overwhelming fungal infection in a toll deficient background
DESCRIPTION
Overwhelming fungal infection in a Toll deficient background. Leucine rich domains. Toll. TIR domain. NF- k B. NF- k B. Comparison of structures of CD14, Toll and IL-1R. Leucine rich domains. Ig-like domains. IL-1R. CD14. GPI anchor. Cell membrane. TIR domain. - PowerPoint PPT PresentationTRANSCRIPT
Overwhelming fungal infection in a Toll Overwhelming fungal infection in a Toll deficient backgrounddeficient background
Comparison of structures of CD14, Toll and IL-1R
IL-1RIL-1R
TIRTIRdomaindomain
Ig-like Ig-like domainsdomainsCD14CD14
Leucine Leucine rich rich domainsdomains
GPI anchorGPI anchor CellCellmembranemembrane
NF-NF-BB
TollToll
TIRTIRdomaindomain
Leucine Leucine rich rich domainsdomains
NF-NF-BB
Nature, Vol 388, 24 july 1997, 394-397Nature, Vol 388, 24 july 1997, 394-397
Bruce BeutlerBruce Beutler
1
PG, LPLP
2 3 4 5 6 7 8 9 10
dsRNALPS
Flagellin
Zym, LP
ssRNA IMQ IMQ CpG
Toll-like receptors
Complexe ternaire :
1 homodimères + ARNdb
Permet le chevauchement des TIR engageant la signalisation.
Modèle proposéModèle proposé
Parallels between IL-1 and Spz functions
TollToll
MicrobialMicrobial inducersinducers
MammalsMammalsNF-NF-BB
IL-1RIL-1R
DefensinDefensin
IL-1IL-1
IL-1IL-1NF-NF-BB
TLRTLR
ProSpzProSpz
SpaetzleSpaetzle
DrosophilaDrosophila
NF-NF-BB
DrosomycinDrosomycin
PGRP-SAPGRP-SA GNBP-1GNBP-1
Sang
Mannose Rec. (MR, Endo180, DEC205, PLA2R)C-typeLectins
Others(LRR, CARD,…)
Ig-SF
TLR
h LIR (ILT)m PIR
NCRTREMhKIR
NKRP-1
mLY49
NKG2D
DC-SIGN receptorsDectin-2 (NCCL)Langerin
BDCA-2 (DLEC)
NOD moleculesTLR