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Welcoming Letter to 2019 KASBP Spring Symposium
Korean American Society in Biotech and Pharmaceuticals (KASBP) cordially invites you to the “2019 KASBP Spring Symposium” in New Jersey from May 31 to June 1, 2019. This symposium is co-hosted by Hanmi, Yuhan, GC Pharma and SK Biopharmaceuticals and was supported by generous financial supports from our sponsors. The main theme for this year’s Spring Symposium is “Drug Discovery and Development – From Bench to Commercialization”. The symposium organizing committee has invited six outstanding speakers from both academia and pharmaceutical industry, who will share their experience and expertise with the audience. It will be delightful to hear about cutting-edge sciences in COPD pathogenesis, cannabis research and SK R&D as well as advances in protein degrader, anti-sense oligonucleotide, and LBA technology. We are also delighted to
announce Dr. Young-Choon Moon, Vice President at PTC Therapeutics as our distinguished keynote speaker. Dr. Moon is the head of chemistry at PTC he led successful development of Translarna and Risdiplam. This year, KASBP will have a special recognition for Dr. Sechang Kwon, President Hanmi Pharmaceutical, as the recipient of “KASBP Appreciation Award” for his long-standing contribution to pharmaceutical science and the growth of KASBP. We also would like to congratulate ten awardees who were selected for KASBP-Hanmi, KASBP-GC Pharma, KASBP-Yuhan, and KASBP-SKBP Fellowships. Your dedication to the advancement of life-science research inspire us.
Job fair also became a long tradition of KASBP symposium program and many qualified applicants will have an opportunity to interview with prominent Korean pharmaceutical and biotechnology companies. On Saturday evening, an optional special session will be held under the theme of “IND: Regulatory Path and Content”. The session will be led by distinguished panelists from the fields of Regulatory Affair, DMPK and Drug Safety. With these exciting topics and themes, the symposium organizing committee is looking forward to meeting all members and friends in New Jersey!
2018-2019 KASBP President 2019 KASBP Spring Symposium Program Chair
Sean Kim, PhD Wooseok Han, PhD
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2018 – 2019 KASBP OFFICERS
Title Name 한글 이름 Affiliation
President Sean Kim 김승빈 Blueprint Medicines
President Designated K. Stephen Suh 서광순 DiagnoCine
1st Vice President Mooje Sung 성무제 Novartis
Executive Director Wooseok Han 한우석 Novartis
Science Director Hyun-Hee Lee 이현희 Merck
Financial Director Sahee Kim 김사희 RevHealth, LLC
Web Director DaeHo Lee 이대호 Express Care Pharmacy
Human Resource Director Dooyoung Lee 이두영 Morphic Therapeutic
Member Networking Director Claire Jeong Sandy Suh
정가영
서샌디
GSK Exeltis USA
Membership Director So Hyun (Aria) Rhee
Jiyoung Park
이소현
박지영
Rutgers University Golden Healthcare Pharmacy
Public Relations Director Hyunjin Shin 신현진 Takeda
YG Director Ji Eun Lee 이지은 MCPHS
Legal Director Elizabeth Lee 이엘리자베스 Lucas & Mercanti
NJ Chapter President Youngsun Kim 김영선 Adello Biologics
Boston Chapter President Soo-Hee Park 박수희 Novartis
Connecticut Chapter President
Sung-Kwon Kim 김성권 Alexion
Philadelphia Chapter President
Younghoon Oh 오영훈 Spark Therapeutics
San Francisco Chapter President
Hanjo Lim 임한조 Genentech
Washington DC Chapter President
Nam Cheol Kim 김남철 United States Pharmacopeia
Illinois Chapter President Seungwon Chung 정승원 AbbVie
Councilor – Finance/legal Yun H. Choe 최윤 Lucas & Mercanti
Councilor - Grant Hak-Myung Lee 이학명 Shire
Councilor - Auditing Sungtaek Lim 임성택 Sanofi
Councilor - Outreach Yun H. Choe 최윤 Lucas & Mercanti
Councilor – Chair, Advisory Committee
Jae Uk Jeong 정재욱 GSK
Advisory Committee Past KASBP Presidents
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2019 KASBP Spring Symposium Committee
Symposium
Committee Chair Members
Program Committee Wooseok Han
Jae Uk Jeong, Sung-Kwon Kim, Hanjo Lim
Registration Committee Sungki Kim Ji Eun Lee, Melody Park, Hyun-jun Kim, Hye-lim Kim, Ji-min
Son, Joo-hae Kim, Yun Choe
Fellowship Committee Hyun-Hee Lee /
Jennie Jung
KiBum Lee, Hakryul Jo, Mooje Sung, Youngsun Kim
Job Fair Committee Dooyoung Lee Melody Park, Hyunjun Kim
Finance Committee Sahee Kim Yun H. Choe, Youngsun Kim
PR Committee Hyunjin (Gene)
Shin Sean Kim
Graphic Design Jamie Jiyoung Park
On-line Registration and
Web Master Daeho Lee
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Symposium Schedule at a Glance
May 31 (Friday) June 1 (Saturday)
AM 7
Arrival and Check-in
7:30 – 8:30 AM Registration and Breakfast
8 8:30 – 8:45 AM Opening Remarks
8:45 – 10:45 AM Scientific Session A
9
10
10:45 –11:00 AM Coffee Break
11 11:00 – 12:15 PM Fellowship Awards Ceremony
PM 12 12:15 – 12:30 PM Group Photo
12:30 – 2:00 PM Lunch and Poster Session
1
2 2:00 – 3:00 PM Sponsor Presentation
3 3:00-5:30 PM Job Fair 3:00 – 3:15 PM Coffee Break
3:15 – 5:15 PM Scientific Session B
4
5 5:15 – 5:30 PM Scientific Session Closing
Remarks and Break
5:30 – 6:30 PM Registration and
Networking
5:30 – 7:30 PM Dinner and Panel Discussion
(registration required) 6
6:30 – 7:30 PM Opening &Congratulatory
Remarks and Dinner 7
7:30 – 8:00 PM Award Ceremony 7:30 – 8:00 PM Symposium Closing Remarks
8 8:00 – 9:00 PM Keynote Presentation
Have safe trip back home and See you again in the
next symposium!
9 9:00 – 9:10 PM Mentor-Mentee Program
9:10 – 10:00 PM Networking Session
10 10:00 PM - Free Networking
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Symposium Schedule in Detail
May 31, 2019 Friday
Job Fair
3:00 pm ~ 5:30 pm KASBP HR Director, Dooyoung Lee, Morphic Therapeutic
Registration & Networking
5:30 pm ~ 6:30 pm Registration Team
Opening & Congratulatory Remarks and Dinner
6:30 pm ~ 7:30 pm Moderator: Wooseok Han, KASBP Executive Director, Novartis
• Opening Remark KASBP President, Sean Kim, Blueprint Medicines
• Congratulatory Remarks
• Prosperity Toast
• Dinner
Award Ceremony Introduction: Sung Mooje, KASBP Vice President, Novartis
7:30 pm ~ 8:00 pm KASBP Appreciation Award
Awardee: Sechang Kwon, President, Hanmi Pharmaceutical
Keynote Lecture Introduction: Wooseok Han, KASBP Executive Director, Novartis
8:00 pm ~ 9:00 pm RNA Targeting Drug Discovery
Young-Choon Moon, Vice President, PTC Therapeutics
Networking Session
9:00 pm ~ 9:10 pm Mentor-Mentee Program
KASBP YG Director, Ji Eun Lee, MCPHS
9:10 pm ~ 10:00 pm Networking
KASBP President-designate, K. Stephen Suh, DiagnoCine
Moderator
Biology Immuno-oncology/Autoimmune/Inflammatory Kern Chang Respiratory/Metabolic/Cardiovascular/Aging/Mental/Neurogenerative Soo-Hee Park Cell and Gene Therapy/Viral infection/Rare disease Hakryul Jo Chemistry Seungwon Chung PK/PD/pre-clinical/Clinical Science Hanjo Lim BD/Legal/VC Yun H Choe Pharmacy Pharmacy Students can join any group
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June 1, 2019 Saturday
Registration & Breakfast
7:30 am ~ 8:30 am
Opening Remarks
8:30 am ~ 8:45 am KASBP President-designate, K. Stephen Suh, DiagnoCine
Scientific Session A
8:45 am ~ 10:45 am Chair: KASBP-Philadelphia Chapter President, Yonghoon Oh, Spark Therapeutics
• A-1: A Mitochondrial Perspective of COPD Pathogenesis – Focusing on Mitochondrial
Innate Immunity
Min-Jong Kang, Yale University School of Medicine
• A-2: SK Biopharmaceuticals: From R&D to Commercialization
Jeong Woo Cho, SK Biopharmaceuticals
• A-3: New Frontier: Science of Endocannabinoid and Cannabis Research in Drug Development
Dennis Kim, Emerald Health Services
Coffee Break
10:45 am ~ 11:00 am
Fellowship Award Ceremony
11:00 am ~ 12:15 pm KASBP Science Director, Hyun-Hee Lee, Merck
Group Photo time
12:15 pm ~ 12:30 pm
Lunch & Poster Presentation
12:30 pm ~ 2:00 pm
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Sponsor Presentation
2:00 pm ~ 3:00 pm Chair: Connecticut Chapter President, Sung-Kwon Kim, Alexion
• Introduction to Yuhan R&D and Yuhan USA
Yoohoi Park, Director and Sungwoo Ahn, Project Manager
• Introduction to Hanmi Pharmaceuticals R&D
Young-Mi Lee, Executive Director, Head of Global External R&D Innovation
• Introduction of Bridge Biotherapeutics
Yong-Hee Lee, President, Bridge Biotherapeutics, USA and SVP, Head of Development
• Introduction of GC Pharma
Seungkwon Choi, Vice President, Human Resources
Coffee Break
3:00 pm ~ 3:15 pm
Scientific Session B
03:15 am ~ 05:15 pm Chair: Washington-DC Chapter President, Nam Chul Kim, United States
Pharmacopeia
• B-1: Current Progress on Protein Degradation Therapeutics
Hyunsun Jo, Pin Therapeutics
• B-2: Antisense Oligonucleotide Therapeutics for Difficult to Inhibit Drug Targets
Youngsoo Kim, Ionis Pharmaceuticals
• B-3: Critical Ligand-Binding Reagents for Robust Bioanalytical Assays: Characterization
and Lifecycle Management
Hanjo Lim, Genentech
Scientific Session Closing Remarks
5:15 pm ~ 05:30 pm KASBP President, Sean Kim, Blueprint Medicines
Dinner & Panel Discussion "IND: Regulatory Path and Content"
5:30 pm ~ 7:30 pm
• Dinner and Networking (30 min)
• Presentation (60 min)
Regulatory Affair – IND Sandy Suh, Exeltis USA
DMPK Deliverables in Support of IND Filing, Mi-Sook Kim, Takeda
Drug Safety Package to Enable IND Filing, Sean Kim, Blueprint Medicines
• Panel Discussion (30 min)
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KEYNOTE LECTURE
ABSTRACT
RNA Targeting Drug Discovery
Young-Choon Moon, Ph.D.
Vice President, PTC Therapeutics
Biography
Dr. Young-Choon Moon currently serves as the vice president of PTC Therapeutics. Since joining PTC Therapeutics in 2002,
he has discovered and developed various RNA therapeutics including Translarna (PTC124), PTC299, PTC596, and Risdiplam
(RG7916, RO7034067). Prior to joining PTC, he worked as a scientist in Vertex Pharmaceuticals, LG Life Science, and Korea
Research Institute of Chemical Technology for more than 10 years. Upon earning his Ph.D. at University of Illinois, Dr. Moon
joined Prof. E. J. Corey’s laboratory for post-doctoral research at Harvard. He received B.S. in Chemistry and Trade from
Sogang University. Dr. Moon is a founding member of KASBP and has continuously served as president and council member
which have been instrumental in remarkable growth of KASBP.
Abstract
PTC Therapeutics is named for Post Transcriptional Control, and mRNA translation has been a focus of the company for
the past 21 years. We have utilized our GEMS™ (Gene Expression Modulation by Small Molecules) drug discovery platform
to identify small-molecules targeting RNA. I will present several examples of our approaches to successfully identify
compounds that target alternative splicing. I will also highlight our pipeline expansion and future direction for PTC.
KASBP Appreciation Award
Sechang Kwon, Ph.D., President, Hanmi Pharmaceutical Company
With Our Greatest
Appreciation
We Present
Sechang Kwon, Ph.D.
CEO, President
Hanmi Pharmaceutical Company
This Award In Recognition For
Outstanding Contribution To The Growth Of Korean Pharmaceutical Industry
And Inspiration To The Community Of Korean-American Scientists In Kasbp
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SCIENTIFIC SESSION
ABSTRACTS
SESSION A
A-1: A Mitochondrial Perspective of COPD Pathogenesis – Focusing on Mitochondrial Innate Immunity
Min-Jong Kang, M.D., Ph.D.
Professor, Yale University School of Medicine
Biography
Dr. Min-Jong Kang is currently the Director of the Pulmonary Exposure Core at Yale and has active research programs in
basic and translational studies of pulmonary biology/medicine. His early studies demonstrated that the activation of
mitochondrial innate immune signaling plays an important role in the pathogenesis of chronic obstructive pulmonary
disease (COPD). Focusing on mitochondrial innate immune signaling, Dr. Kang's consecutive studies demonstrated that the
nucleotide-binding domain and leucine-rich-repeat-containing protein X1 (NLRX1), a novel mitochondrial molecule, plays
an important inhibitory role in the pathogenesis of COPD. As revealed in this track record, his laboratory has made
meaningful contributions to the advancement of pulmonary medicine/health by providing a better understanding of
mitochondrial damage associated molecular patterns (mitoDAMPs)/mitochondrial dysfunction, which may play a key role
in lung injury/damage responses and consequent pulmonary tissue remodeling pathologies. Dr. Kang earned his M.D.,
Ph.D., and M.P.H. at Seoul National University.
Abstract
Chronic obstructive pulmonary disease (COPD) encompasses several clinical syndromes, most notably emphysema and
chronic bronchitis. Most of the current treatments fail to attenuate severity and progression of the disease, thereby
requiring better mechanistic understandings of pathogenesis to develop disease-modifying therapeutics. A number of
theories on COPD pathogenesis have been promulgated wherein an increase in protease burden from chronic
inflammation, exaggerated production of ROS and the resulting oxidant injury, or superfluous cell death responses caused
by enhanced cellular injury/damage were proposed as the culprit. These hypotheses are not mutually exclusive and
together likely represent the multifaceted biological processes involved in COPD pathogenesis. As known, mitochondrial
function and behavior are fundamental to the physiology of cellular and organismal health, and thus, “mitochondrial
dysfunction” has been implicated in almost every aspect of human health and sickness. In accordance with this, recent
advancements on mitochondrial biology have enabled us to rethink of mitochondrial role in the pathogenesis of COPD and,
hopefully, to illuminate connections between mitochondrial and COPD that could unify multifaceted biological processes
and theories on COPD pathogenesis. These recent scientific advances are reviewed and integrated into a view of COPD
pathogenesis whereby mitochondria play a central role.
A-2: SK Biopharmaceuticals: From R&D to Commercialization
Jeong Woo Cho, Ph.D.
President & CEO, SK Biopharmaceuticals Co., Ltd. & SK Life Science, Inc.
Biography
Dr. Jeong Woo Cho is currently the president and CEO of SK Biopharmaceuticals and SK Life Science. He also served as Chief
Operating Officer (COO) and head of New Drug Business Division of SK Biopharmaceuticals till 2016. Under his leadership,
SK Bio discovered and successfully out-licensed Solriamfetol which was recently approved by FDA for treatment of
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narcolepsy. SKBP is also independently conducting a clinical trial in US with Cenobamate for partial-onset seizures. Dr. Cho
earned his Ph.D. in Biology at the Texas A&M University, College Station, Texas.
Abstract
SK Biopharmaceuticals commenced research and development of new drugs in 1993 as part of our search for the next-
generation growth engine of SK Group. The exciting ascend of SK Biopharmaceuticals began with the acquisition of FDA
approval for clinical test for a new candidate drug substance in 1996. Currently, SK Biopharmaceuticals is conducting basic
research for the development of innovative new drugs at the Bio Science Research Institute in Pangyo, Gyeonggi Province.
Further, SK Life Science Inc. in Fair Lawn, New Jersey, USA, is pursuing global clinical development and direct marketing. In
addition, SK Bio-pharm Tech. Company, Ltd. in Shanghai, China is striving to secure opportunities for strategic alliances in
the development of new drugs. SK Biopharmaceuticals has been leading the development of new innovative drugs
targeting the global market. We aim to grow into a fully integrated global pharmaceutical company (global FIPCO),
equipped with the entire value chain ranging from development and manufacturing to commercialization via our own sales
and marketing organization.
A-3: New Frontier: Science of Endocannabinoid and Cannabis Research in Drug Development
Dennis Kim, M.D., M.B.A.
Chief Medical Officer, Emerald Health Services
Biography
Dr. Dennis Kim is a physician biotechnology executive with specialty training in endocrinology/metabolism spanning
approximately 20 years of drug/product development and corporate strategy experience in the biotech and medical
technology industries. Dr. Kim joined Emerald Health Sciences in March of 2019 as the company's Chief Medical Officer
and has taken a leadership development role across Emerald's portfolio of companies and also brings business
development experience. Prior to this he was Chief Medical Officer at Zafgen for 7.5 years where he oversaw all aspects of
clinical and medical affairs in the field of diabetes, obesity, and rare metabolic/genetic disorders. Prior to joining Zafgen,
Dr. Kim held multiple senior-level positions at Orexigen Therapeutics (Sr. VP of Medical and Clinical Affairs), EnteroMedics
(Chief Medical Officer) and Amylin Pharmaceuticals (Exec Director of Corporate Strategy). He holds an MD from the
University of Health Sciences, The Chicago Medical School, an MBA from UCSD Rady School of Management and a B.S. in
biology from the University of California at Los Angeles. His endocrinology/metabolism specialty fellow training was
completed at UCSD School of Medicine.
Abstract
Cannabis plants have been in existence for millions of years. Human use of cannabis, either for medicinal or recreational
purposes, has been documented for thousands of years. But it is only recently, during the 1990’s, that the endocannabinoid
system (ECS) has been described and endogenous receptors to different components of the cannabis identified. Replete
with social and political stigma and biases, we are at the precipice and inception of scientific pursuit and discovery of this
plant’s chemical, biological, and pharmacological properties and values. The ECS putatively has homeostatic function in
humans, with two major endogenous receptors – CB1 and CB2 – distributed ubiquitously and densely throughout most
organ systems of the human body. These receptors can be engaged with endogenous (e.g. anandamides) or exogenous
ligands (phytocannabinoids, other natural non-cannabis substances, and synthetic analogs of cannabinoids). Comparable
to many other therapeutic or technology platform areas of pharmacologic science, both naturally occurring substances
and new chemical entities (NCEs) are being developed via traditional drug development processes in an attempt to address
a plethora of different ailments. One such marketed product is Epidiolex® (highly purified cannabidiol, or CBD, by GW
Pharmaceuticals) which was FDA approved in June of 2018 for Dravet Syndrome, a rare and treatment resistant seizure
disorder usually diagnosed in children at age 2 or older. Other cannabinoid drug candidates are in development and we
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will undoubtedly witness the arrival of more medicines from this category or better yet, if lucky enough, take part in
meaningfully improving the lives of the patients using this new arsenal in our field.
SESSION B
B-1: Current Progress on Protein Degradation Therapeutics
Hyunsun Jo, Ph.D.
CEO, Pin Therapeutics
Biography
Dr. Hyunsun Jo is an entrepreneur in the biopharmaceutical industry. He is currently a Founder and Chief Executive Officer
at Pin Therapeutics, which is located in South San Francisco and Korea. Pin Therapeutics is backed by many venture capitals
and actively developing integrative drug discovery platform at the field of protein degradation therapeutics using small
molecules. Prior to founding Pin Therapeutics, Dr. Jo has founded two biotech companies called by a LabQnA and an
Embedbio. He obtained his BA and PhD in Molecular Biology (Metabolic Diseases) at Seoul National University and Postdoc
(aging-related diseases) at the Gladstone Institute (UCSF).
Abstract
Pin Therapeutics is aiming at creating therapeutic products based on the monovalent (molecular glue) and bivalent
(PROTAC technology), which utilizes compounds to degrade target proteins within the cell. The typical antibody or small
molecule drug exerts its efficacy by binding to the target protein and inhibiting the function of the protein. Antibodies can
bind to only cell surface targets and are unable to bind to intracellular proteins. While small molecule inhibitors have been
effective with targets like kinase inhibitors, researchers are realizing that it is very difficult to inhibit many types of proteins
with small molecule inhibitors. The protein degradation therapeutics approach can allow us to target these proteins that
are currently considered undruggable. The protein degradation therapeutics can hijack the E3 ligase system and/or
lysosomal degradation to degrade target proteins. Over the last couple of years, the literature has demonstrated the
concept. Molecular glue concept has been approved as a drug. Moreover in vivo efficacy of PROTAC compounds have been
published by a few groups, strengthening the applicability and raising the clinical potential.
Pin Therapeutics is building in-house capability and a network of collaborator to develop protein degradation therapeutics
for basically disease-agnostic. Pin Therapeutics’s uniqueness is largely coming from two aspects: 1. Biological specificity
for target’s degradation hijacking unique E3 ligase complex. 2. Unique technologies that protein degradation therapeutics
can be efficiently developed and a variety of screening assays
B-2: Antisense Oligonucleotide Therapeutics for Difficult to Inhibit Drug Targets
Youngsoo Kim, Ph.D.
Director, Ionis Pharmaceuticals
Biography
Youngsoo Kim, Ph.D. is currently the Director of Oncology at Ionis (formerly known as, Isis) Pharmaceuticals Inc., a
biotechnology company with its focus on RNA-targeted therapy. He obtained his B.S. and M.S. degrees in Biology from
Seoul National University in Seoul, Korea and his doctoral degree from the University of Texas at Austin while working on
his research projects under Dr. Susan M. Fischer at the University of Texas MD Anderson Cancer Center. He joined Dr. John
C. Reed’s lab at the Burnham Institute (now, Sanford Burnham Prebys Medical Discovery Institute) for his postdoctoral
training in 1999, where he investigated the regulatory mechanisms of antiapoptotic proteins in tumor cells. He was the
recipients of Susan G. Komen Breast Cancer and California Breast Cancer Research Postdoctoral fellowships during his
training. He then joined Ionis Pharmaceuticals in 2002 as a senior scientist. Since then, he has been playing a leading role
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in Ionis’ oncology drug discovery program by moving multiple next generation antisense oligonucleotides (ASOs) drugs
into clinical stages, which led to the successful establishment of broad partnerships with AstraZeneca and UT MD Anderson
Cancer Center for target discovery and clinical development for the treatment of highly refractory cancer to current
therapies. He currently serves as a JSC (joint steering committee) member of the Ionis-MDACC collaboration. He is also an
author of > 30 publications in high impact journals and an inventor of the therapeutic applications of multiple ASO targets
in cancer.
Abstract
Our increased understanding on human genome has led to the identification of key disease-causing genes. However, most
of potential drug targets are still intractable by conventional therapeutic approaches. In this regard, RNA-targeted
therapeutics largely represented by antisense oligonucleotides (ASOs) and siRNA have emerged as attractive therapeutic
modalities to overcome the limitation with their specificity and having RNA as their target molecule. Significant advances
made in RNA-targeted therapeutics have led to seven FDA-approved drugs for multiple indications thus far. In this
presentation, first I will provide a brief overview of RNA-targeted therapeutics with a focus on their key differences. Then,
I will cover the evolution of ASO technology, its wide range of mechanism of action, and recent clinical successes of several
drugs for non-oncology indications including SPINRAZA® for the treatment of spinal muscular atrophy (SMA). Finally, I will
present some of highlights from several preclinical and clinical programs Ionis and its partners have been advancing in
oncology, where significant antitumor effects have been observed by next generation (constrained ethyl=cEt) ASOs
targeted to different classes of oncogenic drivers. With these advances in technology, ASO drugs are now poised to be
used to intervene difficult-to-inhibit drug targets for the treatment of a variety of diseases including cancer.
B-3: Critical Ligand-Binding Reagents for Robust Bioanalytical Assays: Characterization and Lifecycle Management
Hanjo Lim, Ph.D.
Scientific Manager, Genentech
Biography
Dr. Hanjo Lim is an expert in analytical characterization of proteins and antibodies for more than 20 years. Dr. Lim is
currently Scientific Manager at BioAnalytical Sciences Department of Genentech since Jan. 2014, where he oversees and
enhances the processes of PK/ADA/PD assay reagent production/characterization/management for Genentech biologics
programs in development as well as influencing scientific directions and leading research activities related to the critical
assay reagents. Prior to joining Genentech, Dr. Lim worked at Sanofi for ~12 years as Principal Research Investigator in
proteomic drug target discovery and characterization of Sanofi biologics drug candidates and also briefly served as Mass
Spec Manager at a startup biosimilar company TPI in Chicago for 1 year. Dr. Lim obtained his BS and MS in Chemistry and
Organic Chemistry respectively from Seoul National University and Ph.D. in Analytical Chemistry (Mass Spectrometry) from
University of Illinois at Chicago.
Abstract
Ligand binding assays (LBAs) are used at almost all stages of the drug development process from discovery to post-
marketing monitoring and have been the industry gold standard bioanalytical methods for PK, PD, and immunogenicity
assessments of protein biologics in clinical trials. Critical reagents are essential components of LBAs whose unique
characteristics impact assay performance. Thus, effective management of the critical reagents is crucial not only to ensure
robust and consistent assay performance throughout the lifetime of the methods but also to minimize the costly delays of
project progression during drug development. Systematic physicochemical and biophysical characterization of these
critical reagents utilizing several key analytical antibody characterization tools including LC-MS and SEC-MALS plays an
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important role in this regard by ensuring batch-to-batch consistency of each supply of the reagents as well as expediting
troubleshooting of the reagents when needed. This talk will discuss critical reagents associated with the key assays
(PK/PD/ADA) used in drug development and then show utility of a couple of key analytical tools that our group is employing
in reagent characterization and troubleshooting.
SATURDAY DINNER & PANEL DISCUSSION
"IND: Regulatory Path and Content"
Regulatory Affair – ‘IND’
Sandy Suh, Pharm.D., Regulatory Affairs, Exeltis
Biography
Sandy Suh is Head of Regulatory Affairs (R&D) at Exeltis USA, Inc. which is part of Insud Pharma. Insud is a global company
established over 40 years ago and provides active pharmaceutical ingredients, generics, biosimilars, and innovative
pharmaceutical products. Since joining the company in 2014, she completed 2 successful NDA approvals: treatment of a
rare disease (Chagas) and a progestin-only pill for female contraception. She maintains PINDs/INDs and has participated in
over 20 Regulatory Agency meetings (mostly with US FDA but also with EMA, MPA in Sweden, MEB in The Netherlands,
and ANMAT in Argentina). The prior 18 years were spent at companies including MannKind, Pfizer/Pharmacia, and Abbott.
She earned her B.S. and Doctor of Pharmacy degrees from the St. Louis College of Pharmacy (St. Louis, MO) and has been
a registered pharmacist since 1995.
Drug Metabolism and Pharmacokinetics (DMPK) Deliverables in Support of IND Filing
Mi-Sook Kim, Ph.D., DMPK, Takeda
Biography
Dr. Mi-Sook Kim is Principal Scientist at Takeda Pharmaceuticals in the department of Drug Metabolism and
Pharmacokinetics (DMPK) based in Boston. Since joining the Takeda in 2006, she has been representing DMPK department
in a cross-functional discovery taskforce, preclinical and clinical development teams in support of small and large molecule
oncology programs. Her primary responsibility at Takeda is to design, coordinate, analyze and interpret the results from
the PK and ADME studies and to contribute in the regulatory filing. Prior to joining Takeda, she supported various drug
discovery and development programs for therapeutic indications including diabetes, obesity, depression, rheumatoid
arthritis, glaucoma, and schizophrenia at the department of Drug Metabolism at Merck & Co., Rahway, NJ. She received
her B.S. in Pharmacy from Seoul National University, Seoul, Korea and obtained her Ph.D. in Biochemistry from Vanderbilt
University, Nashville, Tennessee.
Drug Safety Package to Enable IND Filing
Sean Kim, Ph.D., Quantitative Pharmacology and Drug Safety, Blueprint Medicines
Biography
Sean Kim is Senior Director of Quantitative Pharmacology and Drug Safety at Blueprint Medicines, which is specialized in
applying precision medicines approaches to kinase inhibitor for oncology and rare diseases. Prior to Blueprint, he spent
last 18 years in Bristol-Myers Squibb and Novartis as a safety and DMPK project leader across multiple therapeutic areas,
namely Oncology/IO, Ophthalmology, CNS and Infectious diseases. and multiple modalities, including small molecule, mAb,
SiRNA, anti-sense RNA and bi-specific Ab. He received his Ph.D. in Toxicology at Rutgers, The State of University of New
Jersey.
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POSTER SESSION
AWARDEE ABSTRACTS
2019 SPRING FELLOWSHIP AWARDEES
AWARD NAME AWARDEE SCHOOL
KASBP–Hanmi Fellowship Seung Wook Kim University of Texas at Austin
KASBP–Hanmi Fellowship Kwang-Su Park Ichan School of Medicines at Mt. Sinai
KASBP–Hanmi Fellowship Jooman Park University of Massachusetts
KASBP–Yuhan Fellowship Hyunkyung Jung University of Illinois at Urbana Champaign
KASBP–Yuhan Fellowship Woosook Kim Columbia University
KASBP–Yuhan Fellowship Sungjoon Cho University of Illinois at Chicago
KASBP–GC Pharma Fellowship Hongsuk Park Washington University School of Medicines in St. Louis
KASBP–GC Pharma Fellowship Byungyong Ahn University of Pennsylvania
KASBP–SKBP Fellowship Jung Eun Paik Memorial Sloan Kettering Cancer Center
KASBP-SKBP Fellowship Jeongjoon Choi Yale University
P-1: Regio- and Enantioselective Amination of Branched Allylic Acetates Bearing Linear Alkyl Groups
Seung Wook Kim and Michael J. Krische
University of Texas at Austin, Department of Chemistry (A5300), AUSTIN, TX 78712-0165
E-mail: [email protected]
Transition metal-catalyzed allylic substitution has emerged as
a powerful method for stereoselective C-N bond formation.
Chiral iridium- phosphoramidite complexes have proven
especially effective as catalysts for regio- and enantioselective
allylic amination, but are limited to ARYL- substituted π-allyl
electrophiles. We have demonstrated that π- allyliridium C,O-
benzoate complexes catalyze completely regio- and highly
enantioselective aminations of diverse ALKYL-substituted
allylic electrophiles. Mechanistic studies corroborate C-N bond
formation via outer-sphere addition.
1 Meza, A. T.; Wurm, T.; Smith, L.; Kim, S. W.; Zbieg, J. R.; Stivala, C. E.; Krische, M. J. J. Am. Chem. Soc. 2018, 140, 1275.
2 Kim, S. W.; Schwartz, L. A.; Zbieg, J. R.; Stivala, C. E.; Krische, M. J. J. Am. Chem. Soc. 2019, 141, 671.
3 Kim, S. W.; Schempp, T. T.; Zbieg, J. R.; Stivala, C. E.; Krische, M. J. Angew. Chem. Int. Ed. 2019, Just Accepted.
P-2: Towards discovery of selective molecular probes detecting tau fibrils as non-invasive diagnosis tool for Alzheimer's
disease
Kwang-Su Park
15 | P a g e 2 0 1 9 K A S B P S p r i n g S y m p o s i u m
Icahn School of Medicine at Mount Sinai, New York, USA
Email: [email protected]
Recently, age-related diseases such as Alzheimer’s disease (AD) have gained attention as a serious social problem. However,
there is no single diagnosis system to detect AD. In this context, many approaches to monitor the progression of AD at
early stage have been tried. Among them, near-infrared fluorescence (NIRF) imaging has been proposed as a promising
and non-invasive method to visualize the hallmarks of AD, amyloid β (Aβ) fibrils and aggregated tau, because of its
acceptable depth of penetration and minimal degree of tissue damage. In this study, we focused on the detection of
aggregated tau rather than Aβ fibrils by NIRF imaging because of the proven correlation between the amount of tau protein
load and cognitive impairment in AD patients. In order to develop an NIRF probe against aggregated tau, several known
NIRF probes detecting aggregated tau and Aβ fibrils such as [11C]-PBB3, CRANAD-2, DANIR-2c and MCAAD-3 gave us
perspective for designing molecules. Based on the structures of the characteristic donor-π-acceptor architecture of these
tau-specific probes, various modifications were attempted to optimize the fluorescent properties as well as the tau-
selectivity against Aβ fibrils. Collectively, several promising NIRF probes specifically staining aggregated tau have been
designed and synthesized and evaluated their abilities.
P-3: Role of Interleukn 33 (IL-33) in beige adipocytes
Jooman Park and Silvia Corvera
University of Massachusetts, Medical School, Suite 107, 373 Plantation St, Worcester, MA, USA 01605
E-mail: [email protected]
Uncoupling protein 1 (UCP1) is the critical regulator of thermogenesis in BAT and “brite/beige” adipose tissue. Here we
identify to investigate a possible functional connection between UCP1 and interleukin 33 (IL 33). IL 33 deficiency mice
impeded browning in the cold-exposure stimulation and leads to a decrease the kinetic of Ucp1 mRNA and protein levels.
In addition, glucose and insulin sensitivity is impaired. Moreover, IL 33 expression is remarkably increased upon acute
stimulating forskolin (FSK) as well UCP1 expression in human beige adipocytes. Interestingly, IL 33 is abundance in nucleus
upon acute stimulating FSK. Upon chronic stimulating FSK, IL 33 is secreted. Furthermore, IL 33 overexpression in human
beige adipocytes increases UCP1 expression and protein levels by its secreted. These results reveal a role of IL 33 in
improving energy expenditure via regulating UCP1 protein and given that strengthens its validity as an anti-obesity target.
P-4: Photoacoustic-guided imaging and drug delivery to lung cancer targeted by a peptide probe in K-rasLA2 mutant
mice
Hyunkyung Jung1,2, Yu-Kyoung Oh4, In-San Kim5, Chulhong Kim3*, Byungheon Lee2*
1Department of Molecular & Integrative Physiology, University of Illinois at Urbana-Champaign, Urbana, IL 61801. 2CMRI,
School of Medicine, Kyungpook National University, 680 Gukchaebosang-ro, Jung-gu, Daegu 41944, Republic of Korea.
3Departments of Creative IT Engineering and Electrical Engineering, Pohang University of Science and Technology, 77
Cheongam-Ro, Nam-Gu, Pohang, Gyeongbuk 37673, Republic of Korea. 4College of Pharmacy, Seoul National University, 1
Gwanak-ro, Gwanak-gu, Seoul 08826, Republic of Korea. 5Biomedical Center, Korea Institute of Science and Technology, 5
Hwarang-ro 14 gil, Seongbukgu, Seoul 02792, Republic of Korea.
E-mail: [email protected]
16 | P a g e 2 0 1 9 K A S B P S p r i n g S y m p o s i u m
The lack of molecular targets and targeting probes remains a major drawback in targeted imaging and drug delivery for
lung cancer. In this study, we exploited in vivo phage display to identify a novel targeting probe that homes to the tumor
in a K-rasLA2 mutant mouse lung cancer model. Compared with other candidate peptides selected from five rounds of
phage display, the CRQTKN peptide homed to tumor nodules in the lung of mutant mice at higher levels. Photoacoustic
tomography of mutant mice detected lung tumors via tumor homing of the nearinfrared fluorescence dye-labeled CRQTKN
peptide. Ex vivo photoacoustic images of isolated organs further demonstrated tumor homing of the CRQTKN peptide,
while minimal accumulation was observed in control organs, such as the liver. Compared with untargeted liposomes,
doxorubicin-loaded liposomes surface modified with the CRQTKN peptide more efficiently delivered doxorubicin and
reduced the number of tumor nodules measuring >3 mm in diameter. Affinity-based identification was used to detect
tumor necrosis factor receptor superfamily member 19L (TNFRSF19L), which was up-regulated in lung tumors of mutant
mice, as the receptor for the CRQTKN peptide. In conclusion, these results suggest that the CRQTKN peptide is a promising
targeting probe for photoacoustic-guided detection and drug delivery to lung cancer, and acts by binding to TNFRSF19L as
a novel molecular target.
P-5: PD-1/PD-L1 axis drives gastric tumorigenesis with tumor-infiltrating myeloid-derived suppressor cells
Woosook Kim, Timothy Chu, Henrik Nienhueser, Zhengyu Jiang, Yoku Hayakawa, James Fox, Charles Drake and Timothy
Wang
Department of Medicine, Columbia University Medical Center, 1130 St. Nicholas Avenue, Room 901, New York, NY 10032
E-mail: [email protected]
Advanced gastric cancer is difficult to cure with chemotherapy or radiation therapy. Therefore, new therapeutic
approaches are clearly needed. Recent clinical studies of anti-PD-1 agents showed promising activity in a subset of gastric
cancer patients but the biological roles of PD-1/PD-L1 in gastric cancer have not been well elucidated. Here we evaluated
the efficacy of PD-1 blockade in mouse models of gastric cancer and examined the role of PD-L1 in gastric tumorigenesis.
Gastrin-deficient (GAS-KO) and H/K-APTase-IL-1b mice received Helicobacter felis and N-methyl-N-nitrosourea (MNU) to
induce large antral tumors and were treated with anti-PD-1 (mDX400, the murine analog against pembrolizumab) or
isotype antibody (10 mg/kg IP qw) in early and late treatment regimens. Tumors developed in GAS-KO are PD-L1+ and had
higher mutation rates than those in wild-type mice. GAS-KO receiving anti-PD-1 early exhibited a significant reduction in
tumor burden with increased CD8+ T cells and a remarkable decrease in myeloid-derived suppressor cells (MDSCs) within
the tumor. However, IL-1b mice showed resistance to anti-PD-1 despite increased T cell infiltration, which may due to a
high level of MDSCs recruited by constitutively secreted IL-1b from gastric parietal cells. Moreover, delayed anti-PD-1 did
not suppress growth of established tumors in GAS-KO and IL-1b mice with robust expansion of MDSCs in tumors.
Chemotherapy, 5-fluorouracil (30 mg/kg IP q2w) and oxaliplatin (5 mg/kg IP q2w), dramatically reduced MDSCs and
increased the response rate of gastric cancer to PD-1 blockade but caused PD-L1 overexpression on tumor cells mediating
immune evasion and resistance to checkpoint inhibition. To further explore the role of PD-L1 on gastric tumor and immune
cells, we generated knockin mice which conditionally express mouse Pdl1 gene. Tff2-Cre; R26-PD-L1 and LysM-Cre; R26-
PD-L1 mice expressed a high level of PD-L1 in the gastric epithelium and myeloid cell lineage, respectively. Overexpression
of PD-L1 on both gastric epithelial and myeloid cells markedly promoted tumor growth by MNU, which was accelerated by
Helicobacter infection. In contrast to LysM-Cre; R26-PD-L1 mice, Tff2-Cre; R26-PD-L1 mice showed higher tumor incidence
17 | P a g e 2 0 1 9 K A S B P S p r i n g S y m p o s i u m
to MNU, implicating epithelial-derived PD-L1 increases susceptibility to carcinogen and accelerates tumor progression.
Upregulation of PD-L1 expression in myeloid cells facilitated tumor progression with enhanced suppression of CD8+ T cells.
These findings elucidate the interplay between growing tumors and immune system to evade anti-tumor activity.
Combinatorial treatments of PD-1 blockade with effective MDSC targeting are needed to further improve anti-tumor
efficiency in gastric cancer patients.
P-6: Commensal gut microbiota modulates susceptibility to acetaminophen-induced hepatotoxicity
Sungjoon Cho1, Kyoung-Jae Won2, Vanessa Leone4, Eugene B. Chang4, Hyunwoo Lee3, Hyunyoung Jeong1,2
1Department of Biopharmaceutical Sciences, 2Department of Pharmacy Practice, 3Department of Medicinal Chemistry and
Pharmacognosy, College of Pharmacy, University of Illinois at Chicago; 4Department of Medicine, University of Chicago,
Chicago, IL, USA
E-mail: [email protected]
Overdose of acetaminophen (APAP) causes fulminant liver injury in humans. However, individual susceptibility to APAP-
induced liver toxicity (APAP toxicity) highly varies, and the risk factor(s) for the susceptibility remain unclear. In this study,
we explored a potential role of gut microbiota in modulating the susceptibility to APAP toxicity. C57BL/6 mice from two
different vendors [Jackson (JAX) and Taconic (TAC)] are known to have different gut microbiota. These conventional mice
were dosed with APAP (300 mg/kg, i.p), and alanine aminotransferase (ALT) levels in the serum (as a marker for liver injury)
were measured 24 h post-dosing. ALT activity in TAC mice was significantly higher than that in JAX mice. Interestingly, the
difference in APAP toxicity between JAX and TAC mice was abrogated when these mice were cohoused for 4 weeks and
treated with APAP (300 mg/kg, i.p). Moreover, germ-free C57BL/6 mice, when conventionalized with respective cecum
materials of JAX and TAC mice, exhibited similar APAP susceptibility patterns as seen with conventional JAX and TAC mice.
To determine the underlying mechanism of gut microbiota-mediated alteration in APAP toxicity, time course experiments
were performed using JAX and TAC mice. TAC mice exhibited faster and higher APAP-protein adduct level suggesting higher
metabolism of APAP to toxic reactive metabolite. The hepatic expression levels of CYP2E1 and CYP1A2, the major enzymes
mediating APAP bioactivation to a toxic metabolite, were similar between JAX and TAC mice. Hepatic concentrations of
APAP and APAP-GSH conjugate were also similar suggesting that APAP exposure and detoxification of toxic metabolite by
glutathione (GSH) were similar between JAX and TAC mice. Altogether, these data suggest that differential gut microbiota
modulate susceptibility to APAP toxicity potentially by altering metabolism of APAP to toxic metabolite which is not
mediated by altering CYP2E1 expression, hepatic APAP exposure and detoxification of toxic metabolite by GSH.
P-7: Role of Peroxisomes in Mitochondrial Dynamics and Adipose Tissue Thermogenesis
Hongsuk Park1, Anyuan He1, Min Tan1, Jordan M. Johnson2, John M. Dean1, Terri A. Pietka3, Yali Chen1, Xiangyu Zhang4,
Fong-Fu Hsu1, Babak Razani4, Katsuhiko Funai2, and Irfan J. Lodhi1*
1Division of Endocrinology, Metabolism and Lipid Research, Department of Medicine, Washington University School of
Medicine, Saint Louis, MO 63110, USA; 2Diabetes & Metabolism Research Center, University of Utah, Salt Lake City, UT
84112, USA; 3Nutrition and Geriatrics Division; 4Cardiology Division, Department of Medicine, Washington University
School of Medicine, Saint Louis, MO 63110, USA
E-mail: [email protected]
18 | P a g e 2 0 1 9 K A S B P S p r i n g S y m p o s i u m
Peroxisomes perform essential functions in lipid metabolism, including fatty acid oxidation and plasmalogen synthesis.
Here, we describe a role for peroxisomal lipid metabolism in mitochondrial dynamics in brown and beige adipocytes.
Adipose tissue peroxisomal biogenesis was induced in response to cold exposure through activation of the thermogenic
co-regulator PRDM16. Adipose-specific knockout of the peroxisomal biogenesis factor Pex16 impaired cold tolerance,
decreased energy expenditure, and increased diet-induced obesity. Pex16 deficiency blocked cold-induced mitochondrial
fission, decreased mitochondrial copy number, and caused mitochondrial dysfunction. Adipose-specific inactivation of
peroxisomal beta-oxidation was not sufficient to affect adiposity, thermogenesis or mitochondrial copy number, but
disruption of plasmalogen synthesis recapitulated the effects of Pex16 knockout on mitochondrial morphology.
Plasmalogens are present in mitochondria and decreased with Pex16 inactivation. Their dietary supplementation increased
mitochondrial copy number, improved mitochondrial function, and rescued thermogenesis in Pex16 knockout mice. These
findings support a surprising interaction between peroxisomes and mitochondria to regulate mitochondrial dynamics and
thermogenesis. Manipulating the production of peroxisome-derived lipids, plasmalogens, by dietary or pharmacological
means could improve the thermogenic feature of adipocytes as a promising strategy for treating metabolic syndrome.
P-8: MondoA Signaling Links Skeletal Muscle Lipid Accumulation and Insulin Resistance
Byungyong Ahn1 and Daniel P. Kelly1,2
1Cardiovascular Institute and 2Institute for Diabetes, Obesity and Metabolism, Perelman School of Medicine, University of
Pennsylvania, Philadelphia, Pennsylvania 19104, USA
E-mail: [email protected]
It is well known that insulin resistance in the obese state is associated with accumulation of neutral lipid in extra-adipose
tissues. This phenomenon is particularly well-documented in skeletal muscle. The mechanistic underpinnings of this
linkage are not fully understood. We hypothesized that fundamental homeostatic mechanisms exist to coordinately control
cellular lipid stores and insulin-mediated glucose uptake. Previously, using a small molecule phenotypic screen, we found
that the transcription factor MondoA inhibits muscle insulin signaling via activation of TXNIP (a known suppressor of insulin
signaling) and increases neutral lipid stores through an unknown mechanism. Current studies conducted in human skeletal
myotubes demonstrated that nutrient loading with glucose activated MondoA by triggering its localization to the nucleus.
Conversely, glucose starvation of myocytes led to nuclear exclusion of MondoA. Expression of TXNIP, and the related factor
ARRDC4, was regulated in accordance with nuclear levels of MondoA. These results indicated that in conditions of nutrient
(glucose) loading, MondoA serves to deactivate insulin signaling and reduce glucose uptake to prevent cellular nutrient
overload. Whole genome RNA-seq and ChIP-seq studies demonstrated that MondoA activates target genes involved in
nutrient storage pathways (TAG and glycogen synthesis) and insulin signaling. In addition, MondoA regulates KLF10 and
KLF11, known regulators of glucose homeostasis. Muscle-specific genetic deletion of MondoA in mice was shown to
improve glucose tolerance in the context of diet-induced obesity. We conclude that MondoA plays a key role as a cellular
transcriptional checkpoint to control nutrient catabolism by suppressing insulin signaling and shuttling fatty acids into
triglyceride stores during conditions of “plenty”. In the context of chronic activation of MondoA (caloric excess), a vicious
cycle of myocyte lipid accumulation and insulin resistance ensues. Accordingly, MondoA signaling is a candidate target for
strategies aimed at reducing insulin resistance and cellular lipotoxicity.
19 | P a g e 2 0 1 9 K A S B P S p r i n g S y m p o s i u m
P-9: Fusobacterium nucleatum promotes colorectal cancer by inducing Wnt/β-catenin modulator Annexin A1
Jung Eun Baik, Mara Roxana Rubinstein, Yiping W Han
Division of Periodontics, College of Dental Medicine, Columbia University, New York, NY, USA
E-mail: [email protected]
Fusobacterium nucleatum, a Gram-negative oral anaerobe, is a significant contributor to colorectal cancer. Using an in vitro
cancer progression model, we discover that F. nucleatum stimulates the growth of colorectal cancer cells without affecting
the pre-cancerous adenoma cells. Annexin A1, a previously unrecognized modulator of Wnt/β-catenin signaling, is a key
component through which F. nucleatum exerts its stimulatory effect. It is specifically expressed in proliferating colorectal
cancer cells and involved in activation of cyclin D1. Annexin A1 expression level in colon cancer is a predictor of poor
prognosis independent of cancer stage, grade, age and sex. The FadA adhesin from F. nucleatum up-regulates Annexin A1
expression through E-cadherin. A positive feedback loop between FadA and Annexin A1 is identified in the cancerous cells,
absent in the non-cancerous cells. We therefore propose a “two-hit” model in colorectal carcinogenesis, with somatic
mutation(s) as the first hit, and F. nucleatum as the second hit exacerbating cancer progression after benign cells become
cancerous. This model extends the “adenoma-carcinoma” model and identifies microbes such as F. nucleatum as cancer
“facilitators”.
P-10: How pathogens utilize their new genetic tools?
Jeongjoon Choi
Department of Microbial Pathogenesis, Yale School of Medicine, New Haven, CT, USA
E-mail: [email protected]
Horizontal gene transfer plays a critical role in bacterial evolution. Horizontally transferred genes often provide new
properties to an organism such as the utilization of carbon sources, resistance to antibiotics, and virulence. The heat-
stable nucleoid structuring (H-NS) protein silences transcription of foreign genes in a variety of Gram-negative bacterial
species. Because H-NS amounts are believed to remain constant, overcoming gene silencing has been largely ascribed to
DNA binding proteins that outcompete H-NS for binding to AT-rich foreign DNA or that form non-functional oligomers with
H-NS. We now report that the intracellular pathogen Salmonella enterica degrades H-NS when inside macrophages,
reducing H-NS amounts 16 fold. We identify Lon as the protease degrading H-NS, and show that Lon’s action lowers H-NS
binding to foreign DNA, thereby increasing the mRNA amounts of the corresponding genes. The DNA binding protein PhoP
promotes H-NS proteolysis by displacing H-NS from DNA, resulting in expression of foreign genes – even those whose
regulatory sequences are not bound by PhoP. The uncovered mechanism allows expression multiple foreign genes without
the need to evolve binding sites for anti-silencing proteins at each foreign gene. Our findings suggest that alteration of
foreign gene silencer could hamper bacterial pathogenesis.
20 | P a g e 2 0 1 9 K A S B P S p r i n g S y m p o s i u m
PAST AWARDEES
KASBP-DAEWOONG ACHIEVEMENT
2009 Jong Eun KIM (Gilead Sciences, Inc.), (Kainos Medicine Inc, Korea, Current)
2010 David C. CHU, (University of Georgia)
2011 Sung Ho KIM (University of California, Berkeley)
2012 Dennis CHOI (Stony Brook Medicine and Stony Brook University)
2013 Joseph KIM (Inovio Pharmaceuticals)
2014 Kinam PARK (Purdue University)
2015 Jong Sung KOH (Genoscco)
2016 Jang-Ho CHA (Novartis)
2017 Peter PARK (Bicycle Therapeutics)
2018 Jong Wook LEE (Daewoong Pharmaceuticals)
KASBP RECOGNITION AWARD
2015 Jong Wook LEE (Daewoong)
KASBP-DAEWOONG FELLOWSHIP
2006 JaeKi MIN (New York University), Hahn KIM (Princeton University), HyeJin PARK (Rutgers University)
2007 JiSook MOON (Harvard University), SungYeon PARK (Rutgers University), SeokGeun LEE (Columbia
University)
2008 HeungKyu LEE (Yale University), JungHwan KIM (Rutgers University), MinSik KANG (Columbia University)
2009 JinAh PARK (Harvard University), JaeMin CHOI (Yale University), DeokHo KIM (Johns Hopkins University)
2010 JungMin KEE (Rockefeller University), HyungWook KIM (NIH), SeJin AHN (Harvard University)
2011 MooRi HAN (University of California, LA), HwanJong JANG (Boston College)
2012 JeongHo JANG (Columbia University), JaeWoo CHOI (Oregon State University)
2013 JangEun LEE (University of Pennsylvania), Eun Chan PARK (Rutgers University)
2014 Kimberly H. KIM (Harvard University), Seung Koo LEE (Weill Cornell Medical College), Min-Sik KIM (Johns
Hopkins University)
2015 Jiyeon KIM (UT Southwestern), Sun Mi PARK (Memorial Sloan-Kettering Center); Byeong Seon KIM
(University of Pennsylvania)
2016 Sang Bae LEE (Columbia University), Junil KIM (University of Pennsylvania), Ho-Keun KWON (Harvard
Medical School)
2017 KyeongJin KIM (Columbia University Medical Center), Min-Ji BAK (Ernest Mario School of Pharmacy),
Heung Sik HAHM (Free University Berlin)
2018 Jung Ho HYUN (Max-Planck Florida Institute for Neuroscience), Seung Hoon LEE (Harvard Medical
School), Jang Hwan CHO (Boston University)
21 | P a g e 2 0 1 9 K A S B P S p r i n g S y m p o s i u m
KASBP-GC Pharma (formerly GREEN CROSS) FELLOWSHIP
2011 HanSang CHO (Harvard Medical School), SungWoong KANG (Johns Hopkins University), MiYeon KIM
(Columbia University), JaeYoung SOH (Rutgers University), SungYong HWANG (NIEHS/NIH)
2012 WonJin CHO (Drexel University), HyoJung KANG (Yale University), JungHyun LEE (Columbia University),
YongJae LEE (Yale University), JaeHyun YOON (NIH)
2013 Yunjong LEE (Johns Hopkins University), Jun-Dae KIM (Yale University), Bae-Hoon KIM (Yale University),
Ja Young KIM-MULLER (Columbia University)
2014 Catherine RHEE (University of Texas at Austin), Ji-Seon SEO (The Rockefeller University) Sehyun KIM (New
York University)
2015 Young-Su YI (New York University), Hee-Woong LIM (University of Pennsylvania), Bloria Bora KIM (The
Pennsylvania State University)
2016 Eui Tae KIM (University of Pennsylvania), Kihyun LEE (Weill Cornell Medical Science)
2017 Seung-Yeol PARK (Harvard medical school), Young Bok Abraham KANG (Harvard medical school)
2018 Jae Yeon HWANG (Yale University), Youngjin KIM (Rockefeller University)
KASBP-HANMI FELLOWSHIP
2011 HyungJin AHN (Rockefeller University), ChangHoon CHO (Abramson Research Center)
2012 YuNa KIM (University of North Carolina), HyunSeob TAE (Yale University), InHye LEE (NIH)
2013 JooHee LEE (Memorial Sloan-Kettering Cancer Center), KyungRyun LEE (Rutgers University), ManRyul LEE
(Indiana University)
2014 Young Chan CHA (Wistar Institute), Min-Kyu CHO (New York University), Lark Kyun KIM, (Yale University),
Yu Shin KIM (Johns Hopkins University)
2015 Seonil KIM (New York University), Peter B. KIM (Yale University)
2016 Sungwhan OH (Harvard Medical School), Won-Gil LEE (Yale University), Hee-Jin JEONG (Harvard Medical
School)
2017 Seungkyu LEE (Harvard Medical School), Soo Seok HWANG (Yale University), Heeoon HAN (University of
Pennsylvania)
2018 Jae Yeon HWANG (Yale University), Yeong Shin YIM (MIT), Dahea YU (Rutgers University)
KASBP-LG CHEM FELLOWSHIP
2017 Kyoung-Dong KIM (Wistar Institute), Seok-Man HO (Icahn School of Medicine at Mount Sinai)
2018 Kisa SUNG (Icahn School of Medicine at Mount Sinai), Gihoon LEE (University of Chicago)
KASBP-QURIENT FELLOWSHIP
2018 Soeun KANG (University of Illinois at Chicago), Do Hyung KIM (Johns Hopkins University)
22 | P a g e 2 0 1 9 K A S B P S p r i n g S y m p o s i u m
KASBP-YUHAN FELLOWSHIP
2011 KiYoung KIM (Boston University), JoongSeop SHIM (Johns Hopkins University)
2012 YeMin HUH (University of Michigan), SookHee BANG (University of Pennsylvania), JungHo BAIK (Columbia
University)
2013 Dong Jun LEE (University of Chicago), Ingyu KIM (Yale University), Ja Yil LEE (Columbia University)
2014 Seouk Joon KWON (Rensselaer Polytech Institute), Jeongmin SONG (Yale University), Jae-Hyun YANG
(Harvard Medical School), Wan Seok YANG (Columbia University)
2015 Min-Joon HAN (Harvard Medical School), Minjung KANG (Cornell University)
2016 Ki Su KIM (Harvard Medical School), Hongjae SUNWOO (Harvard Medical School), Seo-Young PARK
(University of Massachusetts)
2017 Hanseul YANG (Rockefeller University), Ji-Hoon PARK (NIH), Hong-Yeoul RYU (Yale University)
2018 Sangdoo KIM (Harvard Medical School), Baehyun SHIN (Harvard Medical School), Mikyung YU (Harvard
Medical School)
KASBP-ST PHARM FELLOWSHIP
2016 Jung-Eun JANG (New York University), Byungsu KWON (MIT)
KASBP FELLOWSHIP
2009 SangHo CHOI (NIH)
2010 SangRyung KIM (Columbia University), TaeSook YOON (Rutgers University), EunMi HUH (Cal. Tech.)
2015 Mi Jung KIM (Duke University), Minyoung PARK (The Rockefeller University)
2018 Sinyoung JEONG (Harvard Medical School), Young Eun LEE (Monell Chemical Senses Center)
KASBP-KSEA FELLOWSHIP
2013 Sung In LIM (University of Virginia)
2014 Keun-woo JIN (Temple University)
KASBP-KUSCO FELLOWSHIP
2008 HyunHo KIM (National Institutes of Health), TaekBeom OHN (Harvard Medical School), WonAh JOO
(Wistar Institute)
KASBP-KRICT FELLOWSHIP
2009 SeungSik SHIN (Rutgers University), EunJoo JEONG (Columbia University), KyuWon BAEK (University of
Pennsylvania)
KASBP-KHIDI FELLOWSHIP
2010 JaeHyun BAE (Yale University), HeeYeon CHO (Boston College)
23 | P a g e 2 0 1 9 K A S B P S p r i n g S y m p o s i u m
KASBP-DAEWOONG SCHOLARSHIP
2006 Jin K. PAI, Schering-Plough (Handok Pharmaceuticals, Korea, Current)
2007 YoungWhan PARK, Merck (National Cancer Center, Korea, Current)
2008 Young-Choon MOON (PTC Therapeutics)
2009 HongYong KIM (Novartis)
24 | P a g e 2 0 1 9 K A S B P S p r i n g S y m p o s i u m
2019 KASBP Spring Symposium Attendees
Last name First name 한글 이름 Affiliation Group Networking
1. Ahn Byungyong 안병용 University of Pennsylvania
2. Ahn Kyonghoon 안경훈 Daewoong pharmaceutical company, Bio-research cencer
Immuno-oncology/Autoimmune/Inflammatory
3. Ahn Sungwoo 안성우 Yuhan USA BD/Legal/VC:
4. AN YOUNGTAE 안영태 DGMIF
5. Aoyagi Kazuko Celerion Inc Respiratory/metabolic/cardiovascular/Aging/mental/Neurogenerative
6. Bae Jihyun 배지현 Rutgers University Pharmacy
7. Baik Jungeun 백정은 Memorial Sloan Kettering Cancer Center
Respiratory/metabolic/cardiovascular/Aging/mental/Neurogenerative
8. Chang Kern 장건희 Janssen R&D LLC. Immuno-oncology/Autoimmune/Inflammatory
9. Chang Rae Sung 장래성 Access Bio, Inc. PK/PD/pre-clinical/Clinical Science:
10. Cho Jeong Woo 조정우 SK Biopharmaceuticals
11. CHO SUNG YUN 조성윤 Weill Cornell Medicine Respiratory/metabolic/cardiovascular/Aging/mental/Neurogenerative
12. Cho Sungjoon 조성준 University of Illinois at Chicago PK/PD/pre-clinical/Clinical Science:
13. Cho Woong Hee 조웅희 UT Southwestern Medical Center Cell and Gene Therapy/Viral infection/Rare disease
14. Cho Yong 조용성 YC Consulting BD/Legal/VC:
15. Choe Yun H. 최윤 Lucas and Mercanti, LLP BD/Legal/VC:
16. Choi Barlgum 최밝음 Alexion Pharmaceuticals Cell and Gene Therapy/Viral infection/Rare disease
17. Choi Jeea 최지아 Novartis Immuno-oncology/Autoimmune/Inflammatory
18. Choi Jeongjoon 최정준 Yale University Cell and Gene Therapy/Viral infection/Rare disease
19. Choi Junyong 최준용 Queens College - CUNY Chemistry
20. Choi Seungkwon 최승권 GC Pharma (GC녹십자)
21. Choi Yongjin 최용진 Regeneron Pharmaceuticals, Inc. BD/Legal/VC:
22. Choo Min-Kyung 추민경 Takeda Immuno-oncology/Autoimmune/Inflammatory
23. Chung DaEun 정다은 Rutgers University Pharmacy
24. Chung HaeWon 정해원 Asimov Cell and Gene Therapy/Viral infection/Rare disease
25. Chung Seung Wook 정승욱 Boehringer Ingelheim PK/PD/pre-clinical/Clinical Science:
26. Chung Seungwon 정승원 AbbVie Chemistry
27. HAHM Sean 함성원 The Yakup Shinmoon
28. Han Celine Garam 한가람 BMS (Bristol-Myers Squibb) Immuno-oncology/Autoimmune/Inflammatory
29. HAN DAE 한대엽 YALE UNIVERSITY
30. Han Wooseok 한우석 Novartis Institutes for BioMedical Research
Chemistry
31. Han Yong-Hae 한용해 CJ Healthcare Immuno-oncology/Autoimmune/Inflammatory
32. hong hyunryung NEW YORK BLOOD CENTER
25 | P a g e 2 0 1 9 K A S B P S p r i n g S y m p o s i u m
Last name First name 한글 이름 Affiliation Group Networking
33. Hong Miyoun Celgene Corp Respiratory/metabolic/cardiovascular/Aging/mental/Neurogenerative
34. Hong Patrick Cellectis Inc. Cell and Gene Therapy/Viral infection/Rare disease
35. Hwang Ji Young 황지영 Torque Therapeutics PK/PD/pre-clinical/Clinical Science:
36. Im Eunju 임은주 Nathan S. Kline Institute/NYU school of Medicine
Respiratory/metabolic/cardiovascular/Aging/mental/Neurogenerative
37. JANG JAYOUNG 장자영 Weil cornell university Cell and Gene Therapy/Viral infection/Rare disease
38. JEONG Heykyeong 정혜경 Temple University Cell and Gene Therapy/Viral infection/Rare disease
39. Jeong Jae Uk 정재욱 GSK
40. Jeong Yu Young 정유영 Rutgers University Respiratory/metabolic/cardiovascular/Aging/mental/Neurogenerative
41. Jo Eui-Cheol 조의철 Mogam Institute for Biomedical Research
Cell and Gene Therapy/Viral infection/Rare disease
42. Jo Hakryul 조 학렬 Agios Pharmaceuticals Cell and Gene Therapy/Viral infection/Rare disease
43. Jo Jay-Hyun 조재현 NIH Immuno-oncology/Autoimmune/Inflammatory
44. Jo JIhye 조지혜 Yale Chemistry Department
45. Ju-Hyun Lim 임주현 Hanmi
46. Jung Hyunkyung 정현경 University of Illinois at Urbana Champaign
PK/PD/pre-clinical/Clinical Science:
47. Kam Emily Northeastern University
48. Kam Yoonseok 감윤석 Agilent Technologies Immuno-oncology/Autoimmune/Inflammatory
49. Kang hyekyung 강혜경 ChemicalEnergy Investment Management
BD/Legal/VC:
50. Kang Min-Jong 강민종 Yale University School of Medicine
51. Kim Boyoung 김보영 Harvard Medical School Cell and Gene Therapy/Viral infection/Rare disease
52. Kim Byungchan 김병찬 Schrodinger Inc Chemistry
53. Kim Dennis Kim Dong Won
Emerald Health Sciences Respiratory/metabolic/cardiovascular/Aging/mental/Neurogenerative
54. Kim Domyoung 김도명 RPI Cell and Gene Therapy/Viral infection/Rare disease
55. Kim Gloria 김보라 University of Pennsylania Cell and Gene Therapy/Viral infection/Rare disease
56. Kim Huen Suk (Crystal)
김현숙 MSKCC Respiratory/metabolic/cardiovascular/Aging/mental/Neurogenerative
57. Kim Hyaeyeong 김혜영 Weill Cornell Medicine Cell and Gene Therapy/Viral infection/Rare disease
58. Kim Hyelim MCPHS University Cell and Gene Therapy/Viral infection/Rare disease
59. Kim Hyun Chung 김현정 KSEA Pharmacy
60. Kim Hyunjin Rutgers University Pharmacy
61. Kim Hyunjin 김현진 CKD Pharmaceuticals Chemistry
62. Kim HyunJun 김현준 MCPHS University Pharmacy
63. Kim Ilhoon 김일훈 GC녹십자 Cell and Gene Therapy/Viral infection/Rare disease
64. Kim Jae-Hun 김재훈 IFF Chemistry
26 | P a g e 2 0 1 9 K A S B P S p r i n g S y m p o s i u m
Last name First name 한글 이름 Affiliation Group Networking
65. Kim Jia 김지아 Weill Cornell Medicine Cell and Gene Therapy/Viral infection/Rare disease
66. Kim Jinhee 김진희 Rutgers New Jersey Medical School
Immuno-oncology/Autoimmune/Inflammatory
67. Kim Jinrang 김진랑 Regeneron Pharmaceuticals
68. Kim John Pierre Fabre Pharmaceuticals, Inc.
BD/Legal/VC:
69. Kim Joohae 김주혜 St. John’s University BD/Legal/VC:
70. Kim Joonyul 김준열 Proximity Biosciences Inc BD/Legal/VC:
71. Kim Juny 김주은 CRScube America BD/Legal/VC:
72. Kim Kevin 김재훈 Wave Life Sciences Cell and Gene Therapy/Viral infection/Rare disease
73. Kim Kyung 김경효 AbbVie
74. Kim Minsu 김민수 VORONOI Inc. Immuno-oncology/Autoimmune/Inflammatory
75. Kim Mi-Sook 김미숙 Takeda PK/PD/pre-clinical/Clinical Science:
76. Kim Nam Cheol 김남철 United States Pharmacopeia Pharmacy
77. Kim Sahee 김사희 RevHealth Pharmacy
78. Kim Sanghyeon 김상현 SMRI Immuno-oncology/Autoimmune/Inflammatory
79. Kim Sarah 김별 St.John’s University Pharmacy
80. Kim Sean 김승빈 Blueprint Medicines PK/PD/pre-clinical/Clinical Science:
81. Kim Seong Kon 김성곤 종근당 Chemistry
82. Kim Seung Wook 김승욱 University of Texas at Austin Chemistry
83. Kim Seungkee 김승기 Ernest Mario School of Pharmacy Pharmacy
84. Kim Soan 김소안 Albany College of Pharmacy and Health Sciences
Pharmacy
85. Kim Sung ki 김성기 MCPHS university BD/Legal/VC:
86. Kim Sung-jun 김성준 the yakup shinmoon
87. Kim Sung-Kwon 김성권 Alexion Pharmaceuticals Immuno-oncology/Autoimmune/Inflammatory
88. Kim Woosook 김우숙 Columbia University Medical Center
Immuno-oncology/Autoimmune/Inflammatory
89. Kim Young Woo 김 영우 Access Bio BD/Legal/VC:
90. Kim Youngsoo 김영수 Ionis Pharmaceuticals Inc. Immuno-oncology/Autoimmune/Inflammatory
91. Kim Youngsun 김영선 Adello Biologics Cell and Gene Therapy/Viral infection/Rare disease
92. Kong Philip 공필립 Yale University PK/PD/pre-clinical/Clinical Science:
93. Koo Jaseok Yale School of Medicine
94. kwon hyuk-kwon 권혁권 1Department of Orthopaedics and Rehabilitation, Yale University School of Medicine
95. KWON ICK CHAN 권익찬 Dana Farber Cancer Institute Immuno-oncology/Autoimmune/Inflammatory
96. Kwon Keon Woo 권건우 University of Pennsylvania Cell and Gene Therapy/Viral infection/Rare disease
97. Kwon Ohbong 권오봉 New York City College of Technology
98. Kwon Se Chang 권세창 Hanmi
27 | P a g e 2 0 1 9 K A S B P S p r i n g S y m p o s i u m
Last name First name 한글 이름 Affiliation Group Networking
99. Laramy Janice 이경미 SK Life Science
100. Lee Boeun 이보은 University of Pennsylvania Respiratory/metabolic/cardiovascular/Aging/mental/Neurogenerative
101. Lee Chang-Sun (Sam)
이창선 Legochem Bio
102. Lee Dong Min (Janet)
이동민 Novocure Pharmacy
103. Lee Dooyoung 이두영 Morphic Therapeutic PK/PD/pre-clinical/Clinical Science:
104. Lee Gwen 이귀인 PRISMS BD/Legal/VC:
105. Lee Hak-Myung 이학명 Shire Cell and Gene Therapy/Viral infection/Rare disease
106. Lee Hyun-Hee 이현회 Merck Immuno-oncology/Autoimmune/Inflammatory
107. LEE INKYU 이인규 Yale medical school Orthoperdics and Rehabilitation
108. Lee Inyoung 이인영 University of Illinois at Chicago (UIC)
BD/Legal/VC:
109. Lee Ji Eun 이지은 MCPHS University Respiratory/metabolic/cardiovascular/Aging/mental/Neurogenerative
110. Lee Kyuhong 이규홍 Korea Institute of Toxicology Respiratory/metabolic/cardiovascular/Aging/mental/Neurogenerative
111. Lee Lauren Young-Mi
이영미 한미약품
112. Lee Saelim 이세림 Orthopaedics&rehabilitation department, Yale medical school
113. Lee SJ 이승주 Orum Therapeutics Immuno-oncology/Autoimmune/Inflammatory
114. Lee So Jeong 이소정 Rutgers University, Ernest Mario School Of Pharmacy
Pharmacy
115. Lee SungKyoung 이성경 University of Pennsylvania and Jubilee Biotech
PK/PD/pre-clinical/Clinical Science:
116. Lee Yong-Hee 이용희 Bridge Biotherapeutics US
117. LEE YOUNKYOUNG
이윤경 NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH
Cell and Gene Therapy/Viral infection/Rare disease
118. Lim Hanjo 임한조 Genentech PK/PD/pre-clinical/Clinical Science:
119. Lim Jihyeon 임지현 Johnson and Johnson Chemistry
120. MIN SANGHYUN 민상현 DGMIF
121. Min Sooweon University of Illinois at Chicago College of Pharmacy
122. Moon Dawn 문다은 Northeastern University Pharmacy
123. Moon JaeHoon 문재훈 (주)녹십자 종합연구소
124. Moon Young-Choon 문영춘 PTC Therapeutics, Inc.
125. NA Seungtaek 나승택 DAEJOONG Investment Co. Immuno-oncology/Autoimmune/Inflammatory
126. Nam Jongmin 남종민 Rutgers University-Camden BD/Legal/VC:
127. Oh Choongseob 오충섭 Celltrion
128. Oh Chris Chigon 오치곤 ENVIGO CRS KOREA BD/Legal/VC:
129. Oh Richard Novo Nordisk Pharmacy
130. Oh Seo Jin 오서진 St. John's University College of Pharmacy
Pharmacy
131. Oh Seung Wook 오승욱 MDimune Inc. Respiratory/metabolic/cardiovascular/Aging/mental/Neurogenerative
28 | P a g e 2 0 1 9 K A S B P S p r i n g S y m p o s i u m
Last name First name 한글 이름 Affiliation Group Networking
132. Oh Younghoon 오영훈 Spark Therapeutics Cell and Gene Therapy/Viral infection/Rare disease
133. Paik Ik-Hyeon 백익현 WAVE Life Sciences, Inc. Chemistry
134. Park Hongsuk 박홍석 Washington University School of Medicine in St. Louis
Respiratory/metabolic/cardiovascular/Aging/mental/Neurogenerative
135. Park Ji Young 박지영 Golden HealthCare Pharmacy PK/PD/pre-clinical/Clinical Science:
136. Park Jonghanne 박종한 LaSante Health Center PK/PD/pre-clinical/Clinical Science:
137. Park Jooman 박주만 University of Massachusetts Medical School
Respiratory/metabolic/cardiovascular/Aging/mental/Neurogenerative
138. Park Joon Seok 박준석 대웅제약 Immuno-oncology/Autoimmune/Inflammatory
139. Park Kwangsu 박광수 School of medicine at Mount Sinai
Chemistry
140. Park Kyo 박기효 GC Pharma (GC녹십자)
141. Park Melody 박나슬 MCPHS University Pharmacy
142. Park Saejeong 박세정 Yale University Respiratory/metabolic/cardiovascular/Aging/mental/Neurogenerative
143. PARK SANGWOOK 박상욱 대원제약 PK/PD/pre-clinical/Clinical Science:
144. Park Soo-Hee 박수희 Novartis Respiratory/metabolic/cardiovascular/Aging/mental/Neurogenerative
145. Park Soyeon 박소연 한미약 품
146. Park Sungyong 박성용 IPON Boston, Inc. BD/Legal/VC:
147. PARK YOOHOI 박유회 Yuhan R&D Institute Immuno-oncology/Autoimmune/Inflammatory
148. Rhee So Hyun 이소현 Rutgers University PK/PD/pre-clinical/Clinical Science:
149. Rhu Hong Yeol 류홍열 Yale University Chemistry
150. RYOO JEPHIL 류제필 Galaxy Bio Inc. Immuno-oncology/Autoimmune/Inflammatory
151. Seo Jiwon 서지원 Northeastern University Pharmacy School
BD/Legal/VC:
152. SHIN HYEON JUN 신현준 Yale School of Medicine
153. Shin Young Eun 신영은 St. John's University Pharmacy
154. Sohn Jung-woo 손정우 ATCC Center for Translational Microbiology
155. SOHN SEIL 손세일 대원제약(주) PK/PD/pre-clinical/Clinical Science:
156. Son Jimin 손지민 St. John's University BD/Legal/VC:
157. Son MinYoung NewYork-Presbyterian Respiratory/metabolic/cardiovascular/Aging/mental/Neurogenerative
158. SON MOONHO 손문호 DGMIF
159. Song Dongweon 송동원 Pfizer
160. Song Mina 송민아 N/A Cell and Gene Therapy/Viral infection/Rare disease
161. Song Saera 송세라 Columbia University Cell and Gene Therapy/Viral infection/Rare disease
162. Song Yvonne Ehwang
송이황 Sanofi Pharmacy
163. Suh K. Stephen 서광선 DiagnoCine Cell and Gene Therapy/Viral infection/Rare disease
164. Suh Sandy Exeltis Pharmacy
165. Sung Kisa 성기사 Icahn School of Medicine at Mount Sinai
Cell and Gene Therapy/Viral infection/Rare disease
29 | P a g e 2 0 1 9 K A S B P S p r i n g S y m p o s i u m
Last name First name 한글 이름 Affiliation Group Networking
166. Sung Moo Je 성무제 Novartis Chemistry
167. UH DONGKYU 어동규 Daewoong Pharmaceuticals BD/Legal/VC:
168. Um Moonkyoung 엄문경 Mintz Levin BD/Legal/VC:
169. woo changjae 우창재 국립암센터 Pharmacy
170. Woo Jungreem 우정림 Thomas Jefferson University Cell and Gene Therapy/Viral infection/Rare disease
171. Yang Hyeon Jeong 양현정 Rutgers University Pharmacy student
Pharmacy
172. Yang Sungjae 양성재 CELLTRION
173. Yang Yerin 양예린 St. John's University Pharmacy
174. Yi Sooji 이수지 Northeastern University Pharmacy
175. Yoo Lang 유랑 Nathan Kline Institute Respiratory/metabolic/cardiovascular/Aging/mental/Neurogenerative
176. Yoon Taewon 윤태원 유한 USA (Boston office) Immuno-oncology/Autoimmune/Inflammatory
177. Yoon Taeyoung 윤태영 Dong-A ST Immuno-oncology/Autoimmune/Inflammatory
Group Networking Last name First name 한글 이름 Affiliation
Ahn Byungyong 안병용 University of Pennsylvania
AN YOUNGTAE 안영태 DGMIF
Cho Jeong Woo 조정우 SK Biopharmaceuticals
Choi Seungkwon 최승권 GC Pharma (GC녹십자)
HAHM Sean 함성원 The Yakup Shinmoon
HAN DAE 한대엽 YALE UNIVERSITY
hong hyunryung NEW YORK BLOOD CENTER
Jeong Jae Uk 정재욱 GSK
Jo JIhye 조지혜 Yale Chemistry Department
Ju-Hyun Lim 임주현 Hanmi
Kam Emily Northeastern University
Kang Min-Jong 강민종 Yale University School of Medicine
Kim Jinrang 김진랑 Regeneron Pharmaceuticals
Kim Kyung 김경효 AbbVie
Kim Sung-jun 김성준 the yakup shinmoon
Koo Jaseok Yale School of Medicine
kwon hyuk-kwon 권혁권 1Department of Orthopaedics and Rehabilitation, Yale University School of Medicine
Kwon Ohbong 권오봉 New York City College of Technology
Kwon Se Chang 권세창 Hanmi
Laramy Janice 이경미 SK Life Science
Lee Chang-Sun (Sam)
이창선 Legochem Bio
LEE INKYU 이인규 Yale medical school Orthoperdics and Rehabilitation
30 | P a g e 2 0 1 9 K A S B P S p r i n g S y m p o s i u m
Group Networking Last name First name 한글 이름 Affiliation
Lee Lauren Young-Mi
이영미 한미약품
Lee Saelim 이세림 Orthopaedics&rehabilitation department, Yale medical school
Lee Yong-Hee 이용희 Bridge Biotherapeutics US
MIN SANGHYUN 민상현 DGMIF
Min Sooweon University of Illinois at Chicago College of Pharmacy
Moon JaeHoon 문재훈 (주)녹십자 종합연구소
Moon Young-Choon 문영춘 PTC Therapeutics, Inc.
Oh Choongseob 오충섭 Celltrion
Park Kyo 박기효 GC Pharma (GC녹십자)
Park Soyeon 박소연 한미약 품
SHIN HYEON JUN 신현준 Yale School of Medicine
Sohn Jung-woo 손정우 ATCC Center for Translational Microbiology
SON MOONHO 손문호 DGMIF
Song Dongweon 송동원 Pfizer
Yang Sungjae 양성재 CELLTRION
BD/Legal/VC: Ahn Sungwoo 안성우 Yuhan USA
BD/Legal/VC: Cho Yong 조용성 YC Consulting
BD/Legal/VC: Choe Yun H. 최윤 Lucas and Mercanti, LLP
BD/Legal/VC: Choi Yongjin 최용진 Regeneron Pharmaceuticals, Inc.
BD/Legal/VC: Kang hyekyung 강혜경 ChemicalEnergy Investment Management
BD/Legal/VC: Kim John Pierre Fabre Pharmaceuticals, Inc.
BD/Legal/VC: Kim Joohae 김주혜 St. John’s University
BD/Legal/VC: Kim Joonyul 김준열 Proximity Biosciences Inc
BD/Legal/VC: Kim Juny 김주은 CRScube America
BD/Legal/VC: Kim Sung ki 김성기 MCPHS university
BD/Legal/VC: Kim Young Woo 김 영우 Access Bio
BD/Legal/VC: Lee Gwen 이귀인 PRISMS
BD/Legal/VC: Lee Inyoung 이인영 University of Illinois at Chicago (UIC)
BD/Legal/VC: Nam Jongmin 남종민 Rutgers University-Camden
BD/Legal/VC: Oh Chris Chigon 오치곤 ENVIGO CRS KOREA
BD/Legal/VC: Park Sungyong 박성용 IPON Boston, Inc.
BD/Legal/VC: Seo Jiwon 서지원 Northeastern University Pharmacy School
BD/Legal/VC: Son Jimin 손지민 St. John's University
BD/Legal/VC: UH DONGKYU 어동규 Daewoong Pharmaceuticals
BD/Legal/VC: Um Moonkyoung 엄문경 Mintz Levin
Cell and Gene Therapy/Viral infection/Rare disease
Cho Woong Hee 조웅희 UT Southwestern Medical Center
Cell and Gene Therapy/Viral infection/Rare disease
Choi Barlgum 최밝음 Alexion Pharmaceuticals
Cell and Gene Therapy/Viral infection/Rare disease
Choi Jeongjoon 최정준 Yale University
31 | P a g e 2 0 1 9 K A S B P S p r i n g S y m p o s i u m
Group Networking Last name First name 한글 이름 Affiliation
Cell and Gene Therapy/Viral infection/Rare disease
Chung HaeWon 정해원 Asimov
Cell and Gene Therapy/Viral infection/Rare disease
Hong Patrick Cellectis Inc.
Cell and Gene Therapy/Viral infection/Rare disease
JANG JAYOUNG 장자영 Weil cornell university
Cell and Gene Therapy/Viral infection/Rare disease
JEONG Heykyeong 정혜경 Temple University
Cell and Gene Therapy/Viral infection/Rare disease
Jo Eui-Cheol 조의철 Mogam Institute for Biomedical Research
Cell and Gene Therapy/Viral infection/Rare disease
Jo Hakryul 조 학렬 Agios Pharmaceuticals
Cell and Gene Therapy/Viral infection/Rare disease
Kim Boyoung 김보영 Harvard Medical School
Cell and Gene Therapy/Viral infection/Rare disease
Kim Domyoung 김도명 RPI
Cell and Gene Therapy/Viral infection/Rare disease
Kim Gloria 김보라 University of Pennsylania
Cell and Gene Therapy/Viral infection/Rare disease
Kim Hyaeyeong 김혜영 Weill Cornell Medicine
Cell and Gene Therapy/Viral infection/Rare disease
Kim Hyelim MCPHS University
Cell and Gene Therapy/Viral infection/Rare disease
Kim Ilhoon 김일훈 GC녹십자
Cell and Gene Therapy/Viral infection/Rare disease
Kim Jia 김지아 Weill Cornell Medicine
Cell and Gene Therapy/Viral infection/Rare disease
Kim Kevin 김재훈 Wave Life Sciences
Cell and Gene Therapy/Viral infection/Rare disease
Kim Youngsun 김영선 Adello Biologics
Cell and Gene Therapy/Viral infection/Rare disease
Kwon Keon Woo 권건우 University of Pennsylvania
Cell and Gene Therapy/Viral infection/Rare disease
Lee Hak-Myung 이학명 Shire
Cell and Gene Therapy/Viral infection/Rare disease
LEE YOUNKYOUNG
이윤경 NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH
Cell and Gene Therapy/Viral infection/Rare disease
Oh Younghoon 오영훈 Spark Therapeutics
Cell and Gene Therapy/Viral infection/Rare disease
Song Mina 송민아 N/A
Cell and Gene Therapy/Viral infection/Rare disease
Song Saera 송세라 Columbia University
Cell and Gene Therapy/Viral infection/Rare disease
Suh K. Stephen Kwangsun Suh
DiagnoCine
Cell and Gene Therapy/Viral infection/Rare disease
Sung Kisa 성기사 Icahn School of Medicine at Mount Sinai
Cell and Gene Therapy/Viral infection/Rare disease
Woo Jungreem 우정림 Thomas Jefferson University
Chemistry Choi Junyong 최준용 Queens College - CUNY
Chemistry Chung Seungwon 정승원 AbbVie
Chemistry Han Wooseok 한우석 Novartis Institutes for BioMedical Research
Chemistry Kim Byungchan 김병찬 Schrodinger Inc
Chemistry Kim Hyunjin 김현진 CKD Pharmaceuticals
Chemistry Kim Jae-Hun 김재훈 IFF
32 | P a g e 2 0 1 9 K A S B P S p r i n g S y m p o s i u m
Group Networking Last name First name 한글 이름 Affiliation
Chemistry Kim Seong Kon 김성곤 종근당
Chemistry Kim Seung Wook 김승욱 University of Texas at Austin
Chemistry Lim Jihyeon 임지현 Johnson and Johnson
Chemistry Paik Ik-Hyeon 백익현 WAVE Life Sciences, Inc.
Chemistry Park Kwangsu 박광수 School of medicine at Mount Sinai
Chemistry Rhu Hong Yeol 류홍열 Yale University
Chemistry Sung Moo Je 성무제 Novartis
Immuno-oncology/Autoimmune/Inflammatory
Ahn Kyonghoon 안경훈 Daewoong pharmaceutical company, Bio-research cencer
Immuno-oncology/Autoimmune/Inflammatory
Chang Kern 장건희 Janssen R&D LLC.
Immuno-oncology/Autoimmune/Inflammatory
Choi Jeea 최지아 Novartis
Immuno-oncology/Autoimmune/Inflammatory
Choo Min-Kyung 추민경 Takeda
Immuno-oncology/Autoimmune/Inflammatory
Han Celine Garam 한가람 BMS (Bristol-Myers Squibb)
Immuno-oncology/Autoimmune/Inflammatory
Han Yong-Hae 한용해 CJ Healthcare
Immuno-oncology/Autoimmune/Inflammatory
Jo Jay-Hyun 조재현 NIH
Immuno-oncology/Autoimmune/Inflammatory
Kam Yoonseok 감윤석 Agilent Technologies
Immuno-oncology/Autoimmune/Inflammatory
Kim Jinhee 김진희 Rutgers New Jersey Medical School
Immuno-oncology/Autoimmune/Inflammatory
Kim Minsu 김민수 VORONOI Inc.
Immuno-oncology/Autoimmune/Inflammatory
Kim Sanghyeon 김상현 SMRI
Immuno-oncology/Autoimmune/Inflammatory
Kim Sung-Kwon 김성권 Alexion Pharmaceuticals
Immuno-oncology/Autoimmune/Inflammatory
Kim Woosook 김우숙 Columbia University Medical Center
Immuno-oncology/Autoimmune/Inflammatory
Kim Youngsoo 김영수 Ionis Pharmaceuticals Inc.
Immuno-oncology/Autoimmune/Inflammatory
KWON ICK CHAN 권익찬 Dana Farber Cancer Institute
Immuno-oncology/Autoimmune/Inflammatory
Lee Hyun-Hee 이현회 Merck
Immuno-oncology/Autoimmune/Inflammatory
Lee SJ 이승주 Orum Therapeutics
Immuno-oncology/Autoimmune/Inflammatory
NA Seungtaek 나승택 DAEJOONG Investment Co.
Immuno-oncology/Autoimmune/Inflammatory
Park Joon Seok 박준석 대웅제약
Immuno-oncology/Autoimmune/Inflammatory
PARK YOOHOI 박유회 Yuhan R&D Institute
Immuno-oncology/Autoimmune/Inflammatory
RYOO JEPHIL 류제필 Galaxy Bio Inc.
Immuno-oncology/Autoimmune/Inflammatory
Yoon Taewon 윤태원 유한 USA (Boston office)
Immuno-oncology/Autoimmune/Inflammatory
Yoon Taeyoung 윤태영 Dong-A ST
Pharmacy Bae Jihyun 배지현 Rutgers University
33 | P a g e 2 0 1 9 K A S B P S p r i n g S y m p o s i u m
Group Networking Last name First name 한글 이름 Affiliation
Pharmacy Chung DaEun 정다은 Rutgers University
Pharmacy Kim Hyun Chung 김현정 KSEA
Pharmacy Kim Hyunjin Rutgers University
Pharmacy Kim HyunJun 김현준 MCPHS University
Pharmacy Kim Nam Cheol 김남철 United States Pharmacopeia
Pharmacy Kim Sahee 김사희 RevHealth
Pharmacy Kim Sarah 김별 St.John’s University
Pharmacy Kim Seungkee 김승기 Ernest Mario School of Pharmacy
Pharmacy Kim Soan 김소안 Albany College of Pharmacy and Health Sciences
Pharmacy Lee Dong Min (Janet)
이동민 Novocure
Pharmacy Lee So Jeong 이소정 Rutgers University, Ernest Mario School Of Pharmacy
Pharmacy Moon Dawn 문다은 Northeastern University
Pharmacy Oh Richard Novo Nordisk
Pharmacy Oh Seo Jin 오서진 St. John's University College of Pharmacy
Pharmacy Park Melody 박나슬 MCPHS University
Pharmacy Shin Young Eun 신영은 St. John's University
Pharmacy Song Yvonne Ehwang
송이황 Sanofi
Pharmacy Suh Sandy Exeltis
Pharmacy woo changjae 우창재 국립암센터
Pharmacy Yang Hyeon Jeong 양현정 Rutgers University Pharmacy student
Pharmacy Yang Yerin 양예린 St. John's University
Pharmacy Yi Sooji 이수지 Northeastern University
PK/PD/pre-clinical/Clinical Science: Chang Rae Sung 장래성 Access Bio, Inc.
PK/PD/pre-clinical/Clinical Science: Cho Sungjoon 조성준 University of Illinois at Chicago
PK/PD/pre-clinical/Clinical Science: Chung Seung Wook 정승욱 Boehringer Ingelheim
PK/PD/pre-clinical/Clinical Science: Hwang Ji Young 황지영 Torque Therapeutics
PK/PD/pre-clinical/Clinical Science: Jung Hyunkyung 정현경 University of Illinois at Urbana Champaign
PK/PD/pre-clinical/Clinical Science: Kim Mi-Sook 김미숙 Takeda
PK/PD/pre-clinical/Clinical Science: Kim Sean 김승빈 Blueprint Medicines
PK/PD/pre-clinical/Clinical Science: Kong Philip 공필립 Yale University
PK/PD/pre-clinical/Clinical Science: Lee Dooyoung 이두영 Morphic Therapeutic
PK/PD/pre-clinical/Clinical Science: Lee SungKyoung 이성경 University of Pennsylvania and Jubilee Biotech
PK/PD/pre-clinical/Clinical Science: Lim Hanjo 임한조 Genentech
PK/PD/pre-clinical/Clinical Science: Park Ji Young JiYoung Park
Golden HealthCare Pharmacy
PK/PD/pre-clinical/Clinical Science: Park Jonghanne 박종한 LaSante Health Center
PK/PD/pre-clinical/Clinical Science: PARK SANGWOOK 박상욱 대원제약
PK/PD/pre-clinical/Clinical Science: Rhee So Hyun 이소현 Rutgers University
PK/PD/pre-clinical/Clinical Science: SOHN SEIL 손세일 대원제약(주)
Respiratory/metabolic/cardiovascular/Aging/mental/Neurogenerative
Aoyagi Kazuko Celerion Inc
34 | P a g e 2 0 1 9 K A S B P S p r i n g S y m p o s i u m
Group Networking Last name First name 한글 이름 Affiliation
Respiratory/metabolic/cardiovascular/Aging/mental/Neurogenerative
Baik Jungeun 백정은 Memorial Sloan Kettering Cancer Center
Respiratory/metabolic/cardiovascular/Aging/mental/Neurogenerative
CHO SUNG YUN 조성윤 Weill Cornell Medicine
Respiratory/metabolic/cardiovascular/Aging/mental/Neurogenerative
Hong Miyoun Celgene Corp
Respiratory/metabolic/cardiovascular/Aging/mental/Neurogenerative
Im Eunju 임은주 Nathan S. Kline Institute/NYU school of Medicine
Respiratory/metabolic/cardiovascular/Aging/mental/Neurogenerative
Jeong Yu Young 정유영 Rutgers University
Respiratory/metabolic/cardiovascular/Aging/mental/Neurogenerative
Kim Dennis Kim Dong Won
Emerald Health Sciences
Respiratory/metabolic/cardiovascular/Aging/mental/Neurogenerative
Kim Huen Suk (Crystal)
김현숙 MSKCC
Respiratory/metabolic/cardiovascular/Aging/mental/Neurogenerative
Lee Boeun 이보은 University of Pennsylvania
Respiratory/metabolic/cardiovascular/Aging/mental/Neurogenerative
Lee Ji Eun 이지은 MCPHS University
Respiratory/metabolic/cardiovascular/Aging/mental/Neurogenerative
Lee Kyuhong 이규홍 Korea Institute of Toxicology
Respiratory/metabolic/cardiovascular/Aging/mental/Neurogenerative
Oh Seung Wook 오승욱 MDimune Inc.
Respiratory/metabolic/cardiovascular/Aging/mental/Neurogenerative
Park Hongsuk 박홍석 Washington University School of Medicine in St. Louis
Respiratory/metabolic/cardiovascular/Aging/mental/Neurogenerative
Park Jooman 박주만 University of Massachusetts Medical School
Respiratory/metabolic/cardiovascular/Aging/mental/Neurogenerative
Park Saejeong 박세정 Yale University
Respiratory/metabolic/cardiovascular/Aging/mental/Neurogenerative
Park Soo-Hee 박수희 Novartis
Respiratory/metabolic/cardiovascular/Aging/mental/Neurogenerative
Son MinYoung NewYork-Presbyterian
Respiratory/metabolic/cardiovascular/Aging/mental/Neurogenerative
Yoo Lang 유랑 Nathan Kline Institute
KASBP Spring Symposium Sponsors