Vol. 268, No. 13 The Journal of May 5, 1993

Biological Chemistry Copyright 0 1993 by the American Society for Biochemistry and Molecular Biology, Inc.

428 East Preston St., Baltimore, MD 21202 USA.

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CONTENTS*

MINIREVIEW 9230

with GAP exchange factors, and its biological effector Structural requirements for the interaction of p21’”

target. Paul Polakis and Frank McCormick

COMMUNICATIONS 9238

The substance P receptor, which couples to Gull, is a

Madan M. Kwatra, Debra A. Schwinn, Jolanda Schreurs, substrate of &adrenergic receptor kinase 1 and 2.

Jonathan L. Blank, Chong M. Kim, Jeffrey L. Benouic, James E. Krause, Marc G. Caron, and Robert J . Lefkowitz

Hepatocyte growth factor/scatter factor stimulates the

Daniela Gramaglia, Pa010 dalla Zonca, and Paolo M. Comoglio Ras-guanine nucleotide exchanger. Andrea Graziani, 9255

Regulation of ~ 5 6 ~ ~ kinase expression and control of DNA synthesis in activated human B lymphocytes. Joelle Taieb, Isabelle Vitte-Mony, Marie Therese Auffredou, Oliuier Dorseuil, Gerard Gacon, Jacques Bertoglio, and Aime

9246

9262

V ~ 9 u e Z

The Wilms’ tumor gene product WT1 activates or sup- presses transcription through separate functional do- mains. Zhao- Yi Wang, Qing-Qing Qiu, and Thomas F. Deuel

Transmembrane signaling by epidermal growth factor receptors lacking autophosphorylation sites. Stuart J. Decker

A keratinocyte growth factor receptor-derived peptide

Donald P. Bottaro. Emma Fortney, Jeffrey S. Rubin, and antagonist identifies part of the ligand binding site.

Stuart A. Aaronson

The coated vesicle vacuolar (H+)-ATPase associates with and is phosphorylated by the 50-kDa polypeptide of the clathrin assembly protein AP-2. Melanie Myers and Michael Forgac

Insulin action on the internalization of the GLUT4

P. Czech and Joanne M. Buxton glucose transporter in isolated rat adipocytes. Michael

Presteady state kinetics of an S-adenosylmethionine- dependent enzyme. Evidence for a uniaue binding ori-

9267

9275

9280

9287

Isolation and primary structure of the three major forms of granulin-like peptides from hematopoietic tis- sues of a teleost fish (Cyprinus carpio). Daniel R. Bel- court, Claude Lazure, and Hugh P. J . Bennett

Escherichia coli thioesterase I, molecular cloning and sequencing of the structural gene and identification as a periplasmic enzyme. Hyeseon Cho and John E. Cronun, Jr.

Binding of mutants of human insulin-like growth factor I1 to insulin-like growth factor binding proteins 1-6. Leon A. Bach, Susan Hsieh, Katsu-ichi Sakano, Hiroyuki Fu- jiwara, James F. Perdue, and Matthew M. Rechler

Ceramide-mediated growth inhibition and CAPP are conserved in Saccharomyces cerevisiae. Julie D. Fish- bein, Rick T. Dobrowsky, Alicja Bielawskn, Stephen Garrett, and Yusuf A. Hannun

Antagonist-occupied human progesterone receptors bound to DNA are functionally switched to transcrip- tional agonists by CAMP. Carol A. Sartorius, Lin Tung, Glenn S. Takimoto, and Kathryn B. Horwitz

Role of the fusion peptide sequence in initial stages of influenza hemagglutinin-induced cell fusion. Christian Schoch and Robert Blumenthal

Molecular characterization of the gene encoding the y subunit of the human skeletal muscle l,4-dihydropyri- dine-sensitive Caz+ channel (CACNLG), cDNA se- quence, gene structure, and chromosomal location. Pa- tricia A. Powers, Shuying Liu, Kirk Hogan. and Ronald G. Gregg

Stimulation of human neutrophils by 5-oxo-6,8,11,14- eicosatetraenoic acid by a mechanism independent of the leukotriene B4 receptor. William S. Powell, Syloie Grauel, R. John MacLeod, Elaine Mills, and Mandana Hashefi

Differences in substrate specificities of a and j 3 platelet- derived growth factor (PDGF) receptors. Correlation with their ability to mediate PDGF transforming func- tions. Mohammad A. Heidaran, John F. Beeler, Jin-Chen Yu,

and Stuart A. Aaronson Toshio Ishibashi, William J. LaRochelle, Jacalyn H. Pierce,

entation requirement for EcoRI DNA methyltragsfer- ase. Norbert 0. Reich and Neda Mashhoon

Selective inhibition of protein kinase C isozymes by the indolocarbazole GO 6976. Geore Martinv-Bafin. Marceln .Inn Trnnmnn

9296 Two different, overlapping pathways of transcription initiation are active on the TATA-less human androgen receptor promoter. The role of Spl . Peter W. Faber, Henri C. J . uan Rooij, Helma J . Schipper, Albert 0. Brinkmann, and

G. Kazanietz, Harald Mischak, peter M. “BlurnberE. Georp ~ I . I - .Y..”-l”

Koch, Hubert Hug, Dieter Marme, and Christoph Sch&htele-

ARTICLES Characterization of retinol metabolism in cultured hu- man epidermal keratinocytes. R. Keith Randolph and Mar- cia Simon

Molecular cloning and analysis of the NAG1 cDNA coding for glucosamine-6-phosphate deaminase from Candida albicans. Krishnamurthy Natarajan and Asis Datta

Trypanosome metabolism of myristate, the fatty acid

brane anchor. Tamara L. Doering, Melissa S. Pessin, Eleanor required for the variant surface glycoprotein mem-

F. Hoff, Gerald W. Hart, Daniel M. Ruben, and Paul T. Englund

9302 Glycoprotein recycling to the galactosyltransferase compartment of the Golgi complex. Kristen M. H u n g and Martin D. Snider

9311 Amino/carboxyl-terminal deletion mutants of human choriogonadotropin 8. Jianing Huang, Fang Chen, and David Puett

9316 Identity elements of tRNATw. Identification and evo- lutionary conservation. Hong Xue, Wenyan Shen, Richard Giege, and J . Tze-Fei Wong

9323 The interaction of illimaquinone, a selective inhibitor

of human immunodeficiency and murine leukemia of the RNase H activity, with the reverse transcriptases

retroviruses. Shoshana Loya and Amnon Hizi

9223 Effect of low molecular weight aliphatic alcohols and 9329 Analysis of gas vesicle gene expression in Haloferax

ation. Yingqing Yang, Sharon Barker, Mu Jung Chen, and related compounds on platelet factor 4 subunit associ- mediterranei reveals that GvpA and GvpC are both gas

Kevin H. Mayo vesicle structural proteins. Christoph Englert and Felicitas Pfeifer

* The CONTENTS arranged by Subject Categories will be found immediately following these CONTENTS. Full Instructions to Authors will be found in (1993) J . Biol. Chem. 268, 745-753, and reprints may be obtained from the editorial office.

iii

V

9337 Kinetic characterization of a &glucosidase from a 9448 yeast, Candida wickerhamii. Shelby N. Freer

9343 Phosphate affects the distribution of flux control among the enzymes of oxidative phosphorylation in rat skeletal muscle mitochondria. Elke Wisniewski, Wolfram S. Kunz, and Frank Norbert Gellerich 9466

9347 Protein kinase C and protein tyrosine kinase activity contribute to mitogenic signaling by endothelin-1.

pp60"". Michael S. Simonson and William H. Herman Cross-talk between G protein-coupled receptors and

9473 9358 Temperature-sensitive mutations in the phage P22 coat

protein which interfere with polypeptide chain folding. Carl L. Gordon and Jonathan King

9369 Low density lipoprotein receptor internalizes low den- sity and very low density lipoproteins that are bound

Monique Mulder, Paola Lombardi, Hans Jansen, The0 J. C. to heparan sulfate proteoglycans via lipoprotein lipase.

van Berkel, Rune R. Frants, and Louis M. Hauekes

9376 A novel form of cytochrome P-450 family 4 in human polymorphonuclear leukocytes. cDNA cloning and

Kikuta, Emi Kusunose, Katsuya Endo, Satoru Yamamoto, expression of leukotriene B, w-hydroxylase. Yasushi

Kazuhiro Sogawa, Yoshiaki Fujii-Kuriyama, and Masamichi Kusunose

9381 Isolation and characterization of the chains of type V/

Mayne, Randolph G. Brewton, Pauline M. Mayne, and John type XI collagen present in bovine vitreous. Richard

R. Baker

9387 Identification of a novel serum and growth factor-in- ducible gene in vascular smooth muscle cells. Ping Feng and Gene Liau

9393

9400

9405

9410

9416

9425

9430

9437

Spermidine-induced destabilization of ornithine decar- boxylase (ODC) is mediated by accumulation of anti- zyme in ODC-overproducing variant cells. Ryuhei Kan- amoto, Takaaki Kameji, Shintaro Iwashita, Kazuei Igarashi, and Shin-ichi Hayashi

Characterization of mutant rhodopsins responsible for autosomal dominant retinitis pigmentosa. Mutations on the cytoplasmic surface affect transducin activation. K. Christopher Min, Tatyana A. Zvyaga, Aaron M. Cypess, and Thomas P. Sakmar

Chemotaxis of the marine bacterium Vibrio furnissii to sugars. A potential mechanism for initiating the chitin catabolic cascade. Charles Yu, Bonnie L. Bassler, and Saul Roseman

Mutants of Rab3A analogous to oncogenic Ras mutants.

Rab3A-guanine nucleotide releasing factor. William H. Sensitivity to Rab3A-GTPase activating protein and

Brondyk, Colleen J . McKiernan, Ethan S. Burstein, and Ian G. Macara

mutant with defects in phosphatidylinositol-specific Characterization of a second hamster lung fibroblast

phospholipase C. Mike A. Leonis and David F. Silbert

Calmodulin-dependent nitric-oxide synthase. Mecha- nism of inhibition by imidazole and phenylimidazoles. Donald J . Wolff, George A. Datto, Raymond A. Samatouicz, and Richard A. Tempsick

The dual mode of inhibition of calmodulin-dependent

Donald J. Wolff, George A. Datto, and Raymond A. Samatouicz nitric-oxide synthase by antifungal imidazole agents.

A variant of exotoxin A that forms potent and specific chemically conjugated immunotoxins. G. Jilani Chaudry, R. Jerrold Fulton, and Rockford K. Draper

Organization and nucleotide sequence of the Bacillus subtilis diaminopimelate operon, a cluster of genes en- coding the first three enzymes of diaminopimelate syn- thesis and dipicolinate synthase. Nai- Yong Chen, Shu-Qin Jiang, Donald A. Klein, and Henry Pau1u.s

Isolation of a human liver fructose-l,6-bisphosphatase cDNA and expression of the protein in Escherichia coli.

El-Maghrabi, Madhaui Gidh-Jain, LeeAnn R. Austin, and Si- Role of Asp-118 and Asp-121 in catalysis. M. Raafat

mon J. Pdkw

The MglA component of the binding protein-dependent galactose transport system of Salmonella typhimurium is a galactose-stimulated ATPase. Gilbert Richarme, Ab- delhamid El Yaagoubi, and Masamichi Kohiyama

9478 Phosphoinositide 3-kinase is activated by phosphopep- tides that bind to the SH2 domains of the 85-kDa sub- unit. Christopher L. Carpenter, Kurt R. Auger, Manas Chan- udhuri, Monique Yoakim, Brian Schaffhawen, Steven Shoel- son, and Lewis C. Cantley

9484 Purification and properties of 2'-hydroxybenzalpyru- vate aldolase from a bacterium that degrades naphtha- lenesulfonates. Andrea E. Kuhm, Hans-Joachim Knack- muss, and Andreas Stolz

9490 Expression of dopamine @-hydroxylase in Drosophila Schneider 2 cells. Evidence for a mechanism of mem- brane binding other than uncleaved signal peptide. Karen R. Gibson, Philip G. Vanek, William D. Kaloss, G. Bruce Collier, John F. Connaughton, Monica Angelichio, George P. Liui, and Patrick J. Fleming

9496 Differences in the properties and enzymatic specifici- ties of the two active sites of angiotensin I-converting enzyme (kininase 11). Studies with bradykinin and other natural peptides. Emmanuel Jaspard, Lei Wei, and Franpis Alhenc-Gelas

9504

9511

9517

9522

9526

9533

9541

9548

The 5' and 3' untranslated regions of satellite tobacco necrosis virus RNA affect translational efficiency and dependence on a 5' cap structure. Richard T. Timmer, Lisa A. Benkowski, David Schodin, Sandra R. Lax, Anneke M. Metz, Joanne M. Ravel, and Karen S. Browning

Effects of truncation of human Pro-tumor necrosis fac- tor transmembrane domain on cellular targeting. To- shihiko Utsumi, Alla Leuitan, Mien-Chie Hung, and Jim Klostergaard

Different COOH-terminal domains determine sensitiv- Two isoforms of prostaglandin E receptor EP3 subtype.

ity to agonist-induced desensitization. Manabu Negishi,

Ichikawa Yukihiko Sugimoto, Atswhi Irie, Shuh Narumiya, and Atsushi

High-level and erythroid-specific expression of human glucose-6-phosphate dehydrogenase In transgenic mice. Tang K. Tang, Ka-Bik Tam, and See-Chang Huang

Tumor necrosis factor-cy induces expression of mono- cyte chemoattractant J E via fos and jun genes in clonal osteoblastic MC3T3-El cells. Shigemasa Hanazawa, Akira

azuka, Hideo Katoh, and Shigeo Kitano Takeshita, Shigeru Amano, Toshihiko Semba, Tadanobu Nir-

Complex patterns of sequence variation and multiple

erythroid ankyrin gene. Connie S. Birkenmeier, Robert A. 5' and 3' ends are found among transcripts of the

White, Luanne L. Peters, Elaine J. Hall, Samuel E. Lux, and Jane E. Barker

Identification and purification of a novel serine pro-

H. Salem teinase inhibitor. Paul B. Coughlin, Tim Tetaz, and Hatem

Tyrphostin inhibits bombesin stimulation of tyrosine phosphorylation, c-fos expression, and DNA synthesis in Swiss 3T3 cells. Michael Seck1 and Enrique Rozengurt

9442 Charged residues render pro-OmpA potential depend- ent for initiation of membrane translocation. Bruce Geller, Heng- Yi Zhu, Shiyuon Cheng, Andreas Kuhn, and Ross E. Dalbey Kahn

9555 Activation of ADP-ribosylation factor by Golgi mem- branes. Evidence for a brefeldin A- and protease-sen- sitive activating factor on Golgi membranes. Paul A. Randazzo, Yun Chung Yang, Cherrie Rulka, and Richard A.

vi

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9585

9593

9604

9611

962 1

9629

9636

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9653

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9667

9675

9681

9690

9702

9709

Direct evidence for tyrosine and threonine phosphoryl- ation and activation of mitogen-activated protein ki- nase by vasopressin in cultured rat vascular smooth muscle cells. Yosef Granot, Eleanor Erikson, Hagit Fridman,

James L. Maller Vicki Van Putten, Bryan Williams, Robert W. Schrier, and

Inhibition of glycosylphosphatidylinositol biosynthesis in Leishmania mexicana by mannosamine. Mark C. Field, Enrque Medina-Acosta, and George A. M. Cross

Purification and characterization of DNA helicase 111 from the yeast Saccharomyces cerevisiae. Kikun Shimizu and Akio Sugino

Interaction with newly synthesized and retained pro- teins in the endoplasmic reticulum suggests a chaperone function for human integral membrane protein IPSO (calnexin). Vwlaine David, Frans Hochstenbach, Sumatz Ra- jagopalan, and Michael B. Brenner

Induction of peroxisomal fatty acid &oxidation and liver fatty acid-binding protein by peroxisome prolif- erators. Mediation via the cytochrome P-450IVA1 W -

hydroxylase pathway. Raja M. Kaikaus, William K. Chan, Nina Lysenko, Rupsa Ray, Paul R. Ortiz de Montellano, and Nathan M. Bass

The calmodulin-binding domain of the mouse 90-kDa heat shock protein. Yasufumi Minumi, Hiroshi Kawasaki, Koichi Suzuki, and Ichiro Yahara

Long term growth factor exposure and differential ty- rosine phosphorylation are required for DNA synthesis in BALBIc 3T3 cells. Xi Zhan, Xiaoguo Hu, Robert Friesel, and Thomas Maciag

Identification of a soluble receptor for platelet-derived growth factor in cell-conditioned medium and human plasma. Jay Tiesman and Charles E. Hart

Wild type GAL4 binds cooperatively to the GALI-10 UASa in vitro. Tim Kang, Tim Martins, and Ivan Sadowski

Locations and immunoreactivities of phosphorylation sites on bovine and porcine tau proteins and a PHF-tau fragment. Linda Poulter, Derek Barratt, Clay W Scott, and Claudia B. Caput0

Expression and role of c-myc in chondrocytes undergo- ing endochondral ossification. Masahiro Iwamoto, Kimi-

Petropoulos, Donald L. Ewert, and Maurczio Pacifici toshi Yagami, Phyllis Lu Valle, Bjorn R . Olsen, Christos J.

Lysosomal accumulation of unesterified cholesterol in model macrophage foam cells. Rajendra K. Tangirala, Flor- ence H. Mahlberg, Jane M. Glick, W. Gray Jerome, and George H. Rothblat

Macrosialin, a mouse macrophage-restricted glycopro- tein, is a member of the lamp/lgp family. Claire L. Hol- ness, Rosangela P. da Silva, Jonathan Fawcett, Siamon Gordon, and David L. Simmons

Regulation of purified subtypes of phosphatidylinosi- tol-specific phospholipase C f l by G protein a and BY subunits. Alan V. Smrcka and Paul C. Sternwels

High level expression of mammalian protein farnesyl- transferase in a baculovirus system. The purified pro- tein contains zinc. Wen-Jr Chen,,John F. Moomaw, Luurze Overton, Thomas A. Kost, and Patrrck J. Casq

Cloning, sequencing, distribution, and expression in Escherichia coli of flavin-containing monooxygenase

Emmanuel Atta-Asafo-Adjer, Michuel P. Lawton, and Rrchard 1C1. Evidence for a third gene subfamily in rabbits.

M. Philpot Eukaryotic topoisomerase I-mediated cleavage re- quires bipartite DNA interaction. Cleavage of DNA substrates containing strand interruptions implicates a role for topoisomerase I in illegitimate recombipation.

dersen, and Ole Westergaard Kent Christiansen, A. Barbara Dirac Sueptrup, Ann2 H. An-

Multiple endoglycosidase F activities expressed by Fh- vobacterium meningosepticum endoglycosidases F2 and Fs. Molecular cloning, primary sequence, and en; zyme expression. Anthony L. Tarentino, Geraldine Quz- nones, Li-Ming Changchien, and Thomas H. Plummer, Jr.

Use of endoproteases to identify catalytic domains,

peptidylglycine a-amidating monooxygenase. E. Jean linker regions, and functional interactions in soluble

Husten, Francisco A. Tausk, Henry T. Keutmann, and Betty A. Eipper

9718

9725

9730

9737

9747

9753

9762

9771

9780

9787

9793

9803

9811

9817

9824

9839

9847

9856

Regulation of glycosylphosphatidylinositol biosyn- thesis by GTP. Stimulation of N-acetylglucosamine- phosphatidylinositol deacetylation. Victoria L. Stevens

partic acid in vitronectin abolishes cell adhesion. Rich- Site-directed mutagenesis of the arginine-glycine-as-

ard C. Chery , Marilyn A. Honan, and Perumal Thiagarajan

Identification of a promoter element which participates in CAMP-stimulated expression of human insulin-like

Laura A. DePaolis, Phillip D. K. Lee, and David R. Powell growth factor-binding protein-1. Adisak Suwanichkul,

The glutathione S-transferase D genes. A divergently organized, intronless gene family in Drosophila mela- nogwter. Yann-Pyng S. Toung, Tao-shih Hsieh, and Chen-Pei D. Tu

Insulin induces the phosphorylation of nucleolin. A pos- sible mechanism of insulin-induced RNA efflux from nuclei. Peter Csermely, Tam& Schnaider, Bentley Cheatham, Mark 0. J. Olson, and C. Ronald Kahn

Molecular analysis of human B-arrestin-1: cloning, tis- sue distribution, and regulation of expression. Identi- fication of two isoforms generated by alternative splic- ing. Giustino Parruti, Francesca Peracchia, Michele ,Sallese,

Antonio De Blasi Grazia Ambrosini, Mariateresa Masini, Domencco Rotrlro, and

A transgenic mouse model for studying the lineage relationships and differentiation program of type I1 pneumocytes at various stages of lung development. J . Randall Hansbrough, Steven M. Fine, and Jeffrey I. Gordon

Mapping of neutralizing epitopes and the receptor bind- ing site of human interleukin 18. Philip L. Simon, Vasant Kumar, Jay S. Lillquist, Pradip Bhatnogar, Richard Einstein, John Lee, Terence Porter, David Green, Ganesh Sathe, and Peter R. Young

Kinetics of thrombin receptor cleavage on intact cells. Relation to signaling. Kenji Ishii, Lutz Hein, Brian Kobilka, and S h u n R. Coughlin

The three-dimensional structure of the ligand-binding domain of a wild-type bacterial chemotaxis receptor. Structural comparison to the cross-linked mutant forms and conformational changes upon ligand binding. Joanne I. Yeh, Hans-Peter Biemann, Jayvardhan Pundit, Daniel E. Koshlnnd, and Sung-Hou Kim

Template-directed pausing of DNA synthesis by HIV-1

sequences in vitro. George J. Klarmann, Cherylene A. reverse transcriptase during polymerization of HIV-1

Schauber, and Bradley D. Preston

Co-regulation of the mitogen-activated protein kinase, extracellular signal-regulated kinase 1, and the 90- kDa ribosomal Sf3 kinase in PC12 cells. Distinct effects of the neurotrophic factor, nerve growth factor, and the mitogenic factor, epidermal growth factor. Tien T. Nguyen, Jean-Claude Scimeca, Chantal Filloux, Pascal Peraldi, Jean-Louis Carpentier, and Emmanuel Van Obberghen

Interaction between staphylokinase, plasmin(ogen), and a2-antiplasmin. Recycling of staphylokinase after neutralization of the plasmin-staphylokinase complex by az-antiplasmin. Karen Silence, Desire Collen, and H. Roger Lijnen

Rapid agonist-mediated phosphorylation of m3-mus- carinic receptors revealed by immunoprecipitation. An- drew B. Tobin and Stefan R. Nahorski

Evidence for involvement of the voltage-dependent Na+ channel gating in depolarization-induced activation of G-proteins. Mako Cohen-Armon and Mordechai Sokolovsky

Hormonal/metabolic regulation of the human GLUT4/ muscle-fat facilitative glucose transporter gene in transgenic mice. Ann Louise Olson, Min-Ling Liu, W. Scott Moye-Rowley, John B. Bwe, Graeme I. Bell, and Jeffrey E. Pessin

Microtubule-associated protein 2 alters the dynamic properties of microtubule assembly and disassembly. Richard J. Kowalski and Robley C. Williams, Jr .

Deficient expression of decorin in infantile progeroid patients. Lesley A. Beauan, Edelgard Quentin-Hoffmann, Elke ScMnherr, Friedemann Snigula, Jules G. Leroy, and Hans Kresse

vii

9863 A high affinity conformational state on VLA integrin heterodimers induced by an anti-& chain monoclonal

cisco Sanchez-Madrid antibody. Alicia G. Arroyo, Angeles Garcia-Pardo, and Fran-

9869 CAMP-dependent rotein kinase re resses myogenic differentlation anz the activity of tge muscle-specific helix-loop-helix transcription factors Myf-5 and MyoD. Barbara Winter, Thomas Braun, and H a m Henning Arnold

9879 Neural ex ression of a novel alternatively s liced and

J . Mutchler Brian E. Sullivan, Thomas M. Lunigan, Mrchael polyadenyyated Gsa transcript. J. Adam Crawgrd, Kendra

S. Clark, a& Andrew F. Russo 9886 Enzymatic characterization of &D-gal?ctoside a2,3-

James. P. Doom, Marma Ehuenkova, Ian D. Manger, and trans-sialidase from , T r y anoaorna crwt. Peter Scudder,

Miercro E. A. Pereira 9892 The specific association of a phos hofructokinase iso-

pase As. Im Ecations for the coordinated regulation of form with m ocardial calcium-ingpendent phospholi-

hospholi oqysis and glycolysis. Stanley L. Hazen and kchard w”cross

9901 Interactions between the bone matrix proteins ostep- pontin and bone sialoprotein and the osteoclast mte rm a d s potentiate bone resorption. F. Patrick Ross, 5ean

Mary 6. Farach-Carson, Kerth A. Mrntz, Pamela Gehron Chappel Jose I . Alvarez, Diane Sander, William T . Butler,

Robey, Steven L. Tertelbaum, and Davld A. Cheresh

9908 Mutational analysis of the Golgi retention signal of bovine @-1,4-galactosyltransferase. Arni S. Masibay, Pe- tety V. Balaji, Elizabeth E. Boeggemnn, and Pradmnn K. Qasba

9917 Analysis of the tissue-specific promoter of the MUCl gene. Ales Kovarik, Nigel Peat, David Wilson, Sandra J. Gendler, and Joyce Taylor-Papadimitriou

9927 Characterization of endomannosidase inhibitors and evaluation of their effect on N-linked oligosaccharide processing during glycoprotein biosynthesis. Sen Hirai- zuml, Ulrlke Spohr, and Robert G. Spiro

ADDITIONS AND CORRECTIONS

9936 Evidence that both Ca’+-specific sites of skeletal muscle TnC are required for full activity. Vol. 265 (1990) 21554-21560. Zelin Sheng, William L. Strauss, Jean-Marie Francois, and James D. Potter

9936 Hexokinase I1 mRNA and gene structure, regulation by

Richard L. Printz, Stephen Koch, Lincoln R. Potter, Robert M . insulin, and evolution. Vol. 268 (1993) 6209-5219.

Granner O‘Doherty, James J . Tiesinga, Sylviane Moritz, and Dory1 K .

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Vol. 268, No. 13 The Journal of Biological Chemistry May 5,1993

CONTENTS Arranged by Subject Categories

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MINIREVIEW 9369 Low density lipoprotein receptor internalizes low den- sity and very low density lipoproteins that are bound to heparan sulfate proteoglycans via lipoprotein lipase. Monique Mulder, Paola Lombardz, Hans Jansen, The0 J. C. uan Berkel, Rune R. Frants, and Louis M. Havekes

Structural requirements for the interaction of p21" with GAP exchange factors, and its biological effector target. Paul Polakis and Frank McCormick

CARBOHYDRATES, LIPIDS, AND OTHER NATURAL PRODUCTS

Trypanosome metabolism of myristate, the fatty acid required for the variant surface glycoprotein mem- brane anchor. Tamara L. Doering, Melissa S. Pessin, Eleanor F. Hoff, Gerald W. Hart, Daniel M. Ruben, and Paul T. Englund

Ceramide-mediated growth inhibition and CAPP are conserved in Saccharomyces cereuisiae. Julie D. Fish- bein, Rick T. Dobrowsky, Alicia Bielawska, Stephen Garrett, and Yusuf A. Hannun

Chemotaxis of the marine bacterium Vibrio furnissii to sugars. A potential mechanism for initiating the chitin catabolic cascade. Charles Yu, Bonnie L. Basskr, and Saul Roseman

Inhibition of glycosylphosphatidylinositol biosynthesis

Field, Enrique Medina-Acosta, and George A. M. Cross in Leishmania mexicana by mannosamine. Mark C.

Regulation of glycosylphosphatidylinositol biosyn- thesis by GTP. Stimulation of N-acetylglucosamine- phosphatidylinositol deacetylation. Victoria L. Steuens

Characterization of endomannosidase inhibitors and evaluation of their effect on N-linked oligosaccharide processing during glycoprotein biosynthesis. Sen Hirai- Zuni, Ulrike Spohr, and Robert G. Spiro

CELL BIOLOGY AND METABOLISM Hepatocyte growth factorlscatter factor stimulates the Ras-guanine nucleotide exchanger. Andrea Graziani, Daniela Gramaglia, Paolo dalla Zonca, and Paolo M. Comoglio

Regulation of ~56"' kinase expression and control of DNA synthesis in activated human B lymphocytes. Joelle Taieb, Isabelle Vztte-Mony, Marie Therese Auffredou, Oliuier Dorseuil. Gerard Gacon, Jacques Bertoglio, and Aime Vazquez

Transmembrane signaling by epidermal growth factor

Decker receptors lacking autophosphorylation sites. Stuart J.

Insulin action on the internalization of the GLUT4

P. Czech and Joanne M. Buxton glucose transporter in isolated rat adipocytes. Michael

Characterization of retinol metabolism in cultured hu- man epidermal keratinocytes. R. Keith Randolph and Mar- cia Simon

Antagonist-occupied human progesterone receptors bound to DNA are functionally switched to transcrip- tional agonists by CAMP. Carol A . Sartorius, Lin Tung, Glenn S. Takimoto, and Kathryn B. Horwitz

Stimulation of human neutrophils by 5-oxo-6,8,11,14-

the leukotriene B, receptor. William S. Powell, Syluie eicosatetraenoic acid by a mechanism independent of

Grauel, R. John MacLeod, Elatne Mills, and Mandana Hashefi

Differences in substrate specificities of a and fi platelet- derived growth factor (PDGF) receptors. Correlation with their ability to mediate PDGF transforming func- tions. Mohammad A. Heidaran, John F. Beeler, Jin-Chen Yu, Toshio Ishibashi, William J . LuRochelle, Jacalyn H. Pierce, and Stuart A. Aaronson

Glycoprotein recycling to the galactosyltransferase compartment of the Golgi complex. Kristen M. Huang and Martin D. Snzder

9347 Protein kinase C and protein tyrosine kinase activity contribute to mitogenic signaling by endothelin-1. Cmaa-talk hetween G urotein-couuled receotors and

9393

9416

9437

9478

9490

951 1

9517

9526

9548

9555

Spermidine-induced destabilization of ornithine decar- boxylase (ODC) is mediated by accumulation of anti- zyme in ODC-overproducing variant cells. Ryuhei Kan-

and Shin-ichi Hayashi amoto, Takaaki Kameji, Shintaro Iwashita, Kazuei Igarashi,

Characterization of a second hamster lung fibroblast mutant with defects in phosphatidylinositol-specific phospholipase C. Mike A. Leonis and David F. Silbert

A variant of exotoxin A that forms potent and specific chemically conjugated immunotoxins. G. Jilani Chaudry, R. Jerrold Fulton, and Rockford K. Draper

Phosphoinositide 3-kinase is activated by phosphopep- tides that bind to the SH2 domains of the 85-kDa sub- unit. Christopher L. Carpenter, Kurt R. Auger, Manas Chan-

son, and Lewis C. Cantley udhuri, Monique Yoakim, Brian Schaffhausen, Steven Shoel-

Expression of dopamine &hydroxylase in Drosophila Schneider 2 cells. Evidence for a mechanism of mem- brane binding other than uncleaved signal peptide. Karen R. Gibson, Philip G. Vanek, William D. Kaloss, G. Bruce Collier, John F. Connaughton, Monica Angelichio, George P. Liui, and Patrick J . Fleming

Effects of truncation of human Pro-tumor necrosis fac-

shihiko Utsumi, Alla Leuitan, Mien-Chie Hung, and J i m tor transmembrane domain on cellular targeting. To-

Klostergaard

Two isoforms of prostaglandin E receptor EPI subtype. Different COOH-terminal domains determine sensitiv- ity to agonist-induced desensitization. Manabu Negishi,, Yukihiko Sugimoto, Atsushi Irie, Shuh Narumzya, and Atsushz Ichikawa

cyte chemoattractant J E via fos andjun genes in clonal Tumor necrosis factor-a induces expression of mono-

osteoblastic MC3T3-El cells. Shigemnsa Hanazawa, Akira

azuka, Hideo Katoh, and Shigeo Kztano Takeshita, Shigeru Amano, Toshihiko Semba, Tadanobu Nir-

Tyrphostin inhibits bombesin stimulation of tyrosine phosphorylation, c-fos expression, and DNA synthesis in Swiss 3T3 cells. Michael Seck1 and Enrique Rozengurt

Activation of ADP-ribosylation factor by Golgi mem- branes. Evidence for a brefeldin A- and protease-sen- sitive activating factor on Golgi membranes., Paul A . Randazzo, Yun Chung Yang, Cherrie Rulka, and Rzchard A. Kahn

9564 Direct evidence for tyrosine and threonine phosphoryl- ation and activation of mitogen-activated protein ki- nase by vasopressin in cultured rat vascular smooth muscle cells. Yosef Granot, Eleanor Erikson, Hagit Fridman, Vicki Van Putten, Bryan Wdzams, Robert W. Schner, and James L. Maller

9585 Interaction with newly synthesized and retained pro- teins in the endoplasmic reticulum suggests a chaperone function for human integral membrane protein IP90 (calnexin). Vudaine David, Frans Hochstenbach, Sumati Ra- jagopalan, and Michael B. Brenner

9593 Induction of peroxisomal fatty acid @-oxidation and liver fatty acid-binding protein by peroxisome prolif- erators. Mediation via the cytochrome P-450IVA1 w - hydroxylase pathway. Raja M. Kaikaus, William K. Chan, Nina Lysenko, Rupsa Ray, Paul R. Ortiz de Montellano, and Nathan M. Bass

9611 Long term growth factor exposure and differential ty- rosine phosphorylation are required for DNA synthesis in BALB/c 3T3 cells. Xi Zhan, Xiaoguo Hu, Robert Friesel, " "_ " - . . "_. -. I ~ . ~ ~~~~

pp60"'". Michael S. Simonson and Wikarn H. Hirman and Thomas Maciag

Indicates a Communication

viii

ix

9621

9645

9653

9730

9747

9753

9762

9780

9803

9817

9847

9856

9863

9892

9901

9908

09161

Identification of a soluble receptor for platelet-derived growth factor in cell-conditioned medium and human plasma. Jay Tiesman and Charles E. Hart

Expression and role of c-myc in chondrocytes undergo- ing endochondral ossification. Masahiro Iwamoto, Kimi- toshi Yagami, Phyllis Lu Valle, Bjorn R. Olsen, Christos J . Petropoulos, Donuld L. Ewert, and Maurizio Pacifici

Lysosomal accumulation of unesterified cholesterol in model macrophage foam cells. Rajendra K. Tangirala, Flor- ence H. Mahlberg, Jane M. Glick, W. Gray Jerome, and George H. Rothblat

Identification of a promoter element which participates in CAMP-stimulated expression of human insulin-like

Laura A. DePaolis, Phillip D. K. Lee, and David R. Powell growth factor-binding protein-1. Adisak Suwanichkul,

sible mechanism of insulin-induced RNA efflux from Insulin induces the phosphorylation of nucleolin. A pos-

Mark 0. J . Olson, and C. Ronald Kahn nuclei. Peter Csermely, T a m Schnuider, Bentley Cheatham,

sue distribution, and regulation of expression. Identi- Molecular analysis of human 8-arrestin-1: cloning, tis-

fication of two isoforms generated by alternative splic- ing. Giustino Parruti, Francesca Peracchia, Michele Sallese, Grazia Ambrosini, Mariateresa Masini, Domenico Rotilio, and Antonio De Blnsi

A transgenic mouse model for studying the lineage relationships and differentiation program of type I1 pneumocytes at various stages of lung development. J . Randall Hansbrough, Steven M. Fine, and Jeffrey I. Gordon

Kinetics of thrombin receptor cleavage on intact cells. Relation to signaling. Kenji Ishii, Lutz Hein, Brian Kobilka, and S h u n R. Coughlin

Co-regulation of the mitogen-activated protein kinase, extracellular signal-regulated kinase 1, and the 90- kDa ribosomal 56 kinase in PC12 cells. Distinct effects of the neurotrophic factor, nerve growth factor, and

Nguyen, Jean-Claude Scimeca, Chantal Filloux, Pascal Peraldi, the mitogenic factor, epidermal growth factor. Tien T.

Jean-Louis Carpentier, and Emmanuel Van Obberghen

Rapid agonist-mediated phosphorylation of m3-mus- carinic receptors revealed by immunoprecipitation. An- drew B. Tobin and Stefan R. Nahorski

Microtubule-associated protein 2 alters the dynamic properties of microtubule assembly and disassembly. Richard J . Kowalski and Robley C. Williams, Jr.

patients. Lesley A. Beavan, Edelgard Quentin-Hoffmann, Elke Deficient expression of decorin in infantile progeroid

Kresse Schonherr, Friedemann Snigula, Jules G. Leroy, and Hans

A high affinity conformational state on VLA integrin heterodimers induced by an anti-& chain monoclonal antibody. Alicia G. Arroyo, Angeles Garcia-Pardo, and Fran- cisco Sanchez-Madrid

The specific association of a phosphofructokinase iso- form with myocardial calcium-independent phospholi- pase Az. Implications for the coordinated regulation of phospholipolysis and glycolysis. Stanley L. Hazen and Richard W. Gross

Interactions between the bone matrix proteins osteo- pontin and bone sialoprotein and the osteoclast integrin u,Bs potentiate bone resorption. F. Patrick Ross, Jean chappel, Jose I. Alvarez, Diane Sander, William T. Butler, Mary C. Farach-Carson, Keith A. Mintz, Pamela Gehron Robey, Steven L. Teitelbaum, and David A. Cheresh

Mutational analysis of the Golgi retention signal of bovine B-1,4-galactosyltransferase. Arni S. Masibay, Pe- tety v. Balaji, Elizabeth E. Boeggeman, and Pradman K. Qasba

ENZYMOLOGY The substance P receptor, which couples to Gull, is a substrate of &adrenergic receptor kinase 1 and 2. Madan M. Kwatra, Debra A. Schwinn, Jolanda Schreurs, Jonuthan L. Blank, Chong M. Kim, Jeffrey L. Benouic, James E. Krause, Marc G. Caron, and Robert J . Lefkowitz

'9191

-9194

9238

9323

9337

9410

9425

9430

9466

9484

9496

9667

9675

981 1

9886

09184

9267

9343

Presteady state kinetics of an S-adenosylmethionine- dependent enzyme. Evidence for a unique binding ori- entation requirement for EcoRI DNA methyltransfer- ase. Norbert 0. Reich and Neda Mashhoon

Selective inhibition of protein kinase C isozymes by the indolocarbazole GO 6976. Georg Martiny-Baron, Marcelo

Koch, Hubert Hug, Dieter Marme, and Christoph Schachtele G. Kazanietz, Harald Mischak, Peter M. Blumberg, Georg

Escherichia coli thioesterase I, molecular cloning and sequencing of the structural gene and identification as a periplasmic enzyme. Hyeseon Cho and John E. Cronan, Jr.

The interaction of illimaquinone, a selective inhibitor of the RNase H activity, with the reverse transcriptases of human immunodeficiency and murine leukemia retroviruses. Shoshana Loya and Amnon Hizi

Kinetic characterization of a &glucosidase from a yeast, Candida wickerhamii. Shelby N. Freer

Mutants of Rab3A analogous to oncogenic Ras mutants. Sensitivity to Rab3A-GTPase activating protein and

Brondyk, Colleen J . McKiernan, Ethan S. Burstein, and Ian Rab3A-guanine nucleotide releasing factor. William H.

G. Macara

Calmodulin-dependent nitric-oxide synthase. Mecha-

Donald J. Wolff, George A. Datto, Raymond A. Samatouicz, and nism of inhibition by imidazole and phenylimidazoles.

Richard A. Tempsick

nitric-oxide synthase by antifungal imidazole agents. The dual mode of inhibition of calmodulin-dependent

Donald J. Wolff, George A. Datto, and Raymond A. Samotouicz

Isolation of a human liver fructose-l,6-bisphosphatase cDNA and expression of the protein in Escherichia coli. Role of Asp-118 and Asp-121 in catalysis. M. Raafat El-Maghrabi, Madhaui Gidh-Jain, LeeAnn R. Austin, and Si- mon J . Pilkis

Purification and properties of 2'-hydroxybenzalpyru- vate aldolase from a bacterium that degrades naphtha- lenesulfonates. Andrea E. Kuhm, Hans-Joachim Knnck- muss, and Andreas Stolz

Differences in the properties and enzymatic specifici- ties of the two active sites of angiotensin I-converting enzyme (kininase 11). Studies with bradykinin and other natural peptides. Emmanuel Jaspard, L e i Wei, and Francois Alhenc-Gelas

Regulation of purified subtypes of phosphatidylinosi- tol-specific phospholipase C B by G protein a and By subunits. Alan V. Smrcka and Paul C. Sternwels

High level expression of mammalian protein farnesyl- transferase in a baculovirus system. The purified pro- tein contains zinc. Wen-Ji Chen, John F. Moomaw, Laurie Ouerton, Thomas A. Kost, and Patrick J. Casey

Interaction between staphylokinase, plasmin(ogen), and az-antiplasmin. Recycling of staphylokinase after neutralization of the plasmin-staphylokinase complex by az-antiplasmin. Karen Silence, Desire Collen, and H. Roger Lijnen

Enzymatic characterization of @-D-galactoside a2,3- trans-sialidase from Trypanosoma cruxi. Peter Scudder, James P. Doom, Marina Chuenkova, Ian D. Manger, and Miercio E. A. Pereira

MEMBRANES AND BIOENERGETICS

with and is phosphorylated by the SO-kDa polypeptide The coated vesicle vacuolar (H+)-ATPase associates

of the clathrin assembly protein AP-2. Melanie Myers and Michael Forgac

Role of the fusion peptide sequence in initial stages of influenza hemagglutinin-induced cell fusion. Christian Schoch and Robert Blumenthal

Phosphate affects the distribution of flux control among the enzymes of oxidative phosphorylation in rat skeletal muscle mitochondria. Elke Wisniewski, Wolfram S. Kunz, and Frank Norbert Gellerich

Indicates a Communication

X

9442 Charged residues render pro-OmpA potential depend- ent for initiation of membrane translocation. Bruce Geller, Heng- Yi Zhu, Shiyuan Cheng, Andreas Kuhn, and Ross E. Dalbey

9473 The MglA component of the binding protein-dependent galactose transport system of Salmonella typhimurium

delhamid El Yaagoubi, and Masamichi Kohiyama is a galactose-stimulated ATPase. Gilbert Richarme, Ab-

9824 Evidence for involvement of the voltage-dependent Na+ channel gating in depolarization-induced activation of G-proteins. Malca Cohen-Armon and Mordechai Sokolousky

NUCLEIC ACIDS, PROTEIN SYNTHESIS, AND MOLECULAR GENETICS

*9172 The Wilms’ tumor gene product WT1 activates or sup- presses transcription through separate functional do- mains. Zhao- Y i Wang, Qing-Qing Qiu, and Thomas F. Deuel

9206 Molecular cloning and analysis of the NAG1 cDNA coding for glucosamine-6-phosphate deaminase from Candida albicans. Krishnamurthy Natarajan and Asis Datta

9275 Molecular characterization of the gene encoding the y subunit of the human skeletal muscle l,4-dihydropyri- dine-sensitive Caa+ channel (CACNLG), cDNA se- quence, gene structure, and chromosomal location. Pa- tricia A. Powers, Shuying Liu, Kirk Hogan, and Ronald G. Gregg

9296 Two different, overlapping pathways of transcription initiation are active on the TATA-less human androgen receptor promoter. The role of Spl . Peter W. Faber, Henrz

Jan Trapman C. J. uan Rooij, Helma J. Schipper, Albert 0. Brinkmnnn, and

9316 Identity elements of tRNATw. Identification and evo- lutionary conservation. Hong Xue, Wenyan Shen, Richard Giege, and J . Tze-Fei Wong

9329 Analysis of gas vesicle gene expression in HaZoferax mediterranei reveals that GvpA and GvpC are both gas

Pfeifer vesicle structural proteins. Christoph Englert and Felicitas

9358 Temperature-sensitive mutations in the phage P22 coat protein which interfere with polypeptide chain folding. Carl L. Gordon and Jonathan King

9376 A novel form of cytochrome P-450 family 4 in human polymorphonuclear leukocytes. cDNA cloning and expression of leukotriene B4 w-hydroxylase. Yasushi

Kazuhiro Sogawa, Yoshiaki Fujii-Kuriyama, and Masamichi Kikuta, Emi Kusunose, Katsuya Endo, Satoru Yamamoto,

Kusunose

9387 Identification of a novel serum and growth factor-in- ducible gene in vascular smooth muscle cells. Ping Feng and Gene Liau

9448 Organization and nucleotide sequence of the Bacillus subtilia diaminopimelate operon, a cluster of genes en- coding the first three enzymes of diaminopimelate syn- thesis and dipicolinate synthase. Nut- Yong Chen, Shu-Qtn Jiang, Donald A. Klein, and Henry Paulus

9504 The 5’ and 3‘ untranslated regions of satellite tobacco necrosis virus RNA affect translational efficiency and

Lisa A. Benkowskl, Davd Schodin, Sandra R., Lax , Anneke M. dependence on a 5’ cap structure. Rtchard T. Ttmmer,

Metz, Joanne M. Ravel, and Karen S. Brownzng

9522 High-level and erythroid-specific expression of human glucose-6-phosphate dehydrogenase In transgenic mice. Tang K. Tang, Ka-Bik Tam, and See-Chang H u n g

9533 Complex patterns of sequence variation and multiple 6‘ and 3’ ends are found among transcripts of the erythroid ankyrin gene. Connte S. Birkenmeier, Robert A.

Jane E. Barker White, Luanne L. Peters, Elaine J. Hall, Samuel E. Lux, and

9578 Purification and characterization of DNA helicase 111

and Akio Sugino from the yeast Saccharomyces cereuisiae. Kikuo Shimizu

9629 Wild type GAL4 binds cooperatively to the GALI-10 UASc in vitro. Tim Kang, T im Martins, and Iuan Sadowski

9661

9690

9725

9731

9793

9839

9869

9879

9917

9936

-9180

9223

9230

9246

9311

9381

9400

9541

Macrosialin, a mouse macrophage-restricted glycopro- tein, is a member of the lampflgp family. Claire L. Hol- ness, Rosangela P. da Silua, Jonathan Fawcett, Siamon Gordon, and Dauid L. Simmons

Eukaryotic topoisomerase I-mediated cleavage re- quires bipartite DNA interaction. Cleavage of DNA substrates containing strand interruptions implicates a role for topoisomerase I in illegitimate recombination. Kent Christiansen, A. Barbara Dirac Suejstrup, Anni H. An- dersen, and Ole Westergaard

Site-directed mutagenesis of the arginine-glycine-as- partic acid in vitronectin abolishes cell adhesion. Rich- ard C. Cherny, Marilyn A. Honan, and Perumal ThtagaraJan

The glutathione S-transferase D genes. A divergently organized, intronless gene family in Drosophila mela- nogaster. Yann-Pyng S. Toung, Tao-shih Hsieh, and Chen-Pei D. Tu

Template-directed pausing of DNA synthesis by HIV- 1

sequences in vitro. George J. K h r m n n , Cherylene A. reverse transcriptase during polymerization of HIV- 1

Schuuber, and Bradley D. Preston

Hormonal/metabolic regulation of the human GLUT4/ muscle-fat facilitative glucose transporter gene in transgenic mice. Ann Louise Olson, Min-Ling Liu, W. Scott Moye-Rowley, John B. Buse, Graeme I. Bell, and Jeffrey E. Pessin

CAMP-dependent protein kinase represses myogenic differentiation and the activity of the muscle-specific helix-loop-helix transcription factors Myf-6 and

A rmld MyoD. Barbara Winter, Thomas Braun, and Hans Henning

Neural expression of a novel alternatively spliced and

J. Mutchler, Brian E. Sullivan, Thomas M. Lanigan, Michael polyadenylated Gsa transcript. J. Adam Crawford, Kendra

S. Clark, and Andrew F. Russo

Analysis of the tissue-specific promoter of the MUCl gene. Ales Kouarik, Nigel Peat, Dauid Wilson, Sandra J . Gendler, and Joyce Taylor-Papadimitriou

Hexokinase I1 mRNA and gene structure, regulation by insulin, and evolution. Vol. 268 (1993) 5209-5219. Richard L. Printz, Stephen Koch, Lincoln R. Potter, Robert M. O’Doherty, James J. Tiesinga, Syluiane Moritz, and Daryl K. Granner

PROTEIN CHEMISTRY AND STRUCTURE A keratinocyte growth factor receptor-derived peptide antagonist identifies part of the ligand binding site. Donald P. Bottaro, Emma Fortney, Jeffrey S. Rubin, and Stuart A. Aaronson

Effect of low molecular weight aliphatic alcohols and related compounds on platelet factor 4 subunit associ- ation. Yingqing Yang, Sharon Barker, Mu Jung Chen, and Kevin H. Mayo

Isolation and primary structure of the three major forms of granulin-like peptides from hematopoietic tis- sues of a teleost fish (Cyprinus carpio). Daniel R. Bel- court, Claude Lazure, and Hugh P. J. Bennett

Binding of mutants of human insulin-like growth factor 11 to insulin-like growth factor binding proteins 1-6. Leon A. Bach, Susan Hsieh, Katsu-ichi Sakano, Hiroyuki Fu- jiwara, James F. Perdue, and Matthew M. Rechler

Amino/carboxyl-terminal deletion mutants of human choriogonadotropin 8. Jianing Huang, Fang Chen, and Dauid Puett

Isolation and characterization of the chains of type V/ type XI collagen present in bovine vitreous. Richard Mayne, Randolph G. Brewton, Pauline M. Mayne, and John R. Baker

Characterization of mutant rhodopsins responsible for autosomal dominant retinitis pigmentosa. Mutations on the cytoplasmic surface affect transducin activation. K. Christopher Min, Tatyana A. Zuyaga, Aaron M. Cypess, and Thomas P. Sakmar

Identification and purification of a novel serine pro- teinase inhibitor. Paul B. Coughlin, Tim Tetaz, and Hatem H . Salem

Indicates a Communication

xi

9604 The calmodulin-binding domain of the mouse 90-kDa heat shock protein. Yasufumi Minami, Hiroshi Kawasaki, Koichi Suzuki, and Ichiro Yahara

9636 Locations and immunoreactivities of phosphorylation sites on bovine and porcine tau proteins and a PHF-tau fragment. Linda Poulter, Derek Barratt, Clay W Scott, and Claudia B. Caputo

9681 Cloning, sequencing, distribution, and expression in Escherichia coli of flavin-containing monooxygenase

Emmanuel Atta-Asafo-Adjei, Michael P. Lawton, and Richard 1C1. Evidence for a third gene subfamily in rabbits.

M. Philpot

9702 Multiple endoglycosidase F activities expressed by Fla- vobacterium meningosepticurn endoglycosidases Fz and Fs. Molecular cloning, primary sequence, and en- zyme expression. Anthony L. Tarentino, Geraldine Qui- nones, Li-Ming Changchien, and Thomas H. Plummer, Jr.

9709 Use of endoproteases to identify catalytic domains, linker regions, and functional interactions in soluble peptidylglycine a-amidating monooxygenase. E. Jean Hwten, Francisco A. Tausk, Henry T. Keutmann, and Betty A. Eipper

9771 Mapping of neutralizin epitopes and the receptor bind- ing site of human interfeukin 18. Philip L. Simon, Vasant Kumar, Jay S. Lillquist, Pradip Bhatnagar, Richard Einstein, John Lee, Terence Porter, Dauid Green, Ganesh Sathe, and Peter R. Young

9787 The three-dimensional structure of the ligand-binding domain of a wild-type bacterial chemotaxis receptor. Structural comparison to the cross-linked mutant forms and conformational changes upon ligand binding. Joanne I. Yeh, Hans-Peter Biemann, Jayuardhan Pandzt, Daniel E. Koshland, and Sung-Hou Kim

9936 Evidence that both Cas*-specific sites of skeletal muscle TnC are required for full activit . Vol. 266 (1990) 21554,21560. Zelin Sheng, Wdham 1. Straws, Jean-Marie Francols, and James D. Potter

Aaronson, Stuart A,, 9180,

Alhenc-Gelas, Francois, 9496 Alvarez, Jose I., 9901 Amano, Shigeru, 9526

Andersen, Anni H., 9690 Ambrosini, Grazia, 9753

Angelichio, Monica, 9490 Arnold, Hans Henning, 9869 Arroyo, Alicia G., 9863 Atta-Asafo-Adjei, Emmanuel,

Auffredou, Marie Therese,

Auger, Kurt R., 9478 Austin, LeeAnn R., 9466

Bach, Leon A,, 9246 Baker, John R., 9381 Balaji, Petety V., 9908 Barker, Jane E., 9533 Barker, Sharon, 9223 Barratt, Derek, 9636 Bass, Nathan M., 9593 Bassler, Bonnie L., 9405 Beavan, Lesley A,, 9856

Belcourt, Daniel R., 9230 Beeler, John F., 9287

Bell, Graeme I., 9839 Benkowski, Lisa A., 9504 Bennett, Hugh P. J., 9230 Benovic, Jeffrey L., 9161 Bertoglio, Jacques, 9169 Bhatnagar, Pradip, 9771 Bielawska, Alicja, 9255 Biemann, Hans-Peter, 9787 Birkenmeier, Connie S., 9533 Blank, Jonathan L., 9161 Blumberg, Peter M., 9194 Blumenthal, Robert, 9267 Boeggeman, Elizabeth E.,

Bottaro, Donald P., 9180 Braun, Thomas, 9869 Brenner, Michael B., 9585 Brewton, Randolph G., 9381

Brondyk, William H., 9410 Brinkmann, Albert 0.. 9296

Browning, Karen S., 9504 Burstein, Ethan S., 9410 Buse, John B., 9839

Buxton, Joanne M., 9187 Butler, William T., 9901

Cantley, Lewis C., 9478

Caron, Marc G., 9161 Caputo, Claudia B., 9636

Carpenter, Christopher L.,

Carpentier, Jean-Louis, 9803

9287

9681

9169

9908

9478

Casey, Patrick J., 9675 Chan, William K., 9593 Changchien, Li-Ming, 9702 Chanudhuri, Manas, 9478 Chappel, Jean, 9901

Cheatham, Bentley, 9747 Chaudry, G. Jilani, 9437

Chen, Fang, 9311 Chen, Mu Jung, 9223 Chen, Nai-Yong, 9448 Chen, Wen-Ji, 9675

Cheresh, David A,, 9901 Cheng, Shiyuan, 9442

Cherny, Richard C., 9725 Cho, Hyeseon, 9238

Chuenkova, Marina, 9886 Christiansen, Kent, 9690

Clark, Michael S., 9879 Cohen-Armon, Malca, 9824 Collen, DBsiri, 9811 Collier, G. Bruce, 9490 Comoglio, Paolo M., 9165 Connaughton, John F., 9490 Coughlin, Paul B., 9541 Coughlin, Shaun R., 9780

Cronan, John E., Jr., 9238 Crawford, J. Adam, 9879

Cross, George A. M., 9570 Csermely, Peter, 9747 Cypess, Aaron M., 9400 Czech, Michael P., 9187 Dalbey, Ross E., 9442 dalla Zonca, Paolo, 9165

Datta, Asis, 9206 da Silva, Rosangela P., 9661

Datto, George A., 9425, 9430 David, Violaine, 9585 De Blasi, Antonio, 9753 Decker, Stuart J., 9176

Deuel, Thomas F., 9172 DePaolis, Laura A., 9730

Dohrowsky, Rick T., 9255 Doering, Tamara L., 9215 Doom, James P., 9886 Dorseuil, Olivier, 9169 Draper, Rockford K., 9437 Einstein, Richard, 9771 Eipper, Betty A,, 9709 El-Maghrabi, M. Raafat,

9466 EIYaagoubi, Abdelhamid,

9473 Endo, Katsuya, 9376 Englert, Christoph, 9329 Englund, Paul T., 9215 Erikson, Eleanor, 9564 Ewert, Donald L., 9645

AUTHOR INDEX

Faber, Peter W., 9296 Farach-Carson, Mary C.,

Fawcett, Jonathan, 9661 Feng, Ping, 9387 Field, Mark C., 9570 Filloux, Chantal, 9803 Fine, Steven M., 9762 Fishbein, Julie D., 9255 Fleming, Patrick J., 9490 Forgac, Michael, 9184

Francois, Jean-Marie, 9936 Fortney, Emma, 9180

Frants, Rune R., 9369 Freer, Shelby N., 9337

Friesel, Robert, 9611 Fridman, Hagit, 9564

Fujii-Kuriyama, Yoshiaki,

Fujiwara, Hiroyuki, 9246 Fulton, R. Jerrold, 9437

Gacon, Gerard, 9169 Garcia-Pardo, Angeles, 9863 Garrett, Stephen, 9255 Geller, Bruce, 9442 Gellerich, Frank Norbert,

Gendler, Sandra J., 9917 Gibson, Karen R., 9490 Gidh-Jain, Madhavi, 9466 Giege, Richard, 9316 Glick, Jane M., 9653 Gordon, Carl L., 9358 Gordon, Jeffrey I., 9762 Gordon, Siamon, 9661 Gramaglia, Daniela, 9165 Granner, Daryl K., 9936 Granot, Yosef, 9564 Gravel, Sylvie, 9280 Graziani, Andrea, 9165 Green, David, 9771 Gregg, Ronald G., 9275 Gross, Richard W., 9892 Hall, Elaine J., 9533 Hanazawa, Shigemasa, 9526 Hannun, Yusuf A., 9255 Hansbrough, J. Randall, 9762 Hart, Charles E., 9621 Hart, Gerald W., 9215

Havekes, Louis M., 9369 Hashefi, Mandana, 9280

Hayashi, Shin-ichi, 9393 Hazen, Stanley L., 9892 Heidaran, Mohammad A,,

9901

9376

9343

93A7 HGiY Lutz, 9780 Herman, William H., 9347 Hiraizumi, Sen, 9927

Hizi, Amnon, 9323 Hochstenbach, Frans, 9585 Hoff, Eleanor F., 9215 Hogan, Kirk, 9275 Holness, Claire L., 9661

Horwitz, Kathryn B., 9262 Honan, Marilyn A,, 9725

Hsieh, Susan, 9246 Hsieh, Tao-shih, 9737 Hu, Xiaoguo, 9611 Huang, Jianing, 9311 Huang, Kristen M., 9302 Huang, See-Chang, 9522 Hug, Hubert, 9194 Hung, Mien-Chie, 9511 Husten, E. Jean, 9709

Ichikawa, Atsushi, 9517 Igarashi, Kazuei, 9393 Irie, Atsushi, 9517 Ishibashi, Toshio, 9287 lshii, Kenji, 9780 lwamoto, Masahiro, 9645 Iwashita, Shintaro, 9393

Jansen, Hans, 9369 Jaspard, Emmanuel, 9496 Jerome, W. Gray, 9653 Jiang, Shu-Bin, 9448

Kahn, C. Ronald, 9747 Kahn, Richard A,, 9555 Kaikaus, Raja M., 9593 Kaloss, William D., 9490 Kameji, Takaaki, 9393 Kanamoto, Ryuhei, 9393 Kang, Tim, 9629 Katoh, Hideo, 9526 Kawasaki, Hiroshi, 9604 Kazanietz, Marcelo G., 9194 Keutmann, Henry T., 9709 Kikuta, Yasushi, 9376 Kim, Chong M., 9161 Kim, Sung-Hou, 9787 King, Jonathan, 9358 Kitano, Shigeo, 9526

Klein, Donald A., 9448 Klarmann, George J., 9793

Klostergaard, Jim, 9511 Knackmuss, Hans-Joachim,

Koch, Stephen, 9936 Kohilka, Brian, 9780

Kochs, Georg, 9194 Kohiyama, Masamichi, 9473 Koshland, Daniel E., 9787 Kost, Thomas A,, 9675 Kovarik, Ales, 9917 Kowalski, Richard J., 9847 Krause, James E., 9161

9484

Kresse, Hans, 9856 Kuhm, Andrea E., 9484 Kuhn, Andreas, 9442 Kumar, Vasant, 9771 Kunz, Wolfram S., 9313

Kusunose, Masamichi, 9376 Kusunose, Emi, 9376

Kwatra, Madan M., 9161

Lanigan, Thomas M., 9879 LaRochelle, William J., 9287 Lawton, Michael P., 9681 Lax, Sandra R., 9504 Lazure, Claude, 9230 Lee, John, 9771 Lee, Phillip D. K., 9730 Lefkowitz, Robert J., 9161 bonis , Mike A., 9416 Leroy, Jules G., 9856 Levitan, Alla, 9511 Liau, Gene, 9387 Lijnen, H. Roger, 9811 Lillquist, Jay S., 9771 Liu, Min-Ling, 9839 Liu, Shuying, 9275 Livi, George P., 9490

Loya, Shoshana, 9323 Lombardi, Paola, 9369

Lux, Samuel E., 9533 Lysenko, Nina, 9593

Maciag, Thomas, 9611 Macara, Ian G., 9410

MacLeod, R. John, 9280 Mahlberg, Florence H., 9653

Manger, Ian D., 9886 Maller, James L., 9564

Marme, Dieter, 9194 Martins, Tim, 9629 Martiny-Baron, Georg, 9194 Mashhoon, Neda, 9191

Masini, Mariateresa, 9753 Masihay, Arni S., 9908

Mayne, Pauline M., 9381 Mayne, Richard, 9381 Mayo, Kevin H., 9223 McCormick, Frank, 9157 McKiernan, Colleen J., 9410 Medina-Acosta, Enrique,

Metz, Anneke M., 9504

Min, K. Christopher, 9400 Mills, Elaine, 9280

Minami, Yasufumi, 9604 Mintz, Keith A,, 9901 Mischak, Harald, 9194 Moomaw, John F., 9675

Moye-Rowley, W. Scott, 9839 Moritz, Sylviane, 9936

Mulder, Monique, 9369

9570