"ortho" approaches to correcting sleep disruption

8/3/2019 "Ortho" Approaches to Correcting Sleep Disruption

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Bradford S. Weeks, M.D.The Weeks Clinic

forCorrective

Medicine and [email protected] www.weeksmd.com
mailto:[email protected]://www.weeksmd.com/http://www.weeksmd.com/mailto:[email protected]


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Ortho ApproachesTo Correcting

Sleep Disruption(and thereby to living

Happily Ever After)


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What I wantyou to take homefrom this lecture


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1) Understand the nature andtherewith,the importance ofa good nights sleep(without putting you to sleep!)


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2) Contrast:eyes closed, amnesticand

horizontal for 8 hoursvs.therapeutic, deep and

regenerative sleep


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3) Understand thesignificance ofsleep architectureand its changesassociated with

various sleep disorders;


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4) Appreciate the role ofdeep, slow wave orregenerative sleep;

(life giving, anti-aging)


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5) Appreciate the epidemicand cost of sleep disorders;($14 billion in cost)


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6) Considerthe relativebenefits and limitations ofcurrent therapiesfor sleep disruption;(they are unsatisfactory)


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7) Consider optimal orthoor corrective treatmentsforsleep disorders;(they are superior)


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8) Encourage pro-active,empowered attitudes andbehaviors on the part ofcare-givers and patients towardthe diagnosis and treatment ofsleep disturbances.


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SCOPE OF THESLEEP PROBLEM


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American patients#1 chief concernis

FATIGUE


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Communication with patientsregarding sleep must be encouraged

3 in 5 adults claim they have never been asked by adoctorin their entire lifetimehow well they sleep 4 in 5 adults have never initiated a discussion aboutsleep problems with their doctor Sleep composition must be addressed in the patient-doctor conversation to direct effective treatment


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ASLEEP AT THE WHEEL- 100,000 crashes each year are caused byfatigued drivers- 55% of drowsy driving crashes are caused bydrivers < 25 years old- Being awake for 18 hours is equal to ablood alcohol concentration of 0.08%, whichis legally drunk and leaves you at equal riskfor a crash


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Mortality:Estimates:42,000 deaths/year frompeople falling asleep at thewheel; (breaking news:Ambien-related

sleep driving)


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Iatrogenic DeathsHospital Adverse Rxn - 106,000Deaths Medical Error - 98,000Deaths Bedsores - 115,000Deaths Infection - 88,000Deaths Malnutrition - 108,800


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Iatrogenic DeathsOutpatient Adverse Rxn 199,000Unnecessary Procedures 37,136Surgery-Related 32,000Total Annual Deathsby Modern Medicine 783,936


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Total Number of Deaths due tovitamins too few to countminerals too few to countamino acids same storyessential fatty acids dittoherbs you guessed it!


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IATROGENIC INSOMNIA(MEDICATIONS TO BEWARE OF)

colds and allergieshigh blood pressureheart diseasethyroid diseasebirth controlasthmapain medicationsdepression (especially SSRI )


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One half of Americas adults say theyfrequently experience at least onesymptom of insomnia.11% use alcohol as a sleep aid9% use OTC pills as sleep aid


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The Sleep Industryin 2006


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Direct costs include dollars spenton insomnia treatments,healthcare services, hospital andnursing home care.Direct costs of insomnia is nearly$14 billion (ANNUAL)!


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Audio tapes


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Corporate Travel Safety


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NYC MetroNapsArshad Chowdhury CEO founder(in the Empire State Building)$65/month for one20 minute nap a day


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-


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-
http://images.google.com/imgres?imgurl=http://www.metronaps.com/images/200%2520dpi%2520No%2520Visor.jpg&imgrefurl=http://www.livejournal.com/~angelinger/&h=700&w=891&sz=62&tbnid=8wPYM1OKOp9BJM:&tbnh=113&tbnw=145&hl=en&start=1&prev=/images%3Fq%3Dmetronaps%26imgsz%3Dxxlarge%26svnum%3D10%26hl%3Den%26lr%3D%26sa%3DG


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In the future, people will understandthat naps are a healthy benefit and not asign of being lazy. Naps are one of thetop ten trends for 1996.

Gerald Celente, Director, TrendsResearch Institure Rheinbeck, NY


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The myth of Edison's 4 to 6 hoursof sleep a day was dispelled after hisdeath by the report of his laboratorystaff who clocked his naps and foundthat he slept at least 8 hours in thetwenty-four.

Richard A. Kern


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The Restorative Effect of Naps onPerceptual DeteriorationSara C. Mednick,Ph.D.Department of Psychology,Harvard University, Publishedonline: 28 May 2002,


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-


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-


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WHAT IS SLEEP?


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Portion of theaverage life spent

sleeping = 22 years


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Sleep is adynamic processthat is characterized byperiodic changes in

electrophysiologic activity.


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These electrophysiologic changes,which are used to mark the stateand depth of sleep, are associatedwith periodic, short-term variations

in hormonal levels.


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Stage 1Light sleep; between being awake andentering sleep,

Stage 2Onset of sleep; becoming disengagedwith the environment; breathing andheart rate are regular and bodytemperature goes down


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Stage 3 & 4Delta wavesDeep and restorative sleep;blood pressure drops;breathing slower;energy regainedhormones growth and development

(Sleep: the poor mans HGH!)


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REM: 25% of nightFirst occurs about 90 minutes afterfalling asleep and increases over laterpart of night; necessary for providingenergy to brain and body; brain isactive and dreams occur as eyes dartback and forth;


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- bodies become immobile andrelaxed; skeletal muscles relax; penileand clitoral engorgement; breathingand heart rate may become irregular;important to daytime performanceand may contribute to memoryconsolidation.


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A GOOD NIGHTS SLEEP- NREM: 75% of night- REM: 24% of night- Awake: 1% of night


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Sleep is adynamic processthat is characterized byperiodic changes in

electrophysiologic activity.


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IMPORTANCEOF SLEEP


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Sleep is theonly medicinethat gives ease.Sophocles Philoctetes


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We term sleep a death;and yet it is waking that kills us,and destroys those spiritsthat are the house of life.

Thomas Browne, 1643


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Benefits of good sleep:-Regeneration : waxing the candle after burning itat both ends during the busy dayAnabolic hormonal modulation: surges ofmelatonin, HGH, testosterone and lower levels ofcortisol.- Lose weight while you sleep!


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From Yang Jizhou, The Great Compendium ofAcupuncture and Moxibustion ca. 1590:

When a person sleeps, the namelessfire within grows dim in order to

revitalize.


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What is agood nightssleep?


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Question for patient:Are you refreshedin the morning?


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RE-generatedRE-vitalizedRE-chargedRE-couperated


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SLEEP AND DISEASEA COMPLEX

RELATIONSHIP


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Almost any chronic medicalcondition can produceinsomnia

andInsomnia can produce almostany chronic or acutemedical condition.


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2003 SLEEP POLLOFINDIVIDUALS OVER AGE 55ANDREPORTED SLEEP PROBLEM 77% Frequent Pain 76% Treated For Heart Disease 71% Hypertension 80% Over 4 Medical Conditions

National Sleep Foundation 2003


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Fibromylagia isfundamentally a sleepdisorder.


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Disturbed sleep does impactALL psychiatric illness.

ManiaMajor depressive disorderGeneralized anxiety disorder (GAD)Obsessive Compulsive Disorder


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Almost any chronic medicalcondition can produceinsomnia

andInsomnia can produce almostany chronic or acutemedical condition.


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Types ofSleep Disorder


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Secondary

Movementdisorders

Sleep DisordersDyssomnias Parasomnias

Insomnias

Hypersomnia

NarcolepsyBreathingdisorders

Nightfrights

Bedwetting Nocturnaleating

disorder

REMbehaviordisorder

Chronic Transient Apneas Other Restlesslegs

syndrome

Periodiclimb

movementdisorder

Sleep

terrors

Nightmares

Somnambulism/somniloquence

Circadian rhythm Psychophysiologic insomnia Sleep state misperception

Comorbid disease Pain Medications

Obstructive Central

Ondines

curse

Other sleep disorders Substance abuse Other

Idiopathic insomnia Poor sleep hygiene

Primary

American Sleep Disorders Association. The International Classification of Sleep Disorders, Revised:Diagnostic and Coding Manual. Rochester, Minn: American Sleep Disorders Association; 2000.


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INSOMNIAis not a diagnosis.


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It should be thought of as aconstitutional symptom, not unlikepain, fever, or weight loss, requiringidentification of an underlying causebefore a meaningful diagnosis and atreatment plan are established.


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Why?(Ill give you one

guess)


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Snoring is not alaughing matter.Snoring is choking.


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SNORING AND HEADACHE260 Headache Days / Year in 206 SnorersVs

24 Headache Days / Year in 507 non-snorers


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Trouble Falling Asleep(TFA)


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Heavenly Morpheus,in vain do you wave the poppies;My eye will remain awake,if Amor will not close it.

Johann W olfgang von Goethe,


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OTHER CAUSES OF SD-Perimenopause - 42% incidence-Neurochemical imbalances( hypocretin/orexin, serotonin,

dopamine, melatonin)-Nervous Bladder / BPH-Auto-immune insult to the CNS-Pain (acute and or chronic)


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Nocturnal Hypoglycemia


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Sleep and Age

Hobson. Sleep and Dreaming. In: Fundamental Neuroscience. 1999.Roffwarg et al. Science. 1996;152:604.

24

0

8

16

-1 0 1 10 20 100

Conception Birth

Age (y)

Death

Hoursin

day

NREM sleep

Awake

REM sleep


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It is known that breast-fed babieshave better sleep patterns and abetter entrained sleep/wake cyclethan formula, bottle-fed babies.


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The circadian rhythm of tryptophan in breastmilk affects the rhythms of 6-sulfatoxy-melatonin and sleep in newborn.Neuro. Endocrinol Lett. 2005 Dec 28;26(6):657-661 Cubero J, Valero V,The hormone melatonin regulates the sleep andthis pineal hormone is synthesized in the organismfrom the amino acid tryptophan.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Search&itool=pubmed_Abstract&term=%22Cubero+J%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Search&itool=pubmed_Abstract&term=%22Valero+V%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Search&itool=pubmed_Abstract&term=%22Valero+V%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Search&itool=pubmed_Abstract&term=%22Cubero+J%22%5BAuthor%5D


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SLEEP BRUXISMRelated To Morning Headache 27 Million AmericansRelated To Increased Incidence Of OSA Suspected Shared Anatomical Cause Dr. Maurice M. Ohayon, Stanford University, January2003 CHEST


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TeenageSleep Problems


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STUDYA total of 656 boys (53.2%) and girls(46.8%), ranging in age from 13-18years were studied between Januaryand June 2004.


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357 Three hundred and fifty sevensubjects (54%)reported that they slept less thanthe suggested 6-8 hours onschooldays.


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CONCLUSIONS: These findingssupport the proposition thatadequate sleep is associated withgood health status and high-frequency adoption of health-relatedbehavior.


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Furthermore, these findings suggestthat inadequate sleep may be ascreening indicator for an unhealthylifestyle and poor health status.


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Aging and Slow Wave Sleep In a study of healthy men aged 16 to 83 yearswith no history of sleep disturbances: SWS declined from nearly 20% in earlyadulthood (age 1625 years) to 3% duringmidlife (age 3650 years) and was replaced byStage 1 and 2 sleepThis decrease was paralleled by a majordecrease in growth hormone


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Sleep need remains unchangedthroughout adulthood.Older people may wake morefrequently through the night and maysleep less, but their sleep need is noless than during young adulthood.


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When older people sleep less at night,they tend to sleep more during the daydue to sleep debt(William Dement, Stanford)Sleep difficulties are not a normal part ofaging, although they are all too commonand are TREATABLE.


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Case History:83 yr old male,SX Doesnt recognize wifeR/O stroke, tauma, toxinsDx at ER/Neuro:sudden onset late onset dementia


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Med Hx: EDTA in 1996Current Meds: NoneOrthoProtocol: good mixFamily Hx: Son with OSA


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How is your sleep?(ask the spouse too!)


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My ortho treatment:1) refer to sleep dentist JPD2) refer to sleep lab OSA3) Vitamin B shots IM4) Cal, Mag, VHP, Gingko5) Nasal O2 during sleep in to startthe day


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You added calcium and magnesiumsupplements and prescribed dailyvitamin B shots.

We administered the shot duringone of his severe memory lapses and heseemed to immediatelysnap out of it.


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Query:Does grandpa sleep lessbecause he is old?or

Is grandpa oldbecause he sleeps less?


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HOT OFF THE PRESS!Discoveryof a newand very dangeroussleep disorder!!


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Falling AsleepWhile Running a MajorCounty Disorder


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VP Cheney Sleeps During ChinesePresident Hu's Press ConferenceAFP/Getty Images From Tim Sloan


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INADEQUATECURRENTSOLUTIONS TOSLEEP DISORDERS


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MEDICATIONSAPPLIANCES

SURGERY


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COMMONLYPRESCRIBEDHYPNOTICAGENTS


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MEDICATIONS

Traditional agents do not address sleep


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composition or structure.Traditional sleep agents address only thetiming and duration of sleep (quantity) NOT

the EEG effects (quality).Agents that address the composition of sleepand improve or increase SWS may be useful(think ortho!!)


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Stimulants: Ritalin, Cylert et alAnti-Depressants: Tricyclics, MAOIAnti-Histamines: BenadrylPain Meds: Tylenol PM,Antiques: Chloral hydrate,Benzodiazepines: Xanax, Valium,Temazepam, etcBenzo-like: Ambien, LunestaOrtho knockoffs: Rozerem, Xyrem


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The benzodiazepines agonists workby acting at areas in the brainbelieved to be involved in sleeppromotion. They are the drugs ofchoice because they have the highestbenefit and the lowest risk as sleep-promoting drugs.National Sleep Foundation, 2005


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Tranquilizers (!!!) -Seroquel, Remeron, Geodon

That we are not much sicker andmuch madder than we are is dueexclusively to that most blessed andblessing of all natural graces, sleep.Aldous Huxley


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REM SleepBehavior Disorder

akaProzac eyes


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The Prozac case of Kelly SilkThis young mother attacked her family witha knife, then set the house on fire killing allbut her 8 year old daughter who ran to the

neighbors.As she stood bleeding and screaming forhelp she explained:"Help! Mommy is having a nightmare!"


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Out of the mouths of babes we willunderstand these nightmares forwhat they are.She understood that this wassomething her mother would doONLY in a nightmare, never inreality.


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This is known as aREM Sleep Behavior Disorder.Previously considered awithdrawal state,now in 86% of these cases thepatients are on SSRI meds.


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See www.drugawareness.org for importantinformation about problems with SSRI andhow they cause REM sleep disruption.See especially the role of SSRI prescribing inthe school shootings across the USA.

.Medical Legal Alert
http://www.drugawareness.org/http://www.drugawareness.org/


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Do soda pops quench thirst?(dehydration)

Does junk food cut appetite?(overfed, under nourished)

Do artificial sweeteners satisfy?(excitotoxins)


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Non- Orthosleep aidsdo not refresh.


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SURGERY

(rarely recommended)


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Appliances


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C-PAPContinuousPositive Airway Pressure

Treatment of Sleep Apnea in Heart


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Failure.Am J Respir Crit Care Med. 2006 Mar9Arzt M, Bradley TD.

Sleep Research Laboratories of theToronto Rehabilitation Institute,Toronto, ON,

However, the largest randomized
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&itool=PubMed_Abstract&term=%22Arzt+M%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&itool=PubMed_Abstract&term=%22Bradley+TD%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&itool=PubMed_Abstract&term=%22Bradley+TD%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&itool=PubMed_Abstract&term=%22Arzt+M%22%5BAuthor%5D


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trial did not demonstrate anybeneficial effect of CPAP on the rateof mortality and cardiactransplantation (32-32) but ultimatelylacked power to conclude withcertainty whether CPAP has aneffect on morbidity and mortality insuch patients.


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Plasma levels of nitric oxide and L-argininein sleep apnea patients: effects ofCPAP treatment.J Mol Neurosci. 2003;21(1):57-63.Lavie L, Technion-Israel Institute of Technology, Haifa, Israel.

Treatment with CPAP increases NO.butArginine increases NO also (with SE!!)
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Search&itool=pubmed_Abstract&term=%22Lavie+L%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Search&itool=pubmed_Abstract&term=%22Lavie+L%22%5BAuthor%5D


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DENTALAPPLIANCES


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Jaw Protrusion DevicesUncorking the Throat

TIP: Consult asleep dentist before youconsult a sleep doctor.


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ORTHO OPTIONSFORSLEEP DISORDERS

A Successful Sailing Voyage


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Requires:A Boat (the physical body)Calk for the wood and patches for the sail(the etheric or regenerative body)Wind which is changeable (the soul)Coordination of compass and rudder to staythe course despite changes in wind andweather (the spirit)

The Four Human Bodies


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Physical: relax the muscles,hot water bottle to feetopen windowEtheric: regular daily rhythmsSoul: appreciate the daySpirit: recommit to your values


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1) Lifestyle andBehavioral Habits


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We always urge people to evaluatetheir sleep habits and see what theycan change in their lives first.

Richard Gelula CEONational Sleep Foundation

Make your sleeping area comfortable


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and free of distractions.No night lights (esp. for kids)Exercise regularly, but not within 3hours before bedtime.

(granted: some exceptions.)


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Reserve your bedroom for sleep.When you get into bed, turn off thelights and prepare yourself for sleep.Dismiss worrisome thoughts.


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2) COGNITIVE


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The Busy Mindcounting your blessings is morereassuring than sheep, but countingsheep bores (relaxes) the left andright hemispheres, so bothtechniques work!


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Rueckschau(looking backwards over the daywith a bemused disinterest)a Rudolph Steiner exercise


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Oer weary and over watched,take vantage, heavy eyes, not tobehold this shameful lodging.Fortune, goodnight; smile oncemore: Turn thy wheel!-Kent in the stocks King Lear


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EFTEmotional Freedom Technique

www.geocities.com/eftadvpractitionerwww.tapyourpower.netwww.mercola.com EFT
http://www.geocities.com/eftadvpractitionerhttp://www.tapyourpower.net/http://www.mercola.com/http://www.mercola.com/http://www.tapyourpower.net/http://www.geocities.com/eftadvpractitioner


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Self- HypnosisBiofeedback LENSLow Energy Neural Stimulation

see: www.ochslabs.com
http://www.ochslabs.com/http://www.ochslabs.com/


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3) DIETARY

- Sea salt under tongue


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- Avoid alcohol, caffeine, andtobacco around bedtime.- Avoid hypoglycemia-inducingdesserts before bed.- Avoid heavy, spicy meals close tobedtime(a protein snack is okay).


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4) BIOCHEMICAL


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MineralsCalcium,Magnesium,Lithium,Boron,and correcting any other deficiency


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MAGNESIUM&

CALCIUM(Lithium & Boron)


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And when youjust add heat..


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-


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-


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Oral Mg(2+) supplementation reverses


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age-related neuroendocrine and sleepEEG changes in humans.

Pharmacopsychiatry. 2002 Jul;35(4):135-43.

Held K, Antonijevic IA,Max Planck Institute of Psychiatry,Munich, Germany

Studies could show that
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Search&itool=pubmed_Abstract&term=%22Held+K%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Search&itool=pubmed_Abstract&term=%22Antonijevic+IA%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Search&itool=pubmed_Abstract&term=%22Antonijevic+IA%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Search&itool=pubmed_Abstract&term=%22Held+K%22%5BAuthor%5D


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GABA(A) agonistMg(2+)

seems to play a key role in theregulation of sleep.

Mg(2+)


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led to asignificant increasein slow wave sleep


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Our results suggest thatMg(2+) partially reversessleep EEG

and nocturnalneuroendocrine changesoccurring during aging.


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The similarities of the effect ofMg(2+) and that of the relatedelectrolyte Li+ furthermore supportsthe possible efficacy of Mg(2+) as amood stabilizer.


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Lithium increases slow wave sleep: possiblemediation by brain 5-HT2 receptors?

Psychopharmacology (Berl). 1989;98(1):139-40.Friston KJ,

Lithium increased SWS, an effect consistentwith a reduction in brain 5-HT2 receptorfunction.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Search&itool=pubmed_Abstract&term=%22Friston+KJ%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Search&itool=pubmed_Abstract&term=%22Friston+KJ%22%5BAuthor%5D


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Amino AcidsL-Tryptophan5-HTPL-ArginineL-theanineCysteine peptides -> glutathione

Green Tea (Camille sinensis)


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Arginine-> Nitric Oxide


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Nitric Oxide in neurons of the pontinetegmentum facilitates sleep(particularly rapid-eye-movement sleep).Sleep apnea syndrome has been shown to beassociated with decreased levels of circulating

nitric oxide (NO) Vitamins


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NiacinamideInositol - potentiates tryptophanVitamin D3(helps with SAD sleepdisorder)

Oxidized glutathione promotes sleepin rabbits.


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Brain Res Bull. 1998 Apr;45(6):545-8.Kimura M, Tokyo Medical and Dental University,

Japan.

Reduced glutathione (GSH) promotes rapid-

eye-movement sleep (REMS) and non-

REMS (NREMS) in rats.Glutathione may be a sleep-inducing factor in

the brain.

Neurotransmitters
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Search&itool=pubmed_Abstract&term=%22Kimura+M%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Search&itool=pubmed_Abstract&term=%22Kimura+M%22%5BAuthor%5D


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Melatonin 1-3mg (endangered)GABA (peripheral acting)GHB (centrally acting)


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Sodium Oxybate = GHB = XyremIndications: cataplexy, excessivedaytime sleepiness (EDS);Close: fibromyalgia, Parkinsons
http://www.erowid.org/chemicals/show_molecule.php?i=ghb/ghb_3d.jpg


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-

GHB
http://www.erowid.org/chemicals/show_molecule.php?i=ghb/naghb_3d.jpghttp://www.erowid.org/chemicals/show_molecule.php?i=ghb/ghb_3d.jpg


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mol wt 104.11.C4H8O3,C 46.15%, H 7.75%, O 46.11%.HOCH2CH2CH2COOH.Naturally occurring metabolite of GABA thoughtto function as a neurotransmitter or neuro-modulator. The highest concentrations in humansis found in fetal cerebellum & adult hypothalamus.


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This is an endogenous, naturallyoccurring molecule, therefore it isorthomolecular.It was developed by Laborit (1967)who wanted to create a GABA thatcould cross the blood brain barrier.


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- 1960s used in Europe as anestheticagent as well as for alcoholdetoxification- 1970s Onset of clinical trials fornarcolepsy (Broughton, Scharf,Lammers et al)

-1980s 2 independent controlled


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studies- 1994 FDA asked Orphan todevelop sodium ascorbate- 2002 Sodium oxybate receivedFDA approval for cataplexy- 2005 approved for ExcessiveDaytime Sleepiness (EDS)

Bind to GABA 2 receptors (weak)


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Decreases cerebral glucose utilization(Cerebral protective effects!)

therefore protective during episodes ofdesaturation typical of OSA.


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Side-Effects:Dose related nausea, dizziness,somnolence, sleep terrorNot addictive,No rebound insomnia

Neuromodulator of :


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GABAHGHDopamineSerotoninEndogenous opioidsHypocretinCortisolCatecholamines

Gamma-hydroxybutyrate increasestryptophan availability and potentiates


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serotonin turnoverin rat brain.Life Sci. 2002 Mar 22;70(18):2101-12.Gobaille S, Faculte de Medecine and INSERM

GHB facilitates tryptophan transportacross the blood-brain barrier.

Web Site References:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Search&itool=pubmed_Abstract&term=%22Gobaille+S%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Search&itool=pubmed_Abstract&term=%22Gobaille+S%22%5BAuthor%5Dhttp://www.orphan.com/http://www.orphan.com/


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www.jazzpharmaceuticals.comdefinitive info on Xyremwww.ceri.comcognitive enhancement

PHENIBUT
http://www.jazzpharmaceuticals.com/http://www.ceri.com/http://www.ceri.com/http://www.jazzpharmaceuticals.com/


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4-Amino-3-phenyl butyric acidhydrochloride


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Essential Oils / Aroma TherapyLavender


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http://www.activewin.com/byron/images/digi_cam/Lavander_Bees_1.jpg


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Herbal RemediesValerian, Hops, Passiflora,Rhodeola,

Casto bean


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Castor Oil Packsapplied over liver for 30minutes before sleepduring wind down time.


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Passiflora


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Passiflora

Valerian:


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in US Dispensatory (Merck) since1849, which reported its ability toproduce drowsiness and sleep.Best if standardized tovalerenic acid


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Valarian


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Valarian flower pollen


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Hops


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Ashwaganda(Withania somnifera)

glycowithanolides (anxiolytic)vs.

withaferin or withanolides


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Leading and EsotericThoughtson theNature of Sleep


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http://www.unf.edu/~ltaylor/Pics/AET/Ansley%20Big%20Yawn.JPG


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http://www.unf.edu/~ltaylor/Pics/AET/Ansley%20Big%20Yawn.JPG


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Deep sleep => no dream recall,Lighter sleep => hazy dreams in

black and whiteLight sleep => dreams in color.

A Great Violin Recitalneeds:


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A violin - the instrument (physical body) Someone to tune the violin (etheric body) Someone who enjoys playing music (the soul) Someone who once created a sonata or who can

improvise extemporaneously (the spirit)

What happens to your


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physical body,vitality,soul and your spiritwhen you sleep?


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Spirit and Soulseparate from the

Etheric and Physical Bodies

Sleep Paralysis Fuseli (1781)


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Mexico:


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sleep paralysis is known assubida del muerto(the dead getting on top)


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Vietnam:Sleep paralysis is known as"ma ", meaning a ghost orspirit laying on top of orpressing down on the person.


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India:Hindu demons (rakshasas) attackingthose making strides towards theirown enlightenment and the good ofall mankind.

China:


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a spirit or ghost is sitting or lyingon top of the individual while theywere sleeping. This is thought tobe a minor body possession by theforces from the dead.

In traditional Russian belief,


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the symptoms reminiscent ofsleep paralysis were attributedto the anger of domovoi, thehome spirit, who was

punishing people for badhusbandship or betrayal.

The Temple Sleep


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Started by Imhotep, an Egyptianvizier, architect and highly esteemedphysician who lived around 2600BC.Imhotep built the step pyramid,which is the first pyramid.

The Temple Sleep


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In Greece (300 BC) , sleep therapysurvived in the temples of Asclepioscalled asclepieia), where people sleptovernight and reported their dreams

to a priest the following day.

Since snakes were sacred toAsclepius, they were often used in


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healing rituals.Non-poisonous snakes were left tocrawl on the floor in dormitories likean asclepieion, where the sick and

injured slept.

The Holiness of SleepI go to sleep.Till I awaken, my Soul will be in the spiritual world,


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And there will meet the higher beingwho guides me through this earthly life Him who is ever in the spiritual world,Who hovers about my head.My soul will meet him,Even the guiding genius of my life.And when I waken againThis meeting will have been.I shall have felt the wafting of his wings.The wings of my GeniusWill have touched my soul.

- Rudolf Steiner 1917

Before Going to Sleep at Night


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My ego moves consciouslyOut of the realm of the sheaths I inhabitTo rest in the Cosmic Being.It strives to make its way into the Divine.O Soul, achieve the realm!

The spirits surging sea,Lights radiant patterning.

Upon Awakening in the Morning


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Light radiating patterns,Shining surging sea of the Spirit,My soul leaves your realm.It dwelt in the Divine,its being rested in it.Into the realm of the sheaths it inhabits,

My Ego makes its conscious entrance.- Rudolf Steiner 1917


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Let us inquire of the mostauthoritative resource onimportant matters.


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The Poets

And tonight my soul may find


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her peace in sleep, and sink in goodoblivion, and in the morning wakelike a new-opened flower.Then I have been dipped againin God and new-created.

D.H. Lawrence Shadows

The Night House by Billy Collins, P.L.


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Every day, the body worksin the fields of the worldmending a stone wallor swinging a sicklethrough the tall grass the grass of civics, the grass of money--

And every night


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the body curls arounditselfand listens for the softbells of sleep.


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But the heart is restless and risesfrom the body in the middle of the night,leaves the trapezoidal bedroomwith its thick, pictureless wallsto sit by herself at the kitchen tableand heat some milk in a pan.

And the mind gets up too,puts on a robe


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and goes downstairs,lights a cigarette,and opens a bookon engineering.

Even the conscience awakens


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and roams from room to roomin the dark,darting away from every mirror like astrange fish.

And the soul is up on the roof


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in her nightdress,straddling the ridge,singing a songabout the wildness of the seauntil the first rip of pinkappears in the sky.

Then, they all will returnto the sleeping body


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the way a flock of birdssettles back into a tree,resuming their daily colloquy,talking to each otheror themselves

even through the heatof the long afternoons.

Which is why the body that house of voices


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sometimes puts downits metal tongs,its needle, or its pento stare into the distance,to listen to all its namesbeing calledbefore bending again to its labor.


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SUMMARY

Sleep is a


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dynamic processthat is characterized byperiodic changes inelectrophysiologic activity.

Restorative Sleep is an


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active and fundamentalprocess required foroptimal health both psyche & soma!


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Disrupted sleepaggravates all illnessesand disease states.

Most of your patients are


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not really asleep at nightand that is why they arenot really refreshed in the

morning.

Most of your patients


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havegiven up ongetting agood nights sleep.

Most of your patients


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who are on sleeping pillsare taking dangeroussubstances which may induceparasomnias

(sleep driving)


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and whichmay interferewith theirspiritual development.


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Only orthoapproaches serve tocorrect this problem.

Safe


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EffectiveCost EffectiveGrateful Patients


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The Rest of Your Daysdepend(s) uponThe Rest of Your Nights

Thank you !


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and now, you may go back tosleep.Sleep Well!email questions to [email protected]

Bradford S. Weeks, M.D.
mailto:[email protected]:[email protected]


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The Weeks ClinicConsultants forCorrective Medicine and Psychiatry

"ortho" approaches to correcting sleep disruption

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