olga klepitskaya, m.d. - university of colorado … vitae olga klepitskaya, m.d. academic address:...

12
CURRICULUM VITAE OLGA KLEPITSKAYA, M.D. Academic Address: Clinic Address University of Colorado Denver University of Colorado Hospital Academic Office 1, Mr. 5219 1635 Aurora Ct. 12631 East 17 th Avenue, Box B185 4 th Floor, Neurology Aurora, CO 80045 Aurora, CO 80045 Phone: (303) 724-2210 Phone: (720) 848-2080 Fax: (303) 724-2212 Fax: (720) 848-2106 Research Affiliation: Veteran Administration Hospital Clinical Translational 1055 Clermont Street Research Center Denver, CO 80220 12401 E 17 th Ave, B141, Phone: (303) 393-2874 Aurora, CO 80045 Fax: (303) 393-4648 1. Education: 1973-1983 School #5, Khabarovsk, Russia, graduated with Gold Medal, GPA 5.00 of 5.00 1983-1989 Far Eastern State Medical University (Khabarovsk State Medical Institute), Khabarovsk, Russia, GPA 5.00 of 5.00, graduated with Honors, 1989-1996 Neurology Residency, Far Eastern State Medical University, Khabarovsk, Russia 1996 Neurophysiology Fellowship, Far Eastern State Medical University, Khabarovsk 2001-2002 Internal Medicine Internship, Resurrection Medical Center, Westlake Hospital Melrose Park, Illinois 2002-2005 Neurology Residency, University of Colorado Denver (UCD), Aurora, Colorado 2005-2006 Movement Disorders Fellowship, Stanford University Medical Center, Stanford, California 2. Academic Appointments: 1990-1992 Instructor in Neurology, Department of Speech Disorders and Therapy, Far Eastern State Pedagogical University, Khabarovsk, Russia 1990-1992 Instructor in Neurology, Department of Neurology, Far Eastern State Medical University, Khabarovsk, Russia 1994-1998 Instructor in Neurophysiology, Department of Continued Medical Education, Far Eastern State Medical University, Khabarovsk, Russia 2006-2008 Clinical Instructor, Department of Neurology, University of Colorado Denver, Aurora, CO 2008-Present Assistant Professor, Department of Neurology, University of Colorado Denver, Aurora, CO 3. Hospital, government or other professional positions: 1989-1990 Research Associate, Central Research Laboratory, Far Eastern State Medical University, Khabarovsk, Russia 1989-1996 Teaching Assistant, Department of Neurology, Far Eastern State Medical University, Khabarovsk, Russia 1992-1994 Director of Public Relations Department, Far Eastern Association of Medical Workers, Khabarovsk, Russia

Upload: lydung

Post on 27-Apr-2018

223 views

Category:

Documents


4 download

TRANSCRIPT

CURRICULUM VITAE

OLGA KLEPITSKAYA, M.D.

Academic Address: Clinic Address

University of Colorado Denver University of Colorado Hospital

Academic Office 1, Mr. 5219 1635 Aurora Ct.

12631 East 17th Avenue, Box B185 4

th Floor, Neurology

Aurora, CO 80045 Aurora, CO 80045

Phone: (303) 724-2210 Phone: (720) 848-2080

Fax: (303) 724-2212 Fax: (720) 848-2106

Research Affiliation: Veteran Administration Hospital

Clinical Translational 1055 Clermont Street

Research Center Denver, CO 80220

12401 E 17th Ave, B141, Phone: (303) 393-2874

Aurora, CO 80045 Fax: (303) 393-4648

1. Education:

1973-1983 School #5, Khabarovsk, Russia, graduated with Gold Medal, GPA 5.00 of 5.00

1983-1989 Far Eastern State Medical University (Khabarovsk State Medical

Institute), Khabarovsk, Russia, GPA 5.00 of 5.00, graduated with Honors,

1989-1996 Neurology Residency, Far Eastern State Medical University, Khabarovsk, Russia

1996 Neurophysiology Fellowship, Far Eastern State Medical University, Khabarovsk

2001-2002 Internal Medicine Internship, Resurrection Medical Center, Westlake Hospital

Melrose Park, Illinois

2002-2005 Neurology Residency, University of Colorado Denver (UCD), Aurora, Colorado

2005-2006 Movement Disorders Fellowship, Stanford University Medical Center, Stanford,

California

2. Academic Appointments:

1990-1992 Instructor in Neurology, Department of Speech Disorders and Therapy, Far

Eastern State Pedagogical University, Khabarovsk, Russia

1990-1992 Instructor in Neurology, Department of Neurology, Far Eastern State Medical

University, Khabarovsk, Russia

1994-1998 Instructor in Neurophysiology, Department of Continued Medical Education,

Far Eastern State Medical University, Khabarovsk, Russia

2006-2008 Clinical Instructor, Department of Neurology, University of Colorado Denver,

Aurora, CO

2008-Present Assistant Professor, Department of Neurology, University of Colorado Denver,

Aurora, CO

3. Hospital, government or other professional positions:

1989-1990 Research Associate, Central Research Laboratory, Far Eastern State Medical

University, Khabarovsk, Russia

1989-1996 Teaching Assistant, Department of Neurology, Far Eastern State Medical

University, Khabarovsk, Russia

1992-1994 Director of Public Relations Department, Far Eastern Association of Medical

Workers, Khabarovsk, Russia

1992-1994 Medical Journalist and Editor, Far Eastern TV/Radio Station, Khabarovsk,

Russia

1994-1998 Attending Neurologist, Department of Neurology, Regional Hospital #1,

Khabarovsk, Russia

1996-1998 Director, Electroencephalography Laboratory, Department of Neurodiagnositcs,

Regional Hospital #1, Khabarovsk, Russia

1996-1998 Neurophysiologist, Department of Neurodiagnostics, Regional Hospital #1,

Khabarovsk, Russia

1998-1999 Research Assistant, Department of Neuroscience, Sleep Laboratory,

Washington State University, Pullman, Washington

1999-2001 Medical and Social Interpreter, Social and Health Services, State of Washington,

Spokane, Washington

2000 Medical Consultant, Ukrainian-American Educational Project, Washington

State University, Pullman, Washington

2000-2001 Electroencephalography Technician, Gritman Medical Center, Moscow, Idaho

2006 – present Attending Neurologist, University of Colorado Hospital, Aurora, Colorado

2007-2008 Attending Neurologist, The Children’s Hospital, Aurora, Colorado

2007-present Staff Neurologist, Veterans Administration Hospital, Denver, Colorado

4. Honors, Special Recognitions, and Awards:

1983 Gold Medal for Excellence, High School # 5, Khabarovsk, Russia

1983 First Place Award of All-Russian Academic Olympiad in Chemistry

1985-1989 Federal Highest Individual Scholarship, named by V.I. Lenin, Far Eastern State

Medical University, Khabarovsk, Russia

1989 Graduated with Honors, Far Eastern State Medical University, Khabarovsk,

Russia

2011 Research Abstract Selected by Faculty 1000 as a “Particularly Important

Development in the Field” at the 10th International Congress on Alzheimer’s and

Parkinson Diseases at http://f1000.com/about/whatis

2011 Scholarship from the American Neurological Association for the Translational

and Clinical Research Course for Clinician, Scientists, Baltimore, Maryland

(declined attendance)

2011 “Doctor of the Month,” University Physician’s Incorporated CU Doctors

Website http://www.cudoctors.com/find-a-doctor/?keywords=olga%20klepitskaya

2011 Scholarship from the National Institute of Health for the National Institute of

Neurological Disorders and Stroke (NINDS) Clinical Trial Methods Course

(CTMC), Vail, Colorado (declined attendance).

2012 Leadership Development Scholarship from the American Academy of Neurology

for the Course in Leading Others, New Orleans, Louisiana

2012 Scholarship from the National Institute of Health for the National Institute of

Neurological Disorders and Stroke (NINDS) Clinical Trial Methods Course

(CTMC), Vail, Colorado

2012 Best Doctors in America 2013 database, selected by peers

2012 Best Doctors for executives, selected by Colorado Biz magazine

2013 Listed in Guide to America’s Top Physicians by SLD Industries, Inc.

5. Professional Organizations and Affiliations:

1999-indefinite Russian Association of Neurologists and Neurosurgeons

2003-present American Academy of Neurology (AAN)

2006-present Movement Disorders Society (MDS)

2006-2007 International Society of History of Neurology

2006-present Parkinson Association of the Rockies (PAR)

2007-present Parkinson Study Group (PSG) – membership by credentialing

2006-present Colorado Society of Clinical Neurology

2013-present American Neurological Association (ANA)

6. Major Committee and Service Responsibilities:

University of Colorado School of Medicine: o 2008-present Co-Director, University of Colorado Hospital Deep Brain Stimulation

Program o 2012 “Hearts of All Ages” fundraising event organization committee

Denver Veteran Administration Hospital:

o 2007-present Director, Eastern Colorado satellite of Parkinson Disease Research,

Education and Clinical Center (PADRECC)

7. Licensure and Board Certification:

1996-indefinite Medical Doctor-Neurologist, Government of Russian Federation,

Ministry of Healthcare, Far Eastern Office

1998-2008 Medical Doctor-Neurologist of the First Qualification Level,

Government of Russian Federation, Ministry of Healthcare, Far Eastern

Office

1999-indefinite Medical and Social Interpreter (English- Russian), Department of Social

and Health Care Services, State of Washington

2001-2002 State of Illinois – Physician Training License

2002-2005 State of Colorado – Physician Training License

2005-2007 State of California – Physician and Surgeon License

2006-present State of Colorado – Medical License

2008-2018 Diplomat of American Board of Psychiatry and Neurology

8. Review and Referee Work:

Ad Hoc:Reviewer: o American Journal of Speech Language Pathology o Cephalgia

Editorial Board Member:

o Brain Disorders and Therapy

9. Invited Lectures and Presentations:

Local: o Klepitskaya O. Tick-Born Encephalitis: What can we Learn from it About the West Nile

Virus Infection? Neurology Grand Rounds, UCD, March 2005.

o Klepitskaya O. Deep Brain Stimulation: Past, Present, and Future. Neurology Grand

Rounds, UCD, April 2007.

o Klepitskaya O. Parkinsonism, Misinterpreted as Status Epilepticus. Neurology Grand

Rounds, UCD, October 2007.

o Klepitskaya O. Neurosurgery for Parkinson Disease beyond DBS. Neurology Grand

Rounds, UCD, August 2009.

o Klepitskaya O. Neurosurgery for Parkinson Disease. Neurosurgery Grand Rounds,

UCD, March 2009.

o Grier L, Hoyt B, Klepitskaya O. Psychiatric Considerations in Deep Brain Stimulation

Surgery for Parkinson Disease. Psychiatry Grand Rounds, UCD, April 2009.

o Klepitskaya O. Dopamine Dysregulation Syndrome. Neurology Grand Rounds, UCD,

March 2011.

o Klepitskaya O. Update on Neurosurgery for Parkinson Disease. Neurosciences Seminar,

Denver, CO, April 2011.

o Klepitskaya O. Deep Brain Stimulation for Early Parkinson Disease. Neurology Grand

Rounds, UCD, July 2012.

o Leehey M, Hedeman J, Klepitskaya O, et al. Medication Adherence in Parkinson

Disease. Quality Improvement Report. Neurology Grand Rounds, University of Colorado

Denver, May 2013.

Regional: o Klepitskaya O. Deep Brain Stimulation: Past, Present, and Future. Colorado Society of

Clinical Neurology, Denver, CO, April 2007.

o Klepitskaya O. Deep Brain Stimulation: Past, Present, and Future. 20th Annual

Conference, ‘Neurosurgery of the Rockies,’ Vail, CO, February 2007.

o Klepitskaya O. Neurosurgery for Parkinson Disease Beyond DBS. 22nd

Annual

Conference, ‘Neurosurgery of the Rockies,’ Beaver Creek, CO, February 2009.

o Klepitskaya O. Update on Neurosurgery for Parkinson Disease. Colorado Society of

Clinical Neurology, Denver, CO, November 2010.

o Klepitskaya O. Deep Brain Stimulation for Early Parkinson Disease. 25th Annual

Conference, ‘Neurosurgery of the Rockies,’ Beaver Creek, CO, February 2012.

o Klepitskaya O. Programming of Deep Brain Stimulation for Parkinson disease.

Practical clues and Case Presentations. Regional DBS Programming Workshop.

December 2012, Denver, CO. 19 attendees

National: o Klepitskaya O. Tick-Born Encephalitis: What can we learn from it about the West Nile

Virus Infection? Department of Neurology, Stanford University, December 2005.

o Klepitskaya O. Parkinsonism, Misinterpreted as Status Epilepticus. Department of

Neurology, Stanford University, May 2006.

o Klepitskaya O. Primary Dystonia Misdiagnosed as Parkinson Disease. National VA

Parkinson Disease Consortium Meeting, San Francisco, CA, September 2010.

o Klepitskaya O. Deep Brain Stimulation: Patient Selection Workshop. National DBS

Forum, San Francisco, CA, October 2011.

o Klepitskaya O. Deep Brain Stimulation for Early Parkinson Disease, invited lecture,

Banner Sun Health Research Institute, Phoenix, AZ, April 2012.

International: o Klepitskaya O. Response of the Subthalamic Nucleus Neurons to Vocalization. 1

st

international symposium, “Basal Ganglia Speech Disorders and Deep Brain Stimulation.”

London, England, July 2007.

10. Teaching Record

Presentations to Medical Students:

2009 Phenomenology of Movement Disorders, 2nd

year medical students core curriculum.

2010 Phenomenology of Movement Disorders, 2nd

year medical students core curriculum.

2011 Phenomenology of Movement Disorders, 2nd

year medical students core curriculum.

Presentations to Residents:

September, 2007 Deep Brain Stimulation, Physical Medicine and Rehabilitation Residents

August, 2008 Deep Brain Stimulation, Neurology Residents

May, 2009 Psychogenic Movement Disorders and Tardive Syndromes, Neurology

Residents

October, 2009 Dystonia, Neurology Residents

Psychogenic Movement Disorders, Neurology Residents

January, 2010 Overview of Movement Disorders, Family Medicine Residency program

February, 2010 Deep Brain Stimulation, Neurology Residents

January, 2011 Overview of Movement Disorders, Family Medicine Residency program

January, 2012 Psychogenic Movement Disorders, Neurology Residents

Surgical treatment of Movement Disorders, Neurology Residents

January, 2012 Overview of Movement Disorders, Family Medicine Residency program

September, 2012 Surgical treatment of Movement Disorders, Neurology Residents

September, 2013 Surgical treatment of Movement Disorders, Neurology Residents

Teaching CME courses:

September, 2009 Pharmacological Treatment of Parkinson disease. UCD CME

course, “Advances in Parkinson Disease and Multiple sclerosis,”

Denver CO

July, 2010 Advances in treatment of Movement disorders. St. Mary Hospital,

Grand Junction, CO

April, 2009 Deep Brain Stimulation. Continued Nursing Education course,

Aurora Colorado

September, 2012 Surgical Treatment of Parkinson disease. UCD CME course,

“Advances in Parkinson Disease and Multiple sclerosis,”

Denver CO

September, 2013 Treatment of Tremor. UCD CME course, “Movement Disorders

and Epilepsy,” Denver CO

Ward/Clinic Attending Duties:

2006-present Supervision and bedside teaching of medical students, pharmacy

students, Neurology and Internal Medicine residents, and Movement

disorders Fellow . UCH Movement Disorders Clinic. 16 hours/week

average.

2006-present Teaching and training of Movement Disorders fellows, physician

assistants, and nurse practitioners in subcortical mapping with

microelectrode recording for Deep Brain Stimulation (DBS)

implantation, UCH Operative Room, 8 hours/week average.

2006-present Teaching and training of movement disorders fellows, nurse

practitioners, and physician assistants in DBS programming, UCH

Movement Disorders Clinic. 16 hours/week average.

2006-present Teaching and training of movement disorders fellows, and neurology

residents in botulinum toxin.

2008- 2010 Attending on inpatient Neurology ward, and bedside teaching medical

students and neurology residents, UCH – 4-6 weeks per year.

Research mentorship:

Movement Disorders Fellows:

o Heather Ene, 2007-2009

Project title: “The effect of yoga on quality of life in Parkinson disease patients, and Gait

and balance outcome after DBS for Parkinson disease.”

o Aaron Haug, 2011-2012

Project title: “Number of microelectrode recording passes during bilateral staged vs.

unstaged deep-brain stimulation surgery for Parkinson's disease.”

Neurology Residents:

o Christy Young, 2009- 2010

Project title: Residency graduation project: Possibility of disease modifying effect of

Deep Brian Stimulation.

o Andreas Muchas- Martin, 2012 – Current.

Project Title: Possibility of disease modifying effect of Deep Brian Stimulation.

o Drew Kern, 2011 – 2012.

Project title: An Objective Double-Blind Evaluation of Bupropion and Citalopram in an

Individual with Friedreich Ataxia. Medical Students:

o Kathleen Reid, 2008-2009.

Project title: Prevalence of dopamine dysregulation syndrome in Parkinson’s disease

patients-candidates for Deep Brain Stimulation.

o John Fowler, 2008-2010.

Project title: Number of microelectrode recording passes during bilateral staged vs.

unstaged deep-brain stimulation surgery for Parkinson's disease.

o Tyson Oberdorfer, 2011- 2012.

Project title: “Microvascular white matter disease as a predictive factors for cognitive

outcome after bilateral Subthalamic Nucleus Deep Brain Stimulation for Parkinson

Disease.”

o Tam Nguen, 2011-2012.

Project title: Primary Dystonia Misdiagnosed as Parkinson Disease.

o Alexander Neuwelt, 2012 .

Project title: Primary Dystonia Misdiagnosed as Parkinson Disease.

o Thomas Ragole, 2012-Current.

Project title: Disease modifying effect of Deep Brain Stimulation.

Patient Outreach and Education:

Treatment of Essential Tremor: International Essential Tremor Foundation, patient education

seminar, September 2007, Colorado Springs, CO, 70 attendees

Deep Brain Stimulation for Parkinson’s disease: Parkinson Association of the Rockies (PAR),

October 2007, Denver, CO, 70 attendees

PD 101: Parkinson Association of the Rockies (PAR), October 2008, Denver, CO, 30 attendees

Treatment of Essential Tremor: International Essential Tremor Foundation patient education

seminar, October 2009, Denver CO, 200 attendees

DBS for Parkinson disease: Davis Phinney Foundation, Victory Summit, October 2009,

Westminster CO, 200 attendees

Neurologists speak about Yoga therapy: Publication in “Yoga Therapy Today,” Journal by, The

International Association of Yoga Therapists, March 2009; 5(1):8

Deep Brain Stimulation: Parkinson Support Group, June 2010, Pueblo, CO, 30 attendees

Deep Brain Stimulation for Dystonia: Dystonia Support Group, June, 2010, 25 attendeed.

Deep Brain Stimulation for Movement Disorders: Patient Symposium, July 2010, Grand

Junction, CO, 300 attendees

Deep Brain Stimulation: University of Colorado patient education Symposium, November 2010

Deep Brain Stimulation. Patient education Symposium, July 2011, Basalt, CO

Deep Brain Stimulation: Parkinson’s Association of the Rockies, “Doctor is In”: November, 2011,

Colorado Springs, CO, 100 attendees; and February 2012, Loveland, CO, 45 attendees

Deep Brain Stimulation for Movement Disorders: Parkinson Support Group, July 2012, Edwards,

CO, 15 attendees

DBS for Parkinson disease: Davis Phinney Foundation, Victory Summit, November 2012,

Denver CO, 400 attendees

Physicians Outreach and Education:

Visiting lectures to local physicians’ offices with discussions regarding patients’ selection,

outcomes and referral process to Deep Brain Stimulation surgery:

Kaiser Permanente Neurology Group, Denver, CO

Drs. London, Nitka, Renkin, Ament, Smith. Lakewood, CO

Drs. Zacaryas and Miller, Boulder, CO

Drs. Redosh, Seibert, Wheatridge, CO

Drs. Poiscne, Fedor, Thornton, CO

Drs. Sunku, Rawat, Smith, Cohen, Pueblo, CO

Drs. Shaffer, Kerber, Cheyenne, WY

Drs. Lopresti, Himes, Ball; Scottsbluff, NE

Drs. Schmitt, Jacobs, Loveland, CO

Dr. Siegel; Greeley, CO

Drs. Round, Ginsburg, Stambuck, McNutt, Denver. CO

Drs. Dean, Burnbaum, Gilman; Grand Junction, CO

DR. Gipson, Edwards, CO

Public Relations and Marketing:

Deep Brain Stimulation eases Parkinson’s: Denver Post, and Colorado Channel 4 News, May

2008, Denver, CO

Her Colors flying: Denver Post, January 2009, Denver, CO

Deep Brain Stimulation for Movement Disorders: report from the Patient Symposium, July 2010,

Grand Junction, CO, featured on Grand Junction Channel 11 News

“7 Everyday Hero” Award Presentation to DBS patient and family liaisons and DBS patients’

support group coordinators Valerie Graham and Kate Kelsall, featured on Colorado Channel 7

News.

Yoga Used to Treat Parkinson’s Disease: Channel 7 News, August 2010, Denver, CO

Overview of Movements Disorders. Presentation to UCH Foundation guests and community

leaders, February and March 2012

Research and Scholarly activities:

Sponsored research and clinical trials:

NIH NIDCD 9/07-9/12

Lorraine Ramig, PhD, CCC-SLP (PI) Total Award: N/A

“Intensive Voice Treatment (LSVT®LOUD) for Parkinson’s Disease Following Deep Brain Stimulation

of the Subthalamic Nucleus”

Role: Consultant

Solstice Neurosciences, Inc. 9/07-9/10

Eric Papert, MD (PI) Total Award: $91,981

“A Multi-Center, Randomized, Double-Blind, Placebo-Controlled, Single Treatment, Sequential Dose-

Escalation, Safety, Tolerability and Preliminary Efficacy Study of MYOBLOC ® for the Treatment of

Troublesome Sialorrhea in Parkinson’s Disease Patients”

Role: Primary Investigator

UCB Biosciences, Inc. 3/08-2/12

Whitesides, J. (PI) Total Award: $266,994

“Multi-Center, Randomized, Double-Blind, Placebo-Controlled, 5-Arm, Parallel-Group Trial to assess

Rotigotine Transdermal System Dose Response in Subjects with Advanced-Stage Parkinson Disease”

Role: Co-Investigator

Neurologix, Inc. 6/08-6/14

During, M. (PI) Total Award: $1,237,580

“Phase 2 Safety and Efficacy Study Evaluating Glutamic Acid Decarboxylase Gene Transfer to the

Subthalamic Nuclei in Subjects with Advanced Parkinson Disease”

Role: Neurophysiologist

Alzheimer’s Association 9/09 - Current

Victoria Pelak, MD (PI) Total Award: N/A

“Visuospatial Assessment of Virtual 3D Radial Optic Flow Illusion in Healthy Aging, Mild Alzheimer’s

Disease and Pre- and Post- Deep-Brain Stimulation (DBS) Parkinson’s Disease Subjects”

Role: Co-Investigator

Pico-Tesla Magnetic Therapies 4/09-11/11

Olga Klepitskaya, MD (PI) Total Award: $248,105

“Randomized, Double-Blind, Sham-Stimulation Controlled Study of the Application of Magnetic Fields

Using the Resonator Device for the Treatment of Parkinson Disease”

Role: Primary Investigator

IMPAX Pharmaceuticals 3/10-12/11

Olga Klepitskaya, MD (PI for UCD) Total Award: $254,255

“Study to Evaluate the Safety and Efficacy of IPX066 in Advanced Parkinson Disease”

Role: Primary Investigator

Tercica, Inc. (A Subsidiary of the IPSEN Group) 8/11-7/14 Current

Wes Cetnarowski, MD (PI for UCD) Total Award: $78,795

“DYSPORT ™ for Injection Abobotulinumtoxin A Neurotoxin Clinical and Health Economics Outcomes

Registry in Cervical Dystonia (ANCHOR – CD)”

Role: Primary Investigator

Biotie 12/11-12/14

Dr. Stephen Bandak, MB BS MRCP (PI) Total Award: $241,285

“A Double-Blind, Randomized, Placebo-Controlled Study of the Safety and Efficacy of SYN115 as

Adjunctive Therapy in Levodopa-Treated Parkinson’s Subjects with End of Dose Wearing off”

Role: Primary Investigator

Sponsor : NIH-NINDS 1/13 - Current

Cirys Zabetian, PhD (PI) Total Award: $260,000

“PAGER: Parkinson”s Genetic Research Study”

Role: Primary Investigator

Solstice Neurosciences, LLC a subsidiary of US World Meds, LLC.

Olga Klepitskaya, MD (PI for UCD)

“A Phase 3, Multicenter, Double-Blind, Placebo-Controlled, Single-Treatment Efficacy and Safety Study

of MYOBLOC® (Part A) Followed by Open-Label, Multiple-Treatment with MYOBLOC® (Part B) in

the Treatment of Troublesome Sialorrhea in Adult Subjects”

Role: Primary Investigator

Ipsen Biopharmaceuticals, Inc.

Olga Klepitskaya, MD (PI for UCD)

“A Phase IIIb, Multicentre, Randomised, Double-Blind, Placebo-Controlled Study Evaluating the

Efficacy and Safety of DYSPORT Using 2 mL Dilution in Adults with Cervical Dystonia”

Role: Primary Investigator

Ipsen Biopharmaceuticals, Inc.

Olga Klepitskaya, MD (PI for UCD)

“A Phase IIIb, Prespective, Multicentre, Open-Label Extension Study to Assess Long Term Safety and

Effectiveness of DYSPORT Using 2mL Dilution in Adults with Cervical Dystonia”

Role: Primary Investigator

Research Grants:

Boedecker Foundation Parkinson Research Grant. 2009-2011

Donated to the UCD Movement Disorders group for Parkinson Disease related research in honor

of Julie Berardi, Deep Brain Stimulation patient.

Total award $200,000

Investigator Initiated Research:

Sponsor N/A 1/06 – 12/07

Ojemann, MD (PI) Total Award – N/A

Response of the Subthalamic Nulcleus Neurons to Vocalization

Role Co- Investigator

Sponsor N/A 1/08- 5/09

Olga Klepitskaya, MD (PI) Total Award: N/A

“Three-Dimensional Computerized Model of Human Basal Ganglia for Microelectrode Recording During

Deep Brain Stimulation Surgery”

Role: Primary Investigator

Sponsor N/A 1/08- 5/09

Ojemann, MD (PI) Total Award: N/A

Development of Mock microelectrode recording software for sham surgery controlled clinical trials of

surgical treatments for Parkinson’s disease

Role: Co-Investigator

Boedecker Foundation Parkinson Research Grant 12/09-12/11

Benzi Kluger, MD, MS (PI) Total Award: $200.000

“Magnetoencephalography (MEG) and Deep Brain Stimulation (DBS) in Parkinson’s Disease (PD)”

Role: Co-Investigator

Boedecker Foundation Parkinson Research Grant 12/09-12/11

Olga Klepitskaya, MD (PI) Total award: $200.000

“Gait and balance outcomes after bilateral Subthalmic Nucleus Deep Brain Stimulation surgery for

Parkinson disease”

Role: Primary Investigator

Boedecker Foundation Parkinson Research Grant 12/09-12/11

Olga Klepitskaya, MD (PI) Total award: $200.000

Number of microelectrode recording passes during bilateral staged vs. unstaged deep-brain stimulation

surgery for Parkinson's disease.

Role: Primary Investigator

Boedecker Foundation Parkinson Research Grant 12/09-12/11

Olga Klepitskaya, MD (PI) Total award: $200.000

Prevalence of dopamine dysregulation syndrome in Parkinson’s disease patients-candidates for deep

brain stimulation

Role: Primary Investigator

Boedecker Foundation Parkinson Research Grant 12/09-12/11

Olga Klepitskaya, MD (PI) Total award: $200.000

“Predictive Factors for Cognitive Outcome after Bilateral Subthalamic Nucleus Deep Brain Stimulation

for Parkinson Disease”

Role: Primary Investigator

Sponsor N/A 9/12 - Current

Olga Klepitskaya, MD (PI) Total Award: N/A

“An Objective Double-Blind Evaluation of Bupropion and Citalopram in an Individual with Friedreich

Ataxia”

Role: Primary Investigator

Bibliography:

Peer-reviewed Articles: 1. Klepitskaya OS. Shishmakov, YV. Biological Activity of Pine-Tree Oil. Questions of the

Ecological Biochemistry and Physiology;1988: 45-49 Article in Russian

2. Klepitskaya OS, Ottieva EN. Neurological Disorders in Patients with Lupus Erythematosus.

Far Eastern Medical Journal;1998(2):67-68 Article in Russian

3. Klepitskaya OS, Rykova MG. Modern Clinical Variations of Conversion Disorder. Topics in

Psychopathology. Publication of the Russian Institute of Mental Diseases named after

Serbskiy;1998:22-28 Article in Russian

4. Goetz, C.G., Tilley, B.C., Shaftman, S.R…. Klepitskaya, O….et. al. Movement Disorder

Society-Sponsored Revision of the Unified Parkinson's Disease Rating Scale (MDS-UPDRS):

Scale presentation and clinimetric testing results. Movement Disorders. 2008; 23 (15): 2129 -

2170

5. Kluger BM, Klepitskaya O, Okun MS. Surgical Treatment of Movement Disorders. Neurologic

Clinics of North America; 2009:633-677

6. Patel SG, Stickrath CR, Anderson M, Klepitskaya O. How Should Parkinson’s Disease be

Managed Perioperatively? The Hospitalist. 2010;15(6):19-22

http://www.thehospitalist.org/details/article/704937/How_should_Parkinsons_disease_be_mana

ged_perioperatively.html

7. Spielman J, Mahler L, Halpern, A., Gilley P, Klepitskaya O, Ramig L. Intensive Voice

Treatment (LSVT®LOUD) for Parkinson's disease following Deep Brain Stimulation of the

Subthalamic Nucleus. Journal of Communication Disorders. 2011;

doi:10.1016/j.jcomdis.2010.05.003

8. Klepitskaya OS, Cole W, Henderson J, Bronte-Stewart H. Deep Brain Stimulation in “On”-

Parkinson Hyperpyrexia. Neurology. 2011;76(7): s69-s71

9. Hall D, Klepitskaya O, Leehey M. Fragile X-Associated Tremor Ataxia Syndrome in FMR1

Gray Zone Allele Carriers. Movement Disorders. 2011;27(2):297-301

10. Klepitskaya O, Neuwelt AJ, Nguyen TM, Leehey M. Primary Dystonia Misinterpreted as

Parkinson Disease: A Case Presentation and Practical Clues. Neurology. (In Press, October 2013.)

Book Chapters:

1. Klepitskaya O. Parkinsonism- Hyperpyrexia syndrome. In: Kompoliti K, and Verhagen Metman

L (eds.) Encyclopedia of Movement disorders. 2010; vol. 1, pp. 399-401 Oxford: Academic Press.

2. Klepitskaya O. Dopamine Dysregulation syndrome. In: Kompoliti K, and Verhagen Metman L.

(eds.) Encyclopedia of Movement disorders. 2010; vol. 1, pp. 323-326 Oxford: Academic Press.

3. Berk J, Klepitskaya O. Thalamotomy. In: Mechanisms and emerging therapies of tremor

disorders. New York: Springer; 2013(24):431-461

4. Klepitskaya O. Restless Leg Syndrome. In: Barton B and Hall D (eds.) Non-Parkinsonian

Movement Disorders. 2013; Oxford: Wiley-Blackwell (in print)

Scientific Abstracts and Poster Presentations (competitive):

1. Klepitskaya OS, Maa EH, Tyler KL. Delayed Seroconversion in Immunocompromised Patient

with West Nile Virus-Associated Brainstem Encephalitis. 57th Annual Meeting of the American

Academy of Neurology, April 2005, Miami, Fl, USA

2. Klepitskaya OS, Proskokova TN. Hepatolenticular Degeneration: Wilson- Konovalov’s Disease.

58th Annual Meeting of the American Academy of Neurology, April 2006, San Diego, CA, USA

Neurology;2006(66):A2

3. Grenier Y, Spielman JL, Klepitskaya OS, Ramig LO, Henderson JM, Bronte-Stewart HM.

Methodology for objective motor speech assessment outcome after deep brain stimulation for

Parkinson’s disease. 10th International Movement Disorders Congress, Kyoto, Japan, October

2006 Movement Disorders;2006(21):S655

4. Klepitskaya OS, Cole WL, Bronte-Stewart HM Evolution of Parkinson disease during 4 years

of Deep Brain Stimulation: a case report. 10th International Movement Disorders Congress,

Kyoto, Japan, October, 2006 Movement Disorders;2006(21):S665

5. Klepitskaya OS, Fischbein NJ, Hall DA, Bronte-Stewart HM. Superficial Siderosis with

supranuclear palsy, parkinsonism and falls. 10th International Movement Disorders Congress,

Kyoto, Japan, October, 2006 Movement Disorders;2006(21):S525- S526

6. Klepitskaya OS, Cole WL, Henderson JM, Bronte-Stewart HM. Deep brain stimulation

decreases the risks for Parkinsonism-Hyperpyrexia syndrome and suppresses levodopa-induced

dyskinesias: a case report. 10th

International Movement Disorders Congress, Kyoto, Japan,

October, 2006.Movement Disorders;2006(21):S666-S667 and Annual meeting of Parkinson

Study Group, Chicago IL, USA, 2006 Movement Disorders;2006(21):1552

7. Richardson MS, Ojemann SG, Klepitskaya OS. Response of the subthalamic nulcleus neurons

to vocalization. 11th

International Movement Disorders Congress, Istanbul, Turkey, June

2007.Movement Disorders;2007(22):S53 and 1st international symposium “Basal ganglia speech

disorders and Deep Brain Stimulation,” July 2007, London, UK

8. Klepitskaya OS, Kim Z, Richardson MD, Ojemann SG. Three-dimensional computerized

model of subthalamic nucleus. 12th

International Movement Disorders Congress, Chicago, IL,

USA, June 2008.Movement Disorders;2008(23):S108 – Poster was selected for guided poster

tour

9. Klepitskaya O, Kumar R. Efficacy and Safety of Low Level Electromagnetic Fields Treatment

in Parkinson’s Disease. Annual meeting of Parkinson’s Study Group, Salt Lake City, UT, USA.

Movement Disorders;2008(11):1633

10. Klepitskaya OS, Fowler JJ, Kluger BM, Ojemann SG. Number of microelectrode recording

passes during bilateral staged vs. unstaged deep-brain stimulation surgery for Parkinson's disease.

13th International Movement Disorders Congress, Paris, France, June 2009. Movement

Disorders;2009(24):S485-S486

11. Klepitskaya OS, Koop MM, Bronte-Stewart HM. Longitudinal study of Microlesion Effect on

Bradykinesia after Subthalamic Nucleus Deep Brain Stimulation Surgery for Parkinson's disease.

13th International Movement Disorders Congress, Paris, France, June 2009 Movement

Disorders;2009(24):S485

12. Reid KA, Hoyt B, Tanabe J, Ojemann SG, Legenska A, Klepitskaya OS. Prevalence of

dopamine dysregulation syndrome in Parkinson’s disease patients-candidates for deep brain

stimulation. 14th

International Movement Disorders Congress, Buenos Aires, Argentina, June

2010 Movement Disorders;2010(25):S282

13. Klepitskaya OS, Hoyt B, Berk JJ, Ojemann SG. Reversible cognitive impairment induced by

deep brain stimulation of subthalamic nucleus. 14th

International Movement Disorders Congress,

Buenos Aires, Argentina, June 2010 Movement Disorders;2010(25):S446

14. Pelak VS, Choi M, Jung S, Halliday B, Hager E, Klepitskaya O, Ojemann S, Filley C, Dubin M.

“Visuospatial Assessment By Virtual 3D Radial Optic Flow Illusion In Healthy Aging, Mild

Alzheimer’s Disease (AD), And Pre-Deep-Brain Stimulation (DBS) Parkinson’s Disease (PD)

Subjects.” Abstract A-316-0002-01523. 10th Annual International Conference on Alzheimer’s

and Parkinson’s Disease. Barcelona, Spain. March 9-13th, 2011

15. Hall D, Klepitskaya OS, Tassone F, Spector E, Leehey M. FXTAS in Patients with Fragile X

Gray Zone Alleles. 63rd

Annual AAN Meeting, Honolulu, Hawaii, March 2011. Neurology;

2011(76)9:SA399

16. O.S. Klepitskaya, Z. Kim, S.G. Ojemann. Mock microelectrode recording is undistinguishable

from a real time recording in sham surgery controlled clinical trial of new surgical treatment for

Parkinson’s disease [Abstract 221]. Movement Disorders; 2011;26(Suppl 2): page S73

17. Ragole T, Michas-Martin A, Moss A, Juarez-Colunga E, Klepitskaya O. “Review of published

outcomes of subthalamic nucleus deep brain stimulation in Parkinson disease supports hypothesis

of disease-modifying effect.” 2013 Movement Disorders;2013(25):1316, 25th

Annual meeting of

Parkinson’s Study Group & 27th

Annual PSG Symposium, Montreal, Canada.