organ printing - texas tech university health sciences center · organ printing: a computer-aided,...

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Organ printing: A computer-aided, layer-by-layer additive biofabrication of 3D functional human tissue and organ constructs using self-assembling tissue spheroids as building blocks. Tissue fusion Tissue maturation Biofabrication of a vascular tree Microsphere as bioink Biopaper 3D tissue fabrication process

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Page 1: Organ printing - Texas Tech University Health Sciences Center · Organ printing: A computer-aided, layer-by-layer additive biofabrication of 3D functional human tissue and organ constructs

Organ printing:A computer-aided, layer-by-layer additive biofabrication of 3D

functional human tissue and organ constructs using self-assembling

tissue spheroids as building blocks.

Tissue fusion Tissue maturationBiofabrication of a vascular tree

Microsphere

as bioink

Biopaper

3D tissue fabrication process

Page 2: Organ printing - Texas Tech University Health Sciences Center · Organ printing: A computer-aided, layer-by-layer additive biofabrication of 3D functional human tissue and organ constructs

3D bioprinting

techniques

Orifice-based

printing

Orifice-free

printing

Inkjet-based printing

Filament-based printing

Laser-based printing

Page 3: Organ printing - Texas Tech University Health Sciences Center · Organ printing: A computer-aided, layer-by-layer additive biofabrication of 3D functional human tissue and organ constructs

3D cellular

tube being

printed

Z-shape platform

attached to Z

stage

Container

with

CaCl2

α

LED strobe Camera

Moving

direction

Dispense head

attached to XY stages

Bioink (3T3

cell

suspension

and NaAlg)

D

H

t

OXY

Z

CaCl2 solution level

Cells

Page 4: Organ printing - Texas Tech University Health Sciences Center · Organ printing: A computer-aided, layer-by-layer additive biofabrication of 3D functional human tissue and organ constructs

Fig. (a) Printed tube and (b) tube surface and (c) cell viability test after liquefying

(a)

Cell

(b)

Live Cell

Dead Cell

After liquefying

(c)

Page 5: Organ printing - Texas Tech University Health Sciences Center · Organ printing: A computer-aided, layer-by-layer additive biofabrication of 3D functional human tissue and organ constructs

[Murphy2014]

Page 6: Organ printing - Texas Tech University Health Sciences Center · Organ printing: A computer-aided, layer-by-layer additive biofabrication of 3D functional human tissue and organ constructs

[Hockaday2012]

Page 7: Organ printing - Texas Tech University Health Sciences Center · Organ printing: A computer-aided, layer-by-layer additive biofabrication of 3D functional human tissue and organ constructs

[Murphy2014] [Brown2010]

Page 8: Organ printing - Texas Tech University Health Sciences Center · Organ printing: A computer-aided, layer-by-layer additive biofabrication of 3D functional human tissue and organ constructs

[Koch2012]

Page 9: Organ printing - Texas Tech University Health Sciences Center · Organ printing: A computer-aided, layer-by-layer additive biofabrication of 3D functional human tissue and organ constructs

[Miller2012]

3D lattice of filaments

Page 10: Organ printing - Texas Tech University Health Sciences Center · Organ printing: A computer-aided, layer-by-layer additive biofabrication of 3D functional human tissue and organ constructs

References