november 16–17, 2006 - vanderbilt university · 11:45 am lunch marriott courtyard - marriott...

November 16–17, 2006Leighton AuditoriumHarold W. Siebens Medical Education BuildingMayo Clinic, Rochester, Minnesota

Presented by:Mayo Clinic Division of Cardiovascular DiseasesMayo Medical Laboratories

This conference is co-sponsored by the Functional Genomics & TranslationalBiology Interdisciplinary Working Group of American Heart Association.

tableof

contentsGENERAL INFORMATION

n Meeting Your Education Needs ....................................................................................4

n Conference Description ..............................................................................................4

n Conference Learning Objectives ..................................................................................4

n Intended Audience ......................................................................................................4

n Date and Location ......................................................................................................4

n Record of Attendance ..................................................................................................4

n Educational Grants......................................................................................................4

n Conference Faculty ......................................................................................................5

PROGRAM SCHEDULE

n November 16–17, 2006..............................................................................................7

REGISTRATION AND TRAVEL INFORMATION

n Registration ................................................................................................................9

n Cancellation Policy ......................................................................................................9

n Travel ........................................................................................................................9

n Lodging Accommodations ............................................................................................9

n Parking ......................................................................................................................9

n Social Programs........................................................................................................10

n Recreation and Leisure Activities................................................................................10

n Biomarkers in Cardiovascular Risk: State of the Art Registration Form..........................11

800-533-1710 n MAYO MEDICAL LABORATORIES 33

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BIOMARKERS OF CARDIOVASCULAR RISK: STATE OF THE ART n NOVEMBER 16–17, 20064

MEETING YOUR EDUCATION NEEDSIn selecting this conference, you will be takingadvantage of more than 100 years of research, education, and clinical practice extended throughMayo Foundation subsidiaries, which includeMayo Clinic, Mayo Clinic College of Medicine,and Mayo Medical Laboratories.

Relevant, stimulating content, delivered bythought-leading presenters, are hallmarks of Mayo conferences. You will also have ample opportunity to network with peers within your field.

Our professional staff works diligently to ensure that the subject matter, venue, and faculty combine to create a rewarding and enjoyableexperience that benefits you, your organization, and the patients you care for. Register now toassure attendance at this conference.

CONFERENCE DESCRIPTIONThis conference will provide an overview ofadvances in the use of proteomic markers in cardiovascular risk stratification in asymptomaticindividuals. The conference will include information on emerging markers, current approaches to cardiovascular risk stratification, biomarker development and assay validation, regulatory issues, and perspectives from industry.

CONFERENCE LEARNINGOBJECTIVESUpon completion of the conference, participantsshould be able to:n Describe how atherosclerosis biology is

relevant to developing new biomarkers ofcardiovascular risk

n Provide an update on how markers ofinflammation, thrombogenicity, and other etiologicpathways may improve risk prediction

n Discuss use of multiplex biomarker panels and statistical approaches to interpret results ofmultiplex testing

n Provide an update on the latest platforms for multimarker testing

n Explain the transitioning of a new biomarker toward a clinically useful test and discussperspectives from industry and regulatory bodies

DISCLAIMERAttendance at this Mayo conference does not indicate nor guarantee competence or proficiency in the performance of any procedures that may be discussed or taught in this course.

INTENDED AUDIENCEThis conference is designed for cardiovascularspecialists, preventive cardiologists, internists,research fellows, scientists, and clinical chemists.It is intended for individuals interested in the useof circulating biomarkers in cardiovascular risk stratification.

DATE AND LOCATIONThe Biomarkers of Cardiovascular Risk: State of theArt conference will be held November 16–17, 2006.Conference headquarters will be in LeightonAuditorium on the second floor of the Harold W. Siebens Medical Education Building,Mayo Clinic, 100 Second Avenue SW, Rochester, Minnesota.

RECORD OF ATTENDANCEA record of attendance for 11.25 contact hours willbe provided to attendees.

Physicians may claim AMA PRA Category 2 Credit TM

for participating in this activity; however, pleasenote that this is a self-recorded action. Physiciansshould self-claim credit for appropriate AMA PRACategory 2TM activities on their AMA PRA certificate application form. For additional information, pleaserefer to the AMA Physician’s Recognition AwardBooklet (2006 revision) on the American MedicalAssociation’s Web site (www.ama-assn.org).

EDUCATIONAL GRANTSThis conference is supported in part from fundingfrom NIH/NHLBI grant HL081331. However, theviews and opinions expressed at the conferencedo not necessarily reflect those of theDHHS/NIH/NHLBI.

At the time of this printing, a complete listing of commercial supporters was not available.Appropriate acknowledgement will be given to all supporters at the time of the meeting.

Exhibits will be available for viewing at all scheduled breaks.

generalinformation


CONFERENCE FACULTY

COURSE DIRECTORSGeorge G. Klee, MD, PhDChairDivision of Experimental Pathology Mayo ClinicProfessor of Laboratory MedicineMayo Clinic College of MedicineRochester, Minnesota

Iftikhar J. Kullo, MDConsultantDivision of Cardiovascular Diseases Mayo ClinicAssociate Professor of MedicineMayo Clinic College of Medicine Rochester, Minnesota

MAYO FACULTYJohn C. Burnett Jr., MDConsultantDivision of Cardiovascular Diseases Mayo ClinicProfessor of Medicine and PhysiologyMayo Clinic College of MedicineRochester, Minnesota

Allan S. Jaffe, MDConsultantDivision of Cardiovascular Diseases Mayo ClinicProfessor of MedicineMayo Clinic College of Medicine Rochester, Minnesota

GUEST FACULTYN. Leigh Anderson, PhDFounder and CEOPlasma Proteome InstituteWashington, D.C.

Gerd Assman, MD, FRCPDirectorInstitute for Clinical Chemistry and

Laboratory MedicineDirectorArteriosclerosis Research InstituteUniversity of Münster Münster, Germany

Christie M. Ballantyne, MDDirectorCenter for Cardiovascular Diseases PreventionDirectorThe Maria and Alando J. Ballantyne, MDAtherosclerosis Clinical Research LaboratoryBaylor College of MedicineHouston, Texas

R. Dennis Cook, PhDProfessorSchool of StatisticsUniversity of Minnesota Minneapolis, Minnesota

Shah Ebrahim, BM BS, MSc, DM, FRCP, FFPHMDepartment of Epidemiology & Population HealthLondon School of Hygiene & Tropical MedicineLondon, United Kingdom

Dawn GrataloSenior Research AssociateIllumina CorporationWallingford, Connecticut

Steven I. Gutman, MD, MBASupervisory Medical OfficerFood and Drug AdministrationRockville, Maryland

Paul Holvoet, PhDAtherosclerosis and Metabolism UnitDepartment of Cardiovascular DiseasesFaculty of MedicineCatholic University - LeuvenLeuven, Belgium

Mehmood Khan, MD, FACESenior Vice PresidentMedical & Scientific AffairsTakeda PharmaceuticalsLincolnshire, Illinois

Hanno Langen, MDHead of Biology Research and Proteomics InitiativeRoche Center for Medical GenomicsF. Hoffmann-La RocheBasel, Switzerland

Peter Libby, MDChiefCardiovascular MedicineBrigham and Women’s HospitalMallinckrodt Professor of MedicineHarvard Medical SchoolBoston, Massachusetts

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Chang Liu, PhDAssociate Professor Department of Electrical and Computer EngineeringUniversity of Illinois at Urbana-ChampaignUrbana, Illinois

Gordon Lowe, MD, FRCP, DScProfessor of Vascular MedicineGlasgow Royal InfirmaryUniversity of GlasgowGlasgow, Scotland, UK

John A. Moon, PhDVice PresidentTechnologyIllumina CorporationWallingford, Connecticut

Robert Parson, MS, MAS, CRE, CQEDirector of BiostatisticsBiosite IncorporatedSan Diego, California

John J. QuinnStaff SpecialistIllumina CorporationWallingford, Connecticut

Vasan S. Ramachandran, MD, DM, FACC Associate EditorCirculationProfessor of MedicineBoston University School of MedicineSenior Investigator and Co-Director of

Echocardiography & Vascular LaboratoryFramingham Heart StudyFramingham, Massachusetts

Pothur R. Srinivas, PhD, MPHDivision of Cardiovascular DiseasesNational Heart Lung and Blood InstituteBethesda, Maryland

Peter W. F. Wilson, MDProfessor of MedicineDepartment of Medicine, Cardiology DivisionEmory University School of MedicineAtlanta, Georgia

FACULTY DISCLOSUREAs a provider accredited by ACCME, Mayo Clinic College of Medicine (Mayo School of CME) must ensure balance,independence, objectivity, and scientific rigor in its educational activities. Thus, safeguards against commercial bias have been put in place. Coursedirector(s), planning committee, faculty, and all others whoare in a position to control the content of this educationalactivity are required to disclose all relevant financial relationships with any commercial interest related to thesubject matter of the educational activity. Faculty also willdisclose any off-label and/or investigational use of pharmaceuticals or instruments discussed in their presentation. Disclosure of this information will be published in course materials so that participants in theactivity may formulate their own judgments regarding thepresentation.


programschedule


THURSDAY, NOVEMBER 16, 2006

7:00 AM Registration and BreakfastLeighton Auditorium Foyer, Siebens Building, Second Floor

7:50 AM Welcome and Opening RemarksDavid L. Hayes, MD, Chair, Division of Cardiovascular Diseases, Mayo Clinic

8:00 AM OverviewGeorge G. Klee, MD, PhD, and Iftikhar J. Kullo, MD

Session I: Atherosclerosis Biology, Inflammation, and ThrombosisSession Chair: Christie M. Ballantyne, MD

8:15 AM Keynote Lecture: Cardiovascular Biomarkers: Insights from Atherosclerosis BiologyPeter Libby, MD

8:45 AM Markers of Inflammation

Christie M. Ballantyne, MD

9:10 AM Markers of Thrombogenicity

Gordon Lowe, MD, FRCP, DSc

9:35 AM Questions/Discussion

9:55 AM Break

Session II: Novel MarkersSession Chair: John C. Burnett Jr., MD

10:10 AM Natriuretic Peptides as Markers of Cardiovascular RiskJohn C. Burnett Jr., MD

10:35 AM Markers of Myocardial Injury in Asymptomatic SubjectsAllan S. Jaffe, MD

11:00 AM Markers of Oxidative StressPaul Holvoet, PhD

11:25 AM Questions/Discussion11:45 AM Lunch

Marriott Courtyard - Marriott Hotel

Session III: Coronary Heart Disease (CHD) Risk AlgorithmsSession Chair: Peter W. F. Wilson, MD

12:45 PM CHD Risk Algorithms: New DirectionsPeter W. F. Wilson, MD

1:10 PM CHD Risk Assessment: The European PerspectiveGerd Assman, MD, FRCP

1:35 PM Assessing Clinical Utility of BiomarkersVasan S. Ramachandran, MD, DM, FACC

2:00 PM Questions/Discussion2:20 PM Break

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dule Session IV: Proteomics, Genomics, and Imaging

Session Chair: Iftikhar J. Kullo, MD

2:35 PM Discovery and Validation in ProteomicsN. Leigh Anderson, PhD

3:00 PM Biomarkers and Genomics: Mendelian RandomizationShah Ebrahim, BM BS, MSc, DM, FRCP, FFPHM

3:25 PM Integrating Proteomics, Genomics and ImagingIftikhar J. Kullo, MD

3:50 PM NHLBI Proteomics InitiativesPothur R. Srinivas, PhD, MPH

4:15 PM Questions/Discussion4:45 PM Adjourn

FRIDAY, NOVEMBER 17, 2006

7:00 AM BreakfastLeighton Auditorium Foyer, Siebens Building, Second Floor

7:50 AM Welcome and Opening RemarksFranklin Cockerill III, MD, Chair, Department of Laboratory Medicine and Pathology,Mayo Clinic

8:00 AM OverviewGeorge G. Klee, MD, PhD, and Iftikhar J. Kullo, MD

Session V: Validation and Clinical Utility of Cardiovascular BiomarkersSession Chair: George G. Klee, MD, PhD

8:15 AM Bioinformatics and Biomarker ValidationGeorge G. Klee, MD, PhD

8:45 AM Regulatory Issues: The FDA PerspectiveSteven I. Gutman, MD, MBA

9:10 AM Cardiovascular Biomarkers: An Industry PerspectiveMehmood Khan, MD, FACE

9:35 AM Questions/Discussion10:00 AM Break

Session VI: Multiplex TechnologiesSession Chair: George G. Klee, MD, PhD

10:15 AM Biosite’s Multiple Marker Method for Diagnostic and Prognostic PanelsRobert Parson, MS, MAS, CRE, CQE

10:40 AM Illumina BeadXpress: A Novel Platform for Multiplex Detection of Proteinand Nucleic AcidsDawn Gratalo / John A. Moon, PhD / John J. Quinn

11:05 AM Chip-based Assay for Proteomic Biomarker IdentificationChang Liu, PhD

11:30 AM Questions/Discussion11:45 AM Dimension Reduction in Multiplex Testing

R. Dennis Cook, PhD12:10 PM From Proteomics Biomarker Discovery to Validation Using Multiplex Protein Assays

Hanno Langen, MD12:35 PM Questions/Discussion1:00 PM Adjourn - Box lunches


generalinformation

REGISTRATIONTo register, complete the attached registration formand return by mail or fax. The registration fee of$250 includes tuition, comprehensive course syllabus, continental breakfasts, lunches, breakrefreshments, and reception. Although it is not thepolicy of Mayo Medical Laboratories EducationDepartment to limit the number of participants, conference room facilities may necessitate closingof enrollment; therefore, early registration is stronglyadvised. Registration deadline is November 3,2006. Please indicate your e-mail address on the registration form. A letter of confirmation will be forwarded to this address upon receipt of paymentand completed registration form. Present the letterof confirmation when checking in at the meeting registration desk.

CANCELLATION POLICYIf you cancel your participation in this conference onor before November 3, 2006, your registration fee,less a $75 administrative fee, will be refunded.Mayo Medical Laboratories Education Departmentmust receive written notification of your cancellation.No refunds will be made after November 3, 2006.

TRAVELTravel arrangements are the responsibility of theparticipant.

Rochester, Minnesota, is a friendly city that greetsthousands of visitors from around the world eachyear. The city is served by a modern internationalairport with multiple flights daily from Chicago andMinneapolis via American or Northwest Airlines.Access to and from the airport is available by taxi,shuttle service, and rental car. The airport is locatedapproximately ten miles from downtown.

Attention: Several cities in the United Statesare named Rochester. When you make airlinereservations and check your baggage, be sure thatyour destination is Rochester, Minnesota (RST), andthat your baggage has been properly tagged.

For travel arrangements, you may contact LoriMunsen at Corporate Travel at 800-526-4540or 507-287-7462 (direct); 507-282-9020 (fax);or e-mail: [email protected]. Identify yourself asattending the Biomarkers of Cardiovascular Riskconference.

LODGING ACCOMMODATIONSBlocks of rooms have been secured for participantsand their guests with special conference rates atthe following hotels. To receive the special rate, you must make reservations before the room blockis filled or before the expiration date of Friday,November 3, 2006, whichever comes first.Reservations will be taken following this datebased on space and rate availability. Please identifyyourself as a participant of the Biomarkers ofCardiovascular Risk conference when making a reservation.

The Kahler Grand Hotel20 Second Avenue SWRochester, MN 55902800-533-1655 or 507-282-2581www.kahler.com$89 single/double

Rochester Marriott Hotel101 First Avenue SWRochester, MN 55902877-623-7775 or 507-280-6000www.rochestermarriott.com$119 single/double

The hotels listed above are connected by skywayand pedestrian subway to conference facilities,downtown shops, and restaurants. You may alsowish to visit the Rochester Convention and VisitorsBureau Web site (www.rochestercvb.org) for additional accommodation options. Lodging arrangements are the responsibility of the participant.

PARKINGParking is available in hotel, city, and Mayopatient/visitor ramps. The cost for parking is notincluded in the registration fee. A map indicating thelocation of parking facilities will be mailed with theparticipant confirmation letter.


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Conference ReceptionWednesday, November 15 Participants and their guest(s) are cordially invited tojoin the conference faculty for the WelcomeReception on Wednesday, November 15, from 5:30to 7:30 PM in the Marriott Ballroom. This casualreception welcomes you to Rochester, officiallyopens the conference, and offers you the perfectopportunity to connect with existing and new colleagues. Preregistration is required.

RECREATION AND LEISURE ACTIVITIES

Public tours of Mayo Clinic are provided each weekday beginning at 10 AM, except for holidays.The tours originate from Judd Auditorium, subwaylevel of the Mayo Building, and last approximately1.5 hours. The tour includes a 20-minute film on thehistory and operation of Mayo Clinic plus visits topoints of interest in the Mayo, Plummer, Hilton, andGonda buildings. Please make advance reservationsby calling 507-284-1496.

Mall of America®in Bloomington, Minnesota, is thelargest fully enclosed retail and family entertainmentcomplex in the United States. Along with 500 retailstores, restaurants, and nightclubs, the mall features The Park at MOA™, the world’s largestindoor theme park, and Underwater Adventures®Aquarium, a walk-through aquarium featuring15,000 fish. The mall is an easy 90-minute drive or shuttle ride from Rochester. Rochester Direct shuttle service will pick up at all local hotels anddepart approximately every two hours from 8:00 AM

to 8:30 PM. The cost is $34 per person same dayround-trip.

For reservations, call Rochester Direct at 800-280-9270 or visit its Web site at www.rochesterdirect.com.


c Credit Card: c Visa c MasterCard Card Number Exp Date (mm/yy)

Please specify if you have special dietary needs and indicate specific need(s):SPECIAL NEEDS

registrationform


Name (First Name, Middle Name or Initial, Last Name)

Company/Institution

Work address

City State/Country ZIP/PC

E-mail address (REQUIRED)

Telephone

c Check Enclosed (U.S. Currency) payable to Mayo Medical Laboratories

Wednesday conference welcome reception. No additional charge for participant and one guestc I will attend c I will not attend Guest: c Yes c No

Name of Cardholder (as it appears on the card) Signature of Cardholder (required) Date

Registration Fee: $250 Total Payment Enclosed:

$ ________________________

Fax

REGISTRATION

CONTACT INFORMATION

PAYMENT INFORMATION

Biomarkers of Cardiovascular Risk: State of the ArtNovember 16–17, 2006 n Rochester, Minnesota

Mail form and payment to:Mayo Medical Laboratories

Education Department3050 Superior Drive NWRochester, Minnesota 55901

Telephone: 800-533-1710 or 507-284-0286Fax: 507-284-8016Web site: www.mayoreferenceservices.org/educationE-mail: [email protected]

Registration Deadline: November 3, 2006Please print or type all information. You may duplicate this form for multiple registrations.

Degreec MD c PhD c RN c Other (please specify)

Biomarkers of Cardiovascular Risk: State of the Art

November 16–17, 2006

Leighton AuditoriumHarold W. Siebens Medical Education BuildingMayo Clinic, Rochester, Minnesota

PRESORTEDSTANDARD

US POSTAGE PAIDROCHESTER, MNPERMIT NO. 102

©2006

MC0661-63A

november 16–17, 2006 - vanderbilt university · 11:45 am lunch marriott courtyard - marriott...

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