organs-on-chips market and technology landscape...
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From Technologies to Markets
© 2019
From Technologies to Markets
© 2019
Organs-on-chips Market and Technology
Landscape 2019
Market and Technology Report
Sample
2
Glossary and definitions p.2
Table of contents p.3
Report objectives p.5
Report scope p.6
Report methodology p.7
About the authors p.8
Companies cited in this report p.9
What we got right, What we got wrong p.10
Who should be interested by this report? p.11
Yole Group related reports p.12
Executive Summary p.13
Context p.59
o A problem to solve
o Other alternatives – which is best?
o Limitations of alternative methods (2D cell culture, 3D cell culture, organoids,
animal models, bioprinting)
o The big picture: a huge potential in a huge market
o Users and applications
o Drugs side effects and toxicity
o Main toxicity issues
o Future vision: personalized medicine
o What is an organ-on-chip?
o Is an organ-on-chip a real organ?
o Which organs can be emulated?
o What makes organ-on-chip technology relevant?
o How to ensure the models are relevant?
o Body on a chip: connecting several organs for a global understanding
o Organ-on-chip disease models
o Endpoints: what is measured?
o Summary
Market forecasts p.87
o Introduction
o How are OOC companies making revenue today?
o Business models
o Assumptions
o Market data and forecasts - comparison between the 2017 report and this report
o Market data and forecasts in value
o Market data and forecasts in units
o ASP evolution
o Conclusions
Market trends p.106
o Applications
o End-users have mitigated opinions about OOC
o How pharmaceutical companies are using OOC
o Relationship between OOC developers and pharmaceutical companies
o Application outside the pharmaceutical industry
o OOC won’t replace current workflows in the foreseeable future
o What’s the demand of the end-users?
o Expected impact on the industry
Organs-on-chips Market and Technology Landscape 2019 | Sample | www.yole.fr | ©2019
TABLE OF CONTENTS
Part 1/2
Imec’s organ-on-chip platform fuses imec’s high-density multi-electrode array (MEA)-chip with a microfluidic well plate, developed in collaboration with Micronit Microtechnologies, in which cells can be cultured, providing an environment that mimics human physiology
3Organs-on-chips Market and Technology Landscape 2019 | Sample | www.yole.fr | ©2019
TABLE OF CONTENTS
Part 2/2
o Too many OOC companies? The gap between established players and
newcomers
o Status of the market
o Public funding
o The role of regulators
o Challenges to address
o Who will use the OOC in the future?
o The OOC market paradox
o Where are we today?
o What do we expect?
o Conclusions
Market shares and supply chain p.134
o Organ-on-a-chip companies – geographical location
o Organ-on-chip ecosystem
o Market shares in value in 2018
o Evolution of the OOC companies’ revenue
o Fundraising table
o Manufacturing: who’s working with whom?
o Possible evolution and structuration of the market
o Could OOC companies purchase microfluidic fabs?
o Appearance of dedicated OOC CROs
o Value chain: cost of making a functioning organ-on-chip
o Conclusions
Technology trends p.146
o Who’s doing which organs matrix
o Most widespread organ models (ranking)
o End-users technical requirements
o Comparison of the different technologies
o Current limitations
o How many OOC are used?
o Two types of OOC: chips and plates
o Different types of OOC for different drug development stages
o From chip to plate
o Different types of OOC at different prices
o Single-organ vs. multi-organ models
o Towards a “human-on-a-chip”?
o Membrane-based devices
o Key aspects of organs-on-chips
o Different flow control modalities
o Where does microfluidics add value?
o Materials and manufacturing
o Materials change
o Material mix
o Emergence of new materials
o Towards an increased use of silicon in OOC?
o OOC instruments
o The importance of cells and biology
o Cell sources
o Disease models
o Conclusions
Company profiles p.189
Conclusions p.199
Yole Développement presentation p.202
4
Marjorie Villien
As a Technology & Market Analyst, Medical & Industrial Imaging, Marjorie Villien, PhD., is member of the Photonics & Sensing activities group at YoleDéveloppement (Yole).
Marjorie contributes regularly to the development of imaging projects with a dedicated collection of market & technology reports as well as custom consulting services in the medical and industrial fields. She regularly meets with leading imaging companies to identify and understand technology issues, analyze market evolution and ensure the smart combination of technical innovation and industrial application.
After spending two years at Harvard and prior to her position at Yole, Marjorie served as a research scientist at INSERM and developed dedicated medical imaging expertise for the diagnosis and follow-up treatment of Alzheimer’s disease, stroke and brain cancers.
She presents to numerous international conferences throughout the year and has authored or co-authored 12 papers and 1 patent.
Marjorie Villien graduated from Grenoble INP (France) and holds a PhD. in physics & medical imaging.
Email: [email protected]
Sébastien Clerc
Sébastien Clerc is a Technology & Market Analyst in Microfluidics, Sensing & Actuating atYole Développement (Yole).
As part of the Photonics & Sensing team, Sébastien has authored a collection of market and technology reports dedicated to microfluidics and othermicro-devices for both market segments: medical (including diagnostics, pharmaceutical, biotechnology, drug delivery, medical devices) and industrial(including environment, agro-food).
At the same time, he is involved in custom projects such as strategic marketing, technology scouting and technology evaluation to help academic andindustrial players in their innovation processes. Thanks to his technology & market expertise, Sébastien has spoken in more than 20 industryconferences worldwide over the last 4 years.
Sébastien Clerc graduated from Grenoble Institute of Technology (Grenoble INP - Grenoble, France) with a Master’s degree in BiomedicalTechnologies. He then completed his academic studies with a Master’s degree in Innovation and Technology Management in the same institute.
Email: [email protected]
Organs-on-chips Market and Technology Landscape 2019 | Sample | www.yole.fr | ©2019
ABOUT THE AUTHORS
Biographies & contacts
5
4Design Biosciences, AIM Biotech, Allevi, Alnylam, AlveoliX, Amgen, Amore Pacific, Ananda Devices,Aspect Biosystems, Astellas, AstraZeneca, AxoSim, BASF, Barcelona Liver Bioservices, Beiersdorf,BeOnChip, Bioclinicum, Biogen, BiomimX, BI/OND, Bristol-Myers Squibb, Charles River, Charles StarkDraper Laboratory (Draper), CN Bio Innovations, CorSolutions, Covance, Creo Bioscience, Curiochips,DARPA, Denz Bio-Medical, Eli Lilly, Elveflow, Emulate, EpiSkin, ESA, Fluigent, Galapagos, GlaxoSmithKline(GSK), Harvard Medical School, Hesperos, Hurel Corporation, ICON plc, imec, InSphero, INTENZEProducts, Iontox, IQVIA, Javelin Biotech, Jiksak Bioengineering, Johnson & Johnson, Kirkstall, L’Oréal,Massachusetts Institute of Technology (MIT), Merck, MicroBrain Biotech, Microfluidic ChipShop,Micronit, Mimetas, MiniFAB, NASA, NCATS, NIH, Nortis, Organovo, Parexel, Parker Hannifin, Pfizer,Philip Morris, PimBio, Roche, Sanofi, Seattle Bioscience, Seres Therapeutics, Sigma-Aldrich, StemoniX,Stratec Consumables, Sun Bioscience, Syneos Health, Synvivo, Tara Biosystems, Tebu-bio, TissUse,Vanderbilt University, Vertex Pharmaceuticals, WYSS Institute, Xona Microfluidics, Yale University, andmore.
Organs-on-chips Market and Technology Landscape 2019 | Sample | www.yole.fr | ©2019
COMPANIES CITED IN THIS REPORT
200+ slides of market and technology analysis
Information gathered through direct discussions with players all along the supply chain
6
This new Yole Développement report provides a complete analysis of the organ-on-chip market and technologyfields:
o New major trends and evolutions in the organ-on-chip industry market, feedback from end-users,evolution of business models, evolution of the hype
o Analysis of the requirements to boost the adoption of the technology and make organs-on-chips a successstory
o Updated market data and forecast up to 2024, in value and units, for organ-on-chip devices sales andservices
o Comparison with our 2017 report’s data and analysis
o Supply chain and ecosystem description and analysis, with projection future evolution
o Technical analysis: type of organ models, type of devices, importance of flow control, importance of cellsources, material mix, etc.
Organs-on-chips Market and Technology Landscape 2019 | Sample | www.yole.fr | ©2019
REPORT OBJECTIVES
7
We consider as organ-on-a-chip devices a combination of microtechnology and biology. All the deviceswe consider are micro-structured with injection molding or semiconductor-derived techniques.
Organs-on-chips result of the convergence of several areas of research:
• Microfluidics
• Microfabrication
• Tissue engineering
• Stem cell biology (providing easy access to non-malignant human cell lines and to patient-specific stemcells, enabling the creation of general human models and patient-specific models)
Other cell culture alternatives such as 3D cell culture, organoids and spheroids, are not part of thereport’s scope.
Organs-on-chips Market and Technology Landscape 2019 | Sample | www.yole.fr | ©2019
REPORT SCOPE
Yours needs are
out of the report’s
scope?
Contact us for a custom:
8Organs-on-chips Market and Technology Landscape 2019 | Sample | www.yole.fr | ©2019
REPORT METHODOLOGY
Market
Volume (in Munits)
ASP (in $)
Revenue (in $M)
Yole’s market forecast model is based on the matching of several sources:
Information
Aggregation
Preexisting
information
9Organs-on-chips Market and Technology Landscape 2019 | Sample | www.yole.fr | ©2019
WHO SHOULD BE INTERESTED IN THIS REPORT?
Pharmaceutical, cosmetics, agro-food, chemistry, consumer goods and other companies, including CROs:
o To understand what are organ-on-chip technologies
o To understand what is the state of the art and which solutions could bring operational benefits versus other technologies
o To identify the different organs-on-chips players, types of organs emulated and specificities of the different models
o To understand behavior evolution
R&D players:
o To understand new challenges linked to organs-on-chips
o To address the right market with the right technology
Financial & strategic investors:
o To understand the potential for organ-on-chips
o To know the latest moves within the industry
o To get a list and description of OOC players
o To understand which are the sweet spots and what are the end-users pushing for
Organ-on-chip developerso To monitor and benchmark potential
competitorso To understand how to address the
right market with the right technologyo To understand the end-users
requirements and adapt their offer
Microfluidic foundries and device makers:
o To understand technical requirementso To identify business opportunities and
prospects
Healthcare and governmental organizations:
o To evaluate benefits of OOC technologies
o To identify relevant companies
10Organs-on-chips Market and Technology Landscape 2019 | Sample | www.yole.fr | ©2019
CONTEXT
A problem to solve (1/2)
5k – 10k
compounds
100 – 500
compounds
50 – 250
compounds 1 compound
CommercializationDrug discovery Preclinical trials Clinical trials ValidationPreclinical research
3 – 5
compounds
Total cost: $2.6 billion in average
5+ years 10+ years 12+ years
11Organs-on-chips Market and Technology Landscape 2019 | Sample | www.yole.fr | ©2019
CONTEXT
A problem to solve (2/2)
In-development drugs have a very high failure rate in clinical trials.
In many cases, drugs have different effects on 2D cell cultures and
animals vs. humans: around 90% of drugs validated on animals
during pre-clinical trials fail during human clinical trials.
Thus there is a need for solutions that enable better predictive, physiologically-relevant in-
vitro drug testing. This could save hundreds of millions of dollars in development costs and
avoid major timeline delays for a single drug.
In many cases, cell models, 3D culture models, and animal models do not adequately
represent human biology. Consequently, a large part of the total pharma R&D budget is spent
on drugs that ultimately fail in human clinical trials.
12
Organs-on-chips result of the convergence of several areas of research:
• Microfluidics
• Microfabrication
• Tissue engineering
• Stem cell biology (providing easy access to non-malignant human cell lines and to patient-
specific stem cells, enabling the creation of general human models and patient-specific models)
CONTEXT
What is an organ on a chip? (1/2)
It is a micro-engineered device lined with living human cells, which model and reconstitute the physiological and mechanical functions of a human organ.
Organs-on-chips Market and Technology Landscape 2019 | Sample | www.yole.fr | ©2019
A combination of microtechnology…
… and biology
Fraunhaufer IGB’s retina-on-a-chip
Lung-on-a-chip model developed at the WYSS Institute
13Organs-on-chips Market and Technology Landscape 2019 | Sample | www.yole.fr | ©2019
CONTEXT
What is an organ on a chip? (2/2)
• It is a micro-engineered device lined with living human cells, which model and reconstitute the physiological and mechanicalfunctions of a human organ
• Microfabrication techniques coming from the semiconductor industry allows to control the features of the bioengineered organat a microscale or below, which is similar to the cell scale at the organ level.
• Current product applications:
• Understanding biological mechanisms for novel drug targets
• Providing insight into disease processes
• Predicting the efficacy and safety of new drug candidates
• Screening using much lower drug amounts
• Explore species differences and unexpected clinical findings
• Implementation of 3Rs – reduction, refinement and replacement – of animal testing
• Toxicity tests
• Development of clinical diagnostics
• Personalized health applications
• Organs on chips can be used in a variety of domains:
• Pharmaceutical companies: drug development, disease modeling, toxicity test, personalized medicine…
• Cosmetics: toxicity screening…
• Environment health: chemicals, air, food…
Mimetas kidney on a chip
14
Bio-technology
Academia
Chemicals and
environmentPharmaceutical
AgricultureCosmetics
CONTEXT
Markets and applications
The applications of organs-on-chip are ranging from toxicity test to drug discovery.
Drug discovery
Personalized medicine
Safety/ toxicity test
Drug efficacy
Disease modeling
Markets Applications
Organs-on-chips Market and Technology Landscape 2019 | Sample | www.yole.fr | ©2019
15Organs-on-chips Market and Technology Landscape 2019 | Sample | www.yole.fr | ©2019
CONTEXT
Drug side effects and toxicity
• Though physicians prescribe drugs to prevent or treat disease, these drugs can be harmful to certain patients because ofinappropriate use (high dose or drug-drug interaction), non-selective action, age of the patient or genetic predisposition.
• Indeed, all drugs may have both primary intended effects and unintended secondary side effects which can be undesirable.
16Organs-on-chips Market and Technology Landscape 2019 | Sample | www.yole.fr | ©2019
CONTEXT
Main toxicity issues
The liver and kidney are particularly susceptible to
organ toxicity, as they are in charge of toxin
filtration and toxin metabolic breakdown.
The use of a drug, particularly when repeated, can lead to an accumulation of harmful compounds in tissues or organs from
the metabolism of this drug. This accumulation of toxic compounds can lead to organ damage or even organ failure and death.
The heart is also one of the organs the most
commonly affected by drug toxicity (especially with
chemotherapy drugs).
Moreover, many other organs can be affected by drug
toxicity, either directly or via drug metabolites (e.g.
generated by the liver following the intake of the drug).
17
CONTEXT
Future vision: personalized medicine (1/2)
Individually tailored Organs-on-Chips with a patient’s own cells, to allow biology to be predicted on a person-by-person basis.
Organs-on-chips Market and Technology Landscape 2019 | Sample | www.yole.fr | ©2019
Now
Personalized
organs on chip
containing
one’s personal
living cells
18
CONTEXT
Future vision: personalized medicine (2/2)
Everyone will benefit from personalized organs on chips.
Organs-on-chips Market and Technology Landscape 2019 | Sample | www.yole.fr | ©2019
• For pharmaceutical companies, personalized testing means that drugs that so far failed to show efficacy forthe global patient population could be marketed for the specific pool of patients where they do work. Thiscould be a significant new source of revenues for the pharmaceutical industry.
• For patients, personalized testing means to pre-select the medications that work for them (depending on age,gender, genetic predispositions…), resulting altogether in more effective and cost-effective therapies.
19Organs-on-chips Market and Technology Landscape 2019 | Sample | www.yole.fr | ©2019
MARKET DATA AND FORECASTS
20Organs-on-chips Market and Technology Landscape 2019 | Sample | www.yole.fr | ©2019
MARKET TRENDS (1/2)
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MARKET SHARES AND SUPPLY CHAIN (1/2)
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TECHNOLOGY TRENDS
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TECHNOLOGY TRENDS
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COMPANY PROFILES
25
Contact our
Sales Team
for more
information
Liquid Biopsy: From Isolation to Downstream Applications 2018
Next-Generation Sequencing & DNA Synthesis 2019
Status of the Microfluidics Industry 2019
Point-of-Need Testing: Application of Microfluidic
Technologies 2018
Organs-on-chips Market and Technology Landscape 2019 | Sample | www.yole.fr | ©2019
Yole Développement
Organs-on-chips (OOC) has the potential to enable better predictive, physiologically-relevant in-vitro drug testing. This could save hundreds of millions of dollars in development costs, reduce drug development time, and avoid failures due to lack of predictiveness from alternative models like 2D cell cultures and animals. Burgeoned by these promises, the OOC market increased 4-fold from 2016 - 2018 (from $7.5M to $29.6M), and will grow at a CAGR2018-2024 of 28,6%.
Many new players are entering this market with new organ models, and most players that were present two years ago have made noticeable progress. Top players like Mimetas and TissUse now have recurring sales and a consistent revenue stream, and many players are leveraging their OOC devices to provide testing services to
their partners in the pharmaceutical, cosmetics, and consumer goods industries - for testing the efficacy and safety of new drugs and products. Evolving regulations in certain countries and industries have spurred a push towards the use of in-vitro models instead of animal models. In the pharmaceutical industry, the real potential of the technology conclusively lies in the promise it holds for personalized medicine. Indeed, it could be possible to create individually-tailored OOC with a patient’s own cells, allowing a substance’s effects to be predicted on an individual basis. In this report, Yole Développement’s (Yole) analysts explain how reaching such milestones could create a real inflexion point, causing the OOC market to skyrocket. However, this is a long-term vision that will not materialize over the next five years.
ORGANS-ON-CHIPS MARKET AND TECHNOLOGYLANDSCAPE 2019Market & Technology Report - October 2019
Market growth is pushing changes in materials and technologies.
WHAT’S NEW• What has happened in the last two years • What we got right, what we got wrong • Updated and refined market forecasts and assumptions • Market-share evolution • Identification of new entrants • Analysis of the role of various players, including contract research organizations• Evolution of the materials mix, and future projections
KEY FEATURES• Major trends and evolutions in the organs-on-chips industry, feedback from end-users, evolution of business models, evolution of “the hype” • Analysis of the requirements to boost the technology’s adoption and make organs-on-chips a success story • Updated market data and forecast up to 2024, in value and units for organ- on-chip device sales and services • Comparison with Yole Développement 2017 report’s data and analysis • Supply chain and ecosystem description and analysis, with projections for future evolution • Technical analysis: type of organ models, device types, importance of flow control, importance of cell sources, materials mix, etc.
TOO MANY EXPECTATIONS, TOO MUCH HYPE?
$12.5$M (42%)
$29.6M2018
2024Revenue from sales of organ-on-chips devices
Revenue from testing services
*CAGR2018-2024 = +28.6%
$60.8$M(45%)
$133.9M
$17$M (58%) $73.0$M
(55%)
*CAGR: Compound Annual Growth Rate
Since OOC holds great promise, the associated expectations are extremely high. Personalized medicine, fully replacing current in-vitro and in-vivo models, for disease modelling? We have entered a phase where end-users don’t expect such results yet - but they do expect reproducibility and automation. Though OOC companies claim to have positive feedback from end-users overall, the comments from end-users are more restrained. The problem is that most OOC models are still “proof-of-concept”, whereas end-users prefer industry-grade models with validated processes
and outcomes. In this report, Yole’s analysts explain the reasons for such negative feedback, and what the end-users’ expectations are.
OOC technology is intriguing, but it is struggling to generate a consensus. Consequently, OOC companies strain to find the ideal business model: most end up adopting a hybrid business model combining product sales and services, because even though different users have different demands, OOC firms cannot say “no”. Ultimately though, each company must find the right balance inspired by its strengths, instead of trying to please every customer.
(Yole Développement, October 2019)
A RAPID PACE FOR A HIGH-POTENTIAL MARKET
Organs-on-chips market: 2018 - 2024 forecast
ORGANS-ON-CHIPS IS A MULTIDISCIPLINARY FIELD, AND VARIOUS PARAMETERS WILL SHAPE TOMORROW’S TECHNOLOGY
Organs-on-chips user chain: Midterm future prediction*
1
ORGAN-ON-CHIPS USER CHAIN: MID-TERM FUTURE PREDICTION
Organs-on-chips companies
Contract research organizations
Pharmaceutical companies
Provide organs-on-chips devices and models
Offer testing services on organs-on-chips
Non-exhaustive list of companies
(Yole Développement, October 2019)
REPORT OBJECTIVES• Detail new major trends and evolutions in the OOC industry • Evaluate end-users’ feedback, and the impact it has on the evolution of business models, hype, etc. • Discern end-users’ key requirements for widespread adoption of the technology, and where the gap is today • Provide updated market data and forecasts up to 2024, in value and units for OOC device sales and services, and a comparison with our 2017 report’s data and analysis • Describe the supply chain and ecosystem, and discuss future evolutions • Deliver a comprehensive technical analysis: type of organ models, device types, importance of flow control, importance of cell sources, evolution of the materials mix, etc.
The OOC industry’s maturation could signal the beginning of contract research organizations’ (CROs) involvement. Today, CROs seem minimally involved in the OOC field, and are waiting for more evidence of the technology’s potential. However, CROs are usually the privileged subcontractors of the pharmaceutical, cosmetics, and consumer goods industries for safety and efficacy testing - and in a midterm future, they will certainly be the primary users of OOC in order to perform testing services for the pharma industry. Also, they will work closely with OOC companies to learn how to best use their models. That said, it’s too early to speculate, and additional data must be generated to prove OOC’s relevance over the gold standards CROs have used for decades.
ORGANS-ON-CHIPS MARKET AND TECHNOLOGY LANDSCAPE 2019
*Non exhaustive list of companies
2024
13 %
21 %
56 %
10 %PDMSPolymerGlassSilicon
2016
18 %
15 %
67 %
2018
20 %
54 %
25 %
36 kUnits
146kUnits
790 kUnits
*CAGR: Compound Annual Growth Rate
Volume CAGR*2018-2024= + 32,4%
(Yole Développement, October 2019)
Evolution and forecast of the organs-on-chips material mix in volume
*Non exhaustive list of companies
Organs-on-chips can take various shapes and appearances, depending on their purpose. The drug development process is long and complex, and the needs are not the same at the early drug-screening stages as they are in the late preclinical trial stages. Thus, we see some players specializing in plate formats for automation and high throughput, while others prefer developing single independent chips.
Some players develop key solutions based on single organ models, while others propose multi-organ models to assess metabolic interactions between organs. Every technology is different and has specific application domains.
On the materials side, important changes are happening. Two years ago, Yole’s analysts were concerned about the ability of OOC companies to switch from PDMS devices in order to scale-up production. Today, it appears that most companies have successfully managed this transition, or at least engaged with the right partners early enough to avoid the problems young companies usually face at this stage. At the moment, polymer is the preferred material, but some companies use glass. The next step could be the integration of more silicon pieces: indeed, sensing directly at the cell level is a necessity, but right now only a few companies are moving in this direction. This is why silicon is not commonly used in OOC. Yole’s analysts expect this to change by 2024, and in this report they detail the evolution of the materials mix, along with various other technical aspects such as the added-value of flow control and vascularization of organs, the emergence of new materials combining the preferred properties of several existing ones, the importance of cell sources, and more.
COMPANIES CITED IN THE REPORT (non exhaustive list)
4Design Biosciences, AIM Biotech, Allevi, Alnylam, AlveoliX, Amgen, Amore Pacific, Ananda Devices, Aspect Biosystems, Astellas, AstraZeneca, AxoSim, BASF, Barcelona Liver Bioservices, Beiersdorf, BeOnChip, Bioclinicum, Biogen, BiomimX, BI/OND, Bristol-Myers Squibb, Charles River, Charles Stark Draper Laboratory (Draper), CN Bio Innovations, CorSolutions, Covance, Creo Bioscience, Curiochips, DARPA, Denz Bio-Medical, Eli Lilly, Elveflow, Emulate, EpiSkin, ESA, Fluigent, Galapagos, GlaxoSmithKline (GSK), Harvard Medical School, Hesperos, Hurel Corporation, ICON plc, imec, InSphero, INTENZE Products, Iontox, IQVIA, Javelin Biotech, Jiksak Bioengineering, Johnson & Johnson, Kirkstall, L’Oréal, Massachusetts Institute of Technology (MIT), Merck, MicroBrain Biotech, Microfluidic ChipShop, Micronit, Mimetas, MiniFAB, NASA, NCATS, NIH, Nortis, Organovo, Parexel, Parker Hannifin, Pfizer, Philip Morris, PimBio, Roche, Sanofi, Seattle Bioscience, Seres Therapeutics, Sigma-Aldrich, StemoniX, Stratec Consumables, Sun Bioscience, Syneos Health, Synvivo, Tara Biosystems, Tebu-bio, TissUse, Vanderbilt University, Vertex Pharmaceuticals, WYSS Institute, Xona Microfluidics, Yale University, and more.
Glossary and definitions 2Table of contents 3Report objectives 5 Report scope 6
Report methodology 7
About the authors 8
Companies cited in this report 9What we got right, what we got wrong 10Who should be interested in this report? 11 Yole Group’s related reports 12Executive summary 13Context 51
> A problem to solve > Limitations of alternative methods (2D cell culture, 3D cell culture, organoids, animal models, bioprinting) > The big picture: huge potential in a huge market > Future vision: personalized medicine > What is an organ-on-chip? > What makes OOC technology important? > Body-on-a-chip: connecting several organs for a comprehensive understanding > Organ-on-chip disease models
Market forecasts 79> How are OOC companies generating revenue today? > Business models > Assumptions > Market data and forecasts: comparison between the 2017 report and this report > Market data and forecasts, in value and units > ASP evolution
Market trends 96> Relationship between OOC developers and pharmaceutical companies
> Applications beyond the pharmaceutical industry > OOC won’t replace current workflows in the foreseeable future > What’s the demand from end-users? > Market status > The OOC market paradox > Where are we today? > What do we expect?
Market share and supply chain 123> Organ-on-chip companies - geographic location> Organ-on-chip ecosystem> 2018 market share, in value > Evolution of OOC companies’ revenue> Fundraising table> Manufacturing: who’s working with whom?> Possible market evolution and structuration > Appearance of dedicated OOC CROs> Value chain: cost of making a functioning organ-on-chip
Technology trends 137> Who’s doing which organs: matrix> Most widespread organ models (ranking)> Current limitations> Two types of OOC: chips and plates> Different OOC types for different drug development stages> From chip to plate> Different OOC types at different prices> Different flow-control modalities> Where does microfluidics add value?> Materials and manufacturing> Emergence of new materials> Towards an increased use of silicon in OOC?
Company profiles 176Conclusions 186Yole Développement presentation 189
TABLE OF CONTENTS (complete content on i-Micronews.com)
• Status of the Microfluidics Industry 2019 • Point-of-Need Testing: Application of Microfluidic Technologies 2018• Liquid Biopsy: From Isolation to Downstream Applications 2018
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AUTHORSSébastien Clerc works as a Technology & Market Analyst, Microfluidics, Sensing & Actuating at Yole Développement (Yole). As part of the Photonics & Sensing activities, Sébastien has authored a collection of market and technology reports dedicated to microfluidics and other micro-devices for both market segments: medical (including diagnostics, pharmaceutical, biotechnology, drug delivery, medical devices) and industrial (including environment, agro-food). In parallel, he is daily involved in custom projects such as strategic marketing, technology scouting and technology evaluation to help academic and industrial players in their innovation processes. Thanks to his technology & market expertise, Sébastien has spoken in more than 20 industry conferences worldwide over the last 4 years. Sébastien Clerc graduated from Grenoble Institute of Technology (Grenoble INP - Grenoble, France) with a Master’s degree in Biomedical Technologies. He then completed his cursus with a Master’s degree in Innovation and Technology Management in the same institute.
Marjorie Villien, PhD. is Technology & Market Analyst, Medical & Industrial Imaging at Yole Développement (Yole).As a member of the Photonics & Sensing activities, Marjorie contributes regularly to the development of imaging projects with a dedicated collection of market & technology reports as well as custom consulting services in the medical and industrial fields. She regularly meets with leading imaging companies to understand technology issues, analyze market evolution and ensure the smart combination of technical innovation and industrial application.Marjorie Villien graduated from Grenoble INP (France) and holds a PhD. in physics & medical imaging.
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Founded in 1998, Yole Développement (Yole) has grown to become a group of companies providing marketing, technology and strategy consulting, media and corporate finance services, reverse engineering and reverse costing services and well as IP and patent analysis. With a strong focus on emerging applications using silicon and/or micro manufacturing, the Yole group of companies has expanded to include more than 120 collaborators worldwide covering MEMS and image sensors, Compound semiconductors, RF Electronics, Solid-state lighting, Displays, Software, Optoelectronics, Microfluidics & Medical, Advanced Packaging, Manufacturing, Power Electronics, Batteries & Energy Management and Memory.The “More than Moore” market research, technology and strategy consulting company Yole Développement, along with its partners System Plus Consulting, PISEO, KnowMade and Blumorpho, supports industrial companies, investors and R&D organizations worldwide to help them understand markets and follow technology trends to grow their business.
CONSULTING AND ANALYSIS• Market data & research, marketing analysis• Technology analysis• Strategy consulting• Reverse engineering & costing• Patent analysis• Design and characterization of innovative optical systems• Financial services (due diligence, M&A with our partner)More information on www.yole.fr
MEDIA & EVENTS• i-Micronews.com website, application & related e-newsletter• Communication & webcast services• Events: TechDays, forums…More information on www.i-Micronews.com
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From Technologies to Market
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YOLE DEVELOPPEMENT – FIELDS OF EXPERTISE WITHIN 3 MAIN DOMAINS
Semiconductor & Softwareo Semiconductor Packaging and Substrates
o Semiconductor Manufacturing
o Memory
o Computing and Software
Power & Wireless
o RF Devices & Technologies
o Compound Semiconductors & Emerging
Materials
o Power Electronics
o Batteries & Energy Management
Photonics & Sensingo Photonics
o Lighting
o Imaging
o Sensing & Actuating
o Display
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4 BUSINESS MODELS
o Consulting and Analysis
• Market data & research,
marketing analysis
• Technology analysis
• Strategy consulting
• Reverse engineering & costing
• Patent analysis
• Design and characterization
of innovative optical systems
• Financial services (due
diligence, M&A with our
partner)
www.yole.fr
o Syndicated reports
• Market & technology reports
• Patent investigation and patent
infringement risk analysis
• Teardowns & reverse costing
analysis
• Cost simulation tool
www.i-Micronews.com/reports o Media
• i-Micronews.com website and
application
• i-Micronews e-newsletter
• Communication & webcast
services
• Events: TechDays, forums,…
www.i-Micronews.com
o Monitors
• Monthly and quarterly update
• Excel database covering supply,
demand, and technology
• Price, market, demand and
production forecasts
• Supplier market shares
www.i-Micronews.com/reports
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6 COMPANIES TO SERVE YOUR BUSINESS
Due diligence
www.yole.fr
Manufacturing costs analysis
Teardown and reverse engineering
Cost simulation tools
www.systemplus.fr
Market, technology and strategy
consulting
www.yole.fr
IP analysis
Patent assessment
www.knowmade.fr
Innovation and business maker
www.bmorpho.com
Design and characterization of
innovative optical systems
www.piseo.fr
Yole Group of Companies
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OUR GLOBAL ACTIVITY
30%of our business
40%of our business 30%
of our business
Greater
China office
Yole Japan
HQ in Lyon
Nantes
Paris
Nice
Vénissieux
Yole Deutschland
Frankfurt
Hsinchu
Tokyo
Yole Korea
Seoul
Palo Alto
Yole Inc.
Cornelius
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ANALYSIS SERVICES - CONTENT COMPARISON
High
Technology
and Market
Report
Leadership
Meeting
Q&A
Service
Depth of the analysis
Bre
adth
of th
e a
nal
ysis
Meet the
Analyst
Custom
Analysis
High
Low
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SERVING THE ENTIRE SUPPLY CHAIN
Our analysts provide market analysis,
technology evaluation,
and business plans along the entire
supply chain
Integrators, end-
users and software
developers
Device manufacturers
Suppliers: material,
equipment, OSAT, foundries…
Financial investors, R&D centers
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SERVING MULTIPLE INDUSTRIAL FIELDS
We workacross
multiples industries to understand
the impact of More-than-
Moore technologies from deviceto system
From A to Z…
Transportation
makers
Mobile phone
and
consumer
electronics
Automotive
Medical
systems
Industrial
and defense
Energy
management
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o Over the course of more than 20 years, Yole Développement has grown to become a group of companies. Together with System Plus Consulting and KnowMade, we now
provide marketing, technology and strategy consulting, media and corporate finance services, reverse costing, structure, process and cost analysis services and well as
intellectual property (IP) and patent analysis. Together, our group of companies is collaborating ever closer and therefore will offer, in 2019, a collection of over 125 reports,
10 new monitors and 120 teardowns. Combining respective expertise and methodologies from the three companies, they cover:
o If you are looking for:
• An analysis of your product market and technology
• A review of how your competitors are evolving
• An understanding of your manufacturing and production costs
• An understanding of your industry’s technology roadmap and related IPs
• A clear view supply chain evolution
Our reports and monitors are for you!
o Our team of over 70 analysts, including PhD and MBA qualified industry veterans from Yole Développement, System Plus Consulting and KnowMade, collect information,identify trends, challenges, emerging markets, and competitive environments. They turn that information into results and give you a complete picture of your industry’slandscape. In the past 20 years, we have worked on more than 2,000 projects, interacting with technology professionals and high-level opinion makers from the mainplayers of their industries and realized more than 5,000 interviews per year.
WHAT TO EXPECT IN 2019?In 2019 we will extend our offering with a new ‘monitor’ product which provides more updates on your industry during the year. The Yole Group of Companies is also buildingon and expanding its investigations of the memory industry. Moreover, in parallel, the Yole Group reaffirms its commitment to a new collection of reports mixing software andhardware and is increasing its involvement in displays, radio-frequency (RF) technology, advanced substrates, batteries and compound semiconductors. Last but not least,System Plus Consulting is developing its teardowns service providing 120+ offers related to phones, smart home, wearables and connected devices. Discover our 2019program right now, and ensure you get a true vision of the industry. Stay tuned!
REPORTS COLLECTION
www.i-Micronews.com
• MEMS & Sensors
• RF devices & technologies
• Medical technologies
• Semiconductor Manufacturing
• Advanced packaging
• Memory
• Batteries and energy management
• Power electronics
• Compound semiconductors
• Solid state lighting
• Displays
• Software
• Imaging
• Photonics
About Yole Développement | www.yole.fr | ©2019
35
OUR 2019 REPORTS COLLECTION (1/4)
18 fields of excellence combined with six markets to provide a complete picture of your industry landscape
Market –Technology – Strategy – by Yole DéveloppementYole Développement (Yole) offers market reports including quantitative market forecasts,
technology trends, company strategy evaluation and indepth application analyses. Yole will
publish more than 55 reports in 2019, with our partner PISEO contributing to some of
the lighting reports.
Reverse Costing® – Structure, Process and Cost Analysis – by
System Plus ConsultingThe Reverse Costing® report developed by System Plus Consulting provides full
teardowns, including detailed photos, precise measurements, material analyses,
manufacturing process flows, supply chain evaluations, manufacturing cost analyses and
selling price estimations. The reports listed below are comparisons of several analyzed
components from System Plus Consulting. More reports are however available, and over
60 reports will be released in 2019.The complete list is available at www.systemplus.fr.
Patent Reports – by KnowMadeMore than describing the status of the IP situation, these analyses provide a missing link
between patented technologies and market, technological and business trends. They offer
an understanding of the competitive landscape and technology developments from a
patent perspective. They include key insights into key IP players, key patents and future
technology trends. For 2019 KnowMade will release over 15 reports.
The markets targeted are :
• Mobile & Consumer
• Automotive & Transportation
• Medical
• Industrial
• Telecom & Infrastructure
• Defense & Aerospace
• Linked reports are dealing with the same topic to provide
• a more detailed analysis.
About Yole Développement | www.yole.fr | ©2019
36
OUR 2019 REPORTS COLLECTION (1/5)18 fields of excellence combined with six markets to provide a complete picture of your industry landscape
MEMS & SENSORS
o MARKET AND TECHNOLOGY REPORT
• Status of the MEMS Industry 2019 - Update
• Status of the Audio Industry 2019 - New
• Uncooled Infrared Imagers and Detectors 2019 – Update
• Consumer Biometrics:Technologies and Market Trends 2018
• MEMS Pressure Sensor Market and Technologies 2018
• Gas & Particle Sensors 2018
o STRUCTURE, PROCESS & COST REPORT
• MEMS & Sensors Comparison 2019
• MEMS Pressure Sensor Comparison 2018
• Particle Sensors Comparison 2019
• Miniaturized Gas Sensors Comparison 2018
o PATENT REPORT
• MEMS Foundry Business Portfolio 2019 - New
• Miniaturized Gas Sensors 2019 - New
PHOTONIC AND OPTOELECTRONICS
o MARKET ANDTECHNOLOGY REPORT
• Silicon Photonics and Photonic Integrated Circuits 2019
• LiDARs for Automotive and Industrial Applications 2019 - Update
o PATENT REPORT
• Silicon Photonics for Data Centers: Optical Transceiver 2019 - New
• LiDAR for Automotive 2018
RF DEVICES AND TECHNOLOGIES
o MARKET ANDTECHNOLOGY REPORT
• RF GaN Market: Applications, Players, Technology,
and Substrates 2019 - Update
• 5G’s Impact on RF Front-End Module and Connectivity
for Cell Phones 2019 – Update
• 5G Impact on Telecom Infrastructure 2019 - New
• Radar and Wireless for Automotive: Market and Technology
Trends 2019 - Update
• Passive & Active Antenna Systems for Telecom
Infrastructure 2019 - New
• RF Standards and Technologies for Connected Objects 2018
o STRUCTURE, PROCESS & COST REPORT
• RF Front-End Module Comparison 2019 - Update
• Automotive Radar RF Chipset Comparison 2018
o PATENT REPORT
• Antenna for 5G Wireless Communications 2019 - New
• RF Front End Modules for Cellphones 2018
• RF Filter for 5G Wireless Communications: Materials and Technologies 2019
• RF GaN 2019 – Patent Landscape Analysis
Update : 2018 version still available About Yole Développement | www.yole.fr | ©2019
37
OUR 2019 REPORTS COLLECTION (2/5)18 fields of excellence combined with six markets to provide a complete picture of your industry landscape
IMAGING
o MARKET AND TECHNOLOGY REPORT
• Status of the CIS Industry 2019: Technology
and Foundry Business - Update
• Imaging for Automotive 2019 - Update
• Neuromorphic Technologies for Sensing 2019 - Update
• Status of the CCM and WLO Industry 2019 – Update
• 3D Imaging & Sensing 2018
• MachineVision for Industry and Automation 2018
• Sensors for Robotic Vehicles 2018
o STRUCTURE, PROCESS & COST REPORT
• Compact Camera Modules Comparison 2019
• CMOS Image Sensors Comparison 2019
o PATENT REPORT
• Facial & Gesture Recognition Technlogies in Mobile Devices 2019 - New
• Apple iPhone X Proximity Sensor & Flood Illuminator 2018
MEDICAL IMAGING AND BIOPHOTONICS
o MARKET ANDTECHNOLOGY REPORT
• X-Ray Detectors for Medical, Industrial
and Security Applications 2019- New
• Microscopy Life Science Cameras: Market and Technology Analysis 2019
• Ultrasound technologies for Medical, Industrial
and Consumer Applications 2018
o PATENT REPORT
• Optical Coherence Tomography Medical Imaging 2018
MICROFLUIDICS
o MARKET ANDTECHNOLOGY REPORT
• Status of the Microfluidics Industry 2019 - Update
• Next Generation Sequencing & DNA Synthesis - Technology,
Consumables Manufacturing and Market Trends 2019 - New
• Organs-on-chips Market and Technology Landscape 2019 - Update
• Point-of-Need Testing Application of Microfluidic Technologies 2018
• Liquid Biopsy: from Isolation to Downstream Applications 2018
• Chinese Microfluidics Industry 2018
o PATENT REPORT
• Microfluidic Manufacturing Technologies 2019 – New
• Nanopore Sequencing 2019 - New
INKJET AND ACCURATE DISPENSING
o MARKET ANDTECHNOLOGY REPORT
• Inkjet Printheads - Dispensing Technologies
& Market Landscape 2019 - Update
• Emerging Printing Technologies
for Microsystem Manufacturing 2019 - New
• Piezoelectric Devices from Bulk to Thin Film 2019 - New
• Inkjet Functional and Additive Manufacturing for Electronics 2018
o STRUCTURE, PROCESS & COST REPORT
• Piezoelectric Materials from Bulk to Thin Film Comparison 2019
Update : 2018 version still available About Yole Développement | www.yole.fr | ©2019
38
OUR 2019 REPORTS COLLECTION (3/5)18 fields of excellence combined with six markets to provide a complete picture of your industry landscape
BIOMEMS & MEDICAL MICROSYSTEMS
o MARKET ANDTECHNOLOGY REPORT
• Medical Wearables: Market & Technology Analysis 2019 - New
• Neurotechnologies and Brain Computer Interface 2018
• BioMEMS & Non-Invasive Sensors: Microsystems for Life Sciences
& Healthcare 2018
o PATENT REPORT
• 3D Cell Printing 2019 - New
• Circulating Tumor Cells Isolation 2019 - New
SOFTWARE AND COMPUTING
o MARKET ANDTECHNOLOGY REPORT
• Artificial Intelligence Computing For Automotive 2019 - New
• Hardware and Software for Artificial Intelligence (AI)
in Consumer Applications 2019 - Update
• Image Signal Processor and Vision Processor Market
and Technology Trends 2019
• xPU (Processing Units) for Cryptocurrency, Blockchain, HPC
and Gaming 2019 – New
• Artificial Intelligence for Medical Imaging 2019 - New
o PATENT REPORT
• Artificial Intelligence for Medical Diagnostics - New
MEMORY
o MARKET AND TECHNOLOGY REPORT
• Status of the Memory Industry 2019 - New
• MRAM Technology and Business 2019 - New
• Emerging NonVolatile Memory 2018
o STRUCTURE, PROCESS & COST REPORT
• Memory Comparison 2019
o PATENT REPORT
• Magnetoresistive Random-Access Memory (MRAM) 2019 - New
• 3D Non-Volatile Memory 2018
ADVANCED PACKAGING
o MARKET ANDTECHNOLOGY REPORT
• Fan Out Packaging Technologies and Market Trends 2019 - Update
• 3D TSV Integration and Monolithic Business Update 2019 - Update
• Advanced RF SiP for Cellphones 2019 - Update
• Status of the Advanced Packaging Industry 2019 - Update
• Status of the Advanced Substrates 2019 - Update
• Panel Level Packaging Trends 2019 - Update
• Automotive Packaging Market & Technology Trends 2019 - New
• Trends in Automotive Packaging 2018
• Thin-Film Integrated Passive Devices 2018
o STRUCTURE, PROCESS & COST REPORT
• Advanced RF SiP for Cellphones Comparison 2019
Update : 2018 version still available About Yole Développement | www.yole.fr | ©2019
39
OUR 2019 REPORTS COLLECTION (4/5)18 fields of excellence combined with six markets to provide a complete picture of your industry landscape
SEMICONDUCTOR MANUFACTURING
o MARKET ANDTECHNOLOGY REPORT
• Nano-Imprint Technology Trends for Semiconductor
Applications 2019 - New
• Equipment and Materials for Fan Out Packaging 2019 - Update
• Equipment for More than Moore: Thin Film Deposition
& Etching 2019 - New
• Wafer Starts for More Than Moore Applications 2018
• Polymeric Materials at Wafer-Level
for Advanced Packaging 2018
• Bonding and Lithography Equipment Market
for More than Moore Devices 2018
o STRUCTURE, PROCESS & COST REPORT
• Wafer Bonding Comparison 2018
o PATENT REPORT
• Hybrid Bonding for 3D Stack 2019 – New
BIOTECHNOLOGIES
o MARKET AND TECHNOLOGY REPORT
• CRISPR-Cas9 Technology: From Lab to Industries 2018
o PATENT REPORT
• Personalized Medicine 2019 – New
SOLID STATE LIGHTING
o MARKET ANDTECHNOLOGY REPORT
• Status of the Solid State Light Source Industry 2019 - New
• Edge Emitting Lasers (EELS) 2019 - New
• Light Shaping Technologies 2019 - New
• Automotive Advanced Front Lighting Systems 2019 - New
• VCSELs – Market and Technology Trends 2019 - Update
• IR LEDs and Laser Diodes – Technology, Applications,
and Industry Trends 2018
• Automotive Lighting 2018: Technology, Industry and Market Trends
• UV LEDs - Technology, Manufacturing and Application Trends 2018
• LiFi: Technology, Industry and Market Trends 2018
o STRUCTURE, PROCESS & COST REPORT
• VCSEL Comparison 2019
o PATENT REPORT
• VCSELs 2018
DISPLAY
o MARKET ANDTECHNOLOGY REPORT
• Next Generation 3D Displays 2019 - New
• Next Generation Human Machine Interaction (HMI)in Displays 2019 - New
• Micro-and Mini-LED Displays 2019 - Update
• Next Generation TV Panels: New Technologies, Features and
Market Impact 2019
• Displays & Optical Vision Systems for VR, AR & MR 2018
o PATENT REPORT
• MicroLED Displays : Intellectual Property Landscape 2018Update : 2018 version still available About Yole Développement | www.yole.fr | ©2019
40
OUR 2019 REPORTS COLLECTION (5/5)18 fields of excellence combined with six markets to provide a complete picture of your industry landscape
POWER ELECTRONICS
o MARKET ANDTECHNOLOGY REPORT
• Power SiC: Materials, Devices and Applications 2019 - Update
• Power Electronics for EV/HEV and e-mobility:
Market, Innovations and Trends 2019 - Update
• Status of the Power Electronics Industry 2019 - Update
• Discrete Power Packaging : Material Market
and Technology Trends 2019 - New
• Status of the Power ICs Industry 2019 - Update
• Status of the Passive Components for the Power Electronics
Industry 2019 - Update
• Status of the Inverter Industry 2019 - Update
• Status of the Power Module Packaging Industry 2019 - Update
• Wireless Charging Market Expectations
and Technology Trends 2018
• Power GaN 2018: Epitaxy, Devices, Applications
and Technology Trends
o STRUCTURE, PROCESS & COST REPORT
• Automotive Power Module Packaging Comparison 2018
• GaN-on-Silicon Transistor Comparison 2019
• SiC Transistor Comparison 2019
o PATENT REPORT
• Power SiC : Materials, Devices and Modules 2019 - New
• Power GaN : Materials, Devices and Modules 2019 – Update
BATTERY & ENERGY MANAGEMENT
o MARKET ANDTECHNOLOGY REPORT
• Status of the Rechargeable Li-ion Battery Industry 2019 - New
• Li-ion Battery Packs for Automotive and Stationary Storage
Applications 2019 - Update
o PATENT REPORT
• Battery Energy Density Increase: Materials
and Emerging Technologies 2019 - New
• Solid-State Batteries 2019 - New
• Status of the Battery Patents 2018
COMPOUND SEMI.
o MARKET ANDTECHNOLOGY REPORT
• Emerging Semiconductor Substrates:
Market & Technology Trends 2019- New
• Status of the Compound Semiconductor Industry 2019 - New
• InP Materials, Devices and Applications 2019 - New
• GaAs Wafer and Epiwafer Market: RF, Photonics,
LED and PV Applications 2018
o PATENT REPORT
• GaN-on-Silicon Substrate: Materials, Devices
and Applications 2019 - Update
Update : 2018 version still available About Yole Développement | www.yole.fr | ©2019
41
OUR 2019 MONITORS COLLECTION (1/2)
Get the most updated overview of your market to monitor your strategy
Yole Développement, System Plus Consulting and KnowMade, all part of the Yole Group of Companies, are launching a collection of 10 monitors in 2019. The monitors aim to
provide updated market, technology and patent data as well dedicated quarterly analyses of the evolution in your industry over the previous 12 months. Furthermore, you can
benefit from direct access to the analyst for an on-demand Q&A and discussion session regarding trend analyses, forecasts and breaking news.
Topics covered will be compact camera modules (CCMs), advanced packaging, compound semiconductors, microfluidics, batteries, RF and memory.
MARKET MONITOR byYole Développement
A FULL PACKAGE:The monitors will provide the evolution of the market in units, wafer area and revenues.They will also offer insights into what is driving the business and a close look at what ishappening will also be covered in it.
The following deliverables will be included in the monitors:
• An Excel database with all historical and forecast data
• A PDF slide deck with graphs and comments/analyses covering the expected
evolutions
o ADVANCED PACKAGING – NEWThis monitor will provide the evolution of the advanced packaging platforms. It willcover Fan-Out Wafer Level Packaging (WLP), Fan-Out Panel Level Packaging (PLP),Wafer-Level Chip Scale Packaging (WLCSP), Flip Chip packaging platforms, and 2.5Dand 3D Through Silicon Via (TSV) integration. Frequency: Quarterly, starting from Q32019
o COMPOUND SEMI. – NEWThis monitor will describe how the compound semiconductor industry is evolving. Itwill offer a close look at GaAs, InP, SiC, GaN and other compounds of interestproviding wafer volumes, revenues, application breakdowns and momentum.Frequency: Quarterly, starting from Q3 2019
o CAMERA MODULE – NEWThis monitor will provide the evolution of the imaging industry, with a close look atimage sensor, camera module, lens and VCM. Volumes, revenues and momentum ofcompanies like Sony, Samsung, Omnivision and OnSemi will thus be analysed.Frequency: Quarterly, starting from Q3 2019
o MEMORY – UPDATEFor the memory industry you can have access to a quaterly monitor, as well as anadditional service, a monthly pricing. Both services can be bought seprately:
• DRAM Service: Including a quarterly monitor and monthly pricing.
• NAND Service: Including a quarterly monitor and monthly pricing.
REVERSETECHNOLOGY MONITOR by System Plus Consulting
o SMARTPHONES – NEWTo stay updated on the latest components, packaging and silicon chip choices of the smartphone makers, System Plus Consulting has created its first Smartphone ReverseTechnology monitor. This year, get access to the packaging and silicon content database of at least 20 different flagship smartphones – more than five per quarter. Starting at thebeginning of 2019, the monitor will include an Excel database report for each phone and a quarterly comparison.
About Yole Développement | www.yole.fr | ©2019
42
OUR 2019 MONITORS COLLECTION (2/2)
Get the most updated overview of your market to monitor your strategy
PATENT MONITOR by KnowMade
A FULL PACKAGE:Starting at the beginning of the year, the KnowMade monitors include the following deliverables:
• An Excel file including the monthly IP database of:
• New patent applications
• Newly granted patents
• Expired or abandoned patents
• Transfer of IP rights through re-assignment and licensing
• Patent litigation and opposition
• Quarterly report including a PDF slide deck with the key facts & figures of thequarter: IP trends over the three last months, with a close look to key IP players andkey patented technologies.
o GaN for Power & RF ElectronicsWafers and epiwafers, GaN-on-SiC, silicon, sapphire or diamond, semiconductordevices such as transistors, and diodes, devices and applications including converters,rectifiers, switches, amplifiers, filters, and Monolothic Microwave Integrated Circuits(MMICs), packaging, modules and systems.
o GaN for Optoelectronics & PhotonicsWafers and epiwafers, GaN-on-sapphire, SiC or silicon; semiconductor devices suchas LEDs and lasers; and applications including lighting, display, visible communication,photonics, packaging, modules and systems.
o Li-ion BatteriesAnodes made of lithium metal, silicon, and lithium titanate (LTO); cathodes made ofLithium Iron Phosphate (LFP), Nickel-Manganese-Cobalt (NMC), Lithium NickelCobalt Aluminium Oxide (NCA), Lithium Nickel Metal Dioxide (LiNiMO2), LithiumMetal Phosphate (LiMPO4), and Lithium Metal Tetroxide (LiMO4); electrolytesincluding liquid, polymer/gel, and solid inorganics; ceramic and other separators;battery cells including thin film/microbattery, flexible, cylindrical and prismatic; andbattery packs and systems.
o Post Li-ion BatteriesBattery technologies including redox-flow batteries, sodium-ion, lithiumsulfur, lithium-air, and magnesium-ion, and their supply chains, including electrodes, electrolytes,battery cells and battery packs/systems.
o Solid-State BatteriesSupply chain including electrodes, battery cells, battery packs/systems andelectrolytes, including polymer, inorganic and inorganic/polymer, inorganic materials,including argyrodites, LIthium Super Ionic CONductor, (LISICONs), Thio-LISICONs,sulfide glasses, oxide glasses, perovskites, anti-perovskites and garnets.
o RF Acoustic Wave FiltersIncluding Surface Acoustic Wave (SAW), Temperature Compensated (TC)- SAW, BulkAcoustic Wave- Free-standing Bulk Acoustic Resonator (BAWFBAR), BAW-Solidly-Mounted Resonator (BAW-SMR), and Packaging.
o RF Power AmplifiersIncluding Low Noise Amplifiers, Doherty Amplifiers, Packaging, and Millimeter-Wavetechnology.
o RF Front-End Modules
o MicrofluidicsFrom components to chips and systems, including all applications.
About Yole Développement | www.yole.fr | ©2019
43
I-MICRONEWS MEDIA
To meet the growing demand for market,
technological and business information,
i-Micronews Media integrates several tools
able to reach each individual contact within its
network.
We will ensure your company benefits from
this
ONL INE ONS ITE INPERSON
i-Micronews e-newsletter
i-Micronews.com
FreeFullPDF.com
Events Webcasts
Unique, cost-effective ways
to reach global audiences.
Online display advertising
campaigns are great strategies
for improving your
product/brand visibility. They
are also an efficient way to
adapt with the demands of the
times and to evolve an effective
marketing plan and strategy.
Brand visibility, networking
opportunities
Today's technology makes it
easy for us to communicate
regularly, quickly, and
inexpensively – but when
understanding each other is
critical, there is no substitute
for meeting in-person. Events
are the best way to exchange
ideas with your customers,
partners, prospects while
increasing your brand/product
visibility.
Targeted audience
involvement equals clear,
concise perception of your
company’s message.
Webcasts are a smart,
innovative way of
communicating to a wider
targeted audience. Webcasts
create very useful, dynamic
reference material for
attendees and also for
absentees, thanks to the
recording technology.
#15,800+ monthly unique visitors
on i-Micronews.com
#10,900+ weekly readers
of i-Micronews e-newsletter
#110 attendees on average
#7+ key events planned for 2019
on different topics
#380 registrants per webcast on
average to gain new leads for
your business
Contact: Camille Veyrier ([email protected]), Marketing & Communication Director
About Yole Développement | www.yole.fr | ©2019
44
CONTACT INFORMATION
o CONSULTING AND SPECIFIC ANALYSIS, REPORT BUSINESS
• North America:
• Steve LaFerriere, Senior Sales Director for Western US & Canada
Email: [email protected] – + 1 310 600-8267
• Chris Youman, Senior Sales Director for Eastern US & Canada
Email: [email protected] – +1 919 607 9839
• Japan & Rest of Asia:
• Takashi Onozawa, General Manager, Asia Business Development
(India & ROA)
Email: [email protected] - +81 34405-9204
• Miho Ohtake, Account Manager (Japan)
Email: [email protected] - +81 3 4405 9204
• Itsuyo Oshiba, Account Manager (Japan & Singapore)
Email: [email protected] - +81-80-3577-3042
• Korea: Peter Ok, Business Development Director
Email: [email protected] - +82 10 4089 0233
• Greater China: Mavis Wang, Director of Greater China Business
Development
Email: [email protected] - +886 979 336 809
• Europe: Lizzie Levenez, EMEA Business Development Manager
Email: [email protected] - +49 15 123 544 182
• RoW: Jean-Christophe Eloy, CEO & President, Yole Développement
Email [email protected] - +33 4 72 83 01 80
o FINANCIAL SERVICES (in partnership with Woodside Capital
Partners)
• Jean-Christophe Eloy, CEO & President
Email: [email protected] - +33 4 72 83 01 80
• Ivan Donaldson, VP of Financial Market Development
Email: [email protected] - +1 208 850 3914
o CUSTOM PROJECT SERVICES
• Jérome Azémar, Technical Project Development Director
Email: [email protected] - +33 6 27 68 69 33
o GENERAL
• Camille Veyrier, Director, Marketing & Communication
Email: [email protected] - +33 472 83 01 01
• Sandrine Leroy, Director, Public Relations
Email: [email protected] - +33 4 72 83 01 89 / +33 6 33 11 61 55
• Email: [email protected] - +33 4 72 83 01 80
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About Yole Développement | www.yole.fr | ©2019