0

10

20

30

40

50

60

AHI 0-5 AHI 5-10 AHI >10

20% 23%

57%

Andreja Šajnić1

1University Hospital Center Zagreb, Clinic for Pulmonary Diseases Jordanovac, Croatia.

Aims of the study

TABLE 1. The distribution of patients by categories OSA according to measured value AHI. (N=97)

Arterial hypertension F=75% M=74%

History of Myocardi. Infarct. F=0% M=6%

History of Stroke F=0% M=6%

Diabetes mellitus F=12% M=28%

BMI ≥30 F=87% M=79%

Daily ABG PaO2<80mmHg F=75% M=89%

≤ 0mmHg 1-10mmHg 11-20mmHg Differences of PaO2

26% 48% 26% Initial application of PAP

Methods TABLE 1. There was noted a large number of patients with AHI≥10 (57%). This can be explained by the fact that it is still a large number of patients who have not been diagnosed in the previous years.

TABLE 2. Shows that a high percentage of HA, BMI≥30 and daily ABG PaO2<80mmHg was present in women and men, while DM, IM and Stroke was higher percentage in men than in women.

Conclusion

Results

We have demonstrated a high percentage of comorbidities in OSA patients. The highest frequency of medical states in patients with OSA were obesity, arterial hypertension and daily PaO2<80mmHg. It has shown success with initial application PAP devices. PAP therapy is effective in daily hypoxemia correction.

Obstructive sleep apnea (OSA): Effect of initial application of PAP therapy on daily arterial partial pressure of oxygen.

TABLE 2. Displays distribution of certain medical conditions for male and female patients with OSA AHI≥10 (therapy group) (N=55)

TABLE 3. Overview of the distribution of patients according to the difference of PaO2 after the initial application PAP therapy (N=38)

TABEL 3. Shows the distribution of 38 patients who had a successful initial application PAP therapy according to the in PaO2 difference. It followed the difference between daily PaO2 and PaO2 after overnight application of PAP therapy. 74% of patients had improvement in PaO2 after just one night of PAP application.

OSA has a high and rising prevalence in the general adult population. The prevalence of OSA in adults is estimated to be 6%, 75% of whom remain undiagnosed. 1 1. Selim, B., Won, C., Yaggi, H. K. Cardiovascular Consequences Of Sleep Apnea. Clin Chest Med. 2010; 31: 203 – 220

ABG was done only in patients who had a successful initial implementation of PAP therapy (N=38), the findings were compared with the values of ABG, which were made during admission into the clinic.

In patients who entered the therapy group (N=55), PSG recording was done with the use of PAP therapy (auto titration). The success of the initial implementation of PAP implied use for a whole night.

Medical diagnoses were obtained from the medical documentation of patients and based on tests made. BMI was calculated from obtained measurements of height and weight (kg / m2 = BW (kg) / BH (m) 2).

AHI is a result of PSG. All patients underwent a complete full night PSG (Alice IV or LE5 Respironics) and laboratory and functional tests at the clinic (chest X-ray, ECG, routine blood tests, ABG and spirometry).

The study group was consisted of patients who came to the polysomhnograpy (PSG) for OSA valuation (N=97). Patients with AHI<5 are considered to be negative, AHI 5-10 are considered to be positive but not included in the therapeutic group, AHI≥10 are considered positive which enters the therapeutic group. In each patient, we recorded the AHI, BMI, age, sex, comorbidities, ABG analysis and the success of the initial implementation of PAP therapy.

Aims of the research conducted at the Clinic for Pulmonary Diseases was to determine: 1) The distribution of patients by categories OSA according to measured value AHI, 2) OSA in interaction with other medical diagnoses, 3) Demonstration of successful application PAP therapy. In our research are the results for the year 2009.