nucleotides and amino acids
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Nucleotides and Amino Acids. PR 613 Structural Biology I Dr. Eric Wickstrom. Structure dictates function. Nucleic Acids. Triple helix. Southern Northern. Catalytic RNA. Antiparallel B-form (Southern) double helix. - PowerPoint PPT PresentationTRANSCRIPT
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Nucleotides and Amino Acids
PR 613 Structural Biology I
Dr. Eric Wickstrom
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Structure dictates function
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Nucleic Acids
Triple helix
Southern Northern
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Catalytic RNA
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Antiparallel B-form (Southern) double helix
Ring stacking and hydrophobic repulsion stabilize helix. Hydrogen bonds permit close approach, but don’t add stability!
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Dynein TcTex1
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C to N, over the bridge
Sidechain on the left in an L-amino acid
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Aromatic (-orbital) amino acids
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pK 4 pK 4
pK 10.5
pK 8
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pK 10.5 pK 12.5 pK 6
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Sperm whale myoglobin
helix3.6 aa/turn5.4 Å/turn1.5 Å/aa
8 helices
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sheet2.0 aa/turn7 Å/turn3.5 Å/aa
Prealbumin
16 sheets
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-turns