Novo seedsChanging the world through entrepreneurship

Oslo Cancer Cluster Summer Meeting

Novo SEEDS20-06-2016

Novo Seeds gives budding ideas the chance to develop into unique – and life-saving products for the future…

2 20-06-2016

Could your research lead to better and life-changing treatments in the future?

3 20-06-2016

• Unmet need for the product/therapy

• Is the target novel and scientific rationale promising

• Superiority over existing solutions

• Quality of research and data

• Stage of research (test of idea, proof-of-concept)

• IP, patentability etc.

• Development time and cost, regulatory issues, commercial strategy

• Plan and budget

• Team expertise, experiences, network and motivation

From research project to a novel life changing treatment…

Who needs it

What’s the data

Can it be done

Novo Seeds is driven by helping researchers transforming amazingresearch into better and safer treatments…

4 20-06-2016

Building science Making a plan Taking it to patients

How do we help you on the jorney...

5 20-06-2016 * Varies

Exploratory pre-seed grants Pre-seed grants Seed investments

up to DKK 700,000

up to 12 months

up to DKK 3.5 M

up to 18 months

8-12

up to DKK 60 M*

to exit

5-8

Financial:

Time:

2016 target:

Testing of interesting ideas

IP analysis Commercial analysis

PoC studies Business plan creation Setting the team

Lead identification Prototype development Clinical PoC

Building science Making a plan Taking it to patients

We are a partner

We can bring advice and network

We believe a trustful relationship is important, because a start-up rarely develops as

expected

You will be in contact with us on a regular basis or during the board meetings

We will support you in key decisions

We give more than just the check...

6 20-06-2016

Novo Seeds – The early-stage Investment arm of NOVO A/S

7 20-06-2016

We invest in life science, devices and industrial biotech We focus mainly on Europe We are not a strategic investor for NN

60bn$

NOVO NORDISK FOUNDATION04.11.2015

YOU plant the seeds. We're here to help them grow!

8 20-06-2016

Christina TrojelCTOH@NOVO.DK

Diana MuftigDMUF@NOVO.DK

Selected cancer-focused start-ups from our portfolio

9 20-06-2016

NOVO NORDISK FOUNDATION04.11.2015

Never hesitate to reach out..

10 20-06-2016

Novo Seeds receives proposal in ppt, word doc

(E-mail/ conferences / meetings)

Novo Seeds performs high level evaluation of quality, novelty, risk/reward

Novo Seeds invites for project presentation if project appear interesting and within scope

Follow up questions, dialogue, meetings

Dilligence Phase and decision of pre-seed grant or seed investment

Thank you

20-06-2016

11

Quick guideline – we like to see elements described below..

12 20-06-2016

1.Good science and quality data: this underpins the application. Data with relevant controls that clearly shows the effect and convinces us that this is an interesting target/MoA/molecule/device/diagnostic assay etc2.Comprehensive presentation: present all relevant data to tell the story. Everyone at Novo Seeds has a scientific background and convincing data is a large part of a good application 3.Don’t: Please don’t send a list of publications expecting us to read through it and find the most important facts. Sell your story actively! 4.Do: send a few pivotal articles that validate your findings, e.g show that the target is validated 5.Background: give a background to the indication/area but focus on how your data is unique in the setting and how it addresses something novel. It is preferential if the team has a knowledge of where the scientific community as well as the commercial pipeline is in regards to the indication and can articulate how their approach is unique 6.Differentiation and uniqueness: what differentiates your invention to existing treatments as well as most obvious competing products in development. How does your product address the medical need in a way that no other product does and in what exact patient population does it do so. Consider outlining a Target Product Profile 7.Market/IP/Other analysis: if there is a previous analysis done please include it in the presentation, but a general overview (eg. “Cancer kills many people” or ) has low value-add8.Team: briefly present the team and relevant credentials 9.Plan going forward: A plan showing what the next steps are, including scientific activities, collaborations etc and what the pre-seed grant would be used for. This can always be a point of discussion and collaboration if the grant is approved but we would like to see that team is in the driving seat

13 20-06-2016

Examples of Novo Seeds portfolio companiesDiscovery Lead Optimisation Pre-clinical Clinical Phase I Clinical Phase II

Acesion PharmaAtrial fibrillation

PcoveryAnti-fungal

Forendo PharmaEndometriosis

GalectoFibrosis

IntheraOncology

GlionovaGlioblastoma

RSPR PharmaAllergic asthma

AffiniconMacrophage targeted drugs

AdeniumAnti-microbial

IO BiotechImmuno-oncology

LysogeneGene therapy

AvilexNeuroprotection

MinervaXGBS vaccine

PoC Prototype Development PMA/510k Sales

ReapplixWound care

DenatorProtein stabilization

Discovery / feasibility Processdevelopment

Pilot scale Commercial scale

BiosyntiaVitamins by fermentation

Small molecules

Proteins peptides

MedTech

Bio-industrial