other immune condtions hiv and aids lupus fibromyalgia hiv and aids lupus fibromyalgia
TRANSCRIPT
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OTHER IMMUNE CONDTIONSOTHER IMMUNE CONDTIONS
• HIV and AIDS
• LUPUS
• FIBROMYALGIA
• HIV and AIDS
• LUPUS
• FIBROMYALGIA
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HUMAN IMMUNODEFICIENCY
VIRUSand
AQUIRED IMMUNODEFICIENCY
SYNDROME
HUMAN IMMUNODEFICIENCY
VIRUSand
AQUIRED IMMUNODEFICIENCY
SYNDROME
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AIDSAIDS1. Immunodeficiency
disorder caused by a virus that destroys T-Cells.
2. The HIV Virus is harbored in the macrophage and Helper T-Cells.
3. The DNA of the virus directs the cells to create new viruses.
1. Immunodeficiency disorder caused by a virus that destroys T-Cells.
2. The HIV Virus is harbored in the macrophage and Helper T-Cells.
3. The DNA of the virus directs the cells to create new viruses.
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CELLS OF THE IMMUNE SYSTEM
CELLS OF THE IMMUNE SYSTEM
Leukocytes
Granulocytes Monocytes Lymphocytes
Neutrophil Eosinophil Basophil T-CELL B-CELL LGL/NK
HELPER & INFLAMMATORY
CYTOTOXIC T
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CELLS OF THE IMMUNE SYSTEM
CELLS OF THE IMMUNE SYSTEM
Leukocytes
Granulocytes Monocytes Lymphocytes
Neutrophil Eosinophil Basophil T-CELL B-CELL LGL/NK
HELPER & INFLAMMATORY
CYTOTOXIC T
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ADAPTIVE IMMUNITYADAPTIVE IMMUNITY
• Cytotoxic T-Cells
• Specific Antigens
• Natural Killer Cells
• Any Antigen
• Cytotoxic T-Cells
• Specific Antigens
• Natural Killer Cells
• Any Antigen
• Kills on Contact
• Releasing Granules
• Kills on Contact
• Releasing Granules
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INFECTION• Bad Flu-like
• Several weeks
INFECTION• Bad Flu-like
• Several weeks
ASYMPTOMATIC
• 10 YRS
ASYMPTOMATIC
• 10 YRS
CLINICAL
AIDS• Infection of an
opportunistic organism, not normally infectious
CLINICAL
AIDS• Infection of an
opportunistic organism, not normally infectious
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EXERCISE CONCERNS in HIV and AIDS
EXERCISE CONCERNS in HIV and AIDS
• DECONDITIONING
• MUSCLE WASTING
• LIPODYSTROPHY
• DECONDITIONING
• MUSCLE WASTING
• LIPODYSTROPHY
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DECONDITIONINGDECONDITIONING
Deleterious effects of bed restDeleterious effects of bed rest• Cardiovascular • Skeletal muscle• Bone and calcium metabolism
• Cardiovascular • Skeletal muscle• Bone and calcium metabolism
• Metabolic and endocrine • Psychosocial
• Metabolic and endocrine • Psychosocial
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WASTINGWASTING
• 5% Loss in Body Weight increases Mortality
• Loss is directly related to lack of modern AIDS treatment
• 5% Loss in Body Weight increases Mortality
• Loss is directly related to lack of modern AIDS treatment
• Decreased Strength
• Decreased Muscle Mass
• Decreased Strength
• Decreased Muscle Mass
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LIPODYSTROPHYLIPODYSTROPHY
• Loss of subcutaneous fat
• Arms• Legs• Face
• Increase in visceral abdominal fat
• Loss of subcutaneous fat
• Arms• Legs• Face
• Increase in visceral abdominal fat
Fat Redistribution SyndromeFat Redistribution Syndrome
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LIPODYSTROPHYLIPODYSTROPHY
• Insulin Resistance
• Elevated Glucose
• Decreased HDL
• Upper Body Obesity• Cardiovascular Disease• Stroke• Diabetes
• Insulin Resistance
• Elevated Glucose
• Decreased HDL
• Upper Body Obesity• Cardiovascular Disease• Stroke• Diabetes
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EXERCISE EFFECTIVENESSEXERCISE EFFECTIVENESS
• Improve Physical Work Capacity
• Improve Mood
• Improve Immune Function
• Decrease Chronic Disease Incidence
• Increase Muscle Strength
• Increase Muscle Mass
• Improve Physical Work Capacity
• Improve Mood
• Improve Immune Function
• Decrease Chronic Disease Incidence
• Increase Muscle Strength
• Increase Muscle Mass
Stringer WW., et al Med Sci Sports Exerc 30:11-16, 1998.
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Stringer WW., et al Med Sci Sports Exerc 30:11-16, 1998.
CONTROL• Maintain current level of activity
CONTROL• Maintain current level of activity
MODERATE INTENSITY• 60 min
• 3/wk
• 80% of Lactate Threshold
MODERATE INTENSITY• 60 min
• 3/wk
• 80% of Lactate Threshold
HEAVY INTENSITY• 3/wk
• 30-40 min
• 50% of VO2max – Lactate Threshold
HEAVY INTENSITY• 3/wk
• 30-40 min
• 50% of VO2max – Lactate Threshold
Cycle Ergometry
Total Amount of Work
Moderate = Heavy
6 weeks
Cycle Ergometry
Total Amount of Work
Moderate = Heavy
6 weeks
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Stringer WW., et al Med Sci Sports Exerc 30:11-16, 1998.
0
100
200
300
400
500
600
Control Moderate Heavy
Pre
Post
SKIN REACTIVITY TESTSA
rea
(m
m2)
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Stringer WW., et al Med Sci Sports Exerc 30:11-16, 1998.
0
10000
20000
30000
40000
50000
60000
Control Moderate Heavy
Pre
Post
HIV VIRAL REPLICATIONC
op
ies
/mL
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Stringer WW., et al Med Sci Sports Exerc 30:11-16, 1998.
QUALITY OF LIFEQUALITY OF LIFE1. How would you rate the quality of your life now?
2. How much longer do you want to live
3. How much longer do you think you will live?
4. Compared to one year ago, how much does your health limit your daily activities? (1=none; 5 = Very limited)
5. I look forward to the future with hope. (1=agree; 5 = disagree)
6. Overall, how would your rate your quality of life? (0=worst; 10 = best).
7. Which best describes how your feel about our life as a whole? (1=terrible; 7=delighted)
1. How would you rate the quality of your life now?
2. How much longer do you want to live
3. How much longer do you think you will live?
4. Compared to one year ago, how much does your health limit your daily activities? (1=none; 5 = Very limited)
5. I look forward to the future with hope. (1=agree; 5 = disagree)
6. Overall, how would your rate your quality of life? (0=worst; 10 = best).
7. Which best describes how your feel about our life as a whole? (1=terrible; 7=delighted)
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Stringer WW., et al Med Sci Sports Exerc 30:11-16, 1998.
-0.8
-0.6
-0.4
-0.2
0
0.2
0.4
0.6
0.8
1 2 3 4 5 6 7
Control
Moderate
Heavy
QUALITY OF LIFEQUALITY OF LIFE
NS
Cha
nge
in S
core
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OTHER INTERVENTION STUDIES
• CD4 COUNTS INCREASED IN THOSE pts WHO ADHERED
• CD4 COUNTS INCREASED IN THOSE pts WHO ADHERED
MacArthur, RD et al Med Sci Sports Exerc 25:684-688, 1993
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PHARAMCOLOGYPHARAMCOLOGYHIGHLY ACTIVE ANTIRETROVIRAL THERAPY
HAART
HIGHLY ACTIVE ANTIRETROVIRAL THERAPY
HAART
• 2-5 Meds
• 1-4 doses/day
• Eating & Drinking restrictions with 1-2 hrs of taking meds
• 2-5 Meds
• 1-4 doses/day
• Eating & Drinking restrictions with 1-2 hrs of taking meds
• Nucleoside Reverse-Transcriptase Inhibitors (NRTI)
• Nonnucleoside Reverse-Trancriptase Inhibitors (NNRTI)
• Protease Inhibitors
• Nucleoside Reverse-Transcriptase Inhibitors (NRTI)
• Nonnucleoside Reverse-Trancriptase Inhibitors (NNRTI)
• Protease Inhibitors
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PHARAMCOLOGYPHARAMCOLOGY
ANABOLIC STERIODSANABOLIC STERIODS
• Nandrolone decanoate
• Oxandrolone
0
1
2
3
4
5
6
7
ND OX
Control
Exercise
Incr
ea
se in
Le
an
Mas
s (k
g)
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EXERCISE TESTINGEXERCISE TESTING
• BODY COMPOSITION• Lean Body Mass• Body Fat Distribution• Skinfold thickness at each site
• FUNCTIONAL ASSESSMENT• Cardiovascular Endurance
• 6 min walk• Stress Testing
• Muscle Strength• Flexibility
• BODY COMPOSITION• Lean Body Mass• Body Fat Distribution• Skinfold thickness at each site
• FUNCTIONAL ASSESSMENT• Cardiovascular Endurance
• 6 min walk• Stress Testing
• Muscle Strength• Flexibility
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EXERCISE PRESCRIPTIONEXERCISE PRESCRIPTION
GOALS:
1. Improve Physical Work Capacity
2. Increase Muscle Mass
3. Increase Muscle Strength
4. Counteract lipodystrophy
5. Improve Immune Function
GOALS:
1. Improve Physical Work Capacity
2. Increase Muscle Mass
3. Increase Muscle Strength
4. Counteract lipodystrophy
5. Improve Immune Function
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EXERCISE PRESCRIPTIONEXERCISE PRESCRIPTION
ENDURANCE STRENGTH
MODE CV Resistance
FREQUENCY 3/wk 3/wk
DURATION 15-25 min 45 min
INTENSITY 65-85% 60-80% RM
ENDURANCE STRENGTH
MODE CV Resistance
FREQUENCY 3/wk 3/wk
DURATION 15-25 min 45 min
INTENSITY 65-85% 60-80% RM
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• Intercurrent Illness• Decrease Intensity• Discontinue
• Fever >100o
• Acute Symptoms• Nausea• Vomiting• Uncontrolled Diarrhea• Dehydration
• Injury (wasting)
• Intercurrent Illness• Decrease Intensity• Discontinue
• Fever >100o
• Acute Symptoms• Nausea• Vomiting• Uncontrolled Diarrhea• Dehydration
• Injury (wasting)
PRECAUTIONSPRECAUTIONS
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LUPUSLUPUS
LUPUS ERYTHEMATOSUS
• Chronic Autoimmune Disease
• Produces Antibodies to Fight own Tissues
LUPUS ERYTHEMATOSUS
• Chronic Autoimmune Disease
• Produces Antibodies to Fight own Tissues
INCIDENCE:• 1.4 – 1.5 Million
• 16,000 / year
• 90% Women
• 15-45 years old
• 2-3x in Minorities
INCIDENCE:• 1.4 – 1.5 Million
• 16,000 / year
• 90% Women
• 15-45 years old
• 2-3x in Minorities
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TYPES OF LUPUSTYPES OF LUPUSDISCOID• Affects the Skin
• Rash• Abnormal Skin Biopsy
• Can evolve to Systemic in 10% of cases
DISCOID• Affects the Skin
• Rash• Abnormal Skin Biopsy
• Can evolve to Systemic in 10% of cases
SYSTEMIC
• Any Organ of the Body
• Predominantly Skin & Joints
• Heart, Lungs, Kidneys, Blood
SYSTEMIC
• Any Organ of the Body
• Predominantly Skin & Joints
• Heart, Lungs, Kidneys, Blood
DRUG-INDUCED• Only 4% who take
• Hydralazine
• Procainamide
DRUG-INDUCED• Only 4% who take
• Hydralazine
• Procainamide
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Sx:• Arthraligia (achy joints) 95%• Fever >100o 90%• Arthritis (swollen joints) 90%• Prolonged or Extreme Fatigue 81%• Skin Rashes 74%• Anemia 71%• Kidney Involvement 50%• Butterfly Rash on cheeks/nose 42%• Sun or Light Sensitivity 30%• Abnormal blood clotting 20%• Raynaud’s Phenomenon 17%• Seizures 15%• Mouth or Nose Ulcers 12%
Sx:• Arthraligia (achy joints) 95%• Fever >100o 90%• Arthritis (swollen joints) 90%• Prolonged or Extreme Fatigue 81%• Skin Rashes 74%• Anemia 71%• Kidney Involvement 50%• Butterfly Rash on cheeks/nose 42%• Sun or Light Sensitivity 30%• Abnormal blood clotting 20%• Raynaud’s Phenomenon 17%• Seizures 15%• Mouth or Nose Ulcers 12%
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• Susceptible Genes
• Environmental Factors• Infectious Agents• Meds
• Anticonvulsants
• Penicillins• Estrogen Therapy
• Excessive Ultraviolet Light• Physical Trauma• Emotional Stress
• Susceptible Genes
• Environmental Factors• Infectious Agents• Meds
• Anticonvulsants
• Penicillins• Estrogen Therapy
• Excessive Ultraviolet Light• Physical Trauma• Emotional Stress
ETIOLOGY
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DIAGNOSIS• Medical History• Physical Examination• Blood Tests
DIAGNOSIS• Medical History• Physical Examination• Blood Tests
RHEUMATOLOGIST must rule out• Chronic Fatigue Syndrome
• Mononucleosis
RHEUMATOLOGIST must rule out• Chronic Fatigue Syndrome
• Mononucleosis
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POSITIVE:• Butterfly Rash
• Sun Sensitivity
• Kidney Disorder
• Blood Abnormalities
• +4/11 other criteria
POSITIVE:• Butterfly Rash
• Sun Sensitivity
• Kidney Disorder
• Blood Abnormalities
• +4/11 other criteria
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THE ELEVEN CRITERIA• Malar Rash Cheeks
• Discoid Rash Red Raised Patches
• Photosensitivity
• Oral Ulcers Nose or mouth
• Arthritis Nonerosive >2 peripheral joints
• Serositis Inflamation of lining of lung or heart
• Renal Disorder Excessive protein in urine
• Neurologic Disorder Seizures and/or psychosis
THE ELEVEN CRITERIA• Malar Rash Cheeks
• Discoid Rash Red Raised Patches
• Photosensitivity
• Oral Ulcers Nose or mouth
• Arthritis Nonerosive >2 peripheral joints
• Serositis Inflamation of lining of lung or heart
• Renal Disorder Excessive protein in urine
• Neurologic Disorder Seizures and/or psychosis
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• Hematologic Disorder Anemia or Leukopenia or lymphopenia or thrombocytopenia
• Antinuclear Antibody + antibodies
• Immunologic Disorder + anti-DNA test + anti-SM test false +syphilis test + antiphospholipid antibody
• Hematologic Disorder Anemia or Leukopenia or lymphopenia or thrombocytopenia
• Antinuclear Antibody + antibodies
• Immunologic Disorder + anti-DNA test + anti-SM test false +syphilis test + antiphospholipid antibody
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TREATMENT• Medications
• Aspirin
• Non-Steroidal Anti-Inflammatory (NSAIDs)
• Acetaminophen (tylenol)
• Antimalarials
• Corticosteroids
• Anticoalgulants
• Avoid Sunlight
• Eat Healthy Diet• Exercise• Minimize Stress• Bone Marrow Transplant (experimental)
TREATMENT• Medications
• Aspirin
• Non-Steroidal Anti-Inflammatory (NSAIDs)
• Acetaminophen (tylenol)
• Antimalarials
• Corticosteroids
• Anticoalgulants
• Avoid Sunlight
• Eat Healthy Diet• Exercise• Minimize Stress• Bone Marrow Transplant (experimental)
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FIBROMYALGIAFIBROMYALGIA• Pain in Muscles and Joints
• Poor Sleep
• Headaches
• Stiffness
• Muscle Aches
• Sensitivity to
• Bright Light• Loud Noise• Meds
• Fatigue
• Pain in Muscles and Joints
• Poor Sleep
• Headaches
• Stiffness
• Muscle Aches
• Sensitivity to
• Bright Light• Loud Noise• Meds
• Fatigue
• 5% of Population
• More common in Women
• Women of Child Bearing Ages
• 5% of Population
• More common in Women
• Women of Child Bearing Ages
Mostly a
ssocia
ted
with R
heumatic
Disease
s
Mostly a
ssocia
ted
with R
heumatic
Disease
s
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CLINICAL FEATURESCLINICAL FEATURES
• 90-100%
• Generalized Pain
• Fatigue
• Stiffness
• Morning Fatigue
• 90-100%
• Generalized Pain
• Fatigue
• Stiffness
• Morning Fatigue
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• 70-90%• Post-exertional malaise• Sleep disturbances• Morning stiffness• Headaches• Tenderness• Swollen Feeling in tissues• Numbness & tingling• Cognitive Impairment• Dizziness• Sensitivity to Noise• Sensitivity to Smell & Stress• Menstrual cramping• Dry mouth
• 70-90%• Post-exertional malaise• Sleep disturbances• Morning stiffness• Headaches• Tenderness• Swollen Feeling in tissues• Numbness & tingling• Cognitive Impairment• Dizziness• Sensitivity to Noise• Sensitivity to Smell & Stress• Menstrual cramping• Dry mouth
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• 50-70%
• Irritable bowel syndrome
• Blurred Vision
• Mood Swings
• Heart Palpatations
• Cold Extremities
• Feverous feeling
• Allergies
• 50-70%
• Irritable bowel syndrome
• Blurred Vision
• Mood Swings
• Heart Palpatations
• Cold Extremities
• Feverous feeling
• Allergies
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• 15-50%
• Restless legs
• Muscle twitches
• Itchy skin
• Hearing disturbances
• Night sweats
• Migraines
• Breathing problems
• Skin rashes
• TMJ dysfunction
• Chemical sensitivities
• 15-50%
• Restless legs
• Muscle twitches
• Itchy skin
• Hearing disturbances
• Night sweats
• Migraines
• Breathing problems
• Skin rashes
• TMJ dysfunction
• Chemical sensitivities
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• Below 15%
• Major depression
• Below 15%
• Major depression
CLINICAL FEATURESCLINICAL FEATURES
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DIAGNOSISDIAGNOSIS
11/18 + POINTS11/18 + POINTS
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TREATMENTTREATMENT
• Medications• Sleep Meds• Seritonin• NSIADs
• Exercise
• Relaxation Techniques
• Educational Programs
• Diet
• Medications• Sleep Meds• Seritonin• NSIADs
• Exercise
• Relaxation Techniques
• Educational Programs
• Diet
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EXERCISEEXERCISE
MODE Walking, Jogging, Cycling
Swimming, Flexibility, ROM
FREQUENCY 4/wk
DURATION up to 60 min
INTENSITY Moderate
MODE Walking, Jogging, Cycling
Swimming, Flexibility, ROM
FREQUENCY 4/wk
DURATION up to 60 min
INTENSITY Moderate
Exercise in the afternoon or early eveningExercise in the afternoon or early evening
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