082 / 5,572

20.9 %1,078 / 5,159

20.0 %1,082 / 5,397

14.6 %1,013 / 6,947

17.5 %1,013 / 5,794

17.5 %1,079 / 6,171

11.8 %728 / 6,195

12.5 %726 / 5,804

14.8 %882 / 5,965

15.1 %876 / 5,785

15.7 %904 / 5,757

14.9 %892 / 5,973

15.9 %879 / 5,531

15.5 %882 / 5,673

15.5 %886 / 5,710

15.0 %884 / 5,877

14.5 %886 / 6,100

14.5 %896 / 6,192

14.9 %880 / 5,919

4.1 %128 / 3,094

68.4 %2,514 / 3,673

66.8 %2,588 / 3,874

56.8 %2,078 / 3,660

18.9 %1,091 / 5,768

20.5 %1,093 / 5,336

19.6 %1,096 / 5,603

14.5 %1,033 / 7,120

17.6 %1,046 / 5,943

17.4 %1,103 / 6,330

11.4 %733 / 6,403

12.1 %730 / 6,013

14.6 %895 / 6,145

14.9 %888 / 5,965

15.1 %901 / 5,968

14.6 %899 / 6,168

15.4 %880 / 5,724

15.2 %889 / 5,859

15.0 %888 / 5,901

14.6 %888 / 6,063

14.1 %887 / 6,292

14.1 %901 / 6,386

14.3 %878 / 6,129

5.8 %172 / 2,971

62.3 %2,481 / 3,980

53.6 %2,013 / 3,758

18.5 %1,077 / 5,831

20.0 %1,078 / 5,399

18.8 %1,067 / 5,669

14.0 %1,006 / 7,175

16.9 %1,018 / 6,020

16.8 %1,077 / 6,424

11.0 %712 / 6,450

11.7 %710 / 6,062

13.8 %856 / 6,221

14.0 %848 / 6,044

14.2 %860 / 6,041

13.8 %861 / 6,250

14.7 %850 / 5,784

14.4 %853 / 5,926

14.3 %854 / 5,973

14.0 %856 / 6,133

13.4 %853 / 6,363

13.4 %863 / 6,461

13.7 %847 / 6,189

5.0 %165 / 3,318

52.0 %2,056 / 3,951

18.0 %1,090 / 6,048

19.3 %1,085 / 5,631

18.3 %1,081 / 5,901

13.7 %1,017 / 7,419

16.6 %1,035 / 6,241

16.6 %1,098 / 6,625

10.9 %727 / 6,700

11.5 %723 / 6,310

13.3 %863 / 6,468

13.9 %873 / 6,267

14.2 %890 / 6,257

13.6 %881 / 6,471

14.5 %875 / 6,014

14.3 %878 / 6,155

14.2 %878 / 6,197

13.9 %883 / 6,354

13.3 %877 / 6,587

13.2 %883 / 6,689

13.5 %866 / 6,420

2.7 %65 / 2,449

21.2 %1,074 / 5,070

23.2 %1,078 / 4,652

21.6 %1,062 / 4,927

15.8 %1,018 / 6,423

19.2 %1,012 / 5,273

19.4 %1,094 / 5,649

13.0 %741 / 5,683

14.0 %741 / 5,292

16.3 %887 / 5,429

16.9 %889 / 5,253

17.2 %903 / 5,251

16.3 %891 / 5,472

17.7 %885 / 5,008

17.2 %887 / 5,151

17.2 %890 / 5,188

16.8 %898 / 5,344

15.9 %889 / 5,574

15.8 %894 / 5,664

16.2 %876 / 5,400

4.2 %145 / 3,486

71.3 %2,772 / 3,887

59.5 %2,579 / 4,337

25.3 %1,698 / 6,707

30.2 %1,692 / 5,606

31.1 %1,829 / 5,886

13.4 %885 / 6,601

14.2 %883 / 6,209

17.4 %1,094 / 6,285

17.8 %1,088 / 6,101

17.6 %1,076 / 6,121

17.6 %1,107 / 6,286

18.1 %1,063 / 5,882

17.9 %1,077 / 6,013

17.9 %1,085 / 6,045

17.7 %1,096 / 6,198

17.0 %1,094 / 6,418

16.9 %1,101 / 6,521

17.0 %1,063 / 6,266

3.4 %107 / 3,116

63.8 %2,531 / 3,968

26.5 %1,672 / 6,318

31.6 %1,653 / 5,224

31.9 %1,772 / 5,553

14.1 %874 / 6,198

15.0 %873 / 5,801

18.3 %1,075 / 5,877

19.1 %1,086 / 5,682

18.8 %1,071 / 5,706

18.3 %1,083 / 5,904

19.1 %1,048 / 5,476

18.9 %1,062 / 5,608

18.9 %1,066 / 5,646

18.6 %1,077 / 5,795

17.9 %1,075 / 6,014

17.7 %1,083 / 6,120

17.6 %1,037 / 5,882

3.7 %124 / 3,363

26.6 %1,727 / 6,481

29.2 %1,613 / 5,527

29.6 %1,733 / 5,850

13.9 %890 / 6,425

14.7 %885 / 6,036

17.7 %1,084 / 6,114

18.3 %1,084 / 5,925

17.9 %1,069 / 5,960

17.9 %1,097 / 6,136

18.5 %1,054 / 5,710

18.3 %1,068 / 5,841

18.4 %1,078 / 5,874

18.1 %1,091 / 6,021

17.4 %1,088 / 6,244

17.0 %1,083 / 6,363

17.1 %1,047 / 6,108

7.2 %326 / 4,529

27.5 %1,827 / 6,641

28.4 %1,965 / 6,925

14.9 %1,123 / 7,549

15.7 %1,122 / 7,166

15.3 %1,140 / 7,465

15.7 %1,141 / 7,272

15.5 %1,132 / 7,285

15.3 %1,146 / 7,488

15.7 %1,107 / 7,064

15.6 %1,124 / 7,193

15.7 %1,135 / 7,218

15.6 %1,147 / 7,356

15.0 %1,139 / 7,598

14.4 %1,115 / 7,729

14.4 %1,078 / 7,463

4.3 %156 / 3,612

88.0 %3,574 / 4,060

12.3 %835 / 6,785

13.1 %834 / 6,389

14.4 %945 / 6,571

14.8 %942 / 6,385

14.8 %943 / 6,386

14.4 %948 / 6,597

14.9 %916 / 6,163

14.7 %923 / 6,299

14.6 %928 / 6,344

14.8 %956 / 6,473

14.1 %944 / 6,707

13.8 %938 / 6,817

14.1 %924 / 6,540

5.1 %202 / 3,999

12.7 %910 / 7,161

13.3 %903 / 6,771

14.9 %1,031 / 6,936

15.2 %1,024 / 6,754

15.2 %1,024 / 6,738

14.9 %1,031 / 6,942

15.2 %996 / 6,536

15.1 %1,007 / 6,668

15.0 %1,011 / 6,718

15.3 %1,044 / 6,841

14.5 %1,025 / 7,074

14.3 %1,027 / 7,172

14.6 %1,005 / 6,890

6.6 %237 / 3,577

89.3 %3,250 / 3,641

18.7 %1,198 / 6,414

19.5 %1,210 / 6,201

19.3 %1,200 / 6,213

19.6 %1,245 / 6,366

19.7 %1,178 / 5,990

19.6 %1,198 / 6,115

20.0 %1,220 / 6,113

19.2 %1,209 / 6,286

18.3 %1,198 / 6,541

18.4 %1,222 / 6,630

18.2 %1,165 / 6,401

5.3 %173 / 3,285

19.8 %1,192 / 6,028

20.7 %1,205 / 5,814

20.5 %1,196 / 5,828

20.6 %1,237 / 5,995

20.9 %1,173 / 5,601

20.8 %1,190 / 5,729

21.1 %1,211 / 5,739

20.5 %1,206 / 5,897

19.4 %1,195 / 6,152

19.4 %1,212 / 6,250

19.1 %1,151 / 6,027

4.3 %157 / 3,651

76.0 %3,075 / 4,048

71.6 %2,977 / 4,158

69.0 %2,987 / 4,330

72.7 %2,897 / 3,986

73.6 %2,970 / 4,035

71.2 %2,938 / 4,127

65.5 %2,857 / 4,361

71.7 %3,109 / 4,337

67.8 %3,042 / 4,488

66.2 %2,876 / 4,346

4.1 %143 / 3,469

77.0 %3,016 / 3,916

76.7 %3,087 / 4,027

76.6 %2,905 / 3,794

77.4 %2,976 / 3,843

75.1 %2,952 / 3,932

69.1 %2,876 / 4,161

69.6 %2,983 / 4,285

66.7 %2,945 / 4,412

64.9 %2,788 / 4,294

5.1 %176 / 3,444

79.3 %3,145 / 3,964

76.2 %2,901 / 3,806

75.6 %2,946 / 3,898

75.3 %2,952 / 3,920

67.6 %2,846 / 4,213

67.6 %2,938 / 4,349

68.1 %2,975 / 4,366

65.6 %2,813 / 4,286

5.5 %198 / 3,623

74.2 %2,939 / 3,962

74.3 %2,996 / 4,032

75.4 %3,046 / 4,040

66.5 %2,893 / 4,351

67.4 %3,002 / 4,454

69.1 %3,080 / 4,455

64.6 %2,845 / 4,401

4.1 %133 / 3,229

94.7 %3,209 / 3,387

86.5 %3,084 / 3,566

69.1 %2,779 / 4,020

69.3 %2,880 / 4,154

67.5 %2,867 / 4,249

65.7 %2,720 / 4,140

4.7 %159 / 3,349

86.1 %3,137 / 3,645

68.9 %2,830 / 4,105

68.8 %2,922 / 4,248

67.9 %2,926 / 4,312

65.2 %2,754 / 4,226

4.2 %144 / 3,409

68.3 %2,833 / 4,149

68.1 %2,925 / 4,295

70.3 %3,003 / 4,271

63.8 %2,742 / 4,296

4.6 %162 / 3,543

62.9 %2,849 / 4,527

61.0 %2,830 / 4,637

60.0 %2,696 / 4,491

4.0 %153 / 3,795

66.9 %3,080 / 4,606

64.1 %2,878 / 4,488

4.9 %188 / 3,830

76.4 %3,195 / 4,184

5.7 %198 / 3,465

Escherichia coliK-12


Bacillus anthracis Sterne


Clostridium cellulovorans 743B


Clostridium bolteae

ATCC_BA

A-613


Clostridium m

ethylpentosum

DSM

_5476


Clostridium leptum

D

SM_753


Clostridium therm

ocellum

ATCC_27405


Clostridium cellulolyticum

H10


Clostridium phytoferm

entans ISDg


Clostridium difficile 630


Clostridium bartlettii

DSM

16795


Clostridium hiranonis

DSM

_13275


Clostridium ram

osumD

SM_1402


Clostridium spiroform

e D

SM_1552


30369 Clostridium hylem

onaeD

SM 15053


Clostridium scindens

ATCC_35704


Clostridium nexile

DSM

_1787


Clostridium acetobutylicum

A

TCC_824


Clostridium novyiN

T


Clostridium botulinum

C_Eklund



D

_1873


Clostridium tetaniE88


Clostridium asparagiform

eD

SM_15981


Clostridium perfringens

NCTC_8239



ATCC_13124


Clostridium perfringens 13



C_JGS1495



B_ATCC_3626



D_JG

S_1721



E_JGS_1987



SM_101



E1_BEBeluga



Cbot_E3_AlaskaE43



B_Eklund_17B


Clostridium beijerinckii

NCIM

B_8052


Clostridium butyricum

5521


Clostridium butyricum

E4_BEBL_5262


Clostridium kluyveri

DSM

_555


Clostridium kluyveri

NBRC_12016



B1_O

kra



F_Langeland



NCTC_2916



A

2_Kyoto



A_H

all



A_A

TCC_19397



A_A

TCC_3502


Clostridium sporogenes

ATCC_15579



A3_LochM

aree



Ba4_657



Bf


Esc

heric

hia c

oli

K-12

4,14

9 pro

tein

s, 3,

912

fam

ilies

Bacill

us anth

racis

Ste

rne

5,28

7 pro

tein

s, 4,

930

fam

ilies

Clostri

dium

cellu

lovor

ans

743

B

4,50

1 pro

tein

s, 4,

240

fam

ilies

Clostri

dium

bolte

ae

ATCC_B

AA

-613

7,28

4 pro

tein

s, 6,

843

fam

ilies

Clos

tridi

um m

ethyl

pento

sum

DSM

_547

6

3,90

7 pro

tein

s, 3,

737

fam

ilies

Clostri

dium

lept

um

DSM

_753

3,92

3 pro

tein

s, 3,

756

fam

ilies

Clostri

dium

ther

moc

ellum

ATCC_2

7405

3,18

9 pro

tein

s, 2,

933

fam

ilies

Clostri

dium

cellu

lolyt

icum

H10

3,39

0 pro

tein

s, 3,

146

fam

ilies

Clostri

dium

phy

tofer

men

tans

ISD

g

3,90

2 pro

tein

s, 3,

756

fam

ilies

Clostri

dium

diff

icile

630

3,75

3 pro

tein

s, 3,

402

fam

ilies

Clostri

dium

bartl

ettii

DSM

167

95

2,78

7 pro

tein

s, 2,

690

fam

ilies

Clostri

dium

hira

nonis

DSM

_132

75

2,27

1 pro

tein

s, 2,

197

fam

ilies

Clostri

dium

ram

osum

DSM

_140

2

3,16

9 pro

tein

s, 3,

028

fam

ilies

Clostri

dium

spiro

form

e

DSM

_155

2

2,46

5 pro

tein

s, 2,

224

fam

ilies

3036

9 Clos

tridi

um h

ylem

onae

DSM

150

53

3,97

6 pro

tein

s, 3,

743

fam

ilies

Clostri

dium

scin

dens

ATCC_3

5704

3,99

5 pro

tein

s, 3,

755

fam

ilies

Clos

tridi

um n

exile

DSM

_178

7

4,23

9 pro

tein

s, 3,

777

fam

ilies

Clostri

dium

aceto

buty

licum

ATCC_8

24

3,84

8 pro

tein

s, 3,

654

fam

ilies

Clostri

dium

nov

yi

NT

2,32

5 pro

tein

s, 2,

238

fam

ilies

Clostri

dium

botu

linum

C_E

klund

2,57

8 pro

tein

s, 2,

474

fam

ilies

Clostri

dium

botu

linum

D_1

873

2,37

8 pro

tein

s, 2,

253

fam

ilies

Clostri

dium

teta

ni

E88

2,43

2 pro

tein

s, 2,

330

fam

ilies

Clostri

dium

aspa

ragi

form

e

DSM

_159

81

6,42

5 pro

tein

s, 6,

050

fam

ilies

Clostri

dium

per

fringe

ns

NCTC_8

239

2,78

4 pro

tein

s, 2,

725

fam

ilies

Clostri

dium

per

fringe

ns

ATCC_1

3124

2,87

6 pro

tein

s, 2,

799

fam

ilies

Clostri

dium

per

fringe

ns

13

2,72

3 pro

tein

s, 2,

656

fam

ilies

Clostri

dium

per

fringe

ns

C_JG

S149

5

3,10

4 pro

tein

s, 2,

895

fam

ilies

Clostri

dium

per

fringe

ns

B_A

TCC_362

6

3,30

1 pro

tein

s, 3,

094

fam

ilies

Clostri

dium

per

fringe

ns

D_J

GS_

1721

3,34

5 pro

tein

s, 2,

971

fam

ilies

Clostri

dium

per

fringe

ns

E_J

GS_

1987

3,58

6 pro

tein

s, 3,

318

fam

ilies

Clostri

dium

per

fringe

ns

SM

_101

2,57

8 pro

tein

s, 2,

449

fam

ilies

Clostri

dium

botu

linum

E1_

BEBeluga

3,68

4 pro

tein

s, 3,

486

fam

ilies

Clostri

dium

botu

linum

Cbot_

E3_A

lask

aE43

3,25

7 pro

tein

s, 3,

116

fam

ilies

Clostri

dium

botu

linum

B_E

klund_1

7B

3,52

7 pro

tein

s, 3,

363

fam

ilies

Clostri

dium

beije

rinck

ii

NCIM

B_805

2

5,02

0 pro

tein

s, 4,

529

fam

ilies

Clostri

dium

buty

ricum

5521

3,82

7 pro

tein

s, 3,

612

fam

ilies

Clostri

dium

buty

ricum

E4_

BEBL_526

2

4,30

1 pro

tein

s, 3,

999

fam

ilies

Clostri

dium

kluyv

eri

DSM

_555

3,91

3 pro

tein

s, 3,

577

fam

ilies

Clostri

dium

kluyv

eri

NBRC_1

2016

3,52

3 pro

tein

s, 3,

285

fam

ilies

Clostri

dium

botu

linum

B1_

Okra

3,85

2 pro

tein

s, 3,

651

fam

ilies

Clostri

dium

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60 Clostridium genomes

Genome analysis of multiple pathogenic isolatesof Streptococcus agalactiae: Implicationsfor the microbial ‘‘pan-genome’’Herve Tettelina,b, Vega Masignanib,c, Michael J. Cieslewiczb,d,e, Claudio Donatic, Duccio Medinic, Naomi L. Warda,f,Samuel V. Angiuolia, Jonathan Crabtreea, Amanda L. Jonesg, A. Scott Durkina, Robert T. DeBoya, Tanja M. Davidsena,Marirosa Morac, Maria Scarsellic, Immaculada Margarit y Rosc, Jeremy D. Petersona, Christopher R. Hausera,Jaideep P. Sundarama, William C. Nelsona, Ramana Madupua, Lauren M. Brinkaca, Robert J. Dodsona, Mary J. Rosovitza,Steven A. Sullivana, Sean C. Daughertya, Daniel H. Hafta, Jeremy Selenguta, Michelle L. Gwinna, Liwei Zhoua,Nikhat Zafara, Hoda Khouria, Diana Radunea, George Dimitrova, Kisha Watkinsa, Kevin J. B. O’Connorh, Shannon Smithi,Teresa R. Utterbacki, Owen Whitea, Craig E. Rubensg, Guido Grandic, Lawrence C. Madoffe,j, Dennis L. Kaspere,j,John L. Telfordc, Michael R. Wesselsd,e, Rino Rappuolic,k,l, and Claire M. Frasera,b,k,m

aInstitute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850; cChiron Vaccines, Via Fiorentina 1, 53100 Siena, Italy; dDivisionof Infectious Diseases, Children’s Hospital, 300 Longwood Avenue, Boston, MA 02115; eHarvard Medical School, Boston, MA 02115; fCenter of MarineBiotechnology, University of Maryland Biotechnology Institute, 701 East Pratt Street, Baltimore, MD 21202; gChildren’s Hospital and Regional MedicalCenter, 307 Westlake Avenue N, Seattle, WA 98109; hThe Johns Hopkins University, 3400 North Charles Street, Baltimore, MD 21218; iJ. Craig VenterInstitute, 5 Research Place, Rockville, MD 20850; jChanning Laboratory, Brigham and Women’s Hospital, 181 Longwood Avenue, Boston, MA 02115;and mGeorge Washington University Medical Center, 2300 Eye Street NW, Washington, DC 20037

Contributed by Rino Rappuoli, August 5, 2005

The development of efficient and inexpensive genome sequencingmethods has revolutionized the study of human bacterial patho-gens and improved vaccine design. Unfortunately, the sequence ofa single genome does not reflect how genetic variability drivespathogenesis within a bacterial species and also limits genome-wide screens for vaccine candidates or for antimicrobial targets.We have generated the genomic sequence of six strains represent-ing the five major disease-causing serotypes of Streptococcusagalactiae, the main cause of neonatal infection in humans. Anal-ysis of these genomes and those available in databases showedthat the S. agalactiae species can be described by a pan-genomeconsisting of a core genome shared by all isolates, accounting for!80% of any single genome, plus a dispensable genome consistingof partially shared and strain-specific genes. Mathematical extrap-olation of the data suggests that the gene reservoir available forinclusion in the S. agalactiae pan-genome is vast and that uniquegenes will continue to be identified even after sequencing hun-dreds of genomes.

bacterial species ! comparative genomics ! group B Streptococcus

The most recent definition of a bacterial species comes fromthe pregenomic era. In 1987, it was proposed (1) that

bacterial strains showing "70% DNA!DNA reassociation andsharing characteristic phenotypic traits should be considered tobe strains of the same species. Today, this classical definition isbeing challenged by an increasing amount of genomic informa-tion, which, in theory, can more precisely describe bacterialspecies. Thus far, the genome sequence of one or two strains foreach species has provided unprecedented information; however,the question of how many genomes are necessary to fullydescribe a bacterial species has yet to be asked. We haveaddressed this question by sequencing the genome of strains ofeach of the major pathogenic serotypes of Streptococcus agalac-tiae [group B Streptococcus (GBS)].

S. agalactiae is a leading cause of illness or death among newborninfants (2) and an emerging cause of invasive infection in the elderly(3, 4). Nine distinct capsular serotypes of GBS have been described;however, the major disease-causing isolates in the United Statesand Europe belong to only five serotypes: Ia, Ib, II, III, and V (5).Recently, the complete nucleotide sequences of a serotype III anda serotype V GBS isolate were reported (6, 7). To fully explore genevariability within the GBS species, we determined the complete

genome sequence of the type Ia strain A909 and draft genomesequences (8# sequence coverage) of five additional strains, rep-resenting the five major serotypes. Comparative analysis of the sixnewly sequenced genomes and the two genomes already availablein the databases suggests that a bacterial species can be describedby its ‘‘pan-genome’’ (pan, from the Greek word !"#, meaningwhole), which includes a core genome containing genes present inall strains and a dispensable genome composed of genes absentfrom one or more strains and genes that are unique to each strain.Surprisingly, unique genes were still detected after eight genomeswere sequenced, and mathematical extrapolation predicts that newgenes will still be found after sequencing many more strains. Thus,the genomes of multiple, independent isolates are required tounderstand the global complexity of bacterial species. Analysis ofmultiple GBS genomes was found to be instrumental for thedevelopment of vaccines (8) and for the functional characterizationof important genetic determinants (9).

Materials and MethodsSequenced Strains. All newly sequenced strains were deposited atAmerican Type Culture Collection under the following accessionnumbers: A909, BAA-1138; CJB111, BAA-23; H36b, BAA-1174; 18RS21, BAA-1175; COH1, BAA-1176; and 515, BAA-1177. References for the eight strains are as follows: NEM316(6); 2603V"R (7); A909, H36B, and 18RS21 (10); 515 (11);COH1 (12); and CJB111 (Carol Baker Collection, Division ofInfectious Diseases, Baylor College of Medicine, Houston).

Sequencing, Annotation, and Unfinished Genomes. Genome se-quences were generated by the whole-genome shotgun sequenc-ing approach (13, 14). Draft genomes were sequenced to 8#-

Freely available online through the PNAS open access option.

Abbreviations: GBS, group B Streptococcus; MLST, multilocus sequence typing; GAS, groupA Streptococcus.

Data deposition: The sequences reported in this paper have been deposited in the DDBJ"EMBL"GenBank database [accession nos. AAJO01000000 (18RS21), AAJP01000000 (515),AAJQ01000000 (CJB111), AAJR01000000 (COH1), AAJS01000000 (H36B), and CP000114(A909)].bH.T., V.M., and M.J.C. contributed equally to this work.kR.R. and C.M.F. contributed equally to this work.lTo whom correspondence should be addressed. E-mail: rino"[email protected].

© 2005 by The National Academy of Sciences of the USA

13950–13955 ! PNAS ! September 27, 2005 ! vol. 102 ! no. 39 www.pnas.org"cgi"doi"10.1073"pnas.0506758102

be identified and added to the pan-genome. Although the confi-dence interval is rather large, the probability that this averagenumber would be zero is smaller than 6 ! 10"4. This findingsuggests that the GBS pan-genome is open and that its size grows

with the number of independent strains sequenced (Fig. 3 Inset). Toverify whether an open pan-genome model is unique to GBS, werepeated the analysis by using the complete sequence of five strainsof Streptococcus pyogenes [group A Streptococcus (GAS)] and eightstrains of Bacillus anthracis, which are known to have differentlevels of genomic diversity (data not shown). As in the case of GBS,each additional GAS genome added an average of 27 new genes tothe pool, leading to an open pan-genome. In the case of B. anthracis,the number of specific genes added to the pan-genome dropped tozero after the addition of a fourth strain. This result probablyreflects the fact that B. anthracis is a highly clonal, recently evolvedspecies in which genome variability is associated only with virulenceplasmids (23, 24). Alternatively, the sequenced strains may belongto the same evolutionary clade and may not adequately representthe B. anthracis species.

Genome Diversity Is Independent of Capsular Serotype. Convenientphenotypic traits, such as agglutination by specific antisera againstthe capsular polysaccharide surrounding bacterial cells, have beenwidely used to classify bacteria within the same species, and thisinformation has been used for epidemiology, vaccine design, andtherapy. Recently, MLST analysis based on fragments of sevenconserved core genes indicated that the GBS serotype does not fullycorrelate with actual evolutionary relationships (7, 25). To charac-terize the genetic relationship between the eight genomes of GBSisolates, a dendrogram was drawn according to the distribution ofgenes across the strains (Fig. 4). Among the genomes compared,two belong to serotype Ia (515 and A909), two are serotype III(NEM316 and COH1), and two are serotype V (2603 and CJB111).Furthermore, strains 515 and NEM316 belong to the same ST type(ST23). Comparative analysis of the strains’ gene content (see Table7, which is published as supporting information on the PNAS website) showed that strains of different serotypes and different MLSTtype often share a higher number of genes than strains of the sameserotype, resulting in a serotype-independent clustering of the eightstrains. In support of this conclusion, global genome comparisonsat the nucleotide level indicate that strains from two different butrelated serotypes, type Ia strain 515 and type Ib strain H36B, werethe least conserved, with 85% identity over 90% of the genome,whereas the two most conserved strains, 2603V!R and COH1 (95%identity over 96% of the genome), belong to two distinct serotypes(type V and III, respectively) and to two different MLST types.

Functional Classification of the Core and Dispensable Genes. Genesbelonging to core and dispensable genomes have been classifiedaccording to their predicted functional role (see Fig. 5, which ispublished as supporting information on the PNAS web site). As

Fig. 2. GBS core genome. The number of shared genes is plotted as afunction of the number n of strains sequentially added (see Materials andMethods). For each n, circles are the 8!![(n " 1)!!(8 " n)!] values obtained forthe different strain combinations. Squares are the averages of such values. Thecontinuous curve represents the least-squares fit of the function Fc #!c exp["n!"c] $ % (see Eq. 1 in Supporting Text) to data. The best fit wasobtained with correlation r2 # 0.990 for !c # 610 & 38, "c # 2.16 & 0.28, and% # 1,806 & 16. The extrapolated GBS core genome size % is shown as a dashedline.

Fig. 3. GBS pan-genome. The number of specific genes is plotted as afunction of the number n of strains sequentially added (see Materials andMethods). For each n, circles are the 8!![(n " 1)!!(8 " n)!] values obtained forthe different strain combinations; squares are the averages of such values. Theblue curve is the least-squares fit of the function Fs(n) # !s exp["n!"s] $ tg(#)(see Eq. 2 in Supporting Text) to the data. The best fit was obtained withcorrelation r2 # 0.995 for !s # 476 & 62, "s # 1.51 & 0.15, and tg(#) # 33 & 3.5.The extrapolated average number tg(#) of strain-specific genes is shown as adashed line. (Inset) Size of the GBS pan-genome as a function of n. The redcurve is the calculated pan-genome size

P'n( $ D % tg'# ()n & 1* % !sexp)"2!"s*!1 & exp)"'n & 1(!"s*

1 & exp)"1!"s*

(see Eq. 4 in Supporting Text), with values of the parameters obtained fromthe fit of Fs(n) (see Eq. 2 in Supporting Text).

Fig. 4. Dendrogram of the eight GBS genomes. Shared gene informationwas used to cluster proteins into groups by using the single-linkage method ofthe program CLUSTER (http:!!rana.lbl.gov). Groups were then converted intoprofiles of presence or absence of each gene (0 or 1) in the eight GBS strainsand used as input to PAUP* 4.0b10 (Sinauer, Sunderland, MA) for dendrogramdrawing and bootstrapping. Numbers at the nodes indicate bootstrap values.Serotypes and MLST types of each strain are within parentheses.

Tettelin et al. PNAS " September 27, 2005 " vol. 102 " no. 39 " 13953

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be identified and added to the pan-genome. Although the confi-dence interval is rather large, the probability that this averagenumber would be zero is smaller than 6 ! 10"4. This findingsuggests that the GBS pan-genome is open and that its size grows

with the number of independent strains sequenced (Fig. 3 Inset). Toverify whether an open pan-genome model is unique to GBS, werepeated the analysis by using the complete sequence of five strainsof Streptococcus pyogenes [group A Streptococcus (GAS)] and eightstrains of Bacillus anthracis, which are known to have differentlevels of genomic diversity (data not shown). As in the case of GBS,each additional GAS genome added an average of 27 new genes tothe pool, leading to an open pan-genome. In the case of B. anthracis,the number of specific genes added to the pan-genome dropped tozero after the addition of a fourth strain. This result probablyreflects the fact that B. anthracis is a highly clonal, recently evolvedspecies in which genome variability is associated only with virulenceplasmids (23, 24). Alternatively, the sequenced strains may belongto the same evolutionary clade and may not adequately representthe B. anthracis species.

Genome Diversity Is Independent of Capsular Serotype. Convenientphenotypic traits, such as agglutination by specific antisera againstthe capsular polysaccharide surrounding bacterial cells, have beenwidely used to classify bacteria within the same species, and thisinformation has been used for epidemiology, vaccine design, andtherapy. Recently, MLST analysis based on fragments of sevenconserved core genes indicated that the GBS serotype does not fullycorrelate with actual evolutionary relationships (7, 25). To charac-terize the genetic relationship between the eight genomes of GBSisolates, a dendrogram was drawn according to the distribution ofgenes across the strains (Fig. 4). Among the genomes compared,two belong to serotype Ia (515 and A909), two are serotype III(NEM316 and COH1), and two are serotype V (2603 and CJB111).Furthermore, strains 515 and NEM316 belong to the same ST type(ST23). Comparative analysis of the strains’ gene content (see Table7, which is published as supporting information on the PNAS website) showed that strains of different serotypes and different MLSTtype often share a higher number of genes than strains of the sameserotype, resulting in a serotype-independent clustering of the eightstrains. In support of this conclusion, global genome comparisonsat the nucleotide level indicate that strains from two different butrelated serotypes, type Ia strain 515 and type Ib strain H36B, werethe least conserved, with 85% identity over 90% of the genome,whereas the two most conserved strains, 2603V!R and COH1 (95%identity over 96% of the genome), belong to two distinct serotypes(type V and III, respectively) and to two different MLST types.

Functional Classification of the Core and Dispensable Genes. Genesbelonging to core and dispensable genomes have been classifiedaccording to their predicted functional role (see Fig. 5, which ispublished as supporting information on the PNAS web site). As

Fig. 2. GBS core genome. The number of shared genes is plotted as afunction of the number n of strains sequentially added (see Materials andMethods). For each n, circles are the 8!![(n " 1)!!(8 " n)!] values obtained forthe different strain combinations. Squares are the averages of such values. Thecontinuous curve represents the least-squares fit of the function Fc #!c exp["n!"c] $ % (see Eq. 1 in Supporting Text) to data. The best fit wasobtained with correlation r2 # 0.990 for !c # 610 & 38, "c # 2.16 & 0.28, and% # 1,806 & 16. The extrapolated GBS core genome size % is shown as a dashedline.

Fig. 3. GBS pan-genome. The number of specific genes is plotted as afunction of the number n of strains sequentially added (see Materials andMethods). For each n, circles are the 8!![(n " 1)!!(8 " n)!] values obtained forthe different strain combinations; squares are the averages of such values. Theblue curve is the least-squares fit of the function Fs(n) # !s exp["n!"s] $ tg(#)(see Eq. 2 in Supporting Text) to the data. The best fit was obtained withcorrelation r2 # 0.995 for !s # 476 & 62, "s # 1.51 & 0.15, and tg(#) # 33 & 3.5.The extrapolated average number tg(#) of strain-specific genes is shown as adashed line. (Inset) Size of the GBS pan-genome as a function of n. The redcurve is the calculated pan-genome size

P'n( $ D % tg'# ()n & 1* % !sexp)"2!"s*!1 & exp)"'n & 1(!"s*

1 & exp)"1!"s*

(see Eq. 4 in Supporting Text), with values of the parameters obtained fromthe fit of Fs(n) (see Eq. 2 in Supporting Text).

Fig. 4. Dendrogram of the eight GBS genomes. Shared gene informationwas used to cluster proteins into groups by using the single-linkage method ofthe program CLUSTER (http:!!rana.lbl.gov). Groups were then converted intoprofiles of presence or absence of each gene (0 or 1) in the eight GBS strainsand used as input to PAUP* 4.0b10 (Sinauer, Sunderland, MA) for dendrogramdrawing and bootstrapping. Numbers at the nodes indicate bootstrap values.Serotypes and MLST types of each strain are within parentheses.

Tettelin et al. PNAS " September 27, 2005 " vol. 102 " no. 39 " 13953

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Proc Natl Acad Sci USA, 102:13950-13955 (2005).



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Total of 11,838 E. coli and Shigella gene families (32 genome sequences)

9,797 unique to E. coli and Shigella

2,041 E. coli and Shigella core families



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How large is the E. coli pan-genome? Can we estimate this?



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1 E. coli K-12 MG1655 42892 E. coli K-12 W3110 43873 E. coli K-12 DH10B 41264 E. coli CFT073 5379

#genes4289 4057 4057 4057

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1 : E. coli K12MG16552 : E. coli O157RIMD05099523 : E. coli O157EDL934 : S. flexneri 2a!3015 : E. coli CFT0736 : S. flexneri 2a!2457T7 : S. sonnei Ss0468 : S. boydii Sb2279 : S. dysenteriae Sd197

10 : E. coli W311011 : E. coli UTI8912 : E. coli 53613 : S. flexneri 5!840114 : E. coli APEC!O115 : E. coli 101!116 : E. coli 5363817 : E. coli B17118 : E. coli B7A19 : E. coli E2220 : E. coli E24377A21 : E. coli F1122 : E. coli HS23 : E. coli B24 : E. coli E11001925 : S. boydii BS512

26 : E. coli 04227 : E. coli B0328 : E. coli E234829 : E. coli H1040730 : E. coli RS218

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E. fergusoniiE. albertii

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Microbial comparative pan-genomics using binomial mixture

models

Lars Snipen!1, Trygve Almøy1and David W. Ussery2

1Biostatistics, Department of Chemistry, Biotechnology and Food Sciences, Norwegian University of Life Sciences, As, Norway2Centre for Biological Sequence Analysis, Technical University of Denmark, Lyngby, Denmark

Email: Lars Snipen!- [email protected]; Trygve Almøy - [email protected]; David W. Ussery - [email protected];

!Corresponding author

Abstract

Background: The size of the core- and pan-genome of bacterial species is a topic of increasing interest due tothe growing number of sequenced prokaryote genomes, many from the same species. Attempts to estimate thesequantities have been made, using regression methods or mixture models. We extend the latter approach by usingstatistical ideas developed for capture-recapture problems in ecology and epidemiology.

Results: We estimate core- and pan-genome sizes for 16 di!erent bacterial species. The results reveal a complexdependency structure for most species, manifested as heterogeneous detection probabilities. Estimated pan-genome sizes range from small (around 2600 gene families) in Buchnera aphidicola to large (around 43000 genefamilies) in Escherichia coli. Results for Echerichia coli show that as more data become available, a larger diversityis estimated, indicating an extensive pool of rarely occurring genes in the population.

Conclusions: Analyzing pan-genomics data with binomial mixture models is a way to handle dependencies betweengenomes, which we find is always present. A bottleneck in the estimation procedure is the annotation of rarelyoccurring genes.

Background

One of the consequences of the explosion in numbersof fully sequenced and annotated microbial genomesis that we are now facing the challenges of compara-tive pan-genomics [1]. The microbial pan-genome, asdefined by [2], is the number of essentially di!erentgenes found within a population at a specified taxo-nomic level, usually within a species, though this canbe extended to higher levels, such as genus. As mul-tiple genomes of the same species are sequenced, onecan construct the pan-genome, and begin to compare

pan-genomes from di!erent species.Having a set of fully sequenced and annotated

genomes from several strains within a species, one isinterested in two sets of genes. The first is the set ofcore genes, i.e. the genes found in every strain withina species. The size and content of the core genomeis interesting for characterizing the genomic essenceof the species. The other set is the pan-genome,which is the total number of di!erent genes found inall strains within the species. The size of this pan-genome, relative to the number of genes found in atypical strain, is an indicator of the plasticity of the

1

BMC Genomics 2009, 10: in the press [August 2009]

The Burkholderia Pan- and Core Genome 223

multiple species per genus, the E. coli pan- and core genome curves are strikingly divergent.

A study based on seven sequenced E. coli genomes predicted that the E. coli pan-genome was open, and that each new E. coli genome sequenced would have, on average, about 441 genes (Chen et al. 2006). This predicted number of new genes seems rather high, compared to the 30 or so genes predicted to be added with each new Streptococcus genome (Tettelin et al. 2005). We have estimated the number of new genes as approximately 80 per E. coli genome, based on 32 sequenced E. coli genomes; we estimate the E. coli species pan-genome to con-tain about 9433 genes, whilst the core genome contains 2241 genes (Willenbrock et al. 2007).

The Burkholderia Pan- and Core Genome

As a final example of what insights can be obtained from multiple genome sequences, we will consider the Burkholderia genus (another Proteobacteria, in this case of the !-division). There are 54 Burkholderia genomes currently avail-able, and this genus represents quite a broad spectrum of organisms, including one of the largest genomes sequenced so far (B. xenovorans is 9.8 Mbp). We included all 54 Burkholderia genomes in our analysis (Fig. 12.6). This shows an estimate of the full extent of diversity one can observe in bacterial genera. Note that in this

Pseudomonas Vibrio

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243D.W. Ussery et al., Computing for Comparative Microbial Genomics, Computational Biology 8, DOI 10.1007/978-1-84800-255-5_14, © Springer-Verlag London Limited 2009

Chapter 14Evolution of Microbial Communities; or, On the Origins of Bacterial Species

Outline Evolution can be thought of as the adaptation or optimization of species to their environment. Since, at the level of microorganisms, there can be considerable differences in microenvironments, it is not hard to imagine that many bacteria have a constant need to be adaptable and ready to change to new surroundings. In this final chapter, we will take a look at the processes that drive evolution, and at the evolutionary traces that are visible in the DNA sequences of genomes. Mobile DNA elements play an important role in evolution and an example is given for insertion sequences in Shigella flexneri. Genome islands can be considered genetic ‘building blocks’ that can be added to or removed from a genome core. Finally, we will take a closer look at Vibrio cholerae, to see how this species differs from other Vibrio spe-cies, and how a relatively small set of genes can be responsible for niche adaptation (and sometimes speciation). The amount of genomic diversity within closely related bacterial populations is far greater than anyone had imagined, and the raw material for evolution is abundant in the microbial world.

Introduction

As mentioned in the first chapter, cells obey the laws of chemistry and physics, and there is no need to invoke supernatural forces to explain the physical mechani-cal events happening inside bacterial cells. One of the undercurrent themes of this book has been to build up a firm ‘post-genomic’ foundation from which to view the bacterial communities. We’ve now come full circle, and in this last chapter, we will have a look at the evidence for evolution within individual genomes, and how we can extrapolate such observations to bacterial populations.

In order for evolution to happen, three components are necessary: (1) a number of organisms must have a diverse set of traits that have different advantages under different conditions, (2) these traits must have the ability to change, and finally (3) selection must take place by some particular condition so that (some of) these traits become dominant in the offspring population. We can add the time factor to this as an essential component, because evolution is rarely instantaneous. Before turning to biological examples, we will first take a closer look at evolution in general.



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1200

0


1 : 1

2 : 2

3 : 3

4 : 4

5 : 5

6 : 6

7 : 7

8 : 8

9 : 9

10 : 10

11 : 11

12 : 12

13 : 13

14 : 14

15 : 15

16 : 16

17 : 17

18 : 18

19 : 19

20 : 20

21 : 21

22 : 22

23 : 23

24 : 24

25 : 25

26 : 26

1=Spyogenes_MGAS3152=Spyogenes_MGAS20963=Spyogenes_MGAS103944=Spyogenes_MGAS107505=Spyogenes_MGAS102706=Spyogenes_MGAS61807=Spyogenes_MGAS50058=Spyogenes_MGAS94299=Spyogenes_MGAS823210=Spyogenes_M1_GAS11=Spyogenes_SSI-112=Spyogenes_Manfredo13=Spneumoniae_R614=Spneumoniae_TIGR415=Spneumoniae_D3916=Sthermophilus_CNRZ106617=Sthermophilus_LMD-918=Sthermophilus_LMG1831119=Ssuis_98HAH3320=Ssuis_05ZYH3321=Sagalactiae_NEM31622=Sagalactiae_A90923=Sagalactiae_2603V_R24=Ssanguinis_SK3625=Smutans_UA15926=Sgordonii_Challis_CH1

Streptococcus [26 genomes]



epartment of S

ystems B


enmark

1=Banthracis_A10552=Banthracis_Ames05813=Banthracis_Ames4=Banthracis_Australia945=Banthracis_CNEVA-90666=Banthracis_Kruger_B7=Banthracis_Sterne8=Banthracis_USA61539=Banthracis_Vollum10=Bcereus_AH18711=Bcereus_AH82012=Bcereus_ATCC10987_Main13=Bcereus_ATCC14579_Main14=Bcereus_E33L_Main15=Bcereus_G924116=Bcereus_NVH391-9817=Bsubtilis_16818=Bthuringiensis_97-2719=Bthuringiensis_AlHakam20=Bamyloliquefaciens_FZB4221=Bclausii_KSM-K1622=Bhalodurans_C-12523=Blicheniformis_ATCC1458024=Bpumilus_SAFR-032

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24

050

0010

000

1500

020

000

2500


1 : 1

2 : 2

3 : 3

4 : 4

5 : 5

6 : 6

7 : 7

8 : 8

9 : 9

10 : 10

11 : 11

12 : 12

13 : 13

14 : 14

15 : 15

16 : 16

17 : 17

18 : 18

19 : 19

20 : 20

21 : 21

22 : 22

23 : 23

24 : 24

Bacillus [24 genomes]

B. u

bone

nsis

B. v

ietn

amie

nsis

B. o

klah

omen

sis

10 000

20 000

30 000

40 000

B. cepacia complex Pseudomallei group

B. a

mbi

faria B. pseudomallei B. mallei

B. c

enoc

epac

ia

B. l

ata

B. m

ullti

vora

ns

B. d

olos

a

B. t

haila

nden

sis

B. p

hyto

firm

ans

B. p

hym

atum

Bur

khol

deria

H16

0B

. xen

ovor

ans

B. g

ram

inis

Genomes (n=56)

Num

ber

of g

enes

and

gen

e fa

mili

esPan-genomeCore genome

Novel gene familiesNovel genes Burkholderia [56 genomes]

1 3 5 7 9 11 13 15 17 19 21 23 25 27 29 31 33 35 37 39 41 43 45 47 49 51 53

010

000

2000

030

000

4000

050

000

6000

0


1 : 12 : 23 : 34 : 45 : 56 : 67 : 78 : 89 : 910 : 1011 : 1112 : 1213 : 1314 : 1415 : 1516 : 1617 : 1718 : 1819 : 1920 : 2021 : 2122 : 2223 : 2324 : 2425 : 2526 : 2627 : 2728 : 2829 : 2930 : 3031 : 3132 : 3233 : 3334 : 3435 : 3536 : 3637 : 3738 : 3839 : 3940 : 4041 : 4142 : 4243 : 4344 : 4445 : 4546 : 4647 : 4748 : 4849 : 4950 : 5051 : 5152 : 5253 : 5354 : 54

# genes in human genome (!)

Burkholderia



epartment of S

ystems B


enmark

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15

050

0010

000

1500

020

000

2500

030

000


1 : 1

2 : 2

3 : 3

4 : 4

5 : 5

6 : 6

7 : 7

8 : 8

9 : 9

10 : 10

11 : 11

12 : 12

13 : 13

14 : 14

15 : 15

1=Cperfringens_132=Cperfringens_ATCC131243=Cperfringens_SM1014=Cbotulinum_A_ATCC_193975=Cbotulinum_F_Langeland6=Cdifficile_6307=Ctetani_E888=Cacetobutylicum_ATCC8249=Cbeijerincki_NCIMB_805210=Ccellulolyticum_H1011=Cnovyi_NT12=Cphytofermentans_ISDg13=Csp_OhILAs14=Cthermocellum_ATCC2740515=Ckluyveri_DSM555

Clostridium [15 genomes]

1 3 5 7 9 11 14 17 20 23 26 29 32 35 38 41 44 47 50

020000

40000

60000

80000

New genes

New gene families

Core genome

Pan genome

1 : Clostridium botulinum Bf2 : Clostridium botulinum Ba4 str. 6573 : Clostridium botulinum A3 str. Loch Maree4 : Clostridium sporogenes ATCC 155795 : Clostridium botulinum A str. ATCC 35026 : Clostridium botulinum A str. ATCC 193977 : Clostridium botulinum A str. Hall8 : Clostridium botulinum A2 str. Kyoto9 : Clostridium botulinum NCTC 291610 : Clostridium botulinum F str. Langeland11 : Clostridium botulinum B1 str. Okra12 : Clostridium kluyveri DSM 55513 : Clostridium kluyveri NBRC 1201614 : Clostridium butyricum E4 str. BoNT E BL526215 : Clostridium butyricum 552116 : Clostridium beijerinckii NCIMB 805217 : Clostridium botulinum B str. Eklund 17B18 : Clostridium botulinum E3 str. Alaska E4319 : Clostridium botulinum E1 str. BoNT E Beluga20 : Clostridium perfringens SM10121 : Clostridium perfringens E str. JGS198722 : Clostridium perfringens D str. JGS172123 : Clostridium perfringens B str. ATCC 362624 : Clostridium perfringens C str. JGS149525 : Clostridium perfringens str. 1326 : Clostridium perfringens ATCC 1312427 : Clostridium perfringens NCTC 823928 : Clostridium perfringens CPE str. F496929 : Clostridium asparagiforme DSM 1598130 : Clostridium tetani E8831 : Clostridium botulinum D str. 187332 : Clostridium botulinum C str. Eklund33 : Clostridium novyi NT34 : Clostridium acetobutylicum ATCC 82435 : Clostridium cellulovorans 743B36 : Clostridium nexile DSM 178737 : Clostridium scindens ATCC 3570438 : Clostridium hylemonae DSM 1505339 : Clostridium spiroforme DSM 155240 : Clostridium ramosum DSM 140241 : Clostridium hiranonis DSM 1327542 : Clostridium bartlettii DSM 1679543 : Clostridium difficile 63044 : Clostridium phytofermentans ISDg45 : Clostridium cellulolyticum H1046 : Clostridium thermocellum ATCC 2740547 : Clostridium leptum DSM 75348 : Clostridium methylpentosum DSM 547649 : Clostridium bolteae ATCC BAA!61350 : Clostridium cellulovorans 743B51 : Bacillus anthracis str. Sterne52 : Escerichia Coli str. K12 MG1655

# genes in human genome (!)



epartment of S

ystems B


enmark

! " # $ % & ' ( ) !* !! !" !# !$ !% !& !' !( !) "*

*!***

"***

#***

$***

%***

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#.;..734<=68>3?@,9.A,AB05.7F($(&

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!$.;..734<=68>3?@,9.?865.DE"""(

!%.;..734<=68>3?@,9.6395.DE"!**

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! " # $ % & ' ( ) !* !! !" !# !$ !% !& !' !( !) "*

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!).;..734<=68>3?@,9.M845051.HJ77KIHH!#(!

"*.;..734<=68>3?@,9.?B9NB1.%"%C)"



epartment of S

ystems B


enmark

Vibrio [28 genomes]5e+

02

V.vulnificus V.profundumV.parahaemolyticus OthersV.cholerae

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28

05000

10000

15000

20000 Newgenes

CoregenomePangenome

P. profundum



epartment of S

ystems B


enmark

Pan genome

Core genome

New gene families

V. c

hole

rae N

16961

V. c

hole

rae M

66-2

V. c

hole

rae O

395 T

ED

A

V. c

hole

rae O

395 T

IGR

V. c

hole

rae M

O10

V. c

hole

rae B

X330286

V. c

hole

rae R

C9

V. c

hole

rae M

J1236

V. c

hole

rae B

33V

CE

V. c

hole

rae 2

740-8

0

V. c

hole

rae 1

587

V. c

hole

rae A

M-1

9226

V. c

hole

rae M

ZO

-2

V. c

hole

rae 1

2129

V. c

hole

rae T

MA

21

V. c

hole

rae T

M11079-8

0

V. c

hole

rae V

L426

V. c

hole

rae V

52

Vib

rio. s

p M

ED

222

V.s

ple

ndid

us L

GB

2

A. fis

heri E

S114

A. fis

heri M

J11

A.s

alm

onic

ida L

FI1

238

Vib

rio s

p E

x25

V.c

am

pbellii

V.h

arv

eyi B

AA

-1116

V.s

hilo

nii A

K1

P.p

rofu

ndum

SS

9

V. p

ara

haem

. 2210633

V. p

ara

haem

. 16

V. v

uln

ificus C

MC

P6

V. v

uln

ificus Y

J016

5000

25000

20000

10000

0

15000



epartment of S

ystems B


enmark

Mycobacterium [18 genomes]

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18

050

0010

000

1500

020

000

New genesNew gene familiesCore genomePan genome 1 : 1

2 : 2

3 : 3

4 : 4

5 : 5

6 : 6

7 : 7

8 : 8

9 : 9

10 : 10

11 : 11

12 : 12

13 : 13

14 : 14

15 : 15

16 : 16

17 : 17

18 : 18

1=Mtuberculosis_CDC15512=Mtuberculosis_C3=Mtuberculosis_F114=Mtuberculosis_H37Ra5=Mtuberculosis_H37Rv6=Mtuberculosis_Haarlem7=Msp_JLS8=Msp_KMS9=Msp_MCS10=Mavium_10411=Mavium_K-1012=Mbovis_AF2122_9713=Mbovis_BCG14=Mgilvum_PYR-GCK15=Mleprae_TN16=Msmegmatis_MC2_15517=Mulcerans_Agy9918=Mvanbaalenii_PYR-1



epartment of S

ystems B


enmark

Genus length %AT core pan #genomes

Streptococcus ~2 Mbp 62% 800 10,000 26 [63]

Burkholderia 5-10 Mbp 31% 900 32,000 36 [55]

Bacillus 4-5 Mbp 63% 500 22,000 24 [48]

Clostridium 2-5 Mbp 72% 200 27,000 15 [43]

Vibrio 4-6 Mbp 53% 800 23,000 28 [35]

Mycobacterium 3-5 Mbp 43% 900 16,000 18 [30]

Salmonella ~5 Mbp 48% 2300 8,400 24 [30]

Yersinia ~5 Mbp 52% 2100 13,000 25 [23]

E. coli 55989S

. sonnei Ss046

E. coli B

L21 (DE

3)E

. coli BL21 (D

E3)

E. coli B

str. RE

L606E

. coli O103:H

2 str. 12009E

. coli E22 E

. coli CFT073S

. dysenteriae Sd197

E. coli 101-1

E. albertii TW

07627E

. coli B7A

E. coli O

26:H11 str. 11368

S. boydii C

DC

3083-94S

. flexneri 2a str. 301

790

707 S. boydii S

b227S

. flexneri 2a str. 2457TS

. flexneri 5 str. 8401E

. coli 536

510

221 E. coli E

110019

196

E. coli A

PE

C O

1E

. coli BL21 (D

E3)

87

E. coli E

D1a

E. coli S

88S

. dysenteriae 1012

500 E. coli O

127:H6 str. E

2348/69E

. coli SE

15E

. coli UTI89

E. fergusonii A

TCC

35469

493

124

E. coli F11

292 E. coli O

slo O103

383

494

377 E. coli K

12 str. ATC

C8739

E. coli H

SE

. coli IAI39

E. coli E

24377AE

. coli O111:H

- str. 11128E

. coli UM

N026

E. coli S

E11

E. coli S

MS

-3-5E

. coli O157:H

7 str. TW14588

E. coli O

157:H7 str. S

akaiE

. coli O157:H

7 str. EC

4401E

. coli O157:H

7 str. EC

4196E

. coli O157:H

7 str. EC

4115E

. coli O157:H

7 str. EC

4113E

. coli O157:H

7 str. EC

4076E

. coli O157:H

7 str. EC

4045E

. coli O157:H

7 str. EC

4042E

. coli IAI1

E. coli 53638E

. coli K12 str. B

W2952

E. coli K

12 str. DH

1E

. coli K12 str. D

H10B

E. coli K

12 str. MG

1655

272

E. coli K

12 str. W3110

E. coli O

157:H7 str. LA

NL E

CA

E. coli O

157:H7 str. E

C508

E. coli O

157:H7 str. LA

NL E

CF

E. coli O

157:H7 str. E

C4206

E. coli O

157:H7 str. E

C4486

E. coli O

157:H7 str. E

C4501

E. coli O

157:H7 str. E

C869

639

604 E. coli O

157:H7 str. E

DL933

225951

774

404

423

101

56

161

108

343

S. enterica Typhim

urium str. LT2

0.00516S rRNA tree of 60 E. coli genomes



epartment of S

ystems B


enmark

Manhattan Distance (# gene families)

gene family tree for 25 E. coli genomes

0.20 0.15 0.10 0.05 0.00

E. coli and Shigella, stabilome

Relative manhattan distance

!

! Shigella dysenteriae Sd197

!

!

! Shigella boydii Sb227

! Shigella boydii CDC3083 94

!

!

! Shigella flexneri5 8401

!

! Shigella flexneri2a 301

! Shigella flexneri2a 2457T

!

! Escherichia fergusonii ATCC35469

!

! Shigella sonnei Ss046

!

!

! Escherichia coli APECO1

!

! Escherichia coli O127H6 E2348 69

!

! Escherichia coli ED1a

!

! Escherichia coli CFT073

!

! Escherichia coli 536

!

! Escherichia coli S88

! Escherichia coli UTI89

!

! Escherichia coli IAI39

!

!

! Escherichia coli O157H7 EC4115

!

! Escherichia coli O157H7 TW14359

!

! Escherichia coli O157H7 Sakai

! Escherichia coli O157H7 EDL933

!

! Escherichia coli HS

!

!

!

! Escherichia coli ATCC8739

!

! Escherichia coli E24377A

!


!

! Escherichia coli SE11


!

! Escherichia coli SMS35

! Escherichia coli UMN026

!

!

!

! Escherichia coli BL21 DE3


!

! Escherichia coli B REL606

! Escherichia coli BL21

!

! Escherichia coli K12 DH10B

!

! Escherichia coli BW2952

!

! Escherichia coli K12 W3110

! Escherichia coli K12 MG1655

100

100

8568

100

100

95

83

95

74

47

47

74

100

97

96

68

43

85

43

39

43

22

100

36

99

35

55

95

100

100

85

66

53

72

0.15 0.10 0.05 0.00

E. coli and Shigella, mobilome


!

! Escherichia coli CFT073

!

!

! Escherichia coli O157H7 EC4115

!

! Escherichia coli O157H7 TW14359

!

! Escherichia coli O157H7 Sakai

! Escherichia coli O157H7 EDL933

!

!

! Escherichia coli UTI89

!

! Escherichia coli APECO1

! Escherichia coli S88

!

! Escherichia fergusonii ATCC35469

!

! Escherichia coli UMN026

!

! Escherichia coli SMS35

!

! Escherichia coli ED1a

!

! Escherichia coli E24377A

!

! Escherichia coli SE11

!

! Escherichia coli O127H6 E2348 69

!


!

! Shigella boydii CDC3083 94

!


!


!

! Shigella dysenteriae Sd197

!

! Escherichia coli HS

!

!

!

! Shigella flexneri2a 301

!

! Shigella flexneri2a 2457T

! Shigella flexneri5 8401

!

! Shigella boydii Sb227

! Shigella sonnei Ss046

!


!

! Escherichia coli ATCC8739

!

!

!

! Escherichia coli BW2952

! Escherichia coli K12 MG1655

!

! Escherichia coli K12 W3110

! Escherichia coli K12 DH10B

!

!



!

! Escherichia coli B REL606

! Escherichia coli BL21

100

99

90

90

98

98

9898

94

94

90

100

90

98

60

38

38

40

100

100

62

63

78

68

98

46

29

35

36

21

33

64

66

91

97

E. coli B7AE. coli E22E. coli E110019E. coli APECO1E. coli F11E. coli ED1aE. coli O127:H6 str. E2348/69E. coli 536E. coli SE15E. coli CFT073E. coli S88E. coli UTI89E. coli IAI39E. coli 53638E. coli UMN026

E. coli O103 Oslor. 11128

E. coli O103:H2 str. 12009E. coli O26:H11 str. 11368 E. coli E24377AE. coli 55989E. coli IAI1E. coli SE11E. coli HSE. coli BL21 (DE3 DOE)E. coli BL21 (DE3 AU)E. coli BL21 (DE3 Korea)E. coli B str. REL606E. coli K12 ATCC8739E. coli K12 DH10BE. coli K12 str. BW2952E. coli K12 str. DH1E. coli K12 str. MG1655E. coli K12 str. W3110E. coli O157:H7 str. EC4045E. coli O157:H7 str. LANL ECAE. coli O157:H7 str. LANL ECFE. coli O157:H7 str. TW14588E. coli O157:H7 str. SakaiE. coli O157:H7 str. EDL933E. coli O157:H7 str. EC4401E. coli O157:H7 str. EC4206E. coli O157:H7 str. EC869E. coli O157:H7 str. EC4486E. coli O157:H7 str. EC4042E. coli O157:H7 str. EC4115E. coli O157:H7 str. EC4076E. coli O157:H7 str. EC4501E. coli O157:H7 str. EC508E. coli O157:H7 str. EC4113E. coli O157:H7 str. EC4196

100

100

100

42

61

51

61

86

83

89

40

79

38

65

96

56

86

50

85

62

60

60

97

83

58

69

35

97

42

16

99

36

67

35

82

59

82

84

100

95

S. flexneri 5 str. 8401S. flexneri 2a str. 301S. flexneri 2a str. 2457TS. sonnei Ss046S. boydii Sb227

100

6060

00.050.001.051.002.0


S. dysenteriae Sd197S. dysenteriae 1012E. albertii TW07627 E. fergusonii ATCC 35469Salmonella enterica Typhimurium str. LT2

99

58

69

70

70

Pan-genome Family tree of 60 E. coli genomes



epartment of S

ystems B


enmark

0.30 0.25 0.20 0.15 0.10 0.05 0.00

Vibrio


!

!

! Aliivibrio salmonicida LFI1238

!

! Vibrio fischeri ES114

! Vibrio fischeri MJ11

!

!

!

!

! Vibrio cholerae V52

! Vibrio cholerae 2740!80

!

!

! Vibrio cholera O395 TEDA

!

! Vibrio cholera M66!2

! Vibrio cholerae N16961

!

!

! Vibrio cholera BX330286

!

! Vibrio cholera RC9

!

! Vibrio cholera MJ1236

! Vibrio cholera B33VCE

!

! Vibrio cholerae O395

! Vibrio cholerae MO10

!

!

! Vibrio cholera VL426

!

! Vibrio cholera TM11079!80

!

! Vibrio cholera 12129

! Vibrio cholera TMA21

!

! Vibrio cholerae MZO!2

!

! Vibrio cholerae AM!19226

! Vibrio cholerae 1587

!

!

!

!

! Vibrio parahaemolyticus RIMD2210633

! Vibrio sp Ex25

!

! Vibrio campbellii AND4

! Vibrio harveyi ATCC BAA1116

!

! Vibrio parahaemolyticus 16

!

! Vibrio vulnificus YJ016

! Vibrio vulnificus CMCP6

!

!

! Vibrio splendidus LGP32

! Vibrio sp MED222

!

! Photobacterium profundum SS9

! Vibrio shilonii AK1

10056

100

56

100

100

100

100

100

100

100

9797

88

77

100

87

62

62

98

100

100

100

100

98

91

76

80

67

79

79

0.20 0.15 0.10 0.05 0.00

Clostridium and friends


!

!

!

! Clostridium botulinum Bf! Clostridium botulinum Ba4 str 657, complete genome

!

! Clostridium botulinum A3 str Loch Maree

!

! Clostridium sporogenes ATCC 15579

!

!

! Clostridium botulinum A str ATCC 3502

!

! Clostridium botulinum A str ATCC 19397! Clostridium botulinum A str Hall

!

!

! Clostridium botulinum A2 str Kyoto! Clostridium botulinum NCTC 2916

!

! Clostridium botulinum F str Langeland! Clostridium botulinum B1 str Okra, complete genome

!

!

! Clostridium kluyveri NBRC 12016! Clostridium kluyveri DSM 555

!

!

!

! Clostridium butyricum 5521! Clostridium butyricum E4 str BoNT E BL5262

!

! Clostridium beijerinckii NCIMB 8052

!

! Clostridium botulinum B str Eklund 17B

!

! Clostridium botulinum E3 str Alaska E43! Clostridium botulinum E1 str 'BoNT E Beluga'

!

!

! Clostridium perfringens SM101

!

!

! Clostridium perfringens E str JGS1987

!

! Clostridium perfringens D str JGS1721! Clostridium perfringens B str ATCC 3626

!

! Clostridium perfringens C str JGS1495

!

! Clostridium perfringens str 13

!

! Clostridium perfringens ATCC 13124

!

! Clostridium perfringens NCTC 8239! Clostridium perfringens CPE str F4969

!

!

! Clostridium bolteae ATCC BAA!613! Clostridium asparagiforme DSM 15981

!

!

!

! Clostridium tetani E88

!

! Clostridium botulinum D str 1873

!

! Clostridium botulinum C str Eklund! Clostridium novyi NT

!

! Clostridium acetobutylicum ATCC 824! Clostridium cellulovorans 743B

!

!

! Clostridium nexile DSM 1787

!

! Clostridium scindens ATCC 35704! Clostridium hylemonae DSM 15053

!

!

! Clostridium spiroforme DSM 1552! Clostridium ramosum DSM 1402

!

!

! Clostridium hiranonis DSM 13275

!

! Clostridium bartlettii DSM 16795! Clostridium difficile 630

!

! Clostridium phytofermentans ISDg

!

!

! Clostridium cellulolyticum H10! Clostridium thermocellum ATCC 27405

!

!

! Clostridium leptum DSM 753! Clostridium methylpentosum DSM 5476

!

! Bacillus anthracis str Sterne! Escherichia coli str K!12 substr MG1655

100

100

100

100

79

100

79

100

100

100

84

93

55

7877

92

84

89

36

100

36

100

49

91

100

100

49

100

100

100

6464

100

100

100

100

100

100

84

100

84

75

100

75

100

80

100

100

100

100



epartment of S

ystems B


enmark

Questions:

● What is the difference between the core-genome and pan-genome?

●Where is the estimated size (roughly) of the E. coli pan-genome?

●How does the diversity of Clostridium genomes compare with that of other bacterial phyla?

pan- and core- genomes in bacteria - dtu …€¦ · comparative microbial genomics group center...

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