novel technologies to assess gut health claims for carbohydrates subtheme: immunobarrier paul de vos...
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Novel Technologies to assess Gut Health Claims for Carbohydrates
subtheme: ImmunobarrierPaul de Vos (UMCG)[email protected]
Carbohydrates
Design a technology platform: Design a technology platform: to assess health benefits that meet EFSA requirement
ImmunemodulatoryFood components
Food componentsStimulating specific immunity/memory
Food enhanced stimulation ofepithelial barrier
Delivery and uptake of fragilevitamines, carbohydrates,fibers etc
Design a technology platform: Design a technology platform: to assess health benefits that meet EFSA requirement
1. HTP screening to identify immunemodulatingcarbohydrates and get insight in stage/mechanismof effect.
Design a technology platform: Design a technology platform: to assess health benefits that meet EFSA requirement
2. Testing in appropriate animal model(eg vaccination, allergy, Th1 and Th2 etc)
Successful compounds will enter subthemehuman studies (healthy/adults/infants)
Identification of specific effect:(i) Immune stimulation/suppressing/regulatory(ii) Beneficial for adults, infants, diseased or healthy subjects, male or female
1. HTP screening to identify immunemodulatingcarbohydrates and get insight in stage/mechanismof effect.
Design a technology platform: Design a technology platform: to assess health benefits that meet EFSA requirement
2. Testing in appropriate animal modelBased on results of 1. in depth analysis on mechanisms in experimental animal studies
Assays to measure effect on mucus production/function,Assays to measure effect on gut epithelium (permeability, defensins etc)Assays to measure effect on lymphocytes/dendriticsAssays to identify effects on pattern recognition receptors
Combined leads to insight how and where carbohydrates work
Vaccination, Pseudomonas, RSV, Rota, influenza, Listeria monoc., Trichinella Spiralis infection models, Allergy models (cow’s milk, henns egg, peanut allergy), DTH models, autoimmune diabetes models, asthma models, COPD models, cachexia models, inflammation models, arthritis (OA)/RA models
Design a technology platform: Design a technology platform: to assess health benefits that meet EFSA requirement
H. WichersH. SchmidtH. SavelkoulJ. DekkerJ. MesH. Schols...........
J. Garssen...........
P. de VosM.M. FaasH.J. VerkadeM. Priebe...........
(expertise: HTP systems, animals models)
Other contributing institutes/companies and participants welcome !