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Nitric Oxide Synthase 1.14.13.39 Cody A Scholtens CHE 442 10/21/14

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Page 1: Nitric Oxide Synthase 1.14.13.39 Cody A Scholtens CHE 442 10/21/14

Nitric Oxide Synthase1.14.13.39

Cody A ScholtensCHE 44210/21/14

Page 2: Nitric Oxide Synthase 1.14.13.39 Cody A Scholtens CHE 442 10/21/14

BackgroundL-Arginine + NADPH +H+ Citrulline +NO+ NADP+

Neuronal NOS (1TLL)

Endothelial NOS(2NES)

Inducible NOS(1NOD)

Page 3: Nitric Oxide Synthase 1.14.13.39 Cody A Scholtens CHE 442 10/21/14

Crystal Structure

Page 4: Nitric Oxide Synthase 1.14.13.39 Cody A Scholtens CHE 442 10/21/14

NOS (oxidation)

Page 5: Nitric Oxide Synthase 1.14.13.39 Cody A Scholtens CHE 442 10/21/14

NOS (reduction)

Page 6: Nitric Oxide Synthase 1.14.13.39 Cody A Scholtens CHE 442 10/21/14
Page 7: Nitric Oxide Synthase 1.14.13.39 Cody A Scholtens CHE 442 10/21/14
Page 8: Nitric Oxide Synthase 1.14.13.39 Cody A Scholtens CHE 442 10/21/14
Page 9: Nitric Oxide Synthase 1.14.13.39 Cody A Scholtens CHE 442 10/21/14

Resources:

1.http://i1-news.softpedia-static.com/images/news2/Molecular-DNA-Switch-Found-to-Be-the-Same-for-All-Life-2.gif

2.http://www.rcsb.org/pdb/explore/explore.do?structureId=1TLL3.http://www.rcsb.org/pdb/explore/explore.do?structureId=2NSE4.http://www.jbc.org/content/279/36/37918.long 5.http://www.brenda-enzymes.org/enzyme.php?ecno=1.14.13.39

http://www.rcsb.org/pdb/explore/explore.do?structureId=2NSE
http://www.rcsb.org/pdb/explore/explore.do?structureId=2NSE

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