n a t o l i . c o m

NP- RD30r o t a r y R & D t a b l e t p r e s s

D E S I G N E D F O R S C A L E — U P

SOLVE TABLET DEFECTS Discover potential tableting issues before production

MINIMAL API Determine formulation characteristics for successful tableting using minimal API

DWELL TIME Easily replicate dwell time of production presses

NATOLI NP-RD30 R&D TABLET PRESS EASILY SOLVES FORMULATION AND SCALE-UP CHALLENGES

DATA ACQUISITION AND ANALYSIS SOFTWARE SIMPLIFIES SCALE-UP

Natoli Engineering is quickly becoming the leader in R&D tablet presses with this next-generation rotary tablet press. Designed to help solve formulation and scale-up challenges, the NP-RD30 rotary R&D tablet press replicates the design and functionality of a production press. The turret velocity of the NP-RD30 can reach that of production presses, meaning dwell time can be more accurately established during research and development. Five rolling casters allow for easy mobility.

3.50

8.25

5.25 11.0 mm 55 15.0

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0.00 3.37 3.37

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0.00

0.00

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0.00

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1.0

0

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Direct

GranulesDirect (pre)

Ejec

tion

(N)

Compression (MPa)

The NP-RD30 Natoli AIM™ Plus main data screen provides an easy-to-interpret visual interface for quick assessment of formulation performance. Operator can control press speed and quickly view minimum and maximum pre-compression, compression, and ejection forces in real time.

The NP-RD30’s integrated Natoli AIM™Plus data acquisition/analysis and operating system software is designed to ease formulation and process development and minimize production issues during scale-up.

The NP-RD30 gives you the option to run only the number of stations you need, saving time and amount of formulation used.

• Provides tablet press scalability parameters• Calculates tensile strength for round, convex, and

oblong tablets• Quickly measures and evaluates tablet

formulations and properties• Provides projected data from formulation

changes• Reduces trial and error• Evaluates compaction properties of APIs and

potential formulations• Measures and reports data for tabletability,

compactibility, compressibility, and strain rate profiles

• Generates reports for manually entered data from friability, dissolution, and hardness testers

• Provides data to optimize lubrication levels with ejection/compression profiles (Fig. 1)

Natoli AIM™Plus Capabilities Speed Tablet Scale-up

DATA ACQUISITION• Monitors and records peak values for critical

events during tableting process.

DATA LIBRARY• Includes database of production press

specifications for most press models and manufacturers.

• Provides accurate scale-up data for specific production press using preloaded information and R&D data input.

DWELL TIME ASSESSMENT• Establishes ideal production dwell time for varying

tablet design specifications and tooling head flats.

TANGENTIAL VELOCITY ASSESSMENT• Determines tangential velocity using pitch circle

diameter and RPM ranges.• Analyzes dwell and compaction time at varying

turret speeds.• Provides manufacturers with live R&D data

normalized for their specific production press.

COMPACTION TIME ASSESSMENT• Analyzes tangential velocity, compression roller

diameter, and punch head configuration to calculate compaction time parameters needed in production.

NP-RD30 Features: • Integrated Natoli AIM™ Plus data acquisition and

analytical software

• User-friendly 21" HMI touchscreen

• USB port for easy data transfer

• CFR 21 Part 11–compliant

• Identical pre- and main compression roll diameter

• Pre- and main compression, ejection, and take-off force monitoring

• Independent overload for pre- and main compression

• Automatic and dosing weight control

• Patented Fast-Fill cam design

• Standard batch reporting and error and alarm tracking

• Built-in calibration tool

• Containment-ready separate compression zone

• Dual-paddle, variable-speed feeder design

• Optional security and HID badge capabilities

Natoli AIM™Plus data analysis and operating system software:

Fig. 1 LUBRICATION OPTIMIZATIONThe Natoli AIM™ Plus Lubrication Optimization Feature provides the data to maximize tablet robustness and disintegration while minimizing production issues such as overblending and tablet capping.

RUN ONLY THE NUMBER OF STATIONS

YOU NEED

NATOLI ENGINEERING: Dedicated to Supporting Our Industry

Natoli Engineering Company is the world-renowned leader in tablet press tooling manufacturing. But we are far more. Founded on the uncompromising principle to manufacture and deliver the highest quality products at a fair price with exceptional customer service, Natoli continues to build on 40 years of innovation and industry leadership.

ATTRIBUTES 4+4 STATION 8 STATION 10 STATION

Punch Type EU 19, EU D/TSM B, D EU D/TSM D EU 19/TSM BDepth of Fill 20—22mm (.787—.866") 22mm (.866") 20mm (.787")

Maximum Round Diameter 17.5—23.8mm (.6875—.9375") 23.8mm (.9375") 17.5mm (.6875")

Shaped Major Dimension 19.0—25.4mm (.7500—1.000") 25.4mm (1.000") 19.0mm (.7500")

Pre-compression Force 10kN

Main Compression Force 60kN

Pre- and Main Upper Punch Penetration 0—6mm

Pre-Compression Data Collection 10kN Strain Gage Sensor to accurately collect lower pre-compression data

Vertical Pressure Roller Movement Proper upper and lower punch alignment allowing longer simultaneous dwell

Pitch Circle Diameter 200mm

Dwell Time Range 91—9.1ms

Tangental Velocity Range 105—1047mm/sec

Turret Speed 10-100 RPM

Machine Total Weight 2,835 lbs

Tablets Per Hour 2,400—24,000 4,800—48,000 6,000—60,000

NP-RD30 R&D TABLET PRESS SPECIFICATIONS:

Learn more about Natoli’s NP-RD30 R&D tablet press at www.natoli.com/tablet-presses or contact your Natoli representative today! +1 636.926.8900

Form 1122-N, 6/18 Copyright © 2018, Natoli Engineering Company , Inc.Natoli AIM™ is a trademark of Natoli Engineering Company, Inc.

NATOLI ENGINEERING COMPANY, INC. natoli.com • info@natoli.com • +1 636.926.8900