no slide title 24_chang neuro-ophthalmology.pdf · retinal emboli retinal infarcts 8 ... other...
TRANSCRIPT
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Neuro-Ophthalmology
Celia H. Chang MD
Department of Neurology
MIND Institute
University of California, Davis, Health System
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Lecture Content
Disorders of optic nerve and retina
Chiasmal and retrochiasmal disorders
Pupil disorders
Motility disorders
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Question #1
A 65-year-old woman has abrupt onset of visual loss in the right eye and weakness in the left arm and leg. There is some tingling of the left hand and left corner of her mouth. She is most likely to have a plaque in which blood vessel:
A. Anterior cerebral artery
B. Basilar artery
C. Internal carotid artery
D. Middle cerebral artery
E. Posterior cerebral artery
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Question #2
A 35 year old woman woke with double vision. She reports that it gets better if she covers one eye. On exam: when looking to the left, her left eye has nystagmus to the left and her right eye does not move past the midline. She is able to look right without difficulty. She has normal vertical eye movements and is able to converge. The rest of her neurologic exam is normal. The most likely diagnosis is:
A. Cavernous sinus thrombosis
B. Midbrain lacune
C. Multiple sclerosis
D. Myasthenia gravis
E. Thyroid ophthalmopathy
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Question #3
A 23 year old woman has the following visual field deficits.
Where is the lesion?
A. Optic radiation in the temporal lobe (Meyer's loop)
B. Optic nerve at the chiasm
C. Optic radiation in the parietal lobe
D. Lateral geniculate nucleus
E. Calcarine cortex of the occipital lobe
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Question #4
A 60 year old man is unable to report seeing a comb and a fork at the same time even when the 2 objects are held next to each other. He also has poor coordination of hand and eye movements, and difficult tracking objects visually. What is the most likely diagnosis:
A. Holmes-Adie syndrome
B. Balint syndrome
C. Gerstmann syndrome
D. Parinaud’s syndrome
E. Malingering
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Question #5
A 54 year old man has double vision. On exam, the left eye is deviated down and out. He also has ptosis and mydriasis. What is the most likely diagnosis:
A. Myasthenia gravis
B. Guillain-Barré syndrome
C. Posterior communicating artery aneurysm
D. Kearns-Sayre syndrome
E. Horner syndrome
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Disorders of Optic Nerve and
Retina
Drusen
Optic neuritis
Papilledema
Retinal emboli
Retinal infarcts
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dralbertlin.com/resources/_wsb_326x326_OpticNerveNml01.jpg
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www.google.com/imgres?imgurl=http://webeye.ophth.uiowa.edu/eyeforum/atlas/photos/OND2.jpg&imgrefurl=http://webe
ye.ophth.uiowa.edu10
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Optic Nerve Drusen
Refractile bodies
Frequently present at the nasal margin.
Visual field defects are common in patients
Afferent pupillary defect in asymmetric
cases
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www.eyes2health.com/images/optic%20neuritis.jpg
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www.uiowa.edu/~c064s01/nr122%20copy.jpg
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www.eyeweb.org/atlas/images/papilledema.jpg
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www.kellogg.umich.edu/theeyeshaveit/acquired/images/papilledema.jpg
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Pseudotumor Cerebri
Symptoms
Headache
Papilledema
Stabismus
Evaluate
Brain MRI with MRA and MRV
Lumbar puncture with opening pressure
Treatment16
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http://www.insightseyecare.net/EyeEducation/retinaNeuronalLayers.jpg18
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img.medscape.com/pi/emed/ckb/radiology/336139-417524-5003.jpg
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www.google.com/imgres?imgurl=http://www.kellogg.umich.edu
This refractile, yellow fleck is a platelet-
fibrin-cholesterol retinal embolus called a
Hollenhorst plaque20
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uuhsc.utah.edu/moraneyecenter/opatharch/images/retina/22030.jpg
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Chiasmal and Retrochiasmal
Disorders
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fc.units.it/ppb/neurobiol/Neuroscienze%20per%20tutti/vispath.gif
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www.jeffmann.net/NeuroGuidemaps/visualfields.gif
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www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=cm&part=A3543
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Autonomic Control of Pupils
Target Sympathetic Parasympathetic
Pupil dilator
muscle
Alpha 1 contracts
• Mydriasis
M 3 relaxes
• Miosis
Ciliary muscle Beta 2 relaxes
• Long range
focus
M 3 contracts
• Short range
focus
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Pupil Disorders
Afferent pupillary defect (APD)
Horner
Tonic
Third nerve palsy
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Marcus-Gunn Pupil or Afferent
Pupillary Defect
Optic neuritis
Ischemic optic neuropathies
Glaucoma
Traumatic optic neuropathy
Radiation optic nerve damage
Miscellaneous optic neuropathies, such as
Leber's optic neuropathy
Ischemic retinal disease 29
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Marcus-Gunn Pupil or Afferent
Pupillary Defect
Retinal detachmentif the macula or at
least two quadrants of retina
Severe macular degeneration
Not with cataract
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Argyll Robertson Pupil
Constrict when the patient focuses on a near
object (they “accommodate”)
Do NOT constrict when exposed to bright
light
Neurosyphilis
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www.ajnr.org/cgi/content/full/23/6/929/F1
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Horner’s Syndrome
Ptosis (superior tarsal muscle or Müller's muscle)
Miosis
Anhydrosis
Dilation lag
Enophthalmos
Iris hypopigmentation in congenital Horner’s due
to interference with melanin pigmentation
Lesion of cervical or thoracic sympathetic chain
Pancoast tumor (apical lung tumor)
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www.jeffmann.net/NeuroGuidemaps/Horners.gif
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Testing in Horner’s Syndrome
Cocaine test
Blocks the reuptake of norepinephrine
Normal pupil dilates
Horner’s: no dilation
Apraclonidine (alpha antagonist) reversal of
miosis on affected side
Paredrine test
Hydroxyamphetamine causes neurotransmitter
vesicle release if 3rd order neuron is intact
which results in mydriasis35
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Holmes-Adie Syndrome or
Ross’s Syndrome
Mydriasis
Loss of deep tendon reflexes
Diaphoresis
Accommodative paresis
Photophobia
Ciliary and spinal ganglia
1/8% pilocarpine test
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img.medscape.com/pi/emed/ckb/ophthalmology/1189694-1198462-92.jpg
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Third Nerve Palsy
Down and out (infraducted and abducted)
Ptosis (levator palpebrae some bilateral
innervation)
Mydriasis (iris sphincter from ipsilateral
Edinger-Westphal subnucleus)
Posterior communicating artery aneurysm
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http://www.nature.com/eye/journal/v20/n10/images/6702376f10.jpg
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www.netterimages.com/images/vpv/000/000/006/6994-0550x0475.jpg
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Motility Disorders
Abnormal movement
Nystagmus
Other
Cranial nerve III, IV, VI paresis
Parinaud’s
Supranuclear gaze palsy
Internuclear ophthalmoplegia
One and a half syndrome
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Nystagmus Periodic rhythmic ocular oscillation of the
eyes
Equal amplitude and velocity (pendular
nystagmus)
Slow initiating phase and a fast corrective phase
(jerk nystagmus)
Horizontal nystagmus
Vertical nystagmus
Rotary
Congenital nystagmus
Acquired nystagmus42
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Other Abnormal Eye Movements
Ocular bobbing
Ocular flutter
Opsoclonus
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img.medscape.com/pi/emed/ckb/clinical_procedures/79926-1412901-1189799-1585126.jpg
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www.pedseye.com/img/hyp_ex_02.jpg
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legacy.revoptom.com/handbook/images/62a.jpg
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Paresis of Individual Ocular Muscles
Graves disease
Orbit pathology
Cavernous sinus pathology
Myasthenia gravis
Guillain-Barré syndrome
Mitochondrial disease
Myopathies
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webhard.gnu.ac.kr/WebLink/limbh/data/fig/no_parinaud.jpg
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Parinaud’s or Dorsal Midbrain
Syndrome
Paralysis of voluntary upgaze
Accommodative paresis
Convergenceretraction nystagmus
Eyelid retraction (Collier’s sign)
Conjugate down gaze in the primary
position
Pineal mass49
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Progressive Supranuclear Palsy
Gait and balance problems
Difficulty with downgaze
Mood and behavior problems
Depression and apathy
Dementia
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www.hmc.org.qa/qmj/qmj_nov_2006/images/Image_QMJ_2006/Fig12_63.jpg
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http://www.google.com/imgres?imgurl=http://umed.med.utah.edu/
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Internuclear Ophthalmoplegia
Lack of conjugate adduction in the
ipsilateral MLF
Accommodation intact
Multiple sclerosis
Other pontine lesions such as CVA
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http://www.google.com/imgres?imgurl=http://umed.med.utah.edu
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Where pathway
What pathwayhttp://en.wikipedia.org/wiki/File:Ventral-dorsal_streams.svg
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Cortical Vision Disorders
Prosopagnosia
Inability to recognize familiar faces
Right occipitotemporallobe
Balint syndrome
Triad of:
Simultagnosia
Optic ataxia
Visual apraxia
Bilateral parietal lobe lesions
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References/Resources www.eyeweb.org
emedicine.medscape.com/ophthalmology
umed.med.utah.edu
Basics in neuro-ophthalmology by Kathleen B.
Digre, MD
Using the ophthalmoscope and viewing the
optic disc by Kathleen B. Digre, MD
www.jeffmann.net/Neuroguidemaps
uuhsc.utah.edu
www.kellogg.umich.edu
www.richmondeye.com57
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Questions and Answers
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