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The integrated ecosystem of today’s ophthalmic practice

Cassini Presentation - COMPANY CONFIDENTIAL – April 2016

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Growing the premium cataract channel

2015: Toric IOLs accounted for 3.7% of all IOLs Implanted Worldwide1

… it could be 50%2

1 Source: MarketScope report 2015 2 Source: Hill Distribution Data. Provided courtesey of Dr. Warren Hill

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Integrated ecosystem in cataract surgery:Seamless interaction between clinic and OR

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Pre Op Diagnostics &IOL selection

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Post Op Analysis &SIA management

PatientRefractive Outcome

SurgeonResults & Efficiency

Femto enabled AI’s

Guidance &verification

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Cassini integrated technology makes our partners more successful

Erik-Jan WorstCEO & President, Ophtec

“The combined offering of Cassini with Ophtec’s Precizon Toric IOL has allowed us to grow our market share and help our customers with a total astigmatism management solution"

Denise ViscoEyes of York, York, PA

“The addition of Cassini and Streamline has provided such great, predictable outcomes that I use arcuate incisions on most of my patients with less than 1.7D. This improves efficiency, reduces costs and increases conversion of patients to the premium channel”

Cassini Total Corneal AstigmatismGPS-like data from anterior & posterior cornea

Multi-colored LED point-to-point ray tracing

2nd Purkinje point-to-point ray tracing technology

• Retrospective chart review• 35 consecutive cases with toric IOL

implant• Preoperative measurements

oCassini TCA based toric IOL axis and power selection

• Postoperative residual refractive astigmatism

Cassini Outcome StudyDr. Elizabeth Yeu, Virginia Eye Consultants

Astigmatism Correction with Cassini TCAPre-Op Total Corneal Astigmatism 95% Limits of

agreementn = 35

Astigmatism Correction with Cassini TCAPost-Op Residual Astigmatism 95% Limits of

agreementn = 35

Cassini TCA v ORA – published data

ORA - Hatch et al JRS 2015

< 0.5Dn = 37

50%

75%

100%

94.2%

82.1%78.0%

Lenstar + Barrett

Nomogram < 0.5Dn = 28

Cassini TCA < 0.5Dn = 35

• Physician owned ASCs treat about 1000 pts/ year1

• High-volume centers have about 20% conversion to toric IOL 200 patients

• Total cost of enhancement is about $2,000.00– Tangibles and intangibles

1 Source: MarketScope report 2013; 2 Source: Hatch et al. Journal of Refractive Surgery April 2015; 3 Based on assumed enhancement costs $2.000 per patient; 4 Retrospective study from Elizabeth Yeu – Cassini data on file

IOL selection with ORA2

• 78% within 0.5D RRA

• 44 Patients > 0.5D RRA

• Potential enhancement cost $ 88,000.003

IOL selection with Cassini TCA4

• 94% within 0.5D RRA

• Only 12 patients > 0.5D RRA

• Potential enhancement cost $ 24,000.003

Economics of getting it right

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