opportunities in biomedical data science · opportunities in biomedical data science karl broman...
TRANSCRIPT
Opportunities inbiomedical data science
Karl Broman
Biostatistics & Medical Informatics, UW–Madison
kbroman.orggithub.com/kbroman
@kwbromanSlides: bit.ly/carleton2019
Biomedical data explosion
▶ Electronic health records (EHR)▶ Imaging▶ Genome/proteome/metabolome/microbiome data▶ Personal activity/health tracking devices
2
Biomedical data explosion
▶ Electronic health records (EHR)▶ Imaging▶ Genome/proteome/metabolome/microbiome data▶ Personal activity/health tracking devices▶ High-throughput measurements in agriculture and ecology
2
3
Intercross
P1 P2
F1 F1
F2
5
Genome scan
0
2
4
6
8
Chromosome
LOD
sco
re
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 X
BB BR RR
0.80.91.01.1
6
Genome scan
0
2
4
6
8
Chromosome
LOD
sco
re
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 X
6
High-throughput phenotypes
7
High-throughput phenotypesislet
QTL position (cM)
Pro
be p
ositi
on (
cM)
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 X
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7
Multi-parent crossesG0
A B C D E F G H
G1
G2
G10
G15
G20
8
The work
▶ Collaboration▶ Data exploration▶ Methods development▶ Software development
– R– C++– Coffeescript– Ruby
9
The work
▶ Collaboration▶ Data exploration▶ Methods development▶ Software development
– R– C++– Coffeescript– Ruby
9
Qiongshi LuHuman genome-wide association studies
10
Sündüz KeleşFunctional mediation analysis
11
Christina KendziorskiClock genes in stem cells
12
Tony GitterPathways disrupted by cancer
13
Vikas SinghAnalysis of brain images
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Biomedical data science PhD at UW-Madison
▶ Faculty spanning biostatistics, bioinformatics, and computer science▶ Broad opportunities for scientific collaborations▶ Flexible course requirements▶ Research rotations▶ Literature and professional skills seminars
bit.ly/MadBDS
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Slides: bit.ly/carleton2019
kbroman.org
github.com/kbroman
@kwbroman
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