obesity in pregnancy - minnesota acnm · 2018-11-01 · 1. define appropriate preconception and...
TRANSCRIPT
Obesity in Pregnancy
Optimizing care through evidence,
education and support
Interprofessional work group created guidelineAnn Forster Page, DNP, APRN, CNM, FACNM
Lisa Gill, MD, MFM
Allison Welle, RN, BSN, Nurse-Midwife DNP student
Credit to other members of the work group:
Katherine Jacobs, MD, MFM
Samantha Hoffman, MD, FACOG
Sabrina Burn, MD, OB/GYN Resident
Tanya Melnik, MD, IM
No Disclosures
Objectives1. Define appropriate preconception and early pregnancy screening for women with
obesity.
2. Identify techniques to optimize communication when discussing evidence-based
recommendations for a healthy pregnancy with women with obesity.
3. List antenatal fetal screening recommendations for pregnant women with obesity.
4. Discuss evidence-based recommendations for preparation for labor and birth and
timing of delivery for pregnant women with obesity.
5. Describe risks and preventative measures during the postpartum period for pregnant
women with obesity.
Prevalence
❏ Of women aged 20-39, 40% have a BMI of > 30 in the US
❏ Prevalence is higher in non-Hispanic black and Hispanic women
❏ Number of women with obesity has continued to rise in the US over the past 45
years
Maternal risksPregnancy loss
Gestational diabetes
Gestational hypertension
Preeclampsia
Anxiety
Depression
Obstructive sleep apnea
Increased gestational weight gain
Labor induction
Cesarean birth
Surgical site infections
Neonatal risksCongenital anomalies
Stillbirth
Preterm birth
LGA
Shoulder dystocia
NICU admission
Lower breastfeeding initiation
Early breastfeeding cessation
Neonatal hypoglycemia
Increased risk of obesity in adulthood
What does maternity care look like for providers and patients with obesity?
Experiences of Pregnant Women with Obesity ❏ Most receive no counseling on gestational weight gain
❏ Desire advice on gestational weight gain
❏ Lack of information leads them to look to other sources for information
❏ Many falsely believe that there were no increased risks to pregnancy or that there
was nothing they could do to minimize risks
❏ Contributes to disappointment in their prenatal care
❏ Can sense provider’s discomfort discussing topic
❏ Vulnerable to judgemental care from practitioners
❏ 19% would avoid future appointments, 21% would seek a new provider (Puhl,
2012)
Experiences of Providers❏ Typically avoid conversation about weight
❏ Wait for patient to bring it up or look for cues from patient
❏ Brought up too late after patient has already gained weight
❏ When it is discussed, tend to give guidelines not consistent with Institute of
Medicine
❏ Key barriers identified by providers:
❏ Lack of knowledge
❏ Negative consequence of intervening
❏ Lack of resources
Techniques to Optimize Communication
Person Centered Language
Open the conversation- Ask for permission to discuss
- Let them tell their story
Word choice- ‘Weight’
- ‘Unhealthy weight’
- ‘BMI’
Use motivational interviewing
- Find out goals, motivations
- Teachable moment
Culturally appropriate suggestions
- Consider finances,
transportation, favorite foods,
etc.
Be aware of your bias❏ Harvard’s Project Implicit
❏ https://implicit.harvard.edu/implicit/selecta
test.html
❏ Obesity Action Coalition
❏ https://4617c1smqldcqsat27z78x17-wpengi
ne.netdna-ssl.com/wp-content/uploads/We
ight_Bias_in_Healthcare_9_12_17-without-
bleed.pdf
Replace judgement with intellectual curiosity
Gestational Weight Gain
Recommended weight gain during pregnancy should be based on
weight at first visit if care is initiated during 1st trimester
Gestational Weight Gain❏ Many women exceed gestational weight gain recommendations
❏ New research shows lower risks for mothers and babies with these guidelines:
❏ No association between low gestational weight gain or weight loss with low birth weight
or small for gestational age neonates and NICU admissions (Bogaerts, Ameye, Martens, & Devliege, 2015)
❏ DIFFERENT than other previous studies showing a positive correlation between
weight loss and SGA
BMI 30-34.9 11-20 lbs
BMI 35-39.9 2-11 lbs
BMI 40+ No weight gain is optimal
(Faucher & Barger, 2015)
Exercise and Diet❏ Exercise is SAFE
❏ No increased risk of preterm birth with vigorous exercise (Wang et al., 2017)
❏ Regular, vigorous exercise provides health benefits
❏ Does seem to be associated with decreases in GWG and lower risk of GDM, C/S,
and macrosomia
❏ Poorly used interventions and high drop-out rates
❏ No specific diet shown to decrease GWG in patients with obesity
❏ Dietary interventions appear to benefit women with a normal or overweight BMI
but might not be sufficient to prevent adverse perinatal outcomes in women with
obesity
The Guideline
1st Trimester❏ 1st trimester dating ultrasound recommended
❏ Discuss neonatal risks and genetic screening options
❏ Early GCT by 12 weeks
❏ Add Hgb A1C with new OB labs
❏ Refer to nutritionist or counsel on food choice
❏ Consider Vit D levels and supplements
❏ Consider 5mg dosing for folic acid
❏ Screen for obstructive sleep disorder, consult or referral
❏ CNM practice inclusion considerations
Educational Handout for
Patients
Sleep Apnea Evaluation
Referral for sleep study: home study vs in clinic overnight
BMI ≥ 30 plus one:
- Snoring
- Observed apnea
- Hypertension
Condition Odds Ratio (95%
CI) with obesity
GDM 4.13 (3.54-4.82)
Preeclampsia 5.32 (4.43-6.37)
Pulmonary
Embolism
14.06 (6.10-32.4)
Cardiomyopathy 19.12 (15.12-24.18)
Hospital stay > 5
days
3.07 (2.59-3.63)
In hospital
mortality
7.84 (3.28-18.74)
Modified STOP
2nd Trimester
❏ Anatomy survey
❏ GCT and other routine labs
❏ Track weight gain, review weight tracking graph in epic with
patient
❏ Discuss and encourage exercise, yoga, walking
❏ Positive reinforcement!
3rd Trimester❏ Return OB visits q 2wks starting at 28 wks
❏ Consider growth and presentation check us at 32- 36 wks
❏ Recommend weekly antenatal testing at 36 wks for BMI ≥ 40
❏ Consider Anesthesia consult BMI ≥ 35
❏ Discuss considerations for labor:
❏ Impact for success of TOLAC
❏ IV access in labor, AMTSL, increased risk for PPH
❏ Intermittent Auscultation: criteria excludes IA with a BMI ≥ 35
❏ Many waterbirth guideline criteria excludes BMI ≥ 35
❏ Induction of labor should be offered at 39 weeks gestational age for women with a BMI
≥ 40.
❏ VTE prevention plans
Labor and Birth❏ Encourage upright and mobility
❏ Recognized possible slower progress
❏ EFM; Monica telemetry prefered, consider IUPC if unable to pick up
contractions.
❏ Anesthesia early consult on admission in labor: airway evaluation and discussion
for BMI ≥35
❏ shoulder dystocia and PPH increased risk
Operating Room:
❏ Have “Traxi” (pannus retractor) available
❏ Ancef 3gm
❏ 0-PDS for fascial closure
Postpartum, 0-7 days❏ Increased breastfeeding support
❏ VTE prevention
❏ Pharmacologic anticoagulation should be considered in women with BMI ≥30
admitted antepartum for an expected stay of 72 hours or more.
❏ All women with a BMI ≥ 35 undergoing cesarean delivery for any indication
should receive pharmacologic anticoagulation within 24 hours of delivery for
the course of their hospitalization.
❏ All women with BMI ≥ 40 undergoing vaginal delivery with an anticipated
hospital stay of 72 hours should receive pharmacologic thromboprophylaxis for
the duration of their postpartum hospitalization.
Postpartum, 1-8 weeks❏ 2 hr GTT as needed
❏ Encourage appropriate return to exercise
❏ Refer to weight management clinic as appropriate
❏ Refer to Internal Med if other comorbidities exist, i.e. hypertensive disorders
❏ Birth control: consider decreased efficacy of OCP
Ultrasound in Obesity
Ultrasound in obesity• Miss rate for anomalies increases up to 20% in obesity
• Detection rate improves with gestational age (up to a point)
• Consider anatomic survey at 20 weeks to optimize detection
rate
Stillbirth rates• At all gestational ages, pregnancy loss is higher in obese
women
• “Dose-dependent”
• Mechanism is not well understood
What risk is too much?
To test or not to test?❏ No consensus
❏ Does not appear to cause increased risk of iatrogenic
early delivery (<39 weeks) or cesarean delivery
❏ No clear evidence that antenatal testing improves
outcomes
Recommendation• ⩾
•••
Delivery timing❏ Again…..no consensus
❏ Decision analyses and cost effectiveness studies
recommend delivery at 39 weeks
❏ No randomized controlled trials for obese women to
date
But….❏ Increased risks exist for
❏ Failed induction
❏ Cesarean delivery (vs spontaneous labor)
❏ Wound infection
❏ Prolonged wound healing
❏ VTE with prolonged hospitalization
Recommendation● Women with class 3 obesity (BMI ⩾ 40) should be offered induction of labor in
the 39th week of gestation
○ Why?
■ Stillbirth risk begins to rapidly increase
■ Neonatal death rate falls below the stillbirth rate
● Compared with expectant management, IOL has a lower cesarean rate at 39 weeks
○ Decision analysis data
■ Improved cesarean rate, decreased health care costs with IOL at 39 weeks for obese patients
Gill et al. J Mat Fet Neonat Med. 2017
VTE Prophylaxis❏ VTE risk increased 2-3 fold in obese women
❏ New guidelines from California recently published
❏ Cesarean or
❏ Vaginal delivery
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CMQCCCalifornia
Maternal
Quality
Care Collaborative
2017
Questions
ReferencesACOG. (2015). Practice bulletin: Obesity in pregnancy. American College of Obestricians and Gynecologists, 123(5), 1118–1132.
https://doi.org/doi.org/10.1097/AOG.0000000000001048ACOG. (2016). Weight Gain During Pregnancy. The American College of Obstetricians and Gynecologists, 548(548), 1–3.
https://doi.org/10.1002/14651858.CD001877.Bogaerts, A., Ameye, L., Martens, E., Devlieger, R. (2015). Weight loss in obese pregnant women and risk for adverse perinatal outcomes.
Obstetrics and Gynecology, 125(3), 566-575.Carlson, N.S., Leslie, S.L., & Dunn, A. (2018). Antepartum care of women who are obese during pregnancy: Systematic review of the current
evidence. Journal of Midwifery and Women’s Health, 63 (3), 259-272.Ching, R., Ma, W., Schmidt, M. I., Tam, W. H., Mcintyre, H. D., Catalano, P. M., & Alegre, P. (2018). Clinical management of pregnancy in the obese
mother : Before conception, during pregnancy, and post partum. The Lancet Diabetes and Endocrinology, 4(12), 1037–1049. https://doi.org/10.1016/S2213-8587(16)30278-9
Davis, A. (2015). Pandemic of pregnant obese women: Is it time to re-evaluate antenatal weight loss? Healthcare, 3(3), 733–749. https://doi.org/10.3390/healthcare3030733
Deputy, N. P., Sharma, A. J., Kim, S. Y., & Olson, C. K. (2018). Achieving Appropriate Gestational Weight Gain: The Role of Healthcare Provider Advice. Journal of Women’s Health, 0(0), jwh.2017.6514. https://doi.org/10.1089/jwh.2017.6514
Dutton, H., Borengasser, S. J., Gaudet, L. M., Barbour, L. A., & Keely, E. J. (2018). Obesity in pregnancy. Medical Clinics of North America, 102(1), 87–106. https://doi.org/10.1016/j.mcna.2017.08.008
Faucher, M. A., & Barger, M. K. (2015). Gestational weight gain in obese women by class of obesity and select maternal / newborn outcomes : A systematic review. Women and Birth, 28, e70–e79.
Knight-agarwal, C. R., Williams, L. T., Davis, D., Davey, R., Shepherd, R., Downing, A., & Lawson, K. (2016). The perspectives of obese women receiving antenatal care : A qualitative study of women’s experiences. Women and Birth, 29, 189–195.
Kominiarek, M. A., Gay, F., & Peacock, N. (2015). Obesity in pregnancy: A qualitative approach to inform an intervention for patients and providers. Maternal and Child Health Journal, 19(8), 1698–1712. https://doi.org/10.1007/s10995-015-1684-3
Kominiarek, M. a, & Chauhan, S. P. (2016). Obesity before, during, and after pregnancy: A review and comparison of five national guidelines. American Journal of Perinatology, 1(212), 433–441. https://doi.org/10.1055/s-0035-1567856
Lavender, T., & Smith, D. M. (2015). Seeing it through their eyes: A qualitative study of the pregnancy experiences of women with a body mass index of 30 or more. Health Expectations, 19(2), 222–233. https://doi.org/10.1111/hex.12339
Lindhardt, C. L., Rubak, S., Mogensen, O., Lamont, R. F., & Joergensen, J. S. (2013). The experience of pregnant women with a body mass index >30 kg/m 2 of their encounters with healthcare professionals. Acta Obstetricia et Gynecologica Scandinavica, 92(9), 1101–1107. https://doi.org/10.1111/aogs.12186
Liu, P., Xu, L., Wang, Y., Zhang, Y., Du, Y., Sun, Y., & Wang, Z. (2016). Association between perinatal outcomes and maternal pre-pregnancy body mass index. Obesity Reviews, 17(11), 1091–1102. https://doi.org/10.1111/obr.12455
Muktabhant, B., Lawrie, T. A., Lumbiganon, P., Laopaiboon, M., Ta, L., Lumbiganon, P., & Laopaiboon, M. (2015). Diet or exercise, or both, for preventing excessive weight gain in pregnancy. Cochrane Database of Systematic Reviews, (6), CD007145. https://doi.org/10.1002/14651858.CD007145.pub3.www.cochranelibrary.com
Phelan, S. (2010). Pregnancy: a “teachable moment” for weight control and obesity prevention. American Journal of Obstetrics and Gynecology, 202(2), 135.e1-135.e8. https://doi.org/10.1016/j.ajog.2009.06.008
Stengel, M. R., Kraschnewski, J. L., Hwang, S. W., Kjerulff, K. H., & Chuang, C. H. (2012). “What my doctor didn’t tell me”: Examining health care provider advice to overweight and obese pregnant women on gestational weight gain and physical activity. Women’s Health Issues, 22(6), e535–e540. https://doi.org/10.1016/j.whi.2012.09.004
Wang, C., Wei, Y., Zhang, X., Zhang, Y., Xu, Q., Sun, Y., … Yang, H. (2017). A randomized clinical trial of exercise during pregnancy to prevent gestational diabetes mellitus and improve pregnancy outcome in overweight and obese pregnant women. American Journal of Obstetrics and Gynecology, 216(4), 340–351. https://doi.org/10.1016/j.ajog.2017.01.037
Yeo, S., Walker, J. S., Caughey, M. C., Ferraro, A. M., & Asafu-Adjei, J. K. (2017). What characteristics of nutrition and physical activity interventions are key to effectively reducing weight gain in obese or overweight pregnant women? A systematic review and meta-analysis. Obesity Reviews, 18(4), 385–399. https://doi.org/10.1111/obr.12511
Louis JM, Mogos MF, Salemi JL, Redline S, Salihu HM. Obstructive Sleep Apnea and Severe Maternal-Infant Morbidity/Mortality in the United States, 1998-2009. Sleep [Internet]. 2014;37(5):843–9. Available from: https://academic.oup.com/sleep/article-lookup/doi/10.5665/sleep.3644
Louis JM, Auckley D, Sokol RJ, Mercer BM. Maternal and neonatal morbidities associated with obstructive sleep apnea complicating pregnancy. Am J Obstet Gynecol [Internet]. 2010;202(3):261.e1-261.e5. Available from: http://dx.doi.org/10.1016/j.ajog.2009.10.867
Rice JR, Larrabure-Torrealva GT, Fernandez MAL, Grande M, Motta V, Barrios Y V., et al. High risk for obstructive sleep apnea and other sleep disorders among overweight and obese pregnant women. BMC Pregnancy Childbirth [Internet]. 2015;15(1):1–8. Available from: http://dx.doi.org/10.1186/s12884-015-0633-x
Antony KM, Agrawal A, Arndt ME, Murphy AM, Alapat PM, Guntupalli KK, et al. Association of adverse perinatal outcomes with screening measures of obstructive sleep apnea. J Perinatol. 2014;34(6):441–8.
Lockhart EM, Ben Abdallah A, Tuuli MG, Leighton BL. Obstructive Sleep Apnea in Pregnancy. Obstet Gynecol [Internet]. 2015;126(1):93–102. Available from: http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:landingpage&an=00006250-201507000-00016
Ghaffari N, Srinivas SK, Durnwald CP. The multidisciplinary approach to the care of the obese parturient. Am J Obstet Gynecol [Internet]. 2015;213(3):318–25. Available from: http://dx.doi.org/10.1016/j.ajog.2015.03.001
Facco FL, Ouyang DW, Zee PC, Grobman WA. Development of a pregnancy-specific screening tool for sleep apnea. J Clin Sleep Med. 2012;8(4):389–94.
Creanga AA, Berg CJ, Syverson C, Seed K, Bruce FC, Callaghan WM. Pregnancy-related mortality in the United States, 2006-2010. Obstet Gynecol. 2015;125(1):5–12.
Palmerola KL, Brock CO, D’Alton ME, Friedman AM. Compliance with mechanical venous thromboproembolism prophylaxis after cesarean delivery. J Matern Neonatal Med. 2016;29(19):3072–5.
Main EK, McCain CL, Morton CH, Holtby S, Lawton ES. Pregnancy-related mortality in California. Obstet Gynecol. 2015;125(4):938–47.
Quinones J, James D, Stamilio D, Cleary K MG. Thromboprophylaxis after cesarean delivery: a Decision Analysis. Obs Gynecol. 2005;106:733–40.
Baeten JM, Bukusi EA, Lambe M. Pregnancy complications and outcomes among overweight and obese nulliparous women. Am J Public Health. 2001;91(3):436–40.
Poston L, Caleyachetty R, Cnattingius S, Corvalán C, Uauy R, Herring S, et al. Preconceptional and maternal obesity: epidemiology and health consequences. Lancet Diabetes Endocrinol [Internet]. 2016;4(12):1025–36. Available from: http://linkinghub.elsevier.com/retrieve/pii/S2213858716302170
Mission JF, Marshall NE, Caughey AB. Obesity in pregnancy: a big problem and getting bigger. Obstet Gynecol Surv. 2013;68(5):389–99.
Crane, Stephen S, Wojtowycz, Martha A, Dye, Timothy D, Aubry, Richard H, Artal R. Association Between Pre-pregnancy Obesity and the Risk of Cesarean Delivery. Obstet Gynecol. 1997;89:213–6.
Marchi J, Berg M, Dencker A, Olander EK, Begley C. Risks associated with obesity in pregnancy, for the mother and baby: A systematic review of reviews. Obes Rev. 2015;16(8):621–38.
Chu SY, Kim SY, Lau J, Schmid CH, Dietz PM, Callaghan WM, et al. Maternal obesity and risk of stillbirth: a metaanalysis. Am J Obstet Gynecol. 2007;197(3):223–8.
Yao R, Ananth C V., Park BY, Pereira L, Plante LA. Obesity and the risk of stillbirth: A population-based cohort study. Am J Obstet Gynecol [Internet]. 2014;210(5):457.e1-457.e9. Available from: http://dx.doi.org/10.1016/j.ajog.2014.01.044
Stephansson O, Dickman PW, Johansson A, Cnattingius S. Maternal weight, pregnancy weight gain, and the risk of antepartum stillbirth. Am J Obstet Gynecol. 2001;184(3):463–9.
Nohr EA, Bech BH, Davies MJ, Frydenberg M, Henriksen TB, Olsen J. A Study Within the Danish National Birth Cohort. Obstet Gynecol. 2005;106(2):11–3.
Yao R, Schuh BL, Caughey AB. The risk of perinatal mortality with each week of expectant management in obese pregnancies. J Matern Neonatal Med [Internet]. 2017;0(0):1–8. Available from: https://doi.org/10.1080/14767058.2017.1381903
Hermesch AC, Allshouse AA, Heyborne KD. Body Mass Index and the Spontaneous Onset of Parturition. Obstet Gynecol. 2016;128(5):1033–8.
Higgins CA, Martin W, Anderson L, Blanks AM, Norman JE, McConnachie A, et al. Maternal Obesity and its Relationship With Spontaneous and Oxytocin-Induced Contractility of Human Myometrium In Vitro. Reprod Sci [Internet]. 2010;17(2):177–85. Available from: http://journals.sagepub.com/doi/10.1177/1933719109349780
Lee VR, Darney BG, Snowden JM, Main EK, Gilbert W, Chung J, et al. Term elective induction of labour and perinatal outcomes in obese women: Retrospective cohort study. BJOG An Int J Obstet Gynaecol. 2016;123(2):271–8.
Gill L, Holbert M. Computational model for timing of delivery in an obese population. J Matern Neonatal Med [Internet]. 2018;31(4):469–73. Available from: https://doi.org/10.1080/14767058.2017.1288207
Benacerraf, Beryl. The use of Obstetrical Ultrasound in the Obese Gravida. Sem in Perinatology. 2013;37 (345-347).
Dashe et al. Maternal Obesity Limits the Ultrasound Evaluation of Fetal Anatomy. J Ultrasound Med 2009; 28:1025-1030.
Romary et al. The Role of Early Gestation Ultrasound in the Assessment of Fetal Anatomy in Maternal Obesity. J Ultrasound Med 2017; 36:1161-1168.
Nohr et al. Pre-pregnancy Obesity and Stillbirth: a study within the Danish national birth cohort. Obstet Gynecol 2005; 106:250-9.