P16081: SYSTEMIC CIRCULATION MODEL

Jacob Zaremski – Lead Engineer

Mallory Lennon – Project Manager

John Ray – Communications Manager

Fabian Perez – Purchasing Coordinator

Robert Kelley – Document Control/EDGE Coordinator

Our goals for this review

Updates from Phase I Review (Background)• Engineering Requirements

• Customer Requirements

• Market Analysis

Functional Decomposition

Concept Development

System Architecture

Engineering Analysis

Risk Assessment

Project Plans

Agenda

10 minutes

5 minutes

10 minutes

5 minutes

15 minutes

5 minutes

2 minutes

Goals

1. Receive feedback

2. Identify obstacles between current state and desired

end goal

3. Clarify feedback

4. Create action plan for each

Project Statement

• Develop a physical model of systemic

circulation

• Provide a teaching tool that will validate

theoretical models from Chapter 5 of Feher

• Measure relevant outputs: pressure and flow

• Interface with P16080 project

Use Scenario

Marketing Potential• Quantitative Human

Physiology: An Introduction by Joseph J. Feher

($119.95 @ RIT B&N)

• Add lab fee $15/student/semester

• Average 70 students/semester

• Covers ability to build new system each semester (if desired)

• Add model as addition to purchasing textbook

• Add lab experiment and computer program as additional costs

1

Customer Requirements (1 of 2)

Customer Requirements (2 of 2)

Engineering Requirements (1 of 2)

Engineering Requirements (2 of 2)

System Architecture

Flow Diagram

Functional Decomposition

Morph Chart (1 of 2)

Morph Chart (2 of 2)

Concept Selection Criteria

Design Concepts

Pugh Chart (1 of 3)

Pugh Chart (2 of 3)

Pugh Chart (3 of 3)

Preliminary Engineering Analysis

• Lumped Parameter Model

• Governing Equations

• Critical Parameters and Ranges

Lumped Parameter Model

Lumped Parameter Model

QcQR

Resistance, RC

Resistance, RA

Resistance, RV

Pressure, PA

Pressure, PC Pressure, PV

Cardiac OutputVenous Return

v

P16081 Pump

Arterial Compliance,

CA

VenousCompliance,

CV

CapillaryCompliance,

CC

Subsystem Model

Measured

Defined

2

Governing Equations: Flow

Governing Equations: Resistance• Poiseuille’s Law

Governing Equations: Compliance

Tygon Tubing- has been shown to have physiologically relevant compliance- higher wall hardness for arterial, softer for venous

7

Fluid Capacitors

Spring piston Air chamber acts as spring

Spring piston

(Woodruff et al, 1997)

For A = 10 in2:

PCylindrical Tank

Compliance Range: 1-200 mL/mmHg

Rectangular Prism TanksPP

CArterial

CVenousCompliance Range: 1-200 mL/mmHg

Concept Risks

Technical Risks

Resource Risks

Safety Risks

Environmental Risks

Theoretical Risk Assessment

Project Plans Phase 2

Project Plan Phase 3

Next Steps

• Engineering Analysis

• Budget Feasibility

• Iterate Pugh Chart

• Collaboration with P16080

• PASCO sensors

Concerns1. Lacking sufficient background knowledge to

make supported decisions about system

components

2. Accurately modeling textbook models and

what precision we will be able to achieve

3. Creating the software interface to run system

and/or record desired outputs

4. Possible sources of error that are neglected in

calculations

Acknowledgements

RIT Faculty• Dr. Jennifer Bailey• Dr. Steven Day

U of R Faculty• Dr. Schwartz• Dr. Doran Mix

Guide• Gerald Garavuso

Sources1. http://www.amazon.com/Quantitative-Human-Physiology-Introduction-Engineering/dp/0123821630

2. Feher, Joseph J. Quantitative Human Physiology: An Introduction. Amsterdam: Elsevier/Academic,

2012. Print.

3. F. M. Donovan. Design of a Hydraulic Analog of the Circulatory System for Evaluating Artificial

Hearts, Biomaterials, Medical Devices, and Artificial Organs, 1975, 3:4, 439-449.

4. https://www.google.com/search?

q=needle+valve&espv=2&biw=1149&bih=659&source=lnms&tbm=isch&sa=X&ved=0CAYQ_AUoAW

oVChMIjIOY0-ieyAIVCqYeCh2pJwgr#imgrc=WwAmF7IltMl6-M%3A

5. http://www.terrybookers.co.uk/35mm-gate-valve-2226-p.asp

6. http://www.hassmfg.com/search.pl/1213638750-2927?keyword=1165

7. Varble N, et al. In vitro hemodynamic model of the arm arteriovenous circulation to study

hemodynamics of native arteriovenous fistula and the distal revascularization and interval ligation

procedure, Journal of Vascular Surgery, 2013, 59:5, 1410-1417.

8. Linearization and nonlinear fluid elements - Dartmouth College

http://www.dartmouth.edu/~sullivan/22files/linearization_and_fluid.pdf

9. Woodruff, Stewart J., Keith M. Sharp, and George M. Pantalos. "Compact Compliance Chamber

Design for the Study of Cardiac Performance in Microgravity." ASAIO Journal (1997): 316-20. Web.

30 Sept. 2015.

ADDITIONAL SLIDES

Customer Requirements Mapping (1 of 2)

Customer Requirements Mapping (2 of 2)