organic process research and development

1
Fundamentals of Material and Energy Balances (Chapters 2 and 3) and Flow Sheeting (Chapter 4)} attempts to de® ne and explain the fundamental tools used in process design. In general, the author succeeds in this objective and, although somewhat pedestrian in nature, all the necessary foundations are properly and effectively put in place. The second section comprising the next ® ve chapters {Piping and Instrumentation (Chapter 5), Costing and Project Evaluation (Chapter 6), Materials of Construction (Chapter 7), Design Information and Data (Chapter 8) and Safety and Loss Prevention (Chapter 9)} build on the previous section. In an attempt to cover such a wide range of material, the author does little more at times than guide the reader to seek information in the more specialist texts. However, the chapters on Materials of Construction and Design Information and Data are very well conceived and should become obligatory reading for all undergraduates undertaking a design project. The ® nal section of the book comprising Chapters 10 to 13 {Equipment Selection, Speci® cation and Design (Chapter 10), Separation columns (Chapter 11), Heat Transfer Equipment (Chapter 12) and Mechanical Design of Process Equipment (Chapter 13)} is the heart of the book, covering some 350 pages. Chapter 10 details the uses and range of applications of many different types of equipment including outline design procedures. This approach is complemented by reference to more comprehensive texts when appropriate. The speci- ® cation and design of distillation and absorption columns is covered in Chapter 11. Starting with a brief review of the fundamental phenomena,the author outlinesappropriate distillation design methods in suf® cient detail to clearly point the way for a competent student. The coverage of absorption columns is disappointing with little reference to equipment design either under non-isothermal operation or for systems involving absorption with reaction. Chapter 12 is a student guide to the design of heat transfer equipment. It is well written with the clearly explained design methodology appropriately supported by worked examples. The design procedures are easy to follow and all the necessary complementary texts are properly cited. Chapter 13 is concerned with the mechanical design of equipment and contains some well written guidance to the design of pressure vessels and brief discussions of the design of storage tanks, centrifuges and heat exchanger tube sheets. Chapter 14 (General Site Considerations) is rather disappointing in both scope and context and the author’s coverage of an Environmental Impact Assessment is very super® cial. Overall, the latest addition to the Coulson and Richardson Volume 6 is an improvement on the previous version and will undoubtedly be widely used by undergraduates to support their work on the design projects. C. A. Millington University of Surrey Journal Review Organic Process Research and Development Organic Process Research and Development was launched as a new journal earlier this year. It is jointly published by the American Chemical Society and The Royal Society of Chemistry and is aimed at chemists (and their chemical engineering colleagues) working in process R & D. I looked at issue number 2 (March/April 1997). The journal contained 7 articles and 6 shorter `technical notes’ as well as an extensive technical review of heterogeneous catalysis in ® ne chemicals manufacture. In addition, there was a useful review of the current literature elsewhere in this area by the editor, along with correspon- dence and book reviews. The content of the journal related predominantly to the pharmaceutical and ® ne chemical industry, with approximately one half of the submissions falling into the former category. It contained much complex organic chemistry with detailed considerations of molecular and crystal structure of compounds, although the emphasis was on development of the reaction conditions and scale-up rather than the study of the chemical mechanisms in their own right. It also contained some papers which could be categorized as process engineering, including discussions of reactor geometry and agitation conditions for scale up of a co-polymerization reaction and a study of batch crystal- lization operating strategy. There was also a description of laboratory equipment for undertaking multiple hydrogena- tion reactions, an example of the considerable interest in heterogeneous catalytic processes in the journal. It was pleasing to see so many contributors from industry in the issue reviewed. It is not easy to get industrialists to submit articles to journals as the subject editors of the Transactions will testify! However, the reasons that lie behind this traditional reluctance (con® dentiality, etc.) may mean that such articles may not be completely up-to-date or already have been published elsewhere (e.g. patents). Nevertheless, this is a welcome feature and it will be interesting to see if the number and quality of contributions from that quarter can be maintained in the future. Chemical engineers are being constantly encouraged to become more involved in the early, laboratory stages of process development. For those employed in the pharma- ceutical and ® ne chemicals industries this publication should make interesting reading, for while this is a primarily a journal for the development chemist, its breadth of subject matter means that it contains something to appeal to their engineering colleagues as well. Launching a new journal is a considerable challenge at any time but particularly so in the current climateÐ I wish them well! Alan Hall Zeneca, Hudders® eld 524 BOOK REVIEW Trans IChemE, Vol 75, Part A, July 1997

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Page 1: Organic Process Research and Development

Fundamentals of Material and Energy Balances (Chapters 2and 3) and Flow Sheeting (Chapter 4)} attempts to de® neand explain the fundamental tools used in process design.In general, the author succeeds in this objective and,although somewhat pedestrian in nature, all the necessaryfoundations are properly and effectively put in place.

The second section comprising the next ® ve chapters{Piping and Instrumentation (Chapter 5), Costing andProject Evaluation (Chapter 6), Materials of Construction(Chapter 7), Design Information and Data (Chapter 8) andSafety and Loss Prevention (Chapter 9)} build on theprevious section. In an attempt to cover such a wide range ofmaterial, the author does little more at times than guide thereader to seek information in the more specialist texts.However, the chapters on Materials of Construction andDesign Information and Data are very well conceived andshould become obligatory reading for all undergraduatesundertaking a design project.

The ® nal section of the book comprising Chapters 10to 13 {Equipment Selection, Speci® cation and Design(Chapter 10), Separation columns (Chapter 11), HeatTransfer Equipment (Chapter 12) and Mechanical Designof Process Equipment (Chapter 13)} is the heart of the book,covering some 350 pages.

Chapter 10 details the uses and range of applications ofmany different types of equipment including outline designprocedures. This approach is complemented by reference tomore comprehensive texts when appropriate. The speci-® cation and design of distillation and absorption columnsis covered in Chapter 11. Starting with a brief review ofthe fundamental phenomena, the author outlines appropriatedistillation design methods in suf® cient detail to clearlypoint the way for a competent student. The coverage ofabsorption columns is disappointing with little reference toequipment design either under non-isothermal operation orfor systems involving absorption with reaction.

Chapter 12 is a student guide to the design of heat transferequipment. It is well written with the clearly explaineddesign methodology appropriately supported by workedexamples. The design procedures are easy to follow and allthe necessary complementary texts are properly cited.Chapter 13 is concerned with the mechanical design ofequipment and contains some well written guidance to thedesign of pressure vessels and brief discussions of thedesign of storage tanks, centrifuges and heat exchanger tubesheets. Chapter 14 (General Site Considerations) is ratherdisappointing in both scope and context and the author’ scoverage of an Environmental Impact Assessment is verysuper® cial.

Overall, the latest addition to the Coulson and RichardsonVolume 6 is an improvement on the previous version andwill undoubtedly be widely used by undergraduates tosupport their work on the design projects.

C. A. MillingtonUniversity of Surrey

Journal Review

Organic Process Research and Development

Organic Process Research and Development was launchedas a new journal earlier this year. It is jointly published bythe American Chemical Society and The Royal Society ofChemistry and is aimed at chemists (and their chemicalengineering colleagues) working in process R & D. I lookedat issue number 2 (March/April 1997).

The journal contained 7 articles and 6 shorter `technicalnotes’ as well as an extensive technical review ofheterogeneous catalysis in ® ne chemicals manufacture. Inaddition, there was a useful review of the current literatureelsewhere in this area by the editor, along with correspon-dence and book reviews. The content of the journal relatedpredominantly to the pharmaceutical and ® ne chemicalindustry, with approximately one half of the submissionsfalling into the former category. It contained much complexorganic chemistry with detailed considerations of molecularand crystal structure of compounds, although the emphasiswas on development of the reaction conditions and scale-uprather than the study of the chemical mechanisms in theirown right. It also contained some papers which could becategorized as process engineering, including discussions ofreactor geometry and agitation conditions for scale up of aco-polymerization reaction and a study of batch crystal-lization operating strategy. There was also a description oflaboratory equipment for undertaking multiple hydrogena-tion reactions, an example of the considerable interest inheterogeneous catalytic processes in the journal.

It was pleasing to see so many contributors from industryin the issue reviewed. It is not easy to get industrialists tosubmit articles to journals as the subject editors of theTransactions will testify! However, the reasons that liebehind this traditional reluctance (con® dentiality, etc.) maymean that such articles may not be completely up-to-date oralready have been published elsewhere (e.g. patents).Nevertheless, this is a welcome feature and it will beinteresting to see if the number and quality of contributionsfrom that quarter can be maintained in the future.

Chemical engineers are being constantly encouraged tobecome more involved in the early, laboratory stages ofprocess development. For those employed in the pharma-ceutical and ® ne chemicals industries this publicationshould make interesting reading, for while this is a primarilya journal for the development chemist, its breadth of subjectmatter means that it contains something to appeal to theirengineering colleagues as well.

Launching a new journal is a considerable challenge atany time but particularly so in the current climateÐ I wishthem well!

Alan HallZeneca, Hudders® eld

524 BOOK REVIEW

Trans IChemE, Vol 75, Part A, July 1997