Vol. 268, No. 23 The Journal of Biological Chemistry

Copyright 0 1993 by the American Society for Biochemistry and Molecular Biology, Inc. 428 East Preston St., Baltimore. MD 21202 U.S.A.

August 15,1993

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CONTENTS*

MINIREVIEW 16966 Nucleotide excision repair, a tracking mechanism in search of damage. Lawrence Grossman and Sam Thiogalingam

COMMUNICATIONS 16974

Location of CD4 dimerization site explains critical role of CDR3-like region in HIV-1 infection and T-cell ac- tivation and implies a model for complex of coreceptor- 16979 MHC. Johannes P. M. Langedijk, Wouter C. Puijk, Willem Paul uan Hoorn, and Rob H. Meloen

Binding of wild type and chimeric arrestins to the m2 16987 muscarinic cholinergic receptor. Vsevolod V. Gureuich, Ricardo M. Richardson, Chng M. Kim, M. Marlene Hosey, and Jejjrey L. Benovic

Myosin light chain phosphorylation does not increase during yeast phagocytosis by macrophages. Primal de Lanerolle, Gayle Gorgas, Xiangquan Li, and Kimberly Schluns

The As adenosine receptor is the unique adenosine receptor which facilitates release of allergic mediators

Beawen, and Hydar Ali in mast cells. Vickram Ramkumar, Gary L. Stiles, Michael A.

Inhibition of the cellular secretion OF cholesteryl ester transfer protein by a variant protein Formed by alter- native splicing of mRNA. Elaine Quinet, Tsuei Ping Yang, Catherine Marinas, and Alan Tall 17010

NAD glycohydrolase specifically induced by retinoic acid in human leukemic HL-60 cells. Identification of the NAD glycohydrolase as leukocyte cell surface an- tigen CD38. Kenji Kontani, Hiroshi Nishinu, Yoshihuru O h k a , Katsunobu Takahashi, and Toshiaki Katada 17018

Thrombin exosite for fibrinogen recognition is par- tially accessible in prothrombin. Feng Ni, Qing Ning, Craig M. Jackson, and John W. Fenton I1

Human ABR encodes a protein with GAP" activity and homology to the DBL nucleotide exchange factor do- main. Nora Heisterkamp, Vesa Kaartinen, Simone wan Soest, Gary M. Bokoch, and John Croffen

16993

16999

17026

ARTICLES 17030

Mechanisms of upstream activation of the rrnD pro-

gert, and Karl Mueller moter PI of Escherichia coli. Peter Sander, Wilhelm Lan-

The tricarboxylic acid cycle in Dictyostelium discoi- deum. Systemic effects of including protein turnover in the current model. Fumihide Shiraishi and Michael A. 17045 Sauageau

Effects of competitive sodium-like antagonists on Na,K-ATPase suggest that cation occlusion from the cytoplasmic surface occurs in two steps. Eran Or, Peer David, Alla Shuinskaya, Daniel M. Tal, and Steven J. D. Karlish

HIV protease cleavage sites in proteins. Kw-Chen Chou A vectorized sequence-coupling model for predicting

Detection and characterization of cellular EGR-1 bind- ing to its recognition site. Xinmin Cao, Ratha Mahendran, Graeme R. Guy, and Y. H. Tan

17038

17051

17057

Apolipoprotein A-I domains involved in the activation of 1ecithin:cholesterol acyltransferase. Importance of the central domain. Qiang-Hw Meng, Laura Calabresi, Jean-Charles Fruchart, and Yves L. Marcel

Microheterogeneity around the reactive lysine residue

Hideyuki Komatsu and Katsuhisa Tawada in the myosin heavy chain from rabbit skeletal muscle.

Abnormal regulation of low density lipoprotein-sensi- tive events in a cholesterol transport mutant. Neera K. Dahl, William G. Gutheil, and Laura Liscum

cDNA cloning and gene expression analysis of the mi- crobial proteinase inhibitor of tobacco. Thierry Heitz, Pierrette Geoffroy, Annick Stintzi, Bernard Fritig, and Michel Legrand

piem and Ascaris suurn hemoglobins and to Leu-29 + Kinetics of ligand binding to Pseudoterranova deci-

Tyr sperm whale myoglobin mutant. Quentin H . Gibson, Rebecca Regan, John S. Olson, Theodore E . Carver, Brian Diron, Bill Pohajdak, Pawan K. Sharma, and Serge N. Vinogradow

Distinct activation domains within CAMP response ele- ment-binding protein (CREB) mediate basal and CAMP- stimulated transcription. Patrick G. Quinn

expression analysis of a chromosome 3p21 gene inac- Human aminoacylase- 1. Cloning, sequence, and

J . Burke, Dorothy L. Buchhugen, John D. Minna, and York tivated in small cell lung cancer. Robert M. Cook, Brian

E. Miller

Comparative studies of cardiac and skeletal sarco- plasmic reticulum ATPases. Effect of a phospholamban antibody on enzyme activation by Cas'. Thomas Cantil- ina, Yutaka Sagara, Giuseppe Inesi, and Larry R. Jones

ADP-ribosylation of G. by cholera toxin is potentiated by agonist activation of &adrenergic receptors in the absence of GTP. Frederic Bornancin, Ywes Audigier, and Marc Chabre

Mechanism of inactivation of S-adenosylhomocysteine hydrolase by (Z)-4',5'-didehydro-S'-deoxy-5'-fluoro- adenosine. Chong-Sheng Yuan, Jerry Yeh, Siming Liu, and Ronald T. Borchardt

Orientation of cholera toxin bound to target cells. Pal- mer A. Orlandi and Peter H. Fishman

Transduction of mitogenic activity of platelet-derived growth factor (PDGF) AB by PDGF-8 receptor without participation of PDGF-a receptor in vascular smooth muscle cells. Hiroshi Inui, Yutaka Kitami, Taka0 Kondo, and Tadashi Inagami

Deletion analysis of the Escherichia coIi rho-dependent transcription terminator trp t'. Fred Zalatan, Jill Gallo- way-Salvo, and Terry Platt

Cloning, nucleotide sequence, and expression of a p-

Pseudomonas fluorescens. Barry Shuman and Thomar A. hydroxybenzoate hydroxylase isozyme gene from

D ix

Isolation and analysis of the gene and cDNA for a 17063 Identification of an insulin-responsive element in the human Mu class glutathione S-transferase, GSTM4. promoter of the human gene for insulin-like growth Kenine E. Comstock, Kara J. Johnson, Dean Rifenbery, and factor binding protein-1. Adisak Suwanickul, Sheila L. W. David Henner Morris, and David R. Powell

* The CONTENTS arranged by Subject Categories will be found immediately following these CONTENTS. Full Instructions to Authors will be found in (1993) J. Biol. Chem. 268,14543-14551, and reprints may be obtained from the editorial office.

iii

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17120

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1

7145

7151

7155

17162

17173

17179

OmpF-Lpp signal sequence mutants with varying charge hydrophobicity ratios provide evidence for a phosphatidylglycerol-signal sequence interaction dur- ing protein translocation acroas the Escherichia coli inner membrane. David A. Phoenix, Ron Kusters, Chinami Hikita, Shoji Mizushima, and Ben de Kruijff

The regulatory gene, hXBP-1, and its target, HLA- DRA, utilize both common and distinct regulatory ele- ments and protein complexes. Paul D. Ponath, Deborah Fass, Hsiou-Chi Lwu, Laurie H. Glimcher, and Jack L. Strominger

Dissection of the human acetylcholinesterase active center determinants of substrate specificity. Identifi- cation of residues constituting the anionic site, the hy- drophobic site, and the acyl pocket. Arze Ordentlich, Dov Barak, Chanoch KronEn , Yehuda Flashner, Moshe Leitner,

Avzgdor Shafferman Yoffi Segall, Naomi Arrel, Sara Cohen, Baruch Velan, and

Co-ordinate and restricted expression of the Pro- XaaArg/Lys-specific GalNAc-transferase and the Gal NAc~1,4GlcNAc~1,2Mana-4-sulfotransferase. Shylaja M. Dharmesh, Timothy P. Skelton, and Jacques U. Baenziger

Purification and properties of Flenoprotein W from rat muscle. Susan C. Vendeland, Mtchael A. Bellstein, Chlarery L. Chen, Ole N. Jensen, Elwabeth Barofsky, and Phdrp D. Whanger

Phosphorylation of the human 46-kDa mannose 6- phosphate receptor in the cytoplasmic domain at serine 66. Frank Hemer, Christian Korner, and T h o r n Braulke

Neurotoxin binding and allosteric modulation at recep-

sodium channels. Vera L. Trainer, Eric Moreau, Denis Gue- tor sites 2 and 5 on purified and reconstituted rat brain

din, Daniel G. Baden, and William A. Catterall

Autoinhibitory domains of various CaB+ transporters cross-react. Agnes Enyedi and John T. Penniston

Charge pair interactions stabilizing ferredoxin-ferre- doxin reductase complexes. Identification by comple- mentary site-specific mutations. Mark E. Brandt and L a r r y E. Vickery

Regulation of tyrosine phosphorylation in neutrophils by the NADPH oxidase. Role of reactive oxygen inter- mediates. Lea Fialkow, Chi Kin Chan, S e g w Grinstein, and Gregory P. Downey

Implication of various forms of neurotensin receptors

cerebral neurons. Joelle Chabry, Georges Gaudriault, in the mechanism of internalization of neurotensin in

Jean-Pierre Vincent, and Jean Mazella

Generation and characterization of a competitive an- tagonist of human hepatocyte growth factor, HGF/ NKl. Nathalie A. Lokker and Paul J . Godowski

Isotopic labeling and EPR spectroscopy show that a tyrosine residue is the terminal electron donor, Z, in manganese-depleted photosystem I1 preparations. Re- nee J. Boerner and Bridgette A. Barry

protein phosphatase of Leishmania chagasi. James M. Molecular cloning and characterization of a 42-kDa

Reed Burns, Jr., Marilyn Parsons, Diane E. Rosman, and Steven G.

Synthesis of phosphatidylinositol 3,4,5-trisphosphate in permeabilized neutrophils regulated by receptors and G-proteins. Len Stephens, Trevor Jackson, and Phillip T. Hawkins

Polyamine-like actions of peptides derived from con- antokin-G, an N-methyl-D-aspartate (NMDA) antago- nist. Paulette Chandler, Michael Pennington, Maria-Luisa Maccecchini, Nashaat T. Nashed, and Phil Skolnick

Branch migration of Holliday junctions promoted by the Escherichia coli RuvA and RuvB proteins. I. Com-

Berndt Muller, Irina R. Tsaneva, and Stephen C. West parison of RuvAB- and RuvB-mediated reactions.

17185

17190

17199

17205

17211

17219

17225

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17240

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17261

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17277

17286

17300

17309

Branch migration of Holliday junctions promoted by the Escherichia coli RuvA and RuvB proteins. 11. In- teraction of RuvB with DNA. Berndt Muller, Irina R. Tsaneua, and Stephen C. West

Intracellular cGMP concentration in rod photorecep- tors is regulated by binding to high and moderate affin- ity cGMP binding sites. Rick H. Cote and Maura A. Brunnock

Epidermal growth factor modulates the lipolytic action of catecholamines in rat adipoeytes. Involvement of a GI protein. Francesc Tebar, Ignnsi Ramirez, and Maria Soley

Molecular cloning and characterization of cDNAs for the y- and e-subunits of mitochondrial FIFO ATP syn- thase from the sweet potato. Atsushi Moriknmi, Gaku Ehara, Kensuke Yuuki, and Kenzo Nakamura

Effect of tethered peptidylchloromethylketone inhibi- tors on thermal stability and domain interactions of urokinase and other serine proteases. Valery V. Novok- hatny, Leonid V . Medved, Andrew Mazar, and Kenneth C. Ingham

A point mutation of alanine -163 to threonine is re- sponsible for the defective secretion of high molecular weight kininogen by the liver of Brown Norway Kath- oliek rats. Izumi Hayashi, Shigeru Hoshiko, Osamu Maknbe, and Sachiko Oh-ishi

Rapid activation of GLUT-1 glucose transporter fol- lowing inhibition of oxidative phosphorylation in Clone 9 cells. Mangala Shetty, John N . Loeb, Karen Vikstrom, and Faramarz Ismail-Beigi

Lipopolysaccharide stimulates both nuclear localiza- tion of the nuclear factor nB 50-kDa subunit and loss of the 105-kDaprecursor in RAW264 macrophage-like cells. Shuung Zheng, Michael C. Brown, and Steven M. Taffet

Activation of dynamin GTPase by acidic phospholipids and endogenous rat brain vesicles. Pamela L. Tuma, Mary C. Stachnink, and Christine A. Collins

Identification of serine 624, aspartic acid 702, and histidine 734 as the catalytic triad residues of mouse dipeptidyl-peptidase IV (CD26). A member of a novel family of nonclassical serine hydrolases. Frgderic Dauid, Anne-Marie Bernard, Michel Pierres, and Didier Marguet

Isolation and heterologous expression of cloned cDNAs for two rabbit nasal microsomal proteins, CYP2AlO and CYP2A11, that are related to nasal microsomal cytochrome P450 form a. Hwei-Ming Peng, Xinxin Ding, and Minor J. Coon

Structural organization and genomic sequence of mouse syndecan-1 gene. Tapani Vihinen, Petri Auuinen, Leena Alanen-Kurki, and Markku Jalkanen

that is phosphorylated on tyrosine in response to plate- The a& integrin associates with a 190-kDa protein

let-derived growth factor. Neil S. Bartfeld, Elena B. Pas- quule, John E. Geltosky, and Luck R. Languino

Structural features of the human bradykinin B2 recep- tor probed by agonists, antagonists, and anti-idiotypic

Armin Maidhof, Martina Haasemann, Gerhard Brerpohl, antibodies. Said Abd Alla, Jorg Buschko, Ursula Quitterer,

Jochen Knolle, and Werner Muller-Ester1

Self-assembly and calcium-binding sites in laminin. A three-arm interaction model. Peter D. Yurchenco and Yi-Shan Cheng

Multifunctional RNA polymerase I1 initiation factor 6 from rat liver. Relationship between carboxyl-terminal domain kinase, ATPase, and DNA helicase activities. Hiroaki Serizawa, Ronald C. Conaway, and Joan Welib Conaway

Identification of the major phosphorylation sites of the

Rapp, and Terry D. Copeland Raf-1 kinase. Deborah K. Morrison, Gisela Heidecker, Ulf R.

The Journal of Ezological Chemistry (ISSN 0021-9258) is published three times per month by the American Society for Biochemistry and Molecular Biology, Inc., 428 East Preston Street Baltimore, MD 21202, U.S.A. Volume 268 for 1993: United States, $710; other countries, $860. Single copy: United States, $24.00 other countries, $28.00. Special subscription rates ar; avadable to members, graduate students, and postdoctoral fellows for personal use only. Qualifying forms are available from the ASBMB Office, 9650 Rockville Pike, Bethesda, MD 20814. Second class postage paid at Baltimore, MD 21202, U.S.A. and at additional mailing offices, Send address changes to The Journal of Biolopical Chemistry at 428 East Preston Street, Baltimore, MD 21202, U.S.A.

vi

17317 Regulation of expression of the CYPllA (P460,) gene

esters. Martine Begeot, Usha Shetty, Michael Kilgore, Michael in bovine ovarian luteal cells by forskolin and phorbol

Watermun, and Evan Simpson

17326 Stimulation of neutrophils with a chemoattractant ac- tivates several novel protein kinases that can catalyze the phosphorylation of peptides derived from the 47- kDa protein component of the phagocyte oxidase and

Ding and John A. Badwey myristoylated alanine-rich C kinase substrate. Jiabing

17334 Site-specific methylation inhibits transcriptional activ-

Xin-Hua Lin, Chan Guo, Li Juan Gu, and Thomas F. Dew1 ity of platelet-derived growth factor A-chain promoter.

17341 Cell type-specific regulation of SL-1 and SL-2 genes. Induction of the SL-2 gene but not the SL-1 gene by

phorbolesters. L. Jack Windsor, Hernan Grenett, Bente Bir- human keratinocytes in response to cytokines and

kehl-Hansen, M. Kirby Bodden, Jeffrey A. Engler, and Hen- ning Birkedal-Hansen

17348 Molecular and biochemical characterization of herbi- cide-resistant mutants of cyanobacteria reveals that phytoene desaturation is a rate-limiting step in carot- enoid biosynthesis. Daniel Chamovitz, Gerhard Sandmann, and Joseph Hirschberg

17354 Distinct mechanisms regulate interstitial collagenase and 92-kDa gelatinase expression in human monocytic- like cells exposed to bacterial endotoxin. Ulpu K. Saa- rialho-Kere, Howard G. Welgus, and William C. Parks

17362 Tumor-specific overexpression of a novel keratinocyte

tion of a cloned sequence activated during multistage lipid-binding protein. Identification and characteriza-

carcinogenesis in mouse skin. Peter Krieg, Sabine Feil, Gerhard Fiirstenberger, and G. T im Bowden

17370 Differential effect of brefeldin A on the biosynthesis of heparan sulfate and chondroitin/dermatan sulfate pro- teoglycans in rat ovarian granulosa cells in culture. Lars Uhlin-Hansen and Masaki Yamgishita

17377 Expression of alternatively spliced epidermal growth

Evidence for a novel module. Csaba Fiihp, Erzsebet Wolcz, factor-like domains in aggrecans of different species.

Marta Valyon, and Tibor T. Glant

17384 Specific nuclear protein binding to a negative regula- tory element on the human CYPlAl gene. Paul D. Boucher, Randall J . Ruch, and Ronald N. Hines

17392 Bovine seminal ribonuclease produced from a synthetic gene. Jin-So0 Kim and Ronald T. Raines

17397 Thromboxane Aa stimulates vascular smooth muscle hypertrophy by up-regulating the synthesis and release

Michael G. Davis, Michael W. Beckr, and Gerald W. Dorn II of endogenous basic fibroblast growth factor. Safdar Ali,

17404 Characterization of Chinese hamster ovary cell lines expressing human steroid &-reductase isozymes. Anice E. Thigpen, Kristine M. Cala, and David W. Russell

17413 Copurification of casein kinase I1 with 20 S prote-

subunit. Robert Ludemunn, Kenneth M. Lerea, and Joseph asomes and phosphorylation of a 30-kDa proteasome

D. Etlinger

17418 Preferential formation of C3b-IgG complexes in vitro and in vivo from nascent C3b and naturally occurring anti-band 3 antibodies. Hans U. Lutz, Pia Stammler, and Stephun Fasler

17427 Inhibition of kinesin synthesis and rapid anterograde axonal transport in vivo by an antisense oligonucleo- tide. Ani1 Amaratunga, Peter J . Morin, Kenneth S. Kosik, and Richard E. Fine

17431 Developmentally regulated changes in 1,2-diacylglyc- erol in Dictyostelium. Regulation by light and G pro- teins. Andrew B. Cubitt, Suranganie Dharmawardhnne, and Richard A. Firtel

17440 Isolation and characterization of a thiamin pyrophos- phokinase gene, THI80, from Saccharomyces cerevis- iae. Kazuto Nosaka, Yoshinobu Kaneko, Hiroshi Nishimura, and Akio Iwashima

17448 Adenovirus DNA polymerase is phosphorylated by a stably associated histone €I1 kinase. Muralidhara Rama- chundra and Radha Padmanabhan

17457

17463

17471

17478

17489

17495

7504

7513

7519

17528

17539

17547

17554

17559

17564

17571

17578

17588

Transcriptional modulation of platelet-activating fac- tor receptor gene expression by cyclic AMP. Maryse

Brum-Fernandes, and Marek Rola-Pleszczynski Thiuierge, Naima Alami, Eliane Muller, Artur J. de

The human S~bp-2, a DNA-binding protein specific to the single-strand& guanine-rich sequence related to the immunoglobulin p chain switch region. Yosho Fukita, Tatsunobu-Ryushin Mizuta, Michw Shirozu, Kazuo Ozawa, Akira Shimizu, and Tasuku Honjo

formed by CRP and CytR for repression and by CRP Characterization of promoter recognition complexes

and RNA polymerase for activation of transcription on

gaurd, Peter Birk Rasmussen, Poul Valentin-Hansen, and Pe- the Escherichia coli deoP2 promoter. Niels Erik M~l le -

ter E. Nielsen

Structure and chromosomal localization of the human constitutive endothelial nitric oxide synthase gene. Philip A. Marsden, Henry H. Q. Heng, Ste hen W Scherer, Robert J . Stewart, Anne V. Hall, Xino-Mei S f i , Lap-Chee Tsui, and Keith T. Schnppert

Cytokine regulation of low density lipoprotein receptor gene transcription in HepG2 cells. Alison T. Stopeck, Andrew C. Nicholson, Francesco P. Mancini, and David P. Hajjar

Single amino acid substitutions affecting the substrate specificity of the Escherichia coli K-12 nucleoside-spe- cific Tsx channel. Hafida Fsihi, Brunhilde Kottwitz, and Erhard Bremer

Expression and characterization of the N-terminal do- main of an oleosin protein from sunflower. Ming Li, James S. Keddie, Linda J. Smith, David C. Clark, and Denis J . Murphy

A peptide from ICAM-2 binds to the leukocyte integrin CD1 la/CD18 and inhibits endothelial cell adhesion. Rui Li, Pekka Nortamo, Leena Valmu, Martti Tolvanen, Jarkko Huuskonen, Carmela Kantor, and Carl G. Gahmberg

Receptor accessory factor enhances specific DNA bind-

Kupfer, Keith B. Marschke, Elizabeth M. Wilson, and Frank ing of androgen and glucocorticoid receptors. Stuart R.

S. French

Characterization of two allelic variants of a human pregnancy-specific glycoprotein gene. Ke-Jian Lei, Chen

and Janice Yang Chou Wang, Margaret E. Chamberlin, Ji-Lan Liu, Chi-Jiunn Pan,

Localization of the disulfide bonds in the NHZ-terminal domain of the cellular receptor for human urokinase- type plasminogen activator. A domain structure be- longing to a novel superfamily of glycolipid-anchored membrane proteins. Michael Pbug, Marianne Kjalke, Ebbe RBnne, Ulrich Weidle, Gunilla HByer-Hansen, and Keld DaM

Conserved cysteine residues are critical for the enzy- matic function of the lymphocyte-specific tyrosine pro- tein kinase ~ 6 6 ” ~ . Andre VeiUette, Serge Dumont, and Mar- ielle Fournel

Identification of TFIID components required for tran- scriptional activation by upstream stimulatory factor. Tetsuro Kokubo, Ritsuko Takada, Shinya Yamashits Da- Wei Gong, Robert G. Roeder, Masami Horikoshi, and Yoshihiro Nakatani

Identification of the phosphorylated region responsible for the permissive activation of protein kinase C. Syluie M. Cazaubon and Peter J . Parker

Mechanism of site-specific recombination. Logic of as- sembling recombinase catalytic site from fractional ac- tive sites. Jehee Lee and Makkuni Jayaram

RecA binding to bulge- and mismatch-containing DNAs. Certain single base mismatches provide strong signals for RecA binding equal to multiple base bulges. Yuh-Hwa Wang, Carl D. Bortner, and Jack Griffith

Tyrosine phosphorylation of a 100-kDa protein is cor- related with cytotoxic T-lymphocyte function. Evi- dence from cis unsaturated fatty acid and phenylarsi- neoxide inhibition. Alberta Anel and Alan M. Kleinfeld

Heterogeneity of recombinant human antithrombin I11 expressed in baby hamster kidney cells. Effect of gly- cosylation differences on heparin binding and struc- ture. Bingqi Fan, Brenda C. Crews, Illarion V . Turko. Jean Choay, Gerd Zettlmeifil, and Peter Gettrns

vii

17597 Identification of a regulatory region of integrin 191 sub- unit using activating and inhibiting antibodies. Yoshi- katu Takoda and Wilma Puzon

17602 Model of lactose repressor core based on alignment with sugar-binding proteins is concordant with genetic and chemical data. Jeffry C. Nichols, Nand K. Vyas, Florante A. Quiocho, and Kathleen S. Matthews

17613 Lysine 84 is at the subunit interface of lac repressor protein. Wen-I. Chang, John S. Olson, and Kathleen S. Matthews

17623 Isolation and characterization of a cDNA encoding rat liver cytmlic epoxide hydrolase and its functional expression in Escherichia coli. Michael Knehr, Helmut

and Franz Oesch Thomas, Michuel Arand, Thomas Gebel, Hans-Dieter Zeller,

17628 Molecular cloning and expression of murine liver sol- uble epoxide hydrolase. David F. Grant, David H. Storms, and Bruce D. Hammock

17634 Isolation and characterization of LIP6. A lipoate bio- synthetic locus of Saccharomyces cereuieiae. €‘avo1 s u b and Nancy C. Martin

17640 Separation of splicing factor SF3 into two components and purification of SF3a activity. Reto Brosi, Hans-Peter Hauri, and Angela Kramer

17647

17647

17647

17648

17650

ADDITIONS AND CORRECTIONS Locating a low density lipoprotein-targeting domain of human apolipoprotein B- 100 by expressing a mini-gene construct in transgenic mice. Vol. 266 (1991) 20893-

K. Y. Lei, and Lawrence Chan 20898. Weijun Xiong, Eva Zsigmond, Antonio M. Gotto, Jr.,

Transgenic mice expressing full-length human apo-lip- oprotein B-100. Full-length human apolipoprotein B mRNA is essentially not edited in mouse intestine or liver. Vol. 267 (1992) 21412-21420. Weijun Xiong, Eua Zsigmond, Antonio M. Gotto, Jr., Lixing W. Reneker, and Lawrence Chan

Cloning a rat meprin cDNA reveals the enzyme is a

Johnson and Lours B. Hersh heterodimer. Vol. 267 (1992) 13606-13612. Gary D.

Three-dimensional structures of the periplasmic lysine/ arginine/ornithine-binding protein with and without a ligand. Vol. 268 (1993) 11348-11366. Byung-Ha Oh, Jayvardhan Pundit, Chul-Hee Kang, Kishiko Nikaido, Sabiha Gokcen, Giovanna Ferro-Luzzi Ames, and Sung-Hou Kim

Cloning and expression of PTP-PEST. A novel, human, nontransmembrane protein tyrosine phosphatase. Vol.

Sommercorn, and Nicholas K. Tonks 268 (1993) 6622-6628. Qing Yang, Deborah Go, James

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Vol. 268, No. 23 The Journal of Biological Chemistry

CONTENTS Arranged by Subject Categories

August 15, 1993

MINIREVIEW

16871 Nucleotide excision repair, a tracking mechanism in search of damage. Lawrence Grossman and Sam Thiagalingam

CARBOHYDRATES, LIPIDS, AND OTHER NATURAL PRODUCTS

17096 Co-ordinate and restricted expression of the Pro- XaaArgILys-specific GalNAc-transferase and the Gal

Shylaja M. Dharmesh, Timothy P. Skelton, and Jacques U. NAc~1,4GlcNAc~1,2Mana-4-sulfotransferase.

Baenziger

17489 Cytokine regulation of low density lipoprotein receptor

Andrew C. Nicholson, Francesco P. Mancini, and David P. gene transcription in HepG2 cells. Alison T. Stopeck,

Hajjar

CELL BIOLOGY AND METABOLISM

e16879 Binding of wild type and chimeric arrestins to the m2 muscarinic cholinergic receptor. Vseuolod V. Gureuich, Ricardo M. Richardson, Chong M. Kim, M. Marlene Hosey, and Jeffrey L. Benouic

-16883 Myosin light chain phosphorylation does not increase during yeast phagocytosis by macrophages. Primal de Lanerolle, Gayle Gorgas, Xiangquan Li, and Kimberly Schluns

e16887 The AS adenosine receptor is the unique adenosine receptor which facilitates release of allergic mediators

Beauen, and Hydar Ali in mast cells. Vickram Ramkumar, Gary L. Stiles, Michael A.

016891 Inhibition of the cellular secretion of cholesteryl ester transfer protein by a variant protein formed by alter- native splicing of mRNA. Elaine Quinet, Tsuei Ping Yang, Catherine Marims, and Alan Tall

016895 NAD glycohydrolase specifically induced by retinoic acid in human leukemic HL-60 cells. Identification of the NAD glycohydrolase as leukocyte cell surface an- tigen CD38. Kenji Kontani, Hiroshi Nishina, Yoshiharu Ohoka, Katsunobu Takahnshi, and Toshiaki Katada

16917 The tricarboxylic acid cycle in Dictyostelium discoi- deum. Systemic effects of including protein turnover in the current model. Fumihide Shiraishi and Michael A. Sauageau

16979 Abnormal regulation of low density lipoprotein-sensi- tive events in a cholesterol transport mutant. Neera K. Dahl, William G. Gutheil, and Laura Liscum

17026 ADP-ribosylation of G. by cholera toxin is potentiated by agonist activation of &adrenergic receptors in the absence of GTP. FredEric Bornancin, Yues Audigier, and Marc Chabre

17038 Orientation of cholera toxin bound to target cells. Pal- mer A. Orlandi and Peter H. Fishman

17045 Transduction of mitogenic activity of platelet-derived

participation of PDGF-a receptor in vascular smooth growth factor (PDGF) AB by PDGF-8 receptor without

muscle cells. Hiroshi Inui, Yutaka Kitami, Taka0 Kondo, and Tadashi Inagami

17063 Identification of an insulin-responsive element in the promoter of the human gene for insulin-like growth factor binding protein-1. Adisak Suwanickul, Sheila L. Morris, and David R. Powell

17108 Phosphorylation of the human 46-kDa mannose 6- phosphate receptor in the cytoplasmic domain at serine 66. Frank Hemer, Christian Korner, and Thomas Braulke

17131 Regulation of tyrosine phosphorylation in neutrophils by the NADPH oxidase.. Role of reactive oxygen inter-

Gregory P. Downey mediates. Lea Fiulkow, Chi Kzn Chan, Sergm Grinstezn, and

17162

17199

17225

17240

17270

17277

17309

17354

17362

17370

17397

17413

17427

17431

17457

17559

17578

17597

Synthesis of phosphatidylinositol 3,4,5-trisphosphate

and G-proteins. Len Stephens, Treuor Jackson, and Phillip in permeabilized neutrophils regulated by receptors

T. Hawkins

Epidermal growth factor modulates the lipolytic action of catecholamines in ra t adipocytes. Involvement of a GI protein. Francesc Tebar, Ignasi Ramirez, and Maria Soley

Rapid activation of GLUT-1 glucose transporter fol- lowing inhibition of oxidative phosphorylation in Clone

Faramarz Ismail-Beigi 9 cells. Mangala Shetty, John N. Loeb, Karen Vikstrom, and

Activation of dynamin GTPase by acidic phospholipids and endogenous rat brain vesicles. Pamela L. Tuma, Mary C. Stachniak, and Christine A. Collins

The a& integrin associates with a 190-kDa protein that is phosphorylated on tyrosine in response to plate- let-derived growth factor. Neil S. Bartfeld, Elena B. Pas- quale, John E. Geltosky, and Lucia R. Languino

Structural features of the human bradykinin B2 recep- tor probed by agonists, antagonists, and anti-idiotypic

Armin Maidhof, Martina Haasemann, Gerhard Breipohl, antibodies. Said Abd Alla, Jorg Buschko, Ursula Quitterer,

Jochen Knolle, and Werner Muller-Ester1

Identification of the major phosphorylation sites of the

Rapp, and Terry D. Copeland Raf-1 kinase. Deborah K. Morrison, Gisela Heidecker, Ulf R.

Distinct mechanisms regulate interstitial collagenase and 92-kDa gelatinase expression in human monocytic- like cells exposed to bacterial endotoxin. Ulpu K. Saa- rialho-Kere, Howard G. Welgus, and William C. Parks

Tumor-specific overexpression of a novel keratinocyte

tion of a cloned sequence activated during multistage lipid-binding protein. Identification and characteriza-

carcinogenesis in mouse skin. Peter Krieg, Sabine Feil, Gerhard Fiirstenberger, and G. Tim Bowden

Differential effect of brefeldin A on the biosynthesis of heparan sulfate and chondroitin/dermatan sulfate pro-

Lars Uhlin-Hansen and Masaki Yanagishita teoglycans in rat ovarian granulosa cells in culture.

hypertrophy by up-regulating the synthesis and release Thromboxane A2 stimulates vascular smooth muscle

of endogenous basic fibroblast growth factor. Safdar Ali, Michael G. Dauis, Michael W. Becker, and Gerald W. Dorn 11

Copurification of casein kinase. I1 with 20 S prote- asomes and phosphorylation of a 30-kDa proteasome subunit. Robert Ludemann, Kenneth M. Lerea, and Joseph D. Etlinger

Inhibition of kinesin synthesis and rapid anterograde axonal transport in vivo by an antisense oligonucleo- tide. Ani1 Amaratunga, Peter J. Morin, Kenneth S. Kosik, and Richard E. Fine

Developmentally regulated changes in 1,2-diacylglyc- erol in Dictyostelium. Regulation by light and G pro-

Richard A. Firtel teins. Andrew B. Cubitt, Suranganie Dharmawardhane, and

Transcriptional modulation of platelet-activating fac- tor receptor gene expression by cyclic AMP. Maryse Thiuierge, Naima Alaml, Eliane Muller, Artur J . de Brum-Fernundes, and Marek Rola-Pleszczynski

Identification of the phosphorylated region responsible for the permissive activation of protein kinase C. Syluie M. Cazaubon and Peter J. Parker

Tyrosine phosphorylation of a 100-kDa protein is cor- related with cytotoxic T-lymphocyte function. Evi- dence from cis unsaturated fatty acid and phenylarsi- neoxide inhibition. Alberta Anel and Alan M. Kleinfeld

Identification of a regulatory region of integrin B1 sub- unit using activating and inhibiting antibodies. Yoshi- kazu Takada and Wilma Puzon

Indicates a Communication Vlll ...

ix

ENZYMOLOGY 16958 Isolation and analysis of the gene and cDNA for a

human Mu class glutathione S-transferase, GSTM4. Kenine E. Comstock, Kara J . Johnson, Dean Rifenbery, and W. -David Henner

17030 Mechanism of inactivation of S-adenosylhomocysteine hydrolase by (Z)-4',S'-didehydro-S'-deoxy-S'-fluoro- adenosine. Chong-Sheng Yuun, Jerry Yeh, Siming Liu, and Ronald T. Borchurdt

17057 Cloning, nucleotide sequence, and expression of a p- hydroxybenzoate hydroxylase isozyme gene from Pseudomonas fluorescens. Barry Shuman and Thomas A. Dix

17083 Dissection of the human acetylcholinesterase active center determinants of substrate specificity. Identifi- cation of residues constituting the anionic site, the hy-

Barak, Chumch Kronmnn, Yehuda Flnshner, Moshe Leitner, drophobic site, and the acyl pocket. A r k Ordentlich, Dou

Yoffc Segall, Naomi Ariel, Sara Cohen, Baruch Velan, and Avigdor Shufferman

17155 Molecular cloning and characterization of a 42-kDa protein phosphatase of Leishmania chagasi. James M. Burns, Jr., Marilyn Parsons, Diane E. Rosmnn, and Steven G. Reed

17247 Identification of serine 624, aspartic acid 702, and histidine 734 as the catalytic triad residues of mouse dipeptidyl-peptidase IV (CD26). A member of a novel family of nonclassical serine hydrolases. Frediric David, Anne-Marie Bernard, Michel Pierres, and Didier Marguet

17326 Stimulation of neutrophils with a chemoattractant ac- tivates several novel protein kinases that can catalyze the phosphorylation of peptides derived from the 47- kDa protein component of the phagocyte oxidase and myristoylated alanine-rich C kinase substrate. Jiabing Ding and John A. Badwey

17341 Cell type-specific regulation of SL-1 and SL-2 genes. Induction of the SL-2 gene but not the SL-1 gene by human keratinocytes in response to cytokines and phorbolesters. L. Jack Windsor, Hernan Grenett, Bente Bir- kedal-Hansen, M. Kirby Bodden, Jeffrey A. Engler, and Hen- ning Birkedal-Hansen

17348 Molecular and biochemical characterization of herbi- cide-resistant mutants of cyanobacteria reveals that phytoene desaturation is a rate-limiting step in carot- enoid biosynthesis. Daniel Chumovitz, Gerhurd Sandmnnn, and Joseph Hirschberg

17392 Bovine seminal ribonuclease produced from a synthetic gene. Jin-So0 Kim and Ronald T. Raines

17404 Characterization of Chinese hamster ovary cell lines expressing human steroid Sa-reductase isozymes. Anice E. Thigpen, Kristine M. Cala, and David W. Russell

17547 Conserved cysteine residues are critical for the enzy- matic function of the lymphocyte-specific tyrosine pro- tein kinase pS6"'. Andre Veillette, Serge Dumont, and Mar- i e l l e Fournel

MEMBRANES AND BIOENERGETICS 16929 Effects of competitive sodium-like antagonists on

Na,K-ATPase suggest that cation occlusion from the cytoplasmic surface occurs in two steps. Eran Or, Peer David, Alla Shainskaya, Daniel M. Tal, and Steven J . D. Karlish

17018 Comparative studies of cardiac and skeletal sarco- plasmic reticulum ATPases. Effect of a phospholamban antibody on enzyme activation by Caz+. Thomas Cantil- inn, Yutaka Sagara, Giuseppe Inesi, and Larry R. Jones

17069 OmpF-Lpp signal sequence mutants with varying charge hydrophobicity ratios provide evidence for a phosphatidylglycerol-signal sequence interaction dur- ing protein translocation across the Escherichia coli inner membrane. David A. Phoenix, Ron Kusters, Chinami Hikita, Shoji Mizushima, and Ben de Kruijff

17114 Neurotoxin binding and allosteric modulation a t recep- tor sites 2 and 5 on purified and reconstituted rat brain sodium channels. Vera L. Trainer, Eric Moreau, Denis Gue- din, Daniel G. Baden, and William A. Catterall

17120

17151

17190

17205

17418

17513

Autoinhibitory domains of various Ca2+ transporters cross-react. Agnes Enyedi and John T. Penniston

Isotopic labeling and EPR spectroscopy show that a tyrosine residue is the terminal electron donor, Z, in manganese-depleted photosystem I1 preparations. Re- nee J . Boerner and Bridgette A. Barry

Intracellular cGMP concentration in rod photorecep- tors is regulated by binding to high and moderate affin- ity cGMP binding sites. Rick H. Cote and Maura A. Brunnock

Molecular cloning and characterization of cDNAs for the y- and c-subunits of mitochondrial FIFO ATP syn- thase from the sweet potato. Atsushi Morikami, Gaku Ehura, Kensuke Yuuki, and Kenzo Nakamura

Preferential formation of C3b-IgG complexes in vitro and in uiuo from nascent C3b and naturally occurring anti-band 3 antibodies. Hans U. Lutz, Pia Stammler, and Stephun Fasler

A peptide from ICAM-2 binds to the leukocyte integrin CD1 la/CD18 and inhibits endothelial cell adhesion. Rui Li, Pekka Nortamo, Leena Valmu, Martti Tolvanen, Jarkko Huuskonen, Carmela Kantor, and Carl G. Gahmbeg

NUCLEIC ACIDS, PROTEIN SYNTHESIS, AND MOLECULAR GENETICS

-16903

16907

16949

16987

16999

17010

17051

17074

17145

17179

17185

17219

17233

Human ABR encodes a protein with GAP" activity and homology to the DBL nucleotide exchange factor do- main. Nora Heisterkamp, Vesa Kaartinen, Simone van Soest, Gary M. Bokoch, and John Groffen

Mechanisms of upstream activation of the rrnD pro- moter PI of Escherichia coli. Peter Sander, Wilhelm Lan- gert, and Karl Mueller

Detection and characterization of cellular EGR-1 bind- ing to its recognition site. Xinmin Cao, Ratha Mahendran, Graeme R. Guy, and Y. H. Tan

cDNA cloning and gene expression analysis of the mi-

Pierrette Geoffroy, Annick Stintzi, Bernard Fritig, and Michel crobial proteinase inhibitor of tobacco. Thierry Heitz,

Legrand

Distinct activation domains within CAMP response ele-

stimulated transcription. Patrick G. Quinn ment-binding protein (CREB) mediate basal and CAMP-

Human aminoacylase-1. Cloning, sequence, and expression analysis of a chromosome 3p21 gene inac- tivated in small cell lung cancer. Robert M. Cook, Brian J. Burke, Dorothy L. Buchhagen, John D. Minna, and York E. Miller

Deletion analysis of the Escherichia coli rho-dependent transcription terminator trp t'. Fred Zalatan, Jill Gallo- way-Salvo, and Terry Platt

The regulatory gene, hXBP-1, and its target, HLA- DRA, utilize both common and distinct regulatory ele- ments and protein complexes. Paul D. Ponath, Deborah Fass, Hsiou-Chi Lwu, Laurie H. Glimcher, and Jack L. Strominger

Generation and characterization of a competitive an- tagonist of human hepatocyte growth factor, HGF/ NK1. Nathulie A. Lokker and Paul J . Godowski

Branch migration of Holliday junctions promoted by

parison of RuvAB- and RuvB-mediated reactions. the Escherichia coli RuvA and RuvB proteins. I. Com-

Berndt Muller, Irina R. Tsaneva, and Stephen C. West

Branch migration of Holliday junctions promoted by the Escherichia coli RuvA and RuvB proteins. 11. In- teraction of RuvB with DNA. Berndt Muller, Irina R. Tsaneva, and Stephen C. West

A point mutation of alanine -163 to threonine is re- sponsible for the defective secretion of high molecular weight kininogen by the liver of Brown Norway Kath- oliek rats. Izumi Hayashi, Shigeru Hoshiko, Osamu Makabe, and Sachiko Oh-ishi

Lipopolysaccharide stimulates both nuclear localiza- tion of the nuclear factor KB SO-kDa subunit and loss of the 106-kDa precursor in RAW264 macrophage-like cells. Shuang Zheng, Michael C. Brown, and Steven M. Taffet

Indicates a Communication

X

17253

17261

17300

17317

17334

17377

17384

17440

17448

17463

17471

17478

17495

17519

17528

17571

17623

17628

Isolation and heterologous expression of cloned cDNAs

and CYP2A11, that are related to nasal microsomal for two rabbit nasal microsomal proteins, CYP2A10

cytochrome P460 form a. Hwei-Ming Peng, Xinxin Ding, and Minor J . Coon

syndecan-1 gene. Tapani Vihinen, Petri Auuinen, Leenu Structural organization and genomic sequence of mouse

Alanen-Kurki, and Markku Jalkanen

Multifunctional RNA polymerase I1 initiation factor 8 from rat liver. Relationship between carboxyl-terminal domain kinase, ATPase, and DNA helicase activities. Hiroaki Serizawa, Ronald C. Conuway, and Joan Weliky Conaway

Regulation of expression of the CYPllA (P460,) gene in bovine ovarian luteal cells by forskolin and phorbol esters. Martine Begeot, Ushu Shetty, Michael Kilgore, Michael Waterman, and Evan Simpson

Site-specific methylation inhibits transcriptional activ- ity of platelet-derived growth factor A-chain promoter. Xin-Hua Lin, Chun Guo, Li Juan Gu, and Thomas F. Deuel

Expression of alternatively spliced epidermal growth

Evidence for a novel module. Csaba Fulop, Erzskbet Walcz, factor-like domains in aggrecans of different species.

Marta Valyon, and Tibor T. Glant

tory element on the human CYPlAl gene. Paul D. Specific nuclear protein binding to a negative regula-

Boucher, Randall J. Ruch, and Ronald N. Hines

Isolation and characterization of a thiamin pyrophos- phokinase gene, THI80, from Saccharomyces cerevis- iae. Kazuto Nosaka, Yoshinobu Kaneko, Hiroshi Nishimura, and Akw Iwashima

Adenovirus DNA polymerase is phosphorylated by a stably associated histone H1 kinase. Muralidhara Rama- chandra and Radhu Padmanubhan

The human Srbp-2, a DNA-binding protein specific to the single-stranded guanine-rich sequence related to the immunoglobulin p chain switch region. Yosho Fukita, Tatsunobu-Ryushin Mizuta, Michw Shirozu, Kazuo Ozawa, Akira Shimizu, and Tasuku Honjo

Characterization of promoter recognition complexes formed by CRP and CytR for repression and by CRP and RNA polymerase for activation of transcription on the Escherichia coli deoP2 promoter. Niels Erik M6U.e- guard, Peter Birk Rasmussen, Paul Valentin-Hansen, and Pe- ter E. Nielsen

constitutive endothelial nitric oxide synthase gene. Structure and chromosomal localization of the human

Philip A. Marsden, Henry H. Q. Heng, Stephen W. Scherer, Robert J . Stewart, Anne V. Hall, X&-Mei Shi, Lap-Chee Tsui, and Keith T. Schappert

specificity of the Escherichia coli IC-12 nucleoside-spe- Single amino acid substitutions affecting the substrate

cific Tsx channel. Hafida Fsihi, Bmnhilde Kottwitz, and Erhurd Bremer

Receptor accessory factor enhances specific DNA bind-

Ku fer, Keith B. Marschke, Elizabeth M. Wilson, and Frank ing of androgen and glucocorticoid receptors. Stuart R.

S. french

Characterization of two allelic variants of a human pregnancy-specific glycoprotein gene. Ke-Jian Lei, Chen

and Janice Yang Chou Wang, Margaret E. Chumberlin, Ji-Lan Liu, Chi-Jiunn Pan,

RecA binding to bulge- and mismatch-containing DNAs. Certain single base mismatches provide strong signals for RecA binding equal to multiple base bulges. Yuh-Hwa Wang, Carl D. Bortner, and Jack Griffith

Isolation and characterization of a cDNA encoding rat

expression in Escherichia coli. Michael Knehr, Helmut liver cytosolic epoxide hydrolase and its functional

Thorn, Michael Arand, Thomas Gebel, Hans-Dieter ZeUer, and Franz Oesch

Molecular cloning and expression of murine liver sol- uble epoxide hydrolase. David F. Grant, David H. Storms, and Bruce D. Hammock

17634

17640

17647

016875

016899

16938

16966

16974

16993

17103

17126

17138

17173

17211

1'

7286

7504

7539

17554

Isolation and characterization of LIP5. A lipoate bio- synthetic locus of Saccharomyces cerevisiae. Pavol Sub and Nancy C. Martin

and purification of SF3a activity. Reto Brosi, Hans-Peter Separation of splicing factor SF3 into two components

Hauri, and Angela Kramer

Transgenic mice expressing full-length human apo-lip- oprotein B-100. Full-length human apolipoprotein B mRNA is essentially not edited in mouse intestine or

Zsigmnd, Antonio M. Gotto, Jr., Lixing W. Reneker, and liver. Vol. 267 (1992) 21412-21420. Weijun Xiong, Eva

Lawrence Chun

PROTEIN CHEMISTRY AND STRUCTURE Location of CD4 dimerization site explains critical role of CDR3-like region in HIV-1 infection and T-cell ac- tivation and implies a model for complex of coreceptor- MHC. Johunnes P. M. Langedijk, Wouter C. Puijk, Willem Paul van Hoorn, and Rob H. Meloen

Thrombin exosite for fibrinogen recognition is par- tially accessible in prothrombin. Feng Ni, Qing Ning, Craig M. Jackson, and John W. Fenton II A vectorized sequence-coupling model for predicting HIV protease cleavage sites in proteins. Kuo-Chen Chou

Apolipoprotein A-I domains involved in the activation of 1ecithin:cholesterol acyltransferase. Importance of

Jean-Charles Fruchurt, and Yves L. Marcel the central domain. Qiang-Hua Meng, Laura Calobresi,

Microheterogeneity around the reactive lysine residue

Hideyuki Komatsu and Katsuhisa Tawada in the myosin heavy chain from rabbit skeletal muscle.

Kinetics of ligand binding to Pseudoterranova deci- piem and Ascaris suum hemoglobins and to Leu-29 4

Rebecca Regan, John S. Olson, Theodore E. Carver, Brian Tyr sperm whale myoglobin mutant. Quentin H. Gibson,

Dixon, Bill Pohjdak, Pawan K. Shurma, and Serge N. Vimgradou

Purification and properties of selenoprotein W from rat muscle. Susan C. Vendeland, Michael A. Beilstein, Chiareiy L. Chen, Ole N. Jensen, Elisabeth Barofsky, and Philip D. Whunger

Charge pair interactions stabilizing ferredoxin-ferre- doxin reductase complexes. Identification by comple-

Larry E. Vickery mentary site-specific mutations. Mark E. Brandt and

in the mechanism of internalization of neurotensin in Implication of various forms of neurotensin receptors

cerebral neurons. J d l e Chubry, Georges Gaudrinult, Jean-Pierre Vincent, and Jean Mazella

Polyamine-like actions of peptides derived from con- antokin-G, an N-methyl-D-aspartate (NMDA) antago-

Maccecchini, Nashont T. Nashed, and Phil Skolnick nist. Paulette Chandler, Michael Pennington, Maria-Luisa

Effect of tethered peptidylchloromethylketone inhibi- tors on thermal stability and domain interactions of urokinase and other serine proteases. Valery V. Novok- hutny, Leonid V. Medved, Andrew Mazar, and Kenneth C. Inghum

Self-assembly and calcium-binding sites in laminin. A three-arm interaction model. Peter D. Yurchenco and Yi-Shun Cheng

Expression and characterization of the N-terminal do- main of an oleosin protein from sunflower. Ming Li, James S. Keddie, Linda J. Smith, David C. Clark, and Denis J. Murphy

Localization of the disulfide bonds in the NH2-terminal domain of the cellular receptor for human urokinase- type plasminogen activator. A domain structure be- longing to a novel superfamily of glycolipid-anchored membrane proteins. Michael Ploug, Marianne Kjalke, Ebbe RBnne, Ulrich Weidle, GuniUa H@yer-Hansen, and Keld Damd

scriptional activation by upstream stimulatory factor., Identification of TFIID components required for tran-

Tetsum Kokubo, Ritsuko Takada, Shtnya Yamashita, Da- Wet Gong, Robert G. Roeder, Masami Horikoshi, and Yoshihiro Nakatani

Indicates a Communication

xi

17564 Mechanism of site-specific recombination. Logic of as- sembling recombinase catalytic site from fractional ac- tive sites. Jehee Lee and Makkuni Jayaram

17588 Heterogeneity of recombinant human antithrombin I11 expressed in baby hamster kidney cells. Effect of gly- cosylation differences on heparin binding and struc- ture. Bingqi Fan, Brenda C. Crews, Illorion V. Turko, Jean Choay, Gerd Zettlmetfil, and Peter Gettins

17602 Model of lactose repressor core based on alignment with sugar-binding proteins is concordant with genetic and chemical data. Jeffry C. Nichols, Nand K. Vyas, Florante A. Quiocho, and Kathleen S. Matthews

17613 Lysine 84 is at the subunit interface of lac repressor protein. Wen-I. Chung, John S. Olson, and Kathleen S. Matthews

17647 Locating a low density lipoprotein-targeting domain of human apolipoprotein B- 100 by expressing a mini-gene construct in transgenic mice. Vol. 266 (1991) 20893- 20898. Weijun Xiong, Eva Zsigmond, Antonio M. Gotto, Jr., K. Y . Lei, and Lawrence Chan

17647 Cloning a rat meprin cDNA reveals the enzyme is a heterodimer. Vol. 267 (1992) 13606-13612. Gary D. Johnson and Louis B. Hersh

17648 Three-dimensional structures of the periplasmic lysine/ argininelornithine-binding protein with and without a

Jayuardhun Pundit, Chul-Hee Kang, Kishiko Niku 0, Sabha ligand. Vol. 268 (1993) 11348-11366. Byu2-H" Oh,

Gokcen, Giouanna Ferro-Luzzi Ames, and Sung-Hou Kim 17650 Cloning and expression of PTP-PEST. A novel, human,

nontransmembrane protein tyrosine phosphatase. Vol. 268 (1993) 6622-6628. Qing Yang, Deborah Co, James Sommercorn, and Nicholas K. Tonks

Alami, Naima, 17457

Ali, Hydar, 16887 Alanen-Kurki, Leena, 17261

Alla, Said Abd, 17277 Ali, Safdar, 17397

Amaratunga, Anil, 17427 Anel, Alberto, 17578

Ariel, Naomi, 17083 Arand, Michael, 17623

Auvinen, Petri, 17261 Audigier, Yves, 17026

Badwey, John A,, 17326 Baden, Daniel G., 17114

Baenziger, Jacques U., 17096 B a r d , Dov, 17083

Barry, Bridgette A,, 17151 Barofsky, Elisabeth, 17103

Bartfeld, Neil S., 17270 Beaven, Michael A., 16887 Becker, Michael W., 17397 Begeot, Martine, 17317 Beilstein, Michael A., 17103 Benovic, Jeffrey L., 16879 Bernard, Anne-Marie, 17247 Birkedal-Hansen, Bente,

Birkedal-Hansen, Henning,

Bodden, M. Kirby, 17341 Boerner, Renee J., 17151 Bokoch, Gary M., 16903 Borchardt, Ronald T., 17030 Bornancin, Frbdbric, 17026 Bortner, Carl D., 17571 Boucher, Paul D., 17384

Brandt, Mark E., 17126 Bowden, G . Tim, 17362

Braulke. Thomas, 17108 Breipohl, Gerhard, 17277

Brosi, &to, 17640 Bremer, Erhard, 17495

Brown, Michael C., 17233 Brunnock, Maura A., 17190 Buchhagen, Dorothy L.,

Burke, Brian J., 17010 Burns, James M., Jr., 17155 Buschko, Jorg, 17277 Cala, Kristine M., 17404

Cantilina, Thomas, 17018 Calabresi, Laura, 16966

Cao, Xinmin, 16949 Carver, Theodore E., 16993

Cazaubon, Sylvie M., 17559 catterall, William A., 17114

Chabry, Joelle, 17138 Chabre, Marc, 17026

Chamberlin, Margaret E.,

17341

17341

17010

17528

Chamovitz, Daniel, 17348

Chan, Lawrence, Chan, Chi Kin, 17131

Chandler, Paulette, 17173 Chang, Wen-]., 17613 Chen, Chiareiy L., 17103

Choay, Jean, 17588 Cheng, Yi-Shan, 17286

Chou, Janice Yang, 17528 Chou, Kuo-Chen, 16938 Clark, David C., 17504 Co, Deborah, 17650 Cohen, Sara, 17083 Collins, Christine A,, 17240 Comstock, Kenine E., 16958 Conaway, Joan Weliky,

Conaway, Ronald C., 17300 Cook, Robert M., 17010 Coon, Minor J., 17253 Copeland, Terry D., 17309 Cote, Rick H., 17190 Crews, Brenda C., 17588 Cubitt, Andrew B., 17431 Dahl, Neera K., 16979 Dane, Keld, 17539 David, Fraeric, 17247 David, Peer, 16929 Davis, Michael G., 17397 de Brum-Fernandes, Artur J.,

de Kruijff, Ben, 17069 de Lanerolle, Primal, 16883 Deuel, Thomas F., 17334 Dhmawardhane,

Suranganie, 17431 Dharmesh, Shylaja M., 17096 Ding, Jiabing, 17326

Dix, Thomas A,, 17057 Ding, Xinxin, 17253

Dom, Gerald W., 11, 17397 Dixon, Brian, 16993

Downey, Gregory P., 17131 Dumont, Serge, 17547 Ehara, Gaku, 17205 Engler, Jeffrey A., 17341

Etlinger, Joseph D., 17413 Enyedi, Agnes, 17120

Fan, Bingqi, 17588 Fader, Stephan, 17418 Fass, Deborah, 17074 Feil, Sabine, 17362 Fenton, John W., 11,16899 Ferro-Luzzi Ames, Giovanna,

Fialkow, Lea, 17131 Fine, Richard E., 17427 Firtel, Richard A., 17431

17647

17300

17457

17648

AUTHOR INDEX

Fishman, Peter H., 17038

Fournel, Marielle, 17547 Flashner, Yehuda, 17083

Fritig, Bernard, 16987 French, Frank S., 17519

Fruchart, Jean-Charles,

Fsihi, Hafida, 17495 Fukita, Yosho, 17463

Fiirstenberger, Gerhard, Fiilop, Csaba, 17377

Gahmberg, Carl G., 17513

Gaudriault, Georges, 17138 Galloway-Salvo, Jill, 17051

Gehel, Thomas, 17623 Geltosky, John E., 17270

Gettins, Peter, 17588 Geoffroy, Pierrette, 16987

Glant, Tibor T., 17377 Gibson, Quentin H., 16993

Glimcher, Laurie H., 17074 Godowski, Paul J., 17145

Gong, Da-Wei, 17554 Gokcen, Sabiha, 17648

Gorgas, Gayle, 16883 Gotto, Antonio M., Jr.,

Grant, David F., 17628 Grenett, Hernan, 17341 Griffith, Jack, 17571 Grinstein, Sergio, 17131 Groffen, John, 16903 Grossman, Lawrence, 16871 Gu, Li Juan, 17334 Guedin, Denis, 17114 Guo, Chan, 17334

Gutheil, William G., 16979 Gurevich, Vsevolod V., 16879

Guy, Graeme R., 16949 Haasemann, Martina, 17277 Hajjar, David P., 17489 Hall, Anne V., 17478 Hammock, Bruce D., 17628 Hauri, Hans-Peter, 17640 Hawkins, Phillip T., 17162 Hayashi, Izumi, 17219 Heidecker, Gisela, 17309 Heisterkamp, Nora, 16903

Hemer, Frank, 17108 Heitz, Thierry, 16987

Henner, W. David, 16958 Heng, Henry H. Q., 17478

Hikita, Chinami, 17069 Hersh, Louis B., 17647

Hirschberg, Joseph, 17348 Hines, Ronald N., 17384

Honjo, Tasuku, 17463 Horikoshi, Masami, 17554

16966

17362

17647

Hosey, M. Marlene, 16879 Hoshiko, Shigeru, 17219 H@yer-Hansen, Gunilla,

Huuskonen, Jarkko, 17513

Inagami, Tadashi, 17045 Inesi, Giuseppe, 17018 Ingham, Kenneth C., 17211 Inui, Hiroshi, 17045 Ismail-Beigi, Faramarz,

Iwashima, Akio, 17440

Jackson, Craig M., 16899 Jackson, Trevor, 17162 Jalkanen, Markku, 17261 Jayaram, Makkuni, 17564 Jensen, Ole N., 17103 Johnson, Gary D., 17647 Johnson, Kara J., 16958 Jones, Larry R., 17018

Kaartinen, Vesa, 16903 Kaneko, Yoshinobu, 17440 Kang, Chul-Hee, 17648 Kantor, Carmela, 17513 Karlish, Steven J. D., 16929

Keddie, James S., 17504 Katada, Toshiaki, 16895

Kilgore, Michael, 17317 Kim, Chong M., 16879

Kim, Sung-Hou, 17648 Kim, Jin-Soo, 17392

Kjalke, Marianne, 17539 Kitami, Yutaka, 17045

Knehr, Michael, 17623 Kleinfeld, Alan M., 17578

Knolle, Jochen, 17277 Kokubo, Tetsuro, 17554 Komatsu, Hideyuki, 16974 Kondo, Takao, 17045 Kontani, Kenji, 16895 Korner, Christian, 17108 Kosik, Kenneth S., 17427 Kottwitz, Bmnhilde, 17495 Kriimer, Angela, 17640 Krieg, Peter, 17362 Kronman, Chanoch, 17083 Kupfer, Stuart R., 17519 Kusters, Ron, 17069

Langedijk, Johannes P. M.,

Langert, Wilhelm, 16907 Languino, Lucia R., 17270 Lee, Jehee, 17564 Legrand, Michel, 16987 Lei, Ke-Jian, 17528 Lei, K. Y., 17647 Leitner, Moshe, 17083 Lerea, Kenneth M., 17413

17539

17225

16875

Li, Ming, 17504

Li, Xiangquan, 16883 Li, Rui, 17513

Liou, Hsiou-Chi, 17074 Lin, Xin-Hua, 17334

Liu, Ji-Lan, 17528 Liscum, Laura, 16979

Liu, Siming, 17030 Loeb, John N., 17225 Lokker, Nathalie A,, 17145 Ludemann, Robert, 17413 Lutz, Hans U., 17418 Maccecchini, Maria-Luisa,

Mahendran, Ratha, 16949 Maidhof, Armin, 17277 Makabe, Osamu, 17219

Marcel, Yves L., 16966 Mancini, Francesco P., 17489

Marinos, Catherine, 16891 Marguet, Didier, 17247

Marschke, Keith B., 17519 Marsden, Philip A,, 17478

Matthews, Kathleen S., Martin, Nancy C., 17634

Mazar, Andrew, 17211 Mazella, Jean, 17138 Medved, Leonid V., 17211 Meloen, Rob H., 16875 Meng, Qiang-Hua, 16966 Miller, York E., 17010 Minna, John D., 17010 Mizushima, Shoji, 17069 Mizuta, Tatsunobu-Ryushin,

Mellegaard, Niels Erik, 17471

Morikami, Atsushi, 17205 Moreau, Eric, 17114

Morin, Peter J., 17427 Morris, Sheila L., 17063 Morrison, Deborah K., 17309 Mueller, Karl, 16907 Muller, Berndt, 17179, 17185 Muller, Eliane, 17457

Murphy, Denis J., 17504 Muller-Esterl, Werner, 17277

Nakamura, Kenzo, 17205 Nakatani, Yoshihiro, 17554

Ni, Feng, 16899 Nashed, Nashaat T., 17173

Nicholson, Andrew C., 17489 Nichols, Jeffry C., 17602

Nikaido, Kishiko, 17648 Nielsen, Peter E., 17471

Nishimura, Hiroshi, 17440 Ning, Qing, 16899

Nishina, Hiroshi, 16895 Nortamo, Pekka, 17513

17173

17602,17613

17463