nuclear envelope
TRANSCRIPT
Nuclear receptorsNuclear receptors
Emilie Lilford
Group 11
Biochemical definition of a receptor
Chemical change physiological change biological function
LigandLigand
ReceptorReceptor
Types of receptors and locations:• Cell surface receptors • Receptors located in the cytoplasm• Nuclear receptors Nuclear receptors
Ligands of nuclear receptors
Structures of some nuclear receptor ligands and their corresponding receptors name.
Structural organization
Sandwich filling model of ligand binding domain (LBDLBD)
DNA binding domain (DBDDBD) – structure of the human progesterone receptor
What is a Domain?
• Independent subunits of proteins.• Between 25 -500 amino acids in length. • Independently stable and folded.• Can diverge and converge.• Domain represents function. Domain represents function.
Domains of nuclear receptors
• Zinc fingers• LBD• DBD • N-terminal + C-terminal
How nuclear receptors work.