nov2004 natural products expo asia 2005 hong kong astaxanthin: a radical approach to vitality &...

NOV2004

Natural Products Expo Asia 2005 Hong Kong

Astaxanthin:Astaxanthin: A Radical Approach to A Radical Approach to Vitality & Beauty From Vitality & Beauty From WithinWithin

Natural Products Expo Asia 2005

Vincent Wood PhD, Manager

International Business Dept/Marketing

NOV2004


• What is Astaxanthin?What is Astaxanthin?• Why is it so potent compared to other carotenoid Why is it so potent compared to other carotenoid

antioxidants?antioxidants?• The Research & Impact on HealthThe Research & Impact on Health• Summary of Recent AdvancesSummary of Recent Advances

– Supplement use in Muscle Endurance, Eye health and Cosmetic benefitSupplement use in Muscle Endurance, Eye health and Cosmetic benefit

• Retail Examples in JapanRetail Examples in Japan• Regulatory, Production Technology & SupplyRegulatory, Production Technology & Supply

T O D A Y ’ S P R E S E N T A T I O N O U T L I N E

NOV2004


• 600 known carotenoids*600 known carotenoids*• Humans cannot synthesise Humans cannot synthesise

carotenoids.carotenoids.• Need to obtain carotenoids Need to obtain carotenoids

from food.from food.• <25 obtained from food.<25 obtained from food.• Basic carotene structureBasic carotene structure• Xanthophyll ClassXanthophyll Class

– LuteinLutein– AstaxanthinAstaxanthin

Molecular Formula: Molecular Formula: CC4040HH5252OO44

Molecular Weight:Molecular Weight: 596.82596.82CAS No: CAS No: 472-61-7472-61-7

O

HO

O

OH

*Parker RS.,1997

A M E M B E R O F T H E C A R O T E N O I D F A M I L Y

AstaxanthinAstaxanthin

LuteinLutein

-Carotene-CaroteneOH

OH

NOV2004


1938 1938 Lobster Lobster (Astacus gammarus) Discovered(Astacus gammarus) Discoveredby Nobel Laureate Dr Kuhnby Nobel Laureate Dr Kuhn

Present Day Present Day Other SourcesOther SourcesMicroalgae Microalgae (Haematococcus pluvialis)(Haematococcus pluvialis)Yeast Yeast (Phaffia rhodozyma)(Phaffia rhodozyma)BacteriaBacteria (Agrobacterium aurantiacum)(Agrobacterium aurantiacum)Higher PlantsHigher Plants (Adonis aestivalis)(Adonis aestivalis)Crustaceans Crustaceans ((Euphasia supurbaEuphasia supurba))Fish Fish (Salmon) Typically 1mg per 200g(Salmon) Typically 1mg per 200gBirds Birds (Flamingo, Cockerel)(Flamingo, Cockerel)

A S T A X A N T H I N B A C K G R O U N D

NOV2004


Haematococcus pluvialisHaematococcus pluvialis

AstaxanthinAstaxanthinPowerful Antioxidant Powerful Antioxidant DDefenefencce Against Free Radicalse Against Free RadicalsPProtects Plant Cell Contentsrotects Plant Cell Contents

HaematoHaemato (Blood) (Blood) coccuscoccus (Seed) (Seed)

Microalgae family – includes Microalgae family – includes SpirulinaSpirulina

Harsh Environment – Dormant / HibernatesHarsh Environment – Dormant / Hibernates

““Astaxanthin efficiently functions as an Astaxanthin efficiently functions as an antioxidant agent in both cytoplasmic and antioxidant agent in both cytoplasmic and membraneous regions to protect cells in membraneous regions to protect cells in vivo against environmental oxidative vivo against environmental oxidative stress.”stress.”(1999 Kobayashi, M., Okada, T. Protective Role of Astaxanthin to (1999 Kobayashi, M., Okada, T. Protective Role of Astaxanthin to Protect Against UVB Radiation in the Green Alga Haematococcus Protect Against UVB Radiation in the Green Alga Haematococcus pluvialis.)pluvialis.)

Microalgae 15,000 ppm Yeast 8,000 ppm Krill 1,500 ppm.

NOV2004


A S T A X A N T H I N M E A N S M O R E H E N S F O R T H E R O O S T E R !

COME HERE COME HERE GIRLS!GIRLS!

NOV2004


A S T A X A N T H I N & C A R O T E N O I D P E R C E P T I O N S

Low level of consumer and retail awareness

Too many antioxidants on Too many antioxidants on the marketthe market

Contradictory carotenoid evidence. Not enough science-carotene>lycopene>lutein>astaxanthin

A functional based product is A functional based product is being developed based on being developed based on microalgal astaxanthinmicroalgal astaxanthin

Natural vs Synthetic

Microalgae vs Yeast

Perceived to be expensive!

only small amounts are only small amounts are required. Can complements required. Can complements existing formulations existing formulations

Unstable supply in the past,

Intense competition

‘‘Wait and see” attitude on Wait and see” attitude on market developmentsmarket developments

“Frost & Sullivan estimates that astaxanthin is now one of the fastest growing carotenoids in Europe. European carotenoids were worth $348.5 million in 2003, with 17 per cent of this coming from supplements. But currently less than 1 ton of astaxanthin is going into supplements per year, compared to up to 150 tons for the aquaculture industry.” Source: Nutraingredients.com 22/03/04

NOV2004


Physical QuenchingPhysical Quenching 1O2 + 1Carotenoid → 3O2 + 3Carotenoid* 3Carotenoid* → 1Carotenoid + thermal energy*

↓

ASTAXANTHIN ELIMINATES FREE RADICALS EXTREMELY FAST BY ENERGY TRANSFER**

Chemical Reaction Chemical Reaction (e.g. (e.g. -Carotene)-Carotene)

1O2 + Carotenoid → Carotenoid RADICAL → OXIDIZED*B.R.Nielsen, K.Jorgensen and L.H.Skibsted : Triplet-triplet extinction coefficients, rate constants of triplet decay and rate constants of anthracene triplet sensitization by laser flash photolysis of astaxanthin, β-carotene, canthaxanthin and zeaxanthin in deaerated toluene at 298K, J.Photochem.Photobio.A:Chem., 112, 127-133 (1998).

A N T I O X I D A N T M E C H A N I S M S

“The energy of the singlet state oxygen is quickly transferred to the carotenoid by direct contact, and the carotenoid in the triplet state relaxes to the singlet state very quickly by the transformation of the potential energy into thermal energy through the vibration of conjugated double bonds in the polyene chain.” (Miki, M., Biological Functions and Activities of Animal Carotenoids. Pure Appl. Chem. 63. 141-146. 1991.)

NOV2004


0

500

1000

1500

2000

2500

3000

3500

Astaxanthin Zeaxanthin Cantaxanthin Lutein ß-Carotene Vitamin E

Antioxidant

ED

50 v

alu

e (nM

)

Scavenging: Carotenoids with oxygen groups most efficient against lipid peroxidation.

Astaxanthin was the most efficient scavenger. Miki, W. Pure & Appl. Chem. 63(1);141-46

S C A V E N G I N G E F F E C T O F D I F F E R E N T A N T I O X I D A N T S I N A L I P O P H I L L I C

I N V I T R O M O D E L

NOV2004


　　　　　　 e －　　　　　e －

　　　　　　　３ O2 　→　・ O2－　→　 H2O2 　 → ・ OH 　　 O ２　 LH

１ O2 LH 　→　 L ・　→　 LOO ・　→　 LOOH

　　　　　　　　　　　　　　　　　　　 H2O 　　　　　　　　 L ・　　　

SODCatalase Ascorbic Acid

Astaxan

thin

　　　　↓　　　　　　　　　　　　　　 ↓　 ↓　　 ↓

　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　 ↓　　　　 ↓

QUENCHINGQUENCHING550 x550 x Vitamin E* Vitamin E*40 x 40 x -carotene*-carotene*

INHIBITSINHIBITSPEROXIDATIONPEROXIDATION

1000 x Vitamin E**1000 x Vitamin E**

N E U T RA L I Z I N G R O S

(Superoxide radical)

(Singlet oxygen radical)

(Hydroxy radicals)

(Peroxide radicals)

*N.Shimizu et al.: Carotenoids as singlet oxygen quenchers in marine organisms, Fisheries Science, 62, 134-137 (1996).

**Miki, W. Pure & Appl. Chem. 63(1);141-46. (ROS: Reactive Oxygen Species)

Astaxanthin

Vitamin E(tocopherol)

NOV2004


0 1 2 3 4

Astaxanthin

Zeaxanthin

Lycopene

β-Carotene

Normalized relative oxidation rates

H.D.Martin, et al. : Chemistry of carotenoid oxidation and free radical reactions,

Pure Appl. Chem., 71(12), 2253-2262 (1999).

Pure Pure Anti-oxidantAnti-oxidant

Anti- andAnti- andPro-oxidantsPro-oxidants

A S T A X A N T H I N - I S T H E P U R E A N T I O X I D A N T

NOV2004


T H E A S T A X A N T H I N S H I E L D

Lignell A., & Wood V., Astaxanthin: Radical Cellular Defense. May 2004 Innovations in Food Technology.

NOV2004


A S T A X A N T H I N D I S T R I B U T I O N I N R A T S A F T E R 3 W E E K S O N S U P P L E M E N T E D D I E T

( 1 0 0 m g A x / k g f e e d ).

0

10

20

30

40

50

60

70

80

Blood Brain Heart Kidney Liver Lung Muscle Skin

Organ

µg a

stax

anth

in/k

g

A S T A X A N T H I N S H I E L DA S T A X A N T H I N S H I E L D

US Pat 6,245,818 Medicament for improvement of duration of muscle function or treatment of muscle disorders or diseases.

NOV2004


P R O P E R T I E S O F A S T A X A N T H I N

Antioxidant Potency

Powerful Powerful singlet oxygensinglet oxygen quenching quenching and and free radicalfree radical scavenging activity. scavenging activity.

Protects against Protects against lipoperoxidationlipoperoxidation..

Solubility

Spans the membrane bi-lipid layer – Spans the membrane bi-lipid layer – comprehensive protection and comprehensive protection and strengthens rigiditystrengthens rigidity

Protection Forms a Forms a protective shieldprotective shield and and defends against continuous free defends against continuous free radical attack at the cellular level.radical attack at the cellular level.

Safety Defined as a Defined as a pure antioxidantpure antioxidant unlike unlike other well known antioxidants that can other well known antioxidants that can become become pro-oxidantspro-oxidants..

NOV2004


C A T E R G O R I Z E D L I T E R A T U R E

C A T E R G O R Y P U B L I C A T I O N SGeneral NutritionGeneral Nutrition

Stomach & Gut Health*Stomach & Gut Health*

Eye Health**Eye Health**

Sports Nutrition*Sports Nutrition*

Vetinary Health*Vetinary Health*

CosmecuticalsCosmecuticals

Antioxidant potency, Synergies.Antioxidant potency, Synergies.

Helicobacter, dyspepsiaHelicobacter, dyspepsia

Visual Fatigue, Diabetic CataractVisual Fatigue, Diabetic Cataract

Muscle Endurance and damage, Muscle Endurance and damage, Visual Acuity, anti-inflammatory. Visual Acuity, anti-inflammatory.

Fertility, muscle endurance, anti-Fertility, muscle endurance, anti-inflammatoryinflammatory

UVR damage, photoprotectant, UVR damage, photoprotectant,

anti-inflammatory. anti-inflammatory.

*Patent Protected **Patent Applied

NOV2004


• Sports nutrition & supplement– Major market potential. Continues positive growth.

• Strenuous physical activity generates free radicals– up to 12 times more than at rest

• Activation of the inflammation response– Important factor for post strenuous exercise & recovery

• Feel oxidative damage – Muscle pain, tiredness, need for recovery

NOV2004


Protocol40 young healthy male students, age 17 - 19, were included. Standardized exercise tests were carried out at baseline and after three and six months of supplementation with 4 mg astaxanthin per day or placebo.

Inclusion 4 mg astaxanthinRandomisation Placebo

Parameters measured:- Fitness- Strength / endurance- Strength / explosivity

3 months 3 months

Dietary supplementation with astaxanthin improves muscle endurance.

A randomised double blind placebo controlled study on healthy male subjects.

(In Press) Investigator Curt L. Malmsten, PhD, MD,

Räddningshälsan AB,

Sweden.

NOV2004


R E S U L T S : C H A N G E S I N S T R E N G T H / E N D U R A N C E

Baseline

30

35

40

45

50

55

60

65

70

75

80

1 2 3

No.

of k

nee

bend

ings

/per

son

Placebo

Astaxanthin

6 months3 monthsBaseline

p < 0.05

Significant increase of muscle endurance.

No difference in fittness.

No difference in muscle explosivity.

NOV2004


Astaxanthin may be effective for:

Endurance Levels (4 mg daily dose)

Maintains Antioxidant Protection Levels

Reduces Recovery Time to Training

2002 Sawaki K., et al., reported a 28.5%

(P<0.05%) reduction in lactic acid build up

after 1200m supplemented subjects.

On-going US and Swedish clinical trials.

Results Due 1st QTR 2005.Muscle endurance US Pat 6,245,818

C O N C L U S I O N S

NOV2004


Damage MarkersMuscle cell staining – Cell membrane damageCreatine kinase (CK) – Damaged muscle cells8-hydroxy-2’-deoxyguanosine (OHdG) – DNA damage

Myeloperoxidase (MPO) - Inflammation 　

Acclimatization

・ Control (N=8)・ Exercise Control (N=8)・ Exercise Supplemented (N=8)

Training Program

Exercise

Protocol

１ wk 3wk

Euthanized

24hr

Astaxanthin Limits Exercise-Induced Skeletal and Cardiac Muscle Damage in Mice

Aoi, W. et al. 2003, Antioxidants & Redox Signalling, 5:(1) 139-144.

NOV2004


M U S C L E C E L L M E M B R A N E

Gastrocnemius

Heart

CONTROL EXERCISE CONTROL EXERCISE + AX

CONTROL EXERCISE + AXEXERCISE CONTROL

NOV2004


R E S U LT S

Creatine Kinase in Plasma

0

500

1000

1500

2000

2500

3000

3500

Control Exercised Ax+Exercised

U/L

p<0.05 p<0.05

Inflammation in Gastrocnemius and Heart

0.00

0.50

1.00

1.50

2.00

2.50

3.00

Control Exercised Ax+Exercised Control Exercised Ax+Exercised

Gastrocnemius Heart

MP

O A

cti

vit

y (

mU

/mg

pro

tein

)

*P<0.05*P<0.05*P<0.05*P<0.05

Production of 8-OHdG (DNA Damage)

0.00

0.50

1.00

1.50

Control Exercised Ax+ Exercised Control Exercised Ax+Exercised

Gastrocnemius Heart

8-O

Hd

G/1

05 x

dG

p< 0.05 p< 0.05

Overall Reduction of DNA damage

Reduction of Inflammatory Response

Reduction of Muscle Cell Damage

New Research to Mechanism using Gene Chip Analysis - 2005

NOV2004


I N F L A M M A T O R Y R E S P O N S E – I N A C T I V A T I O N OF N F – K B

Lignell A., & Wood V., Astaxanthin: Radical Cellular Defense. May 2004 Innovations in Food Technology.

NOV2004


NOV2004


Visual Display Terminals (VDT) at work and leisure. Increased Risk of developing glaucoma for heavy

computer use combined with short sightedness*. Eye Disorders – Blurring, Occular & Visual Asthenopia,

Headache Visual Acuity, Accommodation, Critical flicker fusion, Depth

Perception, Pattern Evoked Potential Deteriorates on Daily Basis & Fatigue Accumulates Age Related Macular Degeneration** No Data on Astaxanthin on VDT Induced Visual Fatigue

*Source: BBC News 16 Nov 2004 Japanese research 10,000 Japanese workers: Computer link to eye disease.

**US Patent 5,527,533, Tso & Lam, “Method of Retarding and Ameliorating Central Nervous System and Eye Damage”

E Y E H E A L T H - F A T I G U E

NOV2004


Visual Acuity (Landolt Ring) 5m & 35 cm

Accommodation Amplitude = Ciliary Muscle Function

Critical Flicker Fusion (CFF) = Central Nervous System (CNS)

Pattern Evoked Potention (PEVP) = Visual Nerve connection the to brain

Patient Questionnaire (Subject monitoring devised by Ophthalmologists)

C L I N I C A L P A R A M E T E R S

*Nagaki Y., et al., 2002 Journal of Traditional Medicines 19(5):170-173.**Koide R., et al., 1994 Effects of Whortleberry extract on ocular function. J. Eye 11:117-121.***Sawaki K., et al., 2002. Sports Performance Benefits from Taking Natural Astaxanthin Characterized by Visual Acuity and Muscle Fatigue in Humans. J. Clin. Ther. Med. 18(9):73-88.****Nakamura A., et al., 2004. Changes in Visual Function Following Peroral Astaxanthin. 57th Congress of Clinical Opthalmology of Japan 58(6):1051-1054 (Japanese).

NOV2004


Questionnaire revealed a 54% reduction of eye strain symptoms* at 5 mg/day after 4 weeks (N=26) and better accomodation (P<0.01). Agree with Whortleberry** Hypofunction of Ciliary Body

6mg/day*** for 4 weeks (n=18) showed better depth perception and CFF (P<0..05)

Accomodation improved at 4 mg (P<0.05) and 12 mg/day (P<0.1) (n=49)****

FOSHU Planned Mid 2005 Agent for improving

accommodation blood flow in the eye. VDT Subjects w ith Eye Strain Symptoms before and after astaxanthin supplementation

0

2

4

6

8

10

12

14

Before After Before After

Group B (Treated) Group C (Placebo)

No

. o

f S

ub

jects

wit

h E

ye

Str

ain

E Y E F A T I G U E C O N C L U S I O N

*Nagaki Y., et al., 2002 Journal of Traditional Medicines 19(5):170-173.**Koide R., et al., 1994 Effects of Whortleberry extract on ocular function. J. Eye 11:117-121.***Sawaki K., et al., 2002. Sports Performance Benefits from Taking Natural Astaxanthin Characterized by Visual Acuity and Muscle Fatigue in Humans. J. Clin. Ther. Med. 18(9):73-88.****Nakamura A., et al., 2004. Changes in Visual Function Following Peroral Astaxanthin. 58(6):1051-1054 (Japanese).

NOV2004


Wrinkles - where do you have them?

Eyes>Forehead>Mouth

UNAVOIDABLE. It’s all part of the aging process.

Causes of aging can be partially counteracted.

By improving nutrition and minimizing phototic injury.

NOV2004


Astaxanthin

BEAUTY FROM WITHIN – The Next Hot Market SegmentL’Oreal & Nestle – “Innévo” 2002 Targeting women >40 y.o.***

Early studies in mice models revealed significant long terms protection against premature wrinkle formation caused by UVA and UVB exposure*

Topical application lowers the UVB induced inflammatory process that may lead to hyperpigmentation**

*Arakane K., 2002. Superior protection via astaxanthin. Carotenoid Science, Vol 5.

**Yamashita E., 1995. Suppression of Post UVB hyperpigmentation by Topical astaxanthin from krill. Fragrance Journal 14:180-185. ***Times, March 2004 (US) L’Oreal innovations - Beauty foods.

NOV2004


Cosmetic benefit of a Dietary Supplement Cosmetic benefit of a Dietary Supplement Containing Astaxanthin & TocotrienolContaining Astaxanthin & Tocotrienolon Human Skinon Human Skin

Yamashita, E. 2002, FOOD Style 21, 6:(6) 112-117.

A Randomized Double Blind Placebo Controlled Study

Supplemented group - Astaxanthin 2mg from Haematococcus pluvialis - Tocotrienol 40mg from palm fruit - Canola oilSubjects

- Healthy female with dry skin conditions

- n=8 (supplemented group) + 8 (placebo)

- Mean age: 40 years old

Methods

- 1 capsule per day in the evening for 4 weeks

- Parameters measured at start, 2 and 4 weeks

Parameters

- Standardized questionnaire

- Dermatologist inspection/palpation

- Skin moisture & sebum content

- Magnified skin surface inspection

NOV2004


NOV2004


• Skin condition by individual assessment

R E S U L T S 1R E S U L T S 1

4 Weeks

-1.0

0.0

1.0

2.0

3.0

Treated

Placebo2 Weeks

-1.0

0.0

1.0

2.0

3.0

Treated

Placebo

To

tal

Sag

Po

uc

h

Fin

e w

rin

kle

Wri

nkl

e

Red

nes

s

Sp

ots

/Fre

ckle

s

Du

lln

ess

Acn

e/P

imp

les

Co

mp

lexi

on

Ela

stic

ity

Oil

ines

s

Sm

oo

thn

ess

Mo

istu

re

To

tal

Sag

Po

uc

h

Fin

e w

rin

kle

Wri

nkl

e

Red

nes

s

Sp

ots

/Fre

ckle

s

Du

lln

ess

Acn

e/P

imp

les

Co

mp

lexi

on

Ela

stic

ity

Oil

ines

s

Sm

oo

thn

ess

Mo

istu

re

Ch

ang

es o

f sk

in c

on

dit

ion

(-w

ors

e/+

bet

ter)

Ch

ang

es o

f sk

in c

on

dit

ion

(-w

ors

e/+

bet

ter)

p<0.05 p<0.05

NOV2004


• Dermatologist inspection/palpation


-3

-2

-1

0

1

2

3

Traeted

PlaceboWeek 2

To

ug

hE

last

icit

y

Sm

oo

thn

ess

Sag

Po

uc

h

Fin

e w

rin

kle

Wri

nkl

e

Red

nes

s

Sp

ots

/Fre

ckle

sD

ull

nes

s

Acn

e/P

imp

les

Co

mp

lexi

on

Oil

ines

s

Ski

n t

ext

ure

Mo

istu

reP

ulp

free

Dar

k ri

ng

s ar

ou

nd

eye

s

Ski

n c

olo

r

-3

-2

-1

0

1

2

3

Treated

PlaceboWeek 4

Sm

oo

thn

ess

Sag

Po

uc

h

Fin

e w

rin

kle

Wri

nkl

e

Red

nes

s

Sp

ots

/Fre

ckle

sD

ull

nes

s

Acn

e/P

imp

les

Co

mp

lexi

on

Oil

ines

s

Ski

n t

ext

ure

Mo

istu

re

To

ug

h

Pu

lpfr

ee

Dar

k ri

ng

s ar

ou

nd

eye

s

Ski

n c

olo

r

Ela

stic

ity

p<0.05

p<0.01p<0.1

p<0.1p<0.1

Ch

ang

es o

f sk

in c

on

dit

ion

(-w

ors

e/+

bet

ter)

Ch

ang

es o

f sk

in c

on

dit

ion

(-w

ors

e/+

bet

ter)

NOV2004


• Skin moisture content

Eye Region

-20

-10

0

10

20

30

40

50

2 Weeks 4 WeeksVaria

tion

(mic

roS)

Treated

PlaceboCheek

-20

-15

-10

-5

0

5

10

15

2 Weeks 4 Weeks

Var

iation

(m

icro

S)

Treated

Placebo


p<0.05

NOV2004


• Skin sebum content

Brow

-12

-10

-8

-6

-4

-2

0

2

4

6

2 Weeks 4 Weeks

Var

iation

TreatedPlacebo Cheek

-12

-10

-8

-6

-4

-2

0

2

4

6

2 Weeks 4 Weeks

Var

iation

TreatedPlacebo


NOV2004


• Magnified skin surface inspection


M4

4 weeks2 weeksStart

NOV2004

Natural Products Expo Asia 2005 Hong KongPossible Mechanism of ActionPossible Mechanism of Action

- Visual Wrinkle Reduction -- Visual Wrinkle Reduction -

1O21O2

1O2

UV

A

UV

A

Singlet oxygen induced UVA oxidizes collagen→ WRINKLE



New CollagenNew CollagenThank you !!Thank you !!

TocotrienolTocotrienol

TocotrienolTocotrienol

NOV2004


• Increased moisture levelsIncreased moisture levels• Consistent natural oilsConsistent natural oils• Reduction of fine wrinkles and pimplesReduction of fine wrinkles and pimples• Improved elasticityImproved elasticity• Reduced swelling under the eyesReduced swelling under the eyes

Astaxanthin & Tocotrienol supplementation resulted in

C O N C L U S I O N C O N C L U S I O N

NOV2004


J A P A N E S E R E T A I L P R O D U C T S

Astaxanthin & Blueberry

Astaxanthin & Natto Kinase

Astaxanthin + Astaxanthin + Tocotrienol & SOD Tocotrienol & SOD 60 soft cap 60 soft cap

3,800 JPY/month3,800 JPY/month

37 USD or 287 HKD37 USD or 287 HKD

Pure Astaxanthin

Astaxanthin Astaxanthin 1mg/day + 1mg/day + DHA+ARADHA+ARA

6,300 JPY/month6,300 JPY/month


Astaxanthin 2mg/day+ pomegranate juice Astaxanthin 2mg/day+ pomegranate juice 500mL. 6,000 JPY/month, 58 USD or 453 HKD500mL. 6,000 JPY/month, 58 USD or 453 HKD

NOV2004


C O S M E C E U T I C A L S & B E A U T Y S U P P L E M E N T S

NatuReal Corp.NatuReal Corp.

Astaxanthin, Tocotrienol & Astaxanthin, Tocotrienol & CollagenCollagen

Supplement 7,000 JPY/monthSupplement 7,000 JPY/month

Cream 9000 JPY Cream 9000 JPY

Essence 10,000 JPY Essence 10,000 JPY

68-97 USD or 529-755 HKD68-97 USD or 529-755 HKD

J A P A N E S E R E T A I L P R O D U C T S

Shiseido: Pure White Shiseido: Pure White Astaxanthin 0.5 mg/day plus Astaxanthin 0.5 mg/day plus multivitamins. multivitamins.

Drink 250 JPY 250 mL/day, Drink 250 JPY 250 mL/day, 2.40 USD or 18.9 HKD2.40 USD or 18.9 HKD

Tablet 4000 JPY/ month,Tablet 4000 JPY/ month,


NOV2004


R E G U L A T O R Y I N F O R M A T I O N

US DSHEA granted for 2 mg/day – 4 DSHEA granted for 2 mg/day – 4 mg/day. mg/day.

No GRAS statusNo GRAS status

CFTA/INCI ListedCFTA/INCI Listed

Japan Listed under Food Additives & Listed under Food Additives & ColouringColouring

JP Cosmetic ListedJP Cosmetic Listed

Europe Only biomass approvedOnly biomass approved

EU approvals not yet harmonisedEU approvals not yet harmonised

Requires EU Novel Foods Requires EU Novel Foods Approval Approval

Country SpecificCountry Specific

China/Hong Kong Rquires “Bao Jian Shipin” or Rquires “Bao Jian Shipin” or Health Enchaning Foods approvalHealth Enchaning Foods approval

No information availableNo information available

NOV2004


I N T E R N A T I O N A L M A R K E T I N G S E C T I O NI N T E R N A T I O N A L M A R K E T I N G S E C T I O N

33rdrd F L R H A L I F A X O N A R I M O N B L D. F L R H A L I F A X O N A R I M O N B L D.

3 – 2 4 –1 0 N I S H I S H I N B A S H I 3 – 2 4 –1 0 N I S H I S H I N B A S H I

M I N A T O – K U M I N A T O – K U

T O K Y O 1 0 5 – 0 0 0 3 J A P A NT O K Y O 1 0 5 – 0 0 0 3 J A P A N

( T ) + 8 1 – 3 – 3 4 3 7 – 2 3 5 3 ( T ) + 8 1 – 3 – 3 4 3 7 – 2 3 5 3

( F ) + 8 1 – 3 – 3 4 3 7 – 2 3 4 7( F ) + 8 1 – 3 – 3 4 3 7 – 2 3 4 7

w w w . f u j i c h e m i c a l . c o . j p / e n g l i s hw w w . f u j i c h e m i c a l . c o . j p / e n g l i s h

E m a i l : i n f o @ f u j i c h e m i c a l . c o . j pE m a i l : i n f o @ f u j i c h e m i c a l . c o . j p

C O N T A C T

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