Bibliography PUBLISHED AND IN PRESS: 1. Palczewski, K., P.A. Hargrave, and M. Kochman, o–Phthalaldehyde, a fluorescence probe of aldolase

active site. Eur J Biochem, 1983. 137(3): p. 429–35. 2. Palczewski, K., P.A. Hargrave, E.J. Folta, and M. Kochman, Affinity labeling of rabbit muscle

fructose–1,6–bisphosphate aldolase with 5'–[p–(fluorosulfonyl)benzoyl]–1,N6–ethenoadenosine. Eur J Biochem, 1985. 146(2): p. 309–14.

3. Palczewski, K. and M. Kochman, Photoaffinity labeling of rabbit muscle fructose–1,6–bisphosphate aldolase with 8–azido–1,N6–ethenoadenosine 5'–triphosphate. Biochemistry, 1987. 26(12): p. 3466–71.

4. Palczewski, K., J.H. McDowell, and P.A. Hargrave, Purification and characterization of rhodopsin kinase. J Biol Chem, 1988. 263(28): p. 14067–73.

5. Palczewski, K., J.H. McDowell, and P.A. Hargrave, Rhodopsin kinase: substrate specificity and factors that influence activity. Biochemistry, 1988. 27(7): p. 2306–13.

6. Arendt, A., K. Palczewski, W.T. Moore, R.M. Caprioli, J.H. McDowell, and P.A. Hargrave, Synthesis of phosphopeptides containing O–phosphoserine or O–phosphothreonine. Int J Pept Protein Res, 1989. 33(6): p. 468–76.

7. Palczewski, K., A. Arendt, J.H. McDowell, and P.A. Hargrave, Substrate recognition determinants for rhodopsin kinase: studies with synthetic peptides, polyanions, and polycations. Biochemistry, 1989. 28(22): p. 8764–70.

8. Palczewski, K., P.A. Hargrave, J.H. McDowell, and T.S. Ingebritsen, The catalytic subunit of phosphatase 2A dephosphorylates phosphoopsin. Biochemistry, 1989. 28(2): p. 415–9.

9. Palczewski, K., J.H. McDowell, S. Jakes, T.S. Ingebritsen, and P.A. Hargrave, Regulation of rhodopsin dephosphorylation by arrestin. J Biol Chem, 1989. 264(27): p. 15770–3.

10. Fukada, Y., K. Kokame, T. Okano, Y. Shichida, T. Yoshizawa, J.H. McDowell, P.A. Hargrave, and K. Palczewski, Phosphorylation of iodopsin, chicken red–sensitive cone visual pigment. Biochemistry, 1990. 29(43): p. 10102–6.

11. Lebioda, L., P.A. Hargrave, and K. Palczewski, X–ray crystal structure of sangivamycin, a potent inhibitor of protein kinases. FEBS Lett, 1990. 266(1–2): p. 102–4.

12. Litchfield, D.W., A. Arendt, F.J. Lozeman, E.G. Krebs, P.A. Hargrave, and K. Palczewski, Synthetic phosphopeptides are substrates for casein kinase II. FEBS Lett, 1990. 261(1): p. 117–20.

13. Palczewski, K., M.E. Carruth, G. Adamus, J.H. McDowell, and P.A. Hargrave, Molecular, enzymatic and functional properties of rhodopsin kinase from rat pineal gland. Vision Res, 1990. 30(8): p. 1129–37.

14. Palczewski, K., N. Kahn, and P.A. Hargrave, Nucleoside inhibitors of rhodopsin kinase. Biochemistry, 1990. 29(26): p. 6276–82.

15. Adamus, G., Z.S. Zam, A. Arendt, K. Palczewski, J.H. McDowell, and P.A. Hargrave, Anti–rhodopsin monoclonal antibodies of defined specificity: characterization and application. Vision Res, 1991. 31(1): p. 17–31.

2

16. Buczylko, J., C. Gutmann, and K. Palczewski, Regulation of rhodopsin kinase by autophosphorylation. Proc Natl Acad Sci U S A, 1991. 88(6): p. 2568–72.

17. Lorenz, W., J. Inglese, K. Palczewski, J.J. Onorato, M.G. Caron, and R.J. Lefkowitz, The receptor kinase family: primary structure of rhodopsin kinase reveals similarities to the beta–adrenergic receptor kinase. Proc Natl Acad Sci U S A, 1991. 88(19): p. 8715–9.

18. Onorato, J.J., K. Palczewski, J.W. Regan, M.G. Caron, R.J. Lefkowitz, and J.L. Benovic, Role of acidic amino acids in peptide substrates of the beta–adrenergic receptor kinase and rhodopsin kinase. Biochemistry, 1991. 30(21): p. 5118–25.

19. Palczewski, K. and J.L. Benovic, G–protein–coupled receptor kinases. Trends Biochem Sci, 1991. 16(10): p. 387–91.

20. Palczewski, K., J. Buczylko, N.R. Imami, J.H. McDowell, and P.A. Hargrave, Role of the carboxyl–terminal region of arrestin in binding to phosphorylated rhodopsin. J Biol Chem, 1991. 266(23): p. 15334–9.

21. Palczewski, K., J. Buczylko, M.W. Kaplan, A.S. Polans, and J.W. Crabb, Mechanism of rhodopsin kinase activation. J Biol Chem, 1991. 266(20): p. 12949–55.

22. Palczewski, K., D.B. Farber, and P.A. Hargrave, Elevated level of protein phosphatase 2A activity in retinas of rd mice. Exp Eye Res, 1991. 53(1): p. 101–5.

23. Palczewski, K. and P.A. Hargrave, Studies of ligand binding to arrestin. J Biol Chem, 1991. 266(7): p. 4201–6.

24. Palczewski, K., A. Pulvermuller, J. Buczylko, C. Gutmann, and K.P. Hofmann, Binding of inositol phosphates to arrestin. FEBS Lett, 1991. 295(1–3): p. 195–9.

25. Palczewski, K., A. Pulvermuller, J. Buczylko, and K.P. Hofmann, Phosphorylated rhodopsin and heparin induce similar conformational changes in arrestin. J Biol Chem, 1991. 266(28): p. 18649–54.

26. Polans, A.S., J. Buczylko, J. Crabb, and K. Palczewski, A photoreceptor calcium binding protein is recognized by autoantibodies obtained from patients with cancer–associated retinopathy. J Cell Biol, 1991. 112(5): p. 981–9.

27. Ragazzi, E., J. Shryock, and K. Palczewski, Properties of solubilized and reconstituted A1 adenosine receptors from bovine brain. Pharmacol Res, 1991. 24(1): p. 15–23.

28. Hofmann, K.P., A. Pulvermuller, J. Buczylko, P. Van Hooser, and K. Palczewski, The role of arrestin and retinoids in the regeneration pathway of rhodopsin. J Biol Chem, 1992. 267(22): p. 15701–6.

29. Palczewski, K., J. Buczylko, P. Van Hooser, S.A. Carr, M.J. Huddleston, and J.W. Crabb, Identification of the autophosphorylation sites in rhodopsin kinase. J Biol Chem, 1992. 267(26): p. 18991–8.

30. Palczewski, K., J.H. Riazance–Lawrence, and W.C. Johnson, Jr., Structural properties of arrestin studied by chemical modification and circular dichroism. Biochemistry, 1992. 31(16): p. 3902–6.

31. Palczewski, K., G. Rispoli, and P.B. Detwiler, The influence of arrestin (48K protein) and rhodopsin kinase on visual transduction. Neuron, 1992. 8(1): p. 117–26.

32. Adamus, G., A. Arendt, P.A. Hargrave, T. Heyduk, and K. Palczewski, The kinetics of multiphosphorylation of rhodopsin. Arch Biochem Biophys, 1993. 304(2): p. 443–7.

33. Gray–Keller, M.P., A.S. Polans, K. Palczewski, and P.B. Detwiler, The effect of recoverin–like calcium–binding proteins on the photoresponse of retinal rods. Neuron, 1993. 10(3): p. 523–31.

3

34. Morrison, R.S., S. Giordano, F. Yamaguchi, S. Hendrickson, M.S. Berger, and K. Palczewski, Basic fibroblast growth factor expression is required for clonogenic growth of human glioma cells. J Neurosci Res, 1993. 34(5): p. 502–9.

35. Ohguro, H., S. Chiba, Y. Igarashi, H. Matsumoto, T. Akino, and K. Palczewski, Beta–arrestin and arrestin are recognized by autoantibodies in sera from multiple sclerosis patients. Proc Natl Acad Sci U S A, 1993. 90(8): p. 3241–5.

36. Ohguro, H., K. Palczewski, L.H. Ericsson, K.A. Walsh, and R.S. Johnson, Sequential phosphorylation of rhodopsin at multiple sites. Biochemistry, 1993. 32(21): p. 5718–24.

37. Palczewski, K., J. Buczylko, L. Lebioda, J.W. Crabb, and A.S. Polans, Identification of the N–terminal region in rhodopsin kinase involved in its interaction with rhodopsin. J Biol Chem, 1993. 268(8): p. 6004–13.

38. Polans, A.S., M.D. Burton, T.L. Haley, J.W. Crabb, and K. Palczewski, Recoverin, but not visinin, is an autoantigen in the human retina identified with a cancer–associated retinopathy. Invest Ophthalmol Vis Sci, 1993. 34(1): p. 81–90.

39. Pulvermuller, A., K. Palczewski, and K.P. Hofmann, Interaction between photoactivated rhodopsin and its kinase: stability and kinetics of complex formation. Biochemistry, 1993. 32(51): p. 14082–8.

40. Saari, J.C., D.L. Bredberg, G.G. Garwin, J. Buczylko, T. Wheeler, and K. Palczewski, Assays of retinoid dehydrogenases by phase partition. Anal Biochem, 1993. 213(1): p. 128–32.

41. Gorczyca, W.A., M.P. Gray–Keller, P.B. Detwiler, and K. Palczewski, Purification and physiological evaluation of a guanylate cyclase activating protein from retinal rods. Proc Natl Acad Sci U S A, 1994. 91(9): p. 4014–8.

42. Gorczyca, W.A., J.P. Van Hooser, and K. Palczewski, Nucleotide inhibitors and activators of retinal guanylyl cyclase. Biochemistry, 1994. 33(11): p. 3217–22.

43. Johnson, R.S., H. Ohguro, K. Palczewski, J.B. Hurley, K.A. Walsh, and T.A. Neubert, Heterogeneous N–acylation is a tissue– and species–specific posttranslational modification. J Biol Chem, 1994. 269(33): p. 21067–71.

44. Morrison, R.S., E. Shi, M. Kan, F. Yamaguchi, W. McKeehan, M. Rudnicka–Nawrot, and K. Palczewski, Inositolhexakisphosphate (InsP6): an antagonist of fibroblast growth factor receptor binding and activity. In Vitro Cell Dev Biol Anim, 1994. 30A(11): p. 783–9.

45. Ohguro, H., R.S. Johnson, L.H. Ericsson, K.A. Walsh, and K. Palczewski, Control of rhodopsin multiple phosphorylation. Biochemistry, 1994. 33(4): p. 1023–8.

46. Ohguro, H., K. Palczewski, K.A. Walsh, and R.S. Johnson, Topographic study of arrestin using differential chemical modifications and hydrogen/deuterium exchange. Protein Sci, 1994. 3(12): p. 2428–34.

47. Palczewski, K., Structure and functions of arrestins. Protein Sci, 1994. 3(9): p. 1355–61. 48. Palczewski, K., Is vertebrate phototransduction solved? New insights into the molecular mechanism

of phototransduction. Invest Ophthalmol Vis Sci, 1994. 35(10): p. 3577–81. 49. Palczewski, K., J. Buczylko, H. Ohguro, R.S. Annan, S.A. Carr, J.W. Crabb, M.W. Kaplan, R.S.

Johnson, and K.A. Walsh, Characterization of a truncated form of arrestin isolated from bovine rod outer segments. Protein Sci, 1994. 3(2): p. 314–24.

4

50. Palczewski, K., S. Jager, J. Buczylko, R.K. Crouch, D.L. Bredberg, K.P. Hofmann, M.A. Asson–Batres, and J.C. Saari, Rod outer segment retinol dehydrogenase: substrate specificity and role in phototransduction. Biochemistry, 1994. 33(46): p. 13741–50.

51. Palczewski, K., I. Subbaraya, W.A. Gorczyca, B.S. Helekar, C.C. Ruiz, H. Ohguro, J. Huang, X. Zhao, J.W. Crabb, R.S. Johnson, and et al., Molecular cloning and characterization of retinal photoreceptor guanylyl cyclase–activating protein. Neuron, 1994. 13(2): p. 395–404.

52. Polans, A.S., K. Palczewski, M.A. Asson–Batres, H. Ohguro, D. Witkowska, T.L. Haley, L. Baizer, and J.W. Crabb, Purification and primary structure of Capl, an S–100–related calcium–binding protein isolated from bovine retina. J Biol Chem, 1994. 269(8): p. 6233–40.

53. Robinson, P.R., J. Buczylko, H. Ohguro, and K. Palczewski, Opsins with mutations at the site of chromophore attachment constitutively activate transducin but are not phosphorylated by rhodopsin kinase. Proc Natl Acad Sci U S A, 1994. 91(12): p. 5411–5.

54. Smith, W.C., A.H. Milam, D. Dugger, A. Arendt, P.A. Hargrave, and K. Palczewski, A splice variant of arrestin. Molecular cloning and localization in bovine retina. J Biol Chem, 1994. 269(22): p. 15407–10.

55. Subbaraya, I., C.C. Ruiz, B.S. Helekar, X. Zhao, W.A. Gorczyca, M.J. Pettenati, P.N. Rao, K. Palczewski, and W. Baehr, Molecular characterization of human and mouse photoreceptor guanylate cyclase–activating protein (GCAP) and chromosomal localization of the human gene. J Biol Chem, 1994. 269(49): p. 31080–9.

56. Gorczyca, W.A., A.S. Polans, I.G. Surgucheva, I. Subbaraya, W. Baehr, and K. Palczewski, Guanylyl cyclase activating protein. A calcium–sensitive regulator of phototransduction. J Biol Chem, 1995. 270(37): p. 22029–36.

57. Kozak, C.A., M. Danciger, C. Bowes, M.C. Adamson, K. Palczewski, A.S. Polans, and D.B. Farber, Localization of three genes expressed in retina on mouse chromosome 11. Mamm Genome, 1995. 6(2): p. 142–4.

58. Ohguro, H. and K. Palczewski, Separation of phospho– and non–phosphopeptides using reverse phase column chromatography. FEBS Lett, 1995. 368(3): p. 452–4.

59. Ohguro, H., J.P. Van Hooser, A.H. Milam, and K. Palczewski, Rhodopsin phosphorylation and dephosphorylation in vivo. J Biol Chem, 1995. 270(24): p. 14259–62.

60. Palczewski, K., H. Ohguro, R.T. Premont, and J. Inglese, Rhodopsin kinase autophosphorylation. Characterization of site–specific mutations. J Biol Chem, 1995. 270(25): p. 15294–8.

61. Smith, W.C., G. Adamus, H. Van Der Wel, A. Timmers, K. Palczewski, R.J. Ulshafer, P.A. Hargrave, and J.H. McDowell, Alligator rhodopsin: sequence and biochemical properties. Exp Eye Res, 1995. 61(5): p. 569–78.

62. Zhao, X., K. Palczewski, and H. Ohguro, Mechanism of rhodopsin phosphorylation. Biophys Chem, 1995. 56(1–2): p. 183–8.

63. Buczylko, J., J.C. Saari, R.K. Crouch, and K. Palczewski, Mechanisms of opsin activation. J Biol Chem, 1996. 271(34): p. 20621–30.

64. Duda, T., R. Goraczniak, I. Surgucheva, M. Rudnicka–Nawrot, W.A. Gorczyca, K. Palczewski, A. Sitaramayya, W. Baehr, and R.K. Sharma, Calcium modulation of bovine photoreceptor guanylate cyclase. Biochemistry, 1996. 35(26): p. 8478–82.

65. Jager, S., K. Palczewski, and K.P. Hofmann, Opsin/all–trans–retinal complex activates transducin by different mechanisms than photolyzed rhodopsin. Biochemistry, 1996. 35(9): p. 2901–8.

5

66. Langlois, G., C.K. Chen, K. Palczewski, J.B. Hurley, and T.M. Vuong, Responses of the phototransduction cascade to dim light. Proc Natl Acad Sci U S A, 1996. 93(10): p. 4677–82.

67. Ohguro, H., M. Rudnicka–Nawrot, J. Buczylko, X. Zhao, J.A. Taylor, K.A. Walsh, and K. Palczewski, Structural and enzymatic aspects of rhodopsin phosphorylation. J Biol Chem, 1996. 271(9): p. 5215–24.

68. Palczewski, K. and W.C. Smith, Splice variants of arrestins. Exp Eye Res, 1996. 63(5): p. 599–602. 69. Polans, A., W. Baehr, and K. Palczewski, Turned on by Ca2+! The physiology and pathology of

Ca2+–binding proteins in the retina. Trends Neurosci, 1996. 19(12): p. 547–54. 70. Semple–Rowland, S.L., W.A. Gorczyca, J. Buczylko, B.S. Helekar, C.C. Ruiz, I. Subbaraya, K.

Palczewski, and W. Baehr, Expression of GCAP1 and GCAP2 in the retinal degeneration (rd) mutant chicken retina. FEBS Lett, 1996. 385(1–2): p. 47–52.

71. Johnson, W.C., Jr., K. Palczewski, W.A. Gorczyca, J.H. Riazance–Lawrence, D. Witkowska, and A.S. Polans, Calcium binding to recoverin: implications for secondary structure and membrane association. Biochim Biophys Acta, 1997. 1342(2): p. 164–74.

72. Otto–Bruc, A., J. Buczylko, I. Surgucheva, I. Subbaraya, M. Rudnicka–Nawrot, J.W. Crabb, A. Arendt, P.A. Hargrave, W. Baehr, and K. Palczewski, Functional reconstitution of photoreceptor guanylate cyclase with native and mutant forms of guanylate cyclase–activating protein 1. Biochemistry, 1997. 36(14): p. 4295–302.

73. Otto–Bruc, A., R.N. Fariss, F. Haeseleer, J. Huang, J. Buczylko, I. Surgucheva, W. Baehr, A.H. Milam, and K. Palczewski, Localization of guanylate cyclase–activating protein 2 in mammalian retinas. Proc Natl Acad Sci U S A, 1997. 94(9): p. 4727–32.

74. Palczewski, K., GTP–binding–protein–coupled receptor kinases––two mechanistic models. Eur J Biochem, 1997. 248(2): p. 261–9.

75. Palczewski, K. and J.C. Saari, Activation and inactivation steps in the visual transduction pathway. Curr Opin Neurobiol, 1997. 7(4): p. 500–4.

76. Pulvermuller, A., D. Maretzki, M. Rudnicka–Nawrot, W.C. Smith, K. Palczewski, and K.P. Hofmann, Functional differences in the interaction of arrestin and its splice variant, p44, with rhodopsin. Biochemistry, 1997. 36(30): p. 9253–60.

77. Surguchov, A., J.D. Bronson, P. Banerjee, J.A. Knowles, C. Ruiz, I. Subbaraya, K. Palczewski, and W. Baehr, The human GCAP1 and GCAP2 genes are arranged in a tail–to–tail array on the short arm of chromosome 6 (p21.1). Genomics, 1997. 39(3): p. 312–22.

78. Zhao, X., F. Haeseleer, R.N. Fariss, J. Huang, W. Baehr, A.H. Milam, and K. Palczewski, Molecular cloning and localization of rhodopsin kinase in the mammalian pineal. Vis Neurosci, 1997. 14(2): p. 225–32.

79. Cideciyan, A.V., X. Zhao, L. Nielsen, S.C. Khani, S.G. Jacobson, and K. Palczewski, Null mutation in the rhodopsin kinase gene slows recovery kinetics of rod and cone phototransduction in man. Proc Natl Acad Sci U S A, 1998. 95(1): p. 328–33.

80. Cowan, C.W., R.N. Fariss, I. Sokal, K. Palczewski, and T.G. Wensel, High expression levels in cones of RGS9, the predominant GTPase accelerating protein of rods. Proc Natl Acad Sci U S A, 1998. 95(9): p. 5351–6.

81. Haeseleer, F., J. Huang, L. Lebioda, J.C. Saari, and K. Palczewski, Molecular characterization of a novel short–chain dehydrogenase/reductase that reduces all–trans–retinal. J Biol Chem, 1998. 273(34): p. 21790–9.

6

82. Li, N., R.N. Fariss, K. Zhang, A. Otto–Bruc, F. Haeseleer, D. Bronson, N. Qin, A. Yamazaki, I. Subbaraya, A.H. Milam, K. Palczewski, and W. Baehr, Guanylate–cyclase–inhibitory protein is a frog retinal Ca2+–binding protein related to mammalian guanylate–cyclase–activating proteins. Eur J Biochem, 1998. 252(3): p. 591–9.

83. Moon, C., P. Jaberi, A. Otto–Bruc, W. Baehr, K. Palczewski, and G.V. Ronnett, Calcium–sensitive particulate guanylyl cyclase as a modulator of cAMP in olfactory receptor neurons. J Neurosci, 1998. 18(9): p. 3195–205.

84. Ohguro, H., N. Yoshida, H. Shindou, J.W. Crabb, K. Palczewski, and M. Tsuda, Identification of a single phosphorylation site within octopus rhodopsin. Photochem Photobiol, 1998. 68(6): p. 824–8.

85. Otto–Bruc, A.E., R.N. Fariss, J.P. Van Hooser, and K. Palczewski, Phosphorylation of photolyzed rhodopsin is calcium–insensitive in retina permeabilized by alpha–toxin. Proc Natl Acad Sci U S A, 1998. 95(25): p. 15014–9.

86. Rudnicka–Nawrot, M., I. Surgucheva, J.D. Hulmes, F. Haeseleer, I. Sokal, J.W. Crabb, W. Baehr, and K. Palczewski, Changes in biological activity and folding of guanylate cyclase–activating protein 1 as a function of calcium. Biochemistry, 1998. 37(1): p. 248–57.

87. Saari, J.C., G.G. Garwin, J.P. Van Hooser, and K. Palczewski, Reduction of all–trans–retinal limits regeneration of visual pigment in mice. Vision Res, 1998. 38(10): p. 1325–33.

88. Semple–Rowland, S.L., N.R. Lee, J.P. Van Hooser, K. Palczewski, and W. Baehr, A null mutation in the photoreceptor guanylate cyclase gene causes the retinal degeneration chicken phenotype. Proc Natl Acad Sci U S A, 1998. 95(3): p. 1271–6.

89. Sokal, I., N. Li, I. Surgucheva, M.J. Warren, A.M. Payne, S.S. Bhattacharya, W. Baehr, and K. Palczewski, GCAP1 (Y99C) mutant is constitutively active in autosomal dominant cone dystrophy. Mol Cell, 1998. 2(1): p. 129–33.

90. Zhao, X., J. Huang, S.C. Khani, and K. Palczewski, Molecular forms of human rhodopsin kinase (GRK1). J Biol Chem, 1998. 273(9): p. 5124–31.

91. Ames, J.B., A.M. Dizhoor, M. Ikura, K. Palczewski, and L. Stryer, Three–dimensional structure of guanylyl cyclase activating protein–2, a calcium–sensitive modulator of photoreceptor guanylyl cyclases. J Biol Chem, 1999. 274(27): p. 19329–37.

92. Haeseleer, F., I. Sokal, N. Li, M. Pettenati, N. Rao, D. Bronson, R. Wechter, W. Baehr, and K. Palczewski, Molecular characterization of a third member of the guanylyl cyclase–activating protein subfamily. J Biol Chem, 1999. 274(10): p. 6526–35.

93. Mukherjee, S., K. Palczewski, V. Gurevich, J.L. Benovic, J.P. Banga, and M. Hunzicker–Dunn, A direct role for arrestins in desensitization of the luteinizing hormone/choriogonadotropin receptor in porcine ovarian follicular membranes. Proc Natl Acad Sci U S A, 1999. 96(2): p. 493–8.

94. Mukherjee, S., K. Palczewski, V.V. Gurevich, and M. Hunzicker–Dunn, beta–arrestin–dependent desensitization of luteinizing hormone/choriogonadotropin receptor is prevented by a synthetic peptide corresponding to the third intracellular loop of the receptor. J Biol Chem, 1999. 274(19): p. 12984–9.

95. Palczewski, K., J.P. Van Hooser, G.G. Garwin, J. Chen, G.I. Liou, and J.C. Saari, Kinetics of visual pigment regeneration in excised mouse eyes and in mice with a targeted disruption of the gene encoding interphotoreceptor retinoid–binding protein or arrestin. Biochemistry, 1999. 38(37): p. 12012–9.

7

96. Palczewski, K., C.L. Verlinde, and F. Haeseleer, Molecular mechanism of visual transduction. Novartis Found Symp, 1999. 224: p. 191–204; discussion 204–7.

97. Sokal, I., F. Haeseleer, A. Arendt, E.T. Adman, P.A. Hargrave, and K. Palczewski, Identification of a guanylyl cyclase–activating protein–binding site within the catalytic domain of retinal guanylyl cyclase 1. Biochemistry, 1999. 38(5): p. 1387–93.

98. Sokal, I., A.E. Otto–Bruc, I. Surgucheva, C.L. Verlinde, C.K. Wang, W. Baehr, and K. Palczewski, Conformational changes in guanylyl cyclase–activating protein 1 (GCAP1) and its tryptophan mutants as a function of calcium concentration. J Biol Chem, 1999. 274(28): p. 19829–37.

99. Stecher, H., M.H. Gelb, J.C. Saari, and K. Palczewski, Preferential release of 11–cis–retinol from retinal pigment epithelial cells in the presence of cellular retinaldehyde–binding protein. J Biol Chem, 1999. 274(13): p. 8577–85.

100. Stecher, H., O. Prezhdo, J. Das, R.K. Crouch, and K. Palczewski, Isomerization of all–trans–9– and 13–desmethylretinol by retinal pigment epithelial cells. Biochemistry, 1999. 38(41): p. 13542–50.

101. Wolbring, G., W. Baehr, K. Palczewski, and P.P. Schnetkamp, Light inhibition of bovine retinal rod guanylyl cyclase mediated by beta gamma–transducin. Biochemistry, 1999. 38(9): p. 2611–6.

102. Zhang, K., K.A. Howes, W. He, J.D. Bronson, M.J. Pettenati, C. Chen, K. Palczewski, T.G. Wensel, and W. Baehr, Structure, alternative splicing, and expression of the human RGS9 gene. Gene, 1999. 240(1): p. 23–34.

103. Zhao, X., K. Yokoyama, M.E. Whitten, J. Huang, M.H. Gelb, and K. Palczewski, A novel form of rhodopsin kinase from chicken retina and pineal gland. FEBS Lett, 1999. 454(1–2): p. 115–21.

104. Cideciyan, A.V., F. Haeseleer, R.N. Fariss, T.S. Aleman, G.F. Jang, C.L. Verlinde, M.F. Marmor, S.G. Jacobson, and K. Palczewski, Rod and cone visual cycle consequences of a null mutation in the 11–cis–retinol dehydrogenase gene in man. Vis Neurosci, 2000. 17(5): p. 667–78.

105. Driessen, C.A., H.J. Winkens, K. Hoffmann, L.D. Kuhlmann, B.P. Janssen, A.H. Van Vugt, J.P. Van Hooser, B.E. Wieringa, A.F. Deutman, K. Palczewski, K. Ruether, and J.J. Janssen, Disruption of the 11–cis–retinol dehydrogenase gene leads to accumulation of cis–retinols and cis–retinyl esters. Mol Cell Biol, 2000. 20(12): p. 4275–87.

106. Haeseleer, F. and K. Palczewski, Short–chain dehydrogenases/reductases in retina. Methods Enzymol, 2000. 316: p. 372–83.

107. Haeseleer, F., I. Sokal, C.L. Verlinde, H. Erdjument–Bromage, P. Tempst, A.N. Pronin, J.L. Benovic, R.N. Fariss, and K. Palczewski, Five members of a novel Ca2+–binding protein (CABP) subfamily with similarity to calmodulin. J Biol Chem, 2000. 275(2): p. 1247–60.

108. Imamoto, Y., M. Kataoka, F. Tokunaga, and K. Palczewski, Light–induced conformational changes of rhodopsin probed by fluorescent alexa594 immobilized on the cytoplasmic surface. Biochemistry, 2000. 39(49): p. 15225–33.

109. Jang, G.F., J.K. McBee, A.M. Alekseev, F. Haeseleer, and K. Palczewski, Stereoisomeric specificity of the retinoid cycle in the vertebrate retina. J Biol Chem, 2000. 275(36): p. 28128–38.

110. McBee, J.K., V. Kuksa, R. Alvarez, A.R. de Lera, O. Prezhdo, F. Haeseleer, I. Sokal, and K. Palczewski, Isomerization of all–trans–retinol to cis–retinols in bovine retinal pigment epithelial cells: dependence on the specificity of retinoid–binding proteins. Biochemistry, 2000. 39(37): p. 11370–80.

111. Mukherjee, S., V.V. Gurevich, J.C. Jones, J.E. Casanova, S.R. Frank, E.T. Maizels, M.F. Bader, R.A. Kahn, K. Palczewski, K. Aktories, and M. Hunzicker–Dunn, The ADP ribosylation factor

8

nucleotide exchange factor ARNO promotes beta–arrestin release necessary for luteinizing hormone/choriogonadotropin receptor desensitization. Proc Natl Acad Sci U S A, 2000. 97(11): p. 5901–6.

112. Okada, T., I. Le Trong, B.A. Fox, C.A. Behnke, R.E. Stenkamp, and K. Palczewski, X–Ray diffraction analysis of three–dimensional crystals of bovine rhodopsin obtained from mixed micelles. J Struct Biol, 2000. 130(1): p. 73–80.

113. Palczewski, K., T. Kumasaka, T. Hori, C.A. Behnke, H. Motoshima, B.A. Fox, I. Le Trong, D.C. Teller, T. Okada, R.E. Stenkamp, M. Yamamoto, and M. Miyano, Crystal structure of rhodopsin: A G protein–coupled receptor. Science, 2000. 289(5480): p. 739–45.

114. Palczewski, K., A.S. Polans, W. Baehr, and J.B. Ames, Ca2+–binding proteins in the retina: structure, function, and the etiology of human visual diseases. Bioessays, 2000. 22(4): p. 337–50.

115. Saari, J.C., G.G. Garwin, F. Haeseleer, G.F. Jang, and K. Palczewski, Phase partition and high–performance liquid chromatography assays of retinoid dehydrogenases. Methods Enzymol, 2000. 316: p. 359–71.

116. Sokal, I., N. Li, C.L. Verlinde, F. Haeseleer, W. Baehr, and K. Palczewski, Ca2+–binding proteins in the retina: from discovery to etiology of human disease(1). Biochim Biophys Acta, 2000. 1498(2–3): p. 233–51.

117. Stecher, H. and K. Palczewski, Multienzyme analysis of visual cycle. Methods Enzymol, 2000. 316: p. 330–44.

118. Van Hooser, J.P., T.S. Aleman, Y.G. He, A.V. Cideciyan, V. Kuksa, S.J. Pittler, E.M. Stone, S.G. Jacobson, and K. Palczewski, Rapid restoration of visual pigment and function with oral retinoid in a mouse model of childhood blindness. Proc Natl Acad Sci U S A, 2000. 97(15): p. 8623–8.

119. Whitten, M.E., K. Yokoyama, D. Schieltz, F. Ghomashchi, D. Lam, J.R. Yates, 3rd, K. Palczewski, and M.H. Gelb, Structural analysis of protein prenyl groups and associated C–terminal modifications. Methods Enzymol, 2000. 316: p. 436–51.

120. Ballesteros, J. and K. Palczewski, G protein–coupled receptor drug discovery: implications from the crystal structure of rhodopsin. Curr Opin Drug Discov Devel, 2001. 4(5): p. 561–74.

121. Brereton, P., T. Suzuki, H. Sasano, K. Li, C. Duarte, V. Obeyesekere, F. Haeseleer, K. Palczewski, I. Smith, P. Komesaroff, and Z. Krozowski, Pan1b (17betaHSD11)–enzymatic activity and distribution in the lung. Mol Cell Endocrinol, 2001. 171(1–2): p. 111–7.

122. Haeseleer, F., Y. Imanishi, D.A. Saperstein, and K. Palczewski, Gene transfer mediated by recombinant baculovirus into mouse eye. Invest Ophthalmol Vis Sci, 2001. 42(13): p. 3294–300.

123. Hu, G., G.F. Jang, C.W. Cowan, T.G. Wensel, and K. Palczewski, Phosphorylation of RGS9–1 by an endogenous protein kinase in rod outer segments. J Biol Chem, 2001. 276(25): p. 22287–95.

124. Jang, G.F., V. Kuksa, S. Filipek, F. Bartl, E. Ritter, M.H. Gelb, K.P. Hofmann, and K. Palczewski, Mechanism of rhodopsin activation as examined with ring–constrained retinal analogs and the crystal structure of the ground state protein. J Biol Chem, 2001. 276(28): p. 26148–53.

125. Jang, G.F., J.P. Van Hooser, V. Kuksa, J.K. McBee, Y.G. He, J.J. Janssen, C.A. Driessen, and K. Palczewski, Characterization of a dehydrogenase activity responsible for oxidation of 11–cis–retinol in the retinal pigment epithelium of mice with a disrupted RDH5 gene. A model for the human hereditary disease fundus albipunctatus. J Biol Chem, 2001. 276(35): p. 32456–65.

9

126. Li, N., I. Sokal, J.D. Bronson, K. Palczewski, and W. Baehr, Identification of functional regions of guanylate cyclase–activating protein 1 (GCAP1) using GCAP1/GCIP chimeras. Biol Chem, 2001. 382(8): p. 1179–88.

127. McBee, J.K., K. Palczewski, W. Baehr, and D.R. Pepperberg, Confronting complexity: the interlink of phototransduction and retinoid metabolism in the vertebrate retina. Prog Retin Eye Res, 2001. 20(4): p. 469–529.

128. McBee, J.K., J.P. Van Hooser, G.F. Jang, and K. Palczewski, Isomerization of 11–cis–retinoids to all–trans–retinoids in vitro and in vivo. J Biol Chem, 2001. 276(51): p. 48483–93.

129. Mendez, A., M.E. Burns, I. Sokal, A.M. Dizhoor, W. Baehr, K. Palczewski, D.A. Baylor, and J. Chen, Role of guanylate cyclase–activating proteins (GCAPs) in setting the flash sensitivity of rod photoreceptors. Proc Natl Acad Sci U S A, 2001. 98(17): p. 9948–53.

130. Okada, T., O.P. Ernst, K. Palczewski, and K.P. Hofmann, Activation of rhodopsin: new insights from structural and biochemical studies. Trends Biochem Sci, 2001. 26(5): p. 318–24.

131. Okada, T. and K. Palczewski, Crystal structure of rhodopsin: implications for vision and beyond. Curr Opin Struct Biol, 2001. 11(4): p. 420–6.

132. Sokal, I., N. Li, C.S. Klug, S. Filipek, W.L. Hubbell, W. Baehr, and K. Palczewski, Calcium–sensitive regions of GCAP1 as observed by chemical modifications, fluorescence, and EPR spectroscopies. J Biol Chem, 2001. 276(46): p. 43361–73.

133. Teller, D.C., T. Okada, C.A. Behnke, K. Palczewski, and R.E. Stenkamp, Advances in determination of a high–resolution three–dimensional structure of rhodopsin, a model of G–protein–coupled receptors (GPCRs). Biochemistry, 2001. 40(26): p. 7761–72.

134. Yan, W., G.F. Jang, F. Haeseleer, N. Esumi, J. Chang, M. Kerrigan, M. Campochiaro, P. Campochiaro, K. Palczewski, and D.J. Zack, Cloning and characterization of a human beta,beta–carotene–15,15'–dioxygenase that is highly expressed in the retinal pigment epithelium. Genomics, 2001. 72(2): p. 193–202.

135. Haeseleer, F., Y. Imanishi, I. Sokal, S. Filipek, and K. Palczewski, Calcium–binding proteins: intracellular sensors from the calmodulin superfamily. Biochem Biophys Res Commun, 2002. 290(2): p. 615–23.

136. Haeseleer, F., G.F. Jang, Y. Imanishi, C.A. Driessen, M. Matsumura, P.S. Nelson, and K. Palczewski, Dual–substrate specificity short chain retinol dehydrogenases from the vertebrate retina. J Biol Chem, 2002. 277(47): p. 45537–46.

137. Haeseleer, F. and K. Palczewski, Calmodulin and Ca2+–binding proteins (CaBPs): variations on a theme. Adv Exp Med Biol, 2002. 514: p. 303–17.

138. Howes, K.A., M.E. Pennesi, I. Sokal, J. Church–Kopish, B. Schmidt, D. Margolis, J.M. Frederick, F. Rieke, K. Palczewski, S.M. Wu, P.B. Detwiler, and W. Baehr, GCAP1 rescues rod photoreceptor response in GCAP1/GCAP2 knockout mice. EMBO J, 2002. 21(7): p. 1545–54.

139. Imanishi, Y., N. Li, I. Sokal, M.E. Sowa, O. Lichtarge, T.G. Wensel, D.A. Saperstein, W. Baehr, and K. Palczewski, Characterization of retinal guanylate cyclase–activating protein 3 (GCAP3) from zebrafish to man. Eur J Neurosci, 2002. 15(1): p. 63–78.

140. Kuksa, V., F. Bartl, T. Maeda, G.F. Jang, E. Ritter, M. Heck, J.P. Van Hooser, Y. Liang, S. Filipek, M.H. Gelb, K.P. Hofmann, and K. Palczewski, Biochemical and physiological properties of rhodopsin regenerated with 11–cis–6–ring– and 7–ring–retinals. J Biol Chem, 2002. 277(44): p. 42315–24.

10

141. Lee, A., R.E. Westenbroek, F. Haeseleer, K. Palczewski, T. Scheuer, and W.A. Catterall, Differential modulation of Ca(v)2.1 channels by calmodulin and Ca2+–binding protein 1. Nat Neurosci, 2002. 5(3): p. 210–7.

142. Maeda, A., T. Maeda, H. Ohguro, K. Palczewski, and N. Sato, Vaccination with recoverin, a cancer–associated retinopathy antigen, induces autoimmune retinal dysfunction and tumor cell regression in mice. Eur J Immunol, 2002. 32(8): p. 2300–7.

143. Sokal, I., A. Alekseev, W. Baehr, F. Haeseleer, and K. Palczewski, Soluble fusion proteins between single transmembrane photoreceptor guanylyl cyclases and their activators. Biochemistry, 2002. 41(1): p. 251–7.

144. Sokal, I., A. Pulvermuller, J. Buczylko, K.P. Hofmann, and K. Palczewski, Rhodopsin and its kinase. Methods Enzymol, 2002. 343: p. 578–600.

145. Stenkamp, R.E., S. Filipek, C.A. Driessen, D.C. Teller, and K. Palczewski, Crystal structure of rhodopsin: a template for cone visual pigments and other G protein–coupled receptors. Biochim Biophys Acta, 2002. 1565(2): p. 168–82.

146. Stenkamp, R.E., D.C. Teller, and K. Palczewski, Crystal structure of rhodopsin: a G–protein–coupled receptor. Chembiochem, 2002. 3(10): p. 963–7.

147. Van Hooser, J.P., Y. Liang, T. Maeda, V. Kuksa, G.F. Jang, Y.G. He, F. Rieke, H.K. Fong, P.B. Detwiler, and K. Palczewski, Recovery of visual functions in a mouse model of Leber congenital amaurosis. J Biol Chem, 2002. 277(21): p. 19173–82.

148. Yang, J., S. McBride, D.O. Mak, N. Vardi, K. Palczewski, F. Haeseleer, and J.K. Foskett, Identification of a family of calcium sensors as protein ligands of inositol trisphosphate receptor Ca2+ release channels. Proc Natl Acad Sci U S A, 2002. 99(11): p. 7711–6.

149. Baehr, W., S.M. Wu, A.C. Bird, and K. Palczewski, The retinoid cycle and retina disease. Vision Res, 2003. 43(28): p. 2957–8.

150. Driessen, C., H. Winkens, F. Haeseleer, K. Palczewski, and J. Janssen, Novel targeting strategy for generating mouse models with defects in the retinoid cycle. Vision Res, 2003. 43(28): p. 3075–9.

151. Filipek, S., R.E. Stenkamp, D.C. Teller, and K. Palczewski, G protein–coupled receptor rhodopsin: a prospectus. Annu Rev Physiol, 2003. 65: p. 851–79.

152. Filipek, S., D.C. Teller, K. Palczewski, and R. Stenkamp, The crystallographic model of rhodopsin and its use in studies of other G protein–coupled receptors. Annu Rev Biophys Biomol Struct, 2003. 32: p. 375–97.

153. Fotiadis, D., Y. Liang, S. Filipek, D.A. Saperstein, A. Engel, and K. Palczewski, Atomic–force microscopy: Rhodopsin dimers in native disc membranes. Nature, 2003. 421(6919): p. 127–8.

154. Fritze, O., S. Filipek, V. Kuksa, K. Palczewski, K.P. Hofmann, and O.P. Ernst, Role of the conserved NPxxY(x)5,6F motif in the rhodopsin ground state and during activation. Proc Natl Acad Sci U S A, 2003. 100(5): p. 2290–5.

155. Heck, M., S.A. Schadel, D. Maretzki, F.J. Bartl, E. Ritter, K. Palczewski, and K.P. Hofmann, Signaling states of rhodopsin. Formation of the storage form, metarhodopsin III, from active metarhodopsin II. J Biol Chem, 2003. 278(5): p. 3162–9.

156. Kuksa, V., Y. Imanishi, M. Batten, K. Palczewski, and A.R. Moise, Retinoid cycle in the vertebrate retina: experimental approaches and mechanisms of isomerization. Vision Res, 2003. 43(28): p. 2959–81.

11

157. Liang, Y., D. Fotiadis, S. Filipek, D.A. Saperstein, K. Palczewski, and A. Engel, Organization of the G protein–coupled receptors rhodopsin and opsin in native membranes. J Biol Chem, 2003. 278(24): p. 21655–62.

158. Maeda, T., Y. Imanishi, and K. Palczewski, Rhodopsin phosphorylation: 30 years later. Prog Retin Eye Res, 2003. 22(4): p. 417–34.

159. Maeda, T., J.P. Van Hooser, C.A. Driessen, S. Filipek, J.J. Janssen, and K. Palczewski, Evaluation of the role of the retinal G protein–coupled receptor (RGR) in the vertebrate retina in vivo. J Neurochem, 2003. 85(4): p. 944–56.

160. Marmor, M.F., F. Haeseleer, and K. Palczewski, Albipunctate retinopathy with cone dysfunction and no abnormality in the RDH5 or RLBP1 genes. Retina, 2003. 23(4): p. 543–6.

161. Mirzadegan, T., G. Benko, S. Filipek, and K. Palczewski, Sequence analyses of G–protein–coupled receptors: similarities to rhodopsin. Biochemistry, 2003. 42(10): p. 2759–67.

162. Noorwez, S.M., V. Kuksa, Y. Imanishi, L. Zhu, S. Filipek, K. Palczewski, and S. Kaushal, Pharmacological chaperone–mediated in vivo folding and stabilization of the P23H–opsin mutant associated with autosomal dominant retinitis pigmentosa. J Biol Chem, 2003. 278(16): p. 14442–50.

163. Ridge, K.D., N.G. Abdulaev, M. Sousa, and K. Palczewski, Phototransduction: crystal clear. Trends Biochem Sci, 2003. 28(9): p. 479–87.

164. Schadel, S.A., M. Heck, D. Maretzki, S. Filipek, D.C. Teller, K. Palczewski, and K.P. Hofmann, Ligand channeling within a G–protein–coupled receptor. The entry and exit of retinals in native opsin. J Biol Chem, 2003. 278(27): p. 24896–903.

165. Sokal, I., A. Alekseev, and K. Palczewski, Photoreceptor guanylate cyclase variants: cGMP production under control. Acta Biochim Pol, 2003. 50(4): p. 1075–95.

166. Sokal, I., G. Hu, Y. Liang, M. Mao, T.G. Wensel, and K. Palczewski, Identification of protein kinase C isozymes responsible for the phosphorylation of photoreceptor–specific RGS9–1 at Ser475. J Biol Chem, 2003. 278(10): p. 8316–25.

167. Teller, D.C., R.E. Stenkamp, and K. Palczewski, Evolutionary analysis of rhodopsin and cone pigments: connecting the three–dimensional structure with spectral tuning and signal transfer. FEBS Lett, 2003. 555(1): p. 151–9.

168. Aleman, T.S., S.G. Jacobson, J.D. Chico, M.L. Scott, A.Y. Cheung, E.A. Windsor, M. Furushima, T.M. Redmond, J. Bennett, K. Palczewski, and A.V. Cideciyan, Impairment of the transient pupillary light reflex in Rpe65(–/–) mice and humans with leber congenital amaurosis. Invest Ophthalmol Vis Sci, 2004. 45(4): p. 1259–71.

169. Batten, M.L., Y. Imanishi, T. Maeda, D.C. Tu, A.R. Moise, D. Bronson, D. Possin, R.N. Van Gelder, W. Baehr, and K. Palczewski, Lecithin–retinol acyltransferase is essential for accumulation of all–trans–retinyl esters in the eye and in the liver. J Biol Chem, 2004. 279(11): p. 10422–32.

170. Filipek, S., K.A. Krzysko, D. Fotiadis, Y. Liang, D.A. Saperstein, A. Engel, and K. Palczewski, A concept for G protein activation by G protein–coupled receptor dimers: the transducin/rhodopsin interface. Photochem Photobiol Sci, 2004. 3(6): p. 628–38.

171. Fotiadis, D., Y. Liang, S. Filipek, D.A. Saperstein, A. Engel, and K. Palczewski, The G protein–coupled receptor rhodopsin in the native membrane. FEBS Lett, 2004. 564(3): p. 281–8.

12

172. Haeseleer, F., Y. Imanishi, T. Maeda, D.E. Possin, A. Maeda, A. Lee, F. Rieke, and K. Palczewski, Essential role of Ca2+–binding protein 4, a Cav1.4 channel regulator, in photoreceptor synaptic function. Nat Neurosci, 2004. 7(10): p. 1079–87.

173. Imanishi, Y., M.L. Batten, D.W. Piston, W. Baehr, and K. Palczewski, Noninvasive two–photon imaging reveals retinyl ester storage structures in the eye. J Cell Biol, 2004. 164(3): p. 373–83.

174. Imanishi, Y., V. Gerke, and K. Palczewski, Retinosomes: new insights into intracellular managing of hydrophobic substances in lipid bodies. J Cell Biol, 2004. 166(4): p. 447–53.

175. Imanishi, Y., L. Yang, I. Sokal, S. Filipek, K. Palczewski, and W. Baehr, Diversity of guanylate cyclase–activating proteins (GCAPs) in teleost fish: characterization of three novel GCAPs (GCAP4, GCAP5, GCAP7) from zebrafish (Danio rerio) and prediction of eight GCAPs (GCAP1–8) in pufferfish (Fugu rubripes). J Mol Evol, 2004. 59(2): p. 204–17.

176. Jastrzebska, B., T. Maeda, L. Zhu, D. Fotiadis, S. Filipek, A. Engel, R.E. Stenkamp, and K. Palczewski, Functional characterization of rhodopsin monomers and dimers in detergents. J Biol Chem, 2004. 279(52): p. 54663–75.

177. Liang, Y., D. Fotiadis, T. Maeda, A. Maeda, A. Modzelewska, S. Filipek, D.A. Saperstein, A. Engel, and K. Palczewski, Rhodopsin signaling and organization in heterozygote rhodopsin knockout mice. J Biol Chem, 2004. 279(46): p. 48189–96.

178. Mammen, A., P.J. Simpson, A. Nighorn, Y. Imanishi, K. Palczewski, G.V. Ronnett, and C. Moon, Hippocalcin in the olfactory epithelium: a mediator of second messenger signaling. Biochem Biophys Res Commun, 2004. 322(4): p. 1131–9.

179. Moise, A.R., V. Kuksa, Y. Imanishi, and K. Palczewski, Identification of all–trans–retinol:all–trans–13,14–dihydroretinol saturase. J Biol Chem, 2004. 279(48): p. 50230–42.

180. Nishiguchi, K.M., I. Sokal, L. Yang, N. Roychowdhury, K. Palczewski, E.L. Berson, T.P. Dryja, and W. Baehr, A novel mutation (I143NT) in guanylate cyclase–activating protein 1 (GCAP1) associated with autosomal dominant cone degeneration. Invest Ophthalmol Vis Sci, 2004. 45(11): p. 3863–70.

181. Palczewski, K., I. Sokal, and W. Baehr, Guanylate cyclase–activating proteins: structure, function, and diversity. Biochem Biophys Res Commun, 2004. 322(4): p. 1123–30.

182. Park, P.S., S. Filipek, J.W. Wells, and K. Palczewski, Oligomerization of G protein–coupled receptors: past, present, and future. Biochemistry, 2004. 43(50): p. 15643–56.

183. Subramanian, L., J.W. Crabb, J. Cox, I. Durussel, T.M. Walker, P.R. van Ginkel, S. Bhattacharya, J.M. Dellaria, K. Palczewski, and A.S. Polans, Ca2+ binding to EF hands 1 and 3 is essential for the interaction of apoptosis–linked gene–2 with Alix/AIP1 in ocular melanoma. Biochemistry, 2004. 43(35): p. 11175–86.

184. Suda, K., S. Filipek, K. Palczewski, A. Engel, and D. Fotiadis, The supramolecular structure of the GPCR rhodopsin in solution and native disc membranes. Mol Membr Biol, 2004. 21(6): p. 435–46.

185. Tu, D.C., M.L. Batten, K. Palczewski, and R.N. Van Gelder, Nonvisual photoreception in the chick iris. Science, 2004. 306(5693): p. 129–31.

186. Zhu, L., G.F. Jang, B. Jastrzebska, S. Filipek, S.E. Pearce–Kelling, G.D. Aguirre, R.E. Stenkamp, G.M. Acland, and K. Palczewski, A naturally occurring mutation of the opsin gene (T4R) in dogs affects glycosylation and stability of the G protein–coupled receptor. J Biol Chem, 2004. 279(51): p. 53828–39.

13

187. Acland, G.M., G.D. Aguirre, J. Bennett, T.S. Aleman, A.V. Cideciyan, J. Bennicelli, N.S. Dejneka, S.E. Pearce–Kelling, A.M. Maguire, K. Palczewski, W.W. Hauswirth, and S.G. Jacobson, Long–term restoration of rod and cone vision by single dose rAAV–mediated gene transfer to the retina in a canine model of childhood blindness. Mol Ther, 2005. 12(6): p. 1072–82.

188. Bartl, F.J., O. Fritze, E. Ritter, R. Herrmann, V. Kuksa, K. Palczewski, K.P. Hofmann, and O.P. Ernst, Partial agonism in a G Protein–coupled receptor: role of the retinal ring structure in rhodopsin activation. J Biol Chem, 2005. 280(40): p. 34259–67.

189. Batten, M.L., Y. Imanishi, D.C. Tu, T. Doan, L. Zhu, J. Pang, L. Glushakova, A.R. Moise, W. Baehr, R.N. Van Gelder, W.W. Hauswirth, F. Rieke, and K. Palczewski, Pharmacological and rAAV gene therapy rescue of visual functions in a blind mouse model of Leber congenital amaurosis. PLoS Med, 2005. 2(11): p. e333.

190. Golczak, M., Y. Imanishi, V. Kuksa, T. Maeda, R. Kubota, and K. Palczewski, Lecithin:retinol acyltransferase is responsible for amidation of retinylamine, a potent inhibitor of the retinoid cycle. J Biol Chem, 2005. 280(51): p. 42263–73.

191. Golczak, M., V. Kuksa, T. Maeda, A.R. Moise, and K. Palczewski, Positively charged retinoids are potent and selective inhibitors of the trans–cis isomerization in the retinoid (visual) cycle. Proc Natl Acad Sci U S A, 2005. 102(23): p. 8162–7.

192. Jacobson, S.G., T.S. Aleman, A.V. Cideciyan, A. Sumaroka, S.B. Schwartz, E.A. Windsor, E.I. Traboulsi, E. Heon, S.J. Pittler, A.H. Milam, A.M. Maguire, K. Palczewski, E.M. Stone, and J. Bennett, Identifying photoreceptors in blind eyes caused by RPE65 mutations: Prerequisite for human gene therapy success. Proc Natl Acad Sci U S A, 2005. 102(17): p. 6177–82.

193. Kim, T.S., A. Maeda, T. Maeda, C. Heinlein, N. Kedishvili, K. Palczewski, and P.S. Nelson, Delayed dark adaptation in 11–cis–retinol dehydrogenase–deficient mice: a role of RDH11 in visual processes in vivo. J Biol Chem, 2005. 280(10): p. 8694–704.

194. Maeda, A., J.W. Crabb, and K. Palczewski, Microsomal glutathione S–transferase 1 in the retinal pigment epithelium: protection against oxidative stress and a potential role in aging. Biochemistry, 2005. 44(2): p. 480–9.

195. Maeda, A., T. Maeda, Y. Imanishi, V. Kuksa, A. Alekseev, J.D. Bronson, H. Zhang, L. Zhu, W. Sun, D.A. Saperstein, F. Rieke, W. Baehr, and K. Palczewski, Role of photoreceptor–specific retinol dehydrogenase in the retinoid cycle in vivo. J Biol Chem, 2005. 280(19): p. 18822–32.

196. Maeda, T., J. Lem, K. Palczewski, and F. Haeseleer, A critical role of CaBP4 in the cone synapse. Invest Ophthalmol Vis Sci, 2005. 46(11): p. 4320–7.

197. Moise, A.R., V. Kuksa, W.S. Blaner, W. Baehr, and K. Palczewski, Metabolism and transactivation activity of 13,14–dihydroretinoic acid. J Biol Chem, 2005. 280(30): p. 27815–25.

198. Moise, A.R., J. von Lintig, and K. Palczewski, Related enzymes solve evolutionarily recurrent problems in the metabolism of carotenoids. Trends Plant Sci, 2005. 10(4): p. 178–86.

199. O'Byrne, S.M., N. Wongsiriroj, J. Libien, S. Vogel, I.J. Goldberg, W. Baehr, K. Palczewski, and W.S. Blaner, Retinoid absorption and storage is impaired in mice lacking lecithin:retinol acyltransferase (LRAT). J Biol Chem, 2005. 280(42): p. 35647–57.200. Park, P.S. and K. Palczewski, Imaging G protein–coupled receptor islands. Nat Chem Biol, 2005. 1(4): p. 184–5.

201. Park, P.S. and K. Palczewski, Diversifying the repertoire of G protein–coupled receptors through oligomerization. Proc Natl Acad Sci U S A, 2005. 102(25): p. 8793–4.

14

202. Sokal, I., W.J. Dupps, M.A. Grassi, J. Brown, Jr., L.M. Affatigato, N. Roychowdhury, L. Yang, S. Filipek, K. Palczewski, E.M. Stone, and W. Baehr, A novel GCAP1 missense mutation (L151F) in a large family with autosomal dominant cone–rod dystrophy (adCORD). Invest Ophthalmol Vis Sci, 2005. 46(4): p. 1124–32.

203. Stenkamp, R.E., D.C. Teller, and K. Palczewski, Rhodopsin: a structural primer for G–protein coupled receptors. Arch Pharm (Weinheim), 2005. 338(5–6): p. 209–16.

204. Wingard, J.N., J. Chan, I. Bosanac, F. Haeseleer, K. Palczewski, M. Ikura, and J.B. Ames, Structural analysis of Mg2+ and Ca2+ binding to CaBP1, a neuron–specific regulator of calcium channels. J Biol Chem, 2005. 280(45): p. 37461–70.

205. Zhang, L., D. Salom, J. He, A. Okun, J. Ballesteros, K. Palczewski, and N. Li, Expression of functional G protein–coupled receptors in photoreceptors of transgenic Xenopus laevis. Biochemistry, 2005. 44(44): p. 14509–18.

206. Dominguez, M., R. Alvarez, M. Perez, K. Palczewski, and A.R. de Lera, The role of the 11–cis–retinal ring methyl substituents in visual pigment formation. Chembiochem, 2006. 7(11): p. 1815–25.

207. Fotiadis, D., B. Jastrzebska, A. Philippsen, D.J. Muller, K. Palczewski, and A. Engel, Structure of the rhodopsin dimer: a working model for G–protein–coupled receptors. Curr Opin Struct Biol, 2006. 16(2): p. 252–9.

208. Haire, S.E., J. Pang, S.L. Boye, I. Sokal, C.M. Craft, K. Palczewski, W.W. Hauswirth, and S.L. Semple–Rowland, Light–driven cone arrestin translocation in cones of postnatal guanylate cyclase–1 knockout mouse retina treated with AAV–GC1. Invest Ophthalmol Vis Sci, 2006. 47(9): p. 3745–53.

209. Jastrzebska, B., D. Fotiadis, G.F. Jang, R.E. Stenkamp, A. Engel, and K. Palczewski, Functional and structural characterization of rhodopsin oligomers. J Biol Chem, 2006. 281(17): p. 11917–22.

210. Maeda, A., T. Maeda, M. Golczak, Y. Imanishi, P. Leahy, R. Kubota, and K. Palczewski, Effects of potent inhibitors of the retinoid cycle on visual function and photoreceptor protection from light damage in mice. Mol Pharmacol, 2006. 70(4): p. 1220–9.

211. Maeda, A., T. Maeda, Y. Imanishi, M. Golczak, A.R. Moise, and K. Palczewski, Aberrant metabolites in mouse models of congenital blinding diseases: formation and storage of retinyl esters. Biochemistry, 2006. 45(13): p. 4210–9.

212. Maeda, A., T. Maeda, Y. Imanishi, W. Sun, B. Jastrzebska, D.A. Hatala, H.J. Winkens, K.P. Hofmann, J.J. Janssen, W. Baehr, C.A. Driessen, and K. Palczewski, Retinol dehydrogenase (RDH12) protects photoreceptors from light–induced degeneration in mice. J Biol Chem, 2006. 281(49): p. 37697–704.

213. Maeda, A., T. Maeda, and K. Palczewski, Improvement in rod and cone function in mouse model of Fundus albipunctatus after pharmacologic treatment with 9–cis–retinal. Invest Ophthalmol Vis Sci, 2006. 47(10): p. 4540–6.

214. Mansoor, S.E., K. Palczewski, and D.L. Farrens, Rhodopsin self–associates in asolectin liposomes. Proc Natl Acad Sci U S A, 2006. 103(9): p. 3060–5.

215. Modzelewska, A., S. Filipek, K. Palczewski, and P.S. Park, Arrestin interaction with rhodopsin: conceptual models. Cell Biochem Biophys, 2006. 46(1): p. 1–15.

216. Palczewski, K., G protein–coupled receptor rhodopsin. Annu Rev Biochem, 2006. 75: p. 743–67.

15

217. Palczewski, K., K.P. Hofmann, and W. Baehr, Rhodopsin––advances and perspectives. Vision Res, 2006. 46(27): p. 4425–6.

218. Salom, D., I. Le Trong, E. Pohl, J.A. Ballesteros, R.E. Stenkamp, K. Palczewski, and D.T. Lodowski, Improvements in G protein–coupled receptor purification yield light stable rhodopsin crystals. J Struct Biol, 2006. 156(3): p. 497–504.

219. Salom, D., D.T. Lodowski, R.E. Stenkamp, I. Le Trong, M. Golczak, B. Jastrzebska, T. Harris, J.A. Ballesteros, and K. Palczewski, Crystal structure of a photoactivated deprotonated intermediate of rhodopsin. Proc Natl Acad Sci U S A, 2006. 103(44): p. 16123–8.

220. Stephen, R., K. Palczewski, and M.C. Sousa, The crystal structure of GCAP3 suggests molecular mechanism of GCAP–linked cone dystrophies. J Mol Biol, 2006. 359(2): p. 266–75.

221. Tanuj Sapra, K., P.S. Park, S. Filipek, A. Engel, D.J. Muller, and K. Palczewski, Detecting molecular interactions that stabilize native bovine rhodopsin. J Mol Biol, 2006. 358(1): p. 255–69.

222. Tu, D.C., L.A. Owens, L. Anderson, M. Golczak, S.E. Doyle, M. McCall, M. Menaker, K. Palczewski, and R.N. Van Gelder, Inner retinal photoreception independent of the visual retinoid cycle. Proc Natl Acad Sci U S A, 2006. 103(27): p. 10426–31.

223. Williams, M.L., J.E. Coleman, S.E. Haire, T.S. Aleman, A.V. Cideciyan, I. Sokal, K. Palczewski, S.G. Jacobson, and S.L. Semple–Rowland, Lentiviral expression of retinal guanylate cyclase–1 (RetGC1) restores vision in an avian model of childhood blindness. PLoS Med, 2006. 3(6): p. e201.

224. Zhu, L., Y. Imanishi, S. Filipek, A. Alekseev, B. Jastrzebska, W. Sun, D.A. Saperstein, and K. Palczewski, Autosomal recessive retinitis pigmentosa and E150K mutation in the opsin gene. J Biol Chem, 2006. 281(31): p. 22289–98.

225. Baehr, W., S. Karan, T. Maeda, D.G. Luo, S. Li, J.D. Bronson, C.B. Watt, K.W. Yau, J.M. Frederick, and K. Palczewski, The function of guanylate cyclase 1 and guanylate cyclase 2 in rod and cone photoreceptors. J Biol Chem, 2007. 282(12): p. 8837–47.

226. Baehr, W. and K. Palczewski, Guanylate cyclase–activating proteins and retina disease. Subcell Biochem, 2007. 45: p. 71–91.

227. Isken, A., J. Holzschuh, J.M. Lampert, L. Fischer, V. Oberhauser, K. Palczewski, and J. von Lintig, Sequestration of retinyl esters is essential for retinoid signaling in the zebrafish embryo. J Biol Chem, 2007. 282(2): p. 1144–51.

228. Jacobson, S.G., T.S. Aleman, A.V. Cideciyan, E. Heon, M. Golczak, W.A. Beltran, A. Sumaroka, S.B. Schwartz, A.J. Roman, E.A. Windsor, J.M. Wilson, G.D. Aguirre, E.M. Stone, and K. Palczewski, Human cone photoreceptor dependence on RPE65 isomerase. Proc Natl Acad Sci U S A, 2007. 104(38): p. 15123–8.

229. Kiser, P.D., D.T. Lodowski, and K. Palczewski, Purification, crystallization and structure determination of native GroEL from Escherichia coli lacking bound potassium ions. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2007. 63(Pt 6): p. 457–61.

230. Li, N., D. Salom, L. Zhang, T. Harris, J.A. Ballesteros, M. Golczak, B. Jastrzebska, K. Palczewski, C. Kurahara, T. Juan, S. Jordan, and J.A. Salon, Heterologous expression of the adenosine A1 receptor in transgenic mouse retina. Biochemistry, 2007. 46(28): p. 8350–9.

231. Lodowski, D.T., D. Salom, I. Le Trong, D.C. Teller, J.A. Ballesteros, K. Palczewski, and R.E. Stenkamp, Reprint of "Crystal packing analysis of Rhodopsin crystals" [J. Struct. Biol. 158 (2007) 455–462]. J Struct Biol, 2007. 159(2): p. 253–60.

16

232. Lodowski, D.T., D. Salom, I. Le Trong, D.C. Teller, J.A. Ballesteros, K. Palczewski, and R.E. Stenkamp, Crystal packing analysis of Rhodopsin crystals. J Struct Biol, 2007. 158(3): p. 455–62.

233. Maeda, A., T. Maeda, W. Sun, H. Zhang, W. Baehr, and K. Palczewski, Redundant and unique roles of retinol dehydrogenases in the mouse retina. Proc Natl Acad Sci U S A, 2007. 104(49): p. 19565–70.

234. Moise, A.R., M. Golczak, Y. Imanishi, and K. Palczewski, Topology and membrane association of lecithin: retinol acyltransferase. J Biol Chem, 2007. 282(3): p. 2081–90.

235. Moise, A.R., A. Isken, M. Dominguez, A.R. de Lera, J. von Lintig, and K. Palczewski, Specificity of zebrafish retinol saturase: formation of all–trans–13,14–dihydroretinol and all–trans–7,8– dihydroretinol. Biochemistry, 2007. 46(7): p. 1811–20.

236. Moise, A.R., N. Noy, K. Palczewski, and W.S. Blaner, Delivery of retinoid–based therapies to target tissues. Biochemistry, 2007. 46(15): p. 4449–58.

237. Nickell, S., P.S. Park, W. Baumeister, and K. Palczewski, Three–dimensional architecture of murine rod outer segments determined by cryoelectron tomography. J Cell Biol, 2007. 177(5): p. 917–25.

238. Park, P.S., K.T. Sapra, M. Kolinski, S. Filipek, K. Palczewski, and D.J. Muller, Stabilizing effect of Zn2+ in native bovine rhodopsin. J Biol Chem, 2007. 282(15): p. 11377–85.

239. Pin, J.P., R. Neubig, M. Bouvier, L. Devi, M. Filizola, J.A. Javitch, M.J. Lohse, G. Milligan, K. Palczewski, M. Parmentier, and M. Spedding, International Union of Basic and Clinical Pharmacology. LXVII. Recommendations for the recognition and nomenclature of G protein–coupled receptor heteromultimers. Pharmacol Rev, 2007. 59(1): p. 5–13.

240. Ridge, K.D. and K. Palczewski, Visual rhodopsin sees the light: structure and mechanism of G protein signaling. J Biol Chem, 2007. 282(13): p. 9297–301.

241. Schonthaler, H.B., J.M. Lampert, A. Isken, O. Rinner, A. Mader, M. Gesemann, V. Oberhauser, M. Golczak, O. Biehlmaier, K. Palczewski, S.C. Neuhauss, and J. von Lintig, Evidence for RPE65–independent vision in the cone–dominated zebrafish retina. Eur J Neurosci, 2007. 26(7): p. 1940–9.

242. Skrabanek, L., M. Murcia, M. Bouvier, L. Devi, S.R. George, M.J. Lohse, G. Milligan, R. Neubig, K. Palczewski, M. Parmentier, J.P. Pin, G. Vriend, J.A. Javitch, F. Campagne, and M. Filizola, Requirements and ontology for a G protein–coupled receptor oligomerization knowledge base. BMC Bioinformatics, 2007. 8: p. 177.

243. Stephen, R., G. Bereta, M. Golczak, K. Palczewski, and M.C. Sousa, Stabilizing function for myristoyl group revealed by the crystal structure of a neuronal calcium sensor, guanylate cyclase–activating protein 1. Structure, 2007. 15(11): p. 1392–402.

244. Sun, W., C. Gerth, A. Maeda, D.T. Lodowski, L. Van Der Kraak, D.A. Saperstein, E. Heon, and K. Palczewski, Novel RDH12 mutations associated with Leber congenital amaurosis and cone–rod dystrophy: biochemical and clinical evaluations. Vision Res, 2007. 47(15): p. 2055–66.

245. Travis, G.H., M. Golczak, A.R. Moise, and K. Palczewski, Diseases caused by defects in the visual cycle: retinoids as potential therapeutic agents. Annu Rev Pharmacol Toxicol, 2007. 47: p. 469–512.

246. Bereta, G., P.D. Kiser, M. Golczak, W. Sun, E. Heon, D.A. Saperstein, and K. Palczewski, Impact of retinal disease–associated RPE65 mutations on retinoid isomerization. Biochemistry, 2008. 47(37): p. 9856–65.

17

247. Goc, A., T.E. Angel, B. Jastrzebska, B. Wang, P.L. Wintrode, and K. Palczewski, Different properties of the native and reconstituted heterotrimeric G protein transducin. Biochemistry, 2008. 47(47): p. 12409–19.

248. Golczak, M., A. Maeda, G. Bereta, T. Maeda, P.D. Kiser, S. Hunzelmann, J. von Lintig, W.S. Blaner, and K. Palczewski, Metabolic basis of visual cycle inhibition by retinoid and nonretinoid compounds in the vertebrate retina. J Biol Chem, 2008. 283(15): p. 9543–54.

249. Imanishi, Y., W. Sun, T. Maeda, A. Maeda, and K. Palczewski, Retinyl ester homeostasis in the adipose differentiation–related protein–deficient retina. J Biol Chem, 2008. 283(36): p. 25091–102.

250. Isken, A., M. Golczak, V. Oberhauser, S. Hunzelmann, W. Driever, Y. Imanishi, K. Palczewski, and J. von Lintig, RBP4 disrupts vitamin A uptake homeostasis in a STRA6–deficient animal model for Matthew–Wood syndrome. Cell Metab, 2008. 7(3): p. 258–68.

251. Jiang, L., D. Wheaton, G. Bereta, K. Zhang, K. Palczewski, D.G. Birch, and W. Baehr, A novel GCAP1(N104K) mutation in EF–hand 3 (EF3) linked to autosomal dominant cone dystrophy. Vision Res, 2008. 48(23–24): p. 2425–32.

252. Kim, Y.K., L. Wassef, L. Hamberger, R. Piantedosi, K. Palczewski, W.S. Blaner, and L. Quadro, Retinyl ester formation by lecithin: retinol acyltransferase is a key regulator of retinoid homeostasis in mouse embryogenesis. J Biol Chem, 2008. 283(9): p. 5611–21.

253. Maeda, A., T. Maeda, M. Golczak, and K. Palczewski, Retinopathy in mice induced by disrupted all–trans–retinal clearance. J Biol Chem, 2008. 283(39): p. 26684–93.

254. Moise, A.R., M. Dominguez, S. Alvarez, R. Alvarez, M. Schupp, A.G. Cristancho, P.D. Kiser, A.R. de Lera, M.A. Lazar, and K. Palczewski, Stereospecificity of retinol saturase: absolute configuration, synthesis, and biological evaluation of dihydroretinoids. J Am Chem Soc, 2008. 130(4): p. 1154–5.

255. Muller, D.J., N. Wu, and K. Palczewski, Vertebrate membrane proteins: structure, function, and insights from biophysical approaches. Pharmacol Rev, 2008. 60(1): p. 43–78.

256. Park, P.S., D.T. Lodowski, and K. Palczewski, Activation of G protein–coupled receptors: beyond two–state models and tertiary conformational changes. Annu Rev Pharmacol Toxicol, 2008. 48: p. 107–41.

257. Salom, D., N. Wu, W. Sun, Z. Dong, K. Palczewski, S. Jordan, and J.A. Salon, Heterologous expression and purification of the serotonin type 4 receptor from transgenic mouse retina. Biochemistry, 2008. 47(50): p. 13296–307.

258. Sapra, K.T., P.S. Park, K. Palczewski, and D.J. Muller, Mechanical properties of bovine rhodopsin and bacteriorhodopsin: possible roles in folding and function. Langmuir, 2008. 24(4): p. 1330–7.

259. Singh, P., B. Wang, T. Maeda, K. Palczewski, and J.J. Tesmer, Structures of rhodopsin kinase in different ligand states reveal key elements involved in G protein–coupled receptor kinase activation. J Biol Chem, 2008. 283(20): p. 14053–62.

260. Stephen, R., S. Filipek, K. Palczewski, and M.C. Sousa, Ca2+ –dependent regulation of phototransduction. Photochem Photobiol, 2008. 84(4): p. 903–10.

261. Whorton, M.R., B. Jastrzebska, P.S. Park, D. Fotiadis, A. Engel, K. Palczewski, and R.K. Sunahara, Efficient coupling of transducin to monomeric rhodopsin in a phospholipid bilayer. J Biol Chem, 2008. 283(7): p. 4387–94.

18

262. Wongsiriroj, N., R. Piantedosi, K. Palczewski, I.J. Goldberg, T.P. Johnston, E. Li, and W.S. Blaner, The molecular basis of retinoid absorption: a genetic dissection. J Biol Chem, 2008. 283(20): p. 13510–9.

263. Zhang, H., J. Fan, S. Li, S. Karan, B. Rohrer, K. Palczewski, J.M. Frederick, R.K. Crouch, and W. Baehr, Trafficking of membrane–associated proteins to cone photoreceptor outer segments requires the chromophore 11–cis–retinal. J Neurosci, 2008. 28(15): p. 4008–14.

264. Angel, T.E., M.R. Chance, and K. Palczewski, Conserved waters mediate structural and functional activation of family A (rhodopsin–like) G protein–coupled receptors. Proc Natl Acad Sci U S A, 2009. 106(21): p. 8555–60.

265. Angel, T.E., S. Gupta, B. Jastrzebska, K. Palczewski, and M.R. Chance, Structural waters define a functional channel mediating activation of the GPCR, rhodopsin. Proc Natl Acad Sci U S A, 2009. 106(34): p. 14367–72.

266. Baehr, W. and K. Palczewski, Focus on molecules: guanylate cyclase–activating proteins (GCAPs). Exp Eye Res, 2009. 89(1): p. 2–3.

267. Cideciyan, A.V., M. Swider, T.S. Aleman, Y. Tsybovsky, S.B. Schwartz, E.A. Windsor, A.J. Roman, A. Sumaroka, J.D. Steinberg, S.G. Jacobson, E.M. Stone, and K. Palczewski, ABCA4 disease progression and a proposed strategy for gene therapy. Hum Mol Genet, 2009. 18(5): p. 931–41.

268. Geng, R., S.F. Geller, T. Hayashi, C.A. Ray, T.A. Reh, O. Bermingham–McDonogh, S.M. Jones, C.G. Wright, S. Melki, Y. Imanishi, K. Palczewski, K.N. Alagramam, and J.G. Flannery, Usher syndrome IIIA gene clarin–1 is essential for hair cell function and associated neural activation. Hum Mol Genet, 2009. 18(15): p. 2748–60.

269. Jastrzebska, B., A. Goc, M. Golczak, and K. Palczewski, Phospholipids are needed for the proper formation, stability, and function of the photoactivated rhodopsin–transducin complex. Biochemistry, 2009. 48(23): p. 5159–70.

270. Jastrzebska, B., M. Golczak, D. Fotiadis, A. Engel, and K. Palczewski, Isolation and functional characterization of a stable complex between photoactivated rhodopsin and the G protein, transducin. FASEB J, 2009. 23(2): p. 371–81.

271. Kiser, P.D., M. Golczak, D.T. Lodowski, M.R. Chance, and K. Palczewski, Crystal structure of native RPE65, the retinoid isomerase of the visual cycle. Proc Natl Acad Sci U S A, 2009. 106(41): p. 17325–30.

272. Kiser, P.D., G.H. Lorimer, and K. Palczewski, Use of thallium to identify monovalent cation binding sites in GroEL. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2009. 65(Pt 10): p. 967–71.

273. Li, C., J. Chan, F. Haeseleer, K. Mikoshiba, K. Palczewski, M. Ikura, and J.B. Ames, Structural insights into Ca2+–dependent regulation of inositol 1,4,5–trisphosphate receptors by CaBP1. J Biol Chem, 2009. 284(4): p. 2472–81.

274. Lodowski, D.T., T.E. Angel, and K. Palczewski, Comparative analysis of GPCR crystal structures. Photochem Photobiol, 2009. 85(2): p. 425–30.

275. Lodowski, D.T. and K. Palczewski, Chemokine receptors and other G protein–coupled receptors. Curr Opin HIV AIDS, 2009. 4(2): p. 88–95.

276. Maeda, A., M. Golczak, T. Maeda, and K. Palczewski, Limited roles of Rdh8, Rdh12, and Abca4 in all–trans–retinal clearance in mouse retina. Invest Ophthalmol Vis Sci, 2009. 50(11): p. 5435–43.

19

277. Maeda, A., T. Maeda, M. Golczak, S. Chou, A. Desai, C.L. Hoppel, S. Matsuyama, and K. Palczewski, Involvement of all–trans–retinal in acute light–induced retinopathy of mice. J Biol Chem, 2009. 284(22): p. 15173–83.

278. Maeda, T., A.V. Cideciyan, A. Maeda, M. Golczak, T.S. Aleman, S.G. Jacobson, and K. Palczewski, Loss of cone photoreceptors caused by chromophore depletion is partially prevented by the artificial chromophore pro–drug, 9–cis–retinyl acetate. Hum Mol Genet, 2009. 18(12): p. 2277–87.

279. Maeda, T., A. Maeda, G. Casadesus, K. Palczewski, and P. Margaron, Evaluation of 9–cis–retinyl acetate therapy in Rpe65–/– mice. Invest Ophthalmol Vis Sci, 2009. 50(9): p. 4368–78.

280. Maeda, T., A. Maeda, P. Leahy, D.A. Saperstein, and K. Palczewski, Effects of long–term administration of 9–cis–retinyl acetate on visual function in mice. Invest Ophthalmol Vis Sci, 2009. 50(1): p. 322–33.

281. Maeda, T., A. Maeda, M. Matosky, K. Okano, S. Roos, J. Tang, and K. Palczewski, Evaluation of potential therapies for a mouse model of human age–related macular degeneration caused by delayed all–trans–retinal clearance. Invest Ophthalmol Vis Sci, 2009. 50(10): p. 4917–25.

282. Moise, A.R., S. Alvarez, M. Dominguez, R. Alvarez, M. Golczak, G.P. Lobo, J. von Lintig, A.R. de Lera, and K. Palczewski, Activation of retinoic acid receptors by dihydroretinoids. Mol Pharmacol, 2009. 76(6): p. 1228–37.

283. Mustafi, D., A.H. Engel, and K. Palczewski, Structure of cone photoreceptors. Prog Retin Eye Res, 2009. 28(4): p. 289–302.

284. Mustafi, D. and K. Palczewski, Topology of class A G protein–coupled receptors: insights gained from crystal structures of rhodopsins, adrenergic and adenosine receptors. Mol Pharmacol, 2009. 75(1): p. 1–12.

285. Park, P.S., K.T. Sapra, B. Jastrzebska, T. Maeda, A. Maeda, W. Pulawski, M. Kono, J. Lem, R.K. Crouch, S. Filipek, D.J. Muller, and K. Palczewski, Modulation of molecular interactions and function by rhodopsin palmitylation. Biochemistry, 2009. 48(20): p. 4294–304.

286. Tian, G., Y. Zhou, D. Hajkova, M. Miyagi, A. Dinculescu, W.W. Hauswirth, K. Palczewski, R. Geng, K.N. Alagramam, J. Isosomppi, E.M. Sankila, J.G. Flannery, and Y. Imanishi, Clarin–1, encoded by the Usher Syndrome III causative gene, forms a membranous microdomain: possible role of clarin–1 in organizing the actin cytoskeleton. J Biol Chem, 2009. 284(28): p. 18980–93.

287. Bereta, G., B. Wang, P.D. Kiser, W. Baehr, G.F. Jang, and K. Palczewski, A functional kinase homology domain is essential for the activity of photoreceptor guanylate cyclase 1. J Biol Chem, 2010. 285(3): p. 1899–908.

288. Cao, P., Y. Yuan, E.A. Pehek, A.R. Moise, Y. Huang, K. Palczewski, and Z. Feng, Alpha–synuclein disrupted dopamine homeostasis leads to dopaminergic neuron degeneration in Caenorhabditis elegans. PLoS One, 2010. 5(2): p. e9312.

289. Goc, A., M. Chami, D.T. Lodowski, P. Bosshart, V. Moiseenkova–Bell, W. Baehr, A. Engel, and K. Palczewski, Structural characterization of the rod cGMP phosphodiesterase 6. J Mol Biol, 2010. 401(3): p. 363–73.

290. Golczak, M., G. Bereta, A. Maeda, and K. Palczewski, Molecular biology and analytical chemistry methods used to probe the retinoid cycle. Methods Mol Biol, 2010. 652: p. 229–45.

291. Golczak, M., P.D. Kiser, D.T. Lodowski, A. Maeda, and K. Palczewski, Importance of membrane structural integrity for RPE65 retinoid isomerization activity. J Biol Chem, 2010. 285(13): p. 9667–82.

20

292. Golczak, M. and K. Palczewski, An acyl–covalent enzyme intermediate of lecithin:retinol acyltransferase. J Biol Chem, 2010. 285(38): p. 29217–22.

293. Huang, J., Z. Xu, D. Wang, C.M. Ogata, K. Palczewski, X. Lee, and N.M. Young, Characterization of the secondary binding sites of Maclura pomifera agglutinin by glycan array and crystallographic analyses. Glycobiology, 2010. 20(12): p. 1643–53.

294. Hunter, J.J., B. Masella, A. Dubra, R. Sharma, L. Yin, W.H. Merigan, G. Palczewska, K. Palczewski, and D.R. Williams, Images of photoreceptors in living primate eyes using adaptive optics two–photon ophthalmoscopy. Biomed Opt Express, 2010. 2(1): p. 139–48.

295. Imanishi, Y. and K. Palczewski, Visualization of retinoid storage and trafficking by two–photon microscopy. Methods Mol Biol, 2010. 652: p. 247–61.

296. Jastrzebska, B., Y. Tsybovsky, and K. Palczewski, Complexes between photoactivated rhodopsin and transducin: progress and questions. Biochem J, 2010. 428(1): p. 1–10.

297. Kevany, B.M. and K. Palczewski, Phagocytosis of retinal rod and cone photoreceptors. Physiology (Bethesda), 2010. 25(1): p. 8–15.

298. Khelashvili, G., K. Dorff, J. Shan, M. Camacho–Artacho, L. Skrabanek, B. Vroling, M. Bouvier, L.A. Devi, S.R. George, J.A. Javitch, M.J. Lohse, G. Milligan, R.R. Neubig, K. Palczewski, M. Parmentier, J.P. Pin, G. Vriend, F. Campagne, and M. Filizola, GPCR–OKB: the G Protein Coupled Receptor Oligomer Knowledge Base. Bioinformatics, 2010. 26(14): p. 1804–5.

299. Kiser, P.D. and K. Palczewski, Membrane–binding and enzymatic properties of RPE65. Prog Retin Eye Res, 2010. 29(5): p. 428–42.

300. Lobo, G.P., J. Amengual, H.N. Li, M. Golczak, M.L. Bonet, K. Palczewski, and J. von Lintig, Beta,beta–carotene decreases peroxisome proliferator receptor gamma activity and reduces lipid storage capacity of adipocytes in a beta,beta–carotene oxygenase 1–dependent manner. J Biol Chem, 2010. 285(36): p. 27891–9.

301. Lobo, G.P., S. Hessel, A. Eichinger, N. Noy, A.R. Moise, A. Wyss, K. Palczewski, and J. von Lintig, ISX is a retinoic acid–sensitive gatekeeper that controls intestinal beta,beta–carotene absorption and vitamin A production. FASEB J, 2010. 24(6): p. 1656–66.

302. Lodowski, D.T., K. Palczewski, and M. Miyagi, Conformational changes in the g protein–coupled receptor rhodopsin revealed by histidine hydrogen–deuterium exchange. Biochemistry, 2010. 49(44): p. 9425–7.

303. Maeda, A., K. Okano, P.S. Park, J. Lem, R.K. Crouch, T. Maeda, and K. Palczewski, Palmitoylation stabilizes unliganded rod opsin. Proc Natl Acad Sci U S A, 2010. 107(18): p. 8428–33.

304. Moise, A.R., G.P. Lobo, B. Erokwu, D.L. Wilson, D. Peck, S. Alvarez, M. Dominguez, R. Alvarez, C.A. Flask, A.R. de Lera, J. von Lintig, and K. Palczewski, Increased adiposity in the retinol saturase–knockout mouse. FASEB J, 2010. 24(4): p. 1261–70.

305. O'Byrne, S.M., Y. Kako, R.J. Deckelbaum, I.H. Hansen, K. Palczewski, I.J. Goldberg, and W.S. Blaner, Multiple pathways ensure retinoid delivery to milk: studies in genetically modified mice. Am J Physiol Endocrinol Metab, 2010. 298(4): p. E862–70.

306. Orban, T., G. Bereta, M. Miyagi, B. Wang, M.R. Chance, M.C. Sousa, and K. Palczewski, Conformational changes in guanylate cyclase–activating protein 1 induced by Ca2+ and N–terminal fatty acid acylation. Structure, 2010. 18(1): p. 116–26.

307. Orban, T., S. Gupta, K. Palczewski, and M.R. Chance, Visualizing water molecules in transmembrane proteins using radiolytic labeling methods. Biochemistry, 2010. 49(5): p. 827–34.

21

308. Palczewska, G., T. Maeda, Y. Imanishi, W. Sun, Y. Chen, D.R. Williams, D.W. Piston, A. Maeda, and K. Palczewski, Noninvasive multiphoton fluorescence microscopy resolves retinol and retinal condensation products in mouse eyes. Nat Med, 2010. 16(12): p. 1444–9.

309. Palczewski, K., Blind dogs that can see: pharmacological treatment of Leber congenital amaurosis caused by a defective visual cycle. Arch Ophthalmol, 2010. 128(11): p. 1483–5.

310. Palczewski, K., Oligomeric forms of G protein–coupled receptors (GPCRs). Trends Biochem Sci, 2010. 35(11): p. 595–600.

311. Palczewski, K., Retinoids for treatment of retinal diseases. Trends Pharmacol Sci, 2010. 31(6): p. 284–95.

312. Pulagam, L.P. and K. Palczewski, Electrostatic compensation restores trafficking of the autosomal recessive retinitis pigmentosa E150K opsin mutant to the plasma membrane. J Biol Chem, 2010. 285(38): p. 29446–56.

313. Tsybovsky, Y., R.S. Molday, and K. Palczewski, The ATP–binding cassette transporter ABCA4: structural and functional properties and role in retinal disease. Adv Exp Med Biol, 2010. 703: p. 105–25.

314. von Lintig, J., P.D. Kiser, M. Golczak, and K. Palczewski, The biochemical and structural basis for trans–to–cis isomerization of retinoids in the chemistry of vision. Trends Biochem Sci, 2010. 35(7): p. 400–10.

315. Amengual, J., G.P. Lobo, M. Golczak, H.N. Li, T. Klimova, C.L. Hoppel, A. Wyss, K. Palczewski, and J. von Lintig, A mitochondrial enzyme degrades carotenoids and protects against oxidative stress. FASEB J, 2011. 25(3): p. 948–59.

316. Baker, B.Y. and K. Palczewski, Detergents stabilize the conformation of phosphodiesterase 6. Biochemistry, 2011. 50(44): p. 9520–31.

317. Bereta, G. and K. Palczewski, Heterogeneous N–terminal acylation of retinal proteins results from the retina's unusual lipid metabolism. Biochemistry, 2011. 50(18): p. 3764–76.

318. Huang, C.C., T. Orban, B. Jastrzebska, K. Palczewski, and J.J. Tesmer, Activation of G protein–coupled receptor kinase 1 involves interactions between its N–terminal region and its kinase domain. Biochemistry, 2011. 50(11): p. 1940–9.

319. Jastrzebska, B., A. Debinski, S. Filipek, and K. Palczewski, Role of membrane integrity on G protein–coupled receptors: Rhodopsin stability and function. Prog Lipid Res, 2011. 50(3): p. 267–77.

320. Jastrzebska, B., K. Palczewski, and M. Golczak, Role of bulk water in hydrolysis of the rhodopsin chromophore. J Biol Chem, 2011. 286(21): p. 18930–7.

321. Jastrzebska, B., P. Ringler, D.T. Lodowski, V. Moiseenkova–Bell, M. Golczak, S.A. Muller, K. Palczewski, and A. Engel, Rhodopsin–transducin heteropentamer: three–dimensional structure and biochemical characterization. J Struct Biol, 2011. 176(3): p. 387–94.

322. Li, H., K. Palczewski, W. Baehr, and M. Clagett–Dame, Vitamin A deficiency results in meiotic failure and accumulation of undifferentiated spermatogonia in prepubertal mouse testis. Biol Reprod, 2011. 84(2): p. 336–41.

323. Maeda, T., L. Perusek, J. Amengual, D. Babino, K. Palczewski, and J. von Lintig, Dietary 9–cis–beta,beta–carotene fails to rescue vision in mouse models of leber congenital amaurosis. Mol Pharmacol, 2011. 80(5): p. 943–52.

22

324. Mast, N., A.J. Annalora, D.T. Lodowski, K. Palczewski, C.D. Stout, and I.A. Pikuleva, Structural basis for three–step sequential catalysis by the cholesterol side chain cleavage enzyme CYP11A1. J Biol Chem, 2011. 286(7): p. 5607–13.

325. Mustafi, D., A. Avishai, N. Avishai, A. Engel, A. Heuer, and K. Palczewski, Serial sectioning for examination of photoreceptor cell architecture by focused ion beam technology. J Neurosci Methods, 2011. 198(1): p. 70–6.

326. Mustafi, D., B.M. Kevany, C. Genoud, K. Okano, A.V. Cideciyan, A. Sumaroka, A.J. Roman, S.G. Jacobson, A. Engel, M.D. Adams, and K. Palczewski, Defective photoreceptor phagocytosis in a mouse model of enhanced S–cone syndrome causes progressive retinal degeneration. FASEB J, 2011. 25(9): p. 3157–76.

327. Orban, T., G. Palczewska, and K. Palczewski, Retinyl ester storage particles (retinosomes) from the retinal pigmented epithelium resemble lipid droplets in other tissues. J Biol Chem, 2011. 286(19): p. 17248–58.

328. Palczewski, K., Focus on vision: 3 decades of remarkable contributions to biology and medicine. FASEB J, 2011. 25(2): p. 439–43.

329. Peshenko, I.V., E.V. Olshevskaya, A.B. Savchenko, S. Karan, K. Palczewski, W. Baehr, and A.M. Dizhoor, Enzymatic properties and regulation of the native isozymes of retinal membrane guanylyl cyclase (RetGC) from mouse photoreceptors. Biochemistry, 2011. 50(25): p. 5590–600.

330. Sakami, S., T. Maeda, G. Bereta, K. Okano, M. Golczak, A. Sumaroka, A.J. Roman, A.V. Cideciyan, S.G. Jacobson, and K. Palczewski, Probing mechanisms of photoreceptor degeneration in a new mouse model of the common form of autosomal dominant retinitis pigmentosa due to P23H opsin mutations. J Biol Chem, 2011. 286(12): p. 10551–67.

331. Salon, J.A., D.T. Lodowski, and K. Palczewski, The significance of G protein–coupled receptor crystallography for drug discovery. Pharmacol Rev, 2011. 63(4): p. 901–37.

332. Shiose, S., Y. Chen, K. Okano, S. Roy, H. Kohno, J. Tang, E. Pearlman, T. Maeda, K. Palczewski, and A. Maeda, Toll–like receptor 3 is required for development of retinopathy caused by impaired all–trans–retinal clearance in mice. J Biol Chem, 2011. 286(17): p. 15543–55.

333. Tsybovsky, Y., B. Wang, F. Quazi, R.S. Molday, and K. Palczewski, Posttranslational modifications of the photoreceptor–specific ABC transporter ABCA4. Biochemistry, 2011. 50(32): p. 6855–66.

334. Zhu, Q., W. Sun, K. Okano, Y. Chen, N. Zhang, T. Maeda, and K. Palczewski, Sponge transgenic mouse model reveals important roles for the microRNA–183 (miR–183)/96/182 cluster in postmitotic photoreceptors of the retina. J Biol Chem, 2011. 286(36): p. 31749–60.

335. Amengual, J., M. Golczak, K. Palczewski, and J. von Lintig, Lecithin:retinol acyltransferase is critical for cellular uptake of vitamin A from serum retinol–binding protein. J Biol Chem, 2012. 287(29): p. 24216–27.

336. Cao, P., W. Sun, K. Kramp, M. Zheng, D. Salom, B. Jastrzebska, H. Jin, K. Palczewski, and Z. Feng, Light–sensitive coupling of rhodopsin and melanopsin to G(i/o) and G(q) signal transduction in Caenorhabditis elegans. FASEB J, 2012. 26(2): p. 480–91.

23

337. Chen, Y., E.R. Farquhar, M.R. Chance, K. Palczewski, and P.D. Kiser, Identification and characterization of novel inhibitors of Mammalian aspartyl aminopeptidase. J Biol Chem, 2012.

287(16): p. 13356–70. 338. Chen, Y., K. Okano, T. Maeda, V. Chauhan, M. Golczak, A. Maeda, and K. Palczewski, Mechanism

of all–trans–retinal toxicity with implications for Stargardt disease and age–related macular degeneration. J Biol Chem, 2012. 287(7): p. 5059–69.

339. Gao, S.Q., T. Maeda, K. Okano, and K. Palczewski, A microparticle/hydrogel combination drug–delivery system for sustained release of retinoids. Invest Ophthalmol Vis Sci, 2012. 53(10): p. 6314–23.

340. Golczak, M., P.D. Kiser, A.E. Sears, D.T. Lodowski, W.S. Blaner, and K. Palczewski, Structural basis for the acyltransferase activity of lecithin:retinol acyltransferase–like proteins. J Biol Chem, 2012. 287(28): p. 23790–807.

341. Hachiya, A., B. Marchand, K.A. Kirby, E. Michailidis, X. Tu, K. Palczewski, Y.T. Ong, Z. Li, D.T. Griffin, M.M. Schuckmann, J. Tanuma, S. Oka, K. Singh, E.N. Kodama, and S.G. Sarafianos, HIV–1 reverse transcriptase (RT) polymorphism 172K suppresses the effect of clinically relevant drug resistance mutations to both nucleoside and non–nucleoside RT inhibitors. J Biol Chem, 2012. 287(35): p. 29988–99.

342. Kiser, P.D., E.R. Farquhar, W. Shi, X. Sui, M.R. Chance, and K. Palczewski, Structure of RPE65 isomerase in a lipidic matrix reveals roles for phospholipids and iron in catalysis. Proc Natl Acad Sci U S A, 2012. 109(41): p. E2747–56.

343. Kiser, P.D., M. Golczak, A. Maeda, and K. Palczewski, Key enzymes of the retinoid (visual) cycle in vertebrate retina. Biochim Biophys Acta, 2012. 1821(1): p. 137–51.

344. Latek, D., A. Modzelewska, B. Trzaskowski, K. Palczewski, and S. Filipek, G protein–coupled receptors – recent advances. Acta Biochim Pol, 2012. 59(4): p. 515–29.

345. Maeda, A., M. Golczak, Y. Chen, K. Okano, H. Kohno, S. Shiose, K. Ishikawa, W. Harte, G. Palczewska, T. Maeda, and K. Palczewski, Primary amines protect against retinal degeneration in mouse models of retinopathies. Nat Chem Biol, 2012. 8(2): p. 170–8.

346. Mustafi, D., T. Maeda, H. Kohno, J.H. Nadeau, and K. Palczewski, Inflammatory priming predisposes mice to age–related retinal degeneration. J Clin Invest, 2012. 122(8): p. 2989–3001.

347. Okano, K., A. Maeda, Y. Chen, V. Chauhan, J. Tang, G. Palczewska, T. Sakai, H. Tsuneoka, K. Palczewski, and T. Maeda, Retinal cone and rod photoreceptor cells exhibit differential susceptibility to light–induced damage. J Neurochem, 2012. 121(1): p. 146–56.

348. Orban, T., C.C. Huang, K.T. Homan, B. Jastrzebska, J.J. Tesmer, and K. Palczewski, Substrate–Induced Changes in the Dynamics of Rhodopsin Kinase (G Protein–Coupled Receptor Kinase 1). Biochemistry, 2012. 51: p. 3404–3411.

349. Orban, T., B. Jastrzebska, S. Gupta, B. Wang, M. Miyagi, M.R. Chance, and K. Palczewski, Conformational dynamics of activation for the pentameric complex of dimeric G protein–coupled receptor and heterotrimeric G protein. Structure, 2012. 20(5): p. 826–40.

350. Padayatti, P., G. Palczewska, W. Sun, K. Palczewski, and D. Salom, Imaging of protein crystals with two–photon microscopy. Biochemistry, 2012. 51(8): p. 1625–37.

351. Palczewski, K., Chemistry and biology of vision. J Biol Chem, 2012. 287(3): p. 1612–9. 352. Palczewski, K., Thematic minireview series on focus on vision. J Biol Chem, 2012. 287(3): p. 1610–

1.

24

353. Salom, D., P. Cao, W. Sun, K. Kramp, B. Jastrzebska, H. Jin, Z. Feng, and K. Palczewski, Heterologous expression of functional G–protein–coupled receptors in Caenorhabditis elegans. FASEB J, 2012. 26(2): p. 492–502.

354. Salom, D., B. Wang, Z. Dong, W. Sun, P. Padayatti, S. Jordan, J.A. Salon, and K. Palczewski, Post–translational modifications of the serotonin type 4 receptor heterologously expressed in mouse rod cells. Biochemistry, 2012. 51(1): p. 214–24.

355. Sexton, T.J., M. Golczak, K. Palczewski, and R.N. Van Gelder, Melanopsin is highly resistant to light and chemical bleaching in vivo. J Biol Chem, 2012. 287(25): p. 20888–97.

356. Sundermeier, T.R. and K. Palczewski, The physiological impact of microRNA gene regulation in the retina. Cell Mol Life Sci, 2012. 69(16): p. 2739–50.

357. Tu, X. and K. Palczewski, Crystal structure of the globular domain of C1QTNF5: Implications for late–onset retinal macular degeneration. J Struct Biol, 2012. 180(3): p. 439–46.

358. Maeda, T., Z. Dong, H. Jin, O. Sawada, S. Gao, D. Utkhede, W. Monk, G. Palczewska, and K. Palczewski, QLT091001, a 9–cis–Retinal Analog, Is Well–Tolerated by Retinas of Mice with Impaired Visual Cycles. Invest Ophthalmol Vis Sci, 2013. 54(1): p. 455–66.

359. Zhang, N., A.V. Kolesnikov, B. Jastrzebska, D. Mustafi, O. Sawada, T. Maeda, C. Genoud, A. Engel, V.J. Kefalov, and K. Palczewski, Autosomal recessive retinitis pigmentosa E150K opsin mice exhibit photoreceptor disorganization. J Clin Invest, 2013. 123(1): p. 121–37.

360. Jastrzebska, B., D. Salom, H. Jin, P. Cao, W. Sun, K. Palczewski, and Z. Feng, Expression of Mammalian G Protein–Coupled Receptors in Caenorhabditis elegans. Methods Enzymol, 2013. 520C: p. 239–256.

361. Vahedi–Faridi, A., B. Jastrzebska, K. Palczewski, and A. Engel, 3D imaging and quantitative analysis of small solubilized membrane proteins and their complexes by transmission electron microscopy. J. Electron Microsc (Tokyo), 2013. 62(1):p. 95–107.

362. Jastrzebska, B., T. Orban, M. Golczak, A. Engel, and K. Palczewski, Asymmetry of the rhodopsin dimer in complex with transducin. FASEB J, 2013. 27:p. 1572–1584.

363. Tian, M., Zallocchi M, Wang W–M, Chen C–K, K . Palczewski, Delimont D, Cosgrove D, and Peng Y–W. Light–induced translocation of RGS9–1 and Gβ5L in Mouse Rod Photoreceptors. PLOS ONE 2013. 8(3): e58832.

364. Yan J, S. Kaur, D. DeLucia, C. Hao, J. Mehrens, C. Wang, M. Golczak, K. Palczewski, A. M. Gronenborn, J. Ahn, and J. Skowronski, Tetramerization of SAMHD1 is required for biological activity and inhibition of HIV infection. J. Biol. Chem. 2013. 288:p.10406–10417.

365. Jastrzebska B., P. Ringler, K. Palczewski, and A. Engel, The rhodopsin–transducin complex houses two distinct rhodopsin molecules. J. Struct. Biol. 2013. 182: p. 164–172.

366. Palczewski, K., and P. D. Kiser, As good as chocolate. Science 2013, 340: p. 562–563. 367. Padayatti P.S., L. Wang, S. Gupta, T. Orban, W. Sun, D. Salom, S. Jordan, K. Palczewski, and M. R.

Chance, A hybrid structural approach to analyze ligand binding by the 5–HT4 receptor. Molecular and Cellular Proteomics, 2013. 12: p. 1259–1271.

368. Tsybovsky Y., T. Orban, R. S., Molday, D. Taylor, and K. Palczewski, Molecular organization and ATP–induced conformational changes of ABCA4, the photoreceptor–specific ABC transporter. Structure, 2013. 21: p. 854–860.

369. Kohno, H., Y. Chen, B. M. Kevany, E. Pearlman, M. Miyagi, T. Maeda, K. Palczewski, and A. Maeda: Photoreceptor proteins initiate microglial activation via Toll–like receptor 4 in retinal degeneration mediated by all–trans–retinal. J. Biol. Chem. 2013. 288: p. 15326–15341.

25

370. Mustafi D., B.M. Kevany, X. Bai, T. Maeda, J. E. Sears, A. M. Khalil, and K. Palczewski: Evolutionarily conserved long intergenic non−coding RNAs in the eye. Hum Mol Genetics 2013. 22: p. 2992–3002.

371. Sharma, R., L. Yin, Y. Geng, W. H. Merigan,G. Palczewska, K. Palczewski, D. R. Williams, and J. J. Hunter, In vivo two–photon imaging of the mouse retina. Biomedical Optics Express 2013. 4: p. 1285–1293.

372. Palczewski K, and T. Orban, From Atomic Structures to Neuronal Functions of G protein–coupled receptors (GPCRs). Annu Rev Neurosci 2013. 36: p. 139–164.

373. Helbling R., C. Bolze, M. Golczak, K. Palczewski, A. Stocker, and M. Cascella. Cellular Retinaldehyde Binding Protein – Different Binding Modes and Micro–Solvation Patterns for High–Affinity 9–cis and 11–cis–Retinal Substrates. J Phys Chem. 2013, 117: p. 10719–10729.

374. Du Y., A. Veenstra, K. Palczewski, and T. S. Kern, Photoreceptor cells are major contributors to diabetes–induced oxidative stress and local inflammation in the retina. Proc Natl Acd Sci. 2013: p. 110, 16586–16591.

375. Salom D., P. S. Padayatti, and K. Palczewski, Crystallization of G protein–coupled receptors. Methods in Cell Biology 2013, 117: p. 451–468.

376. Sui, X., P.D. Kiser, J. von Lintig, and K. Palczewski, Structural basis of carotenoid cleavage: from bacteria to mammals. Archives Biochem. Biophys 2012, 539: p. 203–213.

377. Kowatz, T, D. Babino, P. Kiser, K. Palczewski, and J. von Lintig, Characterization of human β,β– carotene–15,15´–monooxygenase (BCMO1) as a soluble monomeric enzyme. Archives Biochem. Biophys 2013, 539: p. 21–222.

378. Mustafi, D, B. M.Kevany, C. Genoud, X. Bai, K. Palczewski. Photoreceptor phagocytosis is mediated by phosphoinositide signaling. FASEB J 2013, 27: p. 4585–4595.

379. Amengual J, M., M. A. K, Widjaja–Adhi, S. Rodriguez–Santiago , S. Hessel, M. Golczak, K. Palczewski, J. von Lintig (2013) Two carotenoid–oxygenases contribute to mammalian pro–vitamin A metabolism. J Biol Chem. 2013, 288: p.34081-34096.

380. Maeda T., M. J. Lee, G. Palczewska, S. Marsili, P. Tesar, K. Palczewski, M. Takahashi, and A. Maeda. Retinal pigmented epithelial cells obtained from human induced pluripotent stem cells possess functional visual cycle enzymes in vitro and in vivo. J. Biol. Chem. 2013. 288, p.34484–34493.

381. Chen Y., G. Palczewska, D. Mustafi, M. Golczak, Z. Dong, O. Sawada, T. Maeda, A. Maeda, and K. Palczewski, Systems pharmacology identifies drug targets for Stargardt disease–associated retinal degeneration. J Clin Invest 2013, 123: p. 5119–5134.

382. Orban T, B. Jastrzebska, and K. Palczewski. Structural approaches to understanding retinal proteins needed for vision. Current Opinion in Cell Biology 2014, 27: p. 32–43.

383. Kevany B.M., Y. Tsybovsky, I.D.G. Campuzano, P. D. Schnier, A. Engel, and K. Palczewski. Structural and functional analysis of the native peripherin/ROM1 complex isolated from photoreceptor cells. J Biol Chem. 2013, 288: p. 36272–36284.

384. Kiser, P. D., M. Golczak, and K. Palczewski, Chemistry of the Retinoid (Visual) Cycle. Chem Rev. 2014, 114: p. 194–232.

385. Bolze CS, R. E. Helbling, R. L. Owen, A. R. Pearson, G. Pompidor, F. Dworkowski, M. R. Fuchs, J. Furrer, M. Golczak, K. Palczewski, M. Cascella, and A.Stocker, Human cellular retinaldehyde–binding protein has secondary thermal 9–cis–retinal isomerase activity. J Am Chem Sci. 2014, 136: p. 137–146.

386. Wu, X., G. Yu , C. Luo, A. Maeda, N. Zhang, D. Sun, Z. Zhou, A. Puntel, K. Palczewski, and Z–R. Lu. Synthesis and evaluation of a nanoglobular dendrimer 5–aminosalicylic acid conjugate with a hydrolyzable Schiff base spacer for treating retinal degeneration. ACS Nano 2014, 8, p.153-161.

26

387. Sakami S, A.V. Kolesnikov, V. J. Kefalov, K. Palczewski. P23H opsin knock−in mice reveal a novel step in retinal rod disc morphogenesis. Human Mol Genetics 2014, 23, p.1723-1741.

388. Sundermeier, R. S., F. Vinberg, D. Mustafi, X. Bai, V. J. Kefalov, K. Palczewski. R9AP overexpression alters phototransduction kinetics in iCre75 mice. Invest Ophthal Visual Sci. 2014, 55, p.1339-1347.

389. Tsybovsky, Y. and K. Palczewski. Expression, purification and structural properties of ABC transporter ABCA4 and its individual domains. Protein Exp and Purif. 2014, 97, p. 50-60.

390. Chen Y., Jastrzebska, B., P. Cao, J. Zhang, B. Wang, W. Sun, Y. Yuan, Z. Feng, K. Palczewski. Inherent instability of the retinitis pigmentosa P23H mutant opsin. J Biol Chem. 2014, 289, p. 9288-9303.

391. Tu, X. and K. Palczewski. The macular degeneration-linked C1QTNF5 (S163) mutation causes higher-order structural rearrangements. J Struct Biol. 2014, 186, p. 186, 86-94.

392. Maeda, A., G. Palczewska, M. Golczak, H. Kohno, Z. Dong, T. Maeda, K. Palczewski. Two−photon microscopy reveals early rod photoreceptor cell damage in light−exposed mutant mice. Proc Natl Acad Sci. 2014, 111, E1428-E1437.

393. Benlian Wang, B., Y. Tsybovsky, K. Palczewski, and M. R. Chance. Reliable Determination of Site–specific in vivo Protein N–Glycosylation based on Collision–Induced MS/MS and Chromatographic Retention Time. J Am Soc Mass Spect. 2014 25, p.729-741.

394. Sui, X, P. D. Kiser, T. Che, P. R. Carey, M. Golczak, W. Shi, J. von Lintig, and K. Palczewski. Analysis of carotenoid isomerase activity in a prototypical carotenoid cleavage enzyme, apocarotenoid oxygenase (ACO). J Biol Chem 2014, 289, 12286-12299.

395. Comar W. D., S. M. Schubert, B. Jastrzebska, K. Palczewski, and A.W. Smith. Mobility and clustering of the opsin G protein-coupled receptor in live cells with time-resolved fluorescence spectroscopy. J Am Chem Soc. 2014, 136, 8342-8349.

396. Palczewska G., Z. Dong, M. Golczak, J. J. Hunter, D.R. Williams, N.S. Alexander, and K. Palczewski. Noninvasive two–photon fluorescence microscopy imaging of mouse retina and RPE through the pupil of the eye. Nature Med. 2014, 20, 785-789.

397. Chen Y., H. Tang, W. Seibel, R. Papoian, K. Oh, X. Li, J. Zhang, M. Golczak, K. Palczewski, and P. D. Kiser. Identification and characterization of novel inhibitors of mammalian aspartyl aminopeptidase. Mol Pharm. 2014, 86, 231-242.

398. Palczewska G, M. Golczak, D.R. Williams, J.J. Hunter, and K. Palczewski. Endogenous fluorophores enable two-photon imaging of the primate eye. Invest Ophthal Visual Sci. 2014, 55, 4438–4447.

399. Sundermeier RT, N. Zhang, F. Vinberg, D. Mustafi, H. Kohno, M. Golczak, X. Bai, A. Maeda, V. J. Kefalov, and K. Palczewski. DICER1 is Essential for Survival of Post-Mitotic Rod Photoreceptor Cells in Mice. FASEB J. 2014, 28, 3780-3791

400. Maeda, A. and K. Palczewski. Retinal degeneration in animal models with a defective visual cycle. Drug Discovery Today: Disease Models. 2014, 10, e163-e172.

401. Yuan S., S. Filipek, K. Palczewski, H. Vogel. Activation of G-protein-coupled receptors correlates with the formation of a continuous internal water pathway. Nat. Commun. 2014, 5:4733 doi: 10.1038/5733.

402. Amengual J., N. Zhang, M. Kemerer, T. Maeda, K. Palczewski, J. von Lintig. STRA6 is critical for cellular vitamin A uptake and homeostasis. Human Mol Genetics 2014, 23, 5402-5417.

403. Sundermeier, T.R., Jin H., Kleinjan M.L., Mustafi D., Licatalosi, D.D., and K. Palczewski. Argonaute HITS-CLIP Reveals a Snapshot of miRNA Gene Regulation in the Mammalian Retina. Biochemistry, 2014, 53, 5831-5833.

404. Palczewski K. The Friedenwald lecture: Chemistry and Biology of the Initial Steps in Vision. Invest Ophthal. Visual Sci. 2014, 55,6651-6672

Introduction. Dr. Arthur S. Polans. Introducing Krzysztof Palczewski, the 2014 recipient of the Friedenwald

27

Award. Invest Ophthal Visual Sci. 2014, 55,6649-6650 405. Baker B.Y, W. Shi, B. Wang, and K. Palczewski. High Resolution Crystal Structures of the Photoreceptor

Glyceraldehyde 3-Phosphate Dehydrogenase (GAPDH) with Three and Four-bound NAD Molecules. Protein Science 2014, 23, 1629-1639.

406. Park, S., C. Li, F. J. Haeseleer, K. Palczewski, and J. B. Ames. Structural Insights into Activation of the Retinal L-type Ca2+ Channel (Cav1.4) by Ca2+-binding Protein 4 (CaBP4). J Biol Chem. 2014, 289, 31262-31273.

407. Yu, G., X. Wu, N. Ayat, A. Maeda, S. Gao, M. Golczak, K. Palczewski, Z-R. Lu. Multifunctional PEG retinylamine conjugate provides prolonged protection against retinal degeneration in mice. Biomolecules 2014,15, 4570-4578.

408. Palczewska G., F. Vinberg, P. Stremplewski, M. P. Bircher, D. Salomǁ, K. Komar, J. Zhang, M. Cascella, M. Wojtkowski,V. J. Kefalov, and K. Palczewski. Human infrared vision is triggered by two−photon chromophore isomerization. Proc Natl Acad Sci. 2014, 111, E5445-E5454.

409. Golczak M., A.E. Sears, P.D. Kiser, and K. Palczewski. LRAT-specific domain facilitates Vitamin A metabolism by domain swapping in HRASLS. Nature Chem Biol. 2014,11, 26-32

410. Mustafi, D., S. Kikano, and K. Palczewski. Serial block face-scanning electron microscopy: a method to study retinal degenerative phenotypes. Current Protocols in Mouse Biology. 2014, 4, 197-204.

411. Salom, D., P. Cao, Y. Yuan, M. Miyagi, Z. Feng, and K. Palczewski. Isotopic labeling of mammalian G protein-coupled receptors (GPCRs) heterologously expressed in Caenorhabditis elegans. Anal Biochem. 2015, 472, 30-36.

412. Puntel A., A. Maeda, M. Golczak, S. Gao, K. Palczewski, Z. Lu. Prolonged prevention of retinal degeneration with retinylamine nanoparticles. Biomaterials 2015, 44, 103-110.

413. Zhang, J., Z. Dong, S. R. Mundla, X. E. Hu, W. Seibel, R. Papoian, K. Palczewski and M. Golczak. Expansion of first-in-class drug candidates that sequester toxic all-trans-retinal and prevent light-induced retinal degeneration. Mol Pharmacol. 2015, 87:477–491

414. Hofmann L. and K. Palczewski. The G protein-coupled receptor rhodopsin: a historical perspective. Methods in Molecular Biology (ed. B. Jastrzebska) 2015, 3-18.

415. Jacobson S. G., A.V. Cideciyan, G.D. Aguirre, A. J. Roman, A. Sumaroka, W.W. Hauswirth, and K. Palczewski. Improvement in vision: a new goal for treatment of hereditary retinal degenerations. Expert opinion on orphan drugs 2015, 3, 1-13

416. Kevany, B. M., N. Zhang, B. Jastrzebska, K. Palczewski. Animals deficient in C2Orf71, an autosomal recessive retinitis pigmentosa-associated locus, develop severe early onset retinal degeneration. Human Mol. Genetics 2015, 24, 2627-2640.

417. Du Y., M. Cramer, C. A. Lee, J. Tang, A. Muthusami D.A. Antonetti, H. Jin., K. Palczewski, and T. S. Kern. Adrenergic and serotonin receptors affect retinal superoxide generation in diabetic mice: relationship to capillary degeneration and permeability. FASEB J 2015, 29, 2194-2204.

418. Chen Y., H. Tang, W. Seibel, R. Papoian, X. Li, N. A. Lambert, K. Palczewski. A high-throughput drug screening strategy for detecting rhodopsin P23H mutant rescue and degradation. Invest Ophthal Visual Sci. 2015, 56, 2553-2567.

419. Baker, B.Y., S. Gulati, W. Shi, B. Wang, P.L. Stewart, K. Palczewski. Crystallization of proteins from crude bovine rod outer segments. Methods in Enzymol. 2015, 557, 439-458.

420. Zhang, N., Y. Tsybovsky, A.V. Kolesnikov, M. Rozanowska, M. Swider, S.B. Schwartz, E.M. Stone, G. Palczewska, A. Maeda, V.J. Kefalov, S. G. Jacobson, A.V. Cideciyan, and K. Palczewski. Protein misfolding and the pathogenesis of ABCA4-associated retinal degenerations. Human Mol Genetics 2015, 24, 3220-3237.

28

421. Kiser PD, J. Zhang, M. Badiee, Q. Li, W. Shi, X. Sui, M. Golczak, G. P. Tochtrop and K. Palczewski. Catalytic mechanism of a retinoid isomerase essential for vertebrate vision. Nature Chem Biol. 2015, 11, 409-415.

422. Yuan, S., K. Palczewski, Q. Peng, M. Kolinski, H. Vogel, and S. Filipek. Ligand specificity of the µ- and κ-opioid receptors, a matter of space. Angewandte Chemie 2015, 54, 7560-7563.

423. Zhang J., P. D. Kiser, M. Badiee, G. Palczewska, Z. Dong, M. Golczak, G. P. Tochtrop, and K. Palczewski. Molecular pharmacodynamics of emixustat in protection against retinal degeneration. J Clin Invest. 2015, 125, 2781-2794.

424. Alexander N.S., G. Palczewska, K. Palczewski. Semi-automated discrimination of retinal pigmented epithelial cells in two-photon fluorescence images of mouse retinas. Biomedical Optics Express, 6, DOI:10.1364/BOE.6.003032

425. Chiang, W-C., H. Kroeger, S. Sakami, C. Messah, D. Yasumura, M.T. Matthes, J.A. Coppinger, K. Palczewski, M.M. LaVail, and J.H. Lin. Robust endoplasmic reticulum-associated degradation of rhodopsin precedes retinal degeneration. Molecular Neurobiology 2015, 52, 679-695

426. Schur R. M., L. Sheng, B. Sahu, G. Yu, S. Gao, X. Yu, A. Maeda, K. Palczewski, Z-R. Lu, Manganese-Enhanced MRI for Preclinical Evaluation of Retinal Degeneration Treatments. Invest. Ophthalmol. Vis. Res. 2015, 56, 4936-4942.

427. Stremplewski, P., K. Komar, K. Palczewski, M. Wojtkowski, G. Palczewska. A periscope for noninvasive two-photon imaging of murine retina in vivo. Biomedical Optics Express 2015, 6, DOI:10.1364/BOE.6.003352

428. Liu, H, J. Tang, Y. Du, C. A. Lee, M. Golczak, A. Muthusamy, D.A. Antonetti, A.A. Veenstra, J. Amengual, J. von Lintig, K. Palczewski, T. S. Kern. Retinylamine benefits early diabetic retinopathy in mice. J. Biol. Chem. 2015, 290, 21568-21579.

429. Jastrzebska, B., Y. Chen, T. Orban, H. Jin, L. Hofmann, K. Palczewski. Disruption of Rhodopsin Dimerization with Synthetic Peptides Targeting an Interaction Interface. J. Biol. Chem. 2015, 290, 25728-25744.

430. Orban, T., W. M. Johnson, Z. Dong, T. Maeda, A. Maeda, T. Sakai, H. Tsuneoka, J. J. Mieyal, K. Palczewski. Serum levels of lipid metabolites in age-related macular degeneration. FASEB J. 2015, 29, 4579-4588.

431. Sahu B., W. Sun, L. Perusek, V.M. Parmar, Y-Z. Le, M. D. Griswold, K. Palczewski, A. Maeda. Conditional Ablation of Retinol Dehydrogenase 10 in the Retinal Pigmented Epithelium Causes Delayed Dark Adaption in Mice. J. Biol. Chem. 2015, 290, 27239-27247

432. Hofmann, L., and K. Palczewski. Advances in Understanding the Molecular Basis of the First Steps in Color Vision. Prog. Retinal and Eye Res. 2015, 49, 46-66.

433. Kolesnikov A., A. Maeda, P. Tang, Y. Imanishi, K. Palczewski, and V. Kefalov. Retinol dehydrogenase 8 and ATP-binding cassette transporter 4 modulate dark adaptation of M-cones in mammalian retina. J. Physiology 2015, 593, 4923-4941

434. Perusek, L., B. Sahu, T. Parmar, H. Maeno, E. Arai, Y-Z. Le, C. S. Subauste, Y. Chen, K. Palczewski, and A. Maeda. A2E Accumulation and the Maintenance of the Visual Cycle are Independent of Atg7-mediated Autophagy in the Retinal Pigmented Epithelium. J. Biol. Chem 2015, 290, 29035-29044.

435. Sun D, H.Maeno, A. Malamas, M. Gujrati, G. Yu, X. Wu, R. Schur, A. Maeda, T. Maeda, K. Palczewski, Z-R. Lu. Self-assembly of a multifunctional lipid with core–shell dendrimer DNA

29

nanoparticles enhanced efficient gene delivery at low charge ratios into RPE cells. Macromolecular Bioscience 2015, 15, 1663-1672.

436. Sui X., M. Golczak, J. Zhang, K. A. Kleinberg, J. von Lintig, K. Palczewski and P. D. Kiser. Utilization of dioxygen by carotenoid cleavage oxygenases. J. Biol. Chem. 2015, 290, 30212–30223

437. Sundermeier R. S., and K. Palczewski. The Impact of miRNA Gene Regulation on the Survival and Function of Mature Cell Types in the Eye. FASEB J. 2016, 30, 23-33.

438. Chen Y., and K. Palczewski. Systems pharmacology links GPCRs with retinal degenerative disorders. Ann Rev Pharmacol and Toxicol. 2016, 56, 273-298.

439. Hofmann L., S. Gulati, A. Sears, P. L. Stewart, K. Palczewski. An effective thiol-reactive probe for differential scanning fluorimetry with a standard RT-PCR device. Anal Biochem 2016, 499, 63-65.

440. Sharma R., D. R. Williams, G. Palczewska, K. Palczewski, J. J. Hunter. Two-photon autofluorescence imaging reveals cellular structures throughout the retina of the living primate eye. Invest. Ophthalmol. Vis. Res. 2016, 57, 62-32-646.

441. Sharma, R., C. Schwarz, D. R. Williams, G. Palczewska, K. Palczewski and J. J. Hunter. In vivo two-photon fluorescence kinetics of primate rods and cones. Invest. Ophthalmol. Vis. Res. 2016, 57, 647-657.

442. Kiser P.D., and K. Palczewski. Retinoids and Retinal Diseases. Ann. Rev. Vision Science 2016 (in press).

443. Babino, D.; Golczak, M.; Kiser, P.; Wyss, A.; Palczewski, K.; von Lintig, J. The biochemical basis of vitamin A3 production in arthropod vision. ACS Chemical Biology 2016 (in press).

444. Alagramam K.N., S. R. Gopal, R. Geng, D. H.-C. Chen, I. Nemet, R. Lee, G. Tian, M. Miyagi, K. F. Malagu, C. J. Lock, W.R. K. Esmieu, A. P. Owens, N. A. Lindsay, K. Ouwehand, F. Albertus, D. F. Fischer, R. W. Bürli, A. M. MacLeod, W.E. Harte, K. Palczewski, Y. Imanishi. A small molecule mitigates hearing loss in a mouse model of Usher syndrome III. Nature Chem Biol. 2016 (in press).

OTHER PUBLISHED ARTICLES 1. Buczylko J, Palczewski K, Kochman M: Purification and properties of brain aldolase C. Intl J Biochem

1983; 15:453–61. 2. Hargrave PA, Palczewski K, Arendt A, Adamus G, McDowell JH: “Rhodopsin and Its Kinase,” In:

Piatigorsky J, Zelenka T, Shinohara T (eds.): Molecular Biology of the Eye: Genes, Vision and Ocular Disease. UCLA Symposium on Molecular and Cellular Biology, New Series, Vol. 88. Copyright © 1988 Alan R. Liss, Inc., New York.

3. Palczewski K, Hargrave PA: “The Phosphorylation of Rhodopsin,” In: Hargrave PA, Hoffmann KP, Kaupp UB (eds.): Mechanism of Phototransduction. Copyright © 1991 Springer–Verlag, New York; pp. 151–59.

4. Palczewski K, Hargrave PA: “The Phosphorylation of Rhodopsin,” In: Hargrave PA, Hofmann KP, Kaupp UB (eds.): Signal Transduction in Photoreceptor Cells. Copyright © 1992 Springer–Verlag, pp. 151–59.

30

5. Buczylko J, Palczewski K: “Purification of Arrestin from Bovine Retinas,” In: Hargrave PA (ed.): Methods in Neurosciences, vol. 15. Copyright © 1993 Academic Press, Inc., New York; Chapter 15: pp. 226–36.

6. Crabb JW, Johnson C, West K, Buczylko J, Palczewski K, Hou J, McKeehan K, Kan M, McKeehan WL, Huddleston MJ, Carr SA: “Analysis of Serine, Threonine and Tyrosine Phosphorylation Sites with Mass Spectrometry,” In: Angeletti RH (ed.): Techniques in Protein Chemistry IV, Section III: “Phosphorylated Proteins.” Copyright © 1993 Academic Press, Inc., San Diego; pp. 171–78.

7. Palczewski K: “Purification of Rhodopsin Kinase from Bovine Rod Outer Segments,” In: Hargrave P (ed.): Methods in Neurosciences, vol. 15. Copyright © 1993 Academic Press, Inc., New York; Chapter 14: pp. 217–25.

8. Palczewski K: “Role of Rhodopsin Kinase and Arrestin in the Quenching of Phototransduction,” In: Shima A et al. (eds.): Frontiers of Photobiology. Copyright © 1993 Elsevier, Amsterdam; pp. 201–04.

9. Palczewski K, Donoso LA: “Arrestin,” In: Haeberli A (ed.): Human Protein Data. Copyright © 1993 VCH Verlagsges. mbH, Weinheim.

10. Kaplan MW, Palczewski K: “pH–Assay of Rod Outer Segment cGMP phosphodiesterase activity,” In: Hargrave PA (ed.): Methods in Neurosciences, vol. 15. Copyright © 1993 Academic Press, Inc., New York; Chapter 13, pp. 205–16.

11. Polans AS, Crabb J, Palczewski K: “Calcium–binding Proteins in the Retina,” In: Hargrave PA (ed): Methods in Neurosciences, vol. 15. Copyright © 1993 Academic Press, Inc., New York; Chapter 17, pp. 248–60.

12. Baehr W, Palczewski K: “Two distinct guanylate cyclase–activating proteins in the mammalian retina.” Proceedings of The Second Great Basin Visual Science Symposium, “Physiological and Molecular Mechanisms of Retinal Function,” 8/25/95, Salt Lake City, Utah, Vol. II, pp. 22–27.

13. Baehr W, Subbaraya I, Gorczyca WA, Palczewski K: “Guanylate cyclase–activating protein (GCAP): A novel Ca2+–binding protein in vertebrate photoreceptors,” In: Anderson RE et al. (eds.): Degenerative Diseases of the Retina. Copyright © 1995 Plenum Press, New York; pp. 339–47.

14. Palczewski K: “Rhodopsin Kinase,” In: Haeberli A (ed.): Human Protein Data. Copyright © 1995 VCH Verlagsges. mbH, Weinheim.

15. Polans AS, Palczewski K, Gorczyca WA, Crabb JW: “Methods for the purification and characterization of calcium–binding proteins from retina,” In: Crabb JW (ed.): Techniques in Protein Chemistry VI. Copyright © 1995 Academic Press, Inc., San Diego; pp. 285–92.

16. Palczewski K, Verlinde CLMJ, Haeseleer F: “Molecular mechanism of visual transduction,” Novartis Foundation Symposium 224, Rhodopsins and Phototransduction. Copyright © Novartis Foundation 1999, published by John Wiley & Sons, Ltd.; pp. 191–207.

17. Palczewski K, Van Hooser JP, Ohguro H: “Identification of residues that are phosphorylated within a receptor,” In: Benovic J (ed.): Regulation of G Protein–coupled receptor function and expression. Copyright © 2000 Wiley–Liss, New York; Chapter 4: pp. 69–91.

18. Maeda T, Imanishi Y, Palczewski K: Rhodopsin phosphorylation: 30 years later. In: Osborne NN and Chader GJ (eds.): Progress in Retinal and Eye Research. © Copyright 2003 Pergamon Press, vol. 22, pp. 417–34.

31

19. Ernst OP, Hofmann KP, Palczewski K: “Vertebrate Rhodopsins” In: Batschuauer A (ed.): Photoreceptors and Light Signaling. Royal Society of Chemistry, Thomas Graham House, Cambridge, U.K. 2003; 3:77–123.

20. Salom D, Li N, Zhu L, Sokal I, Palczewski K: “Purification of the G Protein–Coupled Receptor Rhodopsin for Structural Studies” In: George S and O’Dowd BF (ed): G Protein Coupled Receptor–Protein Interactions. In the series (ed. Sibley D) “Receptor Biochemistry and Methodology”. John Wiley & Sons, Inc. 2005, 1–17.

21. Engel A, Palczewski K: Forward to “The G protein–coupled receptor handbook G protein–coupled receptors – a perspective ”. Humana Press Inc. 2005 (ed. Devi Lakshmi).

22. Palczewski K, Baehr W: “The retinoid cycle and retinal disease” in Nature Encyclopedia of Life Sciences. Macmillan Reference Ltd, 2005, 1–10.

23. Howes KA, Baehr W, Palczewski K: The Retinal Insider. Dry AMD: From Theory to Therapy. Review of Ophthalmology 2006; 67–73.

24. Pulagam LV, Palczewski K: Phototransduction: rhodopsin. In: Darlene A. Dartt, editor. Encyclopedia of the Eye. Vol 3. Oxford: Academic Press. 2010; 403–412.

25. Salom D, Palczewski K: Structural biology of membrane proteins. In "Production of membrane proteins: strategies for expression and isolation." (ed. Anne Skaja Robinson) 2011, 9, 249–273. Wiley–VCH publisher.

26. Lodowski TD, Palczewski K: The impact of G protein–coupled receptor (GPCR) structures on understanding signal transduction, in “G protein–coupled receptors: from structure to function. Giraldo J and Pin Jean–Philippe editors, 2011. The Royal Society of Chemistry. Drug discovery Series No 8. p3–27.

27. Engel A, Palczewski K: Stability and Structural Organization of Rhodopsin in Membrane. Encyclopedia of Biophysics. Editor–in–Chief P. Roberts. Publisher the European Biophysical Societies Association (EBSA) and Springer. Receptor section editor (Ulrike Alexiev) 2012 http://www.springerreference.com/docs/html/chapterdbid/332561.html.).

28. Tsybovsky Y. and K. Palczewski “Retinoid pathway gene mutations and the pathophysiology of related visual diseases” in” The Retinoids: Biology, Biochemistry, and Disease “ (Editors Pascal Dollé and Karen Niederreither). Publisher Wiley–Blackwell. 2015, 529-542

29. CrossTalk: CROSSTALK Krzysztof Palczewski K: Atomic force microscopy (AFM) reveals rhodopsin organization in native disc membranes. In CrossTalk opposing view: Weighing the evidence for class A GPCR dimers, the jury is still out. 2014, J. Physiology. http://jp.physoc.org/content/592/12/2443.short/reply#jphysiol_el_773

30. Orban T., K. Palczewski. Structure and function of G protein-coupled receptor kinases 1 and 7. In “ G protein receptor kinases” (Editorsd V. Gurevich and J. Tesmer). Springer 2016