ontents - australian centre for nanomedicine (acn) annual report 20… · 1 about the acn 3...
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Contents
1 About the ACN
3 Directors’ Report
5 At a Glance
7 Research
8 2016 New Grant Funding
10 2016 New Research Projects
14 High Impact Papers
15 Engagement
16 Media
19 Events
20 Presentation
25 Collaborating Organisations
26 Awards, Prizes and Achievements
28 Governance, Our People & Visitors
29 Steering Committee
30 Organisational Chart
31 ACN Staff and Students
33 Visitors to the ACN
34 Publications
42 Cover Gallery
43 Financial Report
About the ACN
The ACN was established in mid-2011 as a national innovator in NanoMedicine, bringing together a diverse team of
leading researchers in Medicine, Science and Engineering to deliver the next generation of health innovations, and is
dedicated to providing new solutions for therapeutics and diagnostics enabled by nanotechnology.
The key science that underpins all the activities of the Centre is to fully understand and exploit the unique properties of
nanomaterials for various applications (eg. Contrast agents for cell imaging and therapeutics for treating cancer). The
Centre’s strategic vision is to create teams focused on particular diseases using Team ACN’s skills in drug delivery,
diagnostics and imaging.
To succeed in this, it requires an integrated team of researchers coming from diverse backgrounds and we have
assembled a remarkable team of highly distinguished scientists and engineers covering nanotechnology, polymer science,
cancer biology, chemical engineering, microfluidic, chemistry, sensors and imaging, social science and experimental arts
(3D imaging) from five UNSW faculties: Medicine, Science, Engineering, Arts & Social Sciences, and Arts and Design.
Dr Friederike Mansfeld, Senior Research Officer at Children's Cancer Institute
1
Dr. Robert Utama setting up a RAFT polymerization reaction with PhD student Kelly Zong.
2
Directors’ Report
Scientia Professor
Justin Gooding
Professor Maria Kavallaris
Professor Cyrille Boyer
2016 marks the 3rd year of
implementation of the Centre’s
2nd strategic plan of 5 years. We
have grown from the initial 40+
research team from the inception
of the Centre to today’s 120 strong
team spread across five UNSW
faculties, encompassing a huge
amount of activities. We hope this
report gives a flavour of the
achievements we have made in
2016.
The past twelve months has seen
outstanding scientific output,
significant capacity building, the
growth of National and
International collaboration,
leadership in organising and
leading significant research
conference and workshops,
numerous prizes, awards and
fellowships, together with a strong
media profile to communicate our
purpose and successes.
Some areas we would like to
highlight are:
• Research productivity was
extremely impressive in 2016
including high-impact papers in
chemistry, polymer science and
medicine, with increasing focus on
cross-disciplinary output across the
Centre. In 2016, we have over 113
publications, 7 book chapters and 3
patents with a growing number of
papers published from the Centre’s
collaborative research programs.
We published 14 papers with
impact factors above 10 in the
following prestigious journals:
Chemical Reviews, Chemical
Society Reviews, Nano Letters,
Nature Nanotechnology, Science,
Advanced Drug Delivery Reviews,
Journal of the American Chemical
Society, Angewandte Chemie and
Advanced Materials.
• Significant amount of
grant funding for collaborative
research. Total new grant funding
for ACN members reached a record
high of $17M. Including NHMRC
Program Grant APP1091261 2016-
2020 $7M+ awarded to Professors
Kavallaris, Gooding, et al. The aim
of the Program Grants scheme is to
provide support for teams of high
calibre researchers to pursue
broad based, multi-disciplinary and
collaborative research addressing
complex problems.
• Leadership and
participation in the organisation of
major conferences and meetings
including the 7th International
Nanomedicine Conference, held in
Coogee on 27-29 June, where ACN
researchers contributed many
lectures. The Biomedical Futures
workshop organised by Associate
Professor Matthew Kearnes in
December 2016 brought together
primary care networks, clinicians,
care professionals, ACN
researchers, and healthcare
administrators, to co-design major
public events in NSW, Victoria and
Queensland on precision medicine.
• Numerous high profile
awards and fellowships. ARC
Laureate Fellow and Scientia
Professor Justin Gooding was
elected Fellow of the Australian
Academy of Science. Professor
Maria Kavallaris was awarded the
NHMRC Principal Research
Fellowship and inducted as a
Fellow of the Australian Academy
of Health and Medical Sciences
(AAHMS). Cyrille Boyer won the
ACS Biomacromolecules/
Macromolecules Award and was
awarded the LeFevre Memorial
Prize by the Australian Academy of
Science. It was also great
recognition that Cyrille was
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promoted to Professor. Dr Jason
Xu from Professor Cyrille Boyer’s
group was awarded the prestigious
ARC Future Fellowship. It is not
possible to list all the awards and
prizes in this highlight section,
more awards are listed in the main
body of the report, clearly
indicating significant outside
recognition of the quality of
research being performed by ACN
researchers.
• ACN researchers have
demonstrated significant
interactions with the media; at the
forefront has been Professor Justin
Gooding and team with numerous
interviews and press releases
relating to “A Paper Based Sensor
for Monitor Sun Exposure”. There
was also great media coverage of
Phoebe Phillips, Joshua McCarroll,
Cyrille Boyer, Maria Kavallaris’
journal paper “New cancer
nanomedicine reduces pancreatic
tumour growth”. Media reached
over 3 million people in Australia
alone.
• Our Centre researchers
gave over 40 plenary, keynote or
invited talks at major international
conferences. Many of these talks
were fully or partially financially
supported.
• It is tremendous that we
are actively hosting a large number
of domestic and overseas visits to
set up collaboration. Eminent
visitors to the Centre include
Professor George Whitesides from
Harvard University and Professor
Vince Rotello from University of
Massachusetts Amherst.
• ACN is attracting
increasing numbers of young
talents to our research team. In
2016 alone, 9 fresh talents joined
the team including Associate
Professor John McGhee, whose
research explores arts-led modes
of visualising complex scientific
and biomedical data using the 3D
CGI techniques.
In Summary, 2016 has seen our
Centre going from strength to
strength. We commend to you this
report on our activities and events
and we look forward to reporting
on more exciting research and
successes in the future.
Justin Gooding
Centre Co-Director
Maria Kavallaris
Centre Co-Director
Cyrille Boyer Centre Co-Director
Dr Parisa Sowti Khiabani wearing a UV-sensitive skin patch developed by the Gooding Group
4
At a Glance
Our People
Research Output
18 Members incl 10 Self-Funded
Fellows
4 Associate Members
7 Self-Funded Research Fellows
15 PostDocs 73 Honours and
PhD Students
8 Administration and Technical
Staff
113 Journal Publications, 7 book chaptors and 3 patents
14 journal publications with impact factors >10
Over $17M new funding to fund 30+ projects
commencing in 2016
47 collaborating organisations, including 3
from China, 5 from USA, 12 from Europe and 27 from Australia & New Zealand
17 interdisciplinary research projects
Over 40 Plenary, Keynote and Invited talks at major
international conferences, many with financial support
36 visitors (including 22 international) visited ACN for
collaboration
15 memberships on Editorial Boards
Numerous awards, prizes and honours, including Eureka
Prize finalist and 2 Fellowships
Approx. 40 seminars, oral presentations and poster
presentations at universities, symposiums and meetings
Over 80 media articles (including TV & Radio) both
in Australia and overseas
ACN hosted 7th International NanoMedicine Conference
where many ACN researchers contributed lectures
5
Professor Cyrille Boyer and his PhD student Sivaprakash Shanmugam grinding spinach leaves to extract
chlorophyll (from plants) to make photosensitive functional polymers.
6
Research
7
2016 New Grant Funding
Total new funding for ACN members’ research has reached a record level of over $17M in 2016.
Below is a list of ACN funding highlights.
NHMRC Program Grant, APP1091261,
Kavallaris, Gooding, et al. Precision
nanomedicine-based diagnostics and
therapeutics for refractory
malignancies. (2016-2020).
$7,088,520
Cancer Council Program Grant, PG16-
01, Kavallaris et al. Improving
outcomes for children with leukaemia
through molecular targeted
therapies. (2016-2020). $2,249,946
NHMRC Project Grant, APP1100202,
Elizabeth Hinde, et al. Regulation of
ERK driven cell proliferation by the
actin cytoskeleton. (2016-2019).
$920,972
NSW Smart Sensing Network, Justin
Gooding, William Donald. Public
sector grant. (2016-). $900,000
ARC LIEF Projects, LE160100168,
Justin Gooding, Cyrille Boyer, Pall
Thordarson, et al. Facility for
Characterisation of BioNanomaterials
(2016-). $650,000
NHMRC-ARC Dementia Research
Development Fellowship, Adam
Martin. Self-assembled hydrogels as a
model for neurodegeneration (2016-
2019). $594,644
NHMRC Project Grant, APP1104461,
Elizabeth Hinde, et al. The role of
nuclear architecture in the DNA
Damage Response. (2016-2018).
$561,966
ARC LIEF Projects, LE160100033,
Cyrille Boyer, et al. Equipment for
Advanced Surface Analysis. (2016).
$500,000
NHMRC Equipment Grant
(APP9000322): Live cell TIRF
microscope for HILO applications.
Gaus K, Kavallaris M, Phillips P, et al.
(2016). $390,000
Cancer Council NSW project grant,
Phoebe Phillips, Joshua McCarroll,
Cyrille Boyer, et al. Reprogramming
the tumour microenvironment by
therapeutically targeting heat shock
proteins in pancreatic cancer.(2016-).
$360,000
Cancer Institute NSW Equipment
Grant: ‘High throughput five laser
flow cytometer’. Phillips P, et al.
(2016). $339,500
ARC Linkage Projects, LP160100979,
Katharina Gaus. Modulating T cell
responses with novel Lck activating
compounds. (2016-2019). $335,000
ARC Linkage Projects, LP160100575,
Pall Thordarson, Richard Tilley, et al.
Precision luminescent solar
concentrators from robust quantum
dot arrays. (2016-2019). $330,378
NHMRC Equipment Grant – awarded
as part of the UNSW Major Research
Equipment and Infrastructure
Initiative Scheme (MREII): ‘3D Printed
Scape Microscope’. Phillips P, et al.
(2016). $300,000
ARC Discovery Projects,
DP160102681, William Donald.
Rapid, ultra-sensitive protein
structure elucidation by mass
spectrometry. (2016-2018). $299,700
ARC Linkage Projects, LP160100573,
Pall Thordarson, et al. Scaling
manufacture of three-dimensional
microstructures for the medical
devices industry. (2016-2019).
$228,186
Cancer Institute NSW Career Development Fellowship, Joshua McCarroll. Nanomedicine-based treatment for lung cancer.(2016-). $150,000 Cancer Council Program Grant , RG 16-08, Phoebel Phillips, et al. Reprogramming the tumour microenvironment by therapeutically targeting heat shock proteins in pancreatic cancer. $120,000
The Kids Cancer Project, Maria
Kavallaris. Stathmin regulation of
microRNA expression in
neuroblastoma cells. (2016-2017).
$115,173
UNSW MREII, Cyrille Boyer, et al.
Thermal and near ir spectrometers
for material analysis and surface
characterisation. (2016-). $105,000
Ferronova Pty Ltd; Justin Gooding,
Richard Tilley. Industry grant. (2016-
2018). $102,500
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Ross Foundation Grant, Joshua
McCarroll. Nanomedicine-based
treatment to inhibit medulloblastoma
growth.(2016). $100,000
Innovation Grant, Avner Pancreatic
Cancer Foundation: ‘Elucidating the
mechanism by which mutY-homolog
knockdown kills pancreatic cancer
cells. Phillips P, et al. (2016).
$100,000
Steadfast Foundation Grant, Joshua
McCarroll. Nanoparticles carrying
RNA-based therapies to treat
medulloblastoma. (2016-). $50,000
NHMRC Gold Star, Phoebe Phillips,
Cyrille Boyer, Joshua McCarroll, et al.
Reprogramming the tumour micro-
environment by therapeutically
targeting heat shock proteins in
pancreatic cancer. (2016-). $50,000
Ettason Pty Ltd; Pall Thordarson.
Industry grant. (2016-). $50,000
UNSW Goldstar Research Grant:
‘Reprogramming the tumour
microenvironment by therapeutically
targeting heat shock proteins in
pancreatic cancer’. Phillips P,
McCarroll J, et al. (2016). $40,000
Australia-India Council (AIC) Board
grant, Cyrille Boyer, Edgar Wong.
Disinfecting Indian Waters with Novel
Antimicrobial Polymer Membranes.
(2016). $19,000
CCIA SPOT Award, Orazio Vittorio. Targeting copper homeostasis in neuroblastoma. (2016). $12,000
AINSE Award, Orazio Vittorio.
[64Cu]CuCl2 PET imaging to
investigate the effect of Dextran-
Catechin on copper metabolism in
neuroblastoma. (2016). $9,000
Clockwerk Pty Ltd; Pall Thordarson.
Industry grant. (2016). $7,500
RR Medsciences Pty Ltd; Pall
Thordarson. Industry grant. (2016).
$5,000
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2016 New Research Projects
Nanomedicine-Based Treatment for
Lung Cancer
Dr Joshua McCarroll, Prof Maria
Kavallaris, Prof Tom Davis, A/Prof
Phoebe Phillips
This new project will use
nanoparticles to package and deliver
RNA-based drugs to silence the
expression of key genes in lung
cancer cells which regulate tumour
growth, metastases and
chemotherapy drug resistance. This
project involves collaboration with
chemists at the Australian Centre for
NanoMedicine, UNSW and Monash
University as well as cancer biologists
at the Children’s Cancer Institute and
UNSW Australia. This study has the
potential to produce a new class of
nanomedicines which inhibit lung
cancer growth and improve patient
survival.
The Use of Nanoparticles for the
Treatment of Pancreatic Cancer
A/Prof Phoebe Phillips, Dr Joshua
McCarroll, Prof Maria Kavallaris, Prof
Tom Davis, Prof Cyrille Boyer
Pancreatic cancer is the 4th
leading
cause of cancer death in the world. It
is predicted to be number 2 by 2030.
This project will use star
nanoparticles developed by our team
to deliver siRNA to pancreatic cancer
cells to silence the expression of
genes which promote aggressive
tumour growth. To examine the
therapeutic potential of our novel
nanomedicines we will use mouse
models which closely mimic the
clinical setting. This project has great
potential to generate a new class of
therapeutic drugs which inhibit
pancreatic cancer growth and
improve the survival and quality of
life for patients.
Development of Nanomedicines for
the Treatment of Medulloblastoma
Dr Joshua McCarroll, Prof Maria
Kavallaris, Prof Tom Davis, Ms Helen
Forgham
Medulloblastoma is the most
common form of childhood brain
cancer. Despite an improvement in 5
year survival patients often suffer
from long-term off-target toxicity
from the treatments which has a
negative impact on their quality of
life. This multidisciplinary project
involves chemists from the Australian
Centre for NanoMedicine and
Monash university as well as cancer
biologists from the Children’s Cancer
Institute to develop novel
nanoparticles as delivery vehicles for
therapeutic drugs to treat
medulloblastoma.
[64
Cu]CuCl2 PET Imaging Revealed
that a Natural Derived Compound
Dextran-Catechin Mediates Its
Anticancer Activity by
Downregulating Copper Metabolism
in Neuroblastoma
A. Parmar , O. Vittorio, A. Charil, M.
Brandl, K. Kimpton, G. Cirillo, M.
Kavallaris, G. Pascali
Neuroblastoma is a very aggressive
cancer with high mortality rate in
children. Our group studies the
effects of a novel treatment based on
a Dextran-Catechin conjugate on
animal models of neuroblastoma;
survival and behavioural results have
demonstrated the efficacy of this
treatment.
We have found evidence that the
mechanism of action of this drug is
linked to intracellular copper (Cu)
trafficking and distribution. Our aim
was therefore to employ [64
Cu]CuCl2 to
monitor Cu distribution in-vivo in
neuroblastoma xenograft mouse
models, both with and without
treatment.
A pilot study will be carried out in
normal healthy female BALB/c‐Fox1nu/
Ausb mice (n=4, 6-8 weeks of age) to
understand the clearance of [64
Cu] over
2 days. For these pilots, 7-10MBq of
[64
Cu]CuCl2 in 100 µL will be injected via
lateral tail vein and imaged at time
points 0-2 h, 5 h, 24 h and 48 h (Inveon
PET/CT scanner). The human
neuroblastoma BE(2)-C xenograft
mouse model used for the study will be
obtained by injecting 2X106 human
neuroblastoma cells subcutaneously
into female BALB/ c‐Fox1nu/Ausb mice
(6-8 weeks of age).
When the tumours size reach to 0.3 to
0.5 cm, typically after 12 days, the mice
will be divided in to two groups: 1)
saline treated 2) dextran-catechin
treated; PET/CT scans were performed
on both groups.
On the day of imaging, either saline
(100 µL) or dextran-catechin (300 µg in
100 µL of saline) will be injected in the
mice 1 h prior to PET scan, and then
anaesthesia will be performed using 2%
isoflurane. 7-10MBq of [64
Cu]CuCl2 will
be injected via lateral tail vein,
followed by PET/CT imaging at 0-2 h, 5
h, 24 h and 48 h post radiotracer
injection.
After the imaging session, mice will be
sacrificed and tissues collected for in
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vitro analysis. This opens the way to a
deeper understanding of the
molecular basis of dextran-catechin
treatment and its potential
applicability to other type of cancers
depending on copper.
Stathmin Regulation of Microrna
Expression in Neuroblastoma Cells
Maria Kavallaris, et al.
Neuroblastoma, the most common
solid tumour of young children,
frequently presents with aggressive
metastatic disease and for these
children the 5-year survival rates are
dismal.
Recently, research by the Kavallaris’
group and funded by The Kids’ Cancer
Project has shown that a protein
called stathmin mediates
neuroblastoma metastasis. Thanks to
continuation of funding by TKCP, the
project will focus on understanding
the role that specific DNA sequences
play in regulating metastasis and
potentially develop new targeted
therapies.
Disinfecting Indian Waters with
Novel Antimicrobial Polymer
Membranes
Cyrille Boyer, Edgar Wong
Cyrille Boyer & Edgar Wong will be
collaborating with IITD materials
scientist, Leena Nebhani, to develop
new and effective water purification
membranes that can kill multidrug-
resistant bacteria found in Indian
waters. Clean and safe water supply
is essential for preventing the spread
of infectious diseases caused by
bacteria. In India, clean water supply
remains inadequate and this has led
to bacteria-causing diseases such as
bloody diarrhoea or dysentery.
Furthermore, the rise of antibiotic
resistance means there is an
increased urgency in developing novel
and effective materials to combat this
global issue. By using advanced
polymer engineering, this project will
provide effective nanomaterials that
can safeguard our health from 'bad
bugs'.
Regulation of ERK Driven Cell
Proliferation by the Actin
Cytoskeleton
Dr Elizabeth Hinde, Prof Peter
Gunning, et al.
The cells in your body respond to
external signals and control their
proliferation by transmitting signals
from one part of the cell to another.
This has usually been thought to
involve the movement of signals
through a liquid medium without the
involvement of any machinery to
control the movement. The project
aims to test the role of the
architecture of the cells in physically
moving a growth signal from one
place to another. We think that the
architecture involved plays a key role
in cancer.
The Role of Nuclear Architecture in
the DNA Damage Response
Dr Elizabeth Hinde, et al.
The goal of the proposed research is
to understand how dynamic changes
to the chromatin genome packaging
network, interact with the DNA
damage response and gene
expression machinery, to repair
damaged DNA and the impact this has
on cancer biology. To do so we are
combining cutting edge molecular
biology techniques with innovative
novel microscopy methods developed
by our research team, that far exceed
the spatiotemporal resolution currently
used to study chromatin biology.
Precision Nanomedicine-Based
Diagnostics and Therapeutics for
Refractory Malignancies
Prof Maria Kavallaris, Prof Justin
Gooding, Prof Richard Lock, Prof Tom
Davis
The vast majority of cancer patients die
of their disease due to the emergence
of drug resistant cancer cells or
metastatic disease that is diagnosed at
late stages. Our program aims to
develop new types of therapy to
specifically target aggressive cancers.
To detect cancer early and evaluate the
effectiveness of cancer therapy, we will
develop sensitive diagnostic tools and
devices. This research has application
to both childhood and adult cancers.
Self-Assembled Hydrogels as a Model
for Neurodegeneration
Dr Adam Martin NHMRC-ARC
Dementia Research Development
Fellowship
Alzheimer’s disease (AD) is a
neurodegenerative disease which
currently affects over 340,000
Australians. Often, symptoms of AD are
not apparent until the disease is well
advanced, limiting chances of
successful treatment. In this project,
hydrogels made from biocompatible
peptides will be used to grow neural
cell culture models to study the
development of the disease in its early
stages. This will help to develop new
diagnostic tools for the early detection
of AD.
Scaling Manufacture of Three-
Dimensional Microstructures for the
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Medical Devices Industry
ARC Linkage Projects
Pall Thordarson, et al.
This project aims to transform
microscale three-dimensional
prototyping into a cheap high volume
manufacturing process through a
novel soft embossing process.
Although three-dimensional printing
has been hailed as a disruptive
technology, because it can print
complex shapes directly from
drawings, it is too slow at microscale
for high volume manufacture. This
research will develop microdevices
for painless collection of blood, its
analysis, and drug delivery. Cost-
effective manufacture of these
microdevices is expected to tap into
the large medical devices industry,
leading to establishing new
businesses in the point-of-care and
drug delivery markets.
Precision Luminescent Solar
Concentrators from Robust Quantum
Dot Arrays
ARC Linkage Projects
Pall Thordarson, Richard Tilley, et al.
This project aims to make
luminescent solar concentrators that
can harness solar energy from
surfaces not suited for conventional
solar cells, such as car windows. It will
design, synthesise and conduct
detailed energy transfer studies of
robust inorganic quantum dot arrays
with fit-for-purpose precise spectral
properties. Synthetic light-harvesting
dye arrays have often been proposed
to solve bottleneck challenges in the
solar energy sector but there are
issues with stability, processing and
their photophysical output matching
market needs. This project’s dyes are
expected to create market
opportunities for Australian
luminescent solar concentrator
technology.
Modulating T Cell Responses with
Novel Lck Activating Compounds
ARC Linkage Projects
Katharina Gaus, et al.
This project aims to research T cell
receptor (TCR) signal initiation and
network plasticity and identify uses
for drugs that affect the kinase Lck.
The TCR signalling network has
considerable plasticity so that
modulation of one molecule (here the
drug target is Lck) can have non-linear
effects on T cell function. This project
intends to use novel drugs to
understand how the T cell network
can be exploited to control both the
magnitude and quality of the T cell
responses. This research is expected
to aid the design of immune-
modulating drugs.
Rapid, Ultra-Sensitive Protein
Structure Elucidation by Mass
Spectrometry
ARC Discovery Projects
William Donald
This project seeks to develop a
method for rapidly discovering classes
of molecules that bind to unique sites
on proteins. The development of new
pharmaceuticals is frequently delayed
by the time and resources required to
identify the sites that new chemical
entities bind to protein targets. A
recent discovery has resulted in the
ability to completely characterise
large protein sequences directly from
single mass spectra. This project aims
to leverage this breakthrough by
developing a rapid new approach for
revealing ligand-protein binding sites
using whole-protein mass
spectrometry. This would enable novel
sites of interactions between molecules
and protein targets to be discovered
rapidly with high sensitivity. In turn,
this would allow the efficient design of
next-generation classes of bioactive
molecules.
Equipment for Advanced Surface
Analysis
ARC LIEF Projects
Cyrille Boyer, et al.
This project aims to establish
equipment for advanced surface
analysis to provide Australian
researchers with cutting-edge
capabilities in surface science. Vital
chemical and physical reactions often
occur at surfaces. Understanding these
reactions requires analysis of the
composition and electronic structure of
the surface and near-surface regions.
Neutral impact collision ion scattering
spectroscopy and inverse
photoemission spectroscopy measure
concentration depth profiles and
electronic structure. The depth
resolution of the profiles is in the order
of the distance between two
neighbouring atoms in a solid or liquid
and is the best currently achievable.
The equipment providing these
capabilities is expected to support
research with applications in
photovoltaics, catalysis, colloid surfaces
and interfaces, coatings and
nanocomposites.
Facility for Characterisation of
BioNanomaterials
Justin Gooding, Cyrille Boyer, Pall
Thordarson, et al.
The facility for characterisation of
bionanomaterials aims to provide
researchers with access to an
integrated facility for advanced
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characterisation of nanomaterials
from inception to application in
biomedicine. Nanotechnology has
contributed to significant advances
across a range of disciplines and is
increasingly used in biomedical
applications. The facility aims to allow
detailed examination of how
nanomaterials interact in biological
systems; from individual
nanoparticles to whole animals, and
through developing this fundamental
understanding provide the means to
produce new and highly effective
nanomaterials for biomedical
applications. The facility plans to
support programs using
nanomaterials for molecular imaging
and intelligent drug delivery, while
developing greater understanding of
how to create more effective
nanobiomaterials.
Elucidating the Mechanism by which
MutY-Homolog Knockdown Kills
Pancreatic Cancer Cells
Phoebe Phillips, et al.
Pancreatic cancer is a deadly disease
that urgently requires better
treatments. A/Prof Phillips, Dr
Sharbeen, and their team have
identified a protein that, when
inhibited, can kill pancreatic cancer
cells and decrease their resistance to
cancer drugs. This project will identify
the mechanism(s) behind these effects.
This information will help translate
their target into the clinic.
New Way to Target Pancreatic Cancer and Prevent Tumour Growth
015
A/Prof Phoebe Phillips is exploring a new way to target pancreatic cancer – by reducing the scar tissue around the tumour. This would improve the delivery of drugs to the cancer and prevent further growth. The research is a result of collaboration with Professor Cyrille Boyer as well as Professor Maria Kavallaris and Dr Joshua McCarroll. Published in the journal Biomacromolecules, the article generated immense media interest both in Australia and overseas.
13
High Impact Papers
The Centre continued its great research and publication record in 2016. Our team of
researchers published 113 journal articles, 14 of which have impact factors over 10.
Below is a list of Articles with Impact Factors >10
C. Boyer, N. Corrigan, K. Jung, D.
Nguyen, T. Nguyen, N. Adnan, S.
Oliver, S. Shanmugam, J. Yeow,
2016, Bioapplications of Copper
Mediated Living Radical
Polymerization Atom Transfer
Radical Polymerization & Copper
Mediated Polymerization,
Chemical Reviews, 116, 1803-1949
[IF 38.5]
J. M. Ren, T. G. McKenzie, Q. Fu, E.
H. H. Wong, J. Xu, Z. An, S.
Shanmugam, T. P. Davis, C. Boyer
and G. G. Qiao, 2016, Star Polymers,
Chemical Reviews, 116 (12), 6743-
6836. [IF 37.369]
N. Corrigan, S. Shanmugam, J. Xu,
C. Boyer, 2016, Photoredox
Catalysis in Organic and Polymer
Synthesis, Chemical Society
Reviews, 45, 6165-6212, [IF 35.4]
Hinde E; Thammasiraphop K; Duong
HTT; Yeow J; Karagoz B; Boyer C;
Gooding JJ; Gaus, 2016, Pair
correlation microscopy reveals the
role of nanoparticle shape in
intracellular transport and site of
drug release, Nature
Nanotechnology. (In Press) [IF
35.267]
S. Shanmugam, C. Boyer, 2016,
Organocatalyzed polymerization
driven by solar energy, Science,
352 (6289), 1053-1054. [IF 33.5]
K. A. Gilmore, M. W. Lampley, C.
Boyer, E. Harth, 2016, Matrices for
combined delivery of proteins and
synthetic molecules, Advanced Drug
Delivery Reviews, 98, 77-85. [IF15.0]
A. Andres-Arroyo, B. Gupta, F.
Wang, J. J. Gooding and P. J. Reece,
2016, Optical Manipulation and
Spectroscopy of Silicon
Nanoparticles Exhibiting Dielectric
Resonances, Nano Letters, 16(3),
1903-1910. [IF 13.779]
Zhang L; Vogel YB; Noble BB;
Gonçales VR; Darwish N; Brun AL;
Gooding JJ; Wallace GG; Coote ML;
Ciampi S, 2016, TEMPO Monolayers
on Si(100) Electrodes: Electrostatic
Effects by the Electrolyte and
Semiconductor Space-Charge on
the Electroactivity of a Persistent
Radical, Journal of the American
Chemical Society, 138(30), 9611–
9619. [IF 13.038]
J. Xu, S. Shanmugam, C. Fu, K. F.
Aguey-Zinsou, C. Boyer, 2016,
Selective Photo-Activation: From
Single Unit Monomer Insertion
Reaction to Controlled Polymer
Architectures, Journal of the
American Chemical Society, 138
(9), 3094–3106. [IF 13.0]
J. J. Gooding and K. Gaus, 2016,
Single-Molecule Sensors: Challenges
and Opportunities for Quantitative
Analysis, Angewandte Chemie -
International Edition, 55(38), 11354-
11366 [IF 11.709]
J. Xu, C. Fu, S. Shanmugam, C. J.
Hawker, G. Moad, C. Boyer, 2016,
Synthesis of Discrete Oligomers by
Sequential PET-RAFT Single-Unit
Monomer Insertion. Angewandte
Chemie International Edition,
December 2016. [IF 11.7]
S. Shanmugam, J. Xu, C Boyer,
2016, Light‐Regulated
Polymerization under Near‐
Infrared/Far‐Red Irradiation
Catalyzed by Bacteriochlorophyll a.
Angewandte Chemie International
Edition, 55, 3, 1036-1040 [IF 11.5]
J.J. Gooding, 2016, Single Entity
Electrochemistry progresses to cell
counting, Angew. Chem. Int. Ed. 55
(42), 12956-12958. [IF >10]
Y.H. Zheng, C. Jiang, S.H. Ng, Y. Lu, F.
Han, U. Bach, J.J. Gooding, 2016,
Unclonable plasmonic security
labels achieved by shadow-mask-
lithography assisted self-assembly,
Adv. Mater. 28 2330-2336. [IF >10]
14
Engagement
15
Media
The ACN researchers are dedicated to reaching out beyond the scientific community and have
engaged in various television, radio, newspaper, magazine and online interviews; and contributed
to newspaper articles and online blogs to promote the Centre and its research. The following list
provides a glimpse of the Centre’s extensive media engagement.
A/Prof John McGhee, “Virtual
reality explores drug delivery to
breast cancer cells”.
Related media coverage:
- SBS, Virtual reality gives patients a
room with a view, 11/10/2016
- Australian Financial Review,
Virtual reality to spread beyond
games to change the way we live,
8/9/2016
- The Age, Virtual reality trip inside
cancer cells can help design better
chemotherapy drugs, 16/8/2016
- Sydney Morning Herald, Virtual
reality trip inside cancer cells can
help design better chemotherapy
drugs, 16/8/2016
- WIRED, 'Edible' robots and
batteries you can swallow could
finally help cure cancer, 23/8/2016
- Mashable Australia, Virtual reality
allows scientists to walk into a
cancer cell,16/8/2016
- UNSW Newsroom, Virtual reality
explores drug delivery to breast
cancer cells,16/8/2016
- New Scientist, Virtual reality lets
you stroll around a breast cancer
cell, 1/7/2016
- The Australian, Nano cell project:
art meets science to make the
invisible visible, 31/8/2016
- ABC Fantastic Journey , 16/8/2016
- ABC Midday News, 16/8/2016
P.S. Khiabani, A.H. Soeriyadi, P.J.
Reece, J.J. Gooding, A Paper Based
Sensor for Monitor Sun Exposure,
ACS Sensors 1 775-780 (2016).
Related media coverage:
- ACS Sensors, Monitoring sun
exposure with a portable paper
sensor, 25/5/2016
- Science Daily, Monitoring sun
exposure with a portable paper
sensor, 25/5/2016
- Electronics, Portable Paper-Sensor
Device Helps Monitor Sun
Exposure, 25/5/2016
- Health Medicine Network,
Monitoring sun exposure with a
portable paper sensor, 25/5/2016
- Controlled Environments
Magazine, Portable Paper Sensor
Monitors Sunburn Risk, 25/5/2016
- Engineering and Technology
Magazine, 27/5/2016
- MD Linx, A paper-thin idea for a
sunburn sensor, 27/5/2016
- Trend Hunter, Color-Changing
Sunburn Sensors, 30/5/2016
- Innovation Toranto, Monitoring
sun exposure with a portable
paper sensor, 25/5/2016
- iPR Newswire, Paper UV Sensor
Can Monitor Sun Exposure —
Market Talk, 25/5/2016
- UPI, Paper-based sensor may help
people avoid overexposure to sun,
26/5/2016
- Science News Line, Monitoring Sun
Exposure with a Portable Paper
Sensor, 25/5/2016
- Abomas, Monitoring sun exposure
with a portable paper sensor,
26/5/2016
- New Atlas, Treated paper warns
users of impending sunburn,
25/5/2016
- Phys Org, Monitoring sun
exposure with a portable paper
sensor, 25/5/2016
- Check The Science, Monitoring sun
exposure with a portable paper
sensor, 26/5/2016
- AZO Sensors, Researchers Develop
Portable, Paper-Based Sensor for
Monitoring Sun Exposure,
26/5/2016
- JDW Insured, Monitoring sun
exposure with a portable paper
sensor
- The Economist, Avoiding Sunburn,
Patched Up, 4/6/2016
- Science Meets Business, Portable
paper sun sensor, 7/6/2016
- UNSW Newsroom, Sunburn sensor
among top techs at nanomedicine
conference, 21/6/2016
- ABC Radio, New waterproof patch
could alert users to excessive sun
exposure, 22/6/2016
- Channel 7, New patch provides an
'early warning' against sunburn,
22/6/2016
- KABC-TV Channel 7, Los Angeles.
16
E. Hinde, K. Thammasiraphop,
H.T.T. Duong, J. Yeow, B.
Karagoza, C. Boyer, J.J. Gooding,
K. Gaus, Pair-correlation
microscopy reveals the role of
nanoparticle shape in intracellular
transport and site of drug release,
Nature Nanotech. (In press)
Related media coverage:
- Science Daily , Journey to the
centre of the cell: Nano-rods and
worms wriggle best, 12/9/2016
- COMPAMED, Journey to the
center of the cell: Nano-rods and
worms wriggle best, 13/9/2016
- Nano Today, The long and the
short of it: Nanoparticle shape
matters to cells, 1/12/2016
- Life Biotechnology, Nano rod and
worm are the best shaped
nanoparticles in cancer drug
delivery, 16/9/2016
- Asian Scientist, Nanoparticles
Shaped Like Rods & Worms Enter
Cell Nucleus More Easily,
22/9/2016
- The Australian, ‘Hotrods’ prove the
best vehicle for nanotech delivery,
29/9/2016
Dr Declan Kuch, Medium website,
Health Data Futures: Prediction,
Platforms, Populations,
20/10/2016
Pasquier E, André N, Street J,
Chougule A, Rekhi B, Ghosh J,
Philip DS, Meurer M, MacKenzie
KL, Kavallaris M, Banavali SD.
2016, 'Effective Management of
Advanced Angiosarcoma by the
Synergistic Combination of
Propranolol and Vinblastine-based
Metronomic Chemotherapy: A
Bench to Bedside Study',
EBioMedicine, vol. 6, pp. 87 – 95.
Related Media Coverage:
- Australian Life Scientist, Blood
pressure drug boosts the effect of
chemo, 3/10/2016.
Dr Majid E Warkiani, collaborative
work with MIT on “Electric Field
Cancer Therapy”.
Related Media Coverage:
- MIT News, New microfluidic device
offers means for studying electric
field cancer therapy, July 5 2016.
- Digital Trends, A coin-sized device
could have big effect on treating
cancer with electric fields, July 6
2016.
- Science Daily, New microfluidic
device offers means for studying
electric field cancer therapy, July 6
2016.
Nguyen TK; Duong HT T;
Selvanayagam R; Boyer C; Barraud
N, 2015, 'Iron oxide nanoparticle-
mediated hyperthermia stimulates
dispersal in bacterial biofilms and
enhances antibiotic efficacy',
Scientific Reports, vol. 5
Related Media Coverage:
- Phys.org, Nanotech weapon
against chronic bacterial infections
in hospitals, 18/12/2015
- Nanotechnology Now,
Nanotechnology Now - Press
Release: Nanotech weapon against
chronic bacterial infections in
hospitals, 18/12/2015
- Health Medicinet, Australian
researchers develop new
technique to combat chronic
bacterial infections in hospitals,
18/12/2015
- Infection Control Today, Scientists
Develop Nanotech Weapon
Against Chronic Bacterial
Infections, 18/12/2015
- Scicasts, Researchers Develop New
Technique to Combat Chronic
Bacterial Infections in Hospitals
- R&D, Nanotech weapon against
chronic bacterial infections in
hospitals, 18/12/2015
- Medindia, Nanoparticles Used To
Fight Chronic Bacterial Infections
In Hospitals, 18/12/2015
- Medical News Today, Nanotech
weapon against chronic bacterial
infections in hospitals, 18/12/2015
- Gizmag Emerging Technology
Magazine, Scientists use
nanoparticles to attack chronic
bacterial infections, 18/12/2015
- KurzweilAI, Magnetic
nanoparticles combat biofilms, a
source of chronic bacterial
infections, 21/12/2015
- Mariela Cabrera, Iron oxide
nanoparticle-mediated
hyperthermia stimulates dispersal
in bacterial biofilms and enhances
antibiotic efficacy, 23/12/2015
17
Teo J, McCarroll JA, Boyer, C,
Youkhana J, Sagnella SM, Duong
HT, Liu J, Sharbeen G, Goldstein D,
Davis TP, Kavallaris M, Phillips PA.
A rationally optimized nanoparticle
system for the delivery of RNA
interference therapeutics into
pancreatic tumors in vivo.
Biomacromolecules,17,2337-51
(2016).
Related media coverage:
- Daily Telegraph, "Scientists
deserve a gold medal".
- Adelaide Advertiser, "Medical
triumph in war on cancer".
- Daily Telegraph, "Aussies unlock
secret of world's deadliest cancer",
08 Aug 2016
- UNSW Newsroom, "New cancer
nanomedicine reduces pancreatic
tumour growth".
- ABC Newcastle Radio Interview
with Paul Bevan, "Bevan says
researchers from UNSW have
made a breakthrough in the
treatment of Pancreatic Cancer".
- Radio 2UE, "Interview with Dr
Phoebe Phillips, Head, UNSW
Pancreatic Cancer Translational
Research Group, to discuss her
group's breakthrough in the battle
against pancreatic cancer".
- Invited article for the Last Post.
"New cancer nanomedicine
reduces pancreatic tumour
growth".
- Research Australia's website. "New
cancer nanomedicine overcomes
drug delivery barrier in pancreatic
cancer".
- Invited article for Inspire
Magazine.
- TV Channel 9, "Australian medical
researchers are on the verge of a
breakthrough that could
dramatically reduce deaths from
pancreatic cancer".
- Radio 2GB, Alan Jones, "Jones says
Sydney scientists have achieved a
breakthrough in the battle against
pancreatic cancer".
- Cure Cancer Australia's website,
"Unlocking the Potential to Treat
Pancreatic Cancer".
- Medical Republic magazine, "The
age of programmable cancer
drugs", 5th October 2016
- TV Channel 9, "An Australian team
has developed a new drug and a
way to getting pancreatic cancer
through to tumours"
- TV Channel 7, Mark Ferguson,
"UNSW scientists have achieved a
breakthrough in the battle against
pancreatic cancer".
- TV Channel 9, Peter Overton,
"UNSW scientists have achieved a
breakthrough in the battle against
pancreatic cancer".
- Radio Channel 9, Eva Milic, "UNSW
scientists have achieved a
breakthrough in the battle against
pancreatic cancer".
- Radio 96 FM, "Scientists from
UNSW have invented a technology
which can be used to combat
pancreatic cancer".
- TV NBN Lismore, "After 16 years of
work, Dr Phoebe Phillips and her
team at UNSW has developed a
new drug for fighting pancreatic
cancer".
- Channel 9 Expert Opinion,
"Australian scientists are one step
closer to winning the fight against
pancreatic cancer which claims
five Australian lives a day".
- TV Channel 9, Today Show, Lisa
Wilkinson, "Scientists in Sydney
are claiming a breakthrough in the
battle against pancreatic cancer".
- The Western Weekender
Newspaper, 'Positive Signs for New
Cancer Drug'.
- TV NBN Godford, "Five Australians
die from pancreatic cancer every
day. Doctor Phoebe Phillips and
her team at UNSW have
developed a new drug and a way
of getting it through to the
tumours".
- The Medical Republic, The age of
programmable cancer drugs,
5/10/2016.
18
Events
7th International Nanomedicine Conference
The 7th International Nanomedicine Conference, hosted by the ACN and the CBNS, took place at the Crowne
Plaza, Coogee Beach from 27-29 June 2016. This is a key event in the nanomedicine research community and
was attended by biologists, clinicians, chemists, material chemists and engineers from around the world.
36 ACN members, post-doctoral researchers, and PhD students presented their research at the Conference,
including 11 oral presentations and 25 posters. Congratulations go to 3 of our PhD students Ms Kristel Tjandra,
Mr Manish Sriram and Mr Alistair Laos for receiving poster competition prizes. Special thanks go to our
conference Support Committee team leaders Dr Robert Utama, Mr Manish Sriram, Mr Vincent Tan and our
wonderful team of volunteers who helped make the event successful.
Professor George Whitesides from
Harvard University gave a plenary talk at
the Conference. “Simple/Low-cost
Bioanalysis for the Developing World
and Point of Care”.
Professors Justin Gooding & Maria
Kavallaris (co-chairs) welcoming
plenary speaker Professor Vincent
Rotello from University of
Massachusetts.
The 3D Imaging workshop at the
Conference attracted great interest
among cancer researchers.
Mr Vincent Tan, PhD student from the Gooding group presented his research at the conference, “Polymeric hydrogel used as an extracellular matrix mimic for 3D cell culturing”.
Mr Walter Muskovic, PhD student from the Kavallaris group discussing research with a fellow Conference delegate.
Dr David Chang, PhD student from the
Kavallaris group studying posters
during poster session.
19
Presentations
The Centre puts great value on the knowledge shared and gained at conferences both
local and international. The following is a list of selected talks, seminars and poster
presentations in 2016.
Plenary Presentations
– Conferences and
Symposia
J.J. Gooding, “Single Entity Sensors:
From Detecting Many to Detecting
One to Detecting Many” Biosensors
Symposium 2016, Melbourne, 30th
November 2016 (Financially
Supported)
J.J. Gooding, Cell based measurement
tools to explore therapeutic action ,
Emerging Therapeutics Summit
(ETS’16) Melbourne, Australia 23 – 25
Nov 2016 (Financially supported)
J.J. Gooding, S.G. Parker, Y. Yang, S.
Ciampi, K. Chuah, Y.F. Wu, Single
Entity Electrochemistry: An
Electroanalytical Perspective,
Electrochem2016, Royal Society of
Chemistry, Leicester, 17-19 Aug, 2016.
(Fully financially supported)
J.J. Gooding, L.M.H. Lai, I.Y. Goon, K.
Chuah, E. Murago, R. Tavallaie, D.B.
Hibbert, Magnetic Nanoparticles As
Dispersible Electrodes, ElecNano7,
Lille, France, 23-25 May 2016.
(Financially supported)
M. Kavallaris, “Next Big Thing:
Nanotechnology in Cancer Therapy”,
South Australian committee of the
Australian Society for Medical
Research (ASMR), State Scientific
Meeting, Adelaide, 8-Jun-16
M. Kavallaris, “Targeting Cancer-
Associated Genes Using Nanoparticle
Delivery of Gene Silencing”, Emerging
Therapeutics Summit 2016,
Melbourne, 23-25 Nov 2016
M. Kavallaris, “Gene silencing in solid
tumours: opportunities and
challenges”, Nanomedicine: Prospects
for a Brighter Future in Healthcare,
Mauritius, 01-04 Aug 2016
ME Warkiani, Microfluidic Platforms
for Cancer Diagnosis. 2nd Nastran
International Cancer Symposium,
September 28-29, 2016, Mashhad,
Iran.
Keynote Talks –
Conferences and
Symposia
J.J. Gooding, From understanding cell-
material interactions to 3D printing of
cells, Advanced Manufacturing
Summit 2016, Sydney, Australia, 14-15
Nov 2016 (Financially supported)
R.H. Utama, L. Atapattu, C. Fife, A.
O’Mahony, J. Ribeiro, M. Kavallaris, J.J.
Gooding, The 3D Printing of Cells, 17th
International Biotechnology
Symposium and Exhibition,
Melbourne, Australia, 24-27 Oct 2016.
(Financially supported)
X. Lu, X.Y. Cheng, T. Tabarin, P.R.
Nicovich, K. Gaus, J.J. Gooding,
Towards Single Molecule Biosensors
using super-resolution microscopy,
26th Anniversary World Congress on
Biosensors, Gothenburg, Sweden, 25-
27 May 2016. (Financially supported)
M.H. Choudhury, S. Ciampi, S.G.
Parker, Y. Yang, R. Tavallaie, L. Zarei,
V.R. Goncales, J.J. Gooding, Light
Activated Electrochemistry: A strategy
for performing voltammetry on a
monolithic surface where you want,
when you want with micron scale
spatial resolution, 19th Topical
Meeting of the International Society
of Electrochemistry, Auckland, New
Zealand, 17-20 April 2016. (Financially
supported)
J.J. Gooding, Interdisciplinary
Research involving Chemistry, Physics,
Biology, Mathematics and
Engineering: Why I need your help?,
Science Teachers Association New
South Wales, Annual Conference,
University of New South Wales,
Sydney, 19-20 February 2016.
(Financially supported)
M. Kavallaris, "Leadership
effectiveness & influencing Culture",
The Women in STEM Leadership
Summit, Sydney, 23-24 Aug 2016
M. Kavallaris, "Targeting Aggressive
Cancers with Nanoparticle Delivery or
RNAi" 1st International Society for
Nanomedicine Congress, Korea
University, Seoul, Korea, 28 -30 Sep
2016
M. Kavallaris, “New Therapies for
Cancer” Nuclear Sciences &
Technologies for Health III: A New
Paradigm for Molecular Imaging,
Charles Perkins Centre, University of
Sydney, 14-Nov-16
Invited Talks –
Conferences and
Symposia
20
J.J. Gooding, Nanotechnology and
Biosensors: From Detecting Small
Molecules and Drugs to the
Monitoring of the Activity of Whole
Cells, Workshop on Advances in
Biotechnology for Food & Medical
Applications, Sydney University,
Sydney, 5-7 Oct 2016.
E. Hinde, K. Thammasiraphop, H.T.T.
Duong, J. Yeow, B. Karagoza, C. Boyer,
J.J. Gooding, K. Gaus, Pair-correlation
microscopy reveals the role of
nanoparticle shape in intracellular
transport and site of drug release,
Warwick Polymer Conference 2016,
Warwick UK, 11-14 July 2016.
(Financially supported)
J.J. Gooding, K. Chuah, E. Murago, R.
Tavallaie, S.M. Silva, D.B. Hibbert,
Magnetic Nanoparticles As Dispersible
Electrodes, 251st American Chemical
Society National Meeting, San Diego,
13-17 March 2016.
J.J. Gooding, L.M.H. Lai, I.Y. Goon, K.
Chuah, E. Murago, R. Tavallaie, D.B.
Hibbert, Magnetic Nanoparticles As
Dispersible Electrodes, Pittcon 2016,
Atlanta, 6-10 March 2016. (Financially
supported)
M.H. Choudhury, S. Ciampi, Y. Yang, V.
Gonçales, M.B. Kashi, J.J. Gooding,
Switching electrochemistry on and off
at monolayer modified silicon
electrodes using light, Centre for
Electrochemistry, Annual Workshop
on Electrochemistry, Austin, Texas,
USA, 13-14 February 2016. (Financially
supported)
J.J. Gooding, Next Generation
Biosensors: From Detecting Many to
Detecting One to Detecting Many, ACS
on Campus, University of Hyderabad,
India, 29 Jan 2016 (Fully financially
supported)
J.J. Gooding, Next Generation
Biosensors: From Detecting Many to
Detecting One to Detecting Many, ACS
on Campus, Indian Institute of
Technology Bombay, India 25 Jan 2016
(Fully financially supported)
M. Kavallaris, “Cancer: Microtubules,
drug resistance and
nanotherapeutics”, John Curtin School
of Medical Research, Canberra, 4 Nov
2016.
M. Kavallaris, “Designing Polymer
Therapeutics for the Treatment of
Childhood Cancer” 11th International
Symposium on Polymer Therapeutics
(ISPT), Centro de Investigación
Príncipe Felipe, Valencia, Spain, 23-25
May 2016
M. Kavallaris, "Nanoparticle Delivery
to 3D Cell & Animal Models” First
Summer School of International
Society for Nanomedicine, Seoul
National University Hospital, Seoul,
Korea, 26 – 28 Sep 2016
M. Kavallaris, “Cancer, Microtubules
& Nanomedicine” Houston Methodist
Research Institute, Houston USA, 15
Apr 2016
M. Kavallaris, “Delivery Systems for
Cancer Therapy – Why do we need
them” Drug Delivery Australia
Conference 2016 – Particles to People,
Sydney, 27-28 Oct 2016
M. Kavallaris, Australasian
Pharmaceutical Science Association
(APSA) Annual Scientific Meeting,
“Precision medicine, personalising
healthcare”, Sydney, 2-5 Dec 2016
O. Vittorio, "Dextran-Catechin
conjugate: Targeting copper
metabolism in neuroblastoma”.
Chemistry, Physics and
Nanotechnology, University of
Technology Sydney, Sydney 20th May
2016.
O. Vittorio, “Dextran-Catechin
conjugate: Targeting copper
metabolism in neuroblastoma”. The
Kids Research Institute, The Children’s
Hospital at Westmead, Sydney, 25
May 2016
C Boyer, "Photoredoxcatalysts; An
efficient Tool for Modern Polymer
Synthesis", MACRO 2016, Istanbul,
Turkey, 17-21 July 2016.
C Boyer, “Functional nanomaterials”,
ACS Conference: American Chemical
Society Philadelphia, 20-25th August,
2016. (All Expenses Paid)
C Boyer, “CO and NO Releasing
Polymers as Antimicrobial Agents”,
ACS Conference: American Chemical
Society Philadelphia, 20-25th August,
2016. (All Expenses Paid)
C Boyer, “Light responsive materials
for controlled delivery”, Zing
Conference Polymer Chemistry,
Ireland, 5-9 August 2016. (Partially
Funded)
C Boyer, “Photoredox chemistry for
polymer synthesis”, World Living
Polymerization, Budapest, 29 May – 3
June 2016. (Partially Funded)
C Boyer, Selective photocatalysis: A
new tool for polymer chemists.
Emerging Polymer Technologies
Summit, Melbourne, Australia, 14 – 16
September 2016.
J McCarroll, The role of microtubule
proteins in regulating tumour growth
and chemoresistance. 8th Annual
Garvan Cell Signalling Symposium,
Oct, 2016, Sydney, Australia.
J McCarroll, Developing RNA-based
therapies for the treatment of cancer.
Drug Delivery Australia Conference,
Oct, 2016, Sydney, Australia.
ME Warkiani, The emerging role of
inertial microfluidics in high
throughput cell sorting. ACS Annual
Conference, Oct 30 – Nov 2, 2016,
Sydney, Australia
J McCarroll, Beatson Institute, “The
role of microtubules in regulating lung
21
cancer growth and chemoresistance”,
Glasgow, Scotland, 6th
July 2016
Phillips PA. Targeting the tumour stroma for the treatment of pancreatic cancer. Beatson International Cancer Conference, Glasgow, UK. July, 2016. (All travel expenses paid)
M.E. Warkiani, 1st National Microfluidic Conference, March 5-6, 2016, Tehran, Iran
Zi (Sophia) Gu, Biocompatible
layered double hydroxide
nanoparticles for targeted drug
delivery and bio-imaging, 7th
International Nanomedicine
Conference, Sydney 27-29 June
2016.
Seminars – Universities
and Societies
M. Kavallaris, “Microtubules: Multiple
Functions in Cancer Drug Resistance,
Tumourigenesis and Metastasis”,
Centro de Investigaciones Biologicas,
Madrid University, Madrid, Spain, 20
May 2016
M. Kavallaris, “Cancer, Microtubules
and Nanotherapeutics”, Centre de
Recherche en Oncologie biologique et
Oncopharmacologie, INSERM,
University of Marseille, 17 May 2016
J McCarroll, Co-Convenor for Kids
Cancer Alliance “Emerging
Technology” workshop Dec 9, 2016.
O Vittorio. “Dextran-Catechin
conjugate: Targeting copper
metabolism in neuroblastoma”.
Chemistry, Physics and
Nanotechnology, University of
Technology Sydney, Sydney 20th
May
2016.
M.E. Warkiani, Faculty of
Engineering, Edith Cowan University,
Perth, Australia 2016
Other Oral
Presentations
M. Parviz, K. Gaus, J.J. Gooding, A dual
optical and electrochemical system for
monitoring cell surface interactions
and the response of cells to
therapeutics, The 67th Annual
Meeting of the International Society of
Electrochemistry, Den Haag,
Netherlands, 21-26 Aug 2016.
B. Gupta, D. Wakefield, N. Di
Girolamo, K. Gaus, P.J. Reece, J.J.
Gooding, In vivo detection of protease
activity using porous silicon
microsensors, World Congress on
Biosensors, Gothenburg, Sweden, 25-
27 May 2016.
V.R. Gonçales, S. Ciampi, J.J. Gooding,
Effect of different electrolytes of the
Hofmeister series on SiOx formation at
alkyne protected silicon surfaces, 19th
Topical Meeting of the International
Society of Electrochemistry, Auckland,
New Zealand, 17-20 April 2016.
P. Sowti, A.H. Soeriyadi, J.J. Gooding,
A Cheap and Simple Approach to
Monitor Sun Exposure based on
Photocatalytic Properties of Titanium
Dioxide, Pittcon 2016, Atlanta, 6-10
March 2016.
M. Kashi, Y.F. Wu, V. Goncales, M.
Choudhury, S. Ciampi, J.J. Gooding,
Electrochemical Behaviour of Highly-
and Poorly-doped p-Si-AuNP
Electrodes, Pittcon 2016, Atlanta, 6-10
March 2016.
A. Barfidokht, S. Ciampi, E. Luais, N.
Darwish, J.J. Gooding, Distance-
Dependent Electron Transfer at
Passivated Electrodes Decorated by
Gold Nanoparticles, International
Conference of Nanoscience and
Nanotechnology 2016, Canberra, 7-11
February 2016.
B. McVey, X. Liu, X. Hao, J.J. Gooding,
R. Seed-mediated synthesis and
characterization of Cu quaternary
chalcogenide nanocrystals,
International Conference of
Nanoscience and Nanotechnology
2016, Canberra, 7-11 February 2016.
R. Tilley, A. McGrath, S. Cheong,
Synthesis of Gold-Palladium
Nanoparticles for Hyperthermia
Cancer Therapy. International
Conference of Nanoscience and
Nanotechnology 2016, Canberra,
7-11 February 2016.
L. Gloag, S. Cheong, J.J Gooding, R.
Tilley, Structural characterisation and
growth study of Au-Ru core-branched
nanoparticles, International
Conference of Nanoscience and
Nanotechnology 2016, Canberra, 7-11
February 2016.
R. Tavallaie, N. Darwish, D.B. Hibbert,
J.J. Gooding, Impact of Single Base pair
Mismatches on Electron-Transfer
Processes at redox labelled-DNA/RNA
Modified Gold Surfaces, International
Conference of Nanoscience and
Nanotechnology 2016, Canberra, 7-11
February 2016.
Y.H. Zheng, X. Lu, A.H. Soeriyadi, X.Y.
Cheng, T. Tabarin, P. Nicovich, L. Rosa,
S.H. Ng, U. Bach, K. Gaus, J.J. Gooding,
Towards Single Molecule Sensors,
International Conference of
Nanoscience and Nanotechnology
2016, Canberra, 7-11 February 2016.
B. Gupta, D. Wakefield, N. Di
Girolamo, K. Gaus, P.J. Reece, J.J.
Gooding, Porous Silicon Microsensors
for the Detection of Protease Activity
In Vivo, International Conference of
Nanoscience and Nanotechnology
2016, Canberra, 7-11 February 2016.
22
R. Piya, B. Gupta, P. J. Reece, J.J.
Gooding, Micropatterned Porous
Silicon Photonic Crystal in Studying
Cellular Heterogeneity, International
Conference of Nanoscience and
Nanotechnology 2016, Canberra, 7-11
February 2016.
S.G. Parker, Y. Yang, S. Ciampi, J.J.
Gooding, Single-Cell Isolation using
Electrochemically-Switchable Surfaces,
International Conference of
Nanoscience and Nanotechnology
2016, Canberra, 7-11 February 2016.
O. Vittorio, M. B. Brandl , G. Cirillo, K.
Kimpton, E. Hinde, M. Kavallaris
Dextran-Catechin conjugate targets
copper metabolism in neuroblastoma.
Advances in Neuroblastoma Research
Association Meetings, Cairns 2016.
O. Vittorio, M. B. Brandl , G. Cirillo, K.
Kimpton, E. Hinde, H. Duong, C. Boyer,
M. Kavallaris. Dextran-Catechin
conjugate: An anticancer nano-
modified natural compound targeting
copper metabolism in neuroblastoma.
AACR Annual Meeting 2016 in New
Orleans, Louisiana.
Sharbeen G, Youkhana J, Mawson A,
McCarroll J, Akerman A, Goldstein D,
and Phillips PA. MutY-homolog
modulates pancreatic cancer cell
survival and chemoresistance. The
Australasian Pancreatic Club Meeting,
2016, Sydney, NSW
Akerman A, Sharbeen G, Holst J,
Youkhana J, Naim S, Liu J, McCarroll J,
Goldstein D, Erkan M and Phillips PA.
Targeting a solute carrier to
reprogram tumour-promoting stromal
cells in pancreatic cancer. The
Australasian Pancreatic Club Meeting,
2016, Sydney, NSW.
Akerman A, Sharbeen G, Holst J,
Youkhana J, Naim S, Liu J, McCarroll J,
Goldstein D, Erkan M, Phillips P.
Targeting a solute carrier to
reprogram tumour-promoting stromal
cells in pancreatic cancer. Australian
Society for Medical Research (ASMR)
NSW State Conference, Sydney, 2016.
M.E. Warkiani, ANZNMF conference, Brisbane, Australia 2016 M.E. Warkiani, EmTech Asia conference, 26-27 January, 2016, Singapore M.E. Warkiani, ISCT 2016 conference, May 25-28, 2016, Singapore Dr Celine Heu, The use of self-
assembled hydrogel for the
development of an in vitro tissue
boundary 3D tumour model
monitored by Light Sheet
Fluorescence Microscopy. 7th
International Nanomedicine
Conference, Sydney, 27-29 June 2016.
Dr Bakul Gupta, Detection of Protease
Activity using Porous Silicon Photonic
Crystals. 7th International
Nanomedicine Conference, Sydney,
27-29 June 2016.
Dr Adam Martin, Controlling self-
assembly in short peptide hydrogels.
7th International Nanomedicine
Conference, Sydney, 27-29 June 2016.
Dr Stephen Parker, Single-Cell
Isolation using Electrochemically-
Switchable Surfaces. 7th International
Nanomedicine Conference, Sydney,
27-29 June 2016.
Ms Maryam Parviz, Developing a
Simultaneous Opto/Electrical
Screening System: A More
Comprehensive methodology to study
cellular responses. 7th International
Nanomedicine Conference, Sydney,
27-29 June 2016.
Dr Roya Tavallaie, Amplified
electrochemical detection of
microRNA by interaction of redox
labelled RNA/RNA duplex with p19
protein. 7th International
Nanomedicine Conference, Sydney,
27-29 June 2016.
Prof Richard Tilley, Solution Synthesis
and Optical Properties of Silicon
Nanocrystals for Biomedical Imaging.
7th International Nanomedicine
Conference, Sydney, 27-29 June 2016.
Mr Vincent Tan, Polymeric hydrogel
used as an extracellular matrix mimic
for 3D cell culturing. 7th International
Nanomedicine Conference, Sydney,
27-29 June 2016.
Mr Jonathan Wojciechowski,
Designing Supramolecular Heat-Set
Hydrogels for 3D Cell Culture. 7th
International Nanomedicine
Conference, Sydney, 27-29 June 2016.
Ms Parisa Sowti Khiabani, A Paper
Based Sensor for Monitor Sun
Exposure. 7th International
Nanomedicine Conference, Sydney,
27-29 June 2016.
Poster Presentations
Sharbeen G, Youkhana J, Mawson A,
McCarroll J, Akerman A, Goldstein D,
Phillips PA. MutY-Homolog modulates
pancreatic cancer cell survival and
chemoresistance. Sydney Cancer
Conference, 2016.
Akerman A, Sharbeen G, Holst J,
Youkhana J, Naim S, Liu J, McCarroll J,
Goldstein D, Erkan M, Phillips PA.
Targeting a solute carrier to
reprogram tumour-promoting stromal
cells in pancreatic cancer. Sydney
Cancer Conference, 2016.
Sharbeen G, Youkhana J, Mawson A,
McCarroll J, Akerman A, Goldstein D,
Phillips PA. MutY-Homolog modulates
pancreatic cancer cell survival and
chemoresistance. European
Pancreatic Club, Liverpool, UK, 2016.
23
ACN members’ poster presentations
at the 7th International
Nanomedicine Conference held
in Sydney from 27-29 June 2016:
Mr Abbas Darestani Farahani, Effect
of Aromatic Capping Group on Packing
of Amino Acids.
Mr Eric Du, Properties of peptide
hydrogels and cardiac stem cells.
Ms Genevieve Duché, Encapsulating
self-assembled peptide hydrogels in
liposomes for drug delivery and
aesthetic therapy.
Mr Md Musfizur Hassan, Rational and
Strategic Design of Hydrogelators for
Controlled Drug Delivery.
Mr Saimon Moraes Silva,
Development of a calibration free
approach for the multiplex microRNA
detection in biological fluids based on
the ‘dispersible electrodes’ concept.
Mr Robert Healey, Tag-specific and
residue-specific fluorescent labelling
of a GPCR protein drug.
Ms Susan Ireland, The Molecular
Pharmacology of the Sweet Taste
Receptor.
Mr Cheng (Johnson) Jiang, Antifouling
featured biosensor: from surface
chemistry to sensing applications.
Ms Mohi Kahram , Electrically
switchable polymers as effective
platforms for smart biosurfaces.
Prof Naresh Kumar, Immobilization of
Quorum Sensing Inhibitors
Dihydropyrrolones as Antibacterial
Coatings.
Mr Andrew Robinson, The Effect of
Amino Acid Constituents on the
Properties of Self-assembled Peptide
Hydrogels for Medical Application.
Mr Alistair Laos, Cooperative subunit
refolding of a light-harvesting protein
through a self-chaperone mechanism.
Mr Ian Lin, Impact of Increasing
Hydrophilicity on Hydrogel
Biocompatibility.
Dr Frieda Mansfeld, An Antibody-
Doxorubicin Conjugate to Target
Neuroblastoma Cells.
Mr Alex Mason, Engineered
polymersomes with asymmetric
membranes for protein encapsulation.
Ms Manchen Zhao, Using nanoscopy
with a single-molecule pull-down
assay based on poly-L-lysine grafted
polyethylene glycol surfaces to
monitor many single protein-protein
interactions.
Mr Walter Muskovic, Identifying
microRNA Therapeutic Targets in
Glioblastoma.
Ms Raheleh Pardehkhorram,
Immuno-Gold Nanorods Composite
for Food Safety Monitoring.
Ms Maryam Parviz, Screening the
effect of a cation-independent
mannose 6-phosphate receptor
inhibitor, PXS 64, on fibrosis using a
label-free and non-invasive method.
Mr Manish Sriram, Single plasmonic
particles for digital biosensing.
Ms Kristel Tjandra, Active Targeting of
Doxorubicin through Conjugation to
Phage Display-Selected Peptide.
Dr Robert Utama, Generation of 3D
Cell Culture Models Using 3D
Bioprinting.
Dr James Webb, Ultra-Fast Energy
Transfer in Fluorescent Perylene
Arrays.
Mr Chin (Ken) Wong, Anisotropically-
Shaped Fluorescent Polymersomes:
From Ellipsoids to Tubes Through Fine-
Tuning of π-Stacking Strengths in
Diblock Terpolymers.
Ms Duyen Nguyen, Highly Modulated
Light-Activated Polymeric Hydrogels
for 3D Cell Culture.
Mr Manish Sriram receiving ACS Sensors
Poster prize from Editor-in-Chief Professor
Justin Gooding.
Poster prize winner Ms Kristel Tjandra presenting her poster at Conference.
Mr Alistair Laos receiving Bioconjugate Chemistry poster prize from Editor-in-Chief Professor Vince Rotello.
24
Collaborating Organisations
The ACN actively pursues research collaboration both within our multi -disciplinary
Centre and outside the Centre. Below is a list of our external research collaboration
partners in 2016.
ANSTO, Australia
ARC Centre of Excellence for
Electromaterials Science, Australia
ARC Centre of Excellence in
Advanced Molecular Imaging,
Australia
Australian Synchrotron, Australia
Boron Molecular, Australia
Children’s Cancer Institute ,
Australia
Clockwerk Pty Ltd, Australia
CSIRO Manufacturing, Australia
Deakin University, Australia
EnGeneic, Australia
Ettason Pty Ltd, Australia
European Molecular Biology
Laboratory (EMBL) Australia Node
in Single Molecule Science, UNSW
Flurosol Industries Pty Ltd,
Australia
Griffith University, Australia
Inventia Australia
Macquarie University, Australia
Mark Wainwright Analytical
Centre, UNSW
Monash Institute of
Pharmaceutical Sciences, Australia
Monash University, Australia
RR Medsciences Pty Ltd, Australia
Sydney Children's Hospital ,
Australia
University of Newcastle, Australia
University of South Australia,
Australia
University of Western Australia,
Australia
University of Wollongong,
Australia
Victor Chang Cardiac Research
Institute, Australia
East China University of Science
and Technology, China
Qingdao University, China
Xi’an Jiaotong University, China
German Cancer Consortium (DKTK)
Dresden and German Cancer
Research Center (DKFZ), Germany
Leibniz Institute of Solid State and
Material Research Dresden
Germany
Center for Radiation Research in
Oncology , Germany
Ruhr Universität Bochum,
Germany
University of Florence, Italy
Victoria University of Wellington,
New Zealand
Madrid University, Spain
University of Geneva, Switzerland
Delft University of Technology
The Netherlands
Radboud University Nijmegen
The Netherlands
Imperial College London, UK
University of Liverpool, UK
Beatson Institute, Glasgow
Scotland, UK
Arizona State University, USA
Center for Nanotechnology in
Society, University of California,
Santa Barbara, USA
Princeton University, USA
University of Texas at Austin, USA
University of California Davis, USA
25
Awards, Prizes and Achievements
There are a number of significant achievements by Centre researchers in 2016. Key
achievements are listed below.
On 23 May 2016, ARC Laureate Fellow and Scientia Professor Justin Gooding was elected Fellow of the Australian Academy of Science for his outstanding contributions to science and scientific research. Justin uses electrochemistry, synthetic chemistry, interfacial physical chemistry, electron transfer theory, protein biochemistry, and cytochemistry, in order to modify surfaces at the molecular level to enable them to specifically recognise biochemical molecules and to transduce that biochemical information to the end user directly within biological fluids. He combines this experience in fundamental bioelectronics with chemometrics to fabricate practical biosensors. His outstanding achievements include the molecular wiring of the enzyme glucose oxidase (a diabetes monitor), molecular wiring of the redox protein cyctochrome-c to silicon, a peptide electrode array to detect bioactive metals, ‘DNA electrodes’, and porous photonic silicon with immobilised peptides able to detect protease activity – aiming for an infection-sensing chip.
Professor Maria Kavallaris was inducted as a Fellow of the Australian Academy of Health and Medical Sciences (AAHMS) on 6 October 2016. The Fellowship acknowledges Professor Kavallaris as an outstanding research leader who has made seminal discoveries on mechanisms of clinical drug resistance and tumour aggressiveness in childhood and adult cancers. Her world leadership in cancer and microtubules, and her discoveries have led to patents and industry linkages for the development of cancer therapeutics. The honour also recognises Professor Kavallaris’s achievements as a founding Director of the Australian Centre for NanoMedicine at UNSW Australia, an innovative cross-disciplinary initiative developing nanotechnology for medical applications. More broadly, her election as a new Fellow pays tribute to her outstanding leadership in medical research advocacy, peer review, mentoring and advanced research policy.
Professor Cyrille Boyer achieved an unprecedented feat by scooping two prestigious awards: the Journal of Polymer Science Innovation Award and the Biomacromolecules/Macromolecules Young Investigator Award at the 252nd American Chemical Society National Meeting & Exposition on August 21-25, 2016, in Philadelphia, Pennsylvania, U.S. The awards were in recognition of his outstanding contributions in development of new functional polymers and new nanomaterials for biological applications. Professor Boyer has made major contributions to the field of polymer science, with a body of work focussed on creating novel, specialised polymers utilising living polymerisation. Employing his expertise in polymer chemistry, Professor Boyer has stimulated a paradigm shift in light-activated polymerisation.
26
Scientia Professor Justin Gooding
- Elected Fellow of the Australian
Academy of Science
- Elected Fellow of the
International Society of
Electrochemistry
- Faraday Medal of the Royal
Society of Chemistry
Electrochemistry Division
- Royal Society of NSW Walter
Burfitt Prize, and the Archibald
Liversidge Medal for 2016
- Appointed Co-Director of NSW
Smart Sensing Network
- Announced winner of the
Biosensors and Bioelectronics Award
for the most original contribution to
Biosensors Congress 2016 for his
keynote speech “Towards Single
Molecule Biosensors using super-
resolution microscopy”
Professor Maria Kavallaris
- Inducted as a Fellow of the
Australian Academy of Health and
Medical Sciences (AAHMS) on 6th
October, 2016
- Awarded a prestigious NHMRC
Principle Research Fellowship valued
at $763,845 for her project entitled:
Precision nanomedicine-based
cancer therapeutics. The award was
announced by Minister for Health on
27th
October, 2016
Dr Alex Soeriyadi
- Selected as one of 13 Australian
scientists to tour China as part of the
Australia-China Young Scientists
Exchange Program (YSEP).
Professor Cyrille Boyer
- 2016 Emerging Investigator by
Chemical Society Reviews
- 2016 Finalist of University of
New South Wales Eureka Prize for
Scientific Research
- 2016 LeFevre Memorial Prize
(awarded by the Australian Academy
of Science)
- 2016 ACS Biomacromolecules/
Macromolecules Award (awarded by
American Chemical Society)
- 2016 Journal of Polymer
Science Innovation (awarded by
Wiley)
- Recognised as one of 20 Rising
Stars at UNSW
Dr Elizabeth Hinde
- Awarded a Cancer Institute
NSW Early Career Fellowship
Dr Majid Ebrahimi Warkiani
- Awarded the Nanyang
Outstanding Young Alumni Award in
Sep 2016
A/Prof Phoebe Phillips
- Invited member of NHMRC
Expert Advisory Grant Committee
Dr David Chang
- Awarded Genito-Urinary
Fellowship Grant by The Royal
Australian & New Zealand College of
Radiologists (RANZCR) $25,000.
David is a PhD student in Maria’s
group.
- Convergent Bio-Nano Science &
Technology Bursary Award – Animal
imaging workshop, Brisbane 26th
August 2016
Dr William Donald
- Awarded the Royal Australian
Chemical Institute (RACI) Peter W.
Alexander Medal for early career
excellence in Analytical Chemistry on
18/10/2016 and RACI Physical
Chemistry Division Lectureship
(2016)
- Project leader of one of the five
NSW Smart Sensing Network flagship
projects.
- Named Emerging Investigator
by the Analyst on 14/10/2016.
- Named Emerging Investigator
by Journal of the American Society of
Mass Spectrometry on 9/11/2016.
Dr Joshua McCarroll
- Cancer Institute NSW Career
Development Fellowship
Mr Walter Muskovic
- Awarded a Brain Foundation
grant at the Art Gallery of NSW on 24
Oct 2016. Walter is a tumor biologist
and a PhD student in Maria’s group.
Awarded 18th
EMBL PhD Symposium
Heidelberg, Germany November
2016 Travel Grant $3,000
Dr Jason Xu
- Awarded a prestigious ARC
Future Fellowship for his 4 year
project entitled: Precisely Controlled
Macromolecular Synthesis through
Green and Sustainable
Chemistry. The award was
announced by Minister for Education
and Training on 1 November, 2016.
Jason is a postdoc in Cyrille’s group.
27
Governance, Our People & Visitors
28
Steering Committee
The Steering Committee provides support, guidance and oversight on strategy and
stakeholder engagement as well as monitoring progress towards the delivery of key
performance indicators and other objectives. The ACN Steering Committee is chaired
by Professor Mark Hoffman (Presiding Dean) and is comprised of members from the
associate Faculties of Science and Medicine. The 2016 Steering Committee meetings
are noted below.
Steering Committee Members May 2 Sep 5 Dec 1
Professor Mark Hoffman (Chairman) Dean of Engineering, UNSW
● ● ●
Professor Rodney Phillips Dean of Medicine, UNSW
●
Professor Peter Lovibond Dean of Science, UNSW
● ● ●
Scientia Professor Ian Dawes School of Biotechnology and Biomolecular Sciences, UNSW
● ● ●
Scientia Professor Justin Gooding ACN Co-Director School of Chemistry, UNSW
● ● ●
Professor Maria Kavallaris ACN Co-Director Children’s Cancer Institute Australia
● ● ●
Professor Cyrille Boyer ACN Co-Director School of Chemical Engineering, UNSW
● ●
Dr Joshua Peterson Interim Centre Manager (Till July 2016) Australian Centre for NanoMedicine
●
Kimberly Edmunds Centre Manager (From August 2016) Australian Centre for NanoMedicine
● ●
29
Organisational Chart
Centre Co-Directors
Professors Justin Gooding, Maria Kavallaris and Cyrille Boyer
Members
Research Associates and PostDocs
Research Students and Honours Students
Associate Members
Centre Manager
Kimberly Edmunds
30
ACN Members and Students
Members
Scientia Prof Katharina Gaus NHMRC Senior Research Fellow Medicine
Prof Naresh Kumar
Science
Professor Richard Tilley
Science
Prof Pall
Thordarson
Science
Conjoint Prof Ivan Greguric ANSTO Life Sciences
A/Prof Phoebe
Phillipps
UNSW Fellowship
Enhancement
Package (NHMRC
CDF) Medicine
A/Prof John
McGhee*
UNSW Art & Design
A/Prof Matthew
Kearnes
ARC Future Fellow
Arts & Social Sci
Dr Joshua
McCarroll
Cancer Institute
CDF Fellow
Medicine
Dr Majid E Warkiani
Engineering
Dr William (Alex) Donald*
Science
Dr Alex Soeriyadi*
NHMRC ECF Fellow
Science
Dr Adam Martin*
NHMRC-ARC Dementia Rsch
Dev Fellow
Science
Dr Edgar Wong*
VC PostDoc
Engineering
Dr Sophia Gu*
NHMRC ECR
Engineering
Dr Damia Mawad*
Science
Dr. Orazio Vittorio*
Cancer Institute
ECF Fellow
Medicine
Dr Jason Xu*
ARC Future Fellow
Engineering
*2016 new members
31
Associate Members
Professor Martina Stenzel
A/Pro Shelli McAlpine
Dr May Lim
Dr Renee Whan
Research Fellows
Dr Elizabeth Hinde (Cancer
Institute ECF)
Dr S R C Vivekchand (VC)
Dr Enrico Klotzsch (VC)
Dr Yuanhui Zheng (VC)
Dr Hongxu Lu (DECRA)
Dr. Padmavathy Bakthavathsalam
(Trust-India Fellow)
Dr. Yuhua Xue (VC)
Post Docs
Dr Celine Heu (till Dec 2016)
Dr Declan Kuch
Dr Frieda Mansfeld
Dr James Webb
Dr Miriam Brandl (till Sep 2016)
Dr Guillaume Longatte
Dr Stephen Parker
Dr Roya Tavallaie
Dr Robert Utama
Dr Lakmali Atapattu (from Mar 2016)
Dr Christopher Fife (till Mar 2016)
Dr James Webb(till Dec 2016)
Dr Wee Teo
Dr Amelia Parker(from Jan 2016)
Dr Sela Po’uha
PhD Students
Mr Nik Nik Mohd Adnan
Ms Laura Jeffress
Ms Anouschka Akerman
Ms Fida’a Alshawawreh*
Ms Sri Augustina
Mr Ali Bagheri
Mr Kumar Bishwajit
Mr Zhenbang Cao
Mr Lachlan Carter
Dr David Chang
Mr Nat Corrigan
Mr Eric Du
Ms Genevieve Duche
Mr Morphy Dumlao
Mr Sanjun Fan*
Mr Abbas Farahani
Ms Helen Forgham
Mr Fei Han
Mr Md Musfizur Hassan
Mr Robert Healey**
Ms Susan Ireland
Mr Cheng (Johnson) Jiang **
Mr Kenward Jung
Ms Mohaddeseh Kahram
Ms Felicity Kao*
Mr Alexander Kross
Ms Joanna Kwiatek
Mr Alistair Laos**
Mr Xun Lu **
Mr Yong (Jerry) Lu (till Nov 2016)
Mr Alex (Yuanqing) Ma
Mr Alex Mason**
Ms Mahdie Mollazade**
Mr Saimon Moraes Silva
Mr Walter Muskovic
Ms Khanh Nguyen
Ms Duyen Nguyen*
Ms Susan Oliver
Ms Amelia Parker**
Ms Rahelleh Pardekhorram
Ms Maryam Parviz **
Ms Ranjana Piya
Mr Bijan Pouryousefi Markhali*
Mr Mehdi Rafeie
Mr Abu Sadat Md. Sayem Rahman
Mr Siva Shanmugam
Mr Saimon Silva*
Ms Parisa Sowti
Mr Manish Sriram
Mr Vincent Tan
Ms Safura Taufik*
Ms Kristel Tjandra
Mr Jason Tran
Mr Jonathan Wojciechowski
Mr Chin (Ken) Wong
Mr Yanfang Wu
Mr Ming Han Eugene Yee
Mr Jonathan Yeow
Ms Leila Zarei
Ms Manchen Zhao
Ms Kelly Zong
Mr. Kumar Sutradhar*
Ms. Zahara Sadrehani*
Ms Rashin Zangeneh*
Thi Diep Nguyen*
Honours Students
Mr Peter O’Mara*
Mr Ian Lin
Mr Michael Lawler
Ms Joy Zhang
Ms Aria Ahmed Cox
Gervase Ng*
Henry Xu*
Peter Judzewitsch*
Centre Administration Kimberly Edmunds
Centre Manager (From Aug 2016)
Dr Joshua Peterson
Research Officer
Mr Eh Hau Pan
Lab Manager
Ms Kathleen Kimpton
Research Assistant
Ms Tara McGilligan
EA to Prof Kavallaris (till Dec 2016)
Mrs Jesu Schlogl
EA to Prof Kavallaris (from Dec 2016)
Ms Rose-Marie Olsson
Senior Research Assistant
Mrs Sona Samuels
Research Assistant
Ms Efremova Varvara
Research Assistant
*joined in 2016
** graduated in 2016
32
Visitors to the ACN
The ACN has hosted a diverse range of visitors from academia and industry within
Australia and around the world during 2016. Our visitors have presented seminars
and met with research staff and students to investigate potential collaboration
opportunities.
A/Professor Ross Dickins Laboratory Head Aust Ctr for Blood Diseases Monash University Australia Dr Belinda Parker ARC Future Fellow Latrobe University Australia Professor David Huang Laboratory Head Cancer and Haematology Walter and Eliza Hall Institute of Medical Research Australia Dr Charles Farnsworth Senior Proteomics Applications Scientist Cell Signalling Technology Australia Dr Paul Timpson Lab Head - Invasion and Metastasis Garvan Institute of Medical Research Australia Dr Samir Taoudi Lab Head – Molecular Medicine Walter and Eliza Hall Institute of Medical Research Australia
Prof Michelle Coote Fellow of Aust Academy of Science Australian National University Prof Gail Risbridger NHMRC Senior Principal Research Fellow Peter MacCallum Cancer Centre Australia Prof James Camakaris The University of Melbourne Prof Phillip Robinson Head, Cell Signalling Unit Children's Medical Research Institute NSW
Professor Brandon Wainwright Director, Inst for Molecular Bioscience The University of Queensland Professor Swaminathan Iyer ARC Future Fellow University of Western Australia Dr Toby Bell Monash University Australia Dr Annette Kunkele Charité Universitätsmedizin Berlin Germany Dr Markus Elsner Senior Editor Nature Biotechnology Germany Dr Peter Gölitz Editor-in-Chief of Angewandte Chemie Wiley-VCH Germany Professor Angelika Eggert Berlin School of Integrative Oncology Germany Prof Addy Pross Ben-Gurion University of the Negev Israel Dr Giuseppe Cirillo The University of Calabria Italy Prof Keji Maruoka Kyoto University Japan Prof Bronwyn Parry King's College London Prof Eric Bakker University of Geenva Switzerland Prof Jan H van Esch Delft University of Technology The Netherlands
Professor Volga Bulmis Izmir Institute of Technology Turkey Prof James Wilsdon Sheffield University UK Dr Jane Calvert University of Edinburgh UK Prof Véronique Gouverneur Oxford University UK Prof Arieh Warshel University of Southern California USA A/Prof Diana M Bowman Arizona State University USA Dr Tito Fojo Columbia University Medical Centre USA Prof Felix Castellano North Carolina State University USA Prof George Whitesides Harvard University USA Dr Jack London Thomas Jefferson University USA Prof Vince Rotello University of Massachusetts Amherst USA Dr Curtis Harris National Cancer Institute USA
33
Publications
Books/Book
Chapters
Chilvers J; Kearnes MB, (eds.),
2016, Remaking Participation:
Science, Environment and
Emergent Publics, Routledge,
Abingdon, Oxon OX14 4RN
Chilvers J;Kearnes M, 2016,
'Science, democracy and
emergent publics', in
Remaking Participation:
Science, Environment and
Emergent Publics, pp. 1 – 27.
Chilvers J;Kearnes M, 2016,
'Remaking participation:
Towards reflexive
engagement', in Remaking
Participation: Science,
Environment and Emergent
Publics, pp. 261 – 288.
Chilvers J;Kearnes M, 2016,
'Participation in the making:
Rethinking public engagement
in co-productionist terms', in
Remaking Participation:
Science, Environment and
Emergent Publics, pp. 31 - 63,
Sharbeen G; McAlpine S;
Phillips P, 2016, 'HSP47: The
new heat shock protein
therapeutic target', in Topics
in Medicinal Chemistry, pp.
197 – 220.
Mawad D; Lauto A; Wallace
GG, 2016, 'Conductive
Polymer Hydrogels', in Kalia S
(ed.), Polymeric Hydrogels As
Smart Biomaterials, edn.
Springer Series on Polymer
and Composite Materials,
Springer Int Publishing Ag, pp.
19 – 44.
Silva SM; Justin Gooding J,
2016, 'Chapter 8: Dispersible
electrodes: An approach to
developing sensing devices
that can quickly detect
ultralow concentrations of
analyte', in RSC Detection
Science, edn. 6, pp. 279 – 295.
Byrne, F. L., McCarroll, J. A.,
and Kavallaris, M. (2016)
Analyses of tumor burden in
vivo and metastasis ex vivo
using luciferase-expressing
cancer cells in an orthotopic
mouse model of
neuroblastoma, In Methods in
Molecular Biology, pp 61-77.
Mansfeld F M, Davis TP,
Kavallaris M (2016),
“Nanotechnology in Medical
Research”. Micro and
nanotechnologies for vaccine
development, pp. 21 – 45.
Journal Articles
Abu-Siniyeh A; Owen DM;
Benzing C; Rinkwitz S; Becker
TS; Majumdar A; Gaus K, 2016,
'The aPKC/Par3/Par6 Polarity
Complex and Membrane
Order Are Functionally
Interdependent in Epithelia
During Vertebrate
Organogenesis', Traffic, vol.
17, pp. 66 – 79.
Adnan NNM; Cheng YY; Ong
NMN; Kamaruddin TT; Rozlan
E; Schmidt TW; Duong HTT;
Boyer C, 2016, 'Effect of gold
nanoparticle shapes for
phototherapy and drug
delivery', Polymer Chemistry,
vol. 7, pp. 2888 – 2903.
Akerman A; Vennin C; Sharbeen
G; Warren SC; Timpson P;
Phillips PA, 2016, 'Novel
therapeutics and preclinical
imaging for pancreatic cancer -
View from the lab', Cancer
Forum, vol. 40, pp. 16 – 22.
Al-Eisawi Z; Stefani C; Jansson
PJ; Arvind A; Sharpe PC; Basha
MT; Iskander GM; Kumar N;
Kovacevic Z; Lane DJR, 2016,
'Novel Mechanism of
Cytotoxicity for the Selective
Selenosemi-carbazone, 2-
Acetylpyridine 4, 4-Dimethyl-3-
selenosemicarbazone
(Ap44mSe): Lysosomal
Membrane Permeabilization',
Journal of Medicinal Chemistry,
vol. 59, pp. 294 – 312.
Andres-Arroyo A; Gupta B;
Wang F; Gooding JJ; Reece PJ,
2016, 'Optical Manipulation and
Spectroscopy of Silicon
Nanoparticles Exhibiting
Dielectric Resonances', Nano
Letters, vol. 16, pp. 1903 – 1910.
Asadnia M; Kottapalli AGP;
Karavitaki KD; Warkiani ME;
Miao J; Corey DP; Triantafyllou
M, 2016, 'From Biological Cilia
to Artificial Flow Sensors:
Biomimetic Soft Polymer
Nanosensors with High Sensing
Performance', Scientific Reports,
vol. 6.
34
Bagheri A; Arandiyan H; Boyer C;
Lim M, 2016, 'Lanthanide-doped
upconversion nanoparticles:
Emerging intelligent light-
activated drug delivery systems',
Advanced Science, vol. 3.
Bagheri A; Yeow J; Arandiyan H;
Xu J; Boyer C; Lim M, 2016,
'Macromol. Rapid Commun.
11/2016.', Macromol Rapid
Commun, vol. 37, pp. 940.
Bagheri A; Yeow J; Arandiyan H;
Xu J; Boyer C; Lim M, 2016,
'Polymerization of a
Photocleavable Monomer Using
Visible Light', Macromolecular
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Biocompatibility with
Glucosamine-Functionalized
Star Polymers',
Biomacromolecules,
vol. 17, pp. 1170 – 1178.
Wu Y; Kashi MB; Yang Y;
Gonçales VR; Ciampi S; Tilley
RD; Gooding JJ, 2016, 'Light-
activated electrochemistry on
alkyne-terminated Si(100)
surfaces towards solution-
based redox probes',
Electrochimica Acta, vol. 213,
pp. 540 – 546.
Xu J; Shanmugam S; Fu C;
Aguey-Zinsou KF; Boyer C,
2016, 'Selective
Photoactivation: From a Single
Unit Monomer Insertion
Reaction to Controlled
Polymer Architectures',
Journal of the American
Chemical Society, vol. 138, pp.
3094 – 3106.
Yang Y; Ciampi S; Choudhury
MH; Gooding JJ, 2016, 'Light
Activated Electrochemistry:
Light Intensity and pH
Dependence on
Electrochemical Performance
of Anthraquinone Derivatized
Silicon', Journal of Physical
Chemistry C, vol. 120, pp. 2874
– 2882.
Yang Y; Ciampi S; Zhu Y;
Gooding JJ, 2016, 'Light-
Activated Electrochemistry for
the Two-Dimensional
Interrogation of Electroactive
Regions on a Monolithic
Surface with Dramatically
Improved Spatial Resolution',
Journal of Physical Chemistry
C, vol. 120, pp. 13032 – 13038.
Yeow J; Shanmugam S;
Corrigan N; Kuchel RP; Xu J;
Boyer C, 2016, 'A
polymerization-induced self-
assembly approach to
nanoparticles loaded with
singlet oxygen generators',
Macromolecules, vol. 49, pp.
7277 – 7285.
Yeow J; Sugita OR; Boyer C,
2016, 'Visible Light-Mediated
Polymerization-Induced Self-
Assembly in the Absence of
External Catalyst or Initiator',
ACS Macro Letters, vol. 5, pp.
558 – 564.
Yeow J; Xu J; Boyer C, 2016,
'Facile synthesis of worm-like
micelles by visible light
mediated dispersion
polymerization using
photoredox catalyst', Journal
of Visualized Experiments, vol.
2016.
Zhang J; Yan S; Yuan D; Alici G;
Nguyen NT; Ebrahimi Warkiani
M; Li W, 2016, 'Fundamentals
and applications of inertial
microfluidics: A review', Lab
on a Chip - Miniaturisation for
Chemistry and Biology, vol. 16,
pp. 10 – 34.
Zhang L; Vogel YB; Noble BB;
Gonçales VR; Darwish N; Brun
AL; Gooding JJ; Wallace GG;
Coote ML; Ciampi S, 2016,
'TEMPO Monolayers on
Si(100) Electrodes:
Electrostatic Effects by the
Electrolyte and Semiconductor
Space-Charge on the
Electroactivity of a Persistent
Radical', Journal of the
American Chemical Society,
vol. 138, pp. 9611 – 9619.
Zheng Y; Jiang C; Ng SH; Lu Y;
Han F; Bach U; Gooding JJ,
2016, 'Unclonable Plasmonic
Security Labels Achieved by
Shadow-Mask-Lithography-
Assisted Self-Assembly',
Advanced Materials, vol. 28,
pp. 2330 – 2336.
41
Cover Gallery
(From Left to Right, Top to Bottom)
Drug Delivery: Lanthanide-Doped Upconversion Nanoparticles: Emerging Intelligent Light-Activated Drug Delivery Systems (Adv. Sci. 7/2016), Ali Bagheri, Hamidreza Arandiyan, Cyrille Boyer and May Lim
(Front Cover) Controlled Polymerization: Beyond Traditional RAFT: Alternative Activation of Thiocarbonylthio Compounds for Controlled Polymerization (Adv. Sci. 9/2016), T. G. McKenzie, Q. Fu, M. Uchiyama, K. Satoh, J. Xu, C. Boyer, Masami
Kamigaito, Greg Qiao (Frontispiece Inside Cover) A Polymerization-Induced Self-Assembly Approach To Nanoparticles Loaded With Singlet Oxygen Generators (Macromolecules,
9/2016), J. Yeow, S. Shanmugam, N. Corrigan, R. Kuchel, J. Xu, C.
Boyer (Front Cover)
Targeted Drug Delivery: Carbon-Quantum-Dots-Loaded Mesoporous Silica Nanocarriers with pH-Switchable Zwitterionic Surface and Enzyme-Responsive Pore-Cap for Targeted Imaging and Drug Delivery to Tumor (Adv. Health. Mater. 12/2016), X. Chen, Z.N. Liu, J.J.
Gooding, Y.S. Zhou (Inside Front Cover) Star Polymers (Chemical Reviews, 12/2016), J. M. Ren, T. G. McKenzie, Q. Fu, E. H. H. Wong, J. Xu, Z. An, S. Shanmugam, T. P. Davis, C. Boyer,
and G. G. Qiao (Front Cover Centre Image)
Polymerization of a Photocleavable Monomer Using Visible Light (Macromol. Rapid Commun. 11/2016), Ali Bagheri, Jonathan Yeow, Hamidreza Arandiyan, Jiangtao Xu, Cyrille Boyer and May Lim
(Back Cover) The Interaction of CORM-2 with Block Copolymers Containing Poly(4-vinylpyridine): Macromolecular Scaffolds for Carbon Monoxide Delivery in Biological Systems (Macromol. Rapid Commun. 9/2016), Diep Nguyen, Nik Nik M. Adnan,
Susan Oliver and Cyrille Boyer (Front Cover) A Logic Gate for External Regulation of Photopolymerization(Polymer Chemistry, 42/2016), S. Shanmugam, J. Xu and C.
Boyer (Inside Front Cover)
42
Financial Report
43
Above: The mitochondria (orange) and endosomes (blue) inside a virtual breast cancer cell. Image: John McGhee
Australian Centre for NanoMedicine
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