Vol. 268, No. 34 The Journal of Biological Chemistry

Copyright 0 1993 by the American Society for Biochemistry and Molecular Biology, Inc. 428 East Preston St., Baltimore, MD 21202 U.S.A.

December 5,1993

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CONTENTS*

MINIREVIEW Yeast DNA replication. Judith L. Campbell

COMMUNICATIONS

brane by a COOH-terminal signal anchor sequence. Mai Targeting of Bcl-2 to the mitochondrial outer mem-

Nguyen, Dough G. Millar, V . Wee Yong, Stanley J. Kors- meyer, and Gordon C. Shore

Modified nucleotides of tRNAkY' modulate primerltem- plate loop-loop interaction in the initiation complex of HIV-1 reverse transcription. Catherine Isel, Roland Mar- quet, Gerard Keith, Chantal Ehresmnn, and Bernard Ehres- mann

Integrin u7 as substrate for a glycosylphosphatidyl- inositol-anchored ADP-ribosyltransferase on the sur- face of skeletal muscle cells. Anna Zolkiewska and Joel Moss

ARTICLES

cultures of rat hepatocytes. David A. Antonetti, Scot R. Regulation of rDNA transcription by insulin in primary

Kimball, Rick L. Horetsky, and Leonard S. Jefferson

Engineered topographic determinants with ab, flab, and BuBa topologies show high affinity binding to natlve protein antigen (lactate dehydrogenase-Cr). Susan Kobs-Conrad, Hyosil Lee, Ann M. DiGeorge, and Pravin T. P. Kaumaya

The interplay of the GrpE heat shock protein and Mga+ in RepA monomerization by DnaJ and DnaK. Dorota Skowyra and Sue Wickner

A novel ecto-phosphatidic acid phosphohydrolase activ- ity mediates activation of neutrophil superoxide gen- eration by exogenous phosphatidic acid. David K. Perry, Victoria L. Stevens, Theodore S. Widlanski, and J. David Lambeth

Differential acute-phase response of rat kininogen genes involves type I and type I1 interleukin-0 response elements. Huei-Mei Chen and Warren S. L. Liua

The adenine nucleotide translocase modulates oligo- mycin-induced quenching of pyranine fluorescence in submitochondrial particles. Mathias Ziegler and Harvey S. Penefsky

Activation of p21" by nerve growth factor in embry- onic sensory neurons and PC12 cells. Nancy F. L. Ng and Eric M. Shooter

Crystal structure of adenylosuccinate synthetase from Escherichia coli. Evidence for convergent evolution of GTP-binding domains. Bradley W. Poland, Mercedes M. Silva, Micheal A. Serra, Yunje C h , Kyung H. Kim, Erica M. S. Harris, and Richard B. Honzatko

Cyclic AMP stimulates efflux of intracellular sterol from cholesterol-loaded cells. Bj@rn M. Hokland, J. Peter Slotte, Edwin L. Bierman, and John F. Oram

Chemotactic methyltransferase promotes adaptation to repellents in Bacillus subtilis. Michael L. Kirsch, Aamir R. Zuberi, Dennis Henner, Pierette D. Peters, Mohammed A. Yazdi, and George W. Ordal

A Chinese hamster ovary cell line with a temperature- conditional defect in receptor recycling is pleiotropi- cally defective in lysosome biogenesis. Russell B. Wilson, Cynthia Corky Mastick, and Robert F. Murphy

25364 Molecular cloning and cDNA sequencing of endoxylo- glucan transferase, a novel class of glycosyltransferase that mediates molecular grafting between matrix polysaccharides in plant cell walls. Kazuhide Okazawa, Yoshiko Sato, Tomoko Nakagawa, Kiyozo Asada, Ikunoshin Kato, Etsuko Tomita, and Kazuhiko Nishitani

25369 Four contiguous amino acids define the target for strep- tolydigin resistance in the f l subunit of Escherichia coli RNA polymerase. Laura M. Heisler, Hideyuki Suzuki, Rob- ert Lundick, and Carol A. Gross

25376 Growth factor-inducible alternative splicing of non-

pre-mRNA. Victor I. Shifrin and Benjamin G. Nee1 transmembrane phosphotyrosine phosphatase PTP-1B

25385 Rapamycin-FKBP12 blocks proliferation, induces dif-

ogenic cell line. Thottala Jayaraman and Andrew R. Marks ferentiation, and inhibits cdc2 kinase activity in a my-

25389 Amino acid N-malonyltransferases from mung beans.

D-phenylalanine. Lining Guo, Allen T. Phillips, and Richard Action of 1-aminocyclopropane-1-carboxylic acid and

N. Arteca

25395 Species and subtype variants of the N-formyl peptide chemotactic receptor reveal multiple important func- tional domains. Ji-Liang Gao and Philip M. Murphy

25402 Characterization of the Streptococcus pneumoniae maltosaccharide regulator MalR, a member of the LacI- GalR family of repressors displaying distinctive genetic features. Antonio Puyet, A. Margarita Ibakz, and Manuel Espimsa

25409 Modifications in a flexible surface loop modulate the isozyme-specific properties of mammalian alkaline phosphatases. Massimn Bassi, Marc F. Hoylaerts, and Jose Luis Milldn

25417 PAM, a novel plasminogen-binding protein from S t r e p tococcus pyogenes. Andreas Berge and Ulf Sjobring

25425 Both the Escherichia coli chaperone systems, GroEL/ GroES and DnaK/DnaJ/GrpE, can reactivate heat- treated RNA polymerase. Different mechanisms for the same activity. Alicja Ziemienowicz, Dorota Skowyra, Jill Zeilstra-Ryalls, Olivier Fayet, Costa Georgopulos, and Maciej Zylicz

25432 pH-sensitive calcium release in triads from frog skele- tal muscle. Rapid filtration studies. Paulina Donoso and Cecilia Hidalgo

25439 Metabolism of leukotriene B, by cultured human ker- atinocytes. Formation of glutathione conjugates and dihydro metabolites. Pat Wheelan, Joseph A. Zirrolli, Jo- seph G. Morelli, and Robert C. Murphy

25449 I n vitro activity of the herpes simplex virus type 1 protease with peptide substrates. Carolyn L. Dilanni, Claudia Mapelli, Diana A. Drier, Jonglin Tsao, Sesha Natara- jan, Dough Rieringer, Stephen M. Festin, Mark Bolgar, Gre- gory Yamnaka, Steven P. Weinheimer, Chester A. Meyers, Richard J. Colonno, and Michael G. Cordingley

25455 Regulation of protein tyrosine phosphatases by insulin

David E. Hill, JerroM M. Olefsky, and Jyotirmoy Kusari and insulin-like growth factor I. Kathleen A. Kenner,

25463 Cloning of Chinese hamster DNA topoisomerase I cDNA and identification of a single point mutation responsible for camptothecin resistance. Akihiko Tani-

Jeffrey Jenkins, and Yves Pommier zawa, Richard Bertrand, Glenda Kohlhagen, Arata Tabuchi,

V

25469 Separate nuclear genes encode cytosolic and mitochon-

diecoideum. Heike Troll, T h o r n Winckler, Ioan h c u , Nor- drial nucleoside diphosphate kinase in Dictyostelium

bert Mdler, William Saurin, Michel Veron, and Rupert Mutzel

25476 Turnover of the photosystem I1 D l protein in higher plants under photoinhibitory and nonphotoinhibitory irradiance. Cecilia Sundby, Stephanie McCaffery, and Jan M. Anderson

25483 Substitutional and insertional RNA editing of the cy- tochrome c oxidase subunit 1 mRNA o! Physarum polycephalum. Jonatha M. Gott, Linda M. Vwomrrskr, and Joey L. Hunter

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Low density lipoprotein receptors bind and mediate cellular catabolism of normal very low density lipopro- teins in vitro. David A. ChuppeU, Glenna L. Fry, Michelle A. Waknrtz, LC& E. Muhonen, and Marc W. Plndet

Bovine lens aldose reductase. pH-dependence of steady- state kinetic parameters and nucleotide binding. Si-Qi Liu, Aruni Bhatnagar, and Satish K. Sriuastaua

responsible for the biosynthesis of choline plasmalogens Identification of a lyeophospholipase C that may be

by Madin-Darby canine kidney cells. Jay C. Strum and Larry W. Daniel

cycle with lgC-labeled lactate. Joseph Katz, Pat Wals, and Isotopomer studies of gluconeogenesis and the Krebs

W-N. Paul Lee

Appendix. Analysis of tricarboxylic acid cycle using mass isotopomer ratios. W-N. Paul Lee

Kinetics and regulation of three cloned mammalian Na+/H* exchangers stably expressed in a fibroblast cell line. Suaan A. Levine, Marshall H. Montrose, C. Ming Tse, and Mark Donowitz

Functional properties of the rat Na/H exchanger NHE- 2 isoform expressed in Na/H exchanger-deficient Chinese hameter ovary cells. Frank H. Yu, Gary E. ShuU, and John Orlowski

Comparison of kinetic properties between two mam- malian ma p21 GDP/GTP exchange proteins, rag gua- nine nucleotide-releasing factor and smg GDP dissocia- tion stimulator. Satoshi Orita, Kozo Kaibuchi, Shinya Ku- mda,. Kazuya Shimizu, Himyuki Nakanishi, and Yoshimi Taka1

25547 The inactivation of dihydroxy-acid dehydratase in Eecherichia coli treated with hyperbaric oxygen occurs because of the destruction of its Fe-S cluster, but the enzyme remains in the cell in a form that can be reac- tivated. Dennis H. Flint, Elizabeth Smyk-Randall, Joseph F. TumineUo, Bozena Draczynskn-Lusiak, and Olen R. Brown

25553 Tendon hypertrophy is associated with increased hy- droxylation of nonhelical lysine residues at two specific cross-linking sites in type I collagen. Joan E. Gerriets, Sandra L. Curwin, and Jerold A. Last

25561 Drosophila proteasome Dm26 subunit substitutes the

terminal domain is essential for subunit incorporation. mouse MC3 subunit in hybrid proteasomes. The N-

Angela Seelig, Gerd Multhaup, Brigitte Pesold-Hurt, Konrad Beyreuther, and Peter". Kloetzel

25568 Regulation of interleukin 8 gene expression by oxidant

John Kenmy, Laurence A. Boxer, and Daniel G. Remick stress. Laura E. DeForge, Angela M. Preston, Eiji Takeuchi,

25577 Molecular characterization of a multipromoter gene encoding a chicken filamin protein. Catherine P. Barry, Jinling Xie, Vance Lemmon, and Anthony P. Young

25587 RNA polymerase II transcription factor SIII. I. Identi- fication, purification, and properties. John N. Bradsher, Kenneth W. Jackson, Ronald C. Conuway, and Joan Weliky Conaway

25594 RNA polymerase I1 transcription factor SIII. 11. Func- tional properties and role in RNA chain elongation. John N. Bradsher, Siyuan Tan, Hei-Jen McLaury, Joan We- liky Conaway, and Ronald C. Conaway

25604 Nascent RNA cleavage by arrested RNA polymerase I1 does not require upstream translocation of the elonga-

Mote, Jr., and Daniel Reines tion complex on DNA. Weigang Gu, Wade Powell, John

25617 Retinoic acid posttranscriptionally up-regulates pro-

Mbnica Ldpez-Barahonu, Marta Miriano, Emilia Mira, Teresa teolipid protein gene expression in C6 glioma cells.

Juan Bernal. and Albert0 Murioz Iglesios, Hendrik G. Stunnenberg, Angeles Rodriguez-Peria,

25624 The role of NF-KB and NF-IL0 transactivating factors in the synergistic activation of human serum amyloid A gene expression by interleukin-1 and interleukin-0. Jonathan C. Betts, John K. Cheshire, Sh izw Akira, Tadimitzu Kishimoto, and Patrwia Woo

25632 Random mutagenesis of the sheep Na,K-ATPase. a-1 subunit generates a novel T797N mutation that results

M. Price in a ouabain-resistant enzyme. Edina L. Burns and Elmer

25636 Glucuronidation of hyodeoxycholic acid in human liver. Evidence for a selective role of UDP-glucuronosyl- transferase 2B4. Thierry PiUot, Mohamed Ou+ne, Sylvie Fournel-Gigleux, Chnntal aurie, Anna Radomcnskn, Braan Burchell, Gerard Siest, andyacques Magdalou

25643 Differential regulation of inducible and constitutive prostaglandin endoperoxide synthase in osteoblastic MC3T3-El cells. Carol C. Pilbeam, Hiroshi Kawaguchi, Yo-

Lawrence G. Raisz shiyuki Hakeda, Olga Voznesensky, Cynthia B. Alander, and

25650 Melanin biosynthesis patterns following hormonal

yashi, Katsuhiko Tsuknmoto, and Vincent J . Hearing stimulation. Pilar Aroca, Kazunori Urabe, Takeshi Koba-

25656 Demonstration that a kifunensine-resistant a-mannos- idase with a unique processing action on N-linked oli- gosaccharides occurs in rat liver endoplasmic reticulum and various cultured cells. Shuai Weng and Robert G. Spiro

25664 Membrane assembly of the outer membrane protein OmpA of Escherichia coli. Michael Klose, Anja Sthriko, York-Dieter Stierhof, Ingrid Hindennuch, Bettina Mutschler, and Ulf Henning

25671 Multiple signal transduction pathways induce phoe- phorylation of serines l0,26. and 38 of oncoprotein 18 in T lymphocytes. Ulrica Marklund, Ghran Brattsand, Orjan Osterman, Per-Inguar Ohlsson, and Martin GuUberg

25681 A rat homolog of the Drosophila enhancer of split (groucho) locus lacking WD-40 repeats. Carl J . Schmidt and Theresa E. Slodek

25687 Probing the active site of human aldose reductase. Site- directed mutagenesis of Asp-43, Tyr-48, Lys-77, and His-110. Iuan Tarle, David W . Borhani, David K. Wilson, Florante A. Quiocho, and J . Mark Petrash

25694 Incorporation of the pancreatic membrane protein GP-

cells. Timothy C. Hoops, Iuan Iuanou, Zheng Cui, Veronica 2 into secretory granules in exocrine but not endocrine

Colomer-Gould, and Mxhael J. Rindler

25706 The transactivation potential of variant hepatocyte nu- clear factor l is modified by alternative splicing. Fran- cois Ringeisen, Jauier Rey-Camps, and Moshe Yaniu

25712 I n vivo phosphorylation sites in fetal and adult rat tau. Atsushi Watanube, Masato Hasegawa, Masami Suzuki, Koji Takw, Maho Morishima-Kawashima, Koiti Titani, T a b Arai, Kenneth S. Kosik, and Yasw Ihara

25718 cDNA cloning, expression during development, and ge- nome mapping of PSY2, a second tomato gene encoding phytoene synthase. Glenn E. Bartley and Pablo A. Scolnik

428 East Preston Street, Baltimore, MD 21202, U S A . Volume 269 for 1994: Institutions: United States, $790; Foreign, $980. Students/Postdoctoral The Journal of Biological Chemistry (ISSN 0021-9258) is published weekly by the American Society for Biochemistry and Molecular Biology, Inc.,

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Binding affinity and inhibitory properties of a single-

David M. Kranz chain anti-T cell receptor antibody. Beth A. Schodin and

Tyrosine phosphorylation of Ras GTPase-activating

branes of v-Src transformed cells. Soochul Park and Rich- protein stabilizes its association with p62 at mem-

ard Jove

Human rhinovirus-14 protease 3C (3Cpm) binds specif- ically to the 6'-noncoding region of the viral RNA. Evidence that 3CPm has different domains for the RNA binding and proteolytic activities. Louis E. C. Leong, Philip A. Walker, and Alan G. Porter

Effect of monoclonal antibodies specific for the 28-kDa subunit on catalytic properties of the calpains. Jinyang Gong, Valery F. Thompson, and Darrel E. Go11

Mutations in two specific residues of testicular angio- tensin-converting enzyme change its catalytic proper- ties. Indira Sen, Sriram Kasturi, M. Abdul Jabbar, and Ganes C. Sen

Bile salt-dependent lipase biosynthesis in rat pan- creatic AR 4-2 J cells. Essential requirement of N- linked oligosaccharide for secretion and expression of

Bruneau, Abdelouahab Benajiba, and Dominique Lombard0 a fully active enzyme. Nezha Abouakil, Eric Mas, Nadine

Lysophosphatidylcholine reversibly arrests exocytosis

membrane merger. Steven S. Vogel, Eugenia A. Leikina, and viral fusion a t a stage between triggering and

and Leonid V . Chernomordik

The M. 36,000 &adrenergic receptor mRNA-binding

pentamer and U-rich domains for RNA recognition. protein induced by agonists requires both an AUUUA

Ling- Yan Hung , Baby G. Tholanikunnel, Evangelia Vakalop- oulou, and Craig C. Malbon

gen receptor fail to associate with Ig-a and Ig-@/r. Signaling-defective mutants of the B lymphocyte anti-

Stephan A. Grupp, Kerry Campbell, Richard N. Mitchell, John C. Cambier, and Abul K. Abbas

side diphosphate kinase activity, correlates with A serine phosphorylation of Nm23, and not its nucleo-

suppression of tumor metastatic potential. Nicholas J . MacDonald, Abel De La Rosa, Mary A. Benedict, Jose M. P. Freije, Henry Krutsch, and Patricur S. Steeg

Specific interaction of SPARC with endothelial cells is mediated through a carboxyl-terminal sequence con- taining a calcium-binding EF hand. Jeffrey C. Yost and E. Helene Sage

Binding of the 0-antigen of ShigeUa dysenteriae type 1 and 26 related synthetic fragments to a monoclonal IgM antibody. Viliam Pavliak, Eugenia,M. Nashed, Vince Pozsgay, Pavol KovciE, Arthur Karpas, Chrayung Chu, Rachel Schneerson, John B. Robbins, and Cornelis P. J. Glaudemans

articular chondrocytes and synovial cells, is a mam- Human cartilage gp-39, a major secretory product of

Hakala, Chantal White, and Anneliese D. Recklies malian member of a chitinase protein family. Brian E.

Mutation of histidine 373 to leucine in cytochrome

Monno, Hirofumi Ogawa, Takayasu Date, Motoji Fujioka, Wal- P460c17 c a u w 17a-hydroxylase deficiency. Satoshi

ter L. Miller, and Masashi Kobayasht

Unidirectional cross-phosphorylation between the granulocyte colony-stimulating factor and interleukin 3 receptors. Cai-Xi Pan, Rikiro Fukunaga, Shin Yonehara, and Shigekazu Nagata Possible role of both the a and By subunits of the het- erotrimeric G protein, G., in transcytosis of the poly- meric immunoglobulin receptor. Morgane Bomsel and Keith E. Mostou

Acetyl-coA carboxylase regulation of fatty acid oxi- dation in the heart. Maruf Saddik, James Gamble, Lee A. Witters, and Gary D. Lopaschuk

through the blockade of phosphatidylinositol 3-kinase Inhibition of histamine secretion by wortmannin

in RBL-2H3 cells. Hiroshi Yano, Satoshi Nakunishi, Kou- tarou Kimura, Nobw Hanui, Yutaka Saitoh, Yasuhisa Fukui, Yoshiaki Nonomura, and Yuzuru Matsuda Purification and characterization of UDP-N-acetylga- lactosamine Gnrs/Gns N-acetylgalactosaminyltransfer-

Kentaro Iwasaki, and Akemi Suzuki ase from mouse liver. Yasuhiro Hashimoto, Michiko Sekine,

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Expression and function of the cytoplasmic variants of

Activation-dependent adhesion and interaction with the integrin a6 subunit in transfected K682 cells.

isoforms of laminin. Gepke 0. Delwel, Frans Hogervorst, Ingrid Kuikman, Mats Paulsson, Rupert Timpl, and Arnoud Sonnenberg

The x-ray structure of Synechococcue ribulose-bis- phosphate carboxyl /oxygenase-activated quarter- nary complex a t 2 . 2 3 resolution. Janet Newman and Steven Gutteridge

Inositol 1.4,S-trisphosphate-mediated quantal Caa+ re-

within organelles. Alison D. Short, Michael G. Klein, Martin lease measured by high resolution imaging of Ca2+

F. Schneider, and Donald L. Gill

Loss of a neutralizing epitope by a spontaneous point mutation in the V3 loop of HIV-1 isolated from an infected laboratory worker. Fuluia di Marzo Veronese, Marvin S. Reitz, Jr., Goutam Gupta, Marjorie Robert-Guroff,

Paolo Lusso Cynthia Boyer-Thompson, Audrey Louie, Robert C. Gallo, and

Alteration of splice site selection by an exon mutation

Marion Reid, Geoff Daniels, and Olga 0. Blumenfeld in the human glycophorin A gene. Cheng-Han H u n g ,

Fe . bleomycin cleaves a transfer RNA precursor and its "transfer DNA" analog at the same major site. Chris E. Holmes and Sidney M. Hecht

Plurality of protein conformations of ribulose-1,S-bis-

high pressure electrophoresis. Leonard0 Erijman, Alejan- phosphate carboxylase/oxygenase monomers probed by

dm A. Palodini, George H. Lorimer, and Gregorw Weber

Crystal structures of oxidized and reduced Azotobacter vinelandii ferredoxin at pH 8 and 6. C. David Stout

Azotobacter vinelandii ferredoxin I. Aspartate 16 fa- cilitates proton transfer to the reduced [3Fe-4S] clus-

A. Armstrong, C. David Stout, Gerard M. Jensen, Philip J . ter. Binghui Shen, Lisandra L. Martin, Julea N. Butt, Fraser

Stephens, Gerd N . La Mar, Carol M. Gorst, and Barbara K. Burgess

Rapid degradation of an unassembled immunoglobulin light chain is mediated by a serine protease and occurs in a pre-Golgi compartment. Anne M. Gardner, Sigal Aviel, and Yair Argon

Cleavage at site A, Glu-642 to Ser-843, of the gizzard myosin heavy chain decreases affinity for actin. Mitsw Ikebe, Srabani Mitra, and David J . Hartshorne

ap and Br subunits. Sang Bong Lee, Seok Hwan Shin, John Activation of phospholipase C-82 mutants by G protein

R. Hepler, Alfred G. Gilman, and Sue Goo Rhee

p32 to the inner membrane of yeast mitochondria. Klaus Targeting and translocation of the phosphate carrier/

Dietmeier, Vincent0 Zara, Annamaria Palmisam, Ferdinand0 Palmieri, Wolfgang Voos, Jens Schlossmann, Martin Moczko, Gyula Kispal, and Nikolaus Pfanner

Hysteresis in the triple helix-coil transition of type I11 collagen. Janice M. Davis and Hans Peter Biichinger

On the role of the platelet membrane skeleton in medi- ating signal transduction. Association of GP IIb-IIIa, pp60"", p~62*~", and the p21- GTPase-activating protein with the membrane skeleton. Joan E. E. Fox, Lorraine Lipfert, Edwin A. Clark, Clifford C. Reynolds, Gary D. Austin, and Joan S. Brugge

Involvement of mitochondrial contact sites in the sub- cellular compartmentalization of phospholipid biosyn- thetic enzymes. Dominique Ardail, Franfoise Gasnier, Fabienne Lermi, Cedric Simonot, Pierre Louisot, and Odile Gateau-Roesch

Quantitative analysis of alternative splicing options of human plasma membrane calcium pump genes. Thomas P. Stauffer, Helene Hilfiker, Ernest0 Carafoli, and Emanuel E. Strehler

A new paradigm for biochemical energy coupling. Sal- monella typhirnuriurn nicotinate phosphoribosyltrans- ferase. Alexander Vinitsky and Charles Grubmeyer

Identification of G, as one of the G-proteins which copurify with human platelet thromboxane Adprosta- glandin Hz receptors. k ina Knezevic, Catherine Borg, and Guy C. Le Breton

vii

26018 Structural and functional characterization of the HPVl6 E7 protein expressed in bacteria. Gregory Pahel, Ann Alllabaugh, Steven A. Short, Julie A. Barnes, George R. Painter, Paul Ray, and William C. Phelps

26026 Goniodomin A induces modulation of actomyosin ATP- ase activity mediated through conformational change of actin. Ken-Ichi Furukawq Katunaga Sakai, Satoshi Wa- tanabe, Koscak Maruyamq Masahim Murakarni, Katsurni Ya- moguchi, and Yasushi Ohizumi

ADDITIONS AND CORRECTIONS 26032 Four conserved cysteine residues are required for the

DNA binding activity of nuclear factor I. Vol. 267

Richard M. Gmnostajski (1992) 12986-12990. Anton Nouak, Neerja mal, and

26032 Estradiol increases and anti-estrogens antagonize the

MCF7 breast cancer cells without affecting c-foe and growth factor-induced activator protein- 1 activity in

andre Philips, Dany Cholbos, and Henri Rochefort 3-jun synthesis. Vol. 268 (1993) 14103-14108. Alex-

26032 Effects of competitive sodium-like antagonists on Na,K-ATPase suggest that cation occlusion from the cytoplasmic surface occurs in two steps. Vol. 268 (1993) 16.929-16937. Eran Or, Peer David, Alh Shain- skaya, Danrel M. Tal, and Steven J. D. Karlish

26032 Sequencing and cloning of human prolylcarboxypepti-

boxypeptidase and prolylendopeptidase families. Vol. dase (angiotensinase C). Similarity to both serine car-

Randal A. Skidgel, and Ervin G. Erdos 268 (1993) 16631-16638. Fulong Tan, Paul W. Morris,

GENERAL INFORMATION

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Vol. 268, No. 34 The Journal of Biological Chemistry December 5, 1 993

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CONTENTS Arrange

MINIREVIEW Yeast DNA replication. Judith L. Campbell

CARBOHYDRATES, LIPIDS, AND OTHER NATURAL PRODUCTS

Identification of a lysophospholipase C that may be responsible for the biosynthesis of choline plasmalogens by Madin-Darby canine kidney cells. Jay C. Strum and Larry W. Daniel

Demonstration that a kifunensine-resistant a-mannos- idase with a unique processing action on N-linked oli- gosaccharides occurs in rat liver endoplasmic reticulum and various cultured cells. Shuai Weng and Robert G. Spiro

Binding of the 0-antigen of Shigella dyaenteriae type 1 and 26 related synthetic fragments to a monoclonal IgM antibody. Viliam Pavliak, Eugenia M. Noshed, Vince Pozsgay, Pavol Kov&, Arthur Karpas, Chiayung Chu, Rachel Schneerson, John B. Robbins, and Cornelis P. J. Glaudemans

Purification and characterization of UDP-N-acetylga- lactosamine Gnrs/Gos N-acetylgalactosaminyltransfer-

Kentaro Iwasaki, and Akemi Suzuki ase from mouse liver. Yasuhiro Hashimoto, Michikn Sekine,

CELL BIOLOGY AND METABOLISM

Targeting of Bcl-2 to the mitochondrial outer mem-

Nguyen, Douglas G. Millnr, V. Wee Yong, Stanley J . Kors- brane by a COOH-terminaI signal anchor sequence. Mai

meyer, and Gordon C. Shore

Integrin a7 as substrate for a glycosylphosphatidyl-

face of skeletal muscle cells. Anna Zolkiewsh and Joel inositol-anchored ADP-ribosyltransferase on the sur-

Moss

A novel ecto-phosphatidic acid phosphohydrolase activ-

eration by exogenous phosphatidic acid. David K. Perry, ity mediates activation of neutrophil superoxide gen-

Victoria L. Stevens, Theodore s. Widlanski, and J. David Lambeth

Activation of p21" by nerve growth factor in embry- onic sensory neurons and PC12 cells. Nancy F. L. Ng and Eric M. Shooter

Cyclic AMP stimulates efflux of intracellular sterol from cholesterol-loaded cells. Bj@n M. Hokland, J. Peter Slotte, Edwin L. Bierman, and John F. Oram

Chemotactic methyltransferase promotes adaptation to

Zuberi, Dennis Henner, Pierette D. Peters, Mohammed A. repellents in Bacillue subtilis. Michael L. Kirsch, Aamir R.

Yazdi, and George W. Ordal

A Chinese hamster ovary cell line with a temperature- conditional defect in receptor recycling is pleiotropi- cally defective in lysosome biogenesis. RusseU B. Wilson, Cynthia Corley Mastick, and Robert F. Murphy

Growth factor-inducible alternative splicing of non- transmembrane phosphotyrosine phosphatase PTP-1B pre-mRNA. Victor I . ShifTin and Benjamin G. Neel

Rapamycin-FKBPl2 blocks proliferation, induces dif- ferentiation, and inhibits cdc2 kinase activity in a my- ogenic cell line. Thottala Jayaraman and Andrew R. Marks

Metabolism of leukotriene B. by cultured human ker- atinocytes. Formation of glutathione conjugates and dihydro metabolites. Pat Wheelan, Joseph A. Zirrolli, Jo- seph G. Morelli, and Robert C. Murphy

Regulation of protein tyrosine phosphatases by insulin and insulin-like growth factor I. Kathleen A. Kenner, David E. Hill, JerroM M. Olefsky, and Jyotirmoy Kusari

!d by Subject Categories

25469 Separate nuclear genes encode cytosolic and mitochon- drial nucleoside diphosphate kinase in Dictyostelium diacoideum. Heike Troll, Thomas Winckler, Ioan h c u , Nor- bert Muller, William Saurin, Michel Vkron, and Rupert Mutzel

25487 Low density lipoprotein receptors bind and mediate cellular catabolism of normal very low density lipopro- teins in vitro. David A. Chappell, Glenna L. Fry, Michelle A. Waknitz, Linda E. Muhonen, and Marc W. Plodet

25509 Isotopomer studies of gluconeogenesis and the Krebs cycle with "C-labeled lactate. Joseph Katz, Pat Wals, and W-N. Paul Lee

25522 Appendix. Analysis of tricarboxylic acid cycle using mass isotopomer ratios. W-N. Paul Lee

25542 Comparison of kinetic properties between two mam-

nine nucleotide-releasing factor and amg GDP dissocia- malian raa p21 GDP/GTP exchange proteins, raa gua-

tion stimulator. Satoshi Orita, Kozo Kaibuchi, Shinya Ku- roda, Kazuya Shimizu, Hiroyuki Naknnishi, and Yoshimi Takni

25568 Regulation of interleukin 8 gene expression by oxidant stress. Laura E. DeForge, Angela M. Preston, Eiji Takeuchi, John Kenney, Laurence A. Boxer, and Daniel G. Remick

25643 Differential regulation of inducible and constitutive prostaglandin endoperoxide synthase in osteoblastic MC3T3-El cells. Carol C. Pilbeam, Hiroshi Kawaguchi, Yo- shiyuki Hakeda,, Olga Voznesensky, Cynthia B. Alander, and Lawrence G. Ralsz

25671 Multiple signal transduction pathways induce phos- phorylation of serines 16,26, and 38 of oncoprotein 18 in T lymphocytes. Ulrica Marklund, Goran Brattsand, Orjan Osterman, Per-Inguar Ohlsson, and Martin Gullberg

25694 Incorporation of the pancreatic membrane protein GP- 2 into secretory granules in exocrine but not endocrine cells. Timothy C. Hoops, Ivan Iuanov, Zheng Cui, Veronica Colomer-Gould, and Mzchael J. Rindler

25712 In vivo phosphorylation sites in fetal and adult rat tau., Atsushi Watanabe, Masato Hasegawa, Masami Suzuki, KOJZ Takio, Maho Morishima-Kawashima, Koiti Titani, Taka0 Arai, Kenneth S. Kosik, and Yasuo Ihara

25728 Tyrosine phosphorylation of Ras GTPase-activating protein stabilizes its association with p62 at mem- branes of v-Src transformed cells. Soochul Park and Rich- ard Jove

25764 Lysophosphatidylcholine reversibly arrests exocytosis and viral fusion at a stage between triggering, and membrane merger. Steven S. Vogel, Eugenia A. Letkzna, and Leonid V. Chernomordik

25769 The M. 36,000 @-adrenergic receptor mRNA-binding protein induced by agonists requires both an AUUUA pentamer and U-rich domains for RNA rEognition. Ling- Yan Huaq, Baby G. Tholanikunnel, Evangella Vakalop- oulou, and Crag C. Malbon

25776 Signaling-defective mutants of the B lymphocyte anti- gen receptor fail to associate with Ig-a and Ig-@/r. Stephan A . Grupp, Kerry Campbell, Richard N. Mitchell, John C. Cambzer, and Abul K. Abbas

25780 A serine phosphorylation of Nm23, and not its nucleo- side diphosphate kinase activity, correlates with suppression of tumor metastatic potential. Nicholas J. MacDonnld, Abel De La Rosa, Mary A. Benedict, Jose M. P. Freije, Henry Krutsch, and Patricia S. steeg

25790 Specific interaction of SPARC with endothelial cells is mediated through a carboxyl-terminal sequence con- taining a calcium-binding EF hand. Jeffrey C. Yost and E. Helene Sage

Indicates a Communication

viii

ix

25803

25818

25824

25836

25846

25865

25887

25940

25973

25985

26011

25364

25389

25409

25449

25494

Human cartilage gp-39. a major secretory product of articular chondrocytes and synovial cells, is a mam- malian member of a chitinase protein family. Brian E. Hakala, Chantal White, and Anneliese D. Recklies

Unidirectional cross-phosphorylation between the

3 receptors. Cui-Xi Pan, Rikiro Fukunaga, Shin Yonehara, granulocyte colony-stimulating factor and interleukin

and Shigekazu Nagata

Possible role of both the a and 87 subunits of the het- erotrimeric G protein, G., in transcytosis of the poly- meric immunoglobulin receptor. Morgane Borne1 and Keith E. Mostov

Acetyl-coA carboxylase regulation of fatty acid oxi- dation in the heart. Maruf Saddik, James Gamble, Lee A. Witters, and Gary D. Lopaschuk

Inhibition of histamine secretion by wortmannin through the blockade of phosphatidylinositol 3-kinase in RBL-2H3 cells. Hiroshi Yam, Satoshi Nakanishi, Kou- tarou Kimura, Nobuo Hanai, Yutaka Saitoh, Yasuhisa Fukui, Yoshiaki Nonomura, and Yuzuru Matsuda

Expression and function of the cytoplasmic variants of the integrin a6 subunit in transfected K662 cells. Activation-dependent adhesion and interaction with isoforms of laminin. Gepke 0. Delwel, Frans Hogeruorst, Ingrid Kuikman, Mats Paulsson, Rupert Timpl, and Armud Sonnenberg

Inositol 1,4,6-trisphosphate-mediated quantal Ca2+ re- lease measured by high resolution imaging of Ca2+ within organelles. Alison D. Short, Michael G. Klein, Martin F. Schneider, and Donald L. Gill

Rapid degradation of an unassembled immunoglobulin light chain is mediated by a serine protease and occurs in a pre-Golgi compartment. Anne M. Gardner, Sigal Avrel, and Yair Argon

On the role of the platelet membrane skeleton in medi- ating signal transduction. Association of GP IIb-IIIa, pp60Nm, p~62*~-, and the p21- GTPase-activating protein with the membrane skeleton. Joan E. B. Fox, Lorraine Lipfert, Edwin A. Clark, Clifford C. Reynolds, Cory D. Austin, and Joan S. Brugge

Involvement of mitochondrial contact sites in the sub- cellular compartmentalization of phospholipid biosyn- thetic enzymes. Do,minCue Ardail, Franqoise Gamier, Fabienne Lermi, Cedrtc Srmomt, Pwrre Louisot, and Odile Gateau-Roesch

copurify with human platelet thromboxane A2/prosta- Identification of G, as one of the G-proteins which

Guy C. Le Breton glandin Ha receptors. Irina Knezeuic, Catherine Borg, and

ENZYMOLOGY

Molecular cloning and cDNA sequencing of endoxylo- glucan transferase, a novel class of glycosyltransferase that mediates molecular grafting between matrix polysaccharides in plant cell walls. Kazuhide Okazawa,

Kato, Etsuko Tomita, and Kazuhiko Nishitani Yoshiko Sato, Tomoko Nakagawa, Kiyozo Asada, Ikunoshin

Amino acid N-malonyltransferases from mung beans.

D-phenylalanine. Lining Gw, Allen T. Phillips, and Richard Action of 1-aminocyclopropane-1-carboxylic acid and

N. Arteca

Modifications in a flexible surface loop modulate the

phosphatases. Massimo Bossi, Marc F. Hoylaerts, and Jose isozyme-specific properties of mammalian alkaline

Luis Milhin

I n vitro activity of the herpes simplex virus type 1 protease with peptide substrates. Carolyn L. Dilanni,

jan, Douglas Riexinger, Stephen M. Festin, Mark Bolgar, Gre- Claudio Mapelli, Diana A. Drier, Jonglin Tsao, Sesha Natara-

gory Yamanaka, Steven P. Weinheimer, Chester A. Meyers, Richard J . Colonno, and Michael G. Cordingky

Bovine lens aldose reductase. pH-dependence of steady-

Liu, Aruni Bhatnagar, and Satish K. Srivastava state kinetic parameters and nucleotide binding. Si-@

25547

25561

25636

25650

25687

25740

25748

25952

26004

26032

25320

25432

25476

25527

25536

25664

25958

The inactivation of dihydroxy-acid dehydratase in Escherichia coli treated with hyperbaric oxygen occurs because of the destruction of its Fe-S cluster, but the enzyme remains in the cell in a form that can be reac- tivated. Dennis H. Flint, Elizabeth, Smyk-Randall, Joseph F. Tuminello, Bozena Draczynska-Lusrok, and Olen R. Brown

Drosophila proteasome Dm26 subunit substitutes the mouse MC3 subunit in hybrid proteasomes. The N- terminal domain is essential for subunit incorporation. Angela Seelig, Gerd Multhaup, Brigitte Pesold-Hurt, Konrad Beyreuther, and Peter". Kloetzel

Glucuronidation of hyodeoxycholic acid in human liver. Evidence for a selective role of UDP-glucuronosyl-

Fournel-Giglew, Chantal Lafaurie, Anna Radomimka, Brian transferase 2B4. Thierry Pillot, Mohamed Ouzzine, Sylvie

Burchell, Gerard Siest, and Jacques Magdalou

Melanin biosynthesis patterns following hormonal

yashi, Katsuhiko Tsukamotoo, and Vincent J. Hearing stimulation. Pilar Aroca, Kazunori Urabe, Takeshi Koba-

Probing the active site of human aldose reductase. Site- directed mutagenesis of Asp-43, Tyr-48, Lys-77,,and His-110. Ivan Tarle, David W. Borhani, Davd K. Wtlson, Florante A. Quiocho, and J . Mark Petrash

subunit on catalytic properties of the calpains. Jinyang Effect of monoclonal antibodies specific for the 28-kDa

Cong, Valery F. Thompson, and Darrel E. Go11

Mutations in two specific residues of testicular angio- tensin-converting enzyme change its catalytic proper- ties. Indira Sen, Sriram Kasturi, M. Abdul Jabbar, and Ganes C. Sen

Activation of phospholipase C-82 mutants by G protein

R. Hepler, Alfred G. Grlman, and Sue Goo Rhee a, and Br subunits. Sang Bong Lee, Seok Hwan Shin, John

A new paradigm for biochemical energy coupling. Sal- monella typhirnuriurn nicotinate phosphoribosyltrans- ferase. Alexander Vinitsky and Charles Grubmeyer

Sequencing and cloning of human prolylcarboxypepti- dase (angiotensinase C). Similarity to both serine car- boxypeptidase and prolylendopeptidase families. Vol.

Randal A. Skidgel, and Ervin G. Erdos 268 (1993) 18631-16638. Fulong Tan, Paul W. Morris,

MEMBRANES AND BIOENERGETICS

The adenine nucleotide translocase modulates oligo- mycin-induced quenching of pyranine fluorescence in

Penefsky submitochondrial particles. Mathins Ziegkr and Harvey S.

pH-sensitive calcium release in triads from frog skele- tal muscle. Rapid filtration studies. Paulina Donoso and Cecilia Hidalgo

Turnover of the photosystem I1 D l protein in higher plants under photoinhibitory and nonphotoinhibitory irradiance. Cecilia Sundby, Stephanie McCaffery, and Jan M. Anderson

Kinetics and regulation of three cloned mammalian Na+/H+ exchangers stably expressed in a fibroblast cell line. Susan A. Levine, Marshall H. Montrose, C. Ming Tse, and Mark Donowitz

Functional properties of the rat Na/H exchanger NHE-

Chinese hamster ovary cells. Frank H. Yu, Gary E. Shull, 2 isoform expressed in Na/H exchanger-deficient

and John Orlowski

Membrane assembly of the outer membrane protein OmpA of Escherichia coli. Michael Klose, Anja Storiko,

and Ulf Henning York-Dieter Stwrhof, Ingrd Hindennach, Bettina Mutschler,

Targeting and translocation of the phosphate carrier/

Dietmeier, Vincenzo Zara, Annamaria Palmisano, Ferdinand0 p32 to the inner membrane of yeast mitochondria. Klaus

Palmieri, Wolfgang Voos, J e m Schlossmann, Martin Moczko, Gyula Kispal, and Ntkolaus Pfanner

X

26032 Effects of competitive sodium-like antagonists on Na,K-ATPase suggest that cation occlusion from the cytoplasmic surface occurs in two steps. Vol. 268 (1993) 16,929-16937. Eran Or, Peer David, Alln Shain- skaya, Dane1 M. Tal, and Steven J . D. Karlish

NUCLEIC ACIDS. PROTEIN SYNTHESIS. AND

925269

25277

25296

25311

25369

25395

25402

25463

25483

25577

25587

25594

25604

25617

25624

25681

25706

MOLECULAR GENETICS Modified nucleotides of tRNA? modulate primer/tem- plate loop-loop interaction in the initiation complex of HIV-1 reverse transcription. Catherine Isel, Roland Mar- quet, Ggrard Keith, Chantal Ehresmann, and Bernard Ehres- mann

cultures of rat hepatocytes. David A. Antonetti, Scot R. Regulation of rDNA transcription by insulin in primary

Kimball, Rick L. Horetsky, and Leonard S. Jefferson

The interplay of the GrpE heat shock protein and Mg2+ in RepA monomerization by DnaJ and DnaK. Dorota Skowyra and Sue Wickner

Differential acute-phase response of rat kininogen genes involves type I and type I1 interleukin-6 response elements. Huei-Mei Chen and Warren S. L. Lioo

tolydigin resistance in the subunit of Escherichia coli Four contiguous amino acids define the target for strep-

RNA polymerase. Laura M. Heisler, Hideyuki Suzuki, Rob- ert Landick, and Carol A. Gross

Species and subtype variants of the N-formyl peptide chemotactic receptor reveal multiple important func- tional domains. Ji-Liang Gao and Philip M. Murphy

Characterization of the Streptococcus pneumoniae

GalR family of repressors displaying distinctive genetic maltosaccharide regulator MalR, a member of the LacI-

features. Antonio Puyet, A. Margarita Ibakz, and Manuel Espinosa

cDNA and identification of a single point mutation Cloning of Chinese hamster DNA topoisomerase I

zawa, Richard Bertrand, Glenda Kohlhagen, Arata Tabuchi, responsible for camptothecin resistance. Akihiko Tani-

Jeffrey Jenkins, and Yves Pommier

tochrome c oxidase subunit 1 mRNA of Physarum Substitutional and insertional RNA editing of the cy-

polycephalum. Jonatha M. Gott, Linda M. Visomirski, and Joey L. Hunter

encoding a chicken filamin protein. Catherine P. Barry, Molecular characterization of a multipromoter gene

Jinling Xie. Vance Lemmon, and Anthony P. Young

RNA polymerase I1 transcription factor SIII. I. Identi- fication, purification, and properties. John N. Bradsher, Kenneth W . Jackson, Ronald C. Conaway, and Joan Weliky conaway

RNA polymerase I1 transcription factor SIII. 11. Func-

John N. Bradsher, Siyuan Tan, Hei-Jen McLaury, Joan We- tional properties and role in RNA chain elongation.

liky Conaway, and Ronald C. Conaway

Nascent RNA cleavage by arrested RNA polymerase I1 does not require upstream translocation of the elonga- tion complex on DNA. Weigang Gu, Wade Powell, John Mote, Jr., and Daniel Reines

Retinoic acid posttranscriptionally up-regulates pro- teolipid protein gene expression in C6 glioma cells. M6nica Ldpez-Barahona, Marta Miicano, Emilia Mira, Teresa

Juan Bernal, and Albert0 Murioz Iglesins, Hendrik G. Stunnenberg, Angeles Rodriguez-Pek,

The role of NF-nB and NF-IL6 transactivating factors in the synergistic activation of human serum amyloid

Jonathan C. Betts, John K. Cheshire, Shizuo Akrra, Tadimitzu A gene expression by interleukin-1 and interleukin-6.

Kishimoto, and Patricia Woo

A rat homolog of the Drosophila enhancer of split

and Theresa E. Sladek (groucho) locus lacking WD-40 repeats. Carl J. Schmidt

The transactivation potential of variant hepatocyte nu- clear factor l is modified by alternative splicing. Fran- cois Ringeisen, Javier Rey-Campos, and Moshe Yaniv

25718

25811

25902

25909

25993

26032

26032

25285

25334

25417

25425

25553

25632

25722

25735

25755

25876

cDNA cloning, expression during development, and ge-

phytoene synthase. Glenn E. Bartley and Pablo A. Scolnik nome mapping of PSY2, a second tomato gene encoding

Mutation of histidine 373 to leucine in cytochrome P450c17 causes 17a-hydroxylase deficiency. Satoshi Monno, Hirofumi Ogawa, Takayasu Date, Motoji Fujioka, Wal- ter L. Miller, and Masashi Kobayashi

Alteration of splice site selection by an exon mutation in the human glycophorin A gene. Cheng-Han Huung, Marion Reid, Geoff Daniels, and Olga 0. Blumenfeld

Fe . bleomycin cleaves a transfer RNA precursor and its

Holmes and Sidney M. Hecht "transfer DNA" analog at the same major site. Chris E.

Quantitative analysis of alternative splicing options of human plasma membrane calcium pump genes. T h o r n P. Stauffer, Helene Hilfiker, Ernest0 Carafoli, and Emanuel E. Strehler

Four conserved cysteine residues are required for the DNA binding activity of nuclear factor I. Vol. 267 (1992) 12986-12990. Anton Nouak, Neerja Goyal, and Richard M. Gronostapkr

Estradiol increases and anti-estrogens antagonize the growth factor-induced activator protein-1 activity in MCF7 breast cancer cells without affecting e-fos and 3-jun synthesis. Vol. 268 (1993) 14103-14108. Alex- andre Philips, Dany C h a h s , and Henri Rochefort

PROTEIN CHEMISTRY AND STRUCTURE Engineered topographic determinants with ab, BOB, and BaBa topologies show high affinity binding to native protein antigen (lactate dehydrogenase-C4). Susan Kobs-Conrad, Hyosil Lee, Ann M. DrGeorge, and Pravin T. P. Kaumuya

Escherichia coli. Evidence for convergent evolution of Crystal structure of adenylosuccinate synthetase from

GTP-binding domains. Bradley W. Poland, Mercedes M. Silva, Micheal A. Serra, Yunje Cho, Kyung H. Kim, Erica M. S. Harris, and Richard B. Honzatko

PAM, a novel plasminogen-binding protein from Strep- tococcus pyogenes. Andreas Berge and Ulf Sjobnng

Both the Escherichia coli chaperone systems, GroEL/

treated RNA polymerase. Different mechanisms for the GroES and DnaK/DnaJ/GrpE, can reactivate heat-

Zeilstra-Ryalls, Olivier Fayet, Costa Georgopoulos, and Maciej same activity. Alicja Ziemienowicz, Dorota Skowyra, Jill

Zylicz

Tendon hypertrophy is associated with increased hy- droxylation of nonhelical lysine residues at two specific cross-linking sites in type I collagen. Joan E. Gerriets, Sandra L. Curwin, and Jerold A. Last

Random mutagenesis of the sheep Na,K-ATPase a-1

in a ouabain-resistant enzyme. Edina L. Burns and Elmer subunit generates a novel T797N mutation that results

M. Price

Binding affinity and inhibitory properties of a single- chain anti-T cell receptor antibody. Beth A. Schodin and David M. Kranz

Human rhinovirus-14 protease 3C (3CDm) binds specif- ically to the 5'-noncoding region of the viral RNA. Evidence that 3CDr0 has different domains for the RNA binding and proteolytic activities. Louis E. C. Leong, Philip A. Walker, and Alnn G. Porter

Bile salt-dependent lipase biosynthesis in rat pan- creatic AR 4-2 J cells. Essential requirement of N- linked oligosaccharide for secretion ,and expression ,of

Bruneau, Abdelouuhub Benajiba, and Dominique Lombard0 a fully active enzyme. Nezhn Abouukrl, Errc Mas, Nadrne

phosphate carboxyl oxygenase-activated quarter- The x-ray structure of Synechococcus ribulose-bis-

nary complex at 2.!?fresolution. Janet Newman and Steven Gutteridge

Indicates a Communication

xi

25894 Lose of a neutralizinf epitope bf;a spontaneous point mutation in the V3 00 o HI -1 isolated from an

Marvin S. Reitz Jr., Goutam Gupta, Mar orce Robert-Guroff: infecFd laboratory warier. Fulvia di Marzo Veronese

Cynthia Boyer-hampson, Audrey Louie, hobert C. Gallo, and Paoh Lusso

25914 Plurality of protein conformations of ribulose-1 6-bis- Ehosphate carboxylase oxygenase monomers probed by

dm A. Palodini, George E. Lorimer, and Gregorio Weber igh pressure electro horesis. Leonardo Erijman Alejan-

25920 Crystal structures of oxidized and reduced Azotobacter vinelandii ferredoxin at pH 8 and 6. C. Davld Stout

25928 Azotobacter vinelandii ferredoxin I. As artate 16 fa- cilitates roton transfer to the reduced f3Fe-4SI clus-

A. Armstrong, C. Dauld Stout, Gerard M. Jensen Philip J . ter. Bingtui Shen, Lisandra L. Martin Julea N. Butt, Fraser

Stephens, Gerd N. La Mar, Carol M. Gorst, and Barbara K. Burgess

25948 Cleavage at site A. Glu-642 to Ser-643, of the gizzard myosin heavy chain decreases affinity for actin. Mitsuo Ikebe, Srabani Mitra, and David J . Hartshorne

25965 Hysteresis in the triple helix-coil transition of type I11 collagen. Janice M. Davis and Hans Peter Bkhinger

26018 Structural and functional characterization of the

Ann Aulnbaugh, Steven A. Short, Julie A. Barnes, George R. W V l 6 E7 protein expressed in bacteria. Gregory Pahel,

Painter, Paul Ray, and William C. Phelps

26026 Goniodomin A induces modulation of actomyosin ATP- ase activity mediated through conformational change of actin. Ken-Ichi Furukawa, Katunnga Sakai, Satoshi Wa- tanabe, Koscak Maruyamq Masahiro Murakami, Katsumi Ya- maguchi, and Yasushi Ohizumi

Abbas, Abul K., 25776 Abouakil, Nezha, 25755 Akira, Shizuo, 25624 Alander, Cynthia B., 25643 Anderson, Jan M., 25476 Antonetti, David A., 25277 Arai, Takao, 25712 Ardail, Dominique, 25985 Argon, Yair, 25940 Armstrong, Fraser A., 25928 Aroca, Pilar, 25650 Arteca, Richard N., 25389 Asada, Kiyozo, 25364 Aulabaugh, Ann, 26018 Austin, Cary D., 25973 Aviel, Sigal, 25940 Bachinger, Hans Peter, 25965 Barnes, Julie A,, 26018 Barry, Catherine P., 25577

Benajiba, Abdelouahab, Bartley, Glenn E., 25718

Benedict, Mary A., 25780 Berge, Andreas, 25417 Bernal, Juan, 25617 Bertrand, Richard, 25463 Betta, Jonathan C., 25624 Beyreuther, Konrad, 25561 Bhatnegar, Aruni, 25494 Bierman, Edwin L., 25343 Blumenfeld, Olga O., 25902

Bomsel, Morgane, 25824 Bolgar, Mark, 25449

Borg, Catherine, 26011 Borhani, David W., 25687 Bossi, Massimo, 25409 Boxer, Laurence A., 25568 Boyer-Thompson, Cynthia,

Bradsher, John N., 25587,

Brattsand, Goran, 25671 Brown, Olen R., 25547 Brugge, Joan S., 25973 Bruneau, Nadine, 25755

Burgess, Barbara K., 25928 Burchell, Brian, 25636

Burns, Edina L., 25632 Butt, Julea N., 25928 Cambier, John C., 25776 Campbell, Judith L., 25261

Carafoli, Ernesto, 25993 Campbell, Kerry, 25776

Chalbos, Dany, 26032 Chappell, David A., 25487 Chen, Huei-Mei, 25311 Chernomordik, Leonid V.,

25755

25894

25594

25764

Cheshire, John K., 25624 Cho, Yunje, 25334 Chu, Chiayung, 25797 Clark, Edwin A,, 25973 Colomer-Gould, Veronica,

25694 Colonno, Richard J., ,25449 Conaway, Joan Weliky,

25587.25594 Conaway, Ronald C., 25587,

Cong, Jinyang, 25740 Cordinaley, Michael G..

, ~~~~ ~

25594

25449 - .

Cui, Zheng, 25694 Curwin, Sandra L., 25553 Daniel, Larry W., 25500 Daniels, Geoff, 25902 Date, Takayasu, 25811 David, Peer, 26032 Davis, Janice M., 25965 DeForge, Laura E., 25568 De La Rosa, Abel, 25780 Delwel, Gepke 0.. 25865 Dietmeier, Klaus, 25958

DiIanni, Carolyn L., 25449 DiGeorge, Ann M., 25285

di Marzo Veronese, Fulvia,

Donoso, Paulina, 25432 Donowitz, Mark, 25527 Draczynska-Lusiak, Bozena,

Drier, Diana A,, 25449 Ehresmann, Bernard, 25269 Ehresmann, Chantal, 25269 Erdijs, Ervin G., 26032 Erijman, Leonardo, 25914 Espinosa, Manuel, 25402

Festin, Stephen M., 25449 Fayet, Olivier, 25425

Flint, Dennis H., 25547 Fournel-Gigleux, Sylvie,

Fox, Joan E. B., 25973 Freije, Jose M. P., 25780 Fry, Glenna L., 25487

Fukui, Yasuhisa, 25846 Fujioka, Motoji, 25811

Furukawa, Ken-Ichi, 26026 Fukunaga, Rikiro, 25818

Gallo, Robert C., 25894 Gamble, James, 25836 Gao, Ji-Liang, 25395 Gardner, Anne M., 25940 Gamier, Francoise, 25985 Gateau-Roesch, Odile, 25985

25894

25547

25636

AUTHOR INDEX

Georgopoulos, Costa, 25425 Gemets, Joan E., 25553 Gill, Donald L., 25887 Gilman, Alfred G., 25952 Glaudemans, Cornelis P. J.,

Goll, Darrel E., 25740

Gott, Jonatha M., 25483 Gorst, Carol M., 25928

Goyal, Neerja, 26032 Gronostajski, Richard M.,

Gross, Carol A,, 25369

Grupp, Stephan A,, 25776 Grubmeyer, Charles, 26004

Gu, Weigang, 25604 Gullberg, Martin, 25671 Guo, Lining, 25389 Gupta, Goutam, 25894 Gutteridge, Steven, 25876

Hakala, Brian E., 25803 Hakeda, Yoshiyuki, 25643 Hanai, Nobuo, 25846 Harris, Erica M. S., 25334 Hartshorne, David J., 25948 Hasegawa, Masato, 25712 Hashimoto, Yasuhiro, 25857 Hearing, Vincent J., 25650 Hecht, Sidney M., 25909

Henner, Dennis, 25350 Heisler, Laura M., 25369

Henning, Ulf, 25664 Hepler, John R., 25952

Hilfiker, Helene, 25993 Hidalgo, Cecilia, 25432

Hill, David E., 25455 Hindennach, Ingrid, 25664 Hogervorst, Frans, 25865 Hokland, Bjdrn M., 25343 Holmes, Chris E., 25909 Honzatko, Richard B., 25334 Hoops, Timothy C., 25694 Horetsky, Rick L., 25277 Hoylaerts, Marc F., 25409 Huang, ChengHan, 25902

Hunter, Joey L., 25483 Huang, LingYan, 25769

Iglesias, Teresa, 25617 IbGez, A. Margarita, 25402

Ihara, Yasuo, 25712 Ikebe, Mitsuo, 25948 Isel, Catherine, 25269 Ivanov, Ivan, 25694 Iwasaki, Kentaro, 25857

Jabbar, M. Abdul, 25748 Jackson, Kenneth W., 25587 Jayaraman, Thottala, 25385 Jefferson, Leonard S., 25277

25797

26032

Jenkins, Jeffrey, 25463 Jensen, Gerard M., 25928 Jove, Richard, 25728 Kaibuchi, Kozo, 25542 Karlish, Steven J. D., 26032 Kavas, Arthur, 25797 Kasturi, Sriram, 25748 Kato, Ikunoshin, 25364 Katz, Joseph, 25509 Kaumaya, Pravin T. P.,

Kawaguchi, Hiroshi, 25643 Keith, GBrard, 25269

Kenney, John, 25568 Kenner, Kathleen A., 25455

Kim, Kyung H., 25334 Kimball, Scot R., 25277 Kimura, Koutarou, 25846 Kirsch, Michael L., 25350 Kishimoto, Tadimitzu, 25624 Kispal, Gyula, 25958

Kloetzel, Peter"., 25561 Klein, Michael G., 25887

Klose, Michael, 25664 Knezevic, Irina, 26011 Kobayashi, Masashi, 25811 Kobayashi, Takeshi, 25650 Kobs-Conrad, Susan, 25285 Kohlhagen, Glenda, 25463 Korsmeyer, Stanley J., 25265 Kosik, Kenneth S., 25712 Kava;, Pavol, 25797 Kranz, David M., 25722

Kuikman, Ingrid, 25865 Krutsch, Henry, 25780

Kuroda, Shinya, 25542 Kusari, Jyotirmoy, 25455 Lafaurie, Chantal, 25636 La Mar, Gerd N., 25928 Lambeth, J. David, 25302 Landick, Robert, 25369

Last, Jerold A., 25553 Lascu, Ioan, 25469

Le Breton, Guy C., 26011 Lee, Hyosil, 25285 Lee, Sang Bong, 25952 Lee, W-N. Paul, 25509,25522

Lemmon, Vance, 25577 Leikina, Eugenia A., 25764

Leong, Louis E. C., 25735 Lerme, Fabienne, 25985 Levine, Susan A., 25527 Liao, Warren S. L., 25311

Liu, Si-Qi, 25494 Lipfert, Lorraine, 25973

Lombardo, Dominique, 25755 Lopaschuk, Gary D., 25836

25285

L6pez-Barahona, Mbnica,

Lorimer, George H., 25914 Louie, Audrey, 25894 Louisot, Pierre, 25985 Lusso, Paolo, 25894 MacDonald, Nicholas J.,

Magdalou, Jacques, 25636

Mapelli, Claudio, 25449 Malbon, Craig C., 25769

Marklund, Ulrica, 25671 Marks, Andrew R., 25385 Marquet, Roland, 25269 Martin, Lisandra L., 25928 Maruyama, Koscak, 26026 Mas, Eric, 25755 Mastick, Cynthia Corky,

Matsuda, YUZUN, 25846 McCaffery, Stephanie, 25476 McLaury, Hei-Jen, 25594 Meyers, Chester A,, 25449

Millar, Douglas G., 25265 Millin, J o d Luis, 25409

Miller, Walter L., 25811 Miiiano, Marta, 25617 Mira, Emilia, 25617 Mitchell, Richard N., 25776 Mitra, Srabani, 25948 Moczko, Martin, 25958 Monno, Satoshi, 25811 Montrose, Marshall H.,

Morelli, Joseph G., 25439 Morishima-Kawashima,

Morris, Paul W., 26032 Maho, 25712

Moss, Joel, 25273 Mostov, Keith E., 25824 Mote, John, Jr., 25604

Miiller, Norbert, 25469 Muhonen, Linda E., 25487

Multhaup, Gerd, 25561 Muiioz, Alberto, 25617 Murakami, Masahiro, 26026 Murphy, Philip M., 25395 Murphy, Robert C., 25439 Murphy, Robert F., 25357

Mutzel, Rupert, 25469 Mutschler, Bettina, 25664

Nagata, Shigekazu, 25818 Nakagawa, Tomoko, 25364 Nakanishi, Hiroyuki, 25542 Nakanishi, Satoshi, 25846 Nashed, Eugenia M., 25797 Natarajan, Sesha, 25449 Neel, Benjamin G., 25376

25617

25780

25357

25527