october 2017 nucleus 9-14-17aa6web · jamie mccabe dunn,merck & co. steven mennen, amgen inc....
TRANSCRIPT
http://www.nesacs.org
October 2017 Vol. XCVI, No.2
NORTHEASTERN SECTION • AMERICAN CHEMIC
ALSO
CIET
Y
FOUNDED 1898
NESACS
Monthly Meetingat Waters Corporation, Milford, MARecognition of 50- and 60-Year Members
Marietta Haeg Schwartz1961–2017
21st Andrew H. WeinbergSymposiumJames E. Bradner, M.D., to speak at Dana-FarberCancer Institute
2017 NESACS/GDChExchange Trip to MainzBy Thomas Gilbert
2 The Nucleus October 2017
SAVE THE DATENortheastern Section of the American Chemical SocietyProcess Chemistry Symposium
Date Thursday, October 12, 2017Location Merck Boston Auditorium
33 Avenue Louis Pasteur Boston, MA 02115
Confirmed Stephen Buchwald, Massachusetts Institute of TechnologySpeakers Timothy Curran, Vertex Pharmaceuticals Inc.
Jamie McCabe Dunn,Merck & Co. Steven Mennen, Amgen Inc. Sarah Reisman, California Institute of Technology
Richmond Sarpong, University of California, Berkeley Corinna Schindler, University of Michigan Jim Yang, Biogen
• Save the date – October 12, 2017 - for a day-long symposium focused onprocess chemistry and featuring speakers from industry and academia.There will be opportunities to network with members of the local chemistrycommunity during lunch and a late afternoon reception.
• Seating is limited, and registrations will be honored on a first come, firstserved basis. Register at:
• http://www.acssymposium.com/NESACS/registration.html• Questions? Please contact a member of the symposium organizing com-mittee.
• Katherine Lee [email protected]• Matthew Maddess [email protected]• Steven Mennen [email protected]• Erin O’Brien [email protected]• Scott Plummer [email protected]• Stefanie Roeper [email protected]
Northeastern Section of the American Chemical SocietyWWW.NESACS.org
The Nucleus October 2017 3
The Nucleus is published monthly, except June and August, by the Northeastern Section of the AmericanChemical Society, Inc. Forms close for advertising on the 1st of the month of the preceding issue. Textmust be received by the editor six weeks before the date of issue.Editor: Michael P. Filosa, Ph.D., 18 Tamarack Road, Medfield, MA 02052 Email:
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The Northeastern Section of the American-Chemical Society, Inc.Office: Anna Singer, 12 Corcoran Road,Burlington, MA 01803(Voice or FAX) (781)272-1966.e-mail: [email protected] Homepage:http://www.NESACS.orgOfficers 2017ChairLeland L. Johnson, Jr.WuXi AppTecBrookline, MA(617)[email protected] Levine35 Cottage StSharon, MA 02067-2130(516)[email protected] Past ChairJerry P. JasinskiKeene State CollegeKeene, NH [email protected] SingerMilliporeSigma3 Strathmore Rd, Natick, MA 01760(774)290-1391, [email protected] Saha67 Bow StArlington, MA 02474-2744(978)[email protected] GordonArchivistKen MattesTrusteesRuth Tanner, Peter C. Meltzer, Dorothy PhillipsDirectors-at-LargeRalph Scannell, John Burke, David Harris,Ioannis Papayannopoulos, Michael P. Filosa,John NeumeyerCouncilors/Alternate CouncilorsTerm Ends 12/31/2017Michael P. Filosa John PodobinskiDoris I. Lewis Sonja Strah-PleynetPatricia A. Mabrouk Anna Waclawa SromekMark Tebbe Mary BurgessMorton Z. Hoffman Ralph ScannellTerm Ends 12/31/2018Katherine Lee Mukund S. ChorghadeCatherine E. Costello Andrew ScholteRuth Tanner R. Christian MoretonJackie O’Neil Ajay PurohitKenneth Mattes Robert LichterTerm Ends 12/31/2019Thomas R. Gilbert Leland L. Johnson, Jr.Mary Jane Shultz Mary A. MahaneyMichael Singer Jerry P. JasinskiLisa Marcaurelle Sofia SantosMarietta Schwartz Patrick M. Gordon
ContentsNESACS Process Chemistry Symposium_____________________2 Thursday, October 12, 2017, at Merck-BostonLecture by Jean-Marie Lehn at Northeastern University_________4 Nobel Laureate speaks about “adaptive chemistry”Monthly Meeting _______________________________________5 Recognition of 50- and 60-year Members at Waters Corporation, Milford, MA. Announcements ________________________________________6 ACS National Election, Call for Nominations-Gustavus John Esselen Award for Chemistry in the Public Interest,Grants-in-Aid to Undergraduates to attend the 255th ACS National Meeting21st Andrew H. Weinberg Symposium ______________________7 James E. Bradner, M.D., President, Novartis Institutes for Biochemical Research, to speak at Dana-Farber Cancer Institute2017 NESACS/GDCh Exchange Trip to Mainz, Germany_________8 By Thomas GilbertNational Chemistry Week Calendar of Events_________________9NESACS Wins Chemluminary Award _______________________122018 ACS National Awards to NESACS Members ____________122017 NESACS 50, 60 and 70-year Members _______________13Marietta Haeg Schwartz ________________________________13 1961–2017Chemist Answers 400-Year Old Question ___________________14Calendar ____________________________________________16Cover: James E. Bradner, M.D., Novartis Institutes for Biochemical Research, speaker at the 21st Annual Andrew H. Weinberg Symposium. Photo courtesy of Dr. Bradner.Editorial Deadlines: December 2017 Issue: October 22, 2017 January 2018
Issue: November 22, 2017
All Chairs of standingCommittees, the editor of THE NUCLEUS, and the Trustees of SectionFunds are members of theBoard of Directors. AnyCoun cilor of the American Chemical Societyresiding within the section area is an ex officiomember of the Board of Directors.
On Friday, May 12, 2017, ChemistryNobel Laureate, Professor Jean-MarieLehn of the University of Strasbourg(France) Institute for Advanced Study,spoke at a special seminar in the Collegeof Engineering at Northeastern Univer-sity. His talk, entitled “Perspectives inChemistry: From Supramolecular To-wards Adaptive Chemistry - Pure andApplied,” was followed by a luncheonreception that was co-sponsored by NE-SACS and the Northeastern UniversityCollege of Engineering.
Professor Lehn shared the 1987Nobel Prize in Chemistry with DonaldCram (UCLA) and Charles Pedersen(Du Pont) “for their development anduse of molecules with structure-specificinteractions of high selectivity,” whichis the chemical basis for “molecularrecognition” in biological processeswhereby a receptor molecule recognizesand selectively binds a substrate.
Over the years, Prof. Lehn’s workled to the new field of “supramolecularchemistry,” which deals with the com-plex entities formed by the associationof two or more chemical species held to-
gether by noncovalent intermolecularforces, in contrast to molecular chem-istry where the entities are constructedfrom atoms linked by covalent bonds.That area of research has developed intothe chemistry of “self-organization”processes, and more recently toward“adaptive chemistry,” dynamic net-works, and complex systems.
Prof. Lehn was born in 1939 inRosheim, France. He received his Ph.D.in 1963 from the University of Stras-bourg on the early use of proton NMRfor structure elucidation, and spent thefollowing year at Harvard University asa postdoctoral research associate in thelaboratory of R.B. Woodward, where heworked on the synthesis of Vitamin B12.He also had the opportunity to performquantum mechanical computations withRoald Hoffmann in what would be thedevelopment of the Woodward-Hoff-mann rules. He returned to a faculty po-sition at the University of Strasbourgand was promoted to Professor in 1970.He spent the spring semesters of 1972and 1974 as visiting professor at Har-vard University. In 1979, he was electedto the chair of Chimie des InteractionsMoléculaires at the Collège de France in
Paris. The author of more than 950 sci-entific publications, Lehn is a memberof many academies and institutions, andhas received numerous internationalhonors and awards.
Professor of Chemical EngineeringHicham Fenniri of Northeastern Univer-sity, who studied for his Ph.D. underLehn’s supervision in Strasbourg andwas instrumental in inviting him toBoston for his talk, stated, “This eventwas attended by researchers from mostacademic and industrial institutions inthe greater Boston area, whose feedbackhas been nothing but gratitude andamazement at the opportunity to hearfrom one of the most influential scien-tific minds of our time.” u
Lecture by Prof. Jean-Marie Lehn atNortheastern University
(l-r) Thomas Webster (Chair, Department ofChemical Engineering, NU); Nadine Aubry(Dean, College of Engineering, NU); Jean-Marie Lehn (University of Strasbourg); HichamFenniri (Professor, Department of Chemical En-gineering, NU); Mindy Levine (Professor, De-partment of Chemistry, University of RhodeIsland; NESACS Chair-Elect).
Photo by Francesca Fuerman
4 The Nucleus October 2017
NESACS Sponsors 2016Platinum $5000+Amgen Biogen Johnson Matthey Millipore-SigmaPCI Synthesis SK Life Science
Gold $3500 up to $5000Navin Fluorine
Silver $2000 up to $3500Abbvie American Chemical Society IAC Grant Boston Foundation Esselen Bristol-Myers Squibb Mettler Toledo Novartis Strem Chemicals Vertex Pharmaceuticals
Bronze $500 up to $2000Alexion AstraZeneca Chemical Computing Group Cydan Development DeuteRx LLC GL Chemtech International Limited JEOL USA Inc Organix, Inc. Pharmacore Relay Therapeutics Selvita, Inc. Toxikon
SeniorChemistsLuncheon
Monday, October 16, 20172:00 – 4:00 P.M.Panera Bread
1684 Massachusetts AvenueLexington, MA
(parking behind the building)Please join us for relaxed fellowshipand a chance to catch up with eachother and with ACS happenings.Friends and family welcome! u
The Nucleus October 2017 5
Monthly MeetingThe 972nd Meeting of the Northeastern Section of the American Chemical Society – Hosted by Waters CorporationPresentation of 50- and 60-year members. Thursday, October 5, 2017Waters Corporation34 Maple St., Milford, MA 01757Agenda:4:30 pm Board Meeting (Alliance Room)5:30 pm Social Hour (Atrium Rooms 1, 2, 3)6:15 pm Dinner (North Cafe)7:15 pm Welcome and Introduction7:30 pm Presentation of 50- and 60- year members7:50 pm Evening Program: Professor Katherine Mirica, Assistant Profes-
sor, Department of Chemistry, Dartmouth College “Stimuli-Responsive Materials for Chemical Sensing and Microelectronics”
To register use the following Eventbrite link: https://www.eventbrite.com/e/ne-sacs-october-meeting-at-waters-corporation-in-milton-ma-05-oct-2017-tickets-37157156054"For further information contact the Section Administrative Coordinator, AnnaSinger at <[email protected]>. Please note that the office is open on a Part-Time basis only.THE PUBLIC IS INVITED - RESERVATIONS ARE REQUIRED before Sep-tember 28, 2017.Registration is required and an ID will be required to enter the Waters facility.Parking is available on-site.Directions: http://www.waters.com/waters/en_US/Directions-To-Waters-US-/nav.htm?cid=10062899 u
Abstract: Stimuli-responsive materials hold prom-ise for enabling the fabrication ofportable chemical sensors and micro-electronic devices with the goal of im-proving human health, safety, efficiency,and quality of life. This presentation willdescribe the molecular design, synthe-sis, and characterization of stimuli-re-sponsive multifunctional materials. Thefirst part of the presentation will de-scribe several approaches for interfacingconductive metal-organic frameworks(MOFs) with electrodes to create devices
with promising utility in gas detectionand capture. I will present several ap-proaches for direct self-assembly of con-ductive two-dimensional (2D) MOFsinto portable device architecture, anddemonstrate the utility of this approachin the context of gas sensing. I will alsodescribe how the modular structure-property relationships within this classof 2D MOFs can be designed to achieveelectrochemically-driven capture and re-lease of gases directly at the solid-gasinterface. The second part of this pres-entation will introduce a novel approachto designing materials for temporary ad-hesion, which relies on the use of sub-
limable organic compounds, with prom-ising utility in the fabrication of micro-electronic devices. u
Biography:
Katherine Mirica was born and raised ineastern Ukraine, and moved with herfamily to the state of Rhode Island dur-ing her freshman year in high school.She attended Boston College, where shedeveloped a passion for MaterialsChemistry, working in the laboratory ofLawrence T. Scott. She graduated withhigh honors in 2004, and later that yearmoved across the river to pursue gradu-ate studies at Harvard University. In2011, Katherine earned her Ph.D. inChemistry from Harvard Universityunder the guidance of George M. White-sides. Her doctoral dissertation focusedon the development and characterizationof a simple and portable method thatused magnetic levitation for density-based chemical analysis. She also con-tributed to several other research effortsin the areas of paper-based diagnosticsand protein biophysics. Katherine thenjoined the laboratory of Timothy M.Swager at the Massachusetts Institute ofTechnology as an NIH postdoctoral fel-low to pursue the development ofportable electronic carbon-based chem-ical sensors for the detection of haz-ardous gases and vapors. At MIT, shedeveloped a solvent-free approach, op-erationally analogous to drawing withpencil on paper, for the fabrication ofsensitive and selective sensors from car-bon nanomaterials. Katherine began herindependent scientific career as an As-sistant Professor in the Department ofChemistry at Dartmouth College in July2015. u
6 The Nucleus October 2017
Call forNominationsThe Gustavus John EsselenAward for Chemistry in thePublic InterestThe Northeastern Section of the Ameri-can Chemical Society (NESACS) isinviting nominations for its prestigiousGustavus John Esselen Award forChemistry in the Public Interest. Thisaward is given annually to a chemicalscientist, whose scientific and technicalwork has contributed to the public well-being and has thereby communicatedthe positive values of the chemical pro-fession. The significance of this workshould have become apparent within thefive years preceding nomination. Theawardee shall be a living resident of theUnited States or Canada at the time ofthe nomination.
There is no limitation to the field ofchemistry. The selection committee fo-cuses on the general public recognitionof the work, as well as its scientific/tech-nical significance.
The Award consists of a bronzemedal and the sum of $5,000. Travel ex-penses incidental to the conferring of theaward will be reimbursed. The awardwill be presented at the April 2018 meet-ing of the Section. The Awardee is ex-pected to deliver an address on thesubject of the work for which the honoris conferred, or for work in progresswhich is also directed toward chemistryin the public interest.
Nominations should be submittedas a single pdf file including: 1) a lettersigned by the primary sponsor with a de-scription of the nominee’s work recog-nized as making a major contribution tothe public welfare and as communicatingpositive values of the chemical profes-sion, plus the names of two co-sponsors;2) short supporting co-sponsor state-ments; 3) the nominee’s professional bi-ography including a list of no more thanten of the nominee’s publications se-lected for their pertinence to the worknominated for recognition; and 4) copiesof popular and technical press news orfeature articles indicative of public ben-
efit and interest. Further information isavailable at www.nesacs.org.
Nominations Are Due October20, 2017 to [email protected] with cc [email protected]. Award recip-ients will be notified by February 1,2018.Inquiries may be directed to Dr. KarenAllen, Tel. (617) 358-5544 or JeanannePiper Grady, Tel. (617) 620-8315. Ad-dress: 11 Thaxter St., Hingham, MA02043. u
ACSNationalElectionBallots for the 2017 ACS fall nationalelection will be distributed on September29, with a voting deadline four weekslater, on October 27. In a change of pro-cedures, all members with an email ad-dress on file and eligible to vote will re-ceive an electronic ballot with the optionto request a paper ballot. Those mem-bers with no email address on file willbe sent a paper ballot with the option tostill vote electronically. The ACS elec-tion vendor, Survey & Ballot Systems,will send three email reminders duringthe voting period to those who have notvoted as of the reminder date. u
Grants-in-Aidto Under -grad uates to Attend the 255th ACSNational Meeting &Exposition, March 18-22, 2018,in New Orleans, LA The Northeastern Section of the Ameri-can Chemical Society (NESACS) willprovide Grants-in Aid of $350 to eachof four undergraduates to attend the255th ACS National Meeting in New Or-leans, LA, and to present a paper at theUndergraduate Research Poster Sessionin the Division of Chemical Education.The institutions of the successful appli-cants are expected to match the award. Eligibility: Applications will be ac-cepted from students at colleges anduniversities within the NortheasternSection of the ACS. The undergraduatestudent must be a chemistry, biochem-istry, chemical engineering, or molecu-lar biology major in good standing withat least junior status, and must be cur-rently engaged in undergraduate re-search.Application: Application forms may beobtained from the NESACS web site athttp://www.nesacs.org. The deadline forreceipt of completed applications byProfessor Matthew Gage, Chair of theGrants-in-Aid Committee, is October 2,2017. Completed applications are to besent to: Professor Matthew Gage, De-partment of Chemistry, University ofMassachusetts Lowell, 1 University Av-enue, Lowell, MA 01854 Phone:978/934-3683 Fax: 978/934-3013; e-mail: [email protected]: Applicants will be notifiedof the results by e-mail on October 9,2017. The deadline for electronic sub-mission of abstracts to the AmericanChemical Society in Washington, D.C.is October 23, 2017, 11:59 PM. u
JoinNESACS
on facebookwww.facebook.com/nesacs
The Nucleus October 2017 7
21st Annual Andrew H. WeinbergSymposiumJames E. Bradner, M.D.
President, Novartis Institutes for Biochemical Research“New Paths to the Waterfall: Rethinking the Science of Therapeutics
for Pediatric Malignancies”Wednesday, November 1, 2017
4:00 pm – 5:00 pmYawkey Conference Center, 3rd floor of the
Yawkey Center for Cancer Care at the Dana-Farber Cancer Institute.
Located at 450 Brookline Ave, Boston, MA 02215. Free parking in the Yawkey Center garage,
entrance on Jimmy Fund Way.
Contact: Tracey Cook, 617-632-4450, [email protected]: http://video.dfcionline.org/accordent/WeinbergSymposium110117
Biography:Dr. James (Jay) M. Bradner, M.D., hasbeen President of Novartis Institutes forBioMedical Research, Inc. at NovartisAG since March 1, 2016. Dr. Bradner isthe Founder of C4 Therapeutics, Inc. Heis a Scientific Founder of AcetylonPharmaceuticals, TetraLogic Researchand Development Corporation, SyrosPharmaceuticals, Inc. and Tensha Ther-apeutics, Inc.
He serves as Staff Physician atDana-Farber Cancer Institute. He servesas Physician-Scientist, Chemical Biol-ogy Group, Broad Institute; AssociatePhysician, Brigham and Women’s Hos-pital; and Instructor of Medicine, Har-vard Medical School.
He leads a chemical biology groupat the Broad Institute investigating cel-lular function of histone deacetylasesand the role of autophagy in hemato-logic malignancies. His group appliesforward and reverse chemical geneticplatforms, high-content screening andsmall-molecule microarrays for ligands
modulating autophagy. Dr. Bradner is Associate Director of
the Center for the Science of Therapeu-tics (CSofT) at the Broad Institute wherehe has worked since 2004. He serves asan Assistant Professor of Medicine atHarvard Medical School. He was an As-sociate Professor at Harvard MedicalSchool.
He serves as a Director of TenshaTherapeutics, Inc. He serves as a Direc-tor of TetraLogic Research and Devel-opment Corporation. He serves as aMember of Scientific Advisory Board atAcetylon Pharmaceuticals, Inc. Heserved as a Member of the SupervisoryBoard at Qiagen NV since June 2015until December 31, 2015. He served asa Director and Member of Scientific Ad-visory Board at Syros Pharmaceuticalsfrom April 2013 until October 2015. Hehas served as a Member of ScientificAdvisory Board at Agios Pharmaceuti-cals, Inc., since November 24, 2008.
Dr. Bradner has co-authored morethan 130 scientific publications and 30United States Patent applications. He isattending physician in the Department
of Hematology-Oncology at the Dana-Farber Cancer Institute. Dr. Bradner re-ceived his AB in Biochemical Sciencesfrom Harvard University in 1994, hisM.D. from the University of Chicago in1999 and his M.M.S. from HarvardMedical School. u
Abstract: “Dr. Bradner will discuss the relationshipbetween academia and industry in cancerdrug development. He will provide aspecific emphasis on pediatric oncologydrug development. He will provide rel-evant examples from his own laboratorywork focused on new targets. This willinclude targets involved in determiningstructure of chromatin (complex ofDNA and proteins that constitute chro-mosomes) and transcription (convertingDNA into an RNA message). A key ex-ample will be bromodomain inhibitors,a novel class of drugs with anti-canceragents now in clinical trials.” u
8 The Nucleus October 2017
The 2017 edition of the German Exchange Program (GEX)included twelve student−delegates from nine colleges and uni-versities in the Northeastern Section. Among them were 8graduate students:
• Zhehui Li, Boston College• Alfred Burney-Allen, Boston University• Gina Kim, Boston University• Brendan Mattingly, Boston University• Reem Telmesani, Boston University• Li Zha, Harvard University• Sita Gurung, University of Massachusetts, Dartmouth• Min Song, University of New Hampshire
and four undergraduates:• Amelia McCue, Saint Anselm College• Jordan Mattheisen, Simmons College• Jasper Du, Tufts University• Margaret, Klureza, Wellesley College
The delegates were selected from among 25 applicants basedon the quality of their research presentations and interviewsconducted in late November, 2016. They were accompaniedon the trip to Germany by two former participants in the GEXprogram, Emel Adaligil and Andrew Scholte, and by GEXCo-chair Tom Gilbert. Also joining the delegation was Bren-dan Mattingly’s father, Daniel Mattingly from Jacksonville,FL, who served as a guide for his sight-impaired son.
The group began its journey on Saturday, March 25, withan overnight flight from Boston to Zurich and a connectingflight to Frankfurt – at least that was the plan. Unfortunately,a short connection time coupled with a late departure fromBoston and slow passport control in Zurich Airport led to thegroup missing its connecting flight. Fortunately, enough seatswere available on the next flight to Frankfurt, and our group(and luggage) reached Frankfurt airport in mid-afternoon onSunday. There they were greeted by Dr. Elisabeth Kapatsina,head of the Education Department of the German ChemicalSociety (GDCh). Elisabeth served as principal host and guidefor the group during their time in Germany.
A half-hour train ride brought the group to Mainz, a cityof 200,000 located west of Frankfurt at the confluence of theMain and Rhine Rivers. Mainz is the home of JohannesGutenberg University, Mainz (JGU), which was the site of theprincipal activity of the trip: participation in a research sym-posium organized by the Young Chemists Committee of theGDCh (Jungchemikerforum or JCF).
After checking into their hotel the group headed to a wel-coming dinner hosted by members of the JCF, who were re-sponsible for organizing and running the research symposium
and who did a marvelous job of hosting the delegates duringtheir time in Mainz. Among them were Valentina Breising,John Haupt and Benjamin Breitenbach. At dinner the NE-SACS contingent also met delegates from Russia, Brazil,Nigeria, and Vietnam who were attending the JCF symposiumthrough the International Young Chemists Network (IYCN).These students traveled with our group during the remainderof time in Germany.
On Monday our delegates were up early for a trip toDarmstadt and the world headquarters of Merck KGaA. Therethey learned about the history of this pharmaceutical andchemical company and about its scientists’ recent advances indeveloping anti-cancer drugs, innovative photovoltaic tech-nology, and organic light-emitting diodes (OLED) for ultra-
2017 NESACS/GDCh Exchange Trip toMainz, Germanyby Tom Gilbert
The welcome dinner took place in a Mainz restaurant that is also a brew-ery. The beer was fresh and delicious, which contributed to the manysmiles in this photo.
Conclusion of the trip to Merck headquarters in Darmstadt provided aphoto opportunity that showcased the sunny, warm weather the group en-joyed in Germany. continued on page 10
The Nucleus October 2017 9
Sunday, October 15, 2017 – Museum of Science, BostonPhyllis A. Brauner Memorial Lecture by Dr. Bassam Shakhashiri
Dr. Bassam Shakhashiri is a Professor of Chemistry at the University of Wisconsin-Madison andis the William T. Evjue Distinguished Chair for the Wisconsin Idea. Professor Shakhashiri hascaptivated audiences with his scientific demonstrations at a variety of locations includingBoston’s Museum of Science, the National Academy of Sciences and the Smithsonian’s NationalAir and Space Museum in Washington.
Taking place in Cahners Theatre (2nd floor, Blue Wing) at 1:00pm and 4:00pm
*Admission to the museum is required. Free tickets to Dr. Shakhashiri’s show will be availableon a first come, first serve basis. Tickets are available via advance reservation. To reserve tickets,please contact the NESACS secretary via email [email protected] before October 10, 2017.Tickets will be available for pick-up in the lobby of the museum at the ACS table.
Hands-on Activities Related to Geochemistry & Much MoreNCW guest educators will be available from 11:30am – 3:30pm to perform demonstrations andassist in hands-on activities suitable for museum visitors of all ages.
Saturday October 28, 2017 – Boston Children’s MuseumCome join our NCW volunteers from 11am – 4pm for hands-on activities suitable for all ages
10 The Nucleus October 2017
thin TV displays. Our tour included a presentation aboutOLED technology from Prof. Dr. Herwig Buchholz, Merck’sGlobal Head of Chemistry R&D.
On Tuesday morning the group traveled to the enormous(over 7,000 people work there) Sanofi research and manufac-turing center at Frankfurt-Höchst. A bus tour of the sprawlingfacility included stops at several R&D and manufacturing fa-cilities. Among them: the plant that produces the world’s sup-ply of fexofenadine hydrochloride, the active ingredient in theallergy medicine Allegra.
In the afternoon, the group toured downtown Frankfurt,and took in the view from the top of one of the city’s tallestbuildings. Later they visited the historic buildings and publicspaces near the Römer, which has served as Frankfurt’s cityhall since the early 1400s. That evening the group dined atApfelweinwirtschaft Wagner, a famous restaurant in Frankfurtthat is noted for its homemade apple wine.
On Wednesday the group stayed in Mainz, touring thechemistry research and teaching facilities of the JohannesGutenberg University, Mainz, which has more chemistry stu-dents (over 1100) than any other German university. The tourincluded the JGU’s extensive NMR, polymer chemistry andphysical chemistry research facilities. It was followed by atour of the Max-Planck Institute for Chemistry, which is lo-cated on the campus of JGU . That tour featured a presentationon the institute’s research activity on the chemistry of Earth’satmosphere, lithosphere and hydrosphere. After-lunch activi-ties included a tour of the university’s TRIGA nuclear reactorand a presentation on the research it supports. That eveningthe JCF conference began with a welcome reception wherethe group had its first opportunity to connect with the morethan 300 young chemists attending the conference from Ger-many and many other countries.
Thursday, Friday and Saturday morning were filled witha blend of plenary lectures from well-known senior chemistsand oral and poster presentations from student participants.Two of our delegates, Reem Telmesani and Li Zha, were in-vited to give oral presentations. All presentations were deliv-ered in English, although Li gave his acknowledgment andthanks to our JCF hosts in German, and received an enthusi-astic round of applause for doing so. The official conferencedinner was held on campus Friday night followed by a latenight/early morning celebration at a club near ancient Romanbaths on the east side of Mainz. Many of our delegates hadlittle sleep that night.
On Saturday morning six of our delegates presented their re-search during the final poster session, which was followed bythe symposium’s closing ceremony. During this event Reemreceived the Best Oral Presentation award. Saturday afternoonwas a time for souvenir shopping for many delegates, fol-lowed by a farewell dinner for them and the IYCN delegateshosted by GDCh. Gifts were exchanged as our delegatesthanked our JCF and GDCh colleagues for their gracious hos-pitality and for a rewarding and enjoyable experience. Towardthe end of dinner a cake was served to help celebrate BrendanMattingly’s birthday.
NESACS/GDCh TripContinued from page 8
The group gathers after their tour of the expansive Sanofi campus atFrankfurt-Höchst.
The NESACS group takes in the view of Frankfurt and its surroundingsfrom the top of one of its tallest skyscrapers. Our members (front rowfrom left): Emel Adaligil, Sita Gurung, Jordan Mattheisen, AndrewScholte, and Jasper Du. Back row: Tom Gilbert, Brendan Mattingly, LiZha, Amelia McCue, Reem Telmesani, Maggie Klureza, Gina Kim, ZhehuiLi, Min Song, Alfred Burney-Allen, and our remarkable host, ElisabethKapatsina. continued on page 11
Delegates and their new JCF friends toast a successful and very enjoyableconference.
The Nucleus October 2017 11
The Sunday return flights (againthrough Zurich) were thankfully un-eventful. Conversations at the airportsand on the planes were filled with dele-gate comments about what a great edu-cational and cultural experience theyhad had.Epilogue: On the Saturday followingtheir return from Germany, GEX dele-
gates participated in the NortheasternSection Younger Chemists Committee’sNortheast Student Chemistry ResearchConference at Harvard University. Dur-ing the awards ceremony at the conclu-sion of the conference, Reem Temesaniwas presented the Most Promising Fe-
male Scientist Award and Jasper Du re-ceived the Outstanding UndergraduateStudent Poster Award. u
NESACS/GDCh TripContinued from page 10
On the way to our farewell dinner, hosted byGDCh, in downtown Mainz
Reem and her Best Oral Presentation Award
Reem andJasper withtheir awardcertificatesat theNSYCC conference
For late breaking news, job postings and the latest meeting and event
information please visit us at
WWW.NESACS.ORG
12 The Nucleus October 2017
The Northeastern Local Section waspresented with the Outstanding Sustain-ability Activities ChemLuminary Awardat the 19th Annual Ceremony (Our Vol-unteers and Their Monumental Impact)on August 22, 2017, at the ACS nationalmeeting in Washington, D.C.
NESACS received the award fromthe Committee on Environmental Im-provement (CEI) for hosting a day-longworkshop in partnership with itsYounger Chemists Committee, PfizerPharmaceuticals, and the New EnglandScientists and Teachers for Sustainabil-ity (NESTS) Association that featuredtalks from research chemists who applygreen chemistry principles in their dailylives, and educators who develop lessonplans and strategies about green chem-istry. NESACS had received a LocalSection Sustainability ProgrammingGrant in 2016 to make the event possi-ble. This CEI-sponsored award recog-nizes a local section that has introduceda new and outstanding program promot-ing sustainability at the local level.
Details about the workshop, whichwas held on November 5, 2016, at theIntegrated Science Center at UMass-Boston, were published earlier: R. Borg,The NUCLEUS, 95, 2 (January 2017).The collaboration between Pfizer andUMass-Boston was initiated by Prof.Jonathan Rochford of the UMB Chem-istry Department.
NESACS was also a finalist for sixother awards for its activities in 2016based on self-nominations in its annualreport.• Outstanding Local Section Career
Program (Committee on Economicand Professional Affairs, CEPA), wonby the Colorado Local Section.
• Outstanding Local Section YoungerChemists Committee (YoungerChemists Committee, YCC), won bythe Savannah River Local Section.
• Outstanding or Creative Local SectionYounger Chemists Committee Event(Younger Chemists Committee, YCC),won by the Colorado Local Section.
• Outstanding Collaboration Between aLocal Section and Division (Commit-tee on Local Section Activities andCommittee on Divisional Activities,LSAC and DAC), won by theLouisiana Local Section.
• Outstanding Local Section IndustryEvent (Corporation Associates, CA),won by the East Central Illinois LocalSection.
• Best Overall Local Section MinorityAffairs Committee (Committee onMinority Affairs, CMA), won by theOrange County Local Section. u
NESACS ReceivesChemluminary Award
With the ChemLuminary Award: (l-r) Sofia San-tos (Massachusetts General Hospital/HarvardMedical School; NSYCC Past-Career Chair),Caitlyn Mills (Northeastern; NSYCC Chair), RayBorg (currently at UC-Santa Barbara; NSYCCPast-Outreach Coordinator, NESTS Past-Chair),Javier Magano (Pfizer), Catherine Rawlins(Northeastern; NSYCC Past-Chair), MeredithWard (UMass-Boston; NESTS Education Chair).
Photo by Timothy Bergeron
ACSAnnounces2018AwardsThe following NESACS members havebeen named winners of awards admin-istered by the ACS for 2018. With theexception of the Cope ScholarsAwardees, these recipients will be hon-ored at the Awards Ceremony on Tues-day, March 20, 2018, in conjunctionwith the 255th ACS National Meeting inNew Orleans, LA.ACS Award in Applied Polymer Sci-ence sponsored by Eastman Chemical:Paula T. Hammond, M.I.T.ACS Award in Pure Chemistry spon-sored by the Alpha Chi Sigma Fraternityand the Alpha Chi Sigma EducationalFoundation: Mircea Dinca, M.I.T.Ronald Breslow Award for Achieve-ment in Biomimetic Chemistry spon-sored by the Ronald Breslow AwardEndowment: David R. Liu, HarvardUniversity.Arthur C. Cope Scholar Awards spon-sored by the Arthur C. Cope Fund:Emily P. Balskus, Harvard University;James P. Morken, Boston College.Nobel Laureate Signature Award forGraduate Education in Chemistrysponsored by Avantor™ PerformanceMaterials: Aleksandr V. Zhukhovitskiy(Student), University of California,Berkeley, and Jeremiah A. Johnson (Pre-ceptor), M.I.T.Also, the James Flack Norris Awardin Physical Organic Chemistry spon-sored by NESACS will be presented toCynthia J. Burrows, University of Utah.In addition, our Brauner Memorial Lec-turer at National Chemistry Week willbe honored:James T. Grady–James H. StackAward for Interpreting Chemistry forthe Public sponsored by ACS: BassamZ. Shakhashiri, University of Wiscon-sin-Madison. u
Q. Exactly, how many awards andscholarships does NESACS sponsor?
A) One b) Two c) Many
www.nesacs.org/awards
Your one-stop source to career-relatedlinks in the Chemical Sciences
WWW.NESACS.ORG/CAREERS
2017NESACS 50, 60 and70-yearMembers50-Year MembersJay Alan Bouwens, Henry ThomasBrown, Stephen James Brudno, RobertLaurent Caret, Linda Jean Charpentier,Gerald Leslie Cooper, Andrew JosephCorcoran, Guy Alexander Crosby, Ken-neth L. Demerjian, Nelson McFarlandFrew, A. K. Ganguly, Thomas R.Gilbert, Darlene Janice Goldstein,James Albert Golen, George WilliamGoodloe, John Francis, Grogan, JayKenneth Gunther, Robert B. Hall, DavidErnest Hamer, Robert Hanninen, JudithHerzfeld, Joyce Lefever Illinger,Howard Craig Jordi, Theodore FrancisJula, Fredrick James Kull Arthur LucienLafleur, Louis Lieto, Samuel WilliamPage, Dimite J. Rasmussen, Marvin J.Rudolph, Reinhard Sarges, Roger ErvinShamel, David George Shaw, LawrenceSheftel, Helen R. Steele, Sophia R. Su,Keith Tornheim, Jeffrey Alan Ulman,Ioannis Vassiliou Yannas60-Year MembersRobert J. Allen Nicholas Ashford,Joseph A. Baglio, Thomas Joseph Brett,Sam S. Brody, L. W. Duncan, Earl Ju-lian Forman, Francis H. Girard, SydneyGordon, Leon E. Granahan, RichardSamuel Herd, Dudley Robert Her-schbach, William J. Holloway, RichardHadley Holm, Albert W. Horlbeck, Mar-tin Isaks, Lee A. Johnson, Margaret E.Langmuir, Sheldon Markofsky, EdwardW. Merrill Joseph S. Panto, Frank LouisPilar, Charles P. Riley, James F. Riordan,John L. Roebber, Ronald H. Rogstad,Louis Shuster, Augustine Silveira, PerSten Stensby, Donald L. Townsm DavidL. Williams70-Year MembersMaurice Peter Bellis, Elias James Corey,Jr., John L. Ennis, Martin E. Epstein,Hanna Friedenstein, Gerald LouisMcLeod u
The Nucleus October 2017 13
MariettaHaegSchwartz1961–2017
From the Editor: Marietta HaegSchwartz passed away on September 6,2017 at Winchester Hospital at the ageof 55. Marietta was a major contributorto NESACS and the ACS and served inmany capacities.
She was NESACS Chair-Elect andProgram Chair in 2007 and was NESACSChair in 2008. She served on the Boardof Publications (1999-2003). Mariettaserved the Section as a Councilor, Chairof the Norris Award Committee and asChair of the Education Committee.
Marietta will be deeply missed byher many friends and colleagues in thelocal and national chemistry communi-ties.
Marietta was born in St. Cloud,Minnesota, the oldest child and onlydaughter of six children. Raised on asmall farm in Minnesota, Marietta grad-uated from Cathedral High School in St.Cloud in 1979, College of St. Benedictin 1983, and received her Ph.D. from theUniversity of Wisconsin – Madison in1988.
In the fall of 1988, Marietta movedto Boston, and took a job at UMASSBoston as an Assistant Professor in theChemistry Department. She worked atUMASS for almost 30 years, more re-cently serving as an Associate Dean inthe College of Science and Math. Mari-etta also served as the Director of theStudent Services Center, and Co-Direc-tor of the UTeach Program. Marietta,
with a down to earth perspective, madea positive impact on her studentsthrough her love for chemistry.
Marietta was a capable, self-reliant,and confident woman. She was a mem-ber of the American Chemical Society,and supported women in chemistrythrough the Women Chemists Commit-tee. As a mother, Marietta volunteeredwithin the Cub Scouts and Boy Scoutsguiding Graham and Ian as they both be-came Eagle Scouts. She was actively en-gaged in the Wakefield community as avolunteer for the Farmer’s Market, 4thof July parade, and was a longtime, pas-sionate supporter of the Wakefield Inter-faith Food Pantry. Marietta sang in thechoir at St. Joseph’s Church in Wake-field for many years. Compassionatewith a deep sense of faith and social jus-tice, Marietta cared about the future, andthe well being of others.
At home, she loved reading, watch-ing the Red Sox, Patriots, and doing jig-saw puzzles. She loved iced coffee,going out for Indian Food, or getting to-gether with friends for a cup of tea anda chat.
Although she made friends every-where she went, her roots and family inCollegeville always held a special placein her heart. She was famous for makingdozens upon dozens of cookies for herfamily, friends, or neighbors, and lovedplaying a family game of “schmear.”She will be missed, but always lovinglyremembered and admired for herwarmth, calm nature, and inner strength.
Marietta was the devoted mother ofGraham T. Schwartz of Atlanta, GA,and Ian M. Schwartz of Ft. Hood, TX.Beloved daughter of Eileen and RichardHaeg of Collegeville, MN. Dear sisterof Gregory Haeg and his wife Megan ofCollegeville, MN, Daniel Haeg of Col-legeville, MN, Benedict Haeg and hiswife Claire of Sauk Centre, MN,Christopher Haeg of Collegeville, MN,and Timothy Haeg and his wife Kelly ofCollegeville, MN. Former wife of EricSchwartz of Marblehead.
Gifts in memory of Marietta maybe made to the College of Saint Bene-dict, Attn: Haeg Scholarship for Womenin STEM, 37 S. College Ave., St.Joseph, MN 56374, or to the WakefieldInterfaith Food Pantry, 467 Main St,Wakefield, MA 01880. u
14 The Nucleus October 2017
D I R E C T O R Y
CAREER SERVICES
Updated frequently • Late-breaking news • position postingsBack issues of the Nucleus archived • Career-related Links • Awards and Scholarships
WWW.NESACS.org
The NESACS website
This work was presented as an invited talk by Mary Shultz at the Spring ACS Meeting in San Francisco and is in press in The Proceedings of the National Academy of Sciences: “Single-crystal Ih ice surfaces unveil connection between macroscopic and molecular structure,” PNAS, 2017 114= (21) 5349-5354.u
Chemist Answers 400-Year Old QuestionWe are all familiar with the hexagonal shape of snowflakes. Over 400 years ago, Kepler speculated about the microscopic buildings blocks that lead to that shape. Using a combination of electron backscatter (similar to x-rays) and large single crystal ice, chemist Mary Shultz (Tufts University) and collaborators (Dartmouth College and Max Plank, Mainz, Germany) have compellingly shown the connection illustrated below. The six points of the snowflake grow from the flat sides of the chair-form hexagon of the basal face. The snowflake points align with the crystallographic a axes shown as hot spots in the electron backscatter data. The graphic below reflects three scales: the macroscopic snowflake (blue line), the molecular structure (red tube model), and the electron scattering diffraction (density plot).
The Nucleus October 2017 15
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Index of AdvertisersEastern Scientific Co. ......11Micron, Inc. .....................15NuMega Resonance Labs15Organix, Inc. ....................15PCI Synthesis...................15Robertson Microlit Labs..15Tyger Scientific, Inc. .......15
Check the NESACS home pagefor late Calendar additions:http://www.NESACS.orgNote also the Chemistry Department webpages for travel directions and updates.These include:http://www.bc.edu/schools/cas/chemistry/s
eminars.htmlhttp://www.bu.edu/chemistry/seminars/http://www.brandeis.edu/departments/chem
istry/events/index.htmlhttp://chemistry.harvard.edu/calendar/upco
minghttp://www.northeastern.edu/cos/chemistry/
events-2/http://chemistry.mit.edu/events/allhttp://chem.tufts.edu/seminars.htmlhttp://engineering.tufts.edu/chbe/newsEven
ts/seminarSeries/index.asphttp://www.chem.umb.eduhttp://www.umassd.edu/cas/chemistry/http://www.uml.edu/Sciences/chemistry/Se
minars-and-Colloquia.aspxhttp://www.unh.edu/chemistry/eventshttps://www.wpi.edu/academics/departmen
ts/chemistry-biochemistry
October 2Prof. Mike McBride (Yale)“Viedma Ripening: How a New Old Mechanismof Crystal Growth Achieves Efficient Deracem-ization.”Brandeis, Gerstenzang 1214:00 pmProf. Dustin Maly (Univ. of Washington-Seattle)Harvard, Pfizer Lecture Hall4:15 pm
Prof. Brad Pentelute (MIT)Boston University, Metcalf, Rm 1134:00 pm
October 3Dr. Douglas Beshore (Merck) Tufts, Pearson, Rm. P1064:30 pm
October 4Prof. Anna Mapp (Univ. of Michigan-AnnArbor)“Using Organic Molecules as Probes to Under-stand How Genes are Regulated.”Northeastern, 129 Hurtig Hall12:00 noon
October 5Prof. Chen Yang (Boston University)Boston College, Merkert 1304:00 pm
October 10Prof. Amy Keating (MIT) Tufts, Pearson, Rm. P1064:30 pm
October 11Prof. Connie Lu (University of Minnesota)Harvard, Pfizer Lecture Hall4:15 pmProf. Clara Santato (Ecole Polytechnique deMontreal)“Electrical and Optical Properties of OrganicSemiconductors.”Northeastern, 129 Hurtig Hall12:00 noon
October 12Dr. Tamas Balla (NIH)“New revelations about the role of PI4Ks in or-ganizing membrane lipid composition.”WPI, Gateway Park Room 100212:00 noonProf. Xiaowei Zhuang (Harvard)Boston College, Merkert 1304:00 pm
October 13Prof. Guy Lloyd-Jones (Univ. of Edinburgh)Boston College, Merkert 1304:00 pm
October 16Prof. Dirk Trauner (NYU)Harvard, Pfizer Lecture Hall4:15 pmProf. M. Kevin Brown (Indiana Univ.-Bloomington)Boston University, Metcalf, Rm 1134:00 pm
October 17Prof. Michael Neidig (Univ. of Rochester) Tufts, Pearson, Rm. P1064:30 pmProf. Connie Lu (Univ. of Minnesota)Boston College, Merkert 1304:00 pm
October 18Prof. Alex Gorfe (Univ. of Texas)“Dynamics of Ras Proteins in Solution and inMembrane.”Northeastern, 129 Hurtig Hall12:00 noon
October 19Prof. Matthew Lockett (Univ. of North Car-olina-Chapel Hill) Tufts, Pearson, Rm. P1064:30 pmProf. Tomoki Ogoshi (Kanazawa University)MIT, Room 6-1204:00 pmProf. Kami Lee Hull (Univ. of Illinois)Boston College, Merkert 1304:00 pm
October 20Prof. Tomoki Ogoshi (Kanazawa University) “Synthesis of Pillar-Shaped Macrocyclic Com-pounds ‘Pillar[n]arens’ Providing Supramolec-ular Assemblies.”Harvard, Pfizer Lecture Hall4:15 pm
October 23Prof. Daniel Kahne (Harvard) “Molecular Machines that Build Membranes.” Harvard, Pfizer Lecture Hall4:15 pmProf. Jennifer Stockdill (Wayne State)Boston University, Metcalf, Rm 1134:00 pm
October 24Prof. Timothy Swager (MIT) Tufts, Pearson, Rm. P1064:30 pmProf. Igor Alabugin (Florida State)Boston College, Merkert 1304:00 pm
October 25Prof. Gang Han (Univ. of Massachusetts)“Nanotechnology, Neuroscience, Bioimaging,and Therapy.”Northeastern, 129 Hurtig Hall12:00 noon
October 26Prof. Anna K. Mapp (Univ. of Michigan)Dr. Artis Klapars (Merck)“Invention of New Synthetic Methods for theManufacture of Active Pharmaceutical Ingredi-ents at Merck.”MIT, Room 6-1204:00 pmProf. Michael P. Pollastri (Northeastern)“Approaches and adventures in kinase inhibitorrepurposing for tropical disease drug discovery.”WPI, Gateway Park, Room 100212:00 noonProf. Katherine Willets (Temple)Boston College, Merkert 130 4:00 pm
October 30Prof. Dan Raleigh (Stony Brook University)“Islet amyloidosis and the biophysical basis ofbeta cell death.”Brandeis, Gerstenzang 1214:00 PMProf. Yimon Aye (Cornell)Harvard, Pfizer Lecture Hall 4:15 pm
Notices for The NucleusCalendar of Seminars should besent to:Xavier Herault, email:[email protected] u
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