novel extrusion system for the encapsulation of drug delivering bio-medical micro-robots...
TRANSCRIPT
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Novel Extrusion System for the Encapsulation of Drug Delivering Bio-Medical Micro-Robots
Presentation BY:
Malcolm T. Gibson
The University of ArizonaAdvanced Micro and Nano Systems Laboratory
Dept. of Aerospace and Mechanical Engineering
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Presentation Objectives
• Introduction
• Micro-Robotics Research
• Encapsulation Methods
• The Extrusion System
• Drug Delivery Mechanisms
• Discoveries
• Conclusion
• Acknowledgements
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Introduction - Bio-Medical Micro-Robots
• Bio-Medical Micro-Robots are wireless devices for the remote delivery of drugs to systems within the human body.
• Future Applications include:
– replacing high-risk
intraocular surgeries.
– Presenting an alternative to
invasive cancer treatments.
– Targeted Drug delivery
IRIS - ETH Zurich
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Micro-Robot Research
Biomicrorobotics research is focused on building sub-mm sized, untethered robots for in-vivo medical applications.
Areas of Research:
- Structural Assembly
- Electroplating
- Drug Storage
- Encapsulation
- Bio-Polymers, Skin
- Remote Actuation
- Ultrasound
- Diffusion
- Magnetic Modulation
- Robot Propulsion
Building a complete robotic system that “swims” inside the human body is an advanced challenge and requires an innovative combination of Micro- and Nanotechnology.
IRIS - ETH ZurichIRIS - ETH Zurich
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Micro-Robot Encapsulation
Encapsulation• Purpose
• Drug Storage • Drug Capacity
• Methods • Dip Coating • Soaking • Extrusion
• Materials • Sodium Alginate• Sunflower Oil
Co-fluidic robot extrusion system.
The extrusion system utilizes drop formation via a capillary tip in a multi-phase laminar flow regime. It is designed to uniformly encapsulate micro-robots within a drug complex.
Important Concepts
• Characterizing Flow Regimes• Co-Laminar Flow Mechanics• Reynold’s Numbers• Ohnesorge Numbers• Bond and Capillary Numbers• Interfacial Forces
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Micro-Robot Drug Storage
Drug Storage - Methods and Materials
Soaks for 5 min.
Poly-l-lysine solution
Soaks for 4 min.
Polyethylenimine solution
NaAlg./ HRPDroplet
15 Min.
A
B
10 20 30 40 min.
CaCl2 solution
Drug Substitute - Horseradish Peroxidase - 44,000 Da enzyme protein
Drug Entrapment Matrix - Sodium Alginate - Cellulose fiber found in plant Cells - high strength and durability.
Surface Skin Formation - Polymer Coating - Inhibits release prior to actuation
Skin
Bare
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Dru
g R
elea
sed
(n
g)
Micro-Robot Actuation
Actuation Mechanisms• Diffusion - Bare Robots
- Drug Limited by Area
• Magnetic Modulation
- Magnetic Interference
• Ultrasound
- Drug Encapsulation
Drug Release vs. Time
IRIS - ETH Zurich
Dru
g R
elea
sed
(n
g)
Time (min.)
Actuation
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Discoveries and Conclusion
~ Thank you for your Attention ~~ Thank you for your Attention ~
The University of ArizonaAdvanced Micro and Nano Systems Laboratory
Dept. of Aerospace and Mechanical Engineering
Ultrasound has been confirmed as a successful alternative Release mechanism for encapsulated micro-robots while presenting new Capabilities for controlled drug release.
The utilization of a dual-phase extrusion system allows increased uniformity and controlled variability of the encapsulation process.
By Encapsulating micro-Robots we can increase in the drug capacity and storage capabilities of the Micro-robot.
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Acknowledgement and Thanks
Acknowledgement and Thanks toDr. Eniko T. Enikov
Principal Investigator and Mentor
Advanced Micro and Nano-Systems laboratory GroupFor their help and guidance
UA/NASA Space Grant ProgramFor their support and research Encouragement
ASU/NASA Space Grant ProgramFor Organizing and Hosting the Statewide Symposium
The Institute of Robotics and Intelligent Systems (IRIS)ETH Zurich - Switzerland
The University of ArizonaAdvanced Micro and Nano Systems Laboratory
Dept. of Aerospace and Mechanical Engineering